What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

DMTr-2'-O-Propargyl-5-Me-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Propargyl-5-Me-rU-3'-CE-Phosphoramidite is a uridine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, in which the ribose carries a 2'-O-propargyl substituent that introduces an alkyne group for post-synthetic click chemistry conjugation. The nucleobase is 5-methyluridine (5-Me-rU), providing enhanced base stacking and thermal stability in duplexes. The 5'-hydroxyl is protected with a dimethoxytrityl (DMTr) group, while the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite, enabling efficient coupling during automated synthesis. This reagent is widely applied in the preparation of modified oligonucleotides, where the combination of 5-methyl modification and a propargyl handle offers improved stability, stronger hybridization affinity, and versatile options for site-specific labeling or conjugation in therapeutic, diagnostic, and chemical biology applications.

CAT: BRP-02707

CAS: 860640-63-7

Molecular Formula: C43H51N4O9P

Molecular Weight: 798.86

Purity: 98%

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: PNFYZUCIYIQEFT-DRQVPZTESA-N

SMILES: CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCC#C

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-4-prop-2-ynoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C43H51N4O9P/c1-9-25-52-39-38(56-57(54-26-13-24-44)47(29(2)3)30(4)5)37(55-41(39)46-27-31(6)40(48)45-42(46)49)28-53-43(32-14-11-10-12-15-32,33-16-20-35(50-7)21-17-33)34-18-22-36(51-8)23-19-34/h1,10-12,14-23,27,29-30,37-39,41H,13,25-26,28H2,2-8H3,(H,45,48,49)/t37-,38-,39-,41-,57?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-2-propyn-1-yl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-O-Propargyl T-3'-phosphoramidite; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMT-2'-O-propynyl-5-methyluridine 3'-CE phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-yl-5-methyluridine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-propargyl-5-methyl-U-3'-phosphoramidite; 5'-O-DMTr-2'-O-propygyl-5-methyluridine 3-CED phosphoramidite; DMT-2'-O-propargyl-5-methyl-U-CE-Phosphoramidite; 2'-O-propargyl 5-methyl Uridine CED phosphoramidite

5'-O-DMT-2'-O-propargylinosine 3'-CE phosphoramidite

Description: 5'-O-DMT-2'-O-propargylinosine 3'-CE phosphoramidite is an inosine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, featuring a 2'-O-propargyl modification on the ribose that introduces an alkyne functionality for post-synthetic conjugation via click chemistry. The inosine base is left unprotected to preserve pairing versatility, while the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) group and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for stepwise incorporation. This reagent is used in the synthesis of chemically modified oligonucleotides, allowing site-specific attachment of probes, fluorophores, or affinity tags, while inosine contributes to wobble base-pairing properties that can modulate hybridization flexibility in therapeutic, diagnostic, and molecular biology applications.

CAT: BRP-02708

Molecular Formula: C43H49N6O8P

Molecular Weight: 808.87

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: AHICCCJQTUVLMC-PGHUPTSKSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC=N6)=O)[C@H](OCC#C)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H49N6O8P/c1-8-24-53-39-38(57-58(55-25-12-23-44)49(29(2)3)30(4)5)36(56-42(39)48-28-47-37-40(48)45-27-46-41(37)50)26-54-43(31-13-10-9-11-14-31,32-15-19-34(51-6)20-16-32)33-17-21-35(52-7)22-18-33/h1,9-11,13-22,27-30,36,38-39,42H,12,24-26H2,2-7H3,(H,45,46,50)/t36-,38-,39-,42-,58?/m1/s1

Synonyms: 2'-O-Propargyl I-3'-phosphoramidite; 2'-O-propargyl-5'-O-DMT-inosine 3'-CE phosphoramidite; 2'-O-Propargyl-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)inosine; Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-propargyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-propargylinosine; DMT-2'-O-PA-I-CE-Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-propargyl-inosine-3'-cyanoethyl Phosphoramidite

C22-TEG Phosphoramidite

Description: C22-TEG Phosphoramidite is a non-nucleosidic building block for solid-phase oligonucleotide synthesis, in which a C22 long hydrophobic alkyl chain is combined with a triethylene glycol (TEG) hydrophilic spacer and terminated with a phosphoramidite group for incorporation. Through the hydrophobic interaction of the C22 chain and the water-soluble spacing effect of TEG, it modifies oligonucleotides to enhance cellular uptake and improve circulation stability in vivo, making it particularly useful for nucleic acid drug delivery applications.

