Phosphoramidites

TAO-G CE Phosphoramdite

Description: TAO-G CE Phosphoramdite is a dual-quenching phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of the TAO-G moiety at the 5'-terminus of DNA/RNA strands. This dual-quencher system efficiently quenches fluorescence through both static and dynamic mechanisms, significantly reducing background signal and enhancing signal-to-noise ratios in molecular beacon probes, real-time PCR assays, and other fluorescence-based applications.

CAT: BRP-02667

Molecular Formula: C55H58N5O8P

Molecular Weight: 948.07

Purity: ≥95%

Appearance: Blue solid

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InChIKey: HUSKZYBHPWFHAV-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OCC(COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)NC(CNC(C=CC(NC4=CC=CC=C4)=C5C(C6=C7C=CC=C6)=O)=C5C7=O)=O)OCCC#N)C

IUPAC Name: 3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(2-((9,10-dioxo-4-(phenylamino)-9,10-dihydroanthracen-1-yl)amino)acetamido)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H58N5O8P/c1-37(2)60(38(3)4)69(67-33-15-32-56)68-36-43(35-66-55(39-16-9-7-10-17-39,40-22-26-44(64-5)27-23-40)41-24-28-45(65-6)29-25-41)59-50(61)34-57-48-30-31-49(58-42-18-11-8-12-19-42)52-51(48)53(62)46-20-13-14-21-47(46)54(52)63/h7-14,16-31,37-38,43,57-58H,15,33-36H2,1-6H3,(H,59,61)

Synonyms: TAO-G Phosphoramidite

Endo BCN-PEG3 CE Phosphoramidite

Description: Endo BCN-PEG3 CE Phosphoramidite is a phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of an endo-bicyclononyne (BCN) group functionalized with a PEG3 spacer into DNA or RNA strands. The BCN moiety facilitates copper-free click chemistry reactions, specifically strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules or inverse electron demand Diels-Alder (IEDDA) reactions with tetrazines, allowing post-synthetic conjugation to labels, surfaces, or biomolecules. The PEG3 linker enhances water solubility and biocompatibility, reducing non-specific interactions and improving the stability of the conjugated oligonucleotides.

CAT: BRP-02668

Molecular Formula: C28H48N3O7P

Molecular Weight: 569.68

Purity: ≥95%

Appearance: Slight yellow oily matter

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InChIKey: BUMXYCDWEZVUQG-UWZSUSAUSA-N

CanonicalSMILES: CC(N(P(OCCC#N)OCCOCCOCCOCCNC(OC[C@@H]1[C@]2([H])CCC#CCC[C@@]21[H])=O)C(C)C)C

IUPAC Name: ((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2-(2-(2-(2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate

InChI: InChI=1S/C28H48N3O7P/c1-23(2)31(24(3)4)39(37-14-9-12-29)38-21-20-35-19-18-34-17-16-33-15-13-30-28(32)36-22-27-25-10-7-5-6-8-11-26(25)27/h23-27H,7-11,13-22H2,1-4H3,(H,30,32)/t25-,26+,27-,39?

Synonyms: Endo BCN-PEG3 Phosphoramidite

Amino-Modifier C3 CE Phosphoramidite

Description: Amino-Modifier C3 CE Phosphoramidite is a reagent used in automated oligonucleotide synthesis to introduce an amino group at the 5' end of nucleic acids. This modification is achieved through a phosphoramidite linkage and is useful for creating modified oligonucleotides with enhanced properties. The C3 spacer allows for a three-carbon interval between the amino group and the nucleic acid backbone, providing a suitable distance for subsequent conjugation with various molecules. This reagent is commonly used in applications such as drug discovery, gene synthesis, and molecular diagnostics.

