What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

2'-O-Propargyl A(Bz)-3'-phosphoramidite

Description: 2'-O-Propargyl A(Bz)-3'-phosphoramidite, a highly versatile compound, plays a pivotal role in the biomedical sector for crafting customized oligonucleotides. Its exceptional propargyl and benzoyl functionalities facilitate seamless bonding with a wide range of biomolecules. Hailed for its profound impact in drug discovery, this product aids in the creation of nucleic acid-driven therapeutics, notably those combating diverse ailments such as cancer, viral infections, and neurodegenerative disorders. Its paramount significance in the field underscores the significance of this remarkable compound.

CAT: BRP-00320

CAS: 171486-59-2

Molecular Formula: C50H54N7O8P

Molecular Weight: 911.98

Purity: ≥95%

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20 °C

InChIKey: ZNKFQCJEZKZIPC-XOMUZYEBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC#C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C50H54N7O8P/c1-8-29-61-45-44(65-66(63-30-15-28-51)57(34(2)3)35(4)5)42(64-49(45)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-16-11-9-12-17-36)31-62-50(37-18-13-10-14-19-37,38-20-24-40(59-6)25-21-38)39-22-26-41(60-7)27-23-39/h1,9-14,16-27,32-35,42,44-45,49H,15,29-31H2,2-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,66?/m1/s1

Synonyms: N4-Bz-5'-O-DMTr-2'-O-propargyladenosine-3'-CED-phosphoramidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyladenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; N6-Benzoyl-5'-O-DMT-2'-O-propynyladenosine 3'-CE phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-yl-adenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N-Benzoyl-2'-O-(2-propynyl)-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-5'-O-[phenylbis(4-methoxyphenyl)methyl]adenosine; DMTr-2'-O-propargyl-rA(Bz)-3'-CE-Phosphoramidite; 2'-O-propargyl Adenosine (n-bz) CED phosphoramidite; N6-Bz-DMT-2'-O-propargyl-A-CE-Phosphoramidite; [N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

VIC phosphoramidite, 6-isomer

Description: VIC is an asymmetrical xanthene dye used for the design of qPCR probes. VIC phosphoramidite, 6-isomer allows to introduce the label onto 5'-terminus of the oligonucleotide.

CAT: BRP-00472

CAS: 1414265-81-8

Molecular Formula: C52H59Cl3N3O10P

Molecular Weight: 1023.37

Purity: ≥95%

Appearance: White to Off-white Solid

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Storage: Store at -20 °C

Boiling Point: 940.7±65.0 °C (Predicted)

InChIKey: WNXGKJMDPRPEFO-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC(=C2C(=C1Cl)C3(C4=CC(=C(C=C4OC5=C3C=C(C(=C5)OC(=O)C(C)(C)C)C6=CC=CC=C6)OC(=O)C(C)(C)C)Cl)OC2=O)Cl)OCCC#N

IUPAC Name: [4,7,7'-trichloro-6-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxo-2'-phenylspiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate

InChI: InChI=1S/C52H59Cl3N3O10P/c1-30(2)58(31(3)4)69(64-24-18-21-56)63-23-17-12-11-16-22-57-46(59)34-26-38(54)43-44(45(34)55)52(68-47(43)60)35-25-33(32-19-14-13-15-20-32)39(66-48(61)50(5,6)7)28-40(35)65-41-29-42(37(53)27-36(41)52)67-49(62)51(8,9)10/h13-15,19-20,25-31H,11-12,16-18,22-24H2,1-10H3,(H,57,59)

Synonyms: 6-VIC Phosphoramidite

CAL Fluor Red 610 CE Phosphoramidite

Description: CAL Fluor Red 610 CE Phosphoramidite, a highly sensitive and reliable fluorescent dye, is commonly applied for the real-time PCR detection and quantification of nucleic acid targets relevant to the diagnosis and management of various diseases, including cancer and viral infections, rendering it an indispensable asset to the biomedical research community and clinical diagnostic industry.

CAT: BRP-00474

CAS: 861143-34-2

Molecular Formula: C46H57N5O4P2F6P

Molecular Weight: 919.93

Purity: 95%

Appearance: Red Solid

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Storage: Store at -20°C

InChIKey: AREDCQVONVVIKP-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CCN(CC1)C(=O)C2=CC=CC=C2C3=C4C=C5CCC[N+]6=C5C(=C4OC7=C3C=C8CCCN9C8=C7CCC9)CCC6.F[P-](F)(F)(F)(F)F

IUPAC Name: 3-[[di(propan-2-yl)amino]-[1-[2-(3-oxa-23-aza-9-azoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-16-yl)benzoyl]piperidin-4-yl]oxyphosphanyl]oxypropanenitrile;hexafluorophosphate