CAT: BRP-02709

CAS: 3030325-84-6

Molecular Formula: C64H104N3O10P

Molecular Weight: 1106.52

Purity: ≥97%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Boiling Point: 989.584±65.00 °C at 760 mmHg

InChIKey: QQJACVOPURNBIP-UHFFFAOYSA-N

SMILES: CCCCCCCCCCCCCCCCCCCCCC(=O)NCCCOCCOCCOCCOCC(COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[3-[2-[2-[2-[3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropoxy]ethoxy]ethoxy]ethoxy]propyl]docosanamide

InChI: InChI=1S/C64H104N3O10P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-29-34-63(68)66-44-31-45-71-47-48-72-49-50-73-51-52-74-53-62(77-78(76-46-30-43-65)67(55(2)3)56(4)5)54-75-64(57-32-27-26-28-33-57,58-35-39-60(69-6)40-36-58)59-37-41-61(70-7)42-38-59/h26-28,32-33,35-42,55-56,62H,8-25,29-31,34,44-54H2,1-7H3,(H,66,68)

Synonyms: 1,1-Bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azahentetracontan-4-yl (2-cyanoethyl) diisopropylphosphoramidite

C18-TEG Phosphoramidite

Description: C18-TEG Phosphoramidite is a non-nucleosidic building block for solid-phase oligonucleotide synthesis, consisting of a hydrophobic C18 alkyl chain linked to a hydrophilic triethylene glycol (TEG) spacer and terminated with a phosphoramidite group for incorporation into oligonucleotides. By combining the membrane-interacting property of the C18 long chain with the solubilizing and flexible features of TEG, this monomer enhances oligonucleotide amphiphilicity, improves cellular uptake, and increases circulation stability in vivo. It is commonly used in nucleic acid drug delivery, probe design, and functional conjugates where balanced hydrophobicity and hydrophilicity are required for optimized biological performance.

CAT: BRP-02710

Molecular Formula: C60H96N3O10P

Molecular Weight: 1050.41

Purity: ≥97%

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: SPGJSJKYGFDRAY-UHFFFAOYSA-N

SMILES: CC(N(C(C)C)P(OC(COCCOCCOCCOCCCNC(CCCCCCCCCCCCCCCCC)=O)COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)OCCC#N)C

InChI: InChI=1S/C60H96N3O10P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-30-59(64)62-40-27-41-67-43-44-68-45-46-69-47-48-70-49-58(73-74(72-42-26-39-61)63(51(2)3)52(4)5)50-71-60(53-28-23-22-24-29-53,54-31-35-56(65-6)36-32-54)55-33-37-57(66-7)38-34-55/h22-24,28-29,31-38,51-52,58H,8-21,25-27,30,40-50H2,1-7H3,(H,62,64)

Synonyms: 1,1-Bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azaheptatriacontan-4-yl (2-cyanoethyl) diisopropylphosphoramidite

6-Hexynyl Phosphoramidite

Description: 6-Hexynyl Phosphoramidite is a non-nucleosidic phosphoramidite building block for solid-phase oligonucleotide synthesis, featuring a six-carbon alkyl chain terminated with a terminal alkyne group and functionalized as a phosphoramidite for incorporation. The terminal alkyne serves as a versatile reactive handle for post-synthetic conjugation through click chemistry with azides, enabling efficient attachment of fluorophores, affinity tags, lipophilic groups, or other functional moieties. This reagent is widely used to prepare site-specifically labeled or functionalized oligonucleotides for applications in diagnostics, molecular probes, nanotechnology, and therapeutic nucleic acid conjugates.

