What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

PC Spacer C6 CE Phosphoramidite

Description: PC Spacer C6 CE Phosphoramidite is a photocleavable spacer phosphoramidite designed for solid-phase oligonucleotide synthesis, enabling the incorporation of a 6-carbon spacer with a photolabile group into DNA or RNA strands. This reagent allows for the controlled release of oligonucleotides or modifications upon UV irradiation (e.g., 365 nm light), facilitating applications such as photocleavable probes, reversible immobilization, or triggered drug delivery systems. The C6 spacer provides a hydrophobic linker to distance functional groups from the oligonucleotide backbone, reducing steric hindrance and minimizing unwanted interactions.

CAT: BRP-02678

Molecular Formula: C45H57N4O8P

Molecular Weight: 812.94

Purity: ≥97%

Appearance: Light yellow solid

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InChIKey: MUZBYWATPDTSPR-UHFFFAOYSA-N

SMILES: CC(N(C(C)C)P(OC(C1=CC(CNC(CCCCCOC(C2=CC=C(OC)C=C2)(C3=CC=C(OC)C=C3)C4=CC=CC=C4)=O)=CC=C1[N+]([O-])=O)C)OCCC#N)C

IUPAC Name: 1-(5-((6-(bis(4-methoxyphenyl)(phenyl)methoxy)hexanamido)methyl)-2-nitrophenyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H57N4O8P/c1-33(2)48(34(3)4)58(56-30-14-28-46)57-35(5)42-31-36(18-27-43(42)49(51)52)32-47-44(50)17-12-9-13-29-55-45(37-15-10-8-11-16-37,38-19-23-40(53-6)24-20-38)39-21-25-41(54-7)26-22-39/h8,10-11,15-16,18-27,31,33-35H,9,12-14,17,29-30,32H2,1-7H3,(H,47,50)

Synonyms: PC Spacer C6 Phosphoramidite

2'-F-rG(N-Ac) CE Phosphoramidite

Description: 2'-F-rG(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-fluoro-modified riboguanosine (rG) with an N-acetyl protecting group. This modification enhances nuclease resistance and improves hybridization affinity compared to unmodified RNA, making it ideal for applications in antisense oligonucleotides, siRNA, and aptamers.

CAT: BRP-02679

Molecular Formula: C42H49FN7O8P

Molecular Weight: 829.87

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: SHQZYHATOYAOCM-ZEONBSCYSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(NC(C)=O)=N6)=O)[C@H](F)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H49FN7O8P/c1-26(2)50(27(3)4)59(56-23-11-22-44)58-37-34(57-40(35(37)43)49-25-45-36-38(49)47-41(46-28(5)51)48-39(36)52)24-55-42(29-12-9-8-10-13-29,30-14-18-32(53-6)19-15-30)31-16-20-33(54-7)21-17-31/h8-10,12-21,25-27,34-35,37,40H,11,23-24H2,1-7H3,(H2,46,47,48,51,52)/t34-,35-,37-,40-,59?/m1/s1

Synonyms: 2'-F-rG(N-Ac) Phosphoramidite; 5'-O-DMT-2'-fluoro-N2-acetyl-2'-Deoxy-guanosine 3'-CE phosphoramidite; 2'-Deoxy-5'-O-DMT-2'-fluoro-N2-acetyl 3'-CE phosphoramidite; 2'-F-Ac-G-CEP; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-acetyl-Guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; DMT-2'Fluoro-dG(Ac) Phosphoramidite; 2'-F-dG(Ac) 3'-CE phosphoramidite; DMT-2'-F-dG(Ac)-CE Phosphoramidite; 2'-F-dG(Ac)-CE Phosphoramidite; 2'-Fluoro-N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine-3'-CE-Phosphoramidite; 2'-F-dG(Ac) CE Phosphoramidite

2'-F-ANA-rG(N-Ac) CE Phosphoramidite

Description: 2'-F-ANA-rG(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-fluoroarabinonucleic acid (2'-F-ANA) modification into RNA strands. The 2'-F-ANA modification enhances nuclease resistance and improves hybridization affinity compared to unmodified RNA, making it ideal for applications in antisense oligonucleotides, siRNA, and aptamers.

CAT: BRP-02680

Molecular Formula: C42H49FN7O8P

Molecular Weight: 829.87

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: SHQZYHATOYAOCM-RXHHJYBUSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(NC(C)=O)=N6)=O)[C@@H](F)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4S,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

Synonyms: 2'-F-ANA-rG(N-Ac) Phosphoramidite; 9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-acetyl 3'-CE phosphoramidite; 5'-O-DMT-2'-fluoro-N2-acetyl-2'-arabinofuranosyl-deoxyguanosine 3'-CE phosphoramidite; 2'-F-2'-ara-N2-Ac-dG phosphoramidite; N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-fluoro-2'-arabinoguanosine-3'-CED-phosphoramidite; 9-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl}-2-(acetylamino)-1,9-dihydro-6H-purin-6-one; 2'-F-ANA-dG(Ac) CE Phosphoramidite

2'-MOE-rG(N-Ac) CE Phosphoramidite

Description: 2'-MOE-rG(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methoxyethyl (2'-MOE) group into riboguanosine (rG). The N-acetyl protecting group ensures stability during synthesis. This modification enhances nuclease resistance and improves pharmacokinetic properties, making it ideal for antisense oligonucleotides and siRNA applications.

