Phosphoramidites

CN-LNA-G(iBu)-CE Phosphoramidite

Description: CN-LNA-G(iBu)-CE Phosphoramidite is a phosphoramidite building block designed for solid-phase oligonucleotide synthesis, incorporating a Locked Nucleic Acid (LNA) scaffold where the ribose ring is constrained by a 2'-O to 4'-C methylene bridge to enhance duplex stability and hybridization affinity. It contains guanine as the nucleobase, protected with an isobutyryl (iBu) group, along with a 5'-dimethoxytrityl (DMTr) protecting group and a 3'-cyanoethyl (CE) phosphoramidite moiety for controlled stepwise coupling. It inherits the high efficiency of the LNA series modifications while offering improved hydrophilicity and lower toxicity. This phosphoramidite is applied in the synthesis of modified oligonucleotides such as antisense molecules, siRNAs, and diagnostic probes, providing enhanced nuclease resistance, stronger binding to complementary sequences, and improved performance in therapeutic and molecular biology applications.

CAT: BRP-02699

Molecular Formula: C46H53N8O9P

Molecular Weight: 892.95

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InChIKey: HDFVVMUPRQZFAG-XBTUEPHFSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@]4(O5)[C@H]([C@H]([C@@H]5N6C(N=C(NC(C(C)C)=O)NC7=O)=C7N=C6)O[C@H]4C#N)OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C46H53N8O9P/c1-28(2)41(55)51-44-50-40-37(42(56)52-44)49-27-53(40)43-38-39(63-64(60-24-12-23-47)54(29(3)4)30(5)6)45(62-43,36(25-48)61-38)26-59-46(31-13-10-9-11-14-31,32-15-19-34(57-7)20-16-32)33-17-21-35(58-8)22-18-33/h9-11,13-22,27-30,36,38-39,43H,12,24,26H2,1-8H3,(H2,50,51,52,55,56)/t36-,38+,39-,43+,45-,64?/m0/s1

Synonyms: (1S,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-cyano-3-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-ODMT CN-LNA G(iBu) Phosphoramidite (Amidite); N2-ibu-G-(S)-cEt-Phosphoramidite; CN-LNA-G(iBu) phosphoramidite; CN-LNA-rG(ibu) Phosphoramidite; CN-LNA-G(iBu)-3'-CE-Phosphoramidite; CN-LNA-G(iBu) amidite

CN-LNA-5-MeU-CE Phosphoramidite

Description: CN-LNA-5-MeU-CE Phosphoramidite is a phosphoramidite building block used in solid-phase oligonucleotide synthesis, featuring a Locked Nucleic Acid (LNA) framework where the ribose ring is locked by a 2'-O to 4'-C methylene bridge to enhance duplex stability and binding affinity. Its nucleobase is 5-methyluridine (5-MeU), providing improved base stacking and additional thermal stability, while the 5'-hydroxyl is protected with a dimethoxytrityl (DMTr) group and the 3'-position is functionalized with a cyanoethyl (CE) phosphoramidite for stepwise incorporation. It inherits the high efficiency of LNA modifications while offering improved hydrophilicity and lower toxicity. This phosphoramidite is widely employed in the synthesis of modified oligonucleotides, including antisense strands, siRNAs, and molecular probes, to improve nuclease resistance, enhance hybridization strength, and increase overall therapeutic and diagnostic potential.

CAT: BRP-02700

CAS: 2404654-12-0

Molecular Formula: C42H48N5O9P

Molecular Weight: 797.83

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InChIKey: UTQCMGOOTHXIHS-BHXGXGLPSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@]4(O5)[C@H]([C@H]([C@@H]5N6C=C(C)C(NC6=O)=O)O[C@H]4C#N)OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C42H48N5O9P/c1-27(2)47(28(3)4)57(53-23-11-22-43)56-37-36-39(46-25-29(5)38(48)45-40(46)49)55-41(37,35(24-44)54-36)26-52-42(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-21,25,27-28,35-37,39H,11,23,26H2,1-7H3,(H,45,48,49)/t35-,36+,37-,39+,41-,57?/m0/s1

Synonyms: CN-LNA-T-CE Phosphoramidite; 5'-ODMT CN-LNA m5U Phosphoramidite (Amidite); CN-LNA-m5U phosphoramidite; CN-LNA-m5U-3'-CE-Phosphoramidite; CN-LNA-T phosphoramidite; CN-LNA-5-Me-U Phosphoramidite; CN-LNA-T-CE-Phosphoramidite; (1S,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-cyano-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-O-DMT-2'-O-POM-U-3'-CE-Phosphoramidite

Description: 5'-O-DMT-2'-O-POM-U-3'-CE Phosphoramidite is a chemically modified uridine building block used in solid-phase oligonucleotide synthesis, where the ribose carries a 2'-O-(pivaloyloxymethyl) (POM) protecting group that enhances stability and modulates oligonucleotide properties. The uracil nucleobase remains unprotected, the 5'-hydroxyl is protected with a dimethoxytrityl (DMT) group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for stepwise incorporation into oligonucleotide chains. This reagent is typically employed in the preparation of modified RNAs and therapeutic oligonucleotides, where the POM modification can influence nuclease resistance, pharmacokinetics, and biological performance while retaining efficient hybridization with complementary sequences.