CAT: BRP-02669

CAS: 258343-51-0

Molecular Formula: C35H43F3N3O6P

Molecular Weight: 689.71

Purity: ≥97%

Appearance: Colourless oily matter

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Boiling Point: 693.5±55.0 °C at 760 mmHg

InChIKey: HISMCSMWIYBWHF-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CNC(=O)C(F)(F)F)COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

IUPAC Name: N-[3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C35H43F3N3O6P/c1-25(2)41(26(3)4)48(46-22-10-21-39)47-32(23-40-33(42)35(36,37)38)24-45-34(27-11-8-7-9-12-27,28-13-17-30(43-5)18-14-28)29-15-19-31(44-6)20-16-29/h7-9,11-20,25-26,32H,10,22-24H2,1-6H3,(H,40,42)

Synonyms: Amino-Modifier C3 Phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-2-[(trifluoroacetyl)amino]ethyl 2-cyanoethyl ester; 1-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-(2,2,2-trifluoroacetamido)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

HPro CE Phosphoramidite

Description: HPro CE Phosphoramidite is a specialized phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of the HPro modifier into DNA or RNA strands. It is particularly useful for introducing functional groups or labels into oligonucleotides, facilitating applications in molecular diagnostics, therapeutics, or research tools requiring post-synthetic modifications.

CAT: BRP-02671

CAS: 1445145-68-5

Molecular Formula: C37H45F3N3O6P

Molecular Weight: 715.75

Purity: ≥97%

Appearance: Off-white solid

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Boiling Point: 712.9±60.0 °C at 760 mmHg

InChIKey: JKBXEFCHTNRDHZ-IGCNUVEYSA-N

CanonicalSMILES: N#CCCOP(OC1CN(C(=O)C(F)(F)F)C(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N(C(C)C)C(C)C

IUPAC Name: (3R,5S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-1-(2,2,2-trifluoroacetyl)pyrrolidin-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C37H45F3N3O6P/c1-26(2)43(27(3)4)50(48-22-10-21-41)49-34-23-31(42(24-34)35(44)37(38,39)40)25-47-36(28-11-8-7-9-12-28,29-13-17-32(45-5)18-14-29)30-15-19-33(46-6)20-16-30/h7-9,11-20,26-27,31,34H,10,22-25H2,1-6H3/t31-,34+,50?/m0/s1

Synonyms: HPro Phosphoramidite; (3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-(2,2,2-trifluoroacetyl)-3-pyrrolidinyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-(2,2,2-trifluoroacetyl)-3-pyrrolidinyl 2-cyanoethyl ester

Spermine CE Phosphoramidite (unprotected)

Description: Spermine CE Phosphoramidite (unprotected) is a specialized phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of spermine moieties into DNA or RNA strands. This reagent facilitates the creation of Zip Nucleic Acids (ZNAs), where the cationic spermine groups reduce electrostatic repulsion between the oligonucleotide and its target, significantly enhancing binding affinity and stability of the duplex. ZNAs are widely used in applications such as multiplex PCR, RT-qPCR, microRNA detection, and antisense/antigene therapies due to their improved hybridization kinetics and cellular uptake.

CAT: BRP-02674

CAS: 1969276-81-0

Molecular Formula: C48H77N6O5P

Molecular Weight: 849.14

Purity: ≥97%

Appearance: Colourless oily matter

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Boiling Point: 840.0±65.0 °C at 760 mmHg

InChIKey: YMDADIHGMHJYIE-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCNCCCNCCCCNCCCNCCCCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 1,1-bis(4-methoxyphenyl)-1-phenyl-2-oxa-7,11,16,20-tetraazatetracosan-24-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H77N6O5P/c1-41(2)54(42(3)4)60(59-40-16-29-49)58-39-15-13-33-53-37-18-35-51-31-11-10-30-50-34-17-36-52-32-12-14-38-57-48(43-19-8-7-9-20-43,44-21-25-46(55-5)26-22-44)45-23-27-47(56-6)28-24-45/h7-9,19-28,41-42,50-53H,10-18,30-40H2,1-6H3

Synonyms: Spermine Phosphoramidite (unprotected); Phosphoramidous acid, N,N-bis(1-methylethyl)-, 24,24-bis(4-methoxyphenyl)-24-phenyl-23-oxa-5,9,14,18-tetraazatetracos-1-yl 2-cyanoethyl ester; Spermine CE Phosphoramidite

