Phosphoramidites

(3R,5S)-5-([Bis(4-methoxyphenyl)(phenyl)methoxy]methyl)pyrrolidin-3-ol

Description: It is an L96-related intermediate used in drug delivery systems and biochemical research. The pyrrolidine core is a versatile scaffold for creating biologically active molecules, and the aromatic methoxyphenyl groups may contribute to interactions with hydrophobic pockets in biological targets. It is useful for designing compounds with specific stereochemical properties, potentially for enzyme inhibition or receptor targeting.

CAT: BRP-02451

CAS: 151953-64-9

Molecular Formula: C26H29NO4

Molecular Weight: 419.52

Purity: ≥97%

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Storage: Store at -20 °C

Density: 1.160±0.06 g/cm3

Boiling Point: 569.4±50.0 °C at 760 mmHg

InChIKey: CJFYBUJBXCVKLN-XZOQPEGZSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4C[C@H](CN4)O

IUPAC Name: (3R,5S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]pyrrolidin-3-ol

InChI: InChI=1S/C26H29NO4/c1-29-24-12-8-20(9-13-24)26(19-6-4-3-5-7-19,21-10-14-25(30-2)15-11-21)31-18-22-16-23(28)17-27-22/h3-15,22-23,27-28H,16-18H2,1-2H3/t22-,23+/m0/s1

Synonyms: 3-Pyrrolidinol, 5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-, (3R,5S)-; (3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-pyrrolidinol; 3-Pyrrolidinol, 5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-, (3R-trans)-

(R)-GNA-A(Bz) phosphoramidite

Description: (R)-GNA-A(Bz) phosphoramidite is a chemical compound used in the synthesis of Glycol Nucleic Acids (GNA). It contains an adenine (A) base with a benzoyl (Bz) protective group and is in the right-handed (R) stereoisomeric form. As a phosphoramidite, it serves as a building block for constructing GNA sequences, facilitating their synthesis in a manner similar to DNA or RNA. The benzoyl group protects the adenine during the process and can be removed afterward. This compound plays a key role in synthetic biology and molecular engineering, supporting applications in gene therapy, diagnostics, and nanotechnology.

CAT: BRP-02456

CAS: 182625-87-2

Molecular Formula: C45H50N7O6P

Molecular Weight: 815.90

Purity: ≥97%

Appearance: White or off-white solid

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Storage: Store at 2-8 °C

InChIKey: RHPZFMWWZNRHHT-FDEOUUESSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@H](CN1C=NC2=C(N=CN=C21)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[9-[(2R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]purin-6-yl]benzamide

InChI: InChI=1S/C45H50N7O6P/c1-32(2)52(33(3)4)59(57-27-13-26-46)58-40(28-51-31-49-41-42(47-30-48-43(41)51)50-44(53)34-14-9-7-10-15-34)29-56-45(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-25,30-33,40H,13,27-29H2,1-6H3,(H,47,48,50,53)/t40-,59?/m1/s1

Synonyms: (R)-G-A(Bz) phosphoramidite; N6-Bz-A-(R)-GNA phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (1R)-2-[6-(benzoylamino)-9H-purin-9-yl]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl ester; (1R)-2-[6-(Benzoylamino)-9H-purin-9-yl]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, (1R)-2-[6-(benzoylamino)-9H-purin-9-yl]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl ester; Phosphoramidous acid, bis(1-methylethyl)-, 2-[6-(benzoylamino)-9H-purin-9-yl]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl ester, (1R)-

(R)-GNA-G(iBu) phosphoramidite

Description: (R)-GNA-G(iBu) phosphoramidite is a chemical compound used in the synthesis of Glycol Nucleic Acids (GNA). It contains a guanine (G) base with an isobutyl (iBu) protective group and is in the right-handed (R) stereoisomeric form. As a phosphoramidite, (R)-GNA-G(iBu) is a key building block for the solid-phase synthesis of GNA strands, similar to how DNA and RNA are synthesized. This compound is important in areas such as synthetic biology, molecular engineering, and the development of GNA-based applications, including gene therapy, diagnostics, and nanotechnology.

CAT: BRP-02457

CAS: 182625-78-1

Molecular Formula: C42H52N7O7P

Molecular Weight: 797.89

Purity: ≥97%

Appearance: White or off-white solid

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Storage: Store at 2-8 °C

InChIKey: GOUPKQZMFOWLOW-COURYUFRSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C[C@H](COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C42H52N7O7P/c1-28(2)39(50)46-41-45-38-37(40(51)47-41)44-27-48(38)25-36(56-57(55-24-12-23-43)49(29(3)4)30(5)6)26-54-42(31-13-10-9-11-14-31,32-15-19-34(52-7)20-16-32)33-17-21-35(53-8)22-18-33/h9-11,13-22,27-30,36H,12,24-26H2,1-8H3,(H2,45,46,47,50,51)/t36-,57?/m1/s1

