What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

5'-O-DMT-3'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine 2'-CE phosphoramidite (BRP-02175)

Description: 5'-O-DMT-3'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine 2'-CE phosphoramidite is a specialized phosphoramidite used for the synthesis of oligonucleotides. It includes a 5'-dimethoxytrityl (DMT) group for 5'-hydroxyl protection, a 3'-tert-butyldimethylsilyl (TBDMS) group for 3'-hydroxyl protection, and an N2-isobutyryl group to protect the exocyclic amine of the guanine base. Additionally, it has a cyanoethyl (CE) group at the 2'-position of the phosphoramidite. These protective groups help facilitate efficient synthesis and stability of the oligonucleotides, making this compound valuable for research, diagnostic, and therapeutic applications.

CAT: BRP-02175

CAS: 1445905-51-0

Molecular Formula: C50H68N7O9PSi

Molecular Weight: 970.18

Purity: ≥95%

Appearance: White, off-white to faint yellow powder

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InChIKey: JCCWPNDXSMAHGZ-FTZVBZPOSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O[Si](C)(C)C(C)(C)C)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C50H68N7O9PSi/c1-32(2)45(58)54-48-53-44-41(46(59)55-48)52-31-56(44)47-43(65-67(63-29-17-28-51)57(33(3)4)34(5)6)42(66-68(12,13)49(7,8)9)40(64-47)30-62-50(35-18-15-14-16-19-35,36-20-24-38(60-10)25-21-36)37-22-26-39(61-11)27-23-37/h14-16,18-27,31-34,40,42-43,47H,17,29-30H2,1-13H3,(H2,53,54,55,58,59)/t40-,42-,43-,47-,67?/m1/s1

Synonyms: 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine 2'-CE phosphoramidite; (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 3'-TBDMS-ibu-rG Phosphoramidite; 3'-O-TBDMS-5'-O-DMT-N2-iBu-rG CED phosphoramidite; 5'-O-DMTr-2'-O-TBDMS-L-G(iBu)-3'-CE-Phosphoramidite; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-L-guanosine-3'-cyanoethyl Phosphoramidite

N4-Bz-5'-O-DMTr-2'-O-Me-cytidine-3'-CED-phosphoramidite (BRP-02177)

Description: N4-Bz-5'-O-DMTr-2'-O-Me-cytidine-3'-CED-phosphoramidite is a modified phosphoramidite designed for use in the synthesis of stable and efficient oligonucleotides. Its protective groups and modifications enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in the production of antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

CAT: BRP-02177

CAS: 110764-78-8

Molecular Formula: C47H54N5O9P

Molecular Weight: 863.93

Purity: ≥95%

Appearance: White Powder

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InChIKey: JFFSFQRVIPPCBC-VKBHKTMGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C47H54N5O9P/c1-32(2)52(33(3)4)62(59-30-14-28-48)61-42-40(60-45(43(42)57-7)51-29-27-41(50-46(51)54)49-44(53)34-15-10-8-11-16-34)31-58-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3,(H,49,50,53,54)/t40-,42-,43-,45-,62?/m1/s1

Synonyms: N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methycytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 2'-O-Me-C(Bz)-3'-phosphoramidite; 2'-OMe-Bz-C Phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methylcytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-methylcytidine; N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-methyl-adenosine 3'-CE phosphoramidite (BRP-02185)

Description: 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-methyl-adenosine 3'-CE phosphoramidite is a vital compound used in the biomedical industry for synthesizing RNA molecules. This phosphoramidite aids in the incorporation of modified adenosine bases during RNA synthesis, enabling researchers to study specific drug targets or diseases related to N6-methyladenosine methylation. By providing precise adenosine modifications, this product facilitates the investigation of gene expression and regulatory mechanisms, leading to potential breakthroughs in drug discovery and disease understanding.

