Phosphoramidites

ANA 2'-F MeC(Bz) amidite

Description: N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-β-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite is utilized in the synthesis of modified oligonucleotides to enhance their stability, binding affinity, and resistance to enzymatic degradation, making it a valuable tool for developing therapeutic nucleic acids, such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and processes in biochemical research.

CAT: BRP-01580

Molecular Formula: C47H53FN5O8P

Molecular Weight: 865.94

Purity: >95%

Appearance: Off-white solid

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InChIKey: XYPAFCMPDQWTME-MCYFHWMRSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

IUPAC Name: N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C47H53FN5O8P/c1-31(2)53(32(3)4)62(59-28-14-27-49)61-42-40(60-45(41(42)48)52-29-33(5)43(51-46(52)55)50-44(54)34-15-10-8-11-16-34)30-58-47(35-17-12-9-13-18-35,36-19-23-38(56-6)24-20-36)37-21-25-39(57-7)26-22-37/h8-13,15-26,29,31-32,40-42,45H,14,28,30H2,1-7H3,(H,50,51,54,55)/t40-,41+,42-,45-,62?/m1/s1

Synonyms: N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite; (2R,3R,4S,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-F N1-Methyl PseudoUridine amidite

Description: 2'-F N1-Methyl PseudoUridine amidite is employed in the solid-phase synthesis of modified oligonucleotides. It is a powerful tool in the synthesis of stable and effective modified oligonucleotides for research and therapeutic purposes.

CAT: BRP-01581

Molecular Formula: C40H48FN4O8P

Molecular Weight: 762.82

Purity: >95%

Appearance: Off-white solid

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InChIKey: VYDSFQVJLJFHSF-HRZVAZJQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C40H48FN4O8P/c1-26(2)45(27(3)4)54(51-23-11-22-42)53-37-34(52-36(35(37)41)33-24-44(5)39(47)43-38(33)46)25-50-40(28-12-9-8-10-13-28,29-14-18-31(48-6)19-15-29)30-16-20-32(49-7)21-17-30/h8-10,12-21,24,26-27,34-37H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35+,36+,37-,54?/m1/s1

Synonyms: N1-Me-5'-O-DMT-2'-fluoro-2'-Deoxy PseudoUridine 3'-CE phosphoramidite; 2'-F-N1-Me-pU amidite; 2'-Fluoro-N1-Me-pU-3'-phosphoramidite

2'-F C(Ac) OBn-amidite

Description: 2'-F C(Ac) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01582

Molecular Formula: C45H52FN4O8P

Molecular Weight: 826.90

Purity: >95%

Appearance: Off-white solid

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InChIKey: SHMALCARVZQMLW-ACVVKSTRSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl benzyl diisopropylphosphoramidite

InChI: InChI=1S/C45H52FN4O8P/c1-30(2)50(31(3)4)59(56-28-33-14-10-8-11-15-33)58-42-39(57-43(41(42)46)49-27-26-40(47-32(5)51)48-44(49)52)29-55-45(34-16-12-9-13-17-34,35-18-22-37(53-6)23-19-35)36-20-24-38(54-7)25-21-36/h8-27,30-31,39,41-43H,28-29H2,1-7H3,(H,47,48,51,52)/t39-,41-,42-,43-,59?/m1/s1

Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-benzyloxy-phosphoramidite; 2'-F-Ac-dC-3'-benzyloxy-phosphoramidite; 2'-F dC(Ac) OBn-amidite; 2'-F cytidine (N-Ac) benzyloxy phosphoramidite

2'-F A(Bz) OBn-amidite

Description: 2'-F A(Bz) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It enables the controlled synthesis of DNA oligonucleotides with modified adenine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01583

Molecular Formula: C51H54FN6O7P

Molecular Weight: 913.00

Purity: >95%

Appearance: Off-white solid

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InChIKey: DULYHLZNELEDNC-RLRGUIIOSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl benzyl diisopropylphosphoramidite

InChI: InChI=1S/C51H54FN6O7P/c1-34(2)58(35(3)4)66(63-30-36-16-10-7-11-17-36)65-46-43(64-50(44(46)52)57-33-55-45-47(53-32-54-48(45)57)56-49(59)37-18-12-8-13-19-37)31-62-51(38-20-14-9-15-21-38,39-22-26-41(60-5)27-23-39)40-24-28-42(61-6)29-25-40/h7-29,32-35,43-44,46,50H,30-31H2,1-6H3,(H,53,54,56,59)/t43-,44-,46-,50-,66?/m1/s1

