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Phosphoramidites

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2'-Modified Phosphoramidites
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FAM phosphoramidite, 6-isomer (hydroxyprolinol) (BRP-02845)

FAM phosphoramidite, 6-isomer (hydroxyprolinol)

Description: FAM phosphoramidite, 6-isomer (hydroxyprolinol) is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 6-carboxyfluorescein (6-FAM) fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety, enabling the incorporation of a fluorescent label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold that may offer improved photophysical properties or reduced quenching compared to standard linkers. It is used in molecular biology applications including DNA sequencing, PCR fragment analysis, genotyping, and fluorescence resonance energy transfer (FRET) studies.
CAT: BRP-02845
CAS: 959470-55-4
Molecular Formula: C72H83N4O14P
Molecular Weight: 1259.44
Purity: ≥95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: ZDVYQZZZQOKACR-YQZMZASNSA-N
Solubility: Soluble in DMSO
SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1C[C@H](N(C1)C(=O)CCCCCNC(=O)C2=CC3=C(C=C2)C(=O)OC34C5=C(C=C(C=C5)OC(=O)C(C)(C)C)OC6=C4C=CC(=C6)OC(=O)C(C)(C)C)COC(C7=CC=CC=C7)(C8=CC=C(C=C8)OC)C9=CC=C(C=C9)OC
IUPAC Name: [6-[[6-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypyrrolidin-1-yl]-6-oxohexyl]carbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate
InChI: InChI=1S/C72H83N4O14P/c1-46(2)76(47(3)4)91(85-39-19-37-73)90-57-41-52(45-84-71(49-20-15-13-16-21-49,50-24-28-53(82-11)29-25-50)51-26-30-54(83-12)31-27-51)75(44-57)64(77)22-17-14-18-38-74-65(78)48-23-34-58-61(40-48)72(89-66(58)79)59-35-32-55(86-67(80)69(5,6)7)42-62(59)88-63-43-56(33-36-60(63)72)87-68(81)70(8,9)10/h13,15-16,20-21,23-36,40,42-43,46-47,52,57H,14,17-19,22,38-39,41,44-45H2,1-12H3,(H,74,78)/t52-,57+,91?/m0/s1
Synonyms: 6-FAM Pro Phosphoramidite; 6-FAM Phosphoramidite (hydroxyprolinol); 6-Fluorescein phosphoramidite (hydroxyprolinol); 6-Carboxyfluorescein phosphoramidite (hydroxyprolinol); 6-((6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)
5-JOE Phosphoramidite, CHC protected (BRP-02846)

5-JOE Phosphoramidite, CHC protected

Description: 5-JOE Phosphoramidite, CHC protected is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 5-carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein (5-JOE) fluorophore with a cyclohexylcarbonyl (CHC) protecting group on the phenolic hydroxyl groups of the JOE dye. The CHC protection enhances stability during synthesis and deprotection steps. It enables incorporation of the JOE label at the 5' end of DNA sequences during automated solid-phase synthesis, and is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02846
CAS: 1353002-88-6
Molecular Formula: C52H64Cl2N3O12P
Molecular Weight: 1024.97
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InChIKey: URRZVDVFVFCJFI-UHFFFAOYSA-N
SMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC2=C(C=C1)C3(C4=CC(=C(C(=C4OC5=C(C(=C(C=C53)OC)OC(=O)C6CCCCC6)Cl)Cl)OC(=O)C7CCCCC7)OC)OC2=O)OCCC#N
IUPAC Name: [4',5'-dichloro-5-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(cyclohexanecarbonyloxy)-2',7'-dimethoxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] cyclohexanecarboxylate
InChI: InChI=1S/C52H64Cl2N3O12P/c1-31(2)57(32(3)4)70(65-27-17-24-55)64-26-16-8-7-15-25-56-48(58)35-22-23-37-36(28-35)51(61)69-52(37)38-29-40(62-5)46(67-49(59)33-18-11-9-12-19-33)42(53)44(38)66-45-39(52)30-41(63-6)47(43(45)54)68-50(60)34-20-13-10-14-21-34/h22-23,28-34H,7-21,25-27H2,1-6H3,(H,56,58)
Synonyms: 4',5'-Dichloro-5-((6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamoyl)-2',7'-dimethoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl dicyclohexanecarboxylate; JOE phosphoramidite, 5-isomer (CHC protected); 3',6'-Bis(cyclohexylcarbonyloxy)-4',5'-dichloro-2',7'-dimethoxy-5-[6-(N,N-diisopropylamino-2-cyanoethoxyphosphinyloxy)hexylaminocarbonyl]-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]
6-JOE Phosphoramidite, CHC protected (BRP-02847)