CAT: BRP-02185

CAS: 588698-79-7

Molecular Formula: C47H64N7O7PSi

Molecular Weight: 898.11

Purity: ≥98% by HPLC

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Boiling Point: 859.0±75.0°C (Predicted)

InChIKey: GPLFLRPEMRRWIR-UTZPQXNGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-[6-(methylamino)purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C47H64N7O7PSi/c1-32(2)54(33(3)4)62(58-28-16-27-48)60-41-39(59-45(42(41)61-63(11,12)46(5,6)7)53-31-52-40-43(49-8)50-30-51-44(40)53)29-57-47(34-17-14-13-15-18-34,35-19-23-37(55-9)24-20-35)36-21-25-38(56-10)26-22-36/h13-15,17-26,30-33,39,41-42,45H,16,28-29H2,1-12H3,(H,49,50,51)/t39-,41-,42-,45-,62?/m1/s1

Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Me-rA phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-N-methyladenosine; N6-Me-DMT-2'-O-TBDMS-A-CE Phosphoramidite; N6-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-adenosine-3'-cyanoethyl-Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-N6-methyl-Adenosine 3'-CE phosphoramidite; DMTr-2'-O-TBDMS-N6-Me-rA-3'-CE-Phosphoramidite

N2-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-guanosine 3'-CE phosphoramidite (BRP-02187)

Description: Commonly used protected 2-OTBDMS phosphoramidite for incorporation of nucleotide-G into the synthesis of oligonucleotides.

CAT: BRP-02187

CAS: 944138-03-8

Molecular Formula: C48H64N7O9PSi

Molecular Weight: 942.12

Purity: ≥98%

Appearance: White, off-white to yellow powder

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InChIKey: DGDYJRDKFZTURB-WUYIOLTESA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C2N=C(NC3=O)NC(=O)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]acetamide

InChI: InChI=1S/C48H64N7O9PSi/c1-31(2)55(32(3)4)65(61-28-16-27-49)63-41-39(29-60-48(34-17-14-13-15-18-34,35-19-23-37(58-9)24-20-35)36-21-25-38(59-10)26-22-36)62-45(42(41)64-66(11,12)47(6,7)8)54-30-50-40-43(54)52-46(51-33(5)56)53-44(40)57/h13-15,17-26,30-32,39,41-42,45H,16,28-29H2,1-12H3,(H2,51,52,53,56,57)/t39-,41-,42-,45-,65-/m1/s1

Synonyms: Ac-G-CE Phosphoramidite; 5'-O-DMTr-2'-O-TBDMS-G(Ac)-3'-CE-Phosphoramidite; N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanine-3'-cyanoethyl Phosphoramidite; 2'-O-[(tert-Butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-DMT-2'-TBDMS-rG(N-Ac) Phosphoramidite; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-TBDMS-G CEP; DMT-2'-O-TBDMS-G(Ac) 3'-CE-Phosphoramidite

5'-O-DMT-2'-O-TBDMS-N2-ibu-2-aminoadenosine 3'-CE phosphoramidite (BRP-02188)

Description: 5'-O-DMT-2'-O-TBDMS-N2-ibu-2-aminoadenosine 3'-CE phosphoramidite is a compound assuming a pivotal role in oligonucleotide modification. Employed extensively in diverse applications such as targeted drug delivery systems, this phosphoramidite plays a pioneering role in the quest for refined therapeutics that combat distinctive ailments like cancer and genetic anomalies.

CAT: BRP-02188

Molecular Formula: C50H69N8O8PSi

Molecular Weight: 969.21

Purity: ≥97% by HPLC

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InChIKey: NKCWJSASWRVTLE-FTZVBZPOSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-amino-2-isobutyramido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H69N8O8PSi/c1-32(2)46(59)56-48-54-44(52)41-45(55-48)57(31-53-41)47-43(66-68(12,13)49(7,8)9)42(65-67(63-29-17-28-51)58(33(3)4)34(5)6)40(64-47)30-62-50(35-18-15-14-16-19-35,36-20-24-38(60-10)25-21-36)37-22-26-39(61-11)27-23-37/h14-16,18-27,31-34,40,42-43,47H,17,29-30H2,1-13H3,(H3,52,54,55,56,59)/t40-,42-,43-,47-,67?/m1/s1

Synonyms: DMT-2'-O-TBDMS-N2-iBu-2-aminoadenosine phosphoramidite; DMT-2'-O-TBDMS-N2-iBu-A-CE-Phosphoramidite; 5'-O-DMTr-2'-O-TBDMS-N2-iBu-A-3'-CE-Phosphoramidite; 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N2-isobutyryladenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine 3'-CE phosphoramidite (BRP-02189)

Description: 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine 3'-CE phosphoramidite, a critical and indispensable reagent in the highly esteemed biomedical industry, manifests its profound significance in the realm of modified nucleic acids synthesis. Its exceptional utility primarily lies in its adeptness for effectuating the introduction of the esteemed 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine moiety during phosphoramidite-mediated DNA synthesis. This unparalleled product unveils a wealth of opportunities within the sphere of nucleic acid-based therapeutic development, acting as a fulcrum for groundbreaking research directed towards unravelling the complexities of diverse disease entities and optimizing drug targeting strategies.