Synonyms: (R)-G-G(iBu)phosphoramidite; iBu-G-(S)-GNA phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (1R)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]methyl]ethyl 2-cyanoethyl ester; (1R)-2-[Bis(4-methoxyphenyl)phenylmethoxy]-1-[[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]methyl]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, (1R)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]methyl]ethyl 2-cyanoethyl ester

2'-Deoxy-2'-fluoro-N6-methyl-5'-O-DMTr-adenosine 3'-O-CE phosphoramidite

Description: 2'-Deoxy-2'-fluoro-N6-methyl-5'-O-DMTr-adenosine 3'-O-CE phosphoramidite is a phosphoramidite used in the synthesis of modified oligonucleotides. As a phosphoramidite, it serves as a key building block in the solid-phase synthesis of nucleic acid sequences. These modifications make it particularly useful for applications in gene therapy, diagnostics, and the creation of antisense oligonucleotides, where stability and specificity are crucial.

CAT: BRP-02458

CAS: 2803878-81-9

Molecular Formula: C41H49FN7O6P

Molecular Weight: 785.84

Purity: ≥95%

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Boiling Point: 828.6±75.0 °C at 760 mmHg

InChIKey: KEVCXRYRCXPTTF-CSBGXSTFSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC)=NC=N6)[C@H](F)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H49FN7O6P/c1-27(2)49(28(3)4)56(53-23-11-22-43)55-37-34(54-40(35(37)42)48-26-47-36-38(44-5)45-25-46-39(36)48)24-52-41(29-12-9-8-10-13-29,30-14-18-32(50-6)19-15-30)31-16-20-33(51-7)21-17-31/h8-10,12-21,25-28,34-35,37,40H,11,23-24H2,1-7H3,(H,44,45,46)/t34-,35-,37-,40-,56?/m1/s1

Synonyms: N6-Methyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite; 2'-Fluoro-dA(Me) CEP; 2'-Fluoro-Me-A-CEP; N6-Methyl-5'-O-DMT-2'-fluoro-2'-deoxyadenosine 3'-CE phosphoramidite; DMT-2'-F-dA(Me)-CE-Phosphoramidite; N6-Me-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-CE-Phosphoramidite; N6-Methyl-5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

5'-O-DMTr-2'-O-hexadecanyl 5-methyluridine 3'-CED phosphoramidite

Description: 5'-O-DMTr-2'-O-hexadecanyl 5-methyluridine 3'-CED phosphoramidite is a modified phosphoramidite used in the synthesis of oligonucleotides that require both hydrophobic modification (for membrane interaction or enhanced stability) and specific modifications to the sugar (for structural studies or functional applications). The CED and DMTr protecting groups make this suitable for automated solid-phase synthesis of such modified oligonucleotides. The 2'-O-hexadecanyl group in particular could be useful in creating modified RNA molecules with enhanced interactions with liposomes or other hydrophobic carriers, potentially for drug delivery, gene therapy, or studying membrane-associated processes.

CAT: BRP-02460

Molecular Formula: C56H81N4O9P

Molecular Weight: 985.26

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InChIKey: NTZLPKDKVDUPKR-YDSCUCAPSA-N

CanonicalSMILES: N#CCCOP(N(C(C)C)C(C)C)O[C@H]1[C@@H](OCCCCCCCCCCCCCCCC)[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1COC(C3=CC=C(OC)C=C3)(C4=CC=CC=C4)C5=CC=C(OC)C=C5

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(hexadecyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C56H81N4O9P/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-25-38-65-52-51(69-70(67-39-26-37-57)60(42(2)3)43(4)5)50(68-54(52)59-40-44(6)53(61)58-55(59)62)41-66-56(45-27-23-22-24-28-45,46-29-33-48(63-7)34-30-46)47-31-35-49(64-8)36-32-47/h22-24,27-36,40,42-43,50-52,54H,9-21,25-26,38-39,41H2,1-8H3,(H,58,61,62)/t50-,51-,52-,54-,70?/m1/s1

Synonyms: DMTr-2'-O-C16-5-Me-rU-3'-CE-Phosphoramidite; 2'-O-C16-5-Me-rU-3'-CE-Phosphoramidite; 2'-O-C16-5-Me-U phosphoramidite; 5-Methyluridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

N6-Bz-2'-deoxy-2'-fluoro-N6-methyl-5'-O-DMTr-adenosine 3'-O-CE phosphoramidite

Description: N6-Bz-2'-deoxy-2'-fluoro-N6-methyl-5'-O-DMTr-adenosine 3'-O-CE phosphoramidite is a phosphoramidite derivative that is specifically designed for the synthesis of modified DNA oligonucleotides. This compound is used to incorporate 2-fluoro modified nucleotides into oligonucleotides, improving metabolic stability. It plays a crucial role in DNA research by providing a means to create stable, modified DNA molecules that can be used to study DNA function and interactions with proteins. The modified adenosine enhances the binding affinity to DNA targets and improves the metabolic stability of the synthesized oligonucleotides, which is particularly important in the development of therapeutics and probes for gene expression regulation and gene silencing.