6-JOE Phosphoramidite, CHC protected

Description: 6-JOE Phosphoramidite, CHC protected is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 6-carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein (6-JOE) fluorophore with a cyclohexylcarbonyl (CHC) protecting group on the phenolic hydroxyl groups of the JOE dye. The CHC protection enhances stability during synthesis and deprotection steps. It enables incorporation of the JOE label at the 5' end of DNA sequences during automated solid-phase synthesis, and is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02847
Molecular Formula: C52H64Cl2N3O12P
Molecular Weight: 1024.97
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InChIKey: REBMANJNAJRCSG-UHFFFAOYSA-N
SMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC2=C(C=C1)C(=O)OC23C4=CC(=C(C(=C4OC5=C(C(=C(C=C35)OC)OC(=O)C6CCCCC6)Cl)Cl)OC(=O)C7CCCCC7)OC)OCCC#N
IUPAC Name: [4',5'-dichloro-6-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(cyclohexanecarbonyloxy)-2',7'-dimethoxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] cyclohexanecarboxylate
InChI: InChI=1S/C52H64Cl2N3O12P/c1-31(2)57(32(3)4)70(65-27-17-24-55)64-26-16-8-7-15-25-56-48(58)35-22-23-36-37(28-35)52(69-51(36)61)38-29-40(62-5)46(67-49(59)33-18-11-9-12-19-33)42(53)44(38)66-45-39(52)30-41(63-6)47(43(45)54)68-50(60)34-20-13-10-14-21-34/h22-23,28-34H,7-21,25-27H2,1-6H3,(H,56,58)
Synonyms: 4',5'-Dichloro-6-((6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamoyl)-2',7'-dimethoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl dicyclohexanecarboxylate; JOE phosphoramidite, 6-isomer (CHC protected); 3',6'-Bis(cyclohexylcarbonyloxy)-4',5'-dichloro-2',7'-dimethoxy-6-[6-(N,N-diisopropylamino-2-cyanoethoxyphosphinyloxy)hexylaminocarbonyl]-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]
6-JOE cyclohexyl Phosphoramidite, CHC protected (BRP-02848)

6-JOE cyclohexyl Phosphoramidite, CHC protected

Description: 6-JOE cyclohexyl Phosphoramidite, CHC protected is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 6-carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein (6-JOE) fluorophore attached to a cyclohexyl phosphoramidite moiety, with cyclohexylcarbonyl (CHC) protecting groups on the phenolic hydroxyl groups of the JOE dye. The CHC protection enhances stability during synthesis and deprotection steps. It enables incorporation of the 6-JOE label at the 5' end of DNA sequences during automated solid-phase synthesis, and is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02848
CAS: 1353002-87-5
Molecular Formula: C52H62Cl2N3O12P
Molecular Weight: 1022.95
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InChIKey: MPUWSUKIUOOMIS-UHFFFAOYSA-N
SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CCC(CC1)NC(=O)C2=CC3=C(C=C2)C(=O)OC34C5=CC(=C(C(=C5OC6=C(C(=C(C=C46)OC)OC(=O)C7CCCCC7)Cl)Cl)OC(=O)C8CCCCC8)OC
IUPAC Name: [4',5'-dichloro-6-[[4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxycyclohexyl]carbamoyl]-6'-(cyclohexanecarbonyloxy)-2',7'-dimethoxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] cyclohexanecarboxylate
InChI: InChI=1S/C52H62Cl2N3O12P/c1-29(2)57(30(3)4)70(64-25-13-24-55)69-35-21-19-34(20-22-35)56-48(58)33-18-23-36-37(26-33)52(68-51(36)61)38-27-40(62-5)46(66-49(59)31-14-9-7-10-15-31)42(53)44(38)65-45-39(52)28-41(63-6)47(43(45)54)67-50(60)32-16-11-8-12-17-32/h18,23,26-32,34-35H,7-17,19-22,25H2,1-6H3,(H,56,58)
Synonyms: 4',5'-Dichloro-6-((4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)cyclohexyl)carbamoyl)-2',7'-dimethoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl dicyclohexanecarboxylate; 6-JOE Phosphoramidite ACH, CHC protected
6-JOE Phosphoramidite (hydroxyprolinol), CHC protected (BRP-02849)