CAT: BRP-02701

Molecular Formula: C45H57N4O11P

Molecular Weight: 860.94

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InChIKey: CWFIVBQKXNPXJJ-WXSPLRIASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCOC(=O)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: [(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxymethyl 2,2-dimethylpropanoate

InChI: InChI=1S/C45H57N4O11P/c1-30(2)49(31(3)4)61(58-27-13-25-46)60-39-37(59-41(48-26-24-38(50)47-43(48)52)40(39)55-29-56-42(51)44(5,6)7)28-57-45(32-14-11-10-12-15-32,33-16-20-35(53-8)21-17-33)34-18-22-36(54-9)23-19-34/h10-12,14-24,26,30-31,37,39-41H,13,27-29H2,1-9H3,(H,47,50,52)/t37-,39-,40-,41-,61?/m1/s1

Synonyms: (((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate; 5'-O-DMT-2'-O-(pivaloyloxymethyl)uridine 3'-CE phosphoramidite; 2'-O-POM-U-3'-phosphoramidite; 5'-O-DMTr-2'-O-(2-pivaloyloxymethyl)-uridine-3'-CED-phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-pivaloyloxymethyl)uridine 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-(2-pivaloyloxymethyl)uridine

5'-O-DMT-2'-O-POM-A(Bz)-3'-CE-Phosphoramidite

Description: 5'-O-DMT-2'-O-POM-A(Bz)-3'-CE Phosphoramidite is an adenosine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, incorporating a 2'-O-(pivaloyloxymethyl) (POM) modification on the ribose to enhance stability and optimize pharmacological properties. The adenine base is protected with a benzoyl (Bz) group, the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite, enabling stepwise chain elongation. This reagent is widely used in the synthesis of modified RNAs and therapeutic oligonucleotides, where the POM modification contributes to improved nuclease resistance, altered pharmacokinetics, and reliable hybridization performance with complementary sequences.

CAT: BRP-02702

Molecular Formula: C53H62N7O10P

Molecular Weight: 988.09

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InChIKey: MVMDULHZEUVEIS-AEBGNYAMSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H](OCOC(C(C)(C)C)=O)[C@H](N2C=NC3=C(NC(C4=CC=CC=C4)=O)N=CN=C23)O[C@@H]1COC(C5=CC=C(OC)C=C5)(C6=CC=C(OC)C=C6)C7=CC=CC=C7

IUPAC Name: (((2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl)oxy)methyl pivalate

InChI: InChI=1S/C53H62N7O10P/c1-35(2)60(36(3)4)71(68-30-16-29-54)70-45-43(31-67-53(38-19-14-11-15-20-38,39-21-25-41(63-8)26-22-39)40-23-27-42(64-9)28-24-40)69-50(46(45)65-34-66-51(62)52(5,6)7)59-33-57-44-47(55-32-56-48(44)59)58-49(61)37-17-12-10-13-18-37/h10-15,17-28,32-33,35-36,43,45-46,50H,16,30-31,34H2,1-9H3,(H,55,56,58,61)/t43-,45-,46-,50-,71?/m1/s1

Synonyms: N6-Benzoyl-5'-O-DMT-2'-O-((pivaloyloxymethyl))adenosine 3'-CE phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-((pivaloyloxymethyl))adenosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphorramidite; N6-Bz-5'-O-DMTr-2'-O-((pivaloyloxymethyl))-adenosine-3'-CED-phosphoramidite; 2'-O-POM-A(Bz)-3'-phosphoramidite; N6-Benzoyl-5'-O-DMT-2'-O-POM-adenosine 3'-CE phosphoramidite; DMT-2'-O-POM-A(Bz)-CE-Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(pivaloyloxymethyl)-adenosine-3'-cyanoethyl Phosphoramidite

5'-O-DMT-2'-O-POM-C(Ac)-3'-CE-Phosphoramidite

Description: 5'-O-DMT-2'-O-POM-C(Ac)-3'-CE Phosphoramidite is a cytidine-derived phosphoramidite building block designed for solid-phase oligonucleotide synthesis, featuring a 2'-O-(pivaloyloxymethyl) (POM) modification on the ribose that enhances chemical stability and modulates oligonucleotide properties. The cytosine base is protected with an acetyl (Ac) group to prevent undesired side reactions, while the 5'-hydroxyl is safeguarded by a dimethoxytrityl (DMT) group and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for efficient stepwise incorporation. This reagent is employed in the synthesis of modified RNAs and therapeutic oligonucleotides, where the POM modification provides improved nuclease resistance, influences pharmacokinetic behavior, and helps maintain effective hybridization with complementary strands.

