Phosphoramidites

Description: Aquafluor 593 is a highly fluorescent molecule with maximum absorption at 593 nm and maximum emission at 613 nm, with a quantum yield of 0.6. The fluorescence of Aquafluor 593 is very little affected by pH, with only a few percent variation in the pH range of 5-8. Moreover, when heated from 20°C to 95°C, the fluorescence only decreased by about 30%.

CAT: BRP-00476

CAS: 2378004-16-9

Molecular Formula: C57H78F3N6O8P2+

Molecular Weight: 1094.23

Description: Quasar 670 Phosphoramidite is a specialized chemical used in oligonucleotide synthesis for molecular biology and biotechnology applications. It is a type of phosphoramidite reagent designed to incorporate the Quasar 670 fluorescent dye into synthetic oligonucleotides. This dye is part of the Quasar series of fluorescent dyes, known for their high brightness and photostability. Quasar 670 Phosphoramidite enables the synthesis of labeled oligonucleotides for various applications such as fluorescence in situ hybridization (FISH), real-time PCR, and nucleic acid detection assays. Its incorporation allows researchers to visualize and track nucleic acids in biological samples with high sensitivity and specificity.

CAT: BRP-00478

Molecular Formula: C48H69F6N5O3P2

Molecular Weight: 940.05

Description: DusQ 1 phosphoramidite is a true dark quencher with broad absorption curve which covers the visible spectrum with maximum in green to yellow region. It is used for the synthesis of dual labeled oligonucleotide probes for qPCR bearing 5'-quencher DusQ 1 and other FRET applications for multiplexing assays.

CAT: BRP-00479

CAS: 374591-94-3

Molecular Formula: C55H63N8O8P

Molecular Weight: 995.11

Purity: ≥95%

Appearance: Black Powder

Description: DusQ 2 is a dark quenched dye used in the synthesis of double-labeled oligonucleotide probes for qPCR with a 5' quench agent. This quencher is ideal for HEX, JOE, ROX, Cyanine5 and other dyes that have emission spectra in the orange and red parts of the spectrum.

CAT: BRP-00480

CAS: 374591-98-7

Molecular Formula: C54H61N8O9P

Molecular Weight: 997.09

Purity: NMR 1H, 31P, HPLC-MS (95%)

Appearance: Dark colored solid

Description: 5'-Amino-Modifier C3 PDA is a biomedical research reagent used for oligonucleotide and DNA modification. Its versatility is manifested in facilitating the linking of a variety of molecules, such as antibodies and fluorescent dyes, enabling diagnostic and therapeutic interventions.

CAT: BRP-00481

Molecular Formula: C21H33N4O4P

Molecular Weight: 436.49

Description: 5'-Amino-Modifier C6 PDA is a chemical reagent used in oligonucleotide synthesis for molecular biology and biotechnology applications. It is a modification reagent designed to introduce an amino group at the 5' end of synthetic oligonucleotides. This amino group enables further conjugation with various molecules, such as fluorescent dyes, biotin, or other chemical groups, allowing for labeling or functionalization of the oligonucleotides. The C6 designation refers to the presence of a carbon chain spacer (hexyl linker) between the amino group and the phosphate group of the oligonucleotide backbone. This modification is particularly useful for applications such as PCR, sequencing, hybridization assays, and probe-based detection methods.

CAT: BRP-00482

CAS: 1445745-26-5

Molecular Formula: C24H39N4O4P

Molecular Weight: 478.57

Appearance: Light-yellow oily matter

Description: Thiol-Modifier C3 S-S CE Phosphoramidite is a specialized reagent used in oligonucleotide synthesis for molecular biology applications. It introduces a thiol (-SH) group into synthetic oligonucleotides at the third carbon position (C3) from the 5' end, connected to a disulfide bridge for stability. This modification enables reversible conjugation reactions, facilitating various applications such as DNA-protein interactions, surface immobilization, and biosensor development.