InChI: InChI=1S/C46H57N5O4P.F6P/c1-30(2)51(31(3)4)56(53-27-11-20-47)55-34-18-25-50(26-19-34)46(52)36-15-6-5-14-35(36)41-39-28-32-12-7-21-48-23-9-16-37(42(32)48)44(39)54-45-38-17-10-24-49-22-8-13-33(43(38)49)29-40(41)45;1-7(2,3,4,5)6/h5-6,14-15,28-31,34H,7-13,16-19,21-27H2,1-4H3;/q+1;-1

Synonyms: 1H,5H,11H,15H-Xantheno[2,3,4-ij:5,6,7-i'j']diquinolizin-18-ium, 9-[2-[[4-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]-1-piperidinyl]carbonyl]phenyl]-2,3,6,7,12,13,16,17-octahydro-, hexafluorophosphate(1-) (1:1); CAL Fluor Red 610 Amidite; CAL Fluor Red 610; CFR 610 Amidite

Spermine Phosphoramidite

Description: Spermine Phosphoramidite, a crucial component in synthesizing spermine-modified oligonucleotides, serves as a prime candidate for delving into DNA-protein interactions and cancer cell targeting, rendering itself a shining star in biomedical research. Uncovering new therapeutic avenues for neurodegenerative diseases and cancer is the cherry on top of this innovative product.

CAT: BRP-00485

CAS: 1969276-82-1

Molecular Formula: C56H73F12N6O9P

Molecular Weight: 1233.17

Purity: 95%

Appearance: Colourless oily matter

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1 g	$999	In stock

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Storage: Store at -20°C

InChIKey: LKEZZLVCFMFJGQ-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCN(CCCN(CCCCN(CCCN(CCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)C(=O)C(F)(F)F)C(=O)C(F)(F)F)C(=O)C(F)(F)F)C(=O)C(F)(F)F)OCCC#N

IUPAC Name: N-[3-[4-[bis(4-methoxyphenyl)-phenylmethoxy]butyl-(2,2,2-trifluoroacetyl)amino]propyl]-N-[4-[3-[4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxybutyl-(2,2,2-trifluoroacetyl)amino]propyl-(2,2,2-trifluoroacetyl)amino]butyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C56H73F12N6O9P/c1-41(2)74(42(3)4)84(83-40-16-29-69)82-39-15-13-33-73(51(78)56(66,67)68)37-18-35-71(49(76)54(60,61)62)31-11-10-30-70(48(75)53(57,58)59)34-17-36-72(50(77)55(63,64)65)32-12-14-38-81-52(43-19-8-7-9-20-43,44-21-25-46(79-5)26-22-44)45-23-27-47(80-6)28-24-45/h7-9,19-28,41-42H,10-18,30-40H2,1-6H3

Synonyms: N-[4-(4,4'-Dimethoxytrityloxy)butyl]-N,N4,N9,N-tetrakis(trifluoroacetyl)-spermine-N-butyl-4-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

5'-Hexynyl CE Phosphoramidite

Description: 5'-Hexynyl CE Phosphoramidite, an essential reagent in biomedical research for oligonucleotide synthesis, offers versatility in sequencing modification through its alkyne functionality, enabling conjugation with diverse biomolecules. The reagent presents vast potential in critical fields such as gene therapy, drug discovery, and disease diagnosis and management. Its unique characteristics position it as a promising asset in achieving complex nucleotide sequencing, furthering our understanding of genetic health and disease.

CAT: BRP-00510

CAS: 1048985-37-0

Molecular Formula: C15H27N2O2P

Molecular Weight: 298.37

Purity: 95%

Appearance: Colorless Oil

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100 mg	$299	In stock
1 g	$499	In stock

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Storage: Store at -20°C

Boiling Point: 339.7±27.0 °C (Predicted)

InChIKey: IFNKHZIJWLUIHZ-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCC#C)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-hex-5-ynoxyphosphanyl]oxypropanenitrile

InChI: InChI=1S/C15H27N2O2P/c1-6-7-8-9-12-18-20(19-13-10-11-16)17(14(2)3)15(4)5/h1,14-15H,7-10,12-13H2,2-5H3

Synonyms: 2-Cyanoethyl hex-5-yn-1-yl diisopropylphosphoramidite; 5-Hexyn-1-yl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

2'-O-C16-rA(Bz)-Phosphoramidite

Description: 2'-O-C16-rA(Bz)-Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a 2'-O-C16-rA(Bz) modification, where a C16 alkyl chain is attached to the 2'-position of riboadenosine (rA) and a benzoyl (Bz) group is attached to the adenine base. This modification enhances stability and functionality. It facilitates the production of modified RNA oligonucleotides with improved properties, suitable for various molecular biology and biotechnology applications, including RNA interference and gene expression studies.