CAT: BRP-02461

CAS: 2659239-37-7

Molecular Formula: C48H53FN7O7P

Molecular Weight: 889.95

Purity: ≥95%

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InChIKey: UTNWUIGRRCGISW-ZDAUAZEPSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1F)N2C=NC3=C2N=CN=C3N(C)C(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]purin-6-yl]-N-methylbenzamide

InChI: InChI=1S/C48H53FN7O7P/c1-32(2)56(33(3)4)64(61-28-14-27-50)63-43-40(62-47(41(43)49)55-31-53-42-44(51-30-52-45(42)55)54(5)46(57)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(58-6)24-20-36)37-21-25-39(59-7)26-22-37/h8-13,15-26,30-33,40-41,43,47H,14,28-29H2,1-7H3/t40-,41-,43-,47-,64?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-(N-methylbenzamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; DMT-2'-F-N6-Me-dA(Bz) phosphoramidite; N6-Benzoyl-N6-Me-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite; N6-Benzoyl-N6-Me-5'-O-DMT-2'-fluoro-2'-deoxyadenosine 3'-CE phosphoramidite; DMT-2'-F-N6-Me-dA(Bz)-CE-Phosphoramidite; N6-Benzoyl-N6-methyl-5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

N4-Benzoyl-5'-O-DMTr-2'-O-TBDMS-N4-methylcytidine 3'-CED phosphoramidite

Description: N4-Benzoyl-5'-O-DMTr-2'-O-TBDMS-N4-methylcytidine 3'-CED phosphoramidite is a modified phosphoramidite designed for efficient and controlled synthesis of RNA oligonucleotides. It plays a crucial role in RNA research by providing a means to create stable, modified RNA molecules that can be used to study RNA function and interactions with proteins.

CAT: BRP-02464

Molecular Formula: C53H68N5O9PSi

Molecular Weight: 978.21

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InChIKey: NHBKCRSJHIQBKN-OHERSWKGSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=CC(N(C)C(C5=CC=CC=C5)=O)=N6)C6=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]4OP(OCCC#N)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-(N-methylbenzamido)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H68N5O9PSi/c1-37(2)58(38(3)4)68(64-35-19-33-54)66-47-45(36-63-53(40-22-17-14-18-23-40,41-24-28-43(61-9)29-25-41)42-26-30-44(62-10)31-27-42)65-50(48(47)67-69(11,12)52(5,6)7)57-34-32-46(55-51(57)60)56(8)49(59)39-20-15-13-16-21-39/h13-18,20-32,34,37-38,45,47-48,50H,19,35-36H2,1-12H3/t45-,47-,48-,50-,68?/m1/s1

Synonyms: 5'-O-DMT-2'-O-TBDMS-N4-Benzoyl-N4-Methy-Cytidine 3'-CE phosphoramidite; N4-Me-2'-O-TBDMS-rC(Bz) phosphoramidite; N4-Me-DMT-2'-O-TBDMS-C(Bz)-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N4-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

N4-Acetyl-5'-O-DMTr-N3-methyl-2'-O-TBDMS-cytidine 3'-CED phosphoramidite

Description: N4-Acetyl-5'-O-DMTr-N3-methyl-2'-O-TBDMS-cytidine 3'-CED phosphoramidite is a specific phosphoramidite compound used in the synthesis of modified oligonucleotides. This compound is designed to incorporate a modified cytidine nucleotide into RNA strands，which can enhance the stability and functionality of the synthesized oligonucleotides.

CAT: BRP-02465

Molecular Formula: C48H66N5O9PSi

Molecular Weight: 916.13

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Boiling Point: 830.8±75.0 °C at 760 mmHg

InChIKey: BFFAPJHDQZIRRE-HXZVCAGESA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@H](O4)[C@H]([C@H]([C@@H]4N5C=CC(N(C)C5=O)=NC(C)=O)O[Si](C)(C)C(C)(C)C)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-5-(4-(acetylimino)-3-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H66N5O9PSi/c1-33(2)53(34(3)4)63(59-31-17-29-49)61-43-41(60-45(44(43)62-64(12,13)47(6,7)8)52-30-28-42(50-35(5)54)51(9)46(52)55)32-58-48(36-18-15-14-16-19-36,37-20-24-39(56-10)25-21-37)38-22-26-40(57-11)27-23-38/h14-16,18-28,30,33-34,41,43-45H,17,31-32H2,1-13H3/t41-,43-,44-,45-,63?/m1/s1

Synonyms: N4-Acetyl-N3-methyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-tert-butyldimethylsilyl-N4-Acetyl-N3-methyl-cytidine 3'-CE phosphoramiditee; 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-N3-methyl-2'-O-t-butyldimethylsilylcytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMTr-N4-Ac-2'-O-TBDMS-N3-Me-cytidine-3'-CED Phosphoramidite; DMT-2'-O-TBDMS-N3-Me-rC(Ac) Phosphoramidite; 5'-DMT-2'-O-TBDMS-N4-Acetyl-N3-methylcytidine Phosphoramidite

Related CAS: 2931457-61-1 (N4-Acetyl-5'-O-DMTr-N3-methyl-2'-O-TBDMS-cytidine (S)-3'-CED phosphoramidite) ; 2931457-60-0 (N4-Acetyl-5'-O-DMTr-N3-methyl-2'-O-TBDMS-cytidine (R)-3'-CED phosphoramidite)

N4-Acetyl-5'-O-DMTr-N3-methyl-2'-O-TBDMS-cytidine (S)-3'-CED phosphoramidite

Description: N4-Acetyl-5'-O-DMTr-N3-methyl-2'-O-TBDMS-cytidine (S)-3'-CED phosphoramidite is a specific phosphoramidite compound used in the synthesis of modified oligonucleotides. This compound is designed to incorporate a modified cytidine nucleotide into RNA strands，which can enhance the stability and functionality of the synthesized oligonucleotides.