CAT: BRP-02681

Molecular Formula: C45H56N7O10P

Molecular Weight: 885.96

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: PNZHKXYCIULQJO-DSOQZZHISA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(NC(C)=O)=N6)=O)[C@H](OCCOC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H56N7O10P/c1-29(2)52(30(3)4)63(60-24-12-23-46)62-39-37(61-43(40(39)58-26-25-55-6)51-28-47-38-41(51)49-44(48-31(5)53)50-42(38)54)27-59-45(32-13-10-9-11-14-32,33-15-19-35(56-7)20-16-33)34-17-21-36(57-8)22-18-34/h9-11,13-22,28-30,37,39-40,43H,12,24-27H2,1-8H3,(H2,48,49,50,53,54)/t37-,39-,40-,43-,63?/m1/s1

Synonyms: 2'-MOE-rG(N-Ac) Phosphoramidite; 2'-MOE-G(Ac) Phosphoramidite; 2'-MOE-G(Ac) 3'-CE-Phosphoramidite; 2'-O-MOE-rG(N-Ac) CE Phosphoramidite; 5'-O-DMT-N2-acetyl-2'-O-methoxyethylguanosine 3'-CE phosphoramidite; 5'-O-DMTr-N2-Ac-2'-O-MOE-guanosine-3'-CED phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-acetyl-2'-O-(2-methoxyethyl)guanosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 2'-MOE-G(Ac)-3'-phosphoramidite; N2-Acetyl-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite; N-Acetyl-2'-O-(2-methoxyethyl)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)guanosine; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-N-Acetyl-2'-O-(2-methoxyethyl)guanosine

2'-OMe-VPTm CE Phosphoramidite

Description: 2'-OMe-VPTm CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methyl (2'-OMe) modified uridine with a 5'-vinyl phosphonate (VP) moiety. The VP group mimics the natural 5'-phosphate, enhancing metabolic stability and RISC recognition in siRNA applications, while the 2'-OMe modification improves nuclease resistance and hybridization properties.

CAT: BRP-02682

Molecular Formula: C25H42N4O9P2

Molecular Weight: 604.58

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: PYHMWMHPGVMZAA-QTTIFAQWSA-N

SMILES: CO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCC)(OCC)=O)O[C@H]1N2C(NC(C(C)=C2)=O)=O

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-2-((E)-2-(diethoxyphosphoryl)vinyl)-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C25H42N4O9P2/c1-9-35-40(32,36-10-2)15-12-20-21(38-39(34-14-11-13-26)29(17(3)4)18(5)6)22(33-8)24(37-20)28-16-19(7)23(30)27-25(28)31/h12,15-18,20-22,24H,9-11,14H2,1-8H3,(H,27,30,31)/b15-12+/t20-,21-,22-,24-,39?/m1/s1

Synonyms: 2'-OMe-VPTm Phosphoramidite; 5'-O-ethyl-Vinyl Phosphonate, 2'-OMe-T CE-Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]thymine; 5'-Et-(E)-vinyl phosphonate-2'-O-Me-T-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-rT-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-5-Me-rU-3'-CE-Phosphoramidite

2'-OMe-VPAm(N-Bz) CE Phosphoramidite

Description: 2'-OMe-VPAm(N-Bz) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methyl (2'-OMe) adenosine with a 5'-vinyl phosphonate (VP) moiety and N-benzoyl (N-Bz) protection. The VP group mimics the natural 5'-phosphate, enhancing metabolic stability and RISC recognition in siRNA applications, while the 2'-OMe modification improves nuclease resistance and hybridization properties.

CAT: BRP-02683

Molecular Formula: C32H45N7O8P2

Molecular Weight: 717.70

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: XHLFAYWBCXEQGR-DLZQRPHASA-N

SMILES: CO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCC)(OCC)=O)O[C@H]1N(C=N2)C3=C2C(NC(C4=CC=CC=C4)=O)=NC=N3

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((E)-2-(diethoxyphosphoryl)vinyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C32H45N7O8P2/c1-8-44-49(41,45-9-2)19-16-25-27(47-48(43-18-13-17-33)39(22(3)4)23(5)6)28(42-7)32(46-25)38-21-36-26-29(34-20-35-30(26)38)37-31(40)24-14-11-10-12-15-24/h10-12,14-16,19-23,25,27-28,32H,8-9,13,18H2,1-7H3,(H,34,35,37,40)/b19-16+/t25-,27-,28-,32-,48?/m1/s1

Synonyms: 2'-OMe-VPAm(N-Bz) Phosphoramidite; 5'-Et-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylmino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(dimethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N6-benzoyladenosine

2'-OMe-VPCm(N-Ac) CE Phosphoramidite

Description: 2'-OMe-VPCm(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methyl (2'-OMe) modified cytidine with a 5'-vinyl phosphonate (VP) moiety and N-acetyl protection. The VP group mimics the natural 5'-phosphate, enhancing metabolic stability and RISC recognition in siRNA applications, while the 2'-OMe modification improves nuclease resistance and hybridization properties.

