What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

2'-F U Me-amidite

Description: 2'-F U Me-amidite is a phosphoramidite reagent used in the chemical synthesis of DNA oligonucleotides. This compound includes a 5'-O-DMTr protective group to safeguard the 5' hydroxyl group during synthesis, a 2'-fluorine modification to enhance stability against enzymatic degradation, and a 3'-methyl phosphoramidite for efficient incorporation into the growing DNA chain. This reagent is essential for creating modified DNA sequences with improved stability and integrity, suitable for various research and therapeutic applications.

CAT: BRP-01576

Molecular Formula: C37H45FN3O7P

Molecular Weight: 693.75

Purity: >95%

Appearance: Off-white solid

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InChIKey: XUSXWHAYFLUNDK-CGZUQJDWSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(C)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-methylphosphanyl]oxy-3-fluorooxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C37H45FN3O7P/c1-24(2)41(25(3)4)49(7)48-34-31(47-35(33(34)38)40-22-21-32(42)39-36(40)43)23-46-37(26-11-9-8-10-12-26,27-13-17-29(44-5)18-14-27)28-15-19-30(45-6)20-16-28/h8-22,24-25,31,33-35H,23H2,1-7H3,(H,39,42,43)/t31-,33-,34-,35-,49?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methyl-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-Methyl-phosphoramidite; 2'-F-dU-3'-Methyl-phosphoramidite; 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-F dU Me-amidite

2'-F C(Ac) Me-amidite

Description: 2'-F C(Ac) Me-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01577

Molecular Formula: C39H48FN4O7P

Molecular Weight: 734.81

Purity: >95%

Appearance: Off-white solid

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InChIKey: KBVMZEMFKQCECY-SGXIJWRWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C39H48FN4O7P/c1-25(2)44(26(3)4)52(8)51-36-33(50-37(35(36)40)43-23-22-34(41-27(5)45)42-38(43)46)24-49-39(28-12-10-9-11-13-28,29-14-18-31(47-6)19-15-29)30-16-20-32(48-7)21-17-30/h9-23,25-26,33,35-37H,24H2,1-8H3,(H,41,42,45,46)/t33-,35-,36-,37-,52?/m1/s1

Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-Methyl-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-Methyl-phosphoramidite; 2'-F-Ac-dC-3'-Methyl-phosphoramidite; 2'-F dC(Ac) Me-amidite; 2'-F cytidine (N-Ac) methyl phosphoramidite

2'-F A(Bz) Me-amidite

Description: 2'-F A(Bz) Me-amidite is a phosphoramidite reagent utilized in the synthesis of DNA oligonucleotides. This compound features a benzoyl group at the N6 position of the adenine base, providing protection during synthesis. The 5'-O-(4,4'-dimethoxytrityl) group shields the 5' hydroxyl group of the nucleoside, facilitating controlled assembly of the oligonucleotide chain. A fluorine atom at the 2' position of the deoxyribose sugar enhances the oligonucleotide's stability against enzymatic degradation. The 3'-methyl phosphoramidite moiety enables efficient coupling reactions for precise incorporation into DNA sequences, essential for various biomedical and genetic applications.

CAT: BRP-01578

Molecular Formula: C45H50FN6O6P

Molecular Weight: 820.90

Purity: >95%

Appearance: Off-white solid

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InChIKey: UCNMOPCADOGMJE-GBNBITQMSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C45H50FN6O6P/c1-29(2)52(30(3)4)59(7)58-40-37(57-44(38(40)46)51-28-49-39-41(47-27-48-42(39)51)50-43(53)31-14-10-8-11-15-31)26-56-45(32-16-12-9-13-17-32,33-18-22-35(54-5)23-19-33)34-20-24-36(55-6)25-21-34/h8-25,27-30,37-38,40,44H,26H2,1-7H3,(H,47,48,50,53)/t37-,38-,40-,44-,59?/m1/s1

