What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) 3'-CE phosphoramidite

Description: 2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) 3'-CE phosphoramidite is a modified nucleoside phosphoramidite used in solid-phase synthesis of nucleic acids. This compound is useful for the synthesis of modified nucleic acids with enhanced properties for various applications.

CAT: BRP-01404

CAS: 1643773-48-1

Molecular Formula: C49H67N8O7PSi

Molecular Weight: 939.17

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InChIKey: BJXKSHKSYZVPKC-WMHLWPNPSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C=NC(N=CN(C)C)=NC32)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((dimethylamino)methylene)amino)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H67N8O7PSi/c1-34(2)57(35(3)4)65(61-29-17-28-50)63-43-42(31-60-49(36-18-15-14-16-19-36,37-20-24-39(58-10)25-21-37)38-22-26-40(59-11)27-23-38)62-46(44(43)64-66(12,13)48(5,6)7)56-33-52-41-30-51-47(54-45(41)56)53-32-55(8)9/h14-16,18-27,30,32-35,42-44,46H,17,29,31H2,1-13H3/t42-,43-,44-,46-,65?/m1/s1

Synonyms: Methanimidamide, N'-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]-N,N-dimethyl-; N'-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]-N,N-dimethylmethanimidamide; 2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) CED OP

Adenosine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Description: Adenosine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite is a chemical compound used in the synthesis of nucleic acids. It is a modified nucleoside phosphoramidite, which is used in solid-phase synthesis of oligonucleotides. This compound contains a modified adenosine base, a morpholino group, a cyanoethyl group, and a diisopropyl phosphoramidite group, all of which play important roles in the synthesis of high-quality oligonucleotides. The presence of the N-Benzoyl (Bz) group protects the amine functionality of the adenosine base during synthesis, while the morpholino group is used to enhance the hybridization properties of the oligonucleotide. The cyanoethyl and diisopropyl groups are used as leaving groups during the coupling reactions in the solid-phase synthesis. Overall, this compound is an important building block in the synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-01408

CAS: 2243974-80-1

Molecular Formula: C47H53N8O6P

Molecular Weight: 856.95

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InChIKey: ZRWXOZTUFQZCLQ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(N1CC(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N5C=NC=6C(=NC=NC65)NC(=O)C=7C=CC=CC7)N(C(C)C)C(C)C

IUPAC Name: N-(9-((2R,6S)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((2-cyanoethoxy)(diisopropylamino)phosphaneyl)morpholin-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C47H53N8O6P/c1-33(2)55(34(3)4)62(60-27-13-26-48)53-28-41(61-42(29-53)54-32-51-43-44(49-31-50-45(43)54)52-46(56)35-14-9-7-10-15-35)30-59-47(36-16-11-8-12-17-36,37-18-22-39(57-5)23-19-37)38-20-24-40(58-6)25-21-38/h7-12,14-25,31-34,41-42H,13,27-30H2,1-6H3,(H,49,50,52,56)

Cytidine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Description: Cytidine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite is a chemical compound used in the synthesis of nucleic acids, specifically in the process of solid-phase oligonucleotide synthesis. It is a modified cytidine residue with a benzoyl (Bz) protecting group on the amine group, a dimethoxytrityl (DMTr) protecting group on the hydroxyl group, and a morpholino group on the phosphate backbone. The cyanoethyl-N,N-diisopropyl diphosphoramidite is the phosphoramidite derivative used for coupling the cytidine residue to the growing oligonucleotide chain. This compound allows for efficient and selective incorporation of cytidine into the oligonucleotide sequence during synthesis.

CAT: BRP-01409

CAS: 2304678-30-4

Molecular Formula: C46H53N6O7P

Molecular Weight: 832.92

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InChIKey: SOMSQNICPOHJHU-UQSDLCBCSA-N

CanonicalSMILES: N#CCCOP(N1CC(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N5C=CC(=NC5=O)NC(=O)C=6C=CC=CC6)N(C(C)C)C(C)C

IUPAC Name: N-(1-((2R,6S)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((2-cyanoethoxy)(diisopropylamino)phosphaneyl)morpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C46H53N6O7P/c1-33(2)52(34(3)4)60(58-29-13-27-47)50-30-41(59-43(31-50)51-28-26-42(49-45(51)54)48-44(53)35-14-9-7-10-15-35)32-57-46(36-16-11-8-12-17-36,37-18-22-39(55-5)23-19-37)38-20-24-40(56-6)25-21-38/h7-12,14-26,28,33-34,41,43H,13,29-32H2,1-6H3,(H,48,49,53,54)/t41-,43+,60?/m0/s1

Synonyms: Phosphonamidous acid, P-[(2R,6S)-2-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-6-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-morpholinyl]-N,N-bis(1-methylethyl)-, 2-cyanoethyl ester

Guanosine-(N2-iBu)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Description: Guanosine-(N2-iBu)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite is a compound used in organic synthesis for the modification of nucleosides and nucleotides. It is a phosphoramidite derivative that can be used in the synthesis of modified RNA molecules for various research purposes. The compound contains a guanosine base modified at the N2 position with an isobutyl group, a methyleneoxy linker, a dimethoxytrityl (DMTr) protecting group, and a morpholino moiety. The cyanoethyl-N,N-diisopropyl diphosphoramidite group allows for efficient coupling reactions during RNA synthesis.