CAT: BRP-00512

CAS: 2382942-35-8

Molecular Formula: C63H84N7O8P

Molecular Weight: 1098.38

Purity: ≥95%

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1 g	$599	In stock

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Storage: Store at -20 °C

InChIKey: JEFOGZDZKKCGEJ-OSIIFERKSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCOC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-hexadecoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C63H84N7O8P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-27-42-74-58-57(78-79(76-43-28-41-64)70(47(2)3)48(4)5)55(77-62(58)69-46-67-56-59(65-45-66-60(56)69)68-61(71)49-29-23-21-24-30-49)44-75-63(50-31-25-22-26-32-50,51-33-37-53(72-6)38-34-51)52-35-39-54(73-7)40-36-52/h21-26,29-40,45-48,55,57-58,62H,8-20,27-28,42-44H2,1-7H3,(H,65,66,68,71)/t55-,57-,58-,62-,79?/m1/s1

Synonyms: N6-Bz-5'-O-DMTr-2'-O-hexadecanyl adenosine 3'-CED phosphoramidite; DMTr-2'-O-C16-rA(Bz)-3'-CE-Phosphoramidite; 2'-O-C16-A(Bz) phosphoramidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

8-Azanebularine CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-8-azanebularine-3'-CE-Phosphoramidite is a chemical compound used in oligonucleotide synthesis. It protects the 5'-hydroxyl group with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it incorporates 8-azanebularine as a modified nucleoside. The 3'-CE phosphoramidite facilitates nucleotide addition during synthesis. This compound allows for the controlled synthesis of oligonucleotides with specific modifications, important for various applications in molecular biology and biotechnology.

CAT: BRP-00557

CAS: 771494-03-2

Molecular Formula: C45H60N7O7PSi

Molecular Weight: 870.08

Purity: ≥95%

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50 mg	$699	In stock
250 mg	$2399	In stock

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Storage: Store at -20 °C

Boiling Point: 827.8±65.0 °C (Predicted)

InChIKey: QEYQVSAEEYPGQB-IEXCOMMKSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](N2C3=NC=NC=C3N=N2)O[C@@H]1COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6

IUPAC Name: (2R,3R,4R,5R)-5-(3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H60N7O7PSi/c1-31(2)52(32(3)4)60(56-27-15-26-46)58-40-39(57-43(41(40)59-61(10,11)44(5,6)7)51-42-38(49-50-51)28-47-30-48-42)29-55-45(33-16-13-12-14-17-33,34-18-22-36(53-8)23-19-34)35-20-24-37(54-9)25-21-35/h12-14,16-25,28,30-32,39-41,43H,15,27,29H2,1-11H3/t39-,40-,41-,43-,60?/m1/s1

Synonyms: DMTr-2'-O-TBDMS-8-azanebularine-3'-CE-Phosphoramidite

5'-POM-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite is used in oligonucleotide synthesis. It is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-00571

CAS: 2419895-65-9

Molecular Formula: C40H57N7O12P2

Molecular Weight: 889.88

Purity: ≥98%

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Storage: Store at -20 °C

InChIKey: DCUPCJOKPAHCLB-OZKJWBRJSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OC)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C

IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C40H57N7O12P2/c1-26(2)47(27(3)4)60(55-20-15-19-41)59-31-29(18-21-61(51,56-24-53-37(49)39(5,6)7)57-25-54-38(50)40(8,9)10)58-36(32(31)52-11)46-23-44-30-33(42-22-43-34(30)46)45-35(48)28-16-13-12-14-17-28/h12-14,16-18,21-23,26-27,29,31-32,36H,15,20,24-25H2,1-11H3,(H,42,43,45,48)/b21-18+/t29-,31-,32-,36-,60?/m1/s1

Synonyms: N-[9-[(5E)-6-[Bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5,6-dideoxy-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-9H-purin-6-yl]benzamide; (E)-VP-2'-OMe-A(Bz)-CE-Phosphoramidite; (E)-Vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite; 5'-VP-2'-0Me-A(Bz)-CE-Phosphoramidite; (E)-5'-VP-2'-0Me-A(Bz)-CE-Phosphoramidite

Boc-PNA-C(Z)-OH

Description: Boc-PNA-C(Z)-OH is a cytosine-containing PNA monomer protected with Boc and benzyloxycarbonyl groups. The protection scheme stabilizes the nucleobase during chemical coupling steps. This design enables accurate incorporation of cytosine analogs into PNA sequences. It is utilized in constructing PNA strands for sequence-specific hybridization studies.