CAT: BRP-02466

CAS: 2931457-61-1

Molecular Formula: C48H66N5O9PSi

Molecular Weight: 916.13

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Boiling Point: 830.8±75.0 °C at 760 mmHg

InChIKey: BFFAPJHDQZIRRE-HQGXHSKWSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC(=O)C)N(C2=O)C)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

Synonyms: N4-Acetyl-N3-methyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-(S)-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-tert-butyldimethylsilyl-N4-Acetyl-N3-methyl-cytidine (S)-3'-CE phosphoramiditee; 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-N3-methyl-2'-O-t-butyldimethylsilylcytidine-(S)-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMTr-N4-Ac-2'-O-TBDMS-N3-Me-cytidine-(S)-3'-CED Phosphoramidite; DMT-2'-O-TBDMS-N3-Me-rC(Ac) (S)-Phosphoramidite; 5'-DMT-2'-O-TBDMS-N4-Acetyl-N3-methylcytidine (S)-Phosphoramidite

Related CAS: 2931457-60-0 (N4-Acetyl-5'-O-DMTr-N3-methyl-2'-O-TBDMS-cytidine (R)-3'-CED phosphoramidite)

N6-Benzoyl-5'-O-DMTr-3'-O-TBDMS-8-methyladenosine 2'-CED phosphoramidite

Description: N6-Benzoyl-5'-O-DMTr-3'-O-TBDMS-8-methyladenosine 2'-CED phosphoramidite is indeed a specialized phosphoramidite used in the synthesis of oligonucleotides, specifically for incorporating modified adenosine residues into RNA. This type of modification can enhance the stability of the oligonucleotides against nuclease degradation, potentially improving their utility in applications such as gene silencing, antisense therapy, and research into nucleic acid structure and function.

CAT: BRP-02467

CAS: 512172-15-5

Molecular Formula: C54H68N7O8PSi

Molecular Weight: 1002.22

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Boiling Point: 898.8±65.0 °C at 760 mmHg

InChIKey: JPUWQCBBWDRGBK-QRWWDSLFSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1O[Si](C)(C)C(C)(C)C)N5C=6N=CN=C(NC(=O)C=7C=CC=CC7)C6N=C5C)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-(6-benzamido-8-methyl-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H68N7O8PSi/c1-36(2)61(37(3)4)70(66-33-19-32-55)68-48-47(69-71(11,12)53(6,7)8)45(67-52(48)60-38(5)58-46-49(56-35-57-50(46)60)59-51(62)39-20-15-13-16-21-39)34-65-54(40-22-17-14-18-23-40,41-24-28-43(63-9)29-25-41)42-26-30-44(64-10)31-27-42/h13-18,20-31,35-37,45,47-48,52H,19,33-34H2,1-12H3,(H,56,57,59,62)/t45-,47-,48-,52-,70?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-8-methyl-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-3'-OTBS-8-Me-A(Bz) 2'-phosphoramidite; N6-Benzoyl-3'-OTBS-5'-O-DMT-8-methyladenosine 2'-CE phosphoramidite; N6-Benzoyl-5'-O-DMT-3'-O-TBDMS-8-methyladenosine 2'-CE phosphoramidite; DMT-3'-O-TBDMS-8-Me-A(Bz)-CE-Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-8-methyladenosine-2'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

N6-Benzoyl-5'-O-DMTr-2'-O-TBDMS-8-methyladenosine 3'-CED phosphoramidite

Description: N6-Benzoyl-5'-O-DMTr-2'-O-TBDMS-8-methyladenosine 3'-CED phosphoramidite is a specialized phosphoramidite compound used in the synthesis of oligonucleotides. This compound is designed to incorporate a specific modification into RNA strands, which can enhance the stability and functionality of the synthesized oligonucleotides.