CAT: BRP-02703

Molecular Formula: C47H60N5O11P

Molecular Weight: 901.99

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InChIKey: XGSYTNZPEKBGAM-JFALYFJISA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCOC(=O)C(C)(C)C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: [(2R,3R,4R,5R)-2-(4-acetamido-2-oxopyrimidin-1-yl)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-3-yl]oxymethyl 2,2-dimethylpropanoate

InChI: InChI=1S/C47H60N5O11P/c1-31(2)52(32(3)4)64(61-28-14-26-48)63-41-39(62-43(42(41)58-30-59-44(54)46(6,7)8)51-27-25-40(49-33(5)53)50-45(51)55)29-60-47(34-15-12-11-13-16-34,35-17-21-37(56-9)22-18-35)36-19-23-38(57-10)24-20-36/h11-13,15-25,27,31-32,39,41-43H,14,28-30H2,1-10H3,(H,49,50,53,55)/t39-,41-,42-,43-,64?/m1/s1

Synonyms: (((2R,3R,4R,5R)-2-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl)oxy)methyl pivalate; N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-(pivaloyloxymethyl)cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-(pivaloyloxymethyl)-N4-Acetyl-cytidine 3'-CE phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-O-(pivaloyloxymethyl)cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMTr-N4-Ac-2'-O-POM-cytidine-3'-CED Phosphoramidite; DMT-2'-O-POM-rC(Ac) Phosphoramidite; 2'-O-POM-Ac-rC-CE-Phosphoramidite; 5'-DMT-2'-O-POM-N4-Acetyl-Cytidine Phosphoramidite

5'-O-DMT-2'-O-POM-G(iBu)-3'-CE-Phosphoramidite

Description: 5'-O-DMT-2'-O-POM-G(iBu)-3'-CE Phosphoramidite is a guanosine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, featuring a 2'-O-(pivaloyloxymethyl) (POM) modification on the ribose that enhances stability and modulates pharmacological behavior. The guanine base is protected with an isobutyryl (iBu) group, the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) protecting group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for stepwise incorporation during automated synthesis. This reagent is employed in the preparation of modified RNAs and therapeutic oligonucleotides, where the POM substitution provides improved nuclease resistance, influences pharmacokinetic properties, and supports strong and selective hybridization with complementary strands.

CAT: BRP-02704

Molecular Formula: C50H64N7O11P

Molecular Weight: 970.07

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InChIKey: HLRNGXGLQFPUJA-NWGULGMGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H](OCOC(C(C)(C)C)=O)[C@H](N2C=NC3=C2N=C(NC(C(C)C)=O)NC3=O)O[C@@H]1COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

IUPAC Name: (((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate

InChI: InChI=1S/C50H64N7O11P/c1-31(2)44(58)54-48-53-43-40(45(59)55-48)52-29-56(43)46-42(63-30-64-47(60)49(7,8)9)41(68-69(66-27-15-26-51)57(32(3)4)33(5)6)39(67-46)28-65-50(34-16-13-12-14-17-34,35-18-22-37(61-10)23-19-35)36-20-24-38(62-11)25-21-36/h12-14,16-25,29,31-33,39,41-42,46H,15,27-28,30H2,1-11H3,(H2,53,54,55,58,59)/t39-,41-,42-,46-,69?/m1/s1

Synonyms: 2'-OPOM-iBu-G-CE Phosphoramidite; DMT-2'-O-POM-G(iBu)-CE Phosphoramidite; 2'-O-POM Guanosine (iBu) CED phosphoramidite; 2'-O-POM-G(iBu)-3'-phosphoramidite; 5'-O-DMTr-N2-iBu-2'-O-POM-guanosine-3'-CED phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyroyl-2'-O-(pivaloyloxymethyl)guanosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N2-isobutyryl-2'-O-(pivaloyloxymethyl)guanosine 3'-CE phosphoramidite; 5'-O-DMT-2'-O-POM-G(iBu) phosporamidite; DMT-2'-O-POM-rG(iBu) amidite; N2-Isobutyryl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(pivaloyloxymethyl)-Guanosine-3'-CE-Phosphoramidite

N4-Benzoyl-5'-O-DMT-2'-O-propargyl-5-methylcytidine 3'-CE phosphoramidite

Description: N4-Benzoyl-5'-O-DMT-2'-O-propargyl-5-methylcytidine 3'-CE phosphoramidite is a cytidine-derived phosphoramidite building block designed for solid-phase oligonucleotide synthesis, where the ribose carries a 2'-O-propargyl substituent that introduces an alkyne functionality for post-synthetic conjugation via click chemistry. The cytosine base is 5-methyl-substituted for enhanced duplex stability and protected at the exocyclic amino group with a benzoyl (Bz) group, while the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) group and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for efficient stepwise incorporation. This reagent is used in the synthesis of chemically modified oligonucleotides, enabling site-specific labeling, bioconjugation, and structural tuning, while providing enhanced stability, hybridization strength, and versatile functionalization potential for therapeutic and diagnostic applications.

CAT: BRP-02705

Molecular Formula: C50H56N5O9P

Molecular Weight: 901.98

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InChIKey: OJIBJDRBHLCQGW-BRQQSDFOSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C(C)=C5)=O)[C@H](OCC#C)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H56N5O9P/c1-9-30-60-45-44(64-65(62-31-16-29-51)55(34(2)3)35(4)5)43(63-48(45)54-32-36(6)46(53-49(54)57)52-47(56)37-17-12-10-13-18-37)33-61-50(38-19-14-11-15-20-38,39-21-25-41(58-7)26-22-39)40-23-27-42(59-8)28-24-40/h1,10-15,17-28,32,34-35,43-45,48H,16,30-31,33H2,2-8H3,(H,52,53,56,57)/t43-,44-,45-,48-,65?/m1/s1