Related CAS: 1969276-82-1 (tetra-TFA salt) ; 942054-48-0 (Spermine Phosphoramidite (NTFA-protected))

DNP CE Phosphoramidite

Description: DNP CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a dinitrophenyl (DNP) group into DNA or RNA strands. The DNP moiety serves as a versatile chemical handle for post-synthetic conjugation or detection, facilitating applications such as hapten labeling for immunoassays, molecular diagnostics, or affinity purification.

CAT: BRP-02675

CAS: 136949-85-4

Molecular Formula: C21H34N5O6P

Molecular Weight: 483.51

Purity: ≥97%

Appearance: Brown oily matter

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Boiling Point: 568.0±50.0 °C at 760 mmHg

InChIKey: FSQUUZFFAJZEPM-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCNC1=CC=C(C=C1N(=O)=O)N(=O)=O)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (6-((2,4-dinitrophenyl)amino)hexyl) diisopropylphosphoramidite

InChI: InChI=1S/C21H34N5O6P/c1-17(2)24(18(3)4)33(32-15-9-12-22)31-14-8-6-5-7-13-23-20-11-10-19(25(27)28)16-21(20)26(29)30/h10-11,16-18,23H,5-9,13-15H2,1-4H3

Synonyms: DNP Phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 6-[(2,4-dinitrophenyl)amino]hexyl ester

Desthiobiotin(N-BB) TEG CE Phosphoramidite

Description: Desthiobiotin(N-BB) TEG CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a desthiobiotin label with a triethylene glycol (TEG) spacer into DNA or RNA strands. The desthiobiotin moiety, a biotin derivative, binds to streptavidin with lower affinity (2×10^-9 M) compared to biotin (4×10^-14 M), allowing reversible capture and elution of labeled oligonucleotides under mild conditions (e.g., 95 °C in water or via biotin displacement). The TEG spacer provides a 15-atom linker to minimize steric hindrance, enhancing accessibility for streptavidin binding and facilitating applications in affinity purification, molecular diagnostics, and hybridization assays.

CAT: BRP-02676

Molecular Formula: C63H90N5O12P

Molecular Weight: 1140.41

Purity: ≥95%

Appearance: Off-white solid

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InChIKey: GUHQVSVLGODZAZ-WHJDPYJGSA-N

CanonicalSMILES: [H][C@]([C@@](CCCCCC(NCCCOCCOCCOCCOCC(COC(C1=CC=C(C=C1)OC)(C2=CC=CC=C2)C3=CC=C(C=C3)OC)OP(N(C(C)C)C(C)C)OCCC#N)=O)(NC4=O)[H])(N4C(C5=CC=C(C(C)(C)C)C=C5)=O)C

IUPAC Name: 25-((4R,5S)-1-(4-(tert-butyl)benzoyl)-5-methyl-2-oxoimidazolidin-4-yl)-1,1-bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azapentacosan-4-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C63H90N5O12P/c1-47(2)68(48(3)4)81(79-38-17-35-64)80-57(46-78-63(52-19-13-11-14-20-52,53-27-31-55(72-9)32-28-53)54-29-33-56(73-10)34-30-54)45-77-44-43-76-42-41-75-40-39-74-37-18-36-65-59(69)22-16-12-15-21-58-49(5)67(61(71)66-58)60(70)50-23-25-51(26-24-50)62(6,7)8/h11,13-14,19-20,23-34,47-49,57-58H,12,15-18,21-22,36-46H2,1-10H3,(H,65,69)(H,66,71)/t49-,57?,58+,81?/m0/s1

Synonyms: Desthiobiotin(N-BB) TEG Phosphoramidite

Biotin(N-BB) TEG CE Phosphoramidite

Description: Biotin(N-BB) TEG CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a biotin label with a triethylene glycol (TEG) spacer into DNA or RNA strands. The reagent features a tert-butylbenzoyl (N-BB) protecting group on the biotin moiety to enhance solubility and prevent side reactions during synthesis. The TEG spacer provides a 15-atom linker between the biotin and the oligonucleotide, reducing steric hindrance and improving accessibility for binding to streptavidin or avidin in downstream applications. It is typically used to introduce biotin at the 5'-end or internally within an oligonucleotide sequence, facilitating applications such as molecular diagnostics, affinity purification, and hybridization assays.