CAT: BRP-02711

CAS: 1438277-11-2

Molecular Formula: C16H29N2O2P

Molecular Weight: 312.39

Purity: ≥98%

Appearance: Colorless oily liquid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

Boiling Point: 355.5±27.0 °C at 760 mmHg

InChIKey: UJCQKECUXQQDCI-UHFFFAOYSA-N

SMILES: CC(C)N(C(C)C)P(OCCCCCC#C)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-hept-6-ynoxyphosphanyl]oxypropanenitrile

InChI: InChI=1S/C16H29N2O2P/c1-6-7-8-9-10-13-19-21(20-14-11-12-17)18(15(2)3)16(4)5/h1,15-16H,7-11,13-14H2,2-5H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 6-heptyn-1-yl ester; 2-Cyanoethyl hept-6-yn-1-yl diisopropylphosphoramidite; 6-Heptyn-1-ol Phosphonamidite; 2-Cyanoethyl 6-heptyn-1-yl N,N-bis(1-methylethyl)phosphoramidite

Heptynoic-TEG Phosphoramidite

Description: Heptynoic-TEG Phosphoramidite is a terminal alkyne–functionalized non-nucleosidic monomer containing both a heptynoic acid–derived alkyne group and a triethylene glycol (TEG) spacer. The TEG unit increases hydrophilicity and molecular flexibility, while the terminal alkyne serves as a reactive handle for click chemistry with azide groups. This design makes it highly useful for site-specific biomolecular labeling, probe functionalization, and the synthesis of advanced functional materials in nucleic acid research and therapeutic applications.

CAT: BRP-02712

Molecular Formula: C49H70N3O10P

Molecular Weight: 892.08

Purity: ≥97%

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: JDYJPESYDNYXQH-UHFFFAOYSA-N

SMILES: CC(N(C(C)C)P(OC(COCCOCCOCCOCCCNC(CCCCC#C)=O)COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)OCCC#N)C

InChI: InChI=1S/C49H70N3O10P/c1-8-9-10-14-19-48(53)51-29-16-30-56-32-33-57-34-35-58-36-37-59-38-47(62-63(61-31-15-28-50)52(40(2)3)41(4)5)39-60-49(42-17-12-11-13-18-42,43-20-24-45(54-6)25-21-43)44-22-26-46(55-7)27-23-44/h1,11-13,17-18,20-27,40-41,47H,9-10,14-16,19,29-39H2,2-7H3,(H,51,53)

Synonyms: 1,1-Bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azahexacos-25-yn-4-yl (2-cyanoethyl) diisopropylphosphoramidite

3-((Bis(diisopropylamino)phosphaneyl)oxy)-3-methylbutanenitrile

Description: 3-((Bis(diisopropylamino)phosphaneyl)oxy)-3-methylbutanenitrile is a widely used phosphitylating reagent in oligonucleotide synthesis, and it serves as a key intermediate for preparing nucleoside phosphoramidites. Structurally, it contains a phosphoramidite core with two diisopropylamino substituents for stability and reactivity, and a 2-cyanoethyl moiety (introduced via 3-methylbutanenitrile) that acts as a protecting group for the phosphate linkage during automated DNA/RNA synthesis. This reagent enables the stepwise formation of internucleotide phosphite triesters, which are subsequently oxidized or sulfurized to yield stable phosphodiester or phosphorothioate linkages. It is essential in the large-scale chemical synthesis of DNA, RNA, and modified oligonucleotides for therapeutic, diagnostic, and research applications.

CAT: BRP-02713

CAS: 103930-70-7

Molecular Formula: C17H36N3OP

Molecular Weight: 329.46

Purity: 98%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Boiling Point: 392.3±44.0 °C at 760 mmHg

InChIKey: UOOJYQBGNXKNTM-UHFFFAOYSA-N

SMILES: CC(C)N(C(C)C)P(N(C(C)C)C(C)C)OC(C)(C)CC#N

IUPAC Name: 3-bis[di(propan-2-yl)amino]phosphanyloxy-3-methylbutanenitrile

InChI: InChI=1S/C17H36N3OP/c1-13(2)19(14(3)4)22(20(15(5)6)16(7)8)21-17(9,10)11-12-18/h13-16H,11H2,1-10H3

Synonyms: Dimethylpropionitrile P-reagent; Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyano-1,1-dimethylethyl ester; 3-((Bis(diisopropylamino)phosphino)oxy)-3-methylbutanenitrile