Synonyms: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methyl-phosphoramidite; 5'-O-DMTr-2'-F-dA(Bz)-3'-methyl-phosphoramidite; 2'-F dA(Bz) Me-amidite; 2'-F adenosine (N-Bz) methyl phosphoramidite

2'-F G(iBu) Me-amidite

Description: 2'-F G(iBu) Me-amidite is a phosphoramidite reagent used in DNA oligonucleotide synthesis. It incorporates a modified guanine nucleotide with a fluorine atom at the 2' position of the sugar, enhancing stability against enzymatic degradation. The nucleoside is protected at the 5' position with a 4,4'-dimethoxytrityl group and at the N2 position with an isobutyryl group, facilitating controlled synthesis and modification of DNA sequences for diverse biological and therapeutic applications.

CAT: BRP-01579

Molecular Formula: C42H52FN6O7P

Molecular Weight: 802.88

Purity: >95%

Appearance: Off-white solid

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InChIKey: CCVHKDPSLDLLHS-CDTSKKGKSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C42H52FN6O7P/c1-25(2)38(50)46-41-45-37-35(39(51)47-41)44-24-48(37)40-34(43)36(56-57(9)49(26(3)4)27(5)6)33(55-40)23-54-42(28-13-11-10-12-14-28,29-15-19-31(52-7)20-16-29)30-17-21-32(53-8)22-18-30/h10-22,24-27,33-34,36,40H,23H2,1-9H3,(H2,45,46,47,50,51)/t33-,34-,36-,40-,57?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-methyl-phosphoramidite; 5'-O-DMTr-2'-F-dG(iBu)-3'-methyl-phosphoramidite; 2'-F dG(iBu) Me-amidite; 2'-F Guanosine (n-ibu) methyl phosphoramidite

ANA 2'-F MeC(Bz) amidite

Description: N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-β-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite is utilized in the synthesis of modified oligonucleotides to enhance their stability, binding affinity, and resistance to enzymatic degradation, making it a valuable tool for developing therapeutic nucleic acids, such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and processes in biochemical research.

CAT: BRP-01580

Molecular Formula: C47H53FN5O8P

Molecular Weight: 865.94

Purity: >95%

Appearance: Off-white solid

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InChIKey: XYPAFCMPDQWTME-MCYFHWMRSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

IUPAC Name: N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C47H53FN5O8P/c1-31(2)53(32(3)4)62(59-28-14-27-49)61-42-40(60-45(41(42)48)52-29-33(5)43(51-46(52)55)50-44(54)34-15-10-8-11-16-34)30-58-47(35-17-12-9-13-18-35,36-19-23-38(56-6)24-20-36)37-21-25-39(57-7)26-22-37/h8-13,15-26,29,31-32,40-42,45H,14,28,30H2,1-7H3,(H,50,51,54,55)/t40-,41+,42-,45-,62?/m1/s1

Synonyms: N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite; (2R,3R,4S,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-F N1-Methyl PseudoUridine amidite

Description: 2'-F N1-Methyl PseudoUridine amidite is employed in the solid-phase synthesis of modified oligonucleotides. It is a powerful tool in the synthesis of stable and effective modified oligonucleotides for research and therapeutic purposes.

CAT: BRP-01581

Molecular Formula: C40H48FN4O8P

Molecular Weight: 762.82

Purity: >95%

Appearance: Off-white solid

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InChIKey: VYDSFQVJLJFHSF-HRZVAZJQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C40H48FN4O8P/c1-26(2)45(27(3)4)54(51-23-11-22-42)53-37-34(52-36(35(37)41)33-24-44(5)39(47)43-38(33)46)25-50-40(28-12-9-8-10-13-28,29-14-18-31(48-6)19-15-29)30-16-20-32(49-7)21-17-30/h8-10,12-21,24,26-27,34-37H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35+,36+,37-,54?/m1/s1