CAT: BRP-02189

Molecular Formula: C53H65IN7O8PSi

Molecular Weight: 1114.11

Purity: ≥97% by HPLC

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InChIKey: YIYILOGGUDEHPF-UFCBNZGASA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-8-iodo-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H65IN7O8PSi/c1-35(2)61(36(3)4)70(66-32-18-31-55)68-45-43(33-65-53(38-21-16-13-17-22-38,39-23-27-41(63-8)28-24-39)40-25-29-42(64-9)30-26-40)67-50(46(45)69-71(10,11)52(5,6)7)60-48-44(58-51(60)54)47(56-34-57-48)59-49(62)37-19-14-12-15-20-37/h12-17,19-30,34-36,43,45-46,50H,18,32-33H2,1-11H3,(H,56,57,59,62)/t43-,45-,46-,50-,70?/m1/s1

Synonyms: 8-I-rA phosphoramidite; DMT-2'-O-TBDMS-8-I-A(Bz)-CE-Phosphoramidite; N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-8-Iodoadenosine 3'-CE phosphoramidite; 5'-O-DMT-2'-O-TBDMS-8-I-A(Bz)-3'-CE-Phosphoramidite

5'-O-DMT-N4-Acetyl-2'-fluoro-2'-arabinofuranosyl-deoxycytidine 3'-CE phosphoramidite (BRP-02190)

Description: 5'-O-DMT-N4-Acetyl-2'-fluoro-2'-arabinofuranosyl-deoxycytidine 3'-CE phosphoramidite is a crucial reagent extensively used in the biomedical industry for the synthesis of nucleosides and nucleotides. This product plays a significant role in the development of therapeutic drugs targeting various diseases, including viral infections and cancer. With its unique properties, it enables researchers to design and fabricate novel nucleoside analogs with potential antiviral and anticancer activities, contributing to advancements in biomedicine.

CAT: BRP-02190

Molecular Formula: C41H49FN5O8P

Molecular Weight: 789.83

Purity: ≥97% by HPLC

Appearance: Off-white solid

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InChIKey: CNFKJHKDSRXNFL-AXLBFYELSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C41H49FN5O8P/c1-27(2)47(28(3)4)56(53-25-11-23-43)55-38-35(54-39(37(38)42)46-24-22-36(44-29(5)48)45-40(46)49)26-52-41(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,44,45,48,49)/t35-,37+,38-,39-,56?/m1/s1

Synonyms: 2'-F-2'-ara-Ac-dC Phosphoramidite; 4-Acetamido-1-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl}-2(1H)-pyrimidinone; 2(1H)-Pyrimidinone, 4-(acetylamino)-1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-; N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-deoxy-2'-fluorocytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 2'-F-ANA-rC(N-Ac) Phosphoramidite

N4-Benzoyl-5'-O-DMT-2'-O-MOE-cytidine 3'-CE phosphoramidite (BRP-02191)

Description: N4-Benzoyl-5'-O-DMT-2'-O-MOE-cytidine 3'-CE phosphoramidite is a modified phosphoramidite designed for efficient and controlled synthesis of RNA and DNA oligonucleotides. The protective groups and modifications, such as N4-benzoyl, 5'-O-DMTr, and 2'-O-MOE, enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in the production of antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

CAT: BRP-02191

CAS: 251647-54-8

Molecular Formula: C49H58N5O10P

Molecular Weight: 907.99

Purity: ≥95%

Appearance: White Powder

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InChIKey: IAFVTVZPQIFRAU-NXPFYNPLSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-methoxyethoxy)oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C49H58N5O10P/c1-34(2)54(35(3)4)65(62-30-14-28-50)64-44-42(63-47(45(44)60-32-31-57-5)53-29-27-43(52-48(53)56)51-46(55)36-15-10-8-11-16-36)33-61-49(37-17-12-9-13-18-37,38-19-23-40(58-6)24-20-38)39-21-25-41(59-7)26-22-39/h8-13,15-27,29,34-35,42,44-45,47H,14,30-33H2,1-7H3,(H,51,52,55,56)/t42-,44-,45-,47-,65?/m1/s1