N,N,N',N'-Tetraisopropyl-1-(pent-4-yn-1-yloxy)phosphanediamine

Description: N,N,N',N'-Tetraisopropyl-1-(pent-4-yn-1-yloxy)phosphanediamine is an organophosphorus reagent belonging to the phosphoramidite family, structurally composed of a phosphorus atom bound to two diisopropylamino groups and an alkyloxy substituent bearing a terminal alkyne (pent-4-yn-1-yloxy). This design makes it a phosphitylating reagent for the preparation of alkyne-functionalized nucleoside phosphoramidites. The terminal alkyne provides a reactive handle for post-synthetic modification via copper-catalyzed azide–alkyne cycloaddition (click chemistry), enabling efficient conjugation with fluorophores, affinity tags, lipids, or other functional groups. It is primarily used in oligonucleotide synthesis to introduce site-specific alkyne moieties, supporting the generation of labeled probes, therapeutic conjugates, and functional nucleic acid materials.

CAT: BRP-02714

CAS: 956093-26-8

Molecular Formula: C17H35N2OP

Molecular Weight: 314.45

Purity: 98%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Boiling Point: 359.7±44.0 °C at 760 mmHg

InChIKey: JLEFIXOQYQOBPA-UHFFFAOYSA-N

SMILES: CC(C)N(C(C)C)P(N(C(C)C)C(C)C)OCCCC#C

IUPAC Name: N-[[di(propan-2-yl)amino]-pent-4-ynoxyphosphanyl]-N-propan-2-ylpropan-2-amine

InChI: InChI=1S/C17H35N2OP/c1-10-11-12-13-20-21(18(14(2)3)15(4)5)19(16(6)7)17(8)9/h1,14-17H,11-13H2,2-9H3

Synonyms: Pentyne P-reagent; Phosphorodiamidous acid, N,N,N',N'-tetrakis(1-methylethyl)-, 4-pentyn-1-yl ester; N,N,N',N'-Tetraisopropyl-1-(pent-4-yn-1-yloxy)phosphinediamine

2'-F-dG(dmf)-ANA-CE-Phosphoramidite

Description: 2'-F-dG(dmf)-ANA-CE-Phosphoramidite is a phosphoramidite derivative in which deoxyguanosine is modified with a 2'-fluoro group, an N2-dimethylformamidine (dmf) protecting group, and an arabinonucleic acid (ANA) configuration, combined with a cyanoethyl (CE) phosphoramidite. It is used in automated solid-phase oligonucleotide synthesis, where the 2'-F-ANA modification enhances nuclease resistance, binding affinity, and structural stability in therapeutic and diagnostic nucleic acid applications.

CAT: BRP-02715

CAS: 1391913-24-8

Molecular Formula: C43H52FN8O7P

Molecular Weight: 842.89

Purity: ≥98%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C, under inert atmosphere

Boiling Point: 878.1±75.0 °C at 760 mmHg

InChIKey: BUKKJOTXODUNQK-ZZRCLNINSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@H]1F)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C43H52FN8O7P/c1-28(2)52(29(3)4)60(57-24-12-23-45)59-38-35(58-41(36(38)44)51-27-46-37-39(51)48-42(49-40(37)53)47-26-50(5)6)25-56-43(30-13-10-9-11-14-30,31-15-19-33(54-7)20-16-31)32-17-21-34(55-8)22-18-32/h9-11,13-22,26-29,35-36,38,41H,12,24-25H2,1-8H3,(H,48,49,53)/t35-,36+,38-,41-,60?/m1/s1

Synonyms: (2R,3R,4S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 6H-Purin-6-one, 9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-2-[[(dimethylamino)methylene]amino]-3,9-dihydro-; 9-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl}-2-{[(dimethylamino)methylene]amino}-3,9-dihydro-6H-purin-6-one; Methanimidamide, N'-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethyl-; N'-[9-[(2R,3S,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-3-fluoro-tetrahydrofuran-2-yl]-6-oxo-3H-purin-2-yl]-N,N-dimethyl-formamidine; DMTr-2'-ara-F-dG(dmf)-3'-CE-Phosphoramidite

DMTr-2'-O-C16-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-rC(Bz)-3'-CE-Phosphoramidite is a phosphoramidite in which cytidine is modified at the 2'-hydroxyl with a hexadecyl (C16) long-chain group, the nucleobase is protected with a benzoyl (Bz) group, the 5'-hydroxyl is masked with a dimethoxytrityl (DMTr) group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite. It is used in solid-phase RNA synthesis to introduce hydrophobic C16 modifications, enhancing cellular uptake, membrane interaction, and in vivo stability of oligonucleotides for therapeutic and delivery applications.