CAT: BRP-02684

Molecular Formula: C26H43N5O9P2

Molecular Weight: 631.60

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: HHPNEVDKWIAOGT-IVXGJCLLSA-N

SMILES: CO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCC)(OCC)=O)O[C@H]1N2C(N=C(NC(C)=O)C=C2)=O

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((E)-2-(diethoxyphosphoryl)vinyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C26H43N5O9P2/c1-9-37-42(34,38-10-2)17-13-21-23(40-41(36-16-11-14-27)31(18(3)4)19(5)6)24(35-8)25(39-21)30-15-12-22(28-20(7)32)29-26(30)33/h12-13,15,17-19,21,23-25H,9-11,16H2,1-8H3,(H,28,29,32,33)/b17-13+/t21-,23-,24-,25-,41?/m1/s1

Synonyms: 2'-OMe-VPCm(N-Ac) Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N-acetylcytosine; 5'-Et-(E)-vinyl phosphonate-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite

2'-OMe-VPGm(N-dmf) CE Phosphoramidite

Description: 2'-OMe-VPGm(N-dmf) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a 2'-O-methyl (2'-OMe) guanosine with a 5'-vinyl phosphonate (VP) moiety and N-dimethylformamidine (N-dmf) protection. The VP group mimics the natural 5'-phosphate, enhancing metabolic stability and RISC recognition in siRNA applications, while the 2'-OMe modification improves nuclease resistance and hybridization properties.

CAT: BRP-02685

Molecular Formula: C28H46N8O8P2

Molecular Weight: 684.67

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: BVSWPHWCQRVZNF-VMRKIFRRSA-N

SMILES: CO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCC)(OCC)=O)O[C@H]1N(C=N2)C3=C2C(NC(N=CN(C)C)=N3)=O

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-2-((E)-2-(diethoxyphosphoryl)vinyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C28H46N8O8P2/c1-10-41-46(38,42-11-2)16-13-21-23(44-45(40-15-12-14-29)36(19(3)4)20(5)6)24(39-9)27(43-21)35-18-30-22-25(35)32-28(33-26(22)37)31-17-34(7)8/h13,16-21,23-24,27H,10-12,15H2,1-9H3,(H,32,33,37)/b16-13+,31-17?/t21-,23-,24-,27-,45?/m1/s1

Synonyms: 2'-OMe-VPGm(N-dmf) Phosphoramidite; 5'-Et-(E)-vinyl phosphonate-2'-O-Me-rG(DMF)-3'-CE-Phosphoramidite; 5'-Ethyl-(E)-vinyl phosphonate-2'-O-Me-rG(DMF)-3'-CE-Phosphoramidite; 1-[(5E)-3-O-[(Bis-diisopropylmino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(dimethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N2-dimethylformamidine-guanine

GNA-(S)-G(N-Ac) CE Phosphoramidite

Description: GNA-(S)-G(N-Ac) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of a glycol nucleic acid (GNA) monomer with an N-acetyl protecting group. GNA is a synthetic nucleic acid analog that forms stable duplexes with complementary DNA or RNA, offering unique structural properties for applications in antisense oligonucleotides, siRNA, and aptamers.

CAT: BRP-02686

CAS: 3036240-74-8

Molecular Formula: C40H48N7O7P

Molecular Weight: 769.84

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: BMIVENSLSRTDAL-DBULTYROSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H](CN4C(N=C(NC(C)=O)NC5=O)=C5N=C4)OP(OCCC#N)N(C(C)C)C(C)C

IUPAC Name: (S)-1-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C40H48N7O7P/c1-27(2)47(28(3)4)55(53-23-11-22-41)54-35(24-46-26-42-36-37(46)44-39(43-29(5)48)45-38(36)49)25-52-40(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-21,26-28,35H,11,23-25H2,1-7H3,(H2,43,44,45,48,49)/t35-,55?/m0/s1

Synonyms: GNA-(S)-G(N-Ac) Phosphoramidite; Ac-G-(S)-GNA phosphoramidite; 2'-O-(2-Cyanoethoxy)(diisopropylamino)phosphino-3'-O-(4,4'-dimethoxytriphenyl)methyl-N2-acetyl-(S)-9-(2,3-dihydroxypropyl)guanine; (S)-GNA-G(Ac) phosphoramidite; DMT-G(Ac)-(S)-GNA Phosphoramidite; GNA-(S)-G(Ac) CE Phosphoramidite

UNA-G(N-dmf) CE Phosphoramidite

Description: UNA-G(N-dmf) CE Phosphoramidite is a modified phosphoramidite reagent designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of an unlocked nucleic acid (UNA) monomer with an N-dimethylformamidine (N-dmf) protecting group. UNA is a synthetic nucleic acid analog that lacks the C2'-C3' bond in the ribose ring, resulting in a flexible structure that destabilizes duplexes and enhances nuclease resistance. This makes it ideal for applications in antisense oligonucleotides, siRNA, and aptamers where controlled hybridization and stability are crucial.