Synonyms: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dA(Bz)-3'-benzyloxy-phosphoramidite; 2'-F dA(Bz) OBn-amidite; 2'-F adenosine (N-Bz) benzyloxy phosphoramidite

2'-F G(iBu) OBn-amidite

Description: 2'-F G(iBu) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It facilitates the controlled synthesis of DNA oligonucleotides with modified guanosine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01584

Molecular Formula: C48H56FN6O8P

Molecular Weight: 894.98

Purity: >95%

Appearance: Off-white solid

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InChIKey: NMMXCYLXXJOCAP-AUNSQTKWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C48H56FN6O8P/c1-30(2)44(56)52-47-51-43-41(45(57)53-47)50-29-54(43)46-40(49)42(63-64(55(31(3)4)32(5)6)61-27-33-15-11-9-12-16-33)39(62-46)28-60-48(34-17-13-10-14-18-34,35-19-23-37(58-7)24-20-35)36-21-25-38(59-8)26-22-36/h9-26,29-32,39-40,42,46H,27-28H2,1-8H3,(H2,51,52,53,56,57)/t39-,40-,42-,46-,64?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dG(iBu)-3'-benzyloxy-phosphoramidite; 2'-F dG(iBu) OBn-amidite; 2'-F Guanosine (n-ibu) benzyloxy phosphoramidite

2'-F U OBn-amidite

Description: 2'-F U OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified uridine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01585

Molecular Formula: C43H49FN3O8P

Molecular Weight: 785.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: LXSZAXFOUHFKJS-APEVFGHTSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C43H49FN3O8P/c1-29(2)47(30(3)4)56(53-27-31-13-9-7-10-14-31)55-40-37(54-41(39(40)44)46-26-25-38(48)45-42(46)49)28-52-43(32-15-11-8-12-16-32,33-17-21-35(50-5)22-18-33)34-19-23-36(51-6)24-20-34/h7-26,29-30,37,39-41H,27-28H2,1-6H3,(H,45,48,49)/t37-,39-,40-,41-,56?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-benzyloxy-phosphoramidite; 2'-F-dU-3'-benzyloxy-phosphoramidite; 2'-F dU OBn-amidite

2'-F G(iBu) (TBSO)SATE-amidite

Description: 2'-F G(iBu) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It facilitates the controlled synthesis of DNA oligonucleotides with modified guanosine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01586

Molecular Formula: C54H76FN6O10PSSi

Molecular Weight: 1079.36

Purity: >95%

Appearance: Off-white solid

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InChIKey: AJSNCSZUDGUTOZ-WFDCMRDWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C54H76FN6O10PSSi/c1-34(2)47(62)58-51-57-46-44(48(63)59-51)56-33-60(46)49-43(55)45(71-72(61(35(3)4)36(5)6)68-29-30-73-50(64)53(10,11)32-69-74(14,15)52(7,8)9)42(70-49)31-67-54(37-19-17-16-18-20-37,38-21-25-40(65-12)26-22-38)39-23-27-41(66-13)28-24-39/h16-28,33-36,42-43,45,49H,29-32H2,1-15H3,(H2,57,58,59,62,63)/t42-,43-,45-,49-,72?/m1/s1

Synonyms: 2'-F dG(iBu) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Guanosine (N-iBu) 3'-O-(TBSO)SATE phosphoramidite

2'-F A(Bz) (TBSO)SATE-amidite

Description: 2'-F A(Bz) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It enables the controlled synthesis of DNA oligonucleotides with modified adenine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01587

Molecular Formula: C57H74FN6O9PSSi

Molecular Weight: 1097.38

Purity: >95%

Appearance: Off-white solid

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InChIKey: PBYQXESREXFRID-RONWHNMCSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C57H74FN6O9PSSi/c1-38(2)64(39(3)4)74(70-32-33-75-54(66)56(8,9)35-71-76(12,13)55(5,6)7)73-49-46(72-53(47(49)58)63-37-61-48-50(59-36-60-51(48)63)62-52(65)40-20-16-14-17-21-40)34-69-57(41-22-18-15-19-23-41,42-24-28-44(67-10)29-25-42)43-26-30-45(68-11)31-27-43/h14-31,36-39,46-47,49,53H,32-35H2,1-13H3,(H,59,60,62,65)/t46-,47-,49-,53-,74?/m1/s1