CAT: BRP-01182

CAS: 144564-94-3

Molecular Formula: C23H29N5O8

Molecular Weight: 503.51

Purity: 95%

Appearance: White to Off-white Powder

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1 g	$599	In stock

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Storage: -20°C for long term storage

Density: 1.32±0.1 g/cm3

Melting Point: 156 °C (dec.)

InChIKey: UCPRPVFFEVZHEJ-UHFFFAOYSA-N

CanonicalSMILES: CC(C)(C)OC(=O)NCCN(CC(=O)O)C(=O)CN1C=CC(=NC1=O)NC(=O)OCC2=CC=CC=C2

IUPAC Name: 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl-[2-[2-oxo-4-(phenylmethoxycarbonylamino)pyrimidin-1-yl]acetyl]amino]acetic acid

InChI: InChI=1S/C23H29N5O8/c1-23(2,3)36-21(33)24-10-12-27(14-19(30)31)18(29)13-28-11-9-17(25-20(28)32)26-22(34)35-15-16-7-5-4-6-8-16/h4-9,11H,10,12-15H2,1-3H3,(H,24,33)(H,30,31)(H,25,26,32,34)

Synonyms: Boc-C(Z)-Aeg-OH; N-(2-(4-(((Benzyloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetyl)-N-(2-((tert-butoxycarbonyl)amino)ethyl)glycine

5'-O-DMTr-2'-OMeU-methylphosphonamidite

Description: 5'-O-DMTr-2'-OMeU-methylphosphonamidite is an indispensable recompound widely employed in the field of compound, exhibiting immense significance in the research and development of altered oligonucleotides meticulously crafted for gene therapy and medicinal chemistry. Moreover, it assumes a pivotal role in the research and development of antisense oligonucleotides explicitly engineered to combat genetic disorders, infectious ailments and select malignancies.

CAT: BRP-01610

CAS: 191786-64-8

Molecular Formula: C38H48N3O8P

Molecular Weight: 705.78

Purity: ≥95%

Appearance: Off-white solid

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10 mg	$499	In stock

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Storage: Store at -20 °C

InChIKey: OMQYBRGCCIXKCN-IFQFNZHASA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(C)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-methylphosphanyl]oxy-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C38H48N3O8P/c1-25(2)41(26(3)4)50(8)49-34-32(48-36(35(34)46-7)40-23-22-33(42)39-37(40)43)24-47-38(27-12-10-9-11-13-27,28-14-18-30(44-5)19-15-28)29-16-20-31(45-6)21-17-29/h9-23,25-26,32,34-36H,24H2,1-8H3,(H,39,42,43)/t32-,34-,35-,36-,50?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite; 2'-OMe U Me-amidite; 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5'-O-DMTr-2'-OMe-U-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-OMe-uridine-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Uridine p-methyl phosphonamidite

5'-O-DMT-2'-O-TBDMS-2-Thiouridine 3'-CE phosphoramidite

Description: 5'-O-DMT-2'-O-TBDMS-2-Thiouridine 3'-CE phosphoramidite is a phosphoramidite derivative used for the solid-phase research and development of modified RNA sequences. With its 5'-O-DMT protection, 2'-O-TBDMS modification and 2-thiouridine incorporation, it enables the controlled research and development of RNA molecules for studying RNA-protein interactions and RNA-based therapeutics targeting diseases like cancer and viral infections.

CAT: BRP-01626

CAS: 163496-21-7

Molecular Formula: C45H61N4O8PSSi

Molecular Weight: 877.11

Purity: >95%

Appearance: Off-white solid

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1 g	$7980	In stock

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Storage: Store at -20 °C

InChIKey: BLKYMIQDVIRXHA-OHKMQFRXSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=S)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H61N4O8PSSi/c1-31(2)49(32(3)4)58(54-29-15-27-46)56-40-38(55-42(48-28-26-39(50)47-43(48)59)41(40)57-60(10,11)44(5,6)7)30-53-45(33-16-13-12-14-17-33,34-18-22-36(51-8)23-19-34)35-20-24-37(52-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,59)/t38-,40-,41-,42-,58?/m1/s1

Synonyms: 2'-OTBS 2-Thio-U amidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-2-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5-Aminoallyl-dU CEP

Description: 5-Aminoallyl-dU CEP is an essential component in the biomedical sector, extensively utilized for the research and development of modified nucleoside analogs, thus possessing distinctive utilities in the realm of medical investigation. Its significance prevails in the development of therapeutics intended to combat a myriad of ailments encompassing cancer, viral infections and neurodegenerative disorders.