CAT: BRP-02468

Molecular Formula: C54H68N7O8PSi

Molecular Weight: 1002.22

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Boiling Point: 898.8±65.0 °C at 760 mmHg

InChIKey: VXHCGBIVLNKEGI-QRWWDSLFSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C(C)=N5)C6=C5C(NC(C7=CC=CC=C7)=O)=NC=N6)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-8-methyl-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H68N7O8PSi/c1-36(2)61(37(3)4)70(66-33-19-32-55)68-47-45(34-65-54(40-22-17-14-18-23-40,41-24-28-43(63-9)29-25-41)42-26-30-44(64-10)31-27-42)67-52(48(47)69-71(11,12)53(6,7)8)60-38(5)58-46-49(56-35-57-50(46)60)59-51(62)39-20-15-13-16-21-39/h13-18,20-31,35-37,45,47-48,52H,19,33-34H2,1-12H3,(H,56,57,59,62)/t45-,47-,48-,52-,70?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-8-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-2'-OTBS-8-Me-A(Bz) phosphoramidite; N6-Benzoyl-2'-OTBS-5'-O-DMT-8-methyladenosine 3'-CE phosphoramidite; N6-Benzoyl-5'-O-DMT-2'-O-TBDMS-8-methyladenosine 3'-CE phosphoramidite; DMT-2'-O-TBDMS-8-Me-A(Bz)-CE-Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-8-methyladenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

N6-Benzoyl-5'-O-DMTr-2'-O-TBDMS-2-methyladenosine 3'-CED phosphoramidite

Description: N6-Benzoyl-5'-O-DMTr-2'-O-TBDMS-2-methyladenosine 3'-CED phosphoramidite is a specialized phosphoramidite compound used in the synthesis of oligonucleotides. This compound is designed to incorporate a specific modification into RNA strands, which can enhance the stability and functionality of the synthesized oligonucleotides.

CAT: BRP-02469

CAS: 163496-25-1

Molecular Formula: C54H68N7O8PSi

Molecular Weight: 1002.22

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InChIKey: AGBHTIRZTGVRNB-QRWWDSLFSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(C7=CC=CC=C7)=O)=NC(C)=N6)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-2-methyl-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H68N7O8PSi/c1-36(2)61(37(3)4)70(66-33-19-32-55)68-47-45(34-65-54(40-22-17-14-18-23-40,41-24-28-43(63-9)29-25-41)42-26-30-44(64-10)31-27-42)67-52(48(47)69-71(11,12)53(6,7)8)60-35-56-46-49(57-38(5)58-50(46)60)59-51(62)39-20-15-13-16-21-39/h13-18,20-31,35-37,45,47-48,52H,19,33-34H2,1-12H3,(H,57,58,59,62)/t45-,47-,48-,52-,70?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-2-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-2-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; DMT-2'-OTBS-2-Me-A(Bz) phosphoramidite; N6-Benzoyl-2'-OTBS-5'-O-DMT-2-methyladenosine 3'-CE phosphoramidite; N6-Benzoyl-5'-O-DMT-2'-O-TBDMS-2-methyladenosine 3'-CE phosphoramidite; DMT-2'-O-TBDMS-2-Me-A(Bz)-CE-Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-2-methyladenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

N2,N2-Dimethyl-5'-O-DMTr-2'-O-TBDMS guanosine 3'-CED phosphoramidite

Description: N2,N2-Dimethyl-5'-O-DMTr-2'-O-TBDMS-guanosine 3'-CED phosphoramidite is a phosphoramidite compound used in RNA synthesis. It is derived from the nucleoside guanosine, with various protective groups attached to key functional sites. These protective groups prevent unwanted reactions during the solid-phase synthesis process, ensuring selective reactivity at each position. This compound serves as a building block for assembling nucleic acid sequences in automated synthesis.

CAT: BRP-02470

Molecular Formula: C48H66N7O8PSi

Molecular Weight: 928.16

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InChIKey: AUHAFQHYACPHSD-LKYMEUIMSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N(C)C)=N6)=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(dimethylamino)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H66N7O8PSi/c1-32(2)55(33(3)4)64(60-29-17-28-49)62-41-39(61-45(42(41)63-65(12,13)47(5,6)7)54-31-50-40-43(54)51-46(53(8)9)52-44(40)56)30-59-48(34-18-15-14-16-19-34,35-20-24-37(57-10)25-21-35)36-22-26-38(58-11)27-23-36/h14-16,18-27,31-33,39,41-42,45H,17,29-30H2,1-13H3,(H,51,52,56)/t39-,41-,42-,45-,64?/m1/s1

Synonyms: 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N2,N2-dimethylguanosine 3'-CE phosphoramidite; 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N2,N2-dimethylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; DMT-2'-O-TBDMS-rG(N2,N2-dimethyl) Phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-N2,N2-dimethylguanosine; 5'-O-DMT-2'-O-TBDMS-N2,N2-dimethyl-Guanosine-CE Phosphoramidite; DMT-2'-O-TBDMS-G(di-Me)-CE-Phosphoramidite; N2,N2-Dimethyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

N2,N2-Dimethyl-5'-O-DMTr-2'-O-TOM guanosine 3'-CED phosphoramidite

Description: N2,N2-Dimethyl-5'-O-DMTr-2'-O-TOM-guanosine 3'-CED phosphoramidite is a modified phosphoramidite derivative used in RNA synthesis. This compound is designed for use in automated solid-phase oligonucleotide synthesis, where it allows the sequential addition of guanosine units into a growing RNA strand while protecting key functional groups to ensure controlled reactions and high purity.

