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Phosphoramidites

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2'-Modified Phosphoramidites
(594/594) 2'-Phosphoramidites
(27/27) 3'-Modified Phosphoramidites
(246/246) 5'-Modified Phosphoramidites
(79/79) Arabino Phosphoramidites
(24/24) Base Protected Phosphoramidites (469/469) Dye Phosphoramidites
(63/63) Label Phosphoramidites
(81/81) Linker Phosphoramidites
(97/97) Other Phosphoramidites
(94/94) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(25/25) Spacer Phosphoramidites
(24/24)
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DMTr-2'-F-dG(iBu)-3'-PS2-Amidite

Description: DMTr-2'-F-dG(iBu)-3'-PS2-Amidite is a reagent used in the synthesis of oligonucleotides.
CAT: BRP-02838
Molecular Formula: C48H52FN6O8PS2
Molecular Weight: 955.07
Purity: ≥98%
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Storage: Store at -20 °C
InChIKey: GOLSECBBKDTIRM-IMYAOLGDSA-N
CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N7CCCC7)SCCSC(=O)C8=CC=CC=C8)F
IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate
InChI: InChI=1S/C48H52FN6O8PS2/c1-31(2)43(56)52-47-51-42-40(44(57)53-47)50-30-55(42)45-39(49)41(63-64(54-25-11-12-26-54)66-28-27-65-46(58)32-13-7-5-8-14-32)38(62-45)29-61-48(33-15-9-6-10-16-33,34-17-21-36(59-3)22-18-34)35-19-23-37(60-4)24-20-35/h5-10,13-24,30-31,38-39,41,45H,11-12,25-29H2,1-4H3,(H2,51,52,53,56,57)/t38-,39-,41-,45-,64?/m1/s1
Synonyms: DMTr-2'-F-dG(iBu)-3'-Thiophosphoramidite

DMTr-2'-F-dC(Ac)-3'-PS2-Amidite

Description: DMTr-2'-F-dC(Ac)-3'-PS2-Amidite is a reagent used in the synthesis of oligonucleotides.
CAT: BRP-02839
Molecular Formula: C45H48FN4O8PS2
Molecular Weight: 886.99
Purity: ≥98%
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Storage: Store at -20 °C
InChIKey: YEUOGNRGLBQTSU-ZMHKPELYSA-N
CanonicalSMILES: COC1=CC=C(C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N5CCCC5)SCCSC(C6=CC=CC=C6)=O)[C@@H](F)[C@H](N7C(N=C(NC(C)=O)C=C7)=O)O4)C=C1
InChI: InChI=1S/C45H48FN4O8PS2/c1-31(51)47-39-24-27-50(44(53)48-39)42-40(46)41(58-59(49-25-10-11-26-49)61-29-28-60-43(52)32-12-6-4-7-13-32)38(57-42)30-56-45(33-14-8-5-9-15-33,34-16-20-36(54-2)21-17-34)35-18-22-37(55-3)23-19-35/h4-9,12-24,27,38,40-42H,10-11,25-26,28-30H2,1-3H3,(H,47,48,51,53)/t38-,40-,41-,42-,59?/m1/s1
Synonyms: DMTr-2'-F-dC(Ac)-3'-Thiophosphoramidite

DMTr-2'-F-dU-3'-PS2-Amidite

Description: DMTr-2'-F-dU-3'-PS2-Amidite is a reagent used in the synthesis of oligonucleotides.
CAT: BRP-02840
Molecular Formula: C43H45FN3O8PS2
Molecular Weight: 845.94
Purity: ≥98%
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Storage: Store at -20 °C
InChIKey: HUXZGSPNSAYIPS-CYSIDSPMSA-N
CanonicalSMILES: COC1=CC=C(C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N5CCCC5)SCCSC(C6=CC=CC=C6)=O)[C@@H](F)[C@H](N7C(NC(C=C7)=O)=O)O4)C=C1
InChI: InChI=1S/C43H45FN3O8PS2/c1-51-34-19-15-32(16-20-34)43(31-13-7-4-8-14-31,33-17-21-35(52-2)22-18-33)53-29-36-39(38(44)40(54-36)47-26-23-37(48)45-42(47)50)55-56(46-24-9-10-25-46)58-28-27-57-41(49)30-11-5-3-6-12-30/h3-8,11-23,26,36,38-40H,9-10,24-25,27-29H2,1-2H3,(H,45,48,50)/t36-,38-,39-,40-,56?/m1/s1
Synonyms: DMTr-2'-F-dU-3'-Thiophosphoramidite