Synonyms: N4-Bz-5'-O-DMTr-2'-O-(2-methoxyethyl)cytidine-3'-CED-phosphoramidite; 2'-O-MOE-C(Bz)-3'-phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-CE-cyanoethyl Phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-(2-methoxyethyl)cytidine; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-O-MOE-rC(Bz) Phosphoramidite

5'-O-DMT-N4-Benzoyl-3'-O-tert-butyldimethylsilyl-cytidine 2'-CE phosphoramidite (BRP-02193)

Description: 5'-O-DMT-N4-Benzoyl-3'-O-tert-butyldimethylsilyl-cytidine 2'-CE phosphoramidite, a highly acclaimed reagent in the realm of biomedicine, exhibits unparalleled significance. Notably, this phosphoramidite derivative finds widespread employment in the synthesis of altered oligonucleotides, exuding immense promise for gene therapy, drug conveyance, and diagnostic modalities.

CAT: BRP-02193

CAS: 129470-47-9

Molecular Formula: C52H66N5O9PSi

Molecular Weight: 964.17

Purity: ≥97% by HPLC

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InChIKey: KGHSXHZESVOJIE-YOVDOAOFSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C52H66N5O9PSi/c1-36(2)57(37(3)4)67(63-34-18-32-53)65-47-46(66-68(10,11)51(5,6)7)44(64-49(47)56-33-31-45(55-50(56)59)54-48(58)38-19-14-12-15-20-38)35-62-52(39-21-16-13-17-22-39,40-23-27-42(60-8)28-24-40)41-25-29-43(61-9)30-26-41/h12-17,19-31,33,36-37,44,46-47,49H,18,34-35H2,1-11H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m1/s1

Synonyms: N4-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine 2'-CE phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 3'-TBDMS-Bz-rC Phosphoramidite; 3'-O-TBDMS-5'-O-DMT-N4-Bz-rC CED phosphoramidite; 5'-O-DMT-3'-TBDMS-N4-benzoyl-cytidine 2'-CE phosphoramidite

Ac-dG Phosphoramidite (BRP-02196)

Description: Ac-dG Phosphoramidite is a modified phosphoramidite designed for efficient and controlled synthesis of DNA oligonucleotides. The 5'-O-DMTr and N2-acetyl protective groups ensure stability and facilitate precise addition during solid-phase synthesis, making it valuable for producing high-quality DNA probes, primers, and therapeutic oligonucleotides.

CAT: BRP-02196

CAS: 2417251-95-5

Molecular Formula: C42H50N7O8P

Molecular Weight: 811.88

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InChIKey: XMEBTRUEVNJJBZ-WFPBXDAHSA-N

CanonicalSMILES: N#CCCOP(OC1CC(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=NC=6C(=O)N=C(NC(=O)C)NC65)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H50N7O8P/c1-27(2)49(28(3)4)58(55-23-11-22-43)57-35-24-37(48-26-44-38-39(48)46-41(45-29(5)50)47-40(38)51)56-36(35)25-54-42(30-12-9-8-10-13-30,31-14-18-33(52-6)19-15-31)32-16-20-34(53-7)21-17-32/h8-10,12-21,26-28,35-37H,11,23-25H2,1-7H3,(H2,45,46,47,50,51)/t35-,36+,37+,58?/m0/s1

Synonyms: Ac-dG-CE Phosphoramidite; 5'-Dimethoxytrityl-N2-acetyl-2'-deoxyguanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5'-O-DMTr-N2-Ac-2'-deoxy-guanosine-3'-CED phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-acetyl-2'-deoxy-guanosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 2'-deoxy-G(Ac) CE phosphoramidite; 5'-O-DMT-2'-deoxy-G(Ac) phosporamidite; DMT-2'-deoxy-rG(Ac) amidite

Bn-dU CEP (BRP-02197)

Description: Bn-dU CEP is a modified phosphoramidite used in oligonucleotide synthesis. It features a benzylcarbamoyl group attached to the 5-position of the 2'-deoxyuridine (dU) base, and is equipped with a cyanoethyl (CE) protecting group on the phosphoramidite moiety. This modification allows for the incorporation of the benzylcarbamoyl group into synthetic DNA sequences, potentially altering the properties of the resulting oligonucleotides for specific biochemical and biophysical applications.