CAT: BRP-02687

Molecular Formula: C50H59N8O9P

Molecular Weight: 947.04

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: BZLUAMNXTXJONM-UGQOJQRVSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H](COP(OCCC#N)N(C(C)C)C(C)C)O[C@@H](N4C(N=C(N=CN(C)C)NC5=O)=C5N=C4)COC(C6=CC=CC=C6)=O

IUPAC Name: (2R)-2-(((2R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propan-2-yl)oxy)-2-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl benzoate

InChI: InChI=1S/C50H59N8O9P/c1-35(2)58(36(3)4)68(65-29-15-28-51)66-31-43(30-64-50(38-18-13-10-14-19-38,39-20-24-41(61-7)25-21-39)40-22-26-42(62-8)27-23-40)67-44(32-63-48(60)37-16-11-9-12-17-37)57-34-52-45-46(57)54-49(55-47(45)59)53-33-56(5)6/h9-14,16-27,33-36,43-44H,15,29-32H2,1-8H3,(H,54,55,59)/t43-,44-,68?/m1/s1

Synonyms: UNA-G(N-dmf) Phosphoramidite; UNA-G(DMF)-CE Phosphoramidite; N2-Dimethylformamidine-(5'-(4,4'-dimethoxytrityl)-2'-benzoyl-2',3'-seco-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; UNA-G(DMF) 3'-CE Phosphoramidite

CN-LNA-A(Bz)-CE Phosphoramidite

Description: CN-LNA-A(Bz)-CE Phosphoramidite is a phosphoramidite building block used in solid-phase oligonucleotide synthesis, based on a Locked Nucleic Acid (LNA) scaffold where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge to enhance thermal stability and binding affinity. It features adenine as the nucleobase with a benzoyl (Bz) protecting group, a 5'-dimethoxytrityl (DMTr) protecting group, and a 3'-cyanoethyl (CE) phosphoramidite functionality for stepwise incorporation. It inherits the high efficiency of the LNA series modifications while offering improved hydrophilicity and lower toxicity. This reagent is widely employed in the preparation of modified oligonucleotides such as antisense strands, siRNAs, and molecular probes to improve nuclease resistance, hybridization strength, and overall therapeutic or diagnostic performance.

CAT: BRP-02697

Molecular Formula: C49H51N8O8P

Molecular Weight: 910.97

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InChIKey: NEJNPVBGYQLRKW-IRRNRTHASA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@]4(O5)[C@H]([C@H]([C@@H]5N6C(N=CN=C7NC(C8=CC=CC=C8)=O)=C7N=C6)O[C@H]4C#N)OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C49H51N8O8P/c1-32(2)57(33(3)4)66(62-27-13-26-50)65-43-42-47(56-31-54-41-44(52-30-53-45(41)56)55-46(58)34-14-9-7-10-15-34)64-48(43,40(28-51)63-42)29-61-49(35-16-11-8-12-17-35,36-18-22-38(59-5)23-19-36)37-20-24-39(60-6)25-21-37/h7-12,14-25,30-33,40,42-43,47H,13,27,29H2,1-6H3,(H,52,53,55,58)/t40-,42+,43-,47+,48-,66?/m0/s1

Synonyms: (1S,3R,4R,6S,7S)-3-(6-Benzamido-9H-purin-9-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-cyano-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-ODMT CN-LNA N-Bz A Phosphoramidite (Amidite); CN-LNA-A(Bz) phosphoramidite; 5'-ODMT CN-LNA A(Bz) Phosphoramidite; CN-LNA-A(Bz) amidite

CN-LNA-MeC(Bz)-CE Phosphoramidite

Description: CN-LNA-MeC(Bz)-CE Phosphoramidite is a phosphoramidite building block for solid-phase oligonucleotide synthesis, based on a Locked Nucleic Acid (LNA) scaffold in which the ribose ring is conformationally constrained by a 2'-O to 4'-C methylene bridge, resulting in enhanced duplex stability and stronger hybridization affinity. The nucleobase is 5-methylcytidine (MeC), protected with a benzoyl (Bz) group, while the 5'-hydroxyl is safeguarded with a dimethoxytrityl (DMTr) group and the 3'-position carries a cyanoethyl (CE) phosphoramidite function for efficient coupling. It inherits the high efficiency of LNA modifications while offering improved hydrophilicity and lower toxicity. This phosphoramidite is widely applied in the synthesis of modified oligonucleotides such as antisense strands, siRNAs, and molecular probes, enhancing nuclease resistance, hybridization strength, and overall performance in therapeutic and diagnostic applications.