DMTr-2'-O-C6-rA(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C6-rA(Bz)-3'-CE-Phosphoramidite is a reagent used in the synthesis of oligonucleotides.
CAT: BRP-02841
CAS: 2642321-66-0
Molecular Formula: C53H64N7O8P
Molecular Weight: 958.09
Purity: ≥98%
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Storage: Store at -20 °C
InChIKey: QGOPOAHCJYOCNH-RESYHYSISA-N
CanonicalSMILES: CCCCCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-hexoxyoxolan-2-yl]purin-6-yl]benzamide
InChI: InChI=1S/C53H64N7O8P/c1-8-9-10-17-32-64-48-47(68-69(66-33-18-31-54)60(37(2)3)38(4)5)45(67-52(48)59-36-57-46-49(55-35-56-50(46)59)58-51(61)39-19-13-11-14-20-39)34-65-53(40-21-15-12-16-22-40,41-23-27-43(62-6)28-24-41)42-25-29-44(63-7)30-26-42/h11-16,19-30,35-38,45,47-48,52H,8-10,17-18,32-34H2,1-7H3,(H,55,56,58,61)/t45-,47-,48-,52-,69?/m1/s1
Synonyms: 2'-O-hexyl A(Bz) amidite

DMTr-2'-O-C6-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C6-rC(Bz)-3'-CE-Phosphoramidite is a reagent used in the synthesis of oligonucleotides.
CAT: BRP-02842
CAS: 2642321-61-5
Molecular Formula: C52H64N5O9P
Molecular Weight: 934.07
Purity: ≥98%
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Storage: Store at -20 °C
InChIKey: RFWDWXMWINZAJF-NOJOPTKUSA-N
CanonicalSMILES: CCCCCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-hexoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C52H64N5O9P/c1-8-9-10-17-34-62-48-47(66-67(64-35-18-32-53)57(37(2)3)38(4)5)45(65-50(48)56-33-31-46(55-51(56)59)54-49(58)39-19-13-11-14-20-39)36-63-52(40-21-15-12-16-22-40,41-23-27-43(60-6)28-24-41)42-25-29-44(61-7)30-26-42/h11-16,19-31,33,37-38,45,47-48,50H,8-10,17-18,34-36H2,1-7H3,(H,54,55,58,59)/t45-,47-,48-,50-,67?/m1/s1
Synonyms: 2'-O-hexyl C(Bz) amidite

DMTr-2'-O-C6-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C6-rG(iBu)-3'-CE-Phosphoramidite is a reagent used in the synthesis of oligonucleotides.
CAT: BRP-02843
CAS: 2642321-69-3
Molecular Formula: C50H66N7O9P
Molecular Weight: 940.07
Purity: ≥98%
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Storage: Store at -20 °C
InChIKey: ZVDISOOZPNLAHG-IBSROIRUSA-N
CanonicalSMILES: CCCCCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)NC(=O)C(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-hexoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
InChI: InChI=1S/C50H66N7O9P/c1-10-11-12-16-29-62-44-43(66-67(64-30-17-28-51)57(34(4)5)35(6)7)41(65-48(44)56-32-52-42-45(56)53-49(55-47(42)59)54-46(58)33(2)3)31-63-50(36-18-14-13-15-19-36,37-20-24-39(60-8)25-21-37)38-22-26-40(61-9)27-23-38/h13-15,18-27,32-35,41,43-44,48H,10-12,16-17,29-31H2,1-9H3,(H2,53,54,55,58,59)/t41-,43-,44-,48-,67?/m1/s1
Synonyms: 2'-O-hexyl G(iBu) amidite

Frequently Asked Questions (FAQ)

What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

* Only for research. Not suitable for any diagnostic or therapeutic use.

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