Synonyms: 2'-F dA(Bz) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Adenosine (N-Bz) 3'-O-(TBSO)SATE phosphoramidite

2'-F C(Bz) (TBSO)SATE-amidite

Description: 2'-F C(Bz) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01588

Molecular Formula: C56H74FN4O10PSSi

Molecular Weight: 1073.35

Purity: >95%

Appearance: Off-white solid

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InChIKey: HVBZXHBXPNTSPC-CEJOASKFSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C56H74FN4O10PSSi/c1-38(2)61(39(3)4)72(68-34-35-73-52(63)55(8,9)37-69-74(12,13)54(5,6)7)71-49-46(70-51(48(49)57)60-33-32-47(59-53(60)64)58-50(62)40-20-16-14-17-21-40)36-67-56(41-22-18-15-19-23-41,42-24-28-44(65-10)29-25-42)43-26-30-45(66-11)31-27-43/h14-33,38-39,46,48-49,51H,34-37H2,1-13H3,(H,58,59,62,64)/t46-,48-,49-,51-,72?/m1/s1

Synonyms: 2'-F dC(Bz) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Cytidine (N-Bz) 3'-O-(TBSO)SATE phosphoramidite

2'-F U (TBSO)SATE-amidite

Description: 2'-F U (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified uridine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01589

Molecular Formula: C49H69FN3O10PSSi

Molecular Weight: 970.23

Purity: >95%

Appearance: Off-white solid

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InChIKey: JADSOFLFIWRFSE-JISWKONASA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C49H69FN3O10PSSi/c1-33(2)53(34(3)4)64(60-29-30-65-45(55)48(8,9)32-61-66(12,13)47(5,6)7)63-43-40(62-44(42(43)50)52-28-27-41(54)51-46(52)56)31-59-49(35-17-15-14-16-18-35,36-19-23-38(57-10)24-20-36)37-21-25-39(58-11)26-22-37/h14-28,33-34,40,42-44H,29-32H2,1-13H3,(H,51,54,56)/t40-,42-,43-,44-,64?/m1/s1

Synonyms: 2'-F dU (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Uridine 3'-O-(TBSO)SATE phosphoramidite

2'-F U Obutyn-amidite

CAT: BRP-01590

CAS: 1840885-37-1

Molecular Formula: C40H47FN3O8P

Molecular Weight: 747.80

Purity: >95%

Appearance: Off-white solid

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InChIKey: MXTGLMKXIAYCPR-GFIGKZKCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCCC#C)N(C(C)C)C(C)C)C2F

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C40H47FN3O8P/c1-8-9-25-50-53(44(27(2)3)28(4)5)52-37-34(51-38(36(37)41)43-24-23-35(45)42-39(43)46)26-49-40(29-13-11-10-12-14-29,30-15-19-32(47-6)20-16-30)31-17-21-33(48-7)22-18-31/h1,10-24,27-28,34,36-38H,9,25-26H2,2-7H3,(H,42,45,46)/t34-,36-,37-,38-,53?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]; 2'-F dU Obutyn-amidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Obutyn-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-Obutyn-phosphoramidite

2'-F C(Ac) Obutyn-amidite

Description: 2'-F C(Ac) Obutyn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01591

CAS: 1840885-72-4

Molecular Formula: C42H50FN4O8P

Molecular Weight: 788.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: PPGHLCKGBCZDSW-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCCC#C)N(C(C)C)C(C)C)C2F)NC(=O)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C42H50FN4O8P/c1-9-10-26-53-56(47(28(2)3)29(4)5)55-39-36(54-40(38(39)43)46-25-24-37(44-30(6)48)45-41(46)49)27-52-42(31-14-12-11-13-15-31,32-16-20-34(50-7)21-17-32)33-18-22-35(51-8)23-19-33/h1,11-25,28-29,36,38-40H,10,26-27H2,2-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]; 2'-F dC(Ac) Obutyn-amidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-Obutyn-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-Obutyn-phosphoramidite

2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent crucial in the synthesis of modified nucleic acids. This compound is designed to introduce a modified cytidine nucleoside into oligonucleotide sequences with enhanced stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis platforms, facilitating precise and reliable incorporation of modified nucleotides into sequence-defined oligonucleotides. This capability is instrumental in various biomedical research applications, including gene therapy, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids offer improved stability, specificity, and functionality.