CAT: BRP-01410

CAS: 2243974-81-2

Molecular Formula: C44H55N8O7P

Molecular Weight: 838.93

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InChIKey: HQRPMELFURAQPY-VMZRNFFESA-N

CanonicalSMILES: N#CCCOP(N1CC(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N5C=NC=6C(=O)N=C(NC(=O)C(C)C)NC65)N(C(C)C)C(C)C

IUPAC Name: N-(9-((2R,6S)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((2-cyanoethoxy)(diisopropylamino)phosphaneyl)morpholin-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C44H55N8O7P/c1-29(2)41(53)48-43-47-40-39(42(54)49-43)46-28-51(40)38-26-50(60(58-24-12-23-45)52(30(3)4)31(5)6)25-37(59-38)27-57-44(32-13-10-9-11-14-32,33-15-19-35(55-7)20-16-33)34-17-21-36(56-8)22-18-34/h9-11,13-22,28-31,37-38H,12,24-27H2,1-8H3,(H2,47,48,49,53,54)/t37-,38+,60?/m0/s1

N3-Thiobenzoylethyl 2'-TBDMS Uridine 3'-CE phosphoramidite

Description: N3-Thiobenzoylethyl Uridine CED phosphoramidite is a compound used in oligonucleotide synthesis. It features uridine with a 2'-tert-butyldimethylsilyl (TBDMS) group, protecting the 2'-hydroxyl group, and a N3-thiobenzoylethyl group at the nitrogen atom of the uracil ring. Additionally, it includes a cyanoethyl (CE) group at the 3'-position and is attached to a phosphoramidite moiety for solid-phase synthesis. This compound facilitates the controlled synthesis of modified oligonucleotides, enabling precise chemical modifications and enhancing stability.

CAT: BRP-01413

Molecular Formula: C54H69N4O10PSSi

Molecular Weight: 1025.27

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InChIKey: QVVPMOVSGPVKRC-IHMJTFHYSA-N

IUPAC Name: S-(2-(3-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)ethyl) benzothioate

InChI: InChI=1S/C54H69N4O10PSSi/c1-38(2)58(39(3)4)69(65-35-18-32-55)67-48-46(37-64-54(41-21-16-13-17-22-41,42-23-27-44(62-8)28-24-42)43-25-29-45(63-9)30-26-43)66-50(49(48)68-71(10,11)53(5,6)7)57-33-31-47(59)56(52(57)61)34-36-70-51(60)40-19-14-12-15-20-40/h12-17,19-31,33,38-39,46,48-50H,18,34-37H2,1-11H3/t46-,48-,49-,50-,69?/m1/s1

Synonyms: N3-Thiobenzoylethyl Uridine CED phosphoramidite

N6-Benzyl 2'-TBDMS Adenosine CED phosphoramidite

Description: N6-Benzyl 2'-TBDMS Adenosine CED phosphoramidite is used in the solid-phase synthesis of RNA molecules. The N6-benzyl and 2'-TBDMS (tert-butyldimethylsilyl) protecting groups are commonly used to protect specific functional groups on the nucleoside, allowing for selective deprotection and further modification during the synthesis process. The CED (cyclohexyl-N,N-diisopropylaminoethyl) group is a phosphoramidite moiety used to facilitate the attachment of the nucleoside to the solid support during synthesis. This modified phosphoramidite is widely used in the field of nucleic acid chemistry for the synthesis of RNA molecules with specific modifications at the adenosine nucleoside position.

CAT: BRP-01414

Molecular Formula: C53H68N7O7PSi

Molecular Weight: 974.21

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InChIKey: GZBJCGYSXUSQQJ-MGEVAVFRSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-(benzylamino)-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H68N7O7PSi/c1-37(2)60(38(3)4)68(64-32-18-31-54)66-47-45(34-63-53(40-21-16-13-17-22-40,41-23-27-43(61-8)28-24-41)42-25-29-44(62-9)30-26-42)65-51(48(47)67-69(10,11)52(5,6)7)59-36-58-46-49(56-35-57-50(46)59)55-33-39-19-14-12-15-20-39/h12-17,19-30,35-38,45,47-48,51H,18,32-34H2,1-11H3,(H,55,56,57)/t45-,47-,48-,51-,68?/m1/s1

Synonyms: Adenosine, N-Benzyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-TBDMS A(Bn) 3'-CE phosphoramidite; N6-Benzyl Adenosine CED phosphoramidite

N6-Isopentenyl 2'-TBDMS Adenosine CED phosphoramidite

Description: N6-Isopentenyl 2'-TBDMS Adenosine CED phosphoramidite is a reagent used in solid-phase synthesis of oligonucleotides. It contains a modified adenosine nucleoside with a TBDMS (tert-butyldimethylsilyl) group at the 2'-position and a CED (2-cyanoethyl-N,N-diisopropyl) phosphoramidite group at the N6-position. This phosphoramidite derivative allows for efficient and selective coupling reactions during the synthesis of modified oligonucleotides.