CAT: BRP-02716

Molecular Formula: C62H84N5O9P

Molecular Weight: 1074.35

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: ASNHBPZQGFGZRD-REAJLHOTSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C=C5)=O)[C@H](OCCCCCCCCCCCCCCCC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C62H84N5O9P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-27-44-72-58-57(76-77(74-45-28-42-63)67(47(2)3)48(4)5)55(75-60(58)66-43-41-56(65-61(66)69)64-59(68)49-29-23-21-24-30-49)46-73-62(50-31-25-22-26-32-50,51-33-37-53(70-6)38-34-51)52-35-39-54(71-7)40-36-52/h21-26,29-41,43,47-48,55,57-58,60H,8-20,27-28,44-46H2,1-7H3,(H,64,65,68,69)/t55-,57-,58-,60-,77?/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(hexadecyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-O-C16-C(Bz) phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Bz-5'-O-DMTr-2'-O-hexadecanyl cytidine 3'-CED phosphoramidite

DMTr-2'-O-C16-5-Me-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-5-Me-rC(Bz)-3'-CE-Phosphoramidite is a phosphoramidite in which 5-methylcytidine is modified with a 2'-O-hexadecyl (C16) group, the nucleobase is protected with a benzoyl (Bz) group, the 5'-hydroxyl is masked with a dimethoxytrityl (DMTr) group, and the 3'-hydroxyl carries a cyanoethyl (CE) phosphoramidite for incorporation. This monomer is employed in solid-phase RNA synthesis to introduce hydrophobic C16 modifications, enhancing membrane affinity, cellular uptake, and in vivo stability of oligonucleotides for therapeutic and delivery applications.

CAT: BRP-02717

Molecular Formula: C63H86N5O9P

Molecular Weight: 1088.38

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: MNUWXOZZJCGTRG-GNSLXPLHSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C(C)=C5)=O)[C@H](OCCCCCCCCCCCCCCCC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C63H86N5O9P/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-28-43-73-58-57(77-78(75-44-29-42-64)68(47(2)3)48(4)5)56(76-61(58)67-45-49(6)59(66-62(67)70)65-60(69)50-30-24-22-25-31-50)46-74-63(51-32-26-23-27-33-51,52-34-38-54(71-7)39-35-52)53-36-40-55(72-8)41-37-53/h22-27,30-41,45,47-48,56-58,61H,9-21,28-29,43-44,46H2,1-8H3,(H,65,66,69,70)/t56-,57-,58-,61-,78?/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(4-Benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(hexadecyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-O-C16-5-Me-C(Bz) phosphoramidite; Cytidine, N-benzoyl-5-methyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Bz-5'-O-DMTr-2'-O-hexadecanyl 5-methylcytidine 3'-CED phosphoramidite

DMTr-2'-O-C16-I-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-I-3'-CE-Phosphoramidite is a phosphoramidite in which the 2'-hydroxyl of the nucleoside is modified with a hexadecyl (C16) iodide (I) group, the 5'-hydroxyl is protected with a dimethoxytrityl (DMTr) group, and the 3'-position carries a cyanoethyl (CE) phosphoramidite for incorporation. This monomer is used in solid-phase oligonucleotide synthesis to introduce hydrophobic C16-I modifications, enhancing membrane affinity, cellular uptake, and in vivo stability of therapeutic oligonucleotides.

