Phosphoramidites

2'-Modified Phosphoramidites
(549/549) 2'-Phosphoramidites
(27/27) 3'-Modified Phosphoramidites
(201/201) 5'-Modified Phosphoramidites
(34/34) Arabino Phosphoramidites
(24/24) Base Protected Phosphoramidites (435/435) Dye Phosphoramidites
(64/64) Label Phosphoramidites
(81/81) Linker Phosphoramidites
(97/97) Other Phosphoramidites
(94/94) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(25/25) Spacer Phosphoramidites
(24/24)

DMTr-2'-O-C16-rG(DMF)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-rG(DMF)-3'-CE-Phosphoramidite is a phosphoramidite in which guanosine is protected at the N2 position with a dimethylformamidine (DMF) group, the 5'-hydroxyl with a dimethoxytrityl (DMTr) group, the 3'-position with a cyanoethyl (CE) phosphoramidite, and the 2'-hydroxyl is modified with a hexadecyl (C16) long-chain substituent. It is applied in solid-phase RNA synthesis to introduce hydrophobic C16 lipid-like modifications, which improve membrane interaction, cellular uptake, and in vivo stability of oligonucleotides for therapeutic delivery.

CAT: BRP-02719

Molecular Formula: C59H85N8O8P

Molecular Weight: 1065.35

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InChIKey: REQILBSOGLPEGS-UVFXKDKVSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N=CN(C)C)=N6)=O)[C@H](OCCCCCCCCCCCCCCCC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C59H85N8O8P/c1-10-11-12-13-14-15-16-17-18-19-20-21-22-26-39-71-54-53(75-76(73-40-27-38-60)67(44(2)3)45(4)5)51(74-57(54)66-43-61-52-55(66)63-58(64-56(52)68)62-42-65(6)7)41-72-59(46-28-24-23-25-29-46,47-30-34-49(69-8)35-31-47)48-32-36-50(70-9)37-33-48/h23-25,28-37,42-45,51,53-54,57H,10-22,26-27,39-41H2,1-9H3,(H,63,64,68)/t51-,53-,54-,57-,76?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(hexadecyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; N2-DMF-5'-O-DMTr-2'-O-hexadecanyl guanosine 3'-CED phosphoramidite; 2'-O-C16-G(DMF) phosphoramidite

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BOC Sciences is a leading provider of DNA and RNA products and services that meet the needs of researchers and pharmaceutical companies worldwide. Its broad product portfolio includes various types of oligonucleotides, DNA/RNA synthesis feedstocks, RNA interference tools, and advanced drug delivery systems, among others. Designed to promote cutting-edge research and innovative therapeutic solutions, at BOC Sciences you are sure to find the right product for you.

DMTr-2'-O-C16-rG(DMF)-3'-CE-Phosphoramidite

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