CAT: BRP-02471

CAS: 872548-62-4

Molecular Formula: C52H74N7O9PSi

Molecular Weight: 1000.25

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Boiling Point: 920.6±75.0 °C at 760 mmHg

InChIKey: OLHWVXMEBXXTRD-HIOQIZMDSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC32)N(C)C)C1OCO[Si](C(C)C)(C(C)C)C(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(dimethylamino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H74N7O9PSi/c1-34(2)59(35(3)4)69(65-30-18-29-53)68-46-44(31-64-52(39-19-16-15-17-20-39,40-21-25-42(61-13)26-22-40)41-23-27-43(62-14)28-24-41)67-50(47(46)63-33-66-70(36(5)6,37(7)8)38(9)10)58-32-54-45-48(58)55-51(57(11)12)56-49(45)60/h15-17,19-28,32,34-38,44,46-47,50H,18,30-31,33H2,1-14H3,(H,55,56,60)/t44-,46-,47-,50-,69?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N,N-dimethyl-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMT-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-N2,N2-dimethylguanosine 3'-CE phosphoramidite; 5'-O-(4,4-Dimethoxytrityl)-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-N2,N2-dimethylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; DMT-2'-O-TOM-rG(N2,N2-dimethyl) Phosphoramidite; 5'-O-DMT-2'-O-TOM-N2,N2-dimethyl-Guanosine-CE Phosphoramidite; DMT-2'-O-TOM-G(di-Me)-CE-Phosphoramidite; N2,N2-Dimethyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-guanosine-3'-cyanoethyl Phosphoramidite

N2-Methyl-5'-O-DMTr-2'-O-TBDMS guanosine 3'-CED phosphoramidite

Description: N2-Methyl-5'-O-DMTr-2'-O-TBDMS guanosine 3'-CED phosphoramidite is a phosphoramidite compound used in RNA synthesis. It is derived from the nucleoside guanosine, with various protective groups attached to key functional sites. These protective groups prevent unwanted reactions during the solid-phase synthesis process, ensuring selective reactivity at each position. This compound serves as a building block for assembling nucleic acid sequences in automated synthesis.

CAT: BRP-02472

Molecular Formula: C47H64N7O8PSi

Molecular Weight: 914.13

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InChIKey: RNYXUWAQJPNBRD-SLLDXECHSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(NC)=N6)=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(methylamino)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H64N7O8PSi/c1-31(2)54(32(3)4)63(59-28-16-27-48)61-40-38(60-44(41(40)62-64(11,12)46(5,6)7)53-30-50-39-42(53)51-45(49-8)52-43(39)55)29-58-47(33-17-14-13-15-18-33,34-19-23-36(56-9)24-20-34)35-21-25-37(57-10)26-22-35/h13-15,17-26,30-32,38,40-41,44H,16,28-29H2,1-12H3,(H2,49,51,52,55)/t38-,40-,41-,44-,63?/m1/s1

Synonyms: 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N2-methylguanosine 3'-CE phosphoramidite; 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N2-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; DMT-2'-O-TBDMS-rG(Me) Phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-N2-methylguanosine; 5'-O-DMT-2'-O-TBDMS-N2-methyl-Guanosine-CE Phosphoramidite; DMT-2'-O-TBDMS-G(Me)-CE-Phosphoramidite; N2-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

N4-Acetyl-5-acetyloxymethyl-5'-O-DMTr-2'-O-TBDMS cytidine 3'-CED phosphoramidite

Description: N4-Acetyl-5-acetyloxymethyl-5'-O-DMTr-2'-O-TBDMS-cytidine 3'-CED phosphoramidite is a modified phosphoramidite compound used in the synthesis of RNA. This compound is used in the solid-phase synthesis of RNA sequences, where the protective groups ensure selective reactivity and prevent undesired reactions, allowing for the controlled assembly of oligonucleotides. The phosphoramidite functionality enables efficient coupling during automated nucleotide synthesis.

CAT: BRP-02473

CAS: 1887094-84-9

Molecular Formula: C50H68N5O11PSi

Molecular Weight: 974.16

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InChIKey: DZAHXQMAVOPUPG-HEUILFTOSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)N2C=C(C(=NC2=O)NC(=O)C)COC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: [4-acetamido-1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-5-yl]methyl acetate

InChI: InChI=1S/C50H68N5O11PSi/c1-33(2)55(34(3)4)67(63-29-17-28-51)65-44-43(32-62-50(38-18-15-14-16-19-38,39-20-24-41(59-10)25-21-39)40-22-26-42(60-11)27-23-40)64-47(45(44)66-68(12,13)49(7,8)9)54-30-37(31-61-36(6)57)46(52-35(5)56)53-48(54)58/h14-16,18-27,30,33-34,43-45,47H,17,29,31-32H2,1-13H3,(H,52,53,56,58)/t43-,44-,45-,47-,67?/m1/s1