CAT: BRP-00483

CAS: 1263065-01-5

Molecular Formula: C36H49N2O5PS2

Molecular Weight: 684.89

Purity: ≥95%

Appearance: Colourless oily matter

Description: Spacer phosphamides C3, C9, C12, and C18 are used to insert spacer arms in oligonucleotides, and these compounds can be added multiple times when longer spacer arms are needed.

CAT: BRP-00484

CAS: 158041-82-8

Molecular Formula: C36H49N2O5P

Molecular Weight: 620.77

Purity: ≥98%

Appearance: Colourless oily matter

Description: Spermine Phosphoramidite, a crucial component in synthesizing spermine-modified oligonucleotides, serves as a prime candidate for delving into DNA-protein interactions and cancer cell targeting, rendering itself a shining star in biomedical research. Uncovering new therapeutic avenues for neurodegenerative diseases and cancer is the cherry on top of this innovative product.

CAT: BRP-00485

CAS: 942054-48-0

Molecular Formula: C56H73F12N6O9P

Molecular Weight: 1233.17

Appearance: Colourless oily matter

Description: 5'-Ferrocene CE Phosphoramidite is an oligonucleotide synthesis reagent that adds the electromagnetic group ferrocene to the oligonucleotide chain for application in oligonucleotide labeling. The absorption wavelength of 5'-Ferrocene CE Phosphoramidite is 438 nm and the extinction coefficient is 230M-1 cm-1.

CAT: BRP-00486

Molecular Formula: C26H40FeN3O3P

Molecular Weight: 529.44

Purity: ≥95%

Appearance: Orange solid

Description: rG (iPr-Pac) CE-Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It incorporates a guanosine (G) residue modified with a tert-butyldimethylsilyl (TBDMS) group at the 2'-position and an isopropyl-phenoxyacetyl (iPr-Pac) group. The TBDMS group provides stability during chemical synthesis, while the iPr-Pac group enhances functionality. The CE designation indicates its compatibility with controlled-efficiency (CE) phosphoramidite chemistry, ensuring efficient incorporation during solid-phase synthesis. This reagent facilitates the production of modified RNA oligonucleotides with improved stability and functionality, suitable for various molecular biology and biotechnology applications, including RNA interference and gene expression studies.

CAT: BRP-00495

CAS: 689283-85-0

Molecular Formula: C57H74N7O10PSi

Molecular Weight: 1076.32

Description: Quasar 570 Amidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a fluorescent dye molecule that emits light at a wavelength of 570 nanometers, enabling the labeling of nucleic acid sequences during synthesis. This allows for the detection and visualization of the synthesized oligonucleotides in various molecular biology and biotechnology applications, including DNA sequencing, PCR, and fluorescence in situ hybridization (FISH). The Quasar 570 Amidite facilitates the development of labeled probes and primers for sensitive and specific nucleic acid detection assays.

CAT: BRP-00507

CAS: 1207162-64-8

Molecular Formula: C44H65F6N5O4P2

Molecular Weight: 903.95

Appearance: Red solid

Description: Long trebler phosphoramidite is a branching reagent for oligonucleotide synthesis allowing to synthesize branched DNA structures using a standard DNA synthesizer.After the condensation of the trebler, three DNA branches begin to grow simultaneously with each step of the synthesis. Deblock of this construct gives rise to DNA containing a branching point. One arm (stem) is attached to the branch point with its 5'-end, and other arms (branches) are attached with their 3'-ends. Reverse amidites can be used to prepare constructs with different branch orientations. Repetitive condensations of trebler results in formation of DNA dendrimers.

CAT: BRP-00509

CAS: 1516489-83-0

Molecular Formula: C89H107N2O15P

Molecular Weight: 1475.78

Purity: NMR 1H, 31P, HPLC-MS (95%)

Appearance: viscous yellowish oil

Description: 2'-O-C16-rA(Bz)-Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a 2'-O-C16-rA(Bz) modification, where a C16 alkyl chain is attached to the 2'-position of riboadenosine (rA) and a benzoyl (Bz) group is attached to the adenine base. This modification enhances stability and functionality. It facilitates the production of modified RNA oligonucleotides with improved properties, suitable for various molecular biology and biotechnology applications, including RNA interference and gene expression studies.