CAT: BRP-02677

CAS: 1799331-53-5

Molecular Formula: C63H88N5O12PS

Molecular Weight: 1170.45

Purity: ≥95%

Appearance: Off-white solid

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InChIKey: ZJLRGMPCKKAODT-QBULNJHFSA-N

CanonicalSMILES: N#CCCOP(OC(COCCOCCOCCOCCCNC(=O)CCCCC1SCC2N(C(=O)NC12)C(=O)C3=CC=C(C=C3)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: 24-((3aS,4S,6aR)-1-(4-(tert-butyl)benzoyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-1,1-bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azatetracosan-4-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C63H88N5O12PS/c1-46(2)68(47(3)4)81(79-36-15-33-64)80-55(44-78-63(50-17-11-10-12-18-50,51-25-29-53(72-8)30-26-51)52-27-31-54(73-9)32-28-52)43-77-42-41-76-40-39-75-38-37-74-35-16-34-65-58(69)20-14-13-19-57-59-56(45-82-57)67(61(71)66-59)60(70)48-21-23-49(24-22-48)62(5,6)7/h10-12,17-18,21-32,46-47,55-57,59H,13-16,19-20,34-45H2,1-9H3,(H,65,69)(H,66,71)/t55?,56-,57-,59-,81?/m0/s1

Synonyms: Biotin(N-BB) TEG Phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-21-[(3aS,4S,6aR)-1-[4-(1,1-dimethylethyl)benzoyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-3,6,9,12-tetraoxa-16-azaheneicos-1-yl 2-cyanoethyl ester; 1-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-21-[(3aS,4S,6aR)-1-[4-(1,1-dimethylethyl)benzoyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-3,6,9,12-tetraoxa-16-azaheneicos-1-yl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Biotin (BB) TEG CE Phosphoramidite; Biotin (BB)-TEG CEP; Biotin (BB) TEG amidite

PC Spacer C6 CE Phosphoramidite

Description: PC Spacer C6 CE Phosphoramidite is a photocleavable spacer phosphoramidite designed for solid-phase oligonucleotide synthesis, enabling the incorporation of a 6-carbon spacer with a photolabile group into DNA or RNA strands. This reagent allows for the controlled release of oligonucleotides or modifications upon UV irradiation (e.g., 365 nm light), facilitating applications such as photocleavable probes, reversible immobilization, or triggered drug delivery systems. The C6 spacer provides a hydrophobic linker to distance functional groups from the oligonucleotide backbone, reducing steric hindrance and minimizing unwanted interactions.

CAT: BRP-02678

Molecular Formula: C45H57N4O8P

Molecular Weight: 812.94

Purity: ≥97%

Appearance: Light yellow solid

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InChIKey: MUZBYWATPDTSPR-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OC(C1=CC(CNC(CCCCCOC(C2=CC=C(OC)C=C2)(C3=CC=C(OC)C=C3)C4=CC=CC=C4)=O)=CC=C1[N+]([O-])=O)C)OCCC#N)C

IUPAC Name: 1-(5-((6-(bis(4-methoxyphenyl)(phenyl)methoxy)hexanamido)methyl)-2-nitrophenyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H57N4O8P/c1-33(2)48(34(3)4)58(56-30-14-28-46)57-35(5)42-31-36(18-27-43(42)49(51)52)32-47-44(50)17-12-9-13-29-55-45(37-15-10-8-11-16-37,38-19-23-40(53-6)24-20-38)39-21-25-41(54-7)26-22-39/h8,10-11,15-16,18-27,31,33-35H,9,12-14,17,29-30,32H2,1-7H3,(H,47,50)

Synonyms: PC Spacer C6 Phosphoramidite

2'-F-rG(N-Ac) CE Phosphoramidite

Description: 2'-F-rG(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-fluoro-modified riboguanosine (rG) with an N-acetyl protecting group. This modification enhances nuclease resistance and improves hybridization affinity compared to unmodified RNA, making it ideal for applications in antisense oligonucleotides, siRNA, and aptamers.