6-JOE Phosphoramidite (hydroxyprolinol), CHC protected

Description: 6-JOE Phosphoramidite (hydroxyprolinol), CHC protected is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 6-carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein (6-JOE) fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety, with cyclohexylcarbonyl (CHC) protecting groups on the phenolic hydroxyl groups of the JOE dye. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold, while the CHC protection enhances stability during synthesis and deprotection steps. It enables incorporation of the 6-JOE label at the 5' end of DNA sequences during automated solid-phase synthesis, and is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02849
Molecular Formula: C78H89Cl2N4O16P
Molecular Weight: 1440.46
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InChIKey: SAFJTGYBQAEHBP-CQSLGVROSA-N
SMILES: ClC(C1=C2C3(C4=CC(C(NCCCCCC(N5[C@H](COC(C6=CC=CC=C6)(C7=CC=C(OC)C=C7)C8=CC=C(OC)C=C8)C[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C5)=O)=O)=CC=C4C(O3)=O)C(C=C9OC)=C(O1)C(Cl)=C9OC(C%10CCCCC%10)=O)=C(C(OC)=C2)OC(C%11CCCCC%11)=O
InChI: InChI=1S/C78H89Cl2N4O16P/c1-48(2)84(49(3)4)101(95-41-21-39-81)100-59-43-56(47-94-77(53-26-17-11-18-27-53,54-30-34-57(90-5)35-31-54)55-32-36-58(91-6)37-33-55)83(46-59)66(85)28-19-12-20-40-82-73(86)52-29-38-60-61(42-52)78(99-76(60)89)62-44-64(92-7)71(97-74(87)50-22-13-9-14-23-50)67(79)69(62)96-70-63(78)45-65(93-8)72(68(70)80)98-75(88)51-24-15-10-16-25-51/h11,17-18,26-27,29-38,42,44-45,48-51,56,59H,9-10,12-16,19-25,28,40-41,43,46-47H2,1-8H3,(H,82,86)/t56-,59+,101?/m0/s1
Synonyms: 6-JOE Pro Phosphoramidite; JOE phosphoramidite, 6-isomer (hydroxyprolinol), CHC protected; 6-((6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamoyl)-4',5'-dichloro-2',7'-dimethoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl dicyclohexanecarboxylate
5-TET Pro Phosphoramidite (BRP-02850)

5-TET Pro Phosphoramidite

Description: 5-TET Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 5-carboxy-4,7,2',7'-tetrachlorofluorescein (5-TET) fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the TET label at the 5' end of DNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02850
Molecular Formula: C72H79Cl4N4O14P
Molecular Weight: 1397.21
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InChIKey: XZTRNJIAZQICEA-MZXSDKSGSA-N
SMILES: COC(C=C1)=CC=C1C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCNC(C4=CC(Cl)=C(C56C(C=C7Cl)=C(OC8=C5C=C(Cl)C(OC(C(C)(C)C)=O)=C8)C=C7OC(C(C)(C)C)=O)C(C(O6)=O)=C4Cl)=O)=O)OP(N(C(C)C)C(C)C)OCCC#N)C9=CC=C(C=C9)OC
InChI: InChI=1S/C72H79Cl4N4O14P/c1-42(2)80(43(3)4)95(89-33-19-31-77)94-50-34-47(41-88-71(44-20-15-13-16-21-44,45-23-27-48(86-11)28-24-45)46-25-29-49(87-12)30-26-46)79(40-50)61(81)22-17-14-18-32-78-65(82)51-35-56(75)63-62(64(51)76)66(83)93-72(63)52-36-54(73)59(91-67(84)69(5,6)7)38-57(52)90-58-39-60(55(74)37-53(58)72)92-68(85)70(8,9)10/h13,15-16,20-21,23-30,35-39,42-43,47,50H,14,17-19,22,32-34,40-41H2,1-12H3,(H,78,82)/t47-,50+,95?/m0/s1
Synonyms: 5-Tetrachloro-Fluorescein Pro Phosphoramidite; TET Phosphoramidite, 5-isomer (hydroxyprolinol); Tetrachloro Phosphoramidite, 5-isomer (hydroxyprolinol); 5-((6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamoyl)-2',4,7,7'-tetrachloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)
6-TET Pro Phosphoramidite (BRP-02851)

6-TET Pro Phosphoramidite

Description: 6-TET Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 6-carboxy-4,7,2',7'-tetrachlorofluorescein (6-TET) fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the TET label at the 5' end of DNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02851
Molecular Formula: C72H79Cl4N4O14P
Molecular Weight: 1397.21
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InChIKey: RWZBTOQWKZAVTJ-MZXSDKSGSA-N
SMILES: COC(C=C1)=CC=C1C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCNC(C(C(Cl)=C4C56C(C=C7Cl)=C(OC8=C5C=C(Cl)C(OC(C(C)(C)C)=O)=C8)C=C7OC(C(C)(C)C)=O)=CC(Cl)=C4C(O6)=O)=O)=O)OP(N(C(C)C)C(C)C)OCCC#N)C9=CC=C(C=C9)OC
InChI: InChI=1S/C72H79Cl4N4O14P/c1-42(2)80(43(3)4)95(89-33-19-31-77)94-50-34-47(41-88-71(44-20-15-13-16-21-44,45-23-27-48(86-11)28-24-45)46-25-29-49(87-12)30-26-46)79(40-50)61(81)22-17-14-18-32-78-65(82)51-35-56(75)62-63(64(51)76)72(93-66(62)83)52-36-54(73)59(91-67(84)69(5,6)7)38-57(52)90-58-39-60(55(74)37-53(58)72)92-68(85)70(8,9)10/h13,15-16,20-21,23-30,35-39,42-43,47,50H,14,17-19,22,32-34,40-41H2,1-12H3,(H,78,82)/t47-,50+,95?/m0/s1
Synonyms: 6-Tetrachloro-Fluorescein Pro Phosphoramidite; TET Phosphoramidite, 6-isomer (hydroxyprolinol); Tetrachloro Phosphoramidite, 6-isomer (hydroxyprolinol); 6-((6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamoyl)-2',4,7,7'-tetrachloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)
5-HEX Pro Phosphoramidite (BRP-02852)