CAT: BRP-02197

Molecular Formula: C47H54N5O9P

Molecular Weight: 863.95

Purity: ≥95%

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InChIKey: IBKSJCLOSMZOIH-PJQDADNVSA-N

IUPAC Name: (2R,3S,5R)-5-(5-(benzylcarbamoyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H54N5O9P/c1-32(2)52(33(3)4)62(59-27-13-26-48)61-41-28-43(51-30-40(45(54)50-46(51)55)44(53)49-29-34-14-9-7-10-15-34)60-42(41)31-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30,32-33,41-43H,13,27-29,31H2,1-6H3,(H,49,53)(H,50,54,55)/t41-,42+,43+,62?/m0/s1

Synonyms: Bn-Du Phosphoramidite; 5-(Benzylcarbamoyl)-dU CE-Phosphoramidite; 5-(Benzylcarbamoyl)-2'-deoxy-dU CE-Phosphoramidite; Bn-dU 3'-CE-Phosphoramidite

C8-Alkyne-dA CEP (BRP-02198)

Description: C8-Alkyne-dA phosphoramidite is a specialized phosphoramidite used in the chemical synthesis of oligonucleotides. It features an alkyne group attached to the C8 position of deoxyadenosine, allowing for click chemistry reactions, such as the attachment of various functional groups or labels. This phosphoramidite is used to introduce reactive alkyne moieties into oligonucleotides, facilitating the creation of modified nucleic acids for applications in molecular biology, diagnostics, and the development of therapeutic agents.

CAT: BRP-02198

CAS: 1002322-75-9

Molecular Formula: C53H63N6O7P

Molecular Weight: 927.10

Purity: ≥95%

Appearance: White to Off-white Foam

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Boiling Point: 955.7±65.0°C at 760 mmHg

InChIKey: DMVMVASVMSMXMZ-MVAJTOPMSA-N

CanonicalSMILES: N#CCCOP(OC1CC(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=C(C#CCCCCC#C)C=6C(=NC=NC65)NC(=O)C(C)C)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-isobutyramido-5-(octa-1,7-diyn-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H63N6O7P/c1-10-11-12-13-14-16-20-40-34-58(51-49(40)50(55-36-56-51)57-52(60)37(2)3)48-33-46(66-67(64-32-19-31-54)59(38(4)5)39(6)7)47(65-48)35-63-53(41-21-17-15-18-22-41,42-23-27-44(61-8)28-24-42)43-25-29-45(62-9)30-26-43/h1,15,17-18,21-30,34,36-39,46-48H,11-14,19,32-33,35H2,2-9H3,(H,55,56,57,60)/t46-,47+,48+,67?/m0/s1

Synonyms: C8-Alkyne-dA Phosphoramidite; Propanamide, N-[7-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-5-(1,7-octadiyn-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-methyl-; N-[7-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-5-(1,7-octadiyn-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-methylpropanamide; 7-Deaza-C8-Alkyne-2'-deoxy-adenosine 3'-CE-Phosphoramidite

C-TOM-CE Phosphoramidite (BRP-02199)

Description: The synthesis of RNA using monomers containing the 2'-O-Triisopropylsilyloxymethyl (TOM) group (TOM-Protecting-Group) has very high coupling efficiency along with fast, simple deprotection.