CAT: BRP-02679

Molecular Formula: C42H49FN7O8P

Molecular Weight: 829.87

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: SHQZYHATOYAOCM-ZEONBSCYSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(NC(C)=O)=N6)=O)[C@H](F)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H49FN7O8P/c1-26(2)50(27(3)4)59(56-23-11-22-44)58-37-34(57-40(35(37)43)49-25-45-36-38(49)47-41(46-28(5)51)48-39(36)52)24-55-42(29-12-9-8-10-13-29,30-14-18-32(53-6)19-15-30)31-16-20-33(54-7)21-17-31/h8-10,12-21,25-27,34-35,37,40H,11,23-24H2,1-7H3,(H2,46,47,48,51,52)/t34-,35-,37-,40-,59?/m1/s1

Synonyms: 2'-F-rG(N-Ac) Phosphoramidite; 5'-O-DMT-2'-fluoro-N2-acetyl-2'-Deoxy-guanosine 3'-CE phosphoramidite; 2'-Deoxy-5'-O-DMT-2'-fluoro-N2-acetyl 3'-CE phosphoramidite; 2'-F-Ac-G-CEP; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-acetyl-Guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; DMT-2'Fluoro-dG(Ac) Phosphoramidite; 2'-F-dG(Ac) 3'-CE phosphoramidite; DMT-2'-F-dG(Ac)-CE Phosphoramidite; 2'-F-dG(Ac)-CE Phosphoramidite; 2'-Fluoro-N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine-3'-CE-Phosphoramidite; 2'-F-dG(Ac) CE Phosphoramidite

2'-F-ANA-rG(N-Ac) CE Phosphoramidite

Description: 2'-F-ANA-rG(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-fluoroarabinonucleic acid (2'-F-ANA) modification into RNA strands. The 2'-F-ANA modification enhances nuclease resistance and improves hybridization affinity compared to unmodified RNA, making it ideal for applications in antisense oligonucleotides, siRNA, and aptamers.

CAT: BRP-02680

Molecular Formula: C42H49FN7O8P

Molecular Weight: 829.87

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: SHQZYHATOYAOCM-RXHHJYBUSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(NC(C)=O)=N6)=O)[C@@H](F)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4S,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

Synonyms: 2'-F-ANA-rG(N-Ac) Phosphoramidite; 9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-acetyl 3'-CE phosphoramidite; 5'-O-DMT-2'-fluoro-N2-acetyl-2'-arabinofuranosyl-deoxyguanosine 3'-CE phosphoramidite; 2'-F-2'-ara-N2-Ac-dG phosphoramidite; N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-fluoro-2'-arabinoguanosine-3'-CED-phosphoramidite; 9-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl}-2-(acetylamino)-1,9-dihydro-6H-purin-6-one; 2'-F-ANA-dG(Ac) CE Phosphoramidite

2'-MOE-rG(N-Ac) CE Phosphoramidite

Description: 2'-MOE-rG(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methoxyethyl (2'-MOE) group into riboguanosine (rG). The N-acetyl protecting group ensures stability during synthesis. This modification enhances nuclease resistance and improves pharmacokinetic properties, making it ideal for antisense oligonucleotides and siRNA applications.