5-HEX Pro Phosphoramidite

Description: 5-HEX Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 5-carboxy-2',4,4',5',7,7'-hexachlorofluorescein (5-HEX) fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the HEX label at the 5' end of DNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02852
Molecular Formula: C72H77Cl6N4O14P
Molecular Weight: 1466.10
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InChIKey: KXANPIGIVIGYEX-UMUCQOALSA-N
SMILES: COC(C=C1)=CC=C1C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCNC(C4=CC(Cl)=C(C56C(C=C7Cl)=C(OC8=C5C=C(Cl)C(OC(C(C)(C)C)=O)=C8Cl)C(Cl)=C7OC(C(C)(C)C)=O)C(C(O6)=O)=C4Cl)=O)=O)OP(N(C(C)C)C(C)C)OCCC#N)C9=CC=C(C=C9)OC
InChI: InChI=1S/C72H77Cl6N4O14P/c1-40(2)82(41(3)4)97(91-33-19-31-79)96-48-34-45(39-90-71(42-20-15-13-16-21-42,43-23-27-46(88-11)28-24-43)44-25-29-47(89-12)30-26-44)81(38-48)55(83)22-17-14-18-32-80-65(84)49-35-52(73)57-56(58(49)76)66(85)95-72(57)50-36-53(74)63(93-67(86)69(5,6)7)59(77)61(50)92-62-51(72)37-54(75)64(60(62)78)94-68(87)70(8,9)10/h13,15-16,20-21,23-30,35-37,40-41,45,48H,14,17-19,22,32-34,38-39H2,1-12H3,(H,80,84)/t45-,48+,97?/m0/s1
Synonyms: 5-Hexachloro-Fluorescein Pro Phosphoramidite; HEX Phosphoramidite, 5-isomer (hydroxyprolinol); Hexachloro Phosphoramidite, 5-isomer (hydroxyprolinol); 5-((6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamoyl)-2',4,4',5',7,7'-hexachloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)
6-HEX Pro Phosphoramidite (BRP-02853)

6-HEX Pro Phosphoramidite

Description: 6-HEX Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 6-carboxy-2',4,4',5',7,7'-hexachlorofluorescein (6-HEX) fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the HEX label at the 5' end of DNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02853
Molecular Formula: C72H77Cl6N4O14P
Molecular Weight: 1466.10
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InChIKey: BONLXSJHOISCAS-UMUCQOALSA-N
SMILES: COC(C=C1)=CC=C1C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCNC(C(C(Cl)=C4C56C(C=C7Cl)=C(OC8=C5C=C(Cl)C(OC(C(C)(C)C)=O)=C8Cl)C(Cl)=C7OC(C(C)(C)C)=O)=CC(Cl)=C4C(O6)=O)=O)=O)OP(N(C(C)C)C(C)C)OCCC#N)C9=CC=C(C=C9)OC
InChI: InChI=1S/C72H77Cl6N4O14P/c1-40(2)82(41(3)4)97(91-33-19-31-79)96-48-34-45(39-90-71(42-20-15-13-16-21-42,43-23-27-46(88-11)28-24-43)44-25-29-47(89-12)30-26-44)81(38-48)55(83)22-17-14-18-32-80-65(84)49-35-52(73)56-57(58(49)76)72(95-66(56)85)50-36-53(74)63(93-67(86)69(5,6)7)59(77)61(50)92-62-51(72)37-54(75)64(60(62)78)94-68(87)70(8,9)10/h13,15-16,20-21,23-30,35-37,40-41,45,48H,14,17-19,22,32-34,38-39H2,1-12H3,(H,80,84)/t45-,48+,97?/m0/s1
Synonyms: 6-Hexachloro-Fluorescein Pro Phosphoramidite; HEX Phosphoramidite, 6-isomer (hydroxyprolinol); Hexachloro Phosphoramidite, 6-isomer (hydroxyprolinol); 6-((6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamoyl)-2',4,4',5',7,7'-hexachloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)
6-TAMRA cyclohexyl phosphoramidite (BRP-02854)

6-TAMRA cyclohexyl phosphoramidite

Description: 6-TAMRA cyclohexyl phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 6-carboxytetramethylrhodamine (6-TAMRA) fluorophore attached to a cyclohexyl phosphoramidite moiety, enabling incorporation of the TAMRA label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It is widely used in molecular biology applications including DNA sequencing, real-time PCR, fluorescence resonance energy transfer (FRET) studies, and dual-labeled probe synthesis.
CAT: BRP-02854
Molecular Formula: C40H50N5O6P
Molecular Weight: 727.83
Appearance: Red solid
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Storage: Store at -20 °C
InChIKey: WAXFLCDSTVMRSD-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DCM
SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CCC(CC1)NC(=O)C2=CC3=C(C=C2)C(=O)OC34C5=C(C=C(C=C5)N(C)C)OC6=C4C=CC(=C6)N(C)C
IUPAC Name: N-[4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxycyclohexyl]-3',6'-bis(dimethylamino)-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxamide
InChI: InChI=1S/C40H50N5O6P/c1-25(2)45(26(3)4)52(48-21-9-20-41)51-31-15-11-28(12-16-31)42-38(46)27-10-17-32-35(22-27)40(50-39(32)47)33-18-13-29(43(5)6)23-36(33)49-37-24-30(44(7)8)14-19-34(37)40/h10,13-14,17-19,22-26,28,31H,9,11-12,15-16,21H2,1-8H3,(H,42,46)
Synonyms: TAMRA phosphoramidite, 6-isomer; 6-TAMRA phosphoramidite; 4-(3',6'-Bis(dimethylamino)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxamido)cyclohexyl (2-cyanoethyl) diisopropylphosphoramidite; 6-TAMRA Phosphoramidite ACH
6-R6G cyclohexyl Phosphoramidite (BRP-02855)