CAT: BRP-02199

CAS: 253586-12-8

Molecular Formula: C51H72N5O10PSi

Molecular Weight: 974.22

Purity: ≥95%

Appearance: White to Off-white Free-flowing Powder

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InChIKey: LAUSLJOCUCNMJI-RLKIZYSKSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCO[Si](C(C)C)(C(C)C)C(C)C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[tri(propan-2-yl)silyloxymethoxy]oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C51H72N5O10PSi/c1-34(2)56(35(3)4)67(63-31-17-29-52)66-47-45(32-62-51(40-18-15-14-16-19-40,41-20-24-43(59-12)25-21-41)42-22-26-44(60-13)27-23-42)65-49(55-30-28-46(53-39(11)57)54-50(55)58)48(47)61-33-64-68(36(5)6,37(7)8)38(9)10/h14-16,18-28,30,34-38,45,47-49H,17,31-33H2,1-13H3,(H,53,54,57,58)/t45-,47-,48-,49-,67?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N-acetyl-Cytidine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N-Acetyl-2'-O-[(triisopropylsilyloxy)methyl]-3'-O-[diisopropylamino(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)cytidine; (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Related CAS: 1509908-11-5 (Deleted CAS)

2,6-Diamino(N2,N6-diPac)-DMT-2'-O-TBDMS-purine riboside-CE-Phosphoramidite (BRP-02200)

Description: 2,6-Diamino(N2,N6-diPac)-DMT-2'-O-TBDMS-purine riboside-CE-phosphoramidite is a modified phosphoramidite reagent used for the synthesis of oligonucleotides. It features multiple protective groups: a dimethoxytrityl (DMT) group at the 5'-hydroxyl position, a tert-butyldimethylsilyl (TBDMS) group at the 2'-hydroxyl position, and cyanoethyl (CE) group on the phosphoramidite at the 3' position. These modifications ensure the stability and integrity of the purine riboside during the synthesis process, facilitating the creation of high-quality, stable oligonucleotides for research and therapeutic applications.

CAT: BRP-02200

CAS: 2101776-87-6

Molecular Formula: C62H75N8O11PSi

Molecular Weight: 1167.37

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InChIKey: LFCZZILBKNBHDI-IGXISVFNSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=C(N=C32)NC(=O)COC4=CC=CC=C4)NC(=O)COC5=CC=CC=C5)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC

InChI: InChI=1S/C62H75N8O11PSi/c1-42(2)70(43(3)4)82(78-37-21-36-63)80-55-51(38-77-62(44-22-15-12-16-23-44,45-28-32-47(73-8)33-29-45)46-30-34-48(74-9)35-31-46)79-59(56(55)81-83(10,11)61(5,6)7)69-41-64-54-57(65-52(71)39-75-49-24-17-13-18-25-49)67-60(68-58(54)69)66-53(72)40-76-50-26-19-14-20-27-50/h12-20,22-35,41-43,51,55-56,59H,21,37-40H2,1-11H3,(H2,65,66,67,68,71,72)/t51-,55-,56-,59-,82?/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(2,6-bis(2-phenoxyacetamido)-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Diaminopurine (di-PAC) CED phosphoramidite; 2,6-Diamino(N2,N6-diPhenoxyacetyl)-5'-O-(4,4'-Dimethoxytrityl)-2'-O-tert-butyldimethylsilyl-purine riboside-3'-cyanoethyl Phosphoramidite; DMT-2'-O-TBDMS-N2-Pac-A(N6-Pac) 3'-CE-Phosphoramidite

G-TOM-CE Phosphoramidite (BRP-02201)

CAT: BRP-02201

CAS: 253586-14-0

Molecular Formula: C52H72N7O10PSi

Molecular Weight: 1014.24

Purity: ≥98% by HPLC

Appearance: White to Golden Free-flowing Powder

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InChIKey: IVLLKXVYBCLHEZ-VPVWFKJASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCO[Si](C(C)C)(C(C)C)C(C)C)N2C=NC3=C2N=C(NC3=O)NC(=O)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[tri(propan-2-yl)silyloxymethoxy]oxolan-2-yl]-6-oxo-1H-purin-2-yl]acetamide

InChI: InChI=1S/C52H72N7O10PSi/c1-33(2)59(34(3)4)70(66-29-17-28-53)69-46-44(30-65-52(39-18-15-14-16-19-39,40-20-24-42(62-12)25-21-40)41-22-26-43(63-13)27-23-41)68-50(47(46)64-32-67-71(35(5)6,36(7)8)37(9)10)58-31-54-45-48(58)56-51(55-38(11)60)57-49(45)61/h14-16,18-27,31,33-37,44,46-47,50H,17,29-30,32H2,1-13H3,(H2,55,56,57,60,61)/t44-,46-,47-,50-,70?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N-acetyl-Guanosine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-guanosine-Phosphoramidite; N-Acetyl-2'-O-[(triisopropylsilyloxy)methyl]-3'-O-[diisopropylamino(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)guanosine; Guanosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-TOM-G(Ac) Phosphoramidite; DMTr-2'-O-TOM-G(Ac) 3'-CE'-Phosphoramidite; G(Ac)-TOM-CE Phosphoramidite