Synonyms: 2'-O-propargyl 5-Methylcytidine (n-bz) CED phosphoramidite; 2'-O-Propargyl 5-Me-C(Bz)-3'-phosphoramidite; DMTr-5-Methyl-2'-O-propargyl-rC(Bz)-3'-CE-Phosphoramidite; N4-Bz-5-Methyl-DMT-2'-O-propargyl-C-CE-Phosphoramidite; N4-Benzoyl-5-methyl-5'-O-DMT-2'-O-propargylcytidine 3'-CE phosphoramidite; 2'-O-PA-N4-Bz-5-Me-C Phosphoramidite; 5-Me-DMT-2'-O-PA-C(Bz)-CEP; N4-Benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-cytidine-3'-cyanoethyl phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-propargyl-5-methyl-3,4-dihydrocytidine; 5'-O-DMT-2'-O-PA-MeC(Bz) 3'-CE phosphoramidite; 5'-O-DMT-N4-Benzoyl-5-Methy-2'-O-propargylcytidine 3'-CE phosphoramidite; 2'-O-Allynyl MeC(Bz)-3'-phosphoramidite

2'-O-Propargyl-G(dmf)-CE-Phosphoramidite

Description: 2'-O-Propargyl-G(dmf)-CE-Phosphoramidite is a guanosine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, in which the ribose is modified at the 2'-position with a propargyl group that introduces an alkyne handle for post-synthetic functionalization through click chemistry. The guanine base is protected with a dimethylformamide (dmf) group to block the exocyclic amino position, the 5'-hydroxyl is typically protected with a dimethoxytrityl (DMT) group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for controlled chain elongation. This reagent is widely applied in the preparation of modified RNA and DNA oligonucleotides, where the propargyl moiety enables site-specific conjugation with fluorophores, affinity tags, or other chemical functionalities, while maintaining good hybridization properties and stability for both therapeutic and diagnostic uses.

CAT: BRP-02706

CAS: 210096-46-1

Molecular Formula: C46H55N8O8P

Molecular Weight: 878.95

Purity: ≥98%

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InChIKey: BKQBXSOYIXLAFJ-SLLDXECHSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCC#C)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C46H55N8O8P/c1-10-26-58-41-40(62-63(60-27-14-25-47)54(31(2)3)32(4)5)38(61-44(41)53-30-48-39-42(53)50-45(51-43(39)55)49-29-52(6)7)28-59-46(33-15-12-11-13-16-33,34-17-21-36(56-8)22-18-34)35-19-23-37(57-9)24-20-35/h1,11-13,15-24,29-32,38,40-41,44H,14,26-28H2,2-9H3,(H,50,51,55)/t38-,40-,41-,44-,63?/m1/s1

Synonyms: N2-DMF-5'-O-DMTr-2'-O-propargylguanosine-3'-CED-phosphoramidite; N2-Dimethylformamide-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-guanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N2-dimethylformamide-2'-O-propynylguanosine 3'-CE phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-N-dimethylformamide-2'-O-2-propyn-1-ylguanosine; DMTr-2'-O-propargyl-rG(dmf)-3'-CE-Phosphoramidite; 5'-O-DMT-2'-O-Propargyl-N2-dimethylformamide-Guanosine 3'-CE phosphoramidite; N2-DMF-5'-O-DMT-2'-O-propargyl-G-CE-Phosphoramidite; 2'-O-propargyl Guanosine (n-dmf) CED phosphoramidite; 2'-O-Propargyl G(DMF)-3'-phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-2-propynyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

DMTr-2'-O-Propargyl-5-Me-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Propargyl-5-Me-rU-3'-CE-Phosphoramidite is a uridine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, in which the ribose carries a 2'-O-propargyl substituent that introduces an alkyne group for post-synthetic click chemistry conjugation. The nucleobase is 5-methyluridine (5-Me-rU), providing enhanced base stacking and thermal stability in duplexes. The 5'-hydroxyl is protected with a dimethoxytrityl (DMTr) group, while the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite, enabling efficient coupling during automated synthesis. This reagent is widely applied in the preparation of modified oligonucleotides, where the combination of 5-methyl modification and a propargyl handle offers improved stability, stronger hybridization affinity, and versatile options for site-specific labeling or conjugation in therapeutic, diagnostic, and chemical biology applications.

CAT: BRP-02707

CAS: 860640-63-7

Molecular Formula: C43H51N4O9P

Molecular Weight: 798.86

Purity: 98%

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InChIKey: PNFYZUCIYIQEFT-DRQVPZTESA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCC#C

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-4-prop-2-ynoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C43H51N4O9P/c1-9-25-52-39-38(56-57(54-26-13-24-44)47(29(2)3)30(4)5)37(55-41(39)46-27-31(6)40(48)45-42(46)49)28-53-43(32-14-11-10-12-15-32,33-16-20-35(50-7)21-17-33)34-18-22-36(51-8)23-19-34/h1,10-12,14-23,27,29-30,37-39,41H,13,25-26,28H2,2-8H3,(H,45,48,49)/t37-,38-,39-,41-,57?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-2-propyn-1-yl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-O-Propargyl T-3'-phosphoramidite; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMT-2'-O-propynyl-5-methyluridine 3'-CE phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-yl-5-methyluridine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-propargyl-5-methyl-U-3'-phosphoramidite; 5'-O-DMTr-2'-O-propygyl-5-methyluridine 3-CED phosphoramidite; DMT-2'-O-propargyl-5-methyl-U-CE-Phosphoramidite; 2'-O-propargyl 5-methyl Uridine CED phosphoramidite