CAT: BRP-02698

Molecular Formula: C49H53N6O9P

Molecular Weight: 900.97

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InChIKey: HXCUQIISDWQYAJ-IXCBJNTGSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@]4(O5)[C@H]([C@H]([C@@H]5N6C=C(C)C(NC(C7=CC=CC=C7)=O)=NC6=O)O[C@H]4C#N)OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C49H53N6O9P/c1-32(2)55(33(3)4)65(61-28-14-27-50)64-43-42-46(54-30-34(5)44(53-47(54)57)52-45(56)35-15-10-8-11-16-35)63-48(43,41(29-51)62-42)31-60-49(36-17-12-9-13-18-36,37-19-23-39(58-6)24-20-37)38-21-25-40(59-7)26-22-38/h8-13,15-26,30,32-33,41-43,46H,14,28,31H2,1-7H3,(H,52,53,56,57)/t41-,42+,43-,46+,48-,65?/m0/s1

Synonyms: (1S,3R,4R,6S,7S)-3-(4-Benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-cyano-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-ODMT CN-LNA N-Bzm5C Phosphoramidite (Amidite); 5'-ODMT CN-LNA N-Bz 5-Me C Phosphoramidite; CN-LNA-5-Me-C(Bz) Phosphoramidite

CN-LNA-G(iBu)-CE Phosphoramidite

Description: CN-LNA-G(iBu)-CE Phosphoramidite is a phosphoramidite building block designed for solid-phase oligonucleotide synthesis, incorporating a Locked Nucleic Acid (LNA) scaffold where the ribose ring is constrained by a 2'-O to 4'-C methylene bridge to enhance duplex stability and hybridization affinity. It contains guanine as the nucleobase, protected with an isobutyryl (iBu) group, along with a 5'-dimethoxytrityl (DMTr) protecting group and a 3'-cyanoethyl (CE) phosphoramidite moiety for controlled stepwise coupling. It inherits the high efficiency of the LNA series modifications while offering improved hydrophilicity and lower toxicity. This phosphoramidite is applied in the synthesis of modified oligonucleotides such as antisense molecules, siRNAs, and diagnostic probes, providing enhanced nuclease resistance, stronger binding to complementary sequences, and improved performance in therapeutic and molecular biology applications.

CAT: BRP-02699

Molecular Formula: C46H53N8O9P

Molecular Weight: 892.95

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InChIKey: HDFVVMUPRQZFAG-XBTUEPHFSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@]4(O5)[C@H]([C@H]([C@@H]5N6C(N=C(NC(C(C)C)=O)NC7=O)=C7N=C6)O[C@H]4C#N)OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C46H53N8O9P/c1-28(2)41(55)51-44-50-40-37(42(56)52-44)49-27-53(40)43-38-39(63-64(60-24-12-23-47)54(29(3)4)30(5)6)45(62-43,36(25-48)61-38)26-59-46(31-13-10-9-11-14-31,32-15-19-34(57-7)20-16-32)33-17-21-35(58-8)22-18-33/h9-11,13-22,27-30,36,38-39,43H,12,24,26H2,1-8H3,(H2,50,51,52,55,56)/t36-,38+,39-,43+,45-,64?/m0/s1

Synonyms: (1S,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-cyano-3-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-ODMT CN-LNA G(iBu) Phosphoramidite (Amidite); N2-ibu-G-(S)-cEt-Phosphoramidite; CN-LNA-G(iBu) phosphoramidite; CN-LNA-rG(ibu) Phosphoramidite; CN-LNA-G(iBu)-3'-CE-Phosphoramidite; CN-LNA-G(iBu) amidite

CN-LNA-5-MeU-CE Phosphoramidite

Description: CN-LNA-5-MeU-CE Phosphoramidite is a phosphoramidite building block used in solid-phase oligonucleotide synthesis, featuring a Locked Nucleic Acid (LNA) framework where the ribose ring is locked by a 2'-O to 4'-C methylene bridge to enhance duplex stability and binding affinity. Its nucleobase is 5-methyluridine (5-MeU), providing improved base stacking and additional thermal stability, while the 5'-hydroxyl is protected with a dimethoxytrityl (DMTr) group and the 3'-position is functionalized with a cyanoethyl (CE) phosphoramidite for stepwise incorporation. It inherits the high efficiency of LNA modifications while offering improved hydrophilicity and lower toxicity. This phosphoramidite is widely employed in the synthesis of modified oligonucleotides, including antisense strands, siRNAs, and molecular probes, to improve nuclease resistance, enhance hybridization strength, and increase overall therapeutic and diagnostic potential.

CAT: BRP-02700

CAS: 2404654-12-0

Molecular Formula: C42H48N5O9P

Molecular Weight: 797.83

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InChIKey: UTQCMGOOTHXIHS-BHXGXGLPSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@]4(O5)[C@H]([C@H]([C@@H]5N6C=C(C)C(NC6=O)=O)O[C@H]4C#N)OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C42H48N5O9P/c1-27(2)47(28(3)4)57(53-23-11-22-43)56-37-36-39(46-25-29(5)38(48)45-40(46)49)55-41(37,35(24-44)54-36)26-52-42(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-21,25,27-28,35-37,39H,11,23,26H2,1-7H3,(H,45,48,49)/t35-,36+,37-,39+,41-,57?/m0/s1