CAT: BRP-01748

CAS: 144253-90-7

Molecular Formula: C44H51F3N5O9P

Molecular Weight: 881.87

Purity: ≥98% by HPLC

Appearance: White to Off-white powder

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Storage: Store at -20 °C

InChIKey: WBARYSWSAVXEHP-OOJPWNKJSA-N

CanonicalSMILES: N#CCCOP(OC1CC(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=C(C=CCNC(=O)C(F)(F)F)C(=O)NC5=O)N(C(C)C)C(C)C

IUPAC Name: N-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C44H51F3N5O9P/c1-29(2)52(30(3)4)62(59-25-11-23-48)61-37-26-39(51-27-31(40(53)50-42(51)55)12-10-24-49-41(54)44(45,46)47)60-38(37)28-58-43(32-13-8-7-9-14-32,33-15-19-35(56-5)20-16-33)34-17-21-36(57-6)22-18-34/h7-10,12-22,27,29-30,37-39H,11,24-26,28H2,1-6H3,(H,49,54)(H,50,53,55)/t37-,38+,39+,62?/m0/s1

Synonyms: 5-TFA-aminoallyl-dU Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propen-1-yl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propenyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

5'-O-DMT-5-Fluoro-2'-deoxyuridine-3'-CE Phosphoramidite

Description: 5'-O-DMT-5-Fluoro-2'-deoxyuridine-3'-CE Phosphoramidite is a highly potent reagent for the synthesis of 5-fluorouracil (5-FU) containing oligonucleotides, with potential applications in the treatment of cancer. By boosting the selectivity and efficacy of 5-FU, a well-established chemotherapy drug for different forms of cancer, this compound constitutes a promising avenue to enhance the therapeutic options available to patients.

CAT: BRP-01749

CAS: 142246-63-7

Molecular Formula: C39H46FN4O8P

Molecular Weight: 748.78

Purity: ≥98% by HPLC

Appearance: White to Off-white powder

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Storage: Store at -20°C

InChIKey: QXDBDJDCIBKCKF-QMTPQUJBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=C(C(=O)NC5=O)F

IUPAC Name: 3-[[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-22-10-21-41)52-34-23-36(43-24-33(40)37(45)42-38(43)46)51-35(34)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-20,24,26-27,34-36H,10,22-23,25H2,1-6H3,(H,42,45,46)/t34-,35+,36+,53?/m0/s1

Synonyms: 5-F-dU Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-fluoro-, 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-fluoro-uridine 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]; FdU-amidite; NSC-729744

GalNac-L96 free base

Description: GalNac-L96 free base is a galactosamine-conjugated ligand engineered to exploit the asialoglycoprotein receptor pathway, known for its strong affinity toward hepatocyte surfaces. Its structural framework contains an N-acetylgalactosamine moiety that promotes receptor-mediated recognition, offering precise targeting and high selectivity in lipid-based and nanoparticle systems. The free base form provides greater chemical flexibility for conjugation, surface modification, and lipid linkage, making it a versatile component in controlled molecular delivery and receptor–ligand interaction research. In formulation science, GalNac-L96 free base is applied to create functionalized liposomes with hepatocyte-specific uptake, advancing studies in carbohydrate-mediated recognition, molecular trafficking, and lipid functionalization for precision targeting applications.

CAT: BRP-01760

CAS: 1159408-61-3

Molecular Formula: C121H179N11O45

Molecular Weight: 2507.76

Purity: 98%

Appearance: Off-white to light yellow solid

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Storage: Store at -20 °C, sealed storage, away from moisture

Density: 1.31±0.1 g/cm3

Boiling Point: 1889.4±65.0 °C at 760 mmHg

InChIKey: XKEQVRGRWUKTIZ-OLTBZPFJSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC(=O)NC1C(C(C(OC1OCCCCC(=O)NCCCNC(=O)CCOCC(COCCC(=O)NCCCNC(=O)CCCCOC2C(C(C(C(O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)(COCCC(=O)NCCCNC(=O)CCCCOC3C(C(C(C(O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)NC(=O)CCCCCCCCCCC(=O)N4CC(CC4COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OC(=O)CCC(=O)O)COC(=O)C)OC(=O)C)OC(=O)C

IUPAC Name: 4-[(3R,5S)-1-[12-[[1,3-bis[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]propan-2-yl]amino]-12-oxododecanoyl]-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]pyrrolidin-3-yl]oxy-4-oxobutanoic acid