Nap-dU CE-Phosphoramidite (BRP-02202)

Description: Nap-dU CE-Phosphoramidite is crucial for the automated synthesis of oligonucleotides, providing the necessary protection for functional groups to ensure accurate and efficient sequence assembly. The modified base ''dP'' allows for the incorporation of unique features into the oligonucleotides, which can be tailored for specific research, diagnostic, or therapeutic applications.

CAT: BRP-02202

CAS: 2133842-85-8

Molecular Formula: C51H56N5O9P

Molecular Weight: 913.99

Purity: ≥95%

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InChIKey: WAQZWDAZYFQSHE-CNYVYYQHSA-N

CanonicalSMILES: N#CCCOP(OC1CC(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=C(C(=O)NC5=O)C(=O)NCC6=CC=CC=7C=CC=CC76)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-((naphthalen-1-ylmethyl)carbamoyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H56N5O9P/c1-34(2)56(35(3)4)66(63-29-13-28-52)65-45-30-47(55-32-44(49(58)54-50(55)59)48(57)53-31-37-16-12-15-36-14-10-11-19-43(36)37)64-46(45)33-62-51(38-17-8-7-9-18-38,39-20-24-41(60-5)25-21-39)40-22-26-42(61-6)27-23-40/h7-12,14-27,32,34-35,45-47H,13,29-31,33H2,1-6H3,(H,53,57)(H,54,58,59)/t45-,46+,47+,66?/m0/s1

Synonyms: DMTr-5-[N-(naphthalen-2-ylmethyl)formamide]-dU-3'-CE-Phosphoramidite; Nap-dU CEP; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[5-(naphthalen-1-ylmethyl)carbamoyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

U-TOM-CE Phosphoramidite (BRP-02203)

Description: U-TOM-CE phosphoramidite is a phosphoramidite used in oligonucleotide synthesis. It features the TOM (triisopropylsilyloxymethyl) protecting group at the 2'-hydroxyl position and a cyanoethyl (CE) protecting group on the phosphoramidite at the 3' position. The TOM group provides protection during synthesis and can be removed under mild conditions, making this reagent useful for synthesizing RNA oligonucleotides. This phosphoramidite reagent enhances the stability and efficiency of oligonucleotide synthesis, which is crucial for applications in molecular biology, diagnostics, and therapeutic development.

CAT: BRP-02203

CAS: 220230-62-6

Molecular Formula: C49H69N4O10PSi

Molecular Weight: 933.17

Purity: ≥95%

Appearance: White to Off-white Free-flowing Powder

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InChIKey: FKVFIIQPEPLSRC-BIPLCDCWSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCO[Si](C(C)C)(C(C)C)C(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-[tri(propan-2-yl)silyloxymethoxy]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C49H69N4O10PSi/c1-33(2)53(34(3)4)64(60-30-16-28-50)63-45-43(62-47(52-29-27-44(54)51-48(52)55)46(45)58-32-61-65(35(5)6,36(7)8)37(9)10)31-59-49(38-17-14-13-15-18-38,39-19-23-41(56-11)24-20-39)40-21-25-42(57-12)26-22-40/h13-15,17-27,29,33-37,43,45-47H,16,30-32H2,1-12H3,(H,51,54,55)/t43-,45-,46-,47-,64?/m1/s1

Synonyms: 5'-Dimethoxytrityl-Uridine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-[(Triisopropylsilyloxy)methyl]-3'-O-[diisopropylamino(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)uridine; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-O-TOM-U-3'-CE Phosphoramidite

Related CAS: 1509908-14-8 (Deleted CAS)

Spacer C12 CE Phosphoramidite (BRP-02205)

Description: Spacer phosphoramidites C3, 9, and 18 are used to insert spacer arms in oligonucleotides. When a longer spacer is required, the compound can be added multiple times.