CAT: BRP-01596

Molecular Formula: C52H64FN4O11PS

Molecular Weight: 1003.13

Purity: ≥95%

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InChIKey: ZACCDKZIIHZEBP-YDKKORBQSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C52H64FN4O11PS/c1-35(2)50(59)70-32-31-63-29-30-66-69(57(36(3)4)37(5)6)68-48-44(67-49(47(48)53)56-28-27-45(55-51(56)60)54-46(58)34-64-43-17-13-10-14-18-43)33-65-52(38-15-11-9-12-16-38,39-19-23-41(61-7)24-20-39)40-21-25-42(62-8)26-22-40/h9-28,35-37,44,47-49H,29-34H2,1-8H3,(H,54,55,58,60)/t44-,47-,48-,49-,69?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dC(Pac)-3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. This compound is specifically designed to incorporate a modified guanosine nucleoside into oligonucleotide sequences, enhancing their stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis platforms, facilitating precise and reliable incorporation of modified nucleotides into sequence-defined oligonucleotides. This capability is crucial in various biomedical research applications, including gene editing, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids provide improved stability, specificity, and functionality.

CAT: BRP-01597

Molecular Formula: C56H70FN6O11PS

Molecular Weight: 1085.24

Purity: ≥95%

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InChIKey: YCAKSFKUVSLOLZ-IUVNWIHYSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C56H70FN6O11PS/c1-35(2)39-16-22-45(23-17-39)70-33-47(64)59-55-60-51-49(52(65)61-55)58-34-62(51)53-48(57)50(74-75(63(37(5)6)38(7)8)72-29-28-69-30-31-76-54(66)36(3)4)46(73-53)32-71-56(40-14-12-11-13-15-40,41-18-24-43(67-9)25-19-41)42-20-26-44(68-10)27-21-42/h11-27,34-38,46,48,50,53H,28-33H2,1-10H3,(H2,59,60,61,64,65)/t46-,48-,50-,53-,75?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dG(iPr-Pac)-3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Uridine 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Uridine 3'-O-BMEG phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids, specifically incorporating a modified uridine nucleoside into oligonucleotide sequences. It facilitates the synthesis of nucleic acids with enhanced stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis, enabling precise incorporation of modified uridine nucleotides into sequence-defined oligonucleotides. This capability supports various biomedical research applications, including gene therapy, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids offer improved performance in terms of stability, specificity, and functionality.

CAT: BRP-01598

CAS: 1219597-57-5

Molecular Formula: C44H57FN3O10PS

Molecular Weight: 869.98

Purity: ≥95%

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InChIKey: MQTFINZTMLJCIH-KVTBCOQSSA-N

CanonicalSMILES: CC(C)C(=O)SCCOCCOP(N(C(C)C)C(C)C)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: S-[2-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethyl] 2-methylpropanethioate

InChI: InChI=1S/C44H57FN3O10PS/c1-29(2)42(50)60-27-26-54-24-25-56-59(48(30(3)4)31(5)6)58-40-37(57-41(39(40)45)47-23-22-38(49)46-43(47)51)28-55-44(32-12-10-9-11-13-32,33-14-18-35(52-7)19-15-33)34-16-20-36(53-8)21-17-34/h9-23,29-31,37,39-41H,24-28H2,1-8H3,(H,46,49,51)/t37-,39-,40-,41-,59?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dU-3'-O-BMEG phosphoramidite; S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-[2-[(2-methyl-1-oxopropyl)thio]ethoxy]ethyl N,N-bis(1-methylethyl)phosphoramidite]

2'-Fluoro-2'-deoxy Adenosine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Adenosine (N-PAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids, specifically designed to incorporate a modified adenosine nucleoside into oligonucleotide sequences. It serves as an intermediate in automated DNA and RNA synthesis platforms. This reagent is essential in biomedical research applications such as gene editing, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids are utilized for improved stability, specificity, and functional properties.