CAT: BRP-02681

Molecular Formula: C45H56N7O10P

Molecular Weight: 885.96

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: PNZHKXYCIULQJO-DSOQZZHISA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(NC(C)=O)=N6)=O)[C@H](OCCOC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H56N7O10P/c1-29(2)52(30(3)4)63(60-24-12-23-46)62-39-37(61-43(40(39)58-26-25-55-6)51-28-47-38-41(51)49-44(48-31(5)53)50-42(38)54)27-59-45(32-13-10-9-11-14-32,33-15-19-35(56-7)20-16-33)34-17-21-36(57-8)22-18-34/h9-11,13-22,28-30,37,39-40,43H,12,24-27H2,1-8H3,(H2,48,49,50,53,54)/t37-,39-,40-,43-,63?/m1/s1

Synonyms: 2'-MOE-rG(N-Ac) Phosphoramidite; 2'-MOE-G(Ac) Phosphoramidite; 2'-MOE-G(Ac) 3'-CE-Phosphoramidite; 2'-O-MOE-rG(N-Ac) CE Phosphoramidite; 5'-O-DMT-N2-acetyl-2'-O-methoxyethylguanosine 3'-CE phosphoramidite; 5'-O-DMTr-N2-Ac-2'-O-MOE-guanosine-3'-CED phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-acetyl-2'-O-(2-methoxyethyl)guanosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 2'-MOE-G(Ac)-3'-phosphoramidite; N2-Acetyl-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite; N-Acetyl-2'-O-(2-methoxyethyl)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)guanosine; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-N-Acetyl-2'-O-(2-methoxyethyl)guanosine

2'-OMe-VPTm CE Phosphoramidite

Description: 2'-OMe-VPTm CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methyl (2'-OMe) modified uridine with a 5'-vinyl phosphonate (VP) moiety. The VP group mimics the natural 5'-phosphate, enhancing metabolic stability and RISC recognition in siRNA applications, while the 2'-OMe modification improves nuclease resistance and hybridization properties.

CAT: BRP-02682

Molecular Formula: C25H42N4O9P2

Molecular Weight: 604.58

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: PYHMWMHPGVMZAA-QTTIFAQWSA-N

CanonicalSMILES: CO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCC)(OCC)=O)O[C@H]1N2C(NC(C(C)=C2)=O)=O

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-2-((E)-2-(diethoxyphosphoryl)vinyl)-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C25H42N4O9P2/c1-9-35-40(32,36-10-2)15-12-20-21(38-39(34-14-11-13-26)29(17(3)4)18(5)6)22(33-8)24(37-20)28-16-19(7)23(30)27-25(28)31/h12,15-18,20-22,24H,9-11,14H2,1-8H3,(H,27,30,31)/b15-12+/t20-,21-,22-,24-,39?/m1/s1

Synonyms: 2'-OMe-VPTm Phosphoramidite; 5'-O-ethyl-Vinyl Phosphonate, 2'-OMe-T CE-Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]thymine; 5'-Et-(E)-vinyl phosphonate-2'-O-Me-T-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-rT-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-5-Me-rU-3'-CE-Phosphoramidite

2'-OMe-VPAm(N-Bz) CE Phosphoramidite

Description: 2'-OMe-VPAm(N-Bz) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methyl (2'-OMe) adenosine with a 5'-vinyl phosphonate (VP) moiety and N-benzoyl (N-Bz) protection. The VP group mimics the natural 5'-phosphate, enhancing metabolic stability and RISC recognition in siRNA applications, while the 2'-OMe modification improves nuclease resistance and hybridization properties.

CAT: BRP-02683

Molecular Formula: C32H45N7O8P2

Molecular Weight: 717.70

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: XHLFAYWBCXEQGR-DLZQRPHASA-N

CanonicalSMILES: CO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCC)(OCC)=O)O[C@H]1N(C=N2)C3=C2C(NC(C4=CC=CC=C4)=O)=NC=N3

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((E)-2-(diethoxyphosphoryl)vinyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C32H45N7O8P2/c1-8-44-49(41,45-9-2)19-16-25-27(47-48(43-18-13-17-33)39(22(3)4)23(5)6)28(42-7)32(46-25)38-21-36-26-29(34-20-35-30(26)38)37-31(40)24-14-11-10-12-15-24/h10-12,14-16,19-23,25,27-28,32H,8-9,13,18H2,1-7H3,(H,34,35,37,40)/b19-16+/t25-,27-,28-,32-,48?/m1/s1