CAT: BRP-02205

CAS: 158665-27-1

Molecular Formula: C42H61N2O5P

Molecular Weight: 704.93

Purity: >95% by HPLC

Appearance: Colorless oily matter

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Boiling Point: 702.3±60.0 °C at 760 mmHg

InChIKey: QZFCUJPRTWVAIA-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCCCCCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OCCC#N

IUPAC Name: 3-[12-[bis(4-methoxyphenyl)-phenylmethoxy]dodecoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H61N2O5P/c1-35(2)44(36(3)4)50(49-34-20-31-43)48-33-19-14-12-10-8-7-9-11-13-18-32-47-42(37-21-16-15-17-22-37,38-23-27-40(45-5)28-24-38)39-25-29-41(46-6)30-26-39/h15-17,21-30,35-36H,7-14,18-20,32-34H2,1-6H3

Synonyms: SPACER-C12 CEP; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 12-[bis(4-methoxyphenyl)phenylmethoxy]dodecyl 2-cyanoethyl ester; 12-(4,4'-Dimethoxytrityloxy)dodecyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 12-(Bis(4-methoxyphenyl)(phenyl)methoxy)dodecyl(2-cyanoethyl)diisopropyl phosphoramidite; Spacer Phosphoramidite C12; Spacer-C12 Phosphoramidite; Spacer C12 CEP hosphoramidite; C12 Spacer Amidite

TFA-Pentylaminolinker Phosphoramidite (BRP-02206)

Description: TFA-Pentylaminolinker Phosphoramidite is a specialized reagent used in the synthesis of oligonucleotides, particularly for introducing functional groups or linkers during automated DNA or RNA synthesis.

CAT: BRP-02206

CAS: 139747-14-1

Molecular Formula: C16H29F3N3O3P

Molecular Weight: 399.39

Purity: ≥97% by HPLC

Appearance: Liquid

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Storage: Store at -20 °C

Shipping: Dry ice

InChIKey: OVFVLUKVODOLBV-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCNC(=O)C(F)(F)F)OCCC#N

IUPAC Name: N-[5-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypentyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C16H29F3N3O3P/c1-13(2)22(14(3)4)26(25-12-8-9-20)24-11-7-5-6-10-21-15(23)16(17,18)19/h13-14H,5-8,10-12H2,1-4H3,(H,21,23)

Synonyms: 2-Cyanoethyl (5-(2,2,2-trifluoroacetamido)pentyl) diisopropylphosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 5-[(trifluoroacetyl)amino]pentyl ester

PC Linker Phosphoramidite (BRP-02207)

Description: PC Linker Phosphoramidite, a phosphoramidite compound, is used to incorporate photolytic linkages into oligonucleotides.

CAT: BRP-02207

CAS: 168329-40-6

Molecular Formula: C39H46N3O7P

Molecular Weight: 699.78

Purity: ≥95%

Appearance: Pale yellow foam

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Storage: Store at -20 °C

Symbol: PC Linker-CE Phosphoramidite

Shipping: Dry ice

InChIKey: KHOFWXQDBRVNMM-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(C=1C=CC=CC1N(=O)=O)CCOC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N(C(C)C)C(C)C

IUPAC Name: 3-(bis(4-methoxyphenyl)(phenyl)methoxy)-1-(2-nitrophenyl)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C39H46N3O7P/c1-29(2)41(30(3)4)50(48-27-12-26-40)49-38(36-15-10-11-16-37(36)42(43)44)25-28-47-39(31-13-8-7-9-14-31,32-17-21-34(45-5)22-18-32)33-19-23-35(46-6)24-20-33/h7-11,13-24,29-30,38H,12,25,27-28H2,1-6H3

Synonyms: 3-(4,4'-Dimethoxytrityl)-1-(2-nitrophenyl)-propan-1-yl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; PC linker CE Phoshphoramidite; 1-(O-Ph-NO2)-3-(DMTr)oxypropyl amidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 3-[bis(4-methoxyphenyl)phenylmethoxy]-1-(2-nitrophenyl)propyl 2-cyanoethyl ester; 3-[Bis(4-methoxyphenyl)phenylmethoxy]-1-(2-nitrophenyl)propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 3-[bis(4-methoxyphenyl)phenylmethoxy]-1-(2-nitrophenyl)propyl 2-cyanoethyl ester