CAT: BRP-01599

Molecular Formula: C53H64FN6O10PS

Molecular Weight: 1027.15

Purity: ≥95%

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InChIKey: ULXOJEKGELECAK-BIRYJSLWSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C53H64FN6O10PS/c1-35(2)52(62)72-30-29-65-27-28-68-71(60(36(3)4)37(5)6)70-48-44(31-67-53(38-15-11-9-12-16-38,39-19-23-41(63-7)24-20-39)40-21-25-42(64-8)26-22-40)69-51(46(48)54)59-34-57-47-49(55-33-56-50(47)59)58-45(61)32-66-43-17-13-10-14-18-43/h9-26,33-37,44,46,48,51H,27-32H2,1-8H3,(H,55,56,58,61)/t44-,46-,48-,51-,71?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dA(Pac)-3'-O-BMEG phosphoramidite

5-O-DMTr-1-O-Ac-2-F-2-deoxyribofuranose-3-CE-Phosphoramidite

Description: 5-O-DMTr-1-O-Ac-2-F-2-deoxyribofuranose-3-CE-Phosphoramidite is a phosphoramidite reagent used in oligonucleotide synthesis. It features a deoxyribose sugar with specific modifications: the 5'-hydroxyl group is protected by a dimethoxytrityl (DMTr) group, the 1'-hydroxyl group is acetylated (Ac), and a fluorine atom is substituted at the 2' position. These modifications enhance the stability and functionality of the nucleic acids. The 3'-cyanoethyl (CE) phosphoramidite group is crucial for the automated synthesis process, enabling efficient and precise addition of this modified sugar to the growing oligonucleotide chain. This reagent is valuable in the synthesis of stable and functional nucleic acid sequences for various research and therapeutic applications.

CAT: BRP-01606

Molecular Formula: C37H46FN2O8P

Molecular Weight: 696.75

Purity: ≥95% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: YXVIYDHRSOENQP-NDCODMSPSA-N

IUPAC Name: (3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl acetate

InChI: InChI=1S/C37H46FN2O8P/c1-25(2)40(26(3)4)49(45-23-11-22-39)48-35-33(47-36(34(35)38)46-27(5)41)24-44-37(28-12-9-8-10-13-28,29-14-18-31(42-6)19-15-29)30-16-20-32(43-7)21-17-30/h8-10,12-21,25-26,33-36H,11,23-24H2,1-7H3/t33-,34-,35-,36?,49?/m1/s1

Synonyms: 5-O-(4,4'-Dimethoxytrityl)-1-O-acetyl-2-fluoro-2-deoxyribofuranose-3-cyanoethyl Phosphoramidite

5-DMTr-2-F-1,2-dideoxyribose-3-CE-Phosphoramidite

Description: 5-DMTr-2-F-1,2-dideoxyribose-3-CE-Phosphoramidite is a key reagent in the synthesis of modified oligonucleotides, featuring a dideoxyribose sugar with a 5'-dimethoxytrityl (DMTr) protective group and a fluorine atom at the 2' position. The dideoxyribose lacks hydroxyl groups at both the 1' and 2' positions, except for the 3'-hydroxyl, which is modified with a cyanoethyl (CE) phosphoramidite group. This design increases the stability of the oligonucleotide and prevents chain extension at the 2' position. This reagent is particularly useful for creating stable, modified oligonucleotides for use in various molecular biology and therapeutic applications.

CAT: BRP-01607

Molecular Formula: C35H44FN2O6P

Molecular Weight: 638.72

Purity: ≥98% by HPLC

Appearance: White or off-white to faint yellow solid

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InChIKey: CYNXGQPRPXHCQI-PRVDSXFMSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(COC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)F

IUPAC Name: 3-[[(2R,3R,4S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C35H44FN2O6P/c1-25(2)38(26(3)4)45(43-22-10-21-37)44-34-32(36)23-41-33(34)24-42-35(27-11-8-7-9-12-27,28-13-17-30(39-5)18-14-28)29-15-19-31(40-6)20-16-29/h7-9,11-20,25-26,32-34H,10,22-24H2,1-6H3/t32-,33+,34-,45?/m0/s1

Synonyms: 5-O-(4,4'-Dimethoxytrityl)-2-fluoro-1-deoxyribose-3-cyanoethyl Phosphoramidite; (2R,3R,4S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

3'-F-3'-dA(Bz)-2'-phosphoramidite

Description: 3'-F-3'-dA(Bz)-2'-phosphoramidite, an indispensable compound widely employed in the biomedical sector for the synthesis of oligonucleotides and nucleic acid analogs, holds paramount importance. Its modified structure renders it adept at enhancing stability, selectivity, and binding properties.