Synonyms: Cytidine, N-acetyl-5-[(acetyloxy)methyl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N4-Acetyl-5-acetyloxymethyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-tert-butyldimethylsilyl-N4-Acetyl-5-acetyloxymethyl-cytidine 3'-CE phosphoramiditee; 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-5-acetyloxymethyl-2'-O-t-butyldimethylsilylcytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMTr-N4-Ac-2'-O-TBDMS-5-CH2-OAc-cytidine-3'-CED Phosphoramidite; DMT-2'-O-TBDMS-5-CH2-OAc-rC(Ac) Phosphoramidite; 5'-DMT-2'-O-TBDMS-N4-Acetyl-5-acetyloxymethylcytidine Phosphoramidite

5'-O-DMTr-2'-O-ethyl-5-methyluridine-3'-CE-phosphoramidite

Description: 5'-O-DMTr-2'-O-ethyl-5-methyluridine-3'-CE-phosphoramidite is a modified phosphoramidite compound used in oligonucleotides synthesis. This compound is primarily used in the solid-phase synthesis of RNA, where the protecting groups ensure that selective reactions occur at the desired sites. The phosphoramidite functionality facilitates the stepwise addition of nucleotides during automated oligonucleotide synthesis, allowing for the controlled assembly of RNA sequences.

CAT: BRP-02474

Molecular Formula: C42H53N4O9P

Molecular Weight: 788.88

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InChIKey: JBJTXWYTJVUVJC-WDABSCDASA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@H](O4)[C@H]([C@H]([C@@H]4N5C=C(C)C(NC5=O)=O)OCC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-ethoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H53N4O9P/c1-9-51-38-37(55-56(53-25-13-24-43)46(28(2)3)29(4)5)36(54-40(38)45-26-30(6)39(47)44-41(45)48)27-52-42(31-14-11-10-12-15-31,32-16-20-34(49-7)21-17-32)33-18-22-35(50-8)23-19-33/h10-12,14-23,26,28-29,36-38,40H,9,13,25,27H2,1-8H3,(H,44,47,48)/t36-,37-,38-,40-,56?/m1/s1

Synonyms: 5'-O-DMT-2'-O-ethyl-5-methyluridine 3'-CE phosphoramidite; 5'-O-DMT-5-ethyl-2'-O-methyluridine 3'-CE phosphoramidite; 5'-O-DMT-2'-O-ethyl-5-methyl-D-uridine 3'-CE phosphoramidite; 2'-O-Ethyl-5-methyl-U CEP; 5-O-(4,4'-Dimethoxytrityl)-3-O-(diisopropylamino-2-cyanoethoxyphosphanyl)-1-deoxy-2-O-ethyl-1-thymin-1-yl-beta-D-ribo-pentofuranose; 5-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-ethyl-uridine-3'-cyanoethyl phosphoramidite

1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N2-isobutyroylguanine

Description: 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N2-isobutyroylguanine is a modified phosphoramidite compound used in oligonucleotides synthesis. This compound is primarily used in the solid-phase synthesis of RNA, where the protecting groups ensure that selective reactions occur at the desired sites. The phosphoramidite functionality facilitates the stepwise addition of nucleotides during automated oligonucleotide synthesis, allowing for the controlled assembly of RNA sequences.

CAT: BRP-02475

Molecular Formula: C29H47N7O9P2

Molecular Weight: 699.68

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Storage: Store at -20 °C

InChIKey: BLZYIQYIBDZHTR-GXTDANTHSA-N

CanonicalSMILES: CO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCC)(OCC)=O)O[C@H]1N2C(N=C(NC(C(C)C)=O)NC3=O)=C3N=C2

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-2-((E)-2-(diethoxyphosphoryl)vinyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C29H47N7O9P2/c1-10-42-47(39,43-11-2)16-13-21-23(45-46(41-15-12-14-30)36(19(5)6)20(7)8)24(40-9)28(44-21)35-17-31-22-25(35)32-29(34-27(22)38)33-26(37)18(3)4/h13,16-21,23-24,28H,10-12,15H2,1-9H3,(H2,32,33,34,37,38)/b16-13+/t21-,23-,24-,28-,46?/m1/s1

Synonyms: 5'-Et-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylmino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(dimethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N2-isobutyroylguanine

1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-MOE)-β-D-ribo-hex-5-enofuranosyl]uracil

Description: 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-MOE)-β-D-ribo-hex-5-enofuranosyl]uracil is a modified phosphoramidite compound used in oligonucleotides synthesis. This compound is primarily used in the solid-phase synthesis of RNA, where the protecting groups ensure that selective reactions occur at the desired sites. The phosphoramidite functionality facilitates the stepwise addition of nucleotides during automated oligonucleotide synthesis, allowing for the controlled assembly of RNA sequences.