Synonyms: N1-Me-5'-O-DMT-2'-fluoro-2'-Deoxy PseudoUridine 3'-CE phosphoramidite; 2'-F-N1-Me-pU amidite; 2'-Fluoro-N1-Me-pU-3'-phosphoramidite

2'-F C(Ac) OBn-amidite

Description: 2'-F C(Ac) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01582

Molecular Formula: C45H52FN4O8P

Molecular Weight: 826.90

Purity: >95%

Appearance: Off-white solid

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InChIKey: SHMALCARVZQMLW-ACVVKSTRSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl benzyl diisopropylphosphoramidite

InChI: InChI=1S/C45H52FN4O8P/c1-30(2)50(31(3)4)59(56-28-33-14-10-8-11-15-33)58-42-39(57-43(41(42)46)49-27-26-40(47-32(5)51)48-44(49)52)29-55-45(34-16-12-9-13-17-34,35-18-22-37(53-6)23-19-35)36-20-24-38(54-7)25-21-36/h8-27,30-31,39,41-43H,28-29H2,1-7H3,(H,47,48,51,52)/t39-,41-,42-,43-,59?/m1/s1

Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-benzyloxy-phosphoramidite; 2'-F-Ac-dC-3'-benzyloxy-phosphoramidite; 2'-F dC(Ac) OBn-amidite; 2'-F cytidine (N-Ac) benzyloxy phosphoramidite

2'-F A(Bz) OBn-amidite

Description: 2'-F A(Bz) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It enables the controlled synthesis of DNA oligonucleotides with modified adenine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01583

Molecular Formula: C51H54FN6O7P

Molecular Weight: 913.00

Purity: >95%

Appearance: Off-white solid

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InChIKey: DULYHLZNELEDNC-RLRGUIIOSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl benzyl diisopropylphosphoramidite

InChI: InChI=1S/C51H54FN6O7P/c1-34(2)58(35(3)4)66(63-30-36-16-10-7-11-17-36)65-46-43(64-50(44(46)52)57-33-55-45-47(53-32-54-48(45)57)56-49(59)37-18-12-8-13-19-37)31-62-51(38-20-14-9-15-21-38,39-22-26-41(60-5)27-23-39)40-24-28-42(61-6)29-25-40/h7-29,32-35,43-44,46,50H,30-31H2,1-6H3,(H,53,54,56,59)/t43-,44-,46-,50-,66?/m1/s1

Synonyms: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dA(Bz)-3'-benzyloxy-phosphoramidite; 2'-F dA(Bz) OBn-amidite; 2'-F adenosine (N-Bz) benzyloxy phosphoramidite

2'-F G(iBu) OBn-amidite

Description: 2'-F G(iBu) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It facilitates the controlled synthesis of DNA oligonucleotides with modified guanosine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01584

Molecular Formula: C48H56FN6O8P

Molecular Weight: 894.98

Purity: >95%

Appearance: Off-white solid

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InChIKey: NMMXCYLXXJOCAP-AUNSQTKWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C48H56FN6O8P/c1-30(2)44(56)52-47-51-43-41(45(57)53-47)50-29-54(43)46-40(49)42(63-64(55(31(3)4)32(5)6)61-27-33-15-11-9-12-16-33)39(62-46)28-60-48(34-17-13-10-14-18-34,35-19-23-37(58-7)24-20-35)36-21-25-38(59-8)26-22-36/h9-26,29-32,39-40,42,46H,27-28H2,1-8H3,(H2,51,52,53,56,57)/t39-,40-,42-,46-,64?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dG(iBu)-3'-benzyloxy-phosphoramidite; 2'-F dG(iBu) OBn-amidite; 2'-F Guanosine (n-ibu) benzyloxy phosphoramidite

2'-F U OBn-amidite

Description: 2'-F U OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified uridine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01585