CAT: BRP-02718

Molecular Formula: C56H79N6O8P

Molecular Weight: 995.26

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: PXUIVBRTHJTMLD-IFGGAQLVSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC=N6)=O)[C@H](OCCCCCCCCCCCCCCCC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C56H79N6O8P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-24-37-66-52-51(70-71(68-38-25-36-57)62(42(2)3)43(4)5)49(69-55(52)61-41-60-50-53(61)58-40-59-54(50)63)39-67-56(44-26-22-21-23-27-44,45-28-32-47(64-6)33-29-45)46-30-34-48(65-7)35-31-46/h21-23,26-35,40-43,49,51-52,55H,8-20,24-25,37-39H2,1-7H3,(H,58,59,63)/t49-,51-,52-,55-,71?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(hexadecyloxy)-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMTr-2'-O-hexadecanyl inosine 3'-CED phosphoramidite; 2'-O-C16-I phosphoramidite

DMTr-2'-O-C16-rG(DMF)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-rG(DMF)-3'-CE-Phosphoramidite is a phosphoramidite in which guanosine is protected at the N2 position with a dimethylformamidine (DMF) group, the 5'-hydroxyl with a dimethoxytrityl (DMTr) group, the 3'-position with a cyanoethyl (CE) phosphoramidite, and the 2'-hydroxyl is modified with a hexadecyl (C16) long-chain substituent. It is applied in solid-phase RNA synthesis to introduce hydrophobic C16 lipid-like modifications, which improve membrane interaction, cellular uptake, and in vivo stability of oligonucleotides for therapeutic delivery.

CAT: BRP-02719

Molecular Formula: C59H85N8O8P

Molecular Weight: 1065.35

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: REQILBSOGLPEGS-UVFXKDKVSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N=CN(C)C)=N6)=O)[C@H](OCCCCCCCCCCCCCCCC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C59H85N8O8P/c1-10-11-12-13-14-15-16-17-18-19-20-21-22-26-39-71-54-53(75-76(73-40-27-38-60)67(44(2)3)45(4)5)51(74-57(54)66-43-61-52-55(66)63-58(64-56(52)68)62-42-65(6)7)41-72-59(46-28-24-23-25-29-46,47-30-34-49(69-8)35-31-47)48-32-36-50(70-9)37-33-48/h23-25,28-37,42-45,51,53-54,57H,10-22,26-27,39-41H2,1-9H3,(H,63,64,68)/t51-,53-,54-,57-,76?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(hexadecyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; N2-DMF-5'-O-DMTr-2'-O-hexadecanyl guanosine 3'-CED phosphoramidite; 2'-O-C16-G(DMF) phosphoramidite

GalNAc-THA C6 phosphoramidite

Description: GalNAc-THA C6 phosphoramidite is a reagent used in the synthesis of oligonucleotides.

CAT: BRP-02798

CAS: 2058062-52-3

Molecular Formula: C93H155N10O37P

Molecular Weight: 2036.24

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: AQRSTPBSCQPPBQ-KAKHWKMQSA-N

SMILES: N#CCCOP(N(C(C)C)C(C)C)OCCCCCCNC(CCCC(NC(COCCC(NCCCCCCO[C@H]1[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O1)=O)(COCCC(NCCCCCCO[C@@H]2O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2NC(C)=O)=O)COCCC(NCCCCCCO[C@H]3[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O3)=O)=O)=O

InChI: InChI=1S/C93H155N10O37P/c1-59(2)103(60(3)4)141(131-49-34-40-94)130-48-32-24-20-28-41-95-76(116)35-33-36-80(120)102-93(56-121-50-37-77(117)96-42-25-17-21-29-45-124-90-81(99-61(5)104)87(135-70(14)113)84(132-67(11)110)73(138-90)53-127-64(8)107,57-122-51-38-78(118)97-43-26-18-22-30-46-125-91-82(100-62(6)105)88(136-71(15)114)85(133-68(12)111)74(139-91)54-128-65(9)108)58-123-52-39-79(119)98-44-27-19-23-31-47-126-92-83(101-63(7)106)89(137-72(16)115)86(134-69(13)112)75(140-92)55-129-66(10)109/h59-60,73-75,81-92H,17-39,41-58H2,1-16H3,(H,95,116)(H,96,117)(H,97,118)(H,98,119)(H,99,104)(H,100,105)(H,101,106)(H,102,120)/t73-,74-,75-,81-,82-,83-,84+,85+,86+,87-,88-,89-,90-,91-,92-,141?/m1/s1

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-,2-cyanoethyl8,12,19-trioxo-14,14-bis[[3-oxo-3-[[6-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyChemicalbookranosyl]oxy]hexyl]amino]propoxy]methyl]-26-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-7,13,20-triazahexacos-1-yl ester

DMTr-2'-O-Me-rA(Bz)-3'-(D)-DPSE-Phosphoramidite

Description: DMTr-2'-O-Me-rA(Bz)-3'-(D)-DPSE-Phosphoramidite is a reagent used in the synthesis of oligonucleotides.