6-R6G cyclohexyl Phosphoramidite

Description: 6-R6G cyclohexyl Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 6-carboxyrhodamine 6G (6-R6G) fluorophore attached to a cyclohexyl phosphoramidite moiety, enabling incorporation of the R6G label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, fragment analysis, and fluorescence resonance energy transfer (FRET) applications.
CAT: BRP-02855
Molecular Formula: C46H52F6N5O8P
Molecular Weight: 947.91
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InChIKey: BUKZOVIUGRKPCD-UHFFFAOYSA-N
SMILES: N#CCCOP(N(C(C)C)C(C)C)OC(CC1)CCC1NC(C2=CC3=C(C(OC43C(C=C5C)=C(OC(C=C6N(C(C(F)(F)F)=O)CC)=C4C=C6C)C=C5N(C(C(F)(F)F)=O)CC)=O)C=C2)=O
InChI: InChI=1S/C46H52F6N5O8P/c1-9-55(42(60)45(47,48)49)36-23-38-34(20-27(36)7)44(35-21-28(8)37(24-39(35)63-38)56(10-2)43(61)46(50,51)52)33-22-29(12-17-32(33)41(59)64-44)40(58)54-30-13-15-31(16-14-30)65-66(62-19-11-18-53)57(25(3)4)26(5)6/h12,17,20-26,30-31H,9-11,13-16,19H2,1-8H3,(H,54,58)
Synonyms: 6-R6G Phosphoramidite; R6G cyclohexyl Phosphoramidite, 6-isomer; 4-(3',6'-Bis(N-ethyl-2,2,2-trifluoroacetamido)-2',7'-dimethyl-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxamido)cyclohexyl (2-cyanoethyl) diisopropylphosphoramidite; 6-R6G Phosphoramidite ACH
6-ROX Pro Phosphoramidite (BRP-02856)

6-ROX Pro Phosphoramidite

Description: 6-ROX Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a 6-carboxy-X-rhodamine (6-ROX) fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the ROX label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, fragment analysis, and fluorescence resonance energy transfer (FRET) applications.
CAT: BRP-02856
Molecular Formula: C74H85N6O10P
Molecular Weight: 1249.50
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InChIKey: JZRVASIEKRDEKG-KQQXPPNUSA-N
SMILES: N#CCCOP(N(C(C)C)C(C)C)O[C@@H](C1)C[C@@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N1C(CCCCCNC(C5=CC=C(C6=C5)C(OC76C8=C(C9=C%10N(CCCC%10=C8)CCC9)OC%11=C7C=C%12CCCN%13CCCC%11=C%12%13)=O)=O)=O
InChI: InChI=1S/C74H85N6O10P/c1-48(2)80(49(3)4)91(87-41-17-35-75)90-59-45-56(47-86-73(53-20-9-7-10-21-53,54-26-30-57(84-5)31-27-54)55-28-32-58(85-6)33-29-55)79(46-59)66(81)24-11-8-12-36-76-71(82)52-25-34-60-63(44-52)74(89-72(60)83)64-42-50-18-13-37-77-39-15-22-61(67(50)77)69(64)88-70-62-23-16-40-78-38-14-19-51(68(62)78)43-65(70)74/h7,9-10,20-21,25-34,42-44,48-49,56,59H,8,11-19,22-24,36-41,45-47H2,1-6H3,(H,76,82)/t56-,59+,91?/m0/s1
Synonyms: 6-ROX Phosphoramidite (hydroxyprolinol); ROX Pro Phosphoramidite, 6-isomer; ROX Phosphoramidite, 6-isomer (hydroxyprolinol)
By-3 Pro Phosphoramidite (BRP-02857)