Molecular Formula: C43H49FN3O8P

Molecular Weight: 785.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: LXSZAXFOUHFKJS-APEVFGHTSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C43H49FN3O8P/c1-29(2)47(30(3)4)56(53-27-31-13-9-7-10-14-31)55-40-37(54-41(39(40)44)46-26-25-38(48)45-42(46)49)28-52-43(32-15-11-8-12-16-32,33-17-21-35(50-5)22-18-33)34-19-23-36(51-6)24-20-34/h7-26,29-30,37,39-41H,27-28H2,1-6H3,(H,45,48,49)/t37-,39-,40-,41-,56?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-benzyloxy-phosphoramidite; 2'-F-dU-3'-benzyloxy-phosphoramidite; 2'-F dU OBn-amidite

2'-F G(iBu) (TBSO)SATE-amidite

Description: 2'-F G(iBu) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It facilitates the controlled synthesis of DNA oligonucleotides with modified guanosine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01586

Molecular Formula: C54H76FN6O10PSSi

Molecular Weight: 1079.36

Purity: >95%

Appearance: Off-white solid

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InChIKey: AJSNCSZUDGUTOZ-WFDCMRDWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C54H76FN6O10PSSi/c1-34(2)47(62)58-51-57-46-44(48(63)59-51)56-33-60(46)49-43(55)45(71-72(61(35(3)4)36(5)6)68-29-30-73-50(64)53(10,11)32-69-74(14,15)52(7,8)9)42(70-49)31-67-54(37-19-17-16-18-20-37,38-21-25-40(65-12)26-22-38)39-23-27-41(66-13)28-24-39/h16-28,33-36,42-43,45,49H,29-32H2,1-15H3,(H2,57,58,59,62,63)/t42-,43-,45-,49-,72?/m1/s1

Synonyms: 2'-F dG(iBu) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Guanosine (N-iBu) 3'-O-(TBSO)SATE phosphoramidite

2'-F A(Bz) (TBSO)SATE-amidite

Description: 2'-F A(Bz) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It enables the controlled synthesis of DNA oligonucleotides with modified adenine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01587

Molecular Formula: C57H74FN6O9PSSi

Molecular Weight: 1097.38

Purity: >95%

Appearance: Off-white solid

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InChIKey: PBYQXESREXFRID-RONWHNMCSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C57H74FN6O9PSSi/c1-38(2)64(39(3)4)74(70-32-33-75-54(66)56(8,9)35-71-76(12,13)55(5,6)7)73-49-46(72-53(47(49)58)63-37-61-48-50(59-36-60-51(48)63)62-52(65)40-20-16-14-17-21-40)34-69-57(41-22-18-15-19-23-41,42-24-28-44(67-10)29-25-42)43-26-30-45(68-11)31-27-43/h14-31,36-39,46-47,49,53H,32-35H2,1-13H3,(H,59,60,62,65)/t46-,47-,49-,53-,74?/m1/s1

Synonyms: 2'-F dA(Bz) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Adenosine (N-Bz) 3'-O-(TBSO)SATE phosphoramidite

2'-F C(Bz) (TBSO)SATE-amidite

Description: 2'-F C(Bz) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01588

Molecular Formula: C56H74FN4O10PSSi

Molecular Weight: 1073.35

Purity: >95%

Appearance: Off-white solid

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InChIKey: HVBZXHBXPNTSPC-CEJOASKFSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C56H74FN4O10PSSi/c1-38(2)61(39(3)4)72(68-34-35-73-52(63)55(8,9)37-69-74(12,13)54(5,6)7)71-49-46(70-51(48(49)57)60-33-32-47(59-53(60)64)58-50(62)40-20-16-14-17-21-40)36-67-56(41-22-18-15-19-23-41,42-24-28-44(65-10)29-25-42)43-26-30-45(66-11)31-27-43/h14-33,38-39,46,48-49,51H,34-37H2,1-13H3,(H,58,59,62,64)/t46-,48-,49-,51-,72?/m1/s1

Synonyms: 2'-F dC(Bz) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Cytidine (N-Bz) 3'-O-(TBSO)SATE phosphoramidite