CAT: BRP-02476

Molecular Formula: C26H44N4O10P2

Molecular Weight: 634.60

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Storage: Store at -20 °C

InChIKey: ZYDXGMNXIGPASP-PEZPBANCSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H](OCCOC)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1/C=C/P(OCC)(OCC)=O

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-2-((E)-2-(diethoxyphosphoryl)vinyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C26H44N4O10P2/c1-8-37-42(33,38-9-2)18-12-21-23(40-41(36-15-10-13-27)30(19(3)4)20(5)6)24(35-17-16-34-7)25(39-21)29-14-11-22(31)28-26(29)32/h11-12,14,18-21,23-25H,8-10,15-17H2,1-7H3,(H,28,31,32)/b18-12+/t21-,23-,24-,25-,41?/m1/s1

Synonyms: 5'-Et-(E)-vinyl phosphonate-2'-O-MOE-rU-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-MOE-rU-3'-CE-Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-β-D-ribo-hex-5-enofuranosyl]uracil

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-C(Ac)-3'-CE-Phosphoramidite

Description: 5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-C(Ac)-3'-CE-Phosphoramidite is a highly modified cytidine phosphoramidite used in oligonucleotide synthesis. The 5'-O-DMTr (dimethoxytrityl) group serves as a protective group for the 5' hydroxyl during stepwise synthesis. The 2'-O-trifluoroacetamindo propyl modification adds a trifluoroacetamido group linked via a propyl spacer to the 2'-hydroxyl of the ribose, enhancing hydrophobicity and potentially altering enzymatic interactions or duplex stability. The C(Ac) designation indicates that the cytosine base is protected by an acetyl group at the N4 position, ensuring stability during synthesis. The 3'-CE phosphoramidite (cyanoethyl) group enables the coupling of this nucleotide into a growing oligonucleotide chain via phosphoramidite chemistry. This compound is often employed in the synthesis of modified oligonucleotides for research or therapeutic purposes, where specific modifications are required for stability, resistance to degradation, or unique biological functionality.

CAT: BRP-02480

Molecular Formula: C46H56F3N6O10P

Molecular Weight: 940.95

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InChIKey: CVNXSPGCWPGLBY-CHKGVOQCSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N5C(N=C(NC(C)=O)C=C5)=O)[C@H](OCCCNC(C(F)(F)F)=O)[C@@H]4OP(OCCC#N)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(3-(2,2,2-trifluoroacetamido)propoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H56F3N6O10P/c1-30(2)55(31(3)4)66(63-28-11-24-50)65-40-38(64-42(54-26-23-39(52-32(5)56)53-44(54)58)41(40)61-27-12-25-51-43(57)46(47,48)49)29-62-45(33-13-9-8-10-14-33,34-15-19-36(59-6)20-16-34)35-17-21-37(60-7)22-18-35/h8-10,13-23,26,30-31,38,40-42H,11-12,25,27-29H2,1-7H3,(H,51,57)(H,52,53,56,58)/t38-,40-,41-,42-,66?/m1/s1

Synonyms: N4-Acetyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; N4-Acetyl-5'-O-DMTr-2'-O-(N3-trifluoroacetyl)cytidine 3'-CE-Phosphoramidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[3-[(trifluoroacetyl)amino]propyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; N4-Acetyl-2'-O-trifluoroacetamido propyl Cytidine CED phosphoramidite

(3R,5S)-5-([Bis(4-methoxyphenyl)(phenyl)methoxy]methyl)pyrrolidin-3-ol

(R)-GNA-A(Bz) phosphoramidite

(R)-GNA-G(iBu) phosphoramidite

2'-Deoxy-2'-fluoro-N6-methyl-5'-O-DMTr-adenosine 3'-O-CE phosphoramidite

5'-O-DMTr-2'-O-hexadecanyl 5-methyluridine 3'-CED phosphoramidite

N6-Bz-2'-deoxy-2'-fluoro-N6-methyl-5'-O-DMTr-adenosine 3'-O-CE phosphoramidite

N4-Benzoyl-5'-O-DMTr-2'-O-TBDMS-N4-methylcytidine 3'-CED phosphoramidite

N4-Acetyl-5'-O-DMTr-N3-methyl-2'-O-TBDMS-cytidine 3'-CED phosphoramidite

N4-Acetyl-5'-O-DMTr-N3-methyl-2'-O-TBDMS-cytidine (S)-3'-CED phosphoramidite

N6-Benzoyl-5'-O-DMTr-3'-O-TBDMS-8-methyladenosine 2'-CED phosphoramidite

N6-Benzoyl-5'-O-DMTr-2'-O-TBDMS-8-methyladenosine 3'-CED phosphoramidite

N6-Benzoyl-5'-O-DMTr-2'-O-TBDMS-2-methyladenosine 3'-CED phosphoramidite

N2,N2-Dimethyl-5'-O-DMTr-2'-O-TBDMS guanosine 3'-CED phosphoramidite

N2,N2-Dimethyl-5'-O-DMTr-2'-O-TOM guanosine 3'-CED phosphoramidite

N2-Methyl-5'-O-DMTr-2'-O-TBDMS guanosine 3'-CED phosphoramidite

N4-Acetyl-5-acetyloxymethyl-5'-O-DMTr-2'-O-TBDMS cytidine 3'-CED phosphoramidite

5'-O-DMTr-2'-O-ethyl-5-methyluridine-3'-CE-phosphoramidite

1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N2-isobutyroylguanine

1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-MOE)-β-D-ribo-hex-5-enofuranosyl]uracil

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-C(Ac)-3'-CE-Phosphoramidite

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