By-3 Pro Phosphoramidite

Description: By-3 Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a By-3 fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the By-3 label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02857
Molecular Formula: C65H81BF4N5O6P
Molecular Weight: 1146.17
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InChIKey: DUSPVBGYZWCGOL-LHVZTRALSA-N
SMILES: COC1=CC=C(C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCN4C5=C(C(C)(/C4=C\C=C\C6=[N+](C7=C(C(C)6C)C=CC=C7)C)C)C=CC=C5)=O)OP(OCCC#N)N(C(C)C)C(C)C)C(C=C8)=CC=C8OC)C=C1
InChI: InChI=1S/C65H81N5O6P/c1-47(2)70(48(3)4)77(75-43-23-41-66)76-55-44-52(46-74-65(49-24-14-12-15-25-49,50-33-37-53(72-10)38-34-50)51-35-39-54(73-11)40-36-51)69(45-55)62(71)32-16-13-21-42-68-59-29-20-18-27-57(59)64(7,8)61(68)31-22-30-60-63(5,6)56-26-17-19-28-58(56)67(60)9/h12,14-15,17-20,22,24-31,33-40,47-48,52,55H,13,16,21,23,32,42-46H2,1-11H3/q+1/t52-,55+,77?/m0/s1
Synonyms: Cyanine3 Pro Phosphoramidite tetrafluoroborate; Cyanine3 Phosphoramidite (hydroxyprolinol) tetrafluoroborate; Cy3 Pro Phosphoramidite tetrafluoroborate; 2-((E)-3-((E)-1-(6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)-3,3-dimethylindolin-2-ylidene)prop-1-en-1-yl)-1,3,3-trimethyl-3H-indol-1-ium tetrafluoroborate
By-5 Pro Phosphoramidite (BRP-02858)

By-5 Pro Phosphoramidite

Description: By-5 Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a By-5 fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the By-5 label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02858
Molecular Formula: C67H83BF4N5O6P
Molecular Weight: 1172.21
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InChIKey: CUQLDYPHATVPHW-PWFKFRGLSA-M
SMILES: FB(F)F.COC1=CC=C(C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCN4C5=C(C(C)(/C4=C\C=C\C=C\C6=[N+](C7=C(C(C)6C)C=CC=C7)C)C)C=CC=C5)=O)OP(OCCC#N)N(C(C)C)C(C)C)C(C=C8)=CC=C8OC)C=C1.[F-]
InChI: InChI=1S/C67H83N5O6P.BF3.FH/c1-49(2)72(50(3)4)79(77-45-25-43-68)78-57-46-54(48-76-67(51-26-15-12-16-27-51,52-35-39-55(74-10)40-36-52)53-37-41-56(75-11)42-38-53)71(47-57)64(73)34-19-14-24-44-70-61-31-23-21-29-59(61)66(7,8)63(70)33-18-13-17-32-62-65(5,6)58-28-20-22-30-60(58)69(62)9;2-1(3)4;/h12-13,15-18,20-23,26-33,35-42,49-50,54,57H,14,19,24-25,34,44-48H2,1-11H3;;1H/q+1;;/p-1/t54-,57+,79?;;/m0../s1
Synonyms: Cyanine5 Pro Phosphoramidite tetrafluoroborate; Cyanine5 Phosphoramidite (hydroxyprolinol) tetrafluoroborate; Cy5 Pro Phosphoramidite tetrafluoroborate; 2-((1E,3E)-5-((E)-1-(6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)-3,3-dimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-1,3,3-trimethyl-3H-indol-1-ium tetrafluoroborate
By-3.5 Pro Phosphoramidite (BRP-02859)

By-3.5 Pro Phosphoramidite

Description: By-3.5 Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a By-3.5 fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the By-3.5 label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02859
Molecular Formula: C76H91BF4N5O6P
Molecular Weight: 1288.37
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InChIKey: MFTGQLFAOMHUQN-FTOOFCBGSA-M
SMILES: FB(F)F.COC1=CC=C(C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCN4C5=C(C(C)(/C4=C\C=C\C6=[N+](C7=C(C(C)6C)C8=CC=CC=C8C=C7)CCCC)C)C9=CC=CC=C9C=C5)=O)OP(OCCC#N)N(C(C)C)C(C)C)C(C=C%10)=CC=C%10OC)C=C1.[F-]
InChI: InChI=1S/C76H91N5O6P.BF3.FH/c1-12-13-48-78-67-45-35-56-26-19-21-30-65(56)72(67)74(6,7)69(78)32-24-33-70-75(8,9)73-66-31-22-20-27-57(66)36-46-68(73)79(70)49-23-15-18-34-71(82)80-52-64(87-88(86-50-25-47-77)81(54(2)3)55(4)5)51-61(80)53-85-76(58-28-16-14-17-29-58,59-37-41-62(83-10)42-38-59)60-39-43-63(84-11)44-40-60;2-1(3)4;/h14,16-17,19-22,24,26-33,35-46,54-55,61,64H,12-13,15,18,23,25,34,48-53H2,1-11H3;;1H/q+1;;/p-1/t61-,64+,88?;;/m0../s1
Synonyms: Cyanine3.5 Pro Phosphoramidite tetrafluoroborate; Cyanine3.5 Phosphoramidite (hydroxyprolinol) tetrafluoroborate; Cy3.5 Pro Phosphoramidite tetrafluoroborate; 2-((1E,3E)-3-(3-(6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)prop-1-en-1-yl)-3-butyl-1,1-dimethyl-1H-benzo[e]indol-3-ium tetrafluoroborate
By-5.5 Pro Phosphoramidite (BRP-02860)