2'-F U (TBSO)SATE-amidite

Description: 2'-F U (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified uridine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01589

Molecular Formula: C49H69FN3O10PSSi

Molecular Weight: 970.23

Purity: >95%

Appearance: Off-white solid

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InChIKey: JADSOFLFIWRFSE-JISWKONASA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C49H69FN3O10PSSi/c1-33(2)53(34(3)4)64(60-29-30-65-45(55)48(8,9)32-61-66(12,13)47(5,6)7)63-43-40(62-44(42(43)50)52-28-27-41(54)51-46(52)56)31-59-49(35-17-15-14-16-18-35,36-19-23-38(57-10)24-20-36)37-21-25-39(58-11)26-22-37/h14-28,33-34,40,42-44H,29-32H2,1-13H3,(H,51,54,56)/t40-,42-,43-,44-,64?/m1/s1

Synonyms: 2'-F dU (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Uridine 3'-O-(TBSO)SATE phosphoramidite

2'-F U Obutyn-amidite

CAT: BRP-01590

CAS: 1840885-37-1

Molecular Formula: C40H47FN3O8P

Molecular Weight: 747.80

Purity: >95%

Appearance: Off-white solid

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InChIKey: MXTGLMKXIAYCPR-GFIGKZKCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCCC#C)N(C(C)C)C(C)C)C2F

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C40H47FN3O8P/c1-8-9-25-50-53(44(27(2)3)28(4)5)52-37-34(51-38(36(37)41)43-24-23-35(45)42-39(43)46)26-49-40(29-13-11-10-12-14-29,30-15-19-32(47-6)20-16-30)31-17-21-33(48-7)22-18-31/h1,10-24,27-28,34,36-38H,9,25-26H2,2-7H3,(H,42,45,46)/t34-,36-,37-,38-,53?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]; 2'-F dU Obutyn-amidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Obutyn-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-Obutyn-phosphoramidite

2'-F C(Ac) Obutyn-amidite

Description: 2'-F C(Ac) Obutyn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01591

CAS: 1840885-72-4

Molecular Formula: C42H50FN4O8P

Molecular Weight: 788.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: PPGHLCKGBCZDSW-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCCC#C)N(C(C)C)C(C)C)C2F)NC(=O)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C42H50FN4O8P/c1-9-10-26-53-56(47(28(2)3)29(4)5)55-39-36(54-40(38(39)43)46-25-24-37(44-30(6)48)45-41(46)49)27-52-42(31-14-12-11-13-15-31,32-16-20-34(50-7)21-17-32)33-18-22-35(51-8)23-19-33/h1,11-25,28-29,36,38-40H,10,26-27H2,2-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]; 2'-F dC(Ac) Obutyn-amidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-Obutyn-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-Obutyn-phosphoramidite

2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent crucial in the synthesis of modified nucleic acids. This compound is designed to introduce a modified cytidine nucleoside into oligonucleotide sequences with enhanced stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis platforms, facilitating precise and reliable incorporation of modified nucleotides into sequence-defined oligonucleotides. This capability is instrumental in various biomedical research applications, including gene therapy, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids offer improved stability, specificity, and functionality.

CAT: BRP-01596

Molecular Formula: C52H64FN4O11PS

Molecular Weight: 1003.13

Purity: ≥95%

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InChIKey: ZACCDKZIIHZEBP-YDKKORBQSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C52H64FN4O11PS/c1-35(2)50(59)70-32-31-63-29-30-66-69(57(36(3)4)37(5)6)68-48-44(67-49(47(48)53)56-28-27-45(55-51(56)60)54-46(58)34-64-43-17-13-10-14-18-43)33-65-52(38-15-11-9-12-16-38,39-19-23-41(61-7)24-20-39)40-21-25-42(62-8)26-22-40/h9-28,35-37,44,47-49H,29-34H2,1-8H3,(H,54,55,58,60)/t44-,47-,48-,49-,69?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dC(Pac)-3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. This compound is specifically designed to incorporate a modified guanosine nucleoside into oligonucleotide sequences, enhancing their stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis platforms, facilitating precise and reliable incorporation of modified nucleotides into sequence-defined oligonucleotides. This capability is crucial in various biomedical research applications, including gene editing, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids provide improved stability, specificity, and functionality.