CAT: BRP-02799

CAS: 1528733-91-6

Molecular Formula: C58H59N6O8PSi

Molecular Weight: 1027.2

Purity: ≥95%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: YPNIDBLCASOAIX-DVCONZJDSA-N

SMILES: CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O[P@]8N9CCC[C@@H]9[C@@H](O8)C[Si](C)(C1=CC=CC=C1)C1=CC=CC=C1

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[[(1R,3R,3aR)-3-[[methyl(diphenyl)silyl]methyl]-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]oxy]-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-methoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C58H59N6O8PSi/c1-66-44-31-27-42(28-32-44)58(41-20-11-6-12-21-41,43-29-33-45(67-2)34-30-43)69-36-49-52(53(68-3)57(70-49)63-39-61-51-54(59-38-60-55(51)63)62-56(65)40-18-9-5-10-19-40)72-73-64-35-17-26-48(64)50(71-73)37-74(4,46-22-13-7-14-23-46)47-24-15-8-16-25-47/h5-16,18-25,27-34,38-39,48-50,52-53,57H,17,26,35-37H2,1-4H3,(H,59,60,62,65)/t48-,49-,50+,52-,53-,57-,73+/m1/s1

DMTr-2'-O-Me-rU-3'-(D)-DPSE-Phosphoramidite

Description: DMTr-2'-O-Me-rU-3'-(D)-DPSE-Phosphoramidite is a reagent used in the synthesis of oligonucleotides.

CAT: BRP-02800

CAS: 1528733-98-3

Molecular Formula: C50H54N3O9PSi

Molecular Weight: 900.1

Purity: ≥95%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: ZCWZYMJOKSJYRG-BWXFLUKOSA-N

SMILES: CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[P@]6N7CCC[C@@H]7[C@@H](O6)C[Si](C)(C8=CC=CC=C8)C9=CC=CC=C9

IUPAC Name: 1-[(2R,3R,4R,5R)-4-[[(1R,3R,3aR)-3-[[methyl(diphenyl)silyl]methyl]-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]oxy]-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C50H54N3O9PSi/c1-56-38-26-22-36(23-27-38)50(35-15-8-5-9-16-35,37-24-28-39(57-2)29-25-37)59-33-43-46(47(58-3)48(60-43)52-32-30-45(54)51-49(52)55)62-63-53-31-14-21-42(53)44(61-63)34-64(4,40-17-10-6-11-18-40)41-19-12-7-13-20-41/h5-13,15-20,22-30,32,42-44,46-48H,14,21,31,33-34H2,1-4H3,(H,51,54,55)/t42-,43-,44+,46-,47-,48-,63+/m1/s1

DMTr-2'-O-Me-rG(iBu)-3'-(D)-DPSE-Phosphoramidite

Description: DMTr-2'-O-Me-rG(iBu)-3'-(D)-DPSE-Phosphoramidite is a reagent used in the synthesis of oligonucleotides.

CAT: BRP-02801

CAS: 2227139-99-1

Molecular Formula: C55H61N6O9PSi

Molecular Weight: 1009.17

Purity: ≥98%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: OXZJTILABONBRI-ULXZQQBCSA-N

SMILES: CO[C@H]1[C@H](N2C=NC3=C2NC(NC(C(C)C)=O)=NC3=O)O[C@H](COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)[C@H]1O[P@@]7O[C@@H](C[Si](C8=CC=CC=C8)(C)C9=CC=CC=C9)[C@]%10([H])N7CCC%10