By-5.5 Pro Phosphoramidite

Description: By-5.5 Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a By-5.5 fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the By-5.5 label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02860
Molecular Formula: C78H93BF4N5O6P
Molecular Weight: 1314.41
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InChIKey: KEXSLYZVXUTVMM-WSYKWAHBSA-M
SMILES: FB(F)F.COC1=CC=C(C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCN4C5=C(C(C)(/C4=C\C=C\C=C\C6=[N+](C7=C(C(C)6C)C8=C(C=CC=C8)C=C7)CCCC)C)C(C=CC=C9)=C9C=C5)=O)OP(OCCC#N)N(C(C)C)C(C)C)C(C=C%10)=CC=C%10OC)C=C1.[F-]
InChI: InChI=1S/C78H93N5O6P.BF3.FH/c1-12-13-50-80-69-47-37-58-28-22-24-32-67(58)74(69)76(6,7)71(80)34-19-15-20-35-72-77(8,9)75-68-33-25-23-29-59(68)38-48-70(75)81(72)51-26-16-21-36-73(84)82-54-66(89-90(88-52-27-49-79)83(56(2)3)57(4)5)53-63(82)55-87-78(60-30-17-14-18-31-60,61-39-43-64(85-10)44-40-61)62-41-45-65(86-11)46-42-62;2-1(3)4;/h14-15,17-20,22-25,28-35,37-48,56-57,63,66H,12-13,16,21,26-27,36,50-55H2,1-11H3;;1H/q+1;;/p-1/t63-,66+,90?;;/m0../s1
Synonyms: Cyanine5.5 Pro Phosphoramidite tetrafluoroborate; Cyanine5.5 Phosphoramidite (hydroxyprolinol) tetrafluoroborate; Cy5.5 Pro Phosphoramidite tetrafluoroborate; 2-((1E,3E,5E)-5-(3-(6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1,3-dien-1-yl)-3-butyl-1,1-dimethyl-1H-benzo[e]indol-3-ium tetrafluoroborate
BBQ-650 Pro Phosphoramidite (BRP-02861)

BBQ-650 Pro Phosphoramidite

Description: BBQ-650 Pro Phosphoramidite is a fluorescent labeling reagent used in oligonucleotide synthesis. It contains a BlackBerry Quencher 650 (BBQ-650) fluorophore attached to a hydroxyprolinol-based phosphoramidite moiety. BlackBerry Quencher (BBQ-650) exhibits a broad absorption profile from 550nm to 750nm, centered at 650nm. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the BBQ-650 label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It is commonly used in multiplex PCR, DNA sequencing, and fragment analysis applications.
CAT: BRP-02861
Molecular Formula: C71H87N10O12P
Molecular Weight: 1303.51
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InChIKey: WPSKKSDYOJEVMW-YEPVNGELSA-N
SMILES: COC1=CC=C(C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCNC(CCCOC4=C(N=NC5=CC(OC)=C(N=NC6=CC=C([N+]([O-])=O)C=C6)C=C5OC)C=C7CCCN8CCCC4=C87)=O)=O)OP(OCCC#N)N(C(C)C)C(C)C)C(C=C9)=CC=C9OC)C=C1
InChI: InChI=1S/C71H87N10O12P/c1-49(2)80(50(3)4)94(92-42-18-37-72)93-60-44-57(48-91-71(52-20-11-9-12-21-52,53-25-33-58(86-5)34-26-53)54-27-35-59(87-6)36-28-54)79(47-60)68(83)24-13-10-14-38-73-67(82)23-17-41-90-70-61-22-16-40-78-39-15-19-51(69(61)78)43-64(70)77-76-63-46-65(88-7)62(45-66(63)89-8)75-74-55-29-31-56(32-30-55)81(84)85/h9,11-12,20-21,25-36,43,45-46,49-50,57,60H,10,13-19,22-24,38-42,44,47-48H2,1-8H3,(H,73,82)/t57-,60+,94?/m0/s1
Synonyms: BBQ-650 Phosphoramidite (hydroxyprolinol); (3R,5S)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-1-(6-(4-((9-((2,5-dimethoxy-4-((4-nitrophenyl)diazenyl)phenyl)diazenyl)-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-yl)oxy)butanamido)hexanoyl)pyrrolidin-3-yl (2-cyanoethyl) diisopropylphosphoramidite
Iowa Black FQ Phosphoramidite (BRP-02862)