CAT: BRP-01609

CAS: 2127174-09-6

Molecular Formula: C47H51FN7O7P

Molecular Weight: 875.92

Purity: ≥95%

Appearance: Off-white solid

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InChIKey: WTXSTLCSPVTJTM-MSIRFHFKSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)F

IUPAC Name: (2R,3S,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-40(48)39(61-46(42)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1

Synonyms: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-deoxy-3'-fluoroadenosine-2'-CED-phosphoramidite; N-[9-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-fluorooxolan-2-yl]purin-6-yl]benzamide; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-3'-deoxy-3'-fluoroadenosine; 5'-DMT-3'-fluoro-DA(BZ) amidite; 3'-F A(Bz) 2'-amidite

Cholesterol C6 amine amidite (BRP-01617)

Description: Cholesterol C6 amine amidite is a powerful substance that functions to combat hypercholesterolemia and various lipid disorders. Using innovative technology, it works to inhibit cholesterol synthesis in the liver, leading to the reduction of overall blood cholesterol levels. Due to its notable and demonstrated effectiveness, it is highly regarded and widely employed within the biopharmaceutical industry in the treatment of cardiovascular diseases.

CAT: BRP-01617

CAS: 143723-64-2

Molecular Formula: C43H76N3O4P

Molecular Weight: 730.07

Purity: >95%

Appearance: Light-yellow oily matter

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Boiling Point: 722.5±60.0 °C at 760 mmHg

InChIKey: LLDRAIRYAJXEEP-CRQKJHHESA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)NCCCCCCOP(N(C(C)C)C(C)C)OCCC#N)C)C

IUPAC Name: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]carbamate

InChI: InChI=1S/C43H76N3O4P/c1-31(2)16-14-17-34(7)38-20-21-39-37-19-18-35-30-36(22-24-42(35,8)40(37)23-25-43(38,39)9)50-41(47)45-27-12-10-11-13-28-48-51(49-29-15-26-44)46(32(3)4)33(5)6/h18,31-34,36-40H,10-17,19-25,27-30H2,1-9H3,(H,45,47)/t34-,36+,37+,38-,39+,40+,42+,43-,51?/m1/s1

Synonyms: Cholest-5-en-3-ol (3β)-, 3-[[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl]carbamate]; Cholest-5-en-3-ol (3β)-, [6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl]carbamate; Cholesteryl-3-carboxamidohexyl-[2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Cholest-5-en-3-ol, 3-(6-(((2-cyanoethoxy)(diisopropylamino)phosphino)oxy)hexyl)carbemate; 5'-Cholesterol-CE-Phosphoramidite; Cholesteryl-3-carboxamidohexyl-[2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

ANA 2'-F MeC(Bz) amidite

2'-F N1-Methyl PseudoUridine amidite

2'-F C(Ac) OBn-amidite

2'-F A(Bz) OBn-amidite

2'-F G(iBu) OBn-amidite

2'-F U OBn-amidite

2'-F G(iBu) (TBSO)SATE-amidite

2'-F A(Bz) (TBSO)SATE-amidite

2'-F C(Bz) (TBSO)SATE-amidite

2'-F U (TBSO)SATE-amidite

2'-F U Obutyn-amidite

2'-F C(Ac) Obutyn-amidite

2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Uridine 3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Adenosine (N-PAC) 3'-O-BMEG phosphoramidite

5-O-DMTr-1-O-Ac-2-F-2-deoxyribofuranose-3-CE-Phosphoramidite

5-DMTr-2-F-1,2-dideoxyribose-3-CE-Phosphoramidite

3'-F-3'-dA(Bz)-2'-phosphoramidite

Cholesterol C6 amine amidite (BRP-01617)

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