CAT: BRP-01597

Molecular Formula: C56H70FN6O11PS

Molecular Weight: 1085.24

Purity: ≥95%

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InChIKey: YCAKSFKUVSLOLZ-IUVNWIHYSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C56H70FN6O11PS/c1-35(2)39-16-22-45(23-17-39)70-33-47(64)59-55-60-51-49(52(65)61-55)58-34-62(51)53-48(57)50(74-75(63(37(5)6)38(7)8)72-29-28-69-30-31-76-54(66)36(3)4)46(73-53)32-71-56(40-14-12-11-13-15-40,41-18-24-43(67-9)25-19-41)42-20-26-44(68-10)27-21-42/h11-27,34-38,46,48,50,53H,28-33H2,1-10H3,(H2,59,60,61,64,65)/t46-,48-,50-,53-,75?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dG(iPr-Pac)-3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Uridine 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Uridine 3'-O-BMEG phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids, specifically incorporating a modified uridine nucleoside into oligonucleotide sequences. It facilitates the synthesis of nucleic acids with enhanced stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis, enabling precise incorporation of modified uridine nucleotides into sequence-defined oligonucleotides. This capability supports various biomedical research applications, including gene therapy, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids offer improved performance in terms of stability, specificity, and functionality.

CAT: BRP-01598

CAS: 1219597-57-5

Molecular Formula: C44H57FN3O10PS

Molecular Weight: 869.98

Purity: ≥95%

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InChIKey: MQTFINZTMLJCIH-KVTBCOQSSA-N

CanonicalSMILES: CC(C)C(=O)SCCOCCOP(N(C(C)C)C(C)C)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: S-[2-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethyl] 2-methylpropanethioate

InChI: InChI=1S/C44H57FN3O10PS/c1-29(2)42(50)60-27-26-54-24-25-56-59(48(30(3)4)31(5)6)58-40-37(57-41(39(40)45)47-23-22-38(49)46-43(47)51)28-55-44(32-12-10-9-11-13-32,33-14-18-35(52-7)19-15-33)34-16-20-36(53-8)21-17-34/h9-23,29-31,37,39-41H,24-28H2,1-8H3,(H,46,49,51)/t37-,39-,40-,41-,59?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dU-3'-O-BMEG phosphoramidite; S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-[2-[(2-methyl-1-oxopropyl)thio]ethoxy]ethyl N,N-bis(1-methylethyl)phosphoramidite]

2'-Fluoro-2'-deoxy Adenosine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Adenosine (N-PAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids, specifically designed to incorporate a modified adenosine nucleoside into oligonucleotide sequences. It serves as an intermediate in automated DNA and RNA synthesis platforms. This reagent is essential in biomedical research applications such as gene editing, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids are utilized for improved stability, specificity, and functional properties.

CAT: BRP-01599

Molecular Formula: C53H64FN6O10PS

Molecular Weight: 1027.15

Purity: ≥95%

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InChIKey: ULXOJEKGELECAK-BIRYJSLWSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C53H64FN6O10PS/c1-35(2)52(62)72-30-29-65-27-28-68-71(60(36(3)4)37(5)6)70-48-44(31-67-53(38-15-11-9-12-16-38,39-19-23-41(63-7)24-20-39)40-21-25-42(64-8)26-22-40)69-51(46(48)54)59-34-57-47-49(55-33-56-50(47)59)58-45(61)32-66-43-17-13-10-14-18-43/h9-26,33-37,44,46,48,51H,27-32H2,1-8H3,(H,55,56,58,61)/t44-,46-,48-,51-,71?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dA(Pac)-3'-O-BMEG phosphoramidite