5'-O-DMT-2'-O-propargylinosine 3'-CE phosphoramidite

Description: 5'-O-DMT-2'-O-propargylinosine 3'-CE phosphoramidite is an inosine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, featuring a 2'-O-propargyl modification on the ribose that introduces an alkyne functionality for post-synthetic conjugation via click chemistry. The inosine base is left unprotected to preserve pairing versatility, while the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) group and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for stepwise incorporation. This reagent is used in the synthesis of chemically modified oligonucleotides, allowing site-specific attachment of probes, fluorophores, or affinity tags, while inosine contributes to wobble base-pairing properties that can modulate hybridization flexibility in therapeutic, diagnostic, and molecular biology applications.

CAT: BRP-02708

Molecular Formula: C43H49N6O8P

Molecular Weight: 808.87

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InChIKey: AHICCCJQTUVLMC-PGHUPTSKSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC=N6)=O)[C@H](OCC#C)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H49N6O8P/c1-8-24-53-39-38(57-58(55-25-12-23-44)49(29(2)3)30(4)5)36(56-42(39)48-28-47-37-40(48)45-27-46-41(37)50)26-54-43(31-13-10-9-11-14-31,32-15-19-34(51-6)20-16-32)33-17-21-35(52-7)22-18-33/h1,9-11,13-22,27-30,36,38-39,42H,12,24-26H2,2-7H3,(H,45,46,50)/t36-,38-,39-,42-,58?/m1/s1

Synonyms: 2'-O-Propargyl I-3'-phosphoramidite; 2'-O-propargyl-5'-O-DMT-inosine 3'-CE phosphoramidite; 2'-O-Propargyl-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)inosine; Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-propargyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-propargylinosine; DMT-2'-O-PA-I-CE-Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-propargyl-inosine-3'-cyanoethyl Phosphoramidite

C22-TEG Phosphoramidite

Description: C22-TEG Phosphoramidite is a non-nucleosidic building block for solid-phase oligonucleotide synthesis, in which a C22 long hydrophobic alkyl chain is combined with a triethylene glycol (TEG) hydrophilic spacer and terminated with a phosphoramidite group for incorporation. Through the hydrophobic interaction of the C22 chain and the water-soluble spacing effect of TEG, it modifies oligonucleotides to enhance cellular uptake and improve circulation stability in vivo, making it particularly useful for nucleic acid drug delivery applications.

CAT: BRP-02709

CAS: 3030325-84-6

Molecular Formula: C64H104N3O10P

Molecular Weight: 1106.52

Purity: ≥97%

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Boiling Point: 989.584±65.00 °C at 760 mmHg

InChIKey: QQJACVOPURNBIP-UHFFFAOYSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCCCCCCC(=O)NCCCOCCOCCOCCOCC(COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[3-[2-[2-[2-[3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropoxy]ethoxy]ethoxy]ethoxy]propyl]docosanamide

InChI: InChI=1S/C64H104N3O10P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-29-34-63(68)66-44-31-45-71-47-48-72-49-50-73-51-52-74-53-62(77-78(76-46-30-43-65)67(55(2)3)56(4)5)54-75-64(57-32-27-26-28-33-57,58-35-39-60(69-6)40-36-58)59-37-41-61(70-7)42-38-59/h26-28,32-33,35-42,55-56,62H,8-25,29-31,34,44-54H2,1-7H3,(H,66,68)

Synonyms: 1,1-Bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azahentetracontan-4-yl (2-cyanoethyl) diisopropylphosphoramidite

C18-TEG Phosphoramidite

Description: C18-TEG Phosphoramidite is a non-nucleosidic building block for solid-phase oligonucleotide synthesis, consisting of a hydrophobic C18 alkyl chain linked to a hydrophilic triethylene glycol (TEG) spacer and terminated with a phosphoramidite group for incorporation into oligonucleotides. By combining the membrane-interacting property of the C18 long chain with the solubilizing and flexible features of TEG, this monomer enhances oligonucleotide amphiphilicity, improves cellular uptake, and increases circulation stability in vivo. It is commonly used in nucleic acid drug delivery, probe design, and functional conjugates where balanced hydrophobicity and hydrophilicity are required for optimized biological performance.