Synonyms: 2'-OMe-VPAm(N-Bz) Phosphoramidite; 5'-Et-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylmino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(dimethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N6-benzoyladenosine

2'-OMe-VPCm(N-Ac) CE Phosphoramidite

Description: 2'-OMe-VPCm(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methyl (2'-OMe) modified cytidine with a 5'-vinyl phosphonate (VP) moiety and N-acetyl protection. The VP group mimics the natural 5'-phosphate, enhancing metabolic stability and RISC recognition in siRNA applications, while the 2'-OMe modification improves nuclease resistance and hybridization properties.

CAT: BRP-02684

Molecular Formula: C26H43N5O9P2

Molecular Weight: 631.60

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: HHPNEVDKWIAOGT-IVXGJCLLSA-N

CanonicalSMILES: CO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCC)(OCC)=O)O[C@H]1N2C(N=C(NC(C)=O)C=C2)=O

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((E)-2-(diethoxyphosphoryl)vinyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C26H43N5O9P2/c1-9-37-42(34,38-10-2)17-13-21-23(40-41(36-16-11-14-27)31(18(3)4)19(5)6)24(35-8)25(39-21)30-15-12-22(28-20(7)32)29-26(30)33/h12-13,15,17-19,21,23-25H,9-11,16H2,1-8H3,(H,28,29,32,33)/b17-13+/t21-,23-,24-,25-,41?/m1/s1

Synonyms: 2'-OMe-VPCm(N-Ac) Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N-acetylcytosine; 5'-Et-(E)-vinyl phosphonate-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite

2'-OMe-VPGm(N-dmf) CE Phosphoramidite

Description: 2'-OMe-VPGm(N-dmf) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methyl (2'-OMe) guanosine with a 5'-vinyl phosphonate (VP) moiety and N-dimethylformamidine (N-dmf) protection. The VP group mimics the natural 5'-phosphate, enhancing metabolic stability and RISC recognition in siRNA applications, while the 2'-OMe modification improves nuclease resistance and hybridization properties.

CAT: BRP-02685

Molecular Formula: C28H46N8O8P2

Molecular Weight: 684.67

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: BVSWPHWCQRVZNF-VMRKIFRRSA-N

CanonicalSMILES: CO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCC)(OCC)=O)O[C@H]1N(C=N2)C3=C2C(NC(N=CN(C)C)=N3)=O

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-2-((E)-2-(diethoxyphosphoryl)vinyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C28H46N8O8P2/c1-10-41-46(38,42-11-2)16-13-21-23(44-45(40-15-12-14-29)36(19(3)4)20(5)6)24(39-9)27(43-21)35-18-30-22-25(35)32-28(33-26(22)37)31-17-34(7)8/h13,16-21,23-24,27H,10-12,15H2,1-9H3,(H,32,33,37)/b16-13+,31-17?/t21-,23-,24-,27-,45?/m1/s1

Synonyms: 2'-OMe-VPGm(N-dmf) Phosphoramidite; 5'-Et-(E)-vinyl phosphonate-2'-O-Me-rG(DMF)-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-rG(DMF)-3'-CE-Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylmino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(dimethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N2-dimethylformamidine-guanine

GNA-(S)-G(N-Ac) CE Phosphoramidite

Description: GNA-(S)-G(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a glycol nucleic acid (GNA) monomer with an N-acetyl protecting group. GNA is a synthetic nucleic acid analog that forms stable duplexes with complementary DNA or RNA, offering unique structural properties for applications in antisense oligonucleotides, siRNA, and aptamers.