Iowa Black FQ Phosphoramidite

Description: Iowa Black FQ Phosphoramidite is a dark quencher reagent used in oligonucleotide synthesis. It contains an Iowa Black FQ non-fluorescent chromophore attached to a phosphoramidite moiety, enabling efficient incorporation at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It efficiently quenches fluorescence in the 420-620 nm range via Förster resonance energy transfer (FRET), making it ideal for dual-labeled probe synthesis such as TaqMan probes, molecular beacons, and other real-time PCR applications.
CAT: BRP-02862
CAS: 852203-68-0
Molecular Formula: C50H55N6O7P
Molecular Weight: 882.98
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Boiling Point: 903.5±65.0 °C at 760 mmHg
InChIKey: HNNXZGIKFPGCSE-UHFFFAOYSA-N
SMILES: CC(N(C(C)C)P(OCCC#N)OCCN(CCOC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)C4=CC=C(N=NC5=C6C=CC=CC6=C([N+]([O-])=O)C=C5)C=C4)C
InChI: InChI=1S/C50H55N6O7P/c1-37(2)55(38(3)4)64(62-34-12-31-51)63-36-33-54(43-23-21-42(22-24-43)52-53-48-29-30-49(56(57)58)47-16-11-10-15-46(47)48)32-35-61-50(39-13-8-7-9-14-39,40-17-25-44(59-5)26-18-40)41-19-27-45(60-6)28-20-41/h7-11,13-30,37-38H,12,32-36H2,1-6H3
Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 2-[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][4-[(4-nitro-1-naphthalenyl)azo]phenyl]amino]ethyl 2-cyanoethyl ester; 2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)(4-((4-nitronaphthalen-1-yl)diazenyl)phenyl)amino)ethyl (2-cyanoethyl) diisopropylphosphoramidite
Iowa Black RQ Pro Phosphoramidite (BRP-02863)

Iowa Black RQ Pro Phosphoramidite

Description: Iowa Black RQ Pro Phosphoramidite is a dark quencher reagent used in oligonucleotide synthesis. It contains an Iowa Black RQ non-fluorescent chromophore attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the Iowa Black RQ quencher at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. It efficiently quenches fluorescence in the 500-700 nm range via Förster resonance energy transfer (FRET), making it ideal for dual-labeled probe synthesis such as TaqMan probes, molecular beacons, and other real-time PCR applications.
CAT: BRP-02863
Molecular Formula: C64H73N6O10P
Molecular Weight: 1117.29
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InChIKey: SIGTYCYKBKERGZ-OPIRNBENSA-N
SMILES: COC1=CC=C(C(C2=CC=CC=C2)(OC[C@@H]3C[C@H](CN3C(CCCCCNC(OCCNC(C(C(C4=C5C=CC=C4)=O)=C6C5=O)=CC=C6NC7=CC=CC=C7)=O)=O)OP(OCCC#N)N(C(C)C)C(C)C)C(C=C8)=CC=C8OC)C=C1
InChI: InChI=1S/C64H73N6O10P/c1-44(2)70(45(3)4)81(79-39-18-36-65)80-53-41-50(43-78-64(46-19-10-7-11-20-46,47-26-30-51(75-5)31-27-47)48-28-32-52(76-6)33-29-48)69(42-53)58(71)25-14-9-17-37-67-63(74)77-40-38-66-56-34-35-57(68-49-21-12-8-13-22-49)60-59(56)61(72)54-23-15-16-24-55(54)62(60)73/h7-8,10-13,15-16,19-24,26-35,44-45,50,53,66,68H,9,14,17-18,25,37-43H2,1-6H3,(H,67,74)/t50-,53+,81?/m0/s1
Synonyms: 2-((9,10-Dioxo-4-(phenylamino)-9,10-dihydroanthracen-1-yl)amino)ethyl (6-((2S,4R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamate; Iowa Black RQ Phosphoramidite (hydroxyprolinol)
Alkyne-Doubler Phosphoramidite (BRP-02864)

Alkyne-Doubler Phosphoramidite

Description: Alkyne-Doubler Phosphoramidite is a branching reagent used in oligonucleotide synthesis. It contains a phosphoramidite moiety with a doubler alkyne structure, enabling the introduction of multiple alkyne sites within an oligonucleotide chain. The doubler alkyne architecture facilitates dendritic branching and subsequent bioorthogonal click chemistry modifications, allowing the synthesis of multivalent or highly functionalized oligonucleotides.
CAT: BRP-02864
CAS: 2223630-43-9
Molecular Formula: C53H75N2O11P
Molecular Weight: 947.15
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Boiling Point: 866.3±65.0 °C at 760 mmHg
InChIKey: YSAQKJSBKQEVFV-UHFFFAOYSA-N
SMILES: N#CCCOP(OCCCOCC(COCCCOCC#C)(COCCCOCC#C)COCCCOC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)N(C(C)C)C(C)C
InChI: InChI=1S/C53H75N2O11P/c1-9-30-58-32-15-34-60-41-52(42-61-35-16-33-59-31-10-2,44-63-37-18-40-66-67(65-39-14-29-54)55(45(3)4)46(5)6)43-62-36-17-38-64-53(47-19-12-11-13-20-47,48-21-25-50(56-7)26-22-48)49-23-27-51(57-8)28-24-49/h1-2,11-13,19-28,45-46H,14-18,30-44H2,3-8H3
Synonyms: 3-(3-(3-(Bis(4-methoxyphenyl)(phenyl)methoxy)propoxy)-2,2-bis((3-(prop-2-yn-1-yloxy)propoxy)methyl)propoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite

Frequently Asked Questions (FAQ)

What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

* Only for research. Not suitable for any diagnostic or therapeutic use.

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