CAT: BRP-00512

CAS: 2382942-35-8

Molecular Formula: C63H84N7O8P

Molecular Weight: 1098.38

Purity: ≥95%

Description: 6-Bromohexyl Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a 6-bromohexyl group attached to the phosphoramidite backbone. This modification allows for the introduction of a bromohexyl moiety into the oligonucleotide sequence, facilitating further functionalization or conjugation reactions. This reagent enables the synthesis of modified oligonucleotides with specific chemical properties, suitable for various molecular biology and biotechnology applications, including DNA/RNA labeling, cross-linking, and affinity purification.

CAT: BRP-00513

CAS: 956093-29-1

Molecular Formula: C15H30BrN2O2P

Molecular Weight: 381.29

Purity: ≥95%

Description: 5'-DBCO-TEG Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a dibenzocyclooctyne (DBCO) functional group attached to a triethylene glycol (TEG) linker at the 5'-end of the oligonucleotide sequence. This modification enables bioconjugation through strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry reactions. It facilitates the conjugation of the oligonucleotide to azide-modified molecules or surfaces, allowing for various applications such as labeling, imaging, and bioconjugation studies.

CAT: BRP-00514

CAS: 1527468-08-1

Molecular Formula: C38H53N4O7P

Molecular Weight: 708.83

Purity: ≥95%

Description: Spacer C2 phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) group attached to an ethane-diol linker, which in turn is linked to a phosphoramidite backbone. This modification allows for the controlled addition of the oligonucleotide to the growing chain during solid-phase synthesis. The DMT group serves as a protecting group for the nucleotide base, preventing unwanted reactions during synthesis. The ethane-diol linker provides flexibility and accessibility to the nucleotide, facilitating efficient coupling reactions. This reagent enables the synthesis of high-quality oligonucleotides suitable for various molecular biology and biotechnology applications, including PCR, sequencing, and gene editing.

CAT: BRP-00515

CAS: 161029-24-9

Molecular Formula: C32H41N2O5P

Molecular Weight: 564.65

Purity: ≥95% by HPLC

Description: DDP-Amidite is a specialized reagent used in oligonucleotide synthesis. It features a 1,3-di-O-(4,4'-dimethoxytrityl)-glycerol modification attached to a controlled efficiency (CE) phosphoramidite backbone. This modification provides a coupling site for the addition of nucleotide units during solid-phase synthesis, enabling the controlled construction of oligonucleotide sequences. Overall, this reagent facilitates the efficient and precise synthesis of oligonucleotides with specific chemical properties, suitable for various molecular biology and biotechnology applications.

CAT: BRP-00516

CAS: 125922-95-4

Molecular Formula: C54H61N2O8P

Molecular Weight: 897.04

Purity: ≥95% by HPLC

Appearance: White, off-white to light yellow powder

Description: 5'-Trimethoxystilbene Cap Phosphoramidite is a reagent used in oligonucleotide synthesis, featuring a trimethoxystilbene cap group at the 5'-end. This modification enhances stability and offers versatility for various molecular biology applications, including nucleic acid detection and drug delivery.

CAT: BRP-00518

CAS: 1000852-27-6

Molecular Formula: C30H42N3O6P

Molecular Weight: 571.65

Description: 5'-Pyrene Cap Phosphoramidite is a reagent utilized in oligonucleotide synthesis. It contains a pyrene cap group at the 5'-end of the oligonucleotide sequence. This modification provides enhanced stability and fluorescence properties to the oligonucleotide. It is commonly used in applications such as fluorescence labeling, nucleic acid detection, and biomolecular interactions studies.

CAT: BRP-00519

CAS: 1131589-25-7

Molecular Formula: C30H36N3O2P

Molecular Weight: 501.60