CAT: BRP-02710

Molecular Formula: C60H96N3O10P

Molecular Weight: 1050.41

Purity: ≥97%

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InChIKey: SPGJSJKYGFDRAY-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OC(COCCOCCOCCOCCCNC(CCCCCCCCCCCCCCCCC)=O)COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)OCCC#N)C

InChI: InChI=1S/C60H96N3O10P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-30-59(64)62-40-27-41-67-43-44-68-45-46-69-47-48-70-49-58(73-74(72-42-26-39-61)63(51(2)3)52(4)5)50-71-60(53-28-23-22-24-29-53,54-31-35-56(65-6)36-32-54)55-33-37-57(66-7)38-34-55/h22-24,28-29,31-38,51-52,58H,8-21,25-27,30,40-50H2,1-7H3,(H,62,64)

Synonyms: 1,1-Bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azaheptatriacontan-4-yl (2-cyanoethyl) diisopropylphosphoramidite

6-Hexynyl Phosphoramidite

Description: 6-Hexynyl Phosphoramidite is a non-nucleosidic phosphoramidite building block for solid-phase oligonucleotide synthesis, featuring a six-carbon alkyl chain terminated with a terminal alkyne group and functionalized as a phosphoramidite for incorporation. The terminal alkyne serves as a versatile reactive handle for post-synthetic conjugation through click chemistry with azides, enabling efficient attachment of fluorophores, affinity tags, lipophilic groups, or other functional moieties. This reagent is widely used to prepare site-specifically labeled or functionalized oligonucleotides for applications in diagnostics, molecular probes, nanotechnology, and therapeutic nucleic acid conjugates.

CAT: BRP-02711

CAS: 1438277-11-2

Molecular Formula: C16H29N2O2P

Molecular Weight: 312.39

Purity: ≥98%

Appearance: Colorless oily liquid

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Storage: Store at -20 °C

Boiling Point: 355.5±27.0 °C at 760 mmHg

InChIKey: UJCQKECUXQQDCI-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCC#C)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-hept-6-ynoxyphosphanyl]oxypropanenitrile

InChI: InChI=1S/C16H29N2O2P/c1-6-7-8-9-10-13-19-21(20-14-11-12-17)18(15(2)3)16(4)5/h1,15-16H,7-11,13-14H2,2-5H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 6-heptyn-1-yl ester; 2-Cyanoethyl hept-6-yn-1-yl diisopropylphosphoramidite; 6-Heptyn-1-ol Phosphonamidite; 2-Cyanoethyl 6-heptyn-1-yl N,N-bis(1-methylethyl)phosphoramidite

Heptynoic-TEG Phosphoramidite

Description: Heptynoic-TEG Phosphoramidite is a terminal alkyne–functionalized non-nucleosidic monomer containing both a heptynoic acid–derived alkyne group and a triethylene glycol (TEG) spacer. The TEG unit increases hydrophilicity and molecular flexibility, while the terminal alkyne serves as a reactive handle for click chemistry with azide groups. This design makes it highly useful for site-specific biomolecular labeling, probe functionalization, and the synthesis of advanced functional materials in nucleic acid research and therapeutic applications.

CAT: BRP-02712

Molecular Formula: C49H70N3O10P

Molecular Weight: 892.08

Purity: ≥97%

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InChIKey: JDYJPESYDNYXQH-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OC(COCCOCCOCCOCCCNC(CCCCC#C)=O)COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)OCCC#N)C

InChI: InChI=1S/C49H70N3O10P/c1-8-9-10-14-19-48(53)51-29-16-30-56-32-33-57-34-35-58-36-37-59-38-47(62-63(61-31-15-28-50)52(40(2)3)41(4)5)39-60-49(42-17-12-11-13-18-42,43-20-24-45(54-6)25-21-43)44-22-26-46(55-7)27-23-44/h1,11-13,17-18,20-27,40-41,47H,9-10,14-16,19,29-39H2,2-7H3,(H,51,53)

Synonyms: 1,1-Bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azahexacos-25-yn-4-yl (2-cyanoethyl) diisopropylphosphoramidite

3-((Bis(diisopropylamino)phosphaneyl)oxy)-3-methylbutanenitrile

Description: 3-((Bis(diisopropylamino)phosphaneyl)oxy)-3-methylbutanenitrile is a widely used phosphitylating reagent in oligonucleotide synthesis, and it serves as a key intermediate for preparing nucleoside phosphoramidites. Structurally, it contains a phosphoramidite core with two diisopropylamino substituents for stability and reactivity, and a 2-cyanoethyl moiety (introduced via 3-methylbutanenitrile) that acts as a protecting group for the phosphate linkage during automated DNA/RNA synthesis. This reagent enables the stepwise formation of internucleotide phosphite triesters, which are subsequently oxidized or sulfurized to yield stable phosphodiester or phosphorothioate linkages. It is essential in the large-scale chemical synthesis of DNA, RNA, and modified oligonucleotides for therapeutic, diagnostic, and research applications.

CAT: BRP-02713

CAS: 103930-70-7

Molecular Formula: C17H36N3OP

Molecular Weight: 329.46

Purity: 98%

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Boiling Point: 392.3±44.0 °C at 760 mmHg

InChIKey: UOOJYQBGNXKNTM-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(N(C(C)C)C(C)C)OC(C)(C)CC#N

IUPAC Name: 3-bis[di(propan-2-yl)amino]phosphanyloxy-3-methylbutanenitrile

InChI: InChI=1S/C17H36N3OP/c1-13(2)19(14(3)4)22(20(15(5)6)16(7)8)21-17(9,10)11-12-18/h13-16H,11H2,1-10H3

Synonyms: Dimethylpropionitrile P-reagent; Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyano-1,1-dimethylethyl ester; 3-((Bis(diisopropylamino)phosphino)oxy)-3-methylbutanenitrile