Synonyms: CN-LNA-T-CE Phosphoramidite; 5'-ODMT CN-LNA m5U Phosphoramidite (Amidite); CN-LNA-m5U phosphoramidite; CN-LNA-m5U-3'-CE-Phosphoramidite; CN-LNA-T phosphoramidite; CN-LNA-5-Me-U Phosphoramidite; CN-LNA-T-CE-Phosphoramidite; (1S,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-cyano-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-O-DMT-2'-O-POM-U-3'-CE-Phosphoramidite

Description: 5'-O-DMT-2'-O-POM-U-3'-CE Phosphoramidite is a chemically modified uridine building block used in solid-phase oligonucleotide synthesis, where the ribose carries a 2'-O-(pivaloyloxymethyl) (POM) protecting group that enhances stability and modulates oligonucleotide properties. The uracil nucleobase remains unprotected, the 5'-hydroxyl is protected with a dimethoxytrityl (DMT) group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for stepwise incorporation into oligonucleotide chains. This reagent is typically employed in the preparation of modified RNAs and therapeutic oligonucleotides, where the POM modification can influence nuclease resistance, pharmacokinetics, and biological performance while retaining efficient hybridization with complementary sequences.

CAT: BRP-02701

Molecular Formula: C45H57N4O11P

Molecular Weight: 860.94

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InChIKey: CWFIVBQKXNPXJJ-WXSPLRIASA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCOC(=O)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: [(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxymethyl 2,2-dimethylpropanoate

InChI: InChI=1S/C45H57N4O11P/c1-30(2)49(31(3)4)61(58-27-13-25-46)60-39-37(59-41(48-26-24-38(50)47-43(48)52)40(39)55-29-56-42(51)44(5,6)7)28-57-45(32-14-11-10-12-15-32,33-16-20-35(53-8)21-17-33)34-18-22-36(54-9)23-19-34/h10-12,14-24,26,30-31,37,39-41H,13,27-29H2,1-9H3,(H,47,50,52)/t37-,39-,40-,41-,61?/m1/s1

Synonyms: (((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate; 5'-O-DMT-2'-O-(pivaloyloxymethyl)uridine 3'-CE phosphoramidite; 2'-O-POM-U-3'-phosphoramidite; 5'-O-DMTr-2'-O-(2-pivaloyloxymethyl)-uridine-3'-CED-phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-pivaloyloxymethyl)uridine 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-(2-pivaloyloxymethyl)uridine

5'-O-DMT-2'-O-POM-A(Bz)-3'-CE-Phosphoramidite

Description: 5'-O-DMT-2'-O-POM-A(Bz)-3'-CE Phosphoramidite is an adenosine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, incorporating a 2'-O-(pivaloyloxymethyl) (POM) modification on the ribose to enhance stability and optimize pharmacological properties. The adenine base is protected with a benzoyl (Bz) group, the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite, enabling stepwise chain elongation. This reagent is widely used in the synthesis of modified RNAs and therapeutic oligonucleotides, where the POM modification contributes to improved nuclease resistance, altered pharmacokinetics, and reliable hybridization performance with complementary sequences.

CAT: BRP-02702

Molecular Formula: C53H62N7O10P

Molecular Weight: 988.09

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InChIKey: MVMDULHZEUVEIS-AEBGNYAMSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H](OCOC(C(C)(C)C)=O)[C@H](N2C=NC3=C(NC(C4=CC=CC=C4)=O)N=CN=C23)O[C@@H]1COC(C5=CC=C(OC)C=C5)(C6=CC=C(OC)C=C6)C7=CC=CC=C7

IUPAC Name: (((2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl)oxy)methyl pivalate

InChI: InChI=1S/C53H62N7O10P/c1-35(2)60(36(3)4)71(68-30-16-29-54)70-45-43(31-67-53(38-19-14-11-15-20-38,39-21-25-41(63-8)26-22-39)40-23-27-42(64-9)28-24-40)69-50(46(45)65-34-66-51(62)52(5,6)7)59-33-57-44-47(55-32-56-48(44)59)58-49(61)37-17-12-10-13-18-37/h10-15,17-28,32-33,35-36,43,45-46,50H,16,30-31,34H2,1-9H3,(H,55,56,58,61)/t43-,45-,46-,50-,71?/m1/s1

Synonyms: N6-Benzoyl-5'-O-DMT-2'-O-((pivaloyloxymethyl))adenosine 3'-CE phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-((pivaloyloxymethyl))adenosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphorramidite; N6-Bz-5'-O-DMTr-2'-O-((pivaloyloxymethyl))-adenosine-3'-CED-phosphoramidite; 2'-O-POM-A(Bz)-3'-phosphoramidite; N6-Benzoyl-5'-O-DMT-2'-O-POM-adenosine 3'-CE phosphoramidite; DMT-2'-O-POM-A(Bz)-CE-Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(pivaloyloxymethyl)-adenosine-3'-cyanoethyl Phosphoramidite

5'-O-DMT-2'-O-POM-C(Ac)-3'-CE-Phosphoramidite

Description: 5'-O-DMT-2'-O-POM-C(Ac)-3'-CE Phosphoramidite is a cytidine-derived phosphoramidite building block designed for solid-phase oligonucleotide synthesis, featuring a 2'-O-(pivaloyloxymethyl) (POM) modification on the ribose that enhances chemical stability and modulates oligonucleotide properties. The cytosine base is protected with an acetyl (Ac) group to prevent undesired side reactions, while the 5'-hydroxyl is safeguarded by a dimethoxytrityl (DMT) group and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for efficient stepwise incorporation. This reagent is employed in the synthesis of modified RNAs and therapeutic oligonucleotides, where the POM modification provides improved nuclease resistance, influences pharmacokinetic behavior, and helps maintain effective hybridization with complementary strands.