InChI: InChI=1S/C121H179N11O45/c1-76(133)128-108-114(171-85(10)142)111(168-82(7)139)95(70-164-79(4)136)175-117(108)161-61-29-26-37-98(145)122-55-32-58-125-101(148)52-64-158-73-120(74-159-65-53-102(149)126-59-33-56-123-99(146)38-27-30-62-162-118-109(129-77(2)134)115(172-86(11)143)112(169-83(8)140)96(176-118)71-165-80(5)137,75-160-66-54-103(150)127-60-34-57-124-100(147)39-28-31-63-163-119-110(130-78(3)135)116(173-87(12)144)113(170-84(9)141)97(177-119)72-166-81(6)138)131-104(151)40-24-19-17-15-16-18-20-25-41-105(152)132-68-94(174-107(155)51-50-106(153)154)67-91(132)69-167-121(88-35-22-21-23-36-88,89-42-46-92(156-13)47-43-89)90-44-48-93(157-14)49-45-90/h21-23,35-36,42-49,91,94-97,108-119H,15-20,24-34,37-41,50-75H2,1-14H3,(H,122,145)(H,123,146)(H,124,147)(H,125,148)(H,126,149)(H,127,150)(H,128,133)(H,129,134)(H,130,135)(H,131,151)(H,153,154)/t91-,94+,95+,96+,97+,108+,109+,110+,111-,112-,113-,114+,115+,116+,117+,118+,119+/m0/s1

Synonyms: L-96; Butanedioic acid, 1-[(3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] ester; 1-[(3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] butanedioate; GalNAc-L96-SA; L-96-Succinic Acid; GalNAc-L96-Succinate

Related CAS: 1159408-62-4 (TEA salt)

N6-Benzoyl-7'-hydroxy-N-trityl morpholino adenine

Description: N6-Benzoyl-7'-hydroxy-N-trityl morpholino adenine is a vital compound used for various applications, functioning as an inhibitor in biomedical studies related to diseases like cancer and inflammation.

CAT: BRP-01766

CAS: 956139-16-5

Molecular Formula: C36H32N6O3

Molecular Weight: 596.68

Purity: ≥95%

Appearance: White Solid

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Storage: Store at RT

Density: 1.3±0.1 g/cm3

Melting Point: 172-174°C

InChIKey: XFQQPEYYQOKYTE-IOWSJCHKSA-N

CanonicalSMILES: C1C(OC(CN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)N5C=NC6=C(N=CN=C65)NC(=O)C7=CC=CC=C7)CO

IUPAC Name: N-[9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C36H32N6O3/c43-23-30-21-41(36(27-15-7-2-8-16-27,28-17-9-3-10-18-28)29-19-11-4-12-20-29)22-31(45-30)42-25-39-32-33(37-24-38-34(32)42)40-35(44)26-13-5-1-6-14-26/h1-20,24-25,30-31,43H,21-23H2,(H,37,38,40,44)/t30-,31+/m0/s1

Synonyms: PMO-A Precusor; Morpholino-A(Bz); PMO Adesnosine Precusor; 6-Bz-7'-OH-N-trityl morpholino adenosine; N-[9-[(2R,6S)-6-(Hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-9H-purin-6-yl]benzamide

N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite

Description: N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite is an indispensable compound within the biomedical domain with widespread application as a phosphoramidite constituent during oligonucleotide synthesis, primarily in the research of antisense therapy and gene silencing.

CAT: BRP-01976

CAS: 142808-44-4

Molecular Formula: C46H50F2N5O8P

Molecular Weight: 869.89

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

InChIKey: XLVPZSDAOMSDQP-XBADOKRKSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1(F)F)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3,3-difluorooxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C46H50F2N5O8P/c1-31(2)53(32(3)4)62(59-29-13-27-49)61-41-39(60-43(46(41,47)48)52-28-26-40(51-44(52)55)50-42(54)33-14-9-7-10-15-33)30-58-45(34-16-11-8-12-17-34,35-18-22-37(56-5)23-19-35)36-20-24-38(57-6)25-21-36/h7-12,14-26,28,31-32,39,41,43H,13,29-30H2,1-6H3,(H,50,51,54,55)/t39-,41-,43-,62?/m1/s1

Synonyms: N4-Bz-DMT-2',2'-difluoro-dC-CE-Phosphoramidite; DMTr-2',2'-difluoro-dC(Bz)-3'-CED-phosphoramidite; Gemcitabine amidite; Gemcitabine 3'-CE phosporamidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine 3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine 3'-CE phosphoramidite; 5'-DMT-N4-Bz-2',2'-difluoro-dC 3'-CE phosphoramidite

5-Methyl-2'-Fluoro-U Phosphoramidite

Description: 5-Methyl-2'-Fluoro-U Phosphoramidite, a pivotal compound with paramount significance in the domain of biomedicine, assumes the role of a fundamental constituent within the intricate framework of synthesized nucleic acids. Its exceptional utility lies in its indispensable contribution to the progressive advancement of antisense oligonucleotide development. Notably, this phosphoramidite possesses an intrinsic capacity to effectively combat a myriad of ailments encompassing viral infections and genetic disorders, by selectively targeting specified genes or RNA sequences.