N,N,N',N'-Tetraisopropyl-1-(pent-4-yn-1-yloxy)phosphanediamine

Description: N,N,N',N'-Tetraisopropyl-1-(pent-4-yn-1-yloxy)phosphanediamine is an organophosphorus reagent belonging to the phosphoramidite family, structurally composed of a phosphorus atom bound to two diisopropylamino groups and an alkyloxy substituent bearing a terminal alkyne (pent-4-yn-1-yloxy). This design makes it a phosphitylating reagent for the preparation of alkyne-functionalized nucleoside phosphoramidites. The terminal alkyne provides a reactive handle for post-synthetic modification via copper-catalyzed azide–alkyne cycloaddition (click chemistry), enabling efficient conjugation with fluorophores, affinity tags, lipids, or other functional groups. It is primarily used in oligonucleotide synthesis to introduce site-specific alkyne moieties, supporting the generation of labeled probes, therapeutic conjugates, and functional nucleic acid materials.

CAT: BRP-02714

CAS: 956093-26-8

Molecular Formula: C17H35N2OP

Molecular Weight: 314.45

Purity: 98%

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Boiling Point: 359.7±44.0 °C at 760 mmHg

InChIKey: JLEFIXOQYQOBPA-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(N(C(C)C)C(C)C)OCCCC#C

IUPAC Name: N-[[di(propan-2-yl)amino]-pent-4-ynoxyphosphanyl]-N-propan-2-ylpropan-2-amine

InChI: InChI=1S/C17H35N2OP/c1-10-11-12-13-20-21(18(14(2)3)15(4)5)19(16(6)7)17(8)9/h1,14-17H,11-13H2,2-9H3

Synonyms: Pentyne P-reagent; Phosphorodiamidous acid, N,N,N',N'-tetrakis(1-methylethyl)-, 4-pentyn-1-yl ester; N,N,N',N'-Tetraisopropyl-1-(pent-4-yn-1-yloxy)phosphinediamine

2'-F-dG(dmf)-ANA-CE-Phosphoramidite

Description: 2'-F-dG(dmf)-ANA-CE-Phosphoramidite is a phosphoramidite derivative in which deoxyguanosine is modified with a 2'-fluoro group, an N2-dimethylformamidine (dmf) protecting group, and an arabinonucleic acid (ANA) configuration, combined with a cyanoethyl (CE) phosphoramidite. It is used in automated solid-phase oligonucleotide synthesis, where the 2'-F-ANA modification enhances nuclease resistance, binding affinity, and structural stability in therapeutic and diagnostic nucleic acid applications.

CAT: BRP-02715

CAS: 1391913-24-8

Molecular Formula: C43H52FN8O7P

Molecular Weight: 842.89

Purity: ≥98%

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Storage: Store at -20 °C, under inert atmosphere

Boiling Point: 878.1±75.0 °C at 760 mmHg

InChIKey: BUKKJOTXODUNQK-ZZRCLNINSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@H]1F)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C43H52FN8O7P/c1-28(2)52(29(3)4)60(57-24-12-23-45)59-38-35(58-41(36(38)44)51-27-46-37-39(51)48-42(49-40(37)53)47-26-50(5)6)25-56-43(30-13-10-9-11-14-30,31-15-19-33(54-7)20-16-31)32-17-21-34(55-8)22-18-32/h9-11,13-22,26-29,35-36,38,41H,12,24-25H2,1-8H3,(H,48,49,53)/t35-,36+,38-,41-,60?/m1/s1

Synonyms: (2R,3R,4S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 6H-Purin-6-one, 9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-2-[[(dimethylamino)methylene]amino]-3,9-dihydro-; 9-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl}-2-{[(dimethylamino)methylene]amino}-3,9-dihydro-6H-purin-6-one; Methanimidamide, N'-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethyl-; N'-[9-[(2R,3S,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-3-fluoro-tetrahydrofuran-2-yl]-6-oxo-3H-purin-2-yl]-N,N-dimethyl-formamidine; DMTr-2'-ara-F-dG(dmf)-3'-CE-Phosphoramidite

DMTr-2'-O-C16-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-rC(Bz)-3'-CE-Phosphoramidite is a phosphoramidite in which cytidine is modified at the 2'-hydroxyl with a hexadecyl (C16) long-chain group, the nucleobase is protected with a benzoyl (Bz) group, the 5'-hydroxyl is masked with a dimethoxytrityl (DMTr) group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite. It is used in solid-phase RNA synthesis to introduce hydrophobic C16 modifications, enhancing cellular uptake, membrane interaction, and in vivo stability of oligonucleotides for therapeutic and delivery applications.