CAT: BRP-02686

CAS: 3036240-74-8

Molecular Formula: C40H48N7O7P

Molecular Weight: 769.84

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: BMIVENSLSRTDAL-DBULTYROSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H](CN4C(N=C(NC(C)=O)NC5=O)=C5N=C4)OP(OCCC#N)N(C(C)C)C(C)C

IUPAC Name: (S)-1-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C40H48N7O7P/c1-27(2)47(28(3)4)55(53-23-11-22-41)54-35(24-46-26-42-36-37(46)44-39(43-29(5)48)45-38(36)49)25-52-40(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-21,26-28,35H,11,23-25H2,1-7H3,(H2,43,44,45,48,49)/t35-,55?/m0/s1

Synonyms: GNA-(S)-G(N-Ac) Phosphoramidite; Ac-G-(S)-GNA phosphoramidite; 2'-O-(2-Cyanoethoxy)(diisopropylamino)phosphino-3'-O-(4,4'-dimethoxytriphenyl)methyl-N2-acetyl-(S)-9-(2,3-dihydroxypropyl)guanine; (S)-GNA-G(Ac) phosphoramidite; DMT-G(Ac)-(S)-GNA Phosphoramidite; GNA-(S)-G(Ac) CE Phosphoramidite

UNA-G(N-dmf) CE Phosphoramidite

Description: UNA-G(N-dmf) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of an unlocked nucleic acid (UNA) monomer with an N-dimethylformamidine (N-dmf) protecting group. UNA is a synthetic nucleic acid analog that lacks the C2'-C3' bond in the ribose ring, resulting in a flexible structure that destabilizes duplexes and enhances nuclease resistance. This makes it ideal for applications in antisense oligonucleotides, siRNA, and aptamers where controlled hybridization and stability are crucial.

CAT: BRP-02687

Molecular Formula: C50H59N8O9P

Molecular Weight: 947.04

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: BZLUAMNXTXJONM-UGQOJQRVSA-N

CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H](COP(OCCC#N)N(C(C)C)C(C)C)O[C@@H](N4C(N=C(N=CN(C)C)NC5=O)=C5N=C4)COC(C6=CC=CC=C6)=O

IUPAC Name: (2R)-2-(((2R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propan-2-yl)oxy)-2-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl benzoate

InChI: InChI=1S/C50H59N8O9P/c1-35(2)58(36(3)4)68(65-29-15-28-51)66-31-43(30-64-50(38-18-13-10-14-19-38,39-20-24-41(61-7)25-21-39)40-22-26-42(62-8)27-23-40)67-44(32-63-48(60)37-16-11-9-12-17-37)57-34-52-45-46(57)54-49(55-47(45)59)53-33-56(5)6/h9-14,16-27,33-36,43-44H,15,29-32H2,1-8H3,(H,54,55,59)/t43-,44-,68?/m1/s1

Synonyms: UNA-G(N-dmf) Phosphoramidite; UNA-G(DMF)-CE Phosphoramidite; N2-Dimethylformamidine-(5'-(4,4'-dimethoxytrityl)-2'-benzoyl-2',3'-seco-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; UNA-G(DMF) 3'-CE Phosphoramidite

TAO-G CE Phosphoramdite

Endo BCN-PEG3 CE Phosphoramidite

Amino-Modifier C3 CE Phosphoramidite

HPro CE Phosphoramidite

Spermine CE Phosphoramidite (unprotected)

DNP CE Phosphoramidite

Desthiobiotin(N-BB) TEG CE Phosphoramidite

Biotin(N-BB) TEG CE Phosphoramidite

PC Spacer C6 CE Phosphoramidite

2'-F-rG(N-Ac) CE Phosphoramidite

2'-F-ANA-rG(N-Ac) CE Phosphoramidite

2'-MOE-rG(N-Ac) CE Phosphoramidite

2'-OMe-VPTm CE Phosphoramidite

2'-OMe-VPAm(N-Bz) CE Phosphoramidite

2'-OMe-VPCm(N-Ac) CE Phosphoramidite

2'-OMe-VPGm(N-dmf) CE Phosphoramidite

GNA-(S)-G(N-Ac) CE Phosphoramidite

UNA-G(N-dmf) CE Phosphoramidite

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