CAT: BRP-02020

CAS: 182700-06-7

Molecular Formula: C40H48FN4O8P

Molecular Weight: 762.82

Purity: 95%

Appearance: White to off-white powder

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5 g	$4980	In stock

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Storage: Store at -20 °C

InChIKey: XUCJAZSCNJHDKP-ANEPUODISA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H48FN4O8P/c1-26(2)45(27(3)4)54(51-23-11-22-42)53-36-34(52-38(35(36)41)44-24-28(5)37(46)43-39(44)47)25-50-40(29-12-9-8-10-13-29,30-14-18-32(48-6)19-15-30)31-16-20-33(49-7)21-17-31/h8-10,12-21,24,26-27,34-36,38H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35-,36-,38-,54?/m1/s1

Synonyms: 5-Me-5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite; 2'-F T amidite; 2'-Fluoro-dT Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methyluridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-Fluoro-5MeU-3'-phosphoramidite; DMTr-2'-F-dT-3'-CE-Phosphoramidite; DMT-5-Me-2'-F-dU-CE-Phosphoramidite

Fmoc-PNA-C(Bhoc)-OH

Description: Fmoc-PNA-C(Bhoc)-OH is a cytosine-based PNA monomer featuring Bhoc-protected nucleobase functionality and an Fmoc-protected backbone. The Bhoc group minimizes side reactions involving the cytosine exocyclic amine. This monomer supports efficient solid-phase synthesis of cytosine-containing PNA sequences. It is integrated into PNA constructs requiring controlled base chemistry.

CAT: BRP-02043

CAS: 186046-81-1

Molecular Formula: C39H35N5O8

Molecular Weight: 701.7

Purity: 98%

Appearance: White to Off-white Powder

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1 g	$319	In stock

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Storage: -20°C for long term storage

Density: 1.34±0.1 g/cm3

InChIKey: YPTOIRLDQISSCH-UHFFFAOYSA-N

CanonicalSMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)OC(=O)NC3=NC(=O)N(C=C3)CC(=O)N(CCNC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46)CC(=O)O

IUPAC Name: 2-[[2-[4-(benzhydryloxycarbonylamino)-2-oxopyrimidin-1-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

InChI: InChI=1S/C39H35N5O8/c45-34(23-44-21-19-33(41-37(44)48)42-39(50)52-36(26-11-3-1-4-12-26)27-13-5-2-6-14-27)43(24-35(46)47)22-20-40-38(49)51-25-32-30-17-9-7-15-28(30)29-16-8-10-18-31(29)32/h1-19,21,32,36H,20,22-25H2,(H,40,49)(H,46,47)(H,41,42,48,50)

Synonyms: 2-[[2-[4-[[(diphenylmethyl)oxy-oxomethyl]amino]-2-oxo-1-pyrimidinyl]-1-oxoethyl]-[2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]ethyl]amino]acetic acid; 2-[[2-[4-(benzhydryloxycarbonylamino)-2-oxopyrimidin-1-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

Fmoc-PNA-A(Bhoc)-OH

Description: Fmoc-PNA-A(Bhoc)-OH is an adenine-containing PNA monomer protected with Fmoc on the backbone and Bhoc on the nucleobase amine. The protection strategy preserves base integrity during synthetic cycles. It enables accurate introduction of adenine units into PNA oligomers. This monomer is commonly used in the preparation of sequence-specific PNA strands.

CAT: BRP-02044

CAS: 186046-82-2

Molecular Formula: C40H35N7O7

Molecular Weight: 725.7

Purity: 98%

Appearance: White to Off-white Powder

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Storage: -20°C for long term storage

Density: 1.39±0.1 g/cm3

Application:

Fmoc-PNA-A(Bhoc)-OH is an Fmoc PNA monomer containing an Fmoc (9-fluorenylmethoxycarbonyl) group for solid phase peptide synthesis and a Bhoc (benzhydryloxycarbonyl) protecting group for specific applications.

1. Solid Phase Peptide Synthesis (SPPS): The solid phase synthesis of PNA oligomers is one of the primary uses of Fmoc-PNA-A(Bhoc)-OH. Stepwise assembly of PNA sequences on a solid support is made possible by the potent approach known as SPPS, which usually makes use of Fmoc chemistry. PNA monomers can be controlled when introduced to the expanding chain while shielding reactive functional groups to avoid unwanted side reactions by using Fmoc-PNA-A(Bhoc)-OH as a building block. PNA oligomers may be synthesized efficiently with high yield and purity using this approach, which is crucial for researching PNA's interactions with other biomolecules and nucleic acids.