CAT: BRP-02703

Molecular Formula: C47H60N5O11P

Molecular Weight: 901.99

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InChIKey: XGSYTNZPEKBGAM-JFALYFJISA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCOC(=O)C(C)(C)C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: [(2R,3R,4R,5R)-2-(4-acetamido-2-oxopyrimidin-1-yl)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-3-yl]oxymethyl 2,2-dimethylpropanoate

InChI: InChI=1S/C47H60N5O11P/c1-31(2)52(32(3)4)64(61-28-14-26-48)63-41-39(62-43(42(41)58-30-59-44(54)46(6,7)8)51-27-25-40(49-33(5)53)50-45(51)55)29-60-47(34-15-12-11-13-16-34,35-17-21-37(56-9)22-18-35)36-19-23-38(57-10)24-20-36/h11-13,15-25,27,31-32,39,41-43H,14,28-30H2,1-10H3,(H,49,50,53,55)/t39-,41-,42-,43-,64?/m1/s1

Synonyms: (((2R,3R,4R,5R)-2-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl)oxy)methyl pivalate; N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-(pivaloyloxymethyl)cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-(pivaloyloxymethyl)-N4-Acetyl-cytidine 3'-CE phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-O-(pivaloyloxymethyl)cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMTr-N4-Ac-2'-O-POM-cytidine-3'-CED Phosphoramidite; DMT-2'-O-POM-rC(Ac) Phosphoramidite; 2'-O-POM-Ac-rC-CE-Phosphoramidite; 5'-DMT-2'-O-POM-N4-Acetyl-Cytidine Phosphoramidite

5'-O-DMT-2'-O-POM-G(iBu)-3'-CE-Phosphoramidite

Description: 5'-O-DMT-2'-O-POM-G(iBu)-3'-CE Phosphoramidite is a guanosine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, featuring a 2'-O-(pivaloyloxymethyl) (POM) modification on the ribose that enhances stability and modulates pharmacological behavior. The guanine base is protected with an isobutyryl (iBu) group, the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) protecting group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for stepwise incorporation during automated synthesis. This reagent is employed in the preparation of modified RNAs and therapeutic oligonucleotides, where the POM substitution provides improved nuclease resistance, influences pharmacokinetic properties, and supports strong and selective hybridization with complementary strands.

CAT: BRP-02704

Molecular Formula: C50H64N7O11P

Molecular Weight: 970.07

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InChIKey: HLRNGXGLQFPUJA-NWGULGMGSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H](OCOC(C(C)(C)C)=O)[C@H](N2C=NC3=C2N=C(NC(C(C)C)=O)NC3=O)O[C@@H]1COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

IUPAC Name: (((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate

InChI: InChI=1S/C50H64N7O11P/c1-31(2)44(58)54-48-53-43-40(45(59)55-48)52-29-56(43)46-42(63-30-64-47(60)49(7,8)9)41(68-69(66-27-15-26-51)57(32(3)4)33(5)6)39(67-46)28-65-50(34-16-13-12-14-17-34,35-18-22-37(61-10)23-19-35)36-20-24-38(62-11)25-21-36/h12-14,16-25,29,31-33,39,41-42,46H,15,27-28,30H2,1-11H3,(H2,53,54,55,58,59)/t39-,41-,42-,46-,69?/m1/s1

Synonyms: 2'-OPOM-iBu-G-CE Phosphoramidite; DMT-2'-O-POM-G(iBu)-CE Phosphoramidite; 2'-O-POM Guanosine (iBu) CED phosphoramidite; 2'-O-POM-G(iBu)-3'-phosphoramidite; 5'-O-DMTr-N2-iBu-2'-O-POM-guanosine-3'-CED phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyroyl-2'-O-(pivaloyloxymethyl)guanosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N2-isobutyryl-2'-O-(pivaloyloxymethyl)guanosine 3'-CE phosphoramidite; 5'-O-DMT-2'-O-POM-G(iBu) phosporamidite; DMT-2'-O-POM-rG(iBu) amidite; N2-Isobutyryl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(pivaloyloxymethyl)-Guanosine-3'-CE-Phosphoramidite

N4-Benzoyl-5'-O-DMT-2'-O-propargyl-5-methylcytidine 3'-CE phosphoramidite

Description: N4-Benzoyl-5'-O-DMT-2'-O-propargyl-5-methylcytidine 3'-CE phosphoramidite is a cytidine-derived phosphoramidite building block designed for solid-phase oligonucleotide synthesis, where the ribose carries a 2'-O-propargyl substituent that introduces an alkyne functionality for post-synthetic conjugation via click chemistry. The cytosine base is 5-methyl-substituted for enhanced duplex stability and protected at the exocyclic amino group with a benzoyl (Bz) group, while the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) group and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for efficient stepwise incorporation. This reagent is used in the synthesis of chemically modified oligonucleotides, enabling site-specific labeling, bioconjugation, and structural tuning, while providing enhanced stability, hybridization strength, and versatile functionalization potential for therapeutic and diagnostic applications.