InChI: InChI=1S/C55H61N6O9PSi/c1-36(2)51(62)58-54-57-50-47(52(63)59-54)56-35-60(50)53-49(66-5)48(70-71-61-32-16-23-44(61)46(69-71)34-72(6,42-19-12-8-13-20-42)43-21-14-9-15-22-43)45(68-53)33-67-55(37-17-10-7-11-18-37,38-24-28-40(64-3)29-25-38)39-26-30-41(65-4)31-27-39/h7-15,17-22,24-31,35-36,44-46,48-49,53H,16,23,32-34H2,1-6H3,(H2,57,58,59,62,63)/t44-,45-,46+,48-,49-,53-,71+/m1/s1

DMTr-2'-O-Me-rC(Ac)-3'-(D)-DPSE-Phosphoramidite

Description: DMTr-2'-O-Me-rC(Ac)-3'-(D)-DPSE-Phosphoramidite is a reagent used in the synthesis of oligonucleotides.

CAT: BRP-02802

Molecular Formula: C52H57N4O9PSi

Molecular Weight: 941.11

Purity: ≥98%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: ZIOMTJMQNMQHET-WUGSJAFOSA-N

SMILES: CO[C@H]1[C@H](N2C(N=C(NC(C)=O)C=C2)=O)O[C@H](COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5)[C@H]1O[P@@]6O[C@@H](C[Si](C7=CC=CC=C7)(C)C8=CC=CC=C8)[C@]9([H])N6CCC9

InChI: InChI=1S/C52H57N4O9PSi/c1-36(57)53-47-31-33-55(51(58)54-47)50-49(61-4)48(65-66-56-32-15-22-44(56)46(64-66)35-67(5,42-18-11-7-12-19-42)43-20-13-8-14-21-43)45(63-50)34-62-52(37-16-9-6-10-17-37,38-23-27-40(59-2)28-24-38)39-25-29-41(60-3)30-26-39/h6-14,16-21,23-31,33,44-46,48-50H,15,22,32,34-35H2,1-5H3,(H,53,54,57,58)/t44-,45-,46+,48-,49-,50-,66+/m1/s1

DMTr-2'-O-Me-rC(Bz)-3'-(D)-DPSE-Phosphoramidite

Description: DMTr-2'-O-Me-rC(Bz)-3'-(D)-DPSE-Phosphoramidite is a reagent used in the synthesis of oligonucleotides.

CAT: BRP-02803

Molecular Formula: C57H59N4O9PSi

Molecular Weight: 1003.18

Purity: ≥98%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: NWFPCSOOQFYGSM-YRMZABOLSA-N

SMILES: CO[C@H]1[C@H](N2C(N=C(NC(C3=CC=CC=C3)=O)C=C2)=O)O[C@H](COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)[C@H]1O[P@@]7O[C@@H](C[Si](C8=CC=CC=C8)(C)C9=CC=CC=C9)[C@]%10([H])N7CCC%10

InChI: InChI=1S/C57H59N4O9PSi/c1-64-44-31-27-42(28-32-44)57(41-20-11-6-12-21-41,43-29-33-45(65-2)34-30-43)67-38-49-52(53(66-3)55(68-49)60-37-35-51(59-56(60)63)58-54(62)40-18-9-5-10-19-40)70-71-61-36-17-26-48(61)50(69-71)39-72(4,46-22-13-7-14-23-46)47-24-15-8-16-25-47/h5-16,18-25,27-35,37,48-50,52-53,55H,17,26,36,38-39H2,1-4H3,(H,58,59,62,63)/t48-,49-,50+,52-,53-,55-,71+/m1/s1

DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-Phosphoramidite

Description: DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-Phosphoramidite is a reagent used in the synthesis of oligonucleotides.

CAT: BRP-02804

CAS: 1528733-90-5

Molecular Formula: C58H59N6O8PSi

Molecular Weight: 1027.20

Purity: ≥98%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: YPNIDBLCASOAIX-NEQFEEGOSA-N

SMILES: CO[C@H]1[C@H](N2C3=NC=NC(NC(C4=CC=CC=C4)=O)=C3N=C2)O[C@H](COC(C5=CC=C(OC)C=C5)(C6=CC=C(OC)C=C6)C7=CC=CC=C7)[C@H]1O[P@]8O[C@H](C[Si](C9=CC=CC=C9)(C)C%10=CC=CC=C%10)[C@@]%11([H])N8CCC%11