2. Antisense therapy: PNA oligomers have demonstrated significant promise as antisense agents for controlling gene expression, particularly those made with Fmoc-PNA-A(Bhoc)-OH. Complementary base pairing allows PNA oligomers to bind particular mRNA sequences, which in turn prevent translation and, eventually, the expression of genes. Using Fmoc-PNA-A(Bhoc)-OH to synthesize antisense PNA oligomers guarantees the stability and specificity of the targeted mRNA, making it a potentially effective molecular treatment for hereditary and other illnesses.

3. Diagnostic instruments: Fmoc-PNA-A(Bhoc)-OH can also be employed to create instruments for the detection of proteins and nucleic acids. PNA can identify target sequences in biological materials with strong binding affinity for complementary DNA/RNA sequences. Researchers can develop extremely sensitive and selective instruments to identify gene mutations, viral infections, and biomarkers linked to a variety of diseases by integrating Fmoc-PNA-A(Bhoc)-OH into probes or biosensors. This application has significant effects on tracking patient response to treatment and enhancing disease diagnosis.

4. Nanotechnology: PNA is a desirable option for nanotechnology applications due to its special qualities, which include stability and hybridization ability. Fmoc-PNA-A(Bhoc)-OH can be conjugated to nanoparticles or other nanostructures to create functional materials for gene editing, targeted drug administration, and imaging applications. The adaptability and programmability of PNA-based nanodevices are improved by the ability to accurately change PNA sequences through solid-phase synthesis techniques, creating new avenues for innovation in nanomedicine and biotechnology.

5. Pharmacogenomics: As personalized medicine continues to advance, PNA oligomers synthesized using Fmoc-PNA-A(Bhoc)-OH may play a key role in pharmacogenomics. By targeting specific genetic variants associated with drug metabolism or disease susceptibility, PNA-based therapies can be tailored to individual patients to improve efficacy and safety.

InChIKey: LVVQRXRVCLWIIO-UHFFFAOYSA-N

CanonicalSMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)OC(=O)NC3=NC=NC4=C3N=CN4CC(=O)N(CCNC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57)CC(=O)O

IUPAC Name: 2-[[2-[6-(benzhydryloxycarbonylamino)purin-9-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

InChI: InChI=1S/C40H35N7O7/c48-33(46(22-34(49)50)20-19-41-39(51)53-23-32-30-17-9-7-15-28(30)29-16-8-10-18-31(29)32)21-47-25-44-35-37(42-24-43-38(35)47)45-40(52)54-36(26-11-3-1-4-12-26)27-13-5-2-6-14-27/h1-18,24-25,32,36H,19-23H2,(H,41,51)(H,49,50)(H,42,43,45,52)

Synonyms: 2-[[2-[6-[[(diphenylmethyl)oxy-oxomethyl]amino]-9-purinyl]-1-oxoethyl]-[2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]ethyl]amino]acetic acid; 2-[[2-[6-(benzhydryloxycarbonylamino)purin-9-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

Fmoc-PNA-G(Bhoc)-OH

Description: Fmoc-PNA-G(Bhoc)-OH is a guanine-containing PNA monomer protected with Bhoc on the nucleobase and Fmoc on the backbone. The protection scheme ensures controlled reactivity of the guanine functional groups during assembly. It supports accurate synthesis of guanine-rich PNA sequences. This monomer is compatible with standard peptide-coupling-based PNA synthesis workflows.

CAT: BRP-02045

CAS: 186046-83-3

Molecular Formula: C40H35N7O8

Molecular Weight: 741.76

Purity: 98%

Appearance: White to Off-white Powder

Size	Price	Stock	Quantity
1 g	$319	In stock

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Storage: -20°C for long term storage

Density: 1.4±0.1 g/cm³

InChIKey: ZNHVLNAONKUINW-UHFFFAOYSA-N

CanonicalSMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)OC(=O)NC3=NC4=C(C(=O)N3)N=CN4CC(=O)N(CCNC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57)CC(=O)O

IUPAC Name: 2-[[2-[2-(benzhydryloxycarbonylamino)-6-oxo-1H-purin-9-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

InChI: InChI=1S/C40H35N7O8/c48-32(46(22-33(49)50)20-19-41-39(52)54-23-31-29-17-9-7-15-27(29)28-16-8-10-18-30(28)31)21-47-24-42-34-36(47)43-38(44-37(34)51)45-40(53)55-35(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-18,24,31,35H,19-23H2,(H,41,52)(H,49,50)(H2,43,44,45,51,53)

Synonyms: 2-[N-[2-(Fmoc-amino)ethyl]-2-[2-[[(benzhydryloxy)carbonyl]amino]-6-oxo-1H-purin-9(6H)-yl]acetamido]acetic Acid