CAT: BRP-02705

Molecular Formula: C50H56N5O9P

Molecular Weight: 901.98

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InChIKey: OJIBJDRBHLCQGW-BRQQSDFOSA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C(C)=C5)=O)[C@H](OCC#C)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H56N5O9P/c1-9-30-60-45-44(64-65(62-31-16-29-51)55(34(2)3)35(4)5)43(63-48(45)54-32-36(6)46(53-49(54)57)52-47(56)37-17-12-10-13-18-37)33-61-50(38-19-14-11-15-20-38,39-21-25-41(58-7)26-22-39)40-23-27-42(59-8)28-24-40/h1,10-15,17-28,32,34-35,43-45,48H,16,30-31,33H2,2-8H3,(H,52,53,56,57)/t43-,44-,45-,48-,65?/m1/s1

Synonyms: 2'-O-propargyl 5-Methylcytidine (n-bz) CED phosphoramidite; 2'-O-Propargyl 5-Me-C(Bz)-3'-phosphoramidite; DMTr-5-Methyl-2'-O-propargyl-rC(Bz)-3'-CE-Phosphoramidite; N4-Bz-5-Methyl-DMT-2'-O-propargyl-C-CE-Phosphoramidite; N4-Benzoyl-5-methyl-5'-O-DMT-2'-O-propargylcytidine 3'-CE phosphoramidite; 2'-O-PA-N4-Bz-5-Me-C Phosphoramidite; 5-Me-DMT-2'-O-PA-C(Bz)-CEP; N4-Benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-cytidine-3'-cyanoethyl phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-propargyl-5-methyl-3,4-dihydrocytidine; 5'-O-DMT-2'-O-PA-MeC(Bz) 3'-CE phosphoramidite; 5'-O-DMT-N4-Benzoyl-5-Methy-2'-O-propargylcytidine 3'-CE phosphoramidite; 2'-O-Allynyl MeC(Bz)-3'-phosphoramidite

2'-O-Propargyl-G(dmf)-CE-Phosphoramidite

Description: 2'-O-Propargyl-G(dmf)-CE-Phosphoramidite is a guanosine-derived phosphoramidite building block for solid-phase oligonucleotide synthesis, in which the ribose is modified at the 2'-position with a propargyl group that introduces an alkyne handle for post-synthetic functionalization through click chemistry. The guanine base is protected with a dimethylformamide (dmf) group to block the exocyclic amino position, the 5'-hydroxyl is typically protected with a dimethoxytrityl (DMT) group, and the 3'-hydroxyl is functionalized as a cyanoethyl (CE) phosphoramidite for controlled chain elongation. This reagent is widely applied in the preparation of modified RNA and DNA oligonucleotides, where the propargyl moiety enables site-specific conjugation with fluorophores, affinity tags, or other chemical functionalities, while maintaining good hybridization properties and stability for both therapeutic and diagnostic uses.

CAT: BRP-02706

CAS: 210096-46-1

Molecular Formula: C46H55N8O8P

Molecular Weight: 878.95

Purity: ≥98%

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InChIKey: BKQBXSOYIXLAFJ-SLLDXECHSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCC#C)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C46H55N8O8P/c1-10-26-58-41-40(62-63(60-27-14-25-47)54(31(2)3)32(4)5)38(61-44(41)53-30-48-39-42(53)50-45(51-43(39)55)49-29-52(6)7)28-59-46(33-15-12-11-13-16-33,34-17-21-36(56-8)22-18-34)35-19-23-37(57-9)24-20-35/h1,11-13,15-24,29-32,38,40-41,44H,14,26-28H2,2-9H3,(H,50,51,55)/t38-,40-,41-,44-,63?/m1/s1

Synonyms: N2-DMF-5'-O-DMTr-2'-O-propargylguanosine-3'-CED-phosphoramidite; N2-Dimethylformamide-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-guanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N2-dimethylformamide-2'-O-propynylguanosine 3'-CE phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-N-dimethylformamide-2'-O-2-propyn-1-ylguanosine; DMTr-2'-O-propargyl-rG(dmf)-3'-CE-Phosphoramidite; 5'-O-DMT-2'-O-Propargyl-N2-dimethylformamide-Guanosine 3'-CE phosphoramidite; N2-DMF-5'-O-DMT-2'-O-propargyl-G-CE-Phosphoramidite; 2'-O-propargyl Guanosine (n-dmf) CED phosphoramidite; 2'-O-Propargyl G(DMF)-3'-phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-2-propynyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]