CAT: BRP-02716

Molecular Formula: C62H84N5O9P

Molecular Weight: 1074.35

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InChIKey: ASNHBPZQGFGZRD-REAJLHOTSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C=C5)=O)[C@H](OCCCCCCCCCCCCCCCC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C62H84N5O9P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-27-44-72-58-57(76-77(74-45-28-42-63)67(47(2)3)48(4)5)55(75-60(58)66-43-41-56(65-61(66)69)64-59(68)49-29-23-21-24-30-49)46-73-62(50-31-25-22-26-32-50,51-33-37-53(70-6)38-34-51)52-35-39-54(71-7)40-36-52/h21-26,29-41,43,47-48,55,57-58,60H,8-20,27-28,44-46H2,1-7H3,(H,64,65,68,69)/t55-,57-,58-,60-,77?/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(hexadecyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-O-C16-C(Bz) phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Bz-5'-O-DMTr-2'-O-hexadecanyl cytidine 3'-CED phosphoramidite

DMTr-2'-O-C16-5-Me-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-5-Me-rC(Bz)-3'-CE-Phosphoramidite is a phosphoramidite in which 5-methylcytidine is modified with a 2'-O-hexadecyl (C16) group, the nucleobase is protected with a benzoyl (Bz) group, the 5'-hydroxyl is masked with a dimethoxytrityl (DMTr) group, and the 3'-hydroxyl carries a cyanoethyl (CE) phosphoramidite for incorporation. This monomer is employed in solid-phase RNA synthesis to introduce hydrophobic C16 modifications, enhancing membrane affinity, cellular uptake, and in vivo stability of oligonucleotides for therapeutic and delivery applications.

CAT: BRP-02717

Molecular Formula: C63H86N5O9P

Molecular Weight: 1088.38

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InChIKey: MNUWXOZZJCGTRG-GNSLXPLHSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C(C)=C5)=O)[C@H](OCCCCCCCCCCCCCCCC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C63H86N5O9P/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-28-43-73-58-57(77-78(75-44-29-42-64)68(47(2)3)48(4)5)56(76-61(58)67-45-49(6)59(66-62(67)70)65-60(69)50-30-24-22-25-31-50)46-74-63(51-32-26-23-27-33-51,52-34-38-54(71-7)39-35-52)53-36-40-55(72-8)41-37-53/h22-27,30-41,45,47-48,56-58,61H,9-21,28-29,43-44,46H2,1-8H3,(H,65,66,69,70)/t56-,57-,58-,61-,78?/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(4-Benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(hexadecyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-O-C16-5-Me-C(Bz) phosphoramidite; Cytidine, N-benzoyl-5-methyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Bz-5'-O-DMTr-2'-O-hexadecanyl 5-methylcytidine 3'-CED phosphoramidite

DMTr-2'-O-C16-I-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-I-3'-CE-Phosphoramidite is a phosphoramidite in which the 2'-hydroxyl of the nucleoside is modified with a hexadecyl (C16) iodide (I) group, the 5'-hydroxyl is protected with a dimethoxytrityl (DMTr) group, and the 3'-position carries a cyanoethyl (CE) phosphoramidite for incorporation. This monomer is used in solid-phase oligonucleotide synthesis to introduce hydrophobic C16-I modifications, enhancing membrane affinity, cellular uptake, and in vivo stability of therapeutic oligonucleotides.

CAT: BRP-02718

Molecular Formula: C56H79N6O8P

Molecular Weight: 995.26

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InChIKey: PXUIVBRTHJTMLD-IFGGAQLVSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC=N6)=O)[C@H](OCCCCCCCCCCCCCCCC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C56H79N6O8P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-24-37-66-52-51(70-71(68-38-25-36-57)62(42(2)3)43(4)5)49(69-55(52)61-41-60-50-53(61)58-40-59-54(50)63)39-67-56(44-26-22-21-23-27-44,45-28-32-47(64-6)33-29-45)46-30-34-48(65-7)35-31-46/h21-23,26-35,40-43,49,51-52,55H,8-20,24-25,37-39H2,1-7H3,(H,58,59,63)/t49-,51-,52-,55-,71?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(hexadecyloxy)-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMTr-2'-O-hexadecanyl inosine 3'-CED phosphoramidite; 2'-O-C16-I phosphoramidite

CN-LNA-G(iBu)-CE Phosphoramidite

CN-LNA-5-MeU-CE Phosphoramidite

5'-O-DMT-2'-O-POM-U-3'-CE-Phosphoramidite

5'-O-DMT-2'-O-POM-A(Bz)-3'-CE-Phosphoramidite

5'-O-DMT-2'-O-POM-C(Ac)-3'-CE-Phosphoramidite

5'-O-DMT-2'-O-POM-G(iBu)-3'-CE-Phosphoramidite

N4-Benzoyl-5'-O-DMT-2'-O-propargyl-5-methylcytidine 3'-CE phosphoramidite

2'-O-Propargyl-G(dmf)-CE-Phosphoramidite

DMTr-2'-O-Propargyl-5-Me-rU-3'-CE-Phosphoramidite

5'-O-DMT-2'-O-propargylinosine 3'-CE phosphoramidite

C22-TEG Phosphoramidite

C18-TEG Phosphoramidite

6-Hexynyl Phosphoramidite

Heptynoic-TEG Phosphoramidite

3-((Bis(diisopropylamino)phosphaneyl)oxy)-3-methylbutanenitrile

N,N,N',N'-Tetraisopropyl-1-(pent-4-yn-1-yloxy)phosphanediamine

2'-F-dG(dmf)-ANA-CE-Phosphoramidite

DMTr-2'-O-C16-rC(Bz)-3'-CE-Phosphoramidite

DMTr-2'-O-C16-5-Me-rC(Bz)-3'-CE-Phosphoramidite

DMTr-2'-O-C16-I-3'-CE-Phosphoramidite

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