CAT: BRP-01416

Molecular Formula: C51H70N7O7PSi

Molecular Weight: 952.20

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InChIKey: WCJAFYSVXPNXPT-VVPIBMPJSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-((3-methylbut-2-en-1-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H70N7O7PSi/c1-35(2)28-30-53-47-44-48(55-33-54-47)57(34-56-44)49-46(65-67(12,13)50(7,8)9)45(64-66(62-31-17-29-52)58(36(3)4)37(5)6)43(63-49)32-61-51(38-18-15-14-16-19-38,39-20-24-41(59-10)25-21-39)40-22-26-42(60-11)27-23-40/h14-16,18-28,33-34,36-37,43,45-46,49H,17,30-32H2,1-13H3,(H,53,54,55)/t43-,45-,46-,49-,66?/m1/s1

Synonyms: N6-Isopentenyl Adenosine CED phosphoramidite; N6-Isopentenyl 2'-TBDMS rA 3'-CE phosphoramidite

2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CEP

Description: 2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CEP is a specialized nucleotide used in the synthesis of modified oligonucleotides. It features protective groups for the 2'- and 5'-hydroxyls, the N2 amino group, and the 3'-hydroxyl, facilitating the stepwise addition of nucleotides during solid-phase synthesis. This compound is crucial for creating RNA and DNA molecules with enhanced stability and functionality, making it valuable in biochemical and medical research.

CAT: BRP-01423

CAS: 1792219-30-7

Molecular Formula: C57H70N7O12P

Molecular Weight: 1076.18

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InChIKey: NPTZAQHIJAFZFD-AGVGNCMWSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)COC4=CC=C(C=C4)C(C)C)NC32)C1OCOC(=O)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate

InChI: InChI=1S/C57H70N7O12P/c1-36(2)39-18-24-45(25-19-39)70-33-47(65)60-55-61-51-48(52(66)62-55)59-34-63(51)53-50(71-35-72-54(67)56(7,8)9)49(76-77(74-31-15-30-58)64(37(3)4)38(5)6)46(75-53)32-73-57(40-16-13-12-14-17-40,41-20-26-43(68-10)27-21-41)42-22-28-44(69-11)29-23-42/h12-14,16-29,34,36-38,46,49-50,53H,15,31-33,35H2,1-11H3,(H2,60,61,62,65,66)/t46-,49-,50-,53-,77?/m1/s1

Synonyms: 2'-OPivOM G(ipr-pac) amidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2,2-dimethyl-1-oxopropoxy)methyl]-N-[2-[4-(1-methylethyl)phenoxy]acetyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CE phosphoramidite

MMT-2'-tBDSilyl Adenosine (n-PAC) methyl phosphoramidite

Description: MMT-2'-tBDSilyl Adenosine (n-PAC) methyl phosphoramidite is a reagent used in oligonucleotide synthesis. It comprises adenosine with a monomethoxytrityl (MMT) protecting group at the 2'-position and a tert-butyldimethylsilyl (tBDSilyl) group at the 3'-position. Additionally, the amino group is protected by a phenoxyacetyl (PAC) group. This compound facilitates the controlled synthesis of modified oligonucleotides with enhanced stability and precise chemical modifications.

CAT: BRP-01424

Molecular Formula: C51H65N6O8PSi

Molecular Weight: 949.16

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InChIKey: SRIPSWWUYSURFE-ZPKZLDMBSA-N

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C=5C=CC=CC5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3O[Si](C)(C)C(C)(C)C)COC=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C51H65N6O8PSi/c1-35(2)57(36(3)4)66(60-9)64-45-42(31-62-51(37-21-15-12-16-22-37,38-23-17-13-18-24-38)39-27-29-40(59-8)30-28-39)63-49(46(45)65-67(10,11)50(5,6)7)56-34-54-44-47(52-33-53-48(44)56)55-43(58)32-61-41-25-19-14-20-26-41/h12-30,33-36,42,45-46,49H,31-32H2,1-11H3,(H,52,53,55,58)/t42-,45-,46-,49-,66?/m1/s1

Synonyms: 5'-O-MMTr-2'-OTBS A(Pac) OMe-amidite; 5'-O-MMTr-2'-O-TBDMS-A(Pac)-3'-Methoxy-phosphoramidite; Adenosine, 2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N-(phenoxyacetyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

MMT-2'-tBDSilyl Guanosine (n-PAC) methyl phosphoramidite

Description: MMT-2'-tBDSilyl Guanosine (n-PAC) methyl phosphoramidite is a reagent used in oligonucleotide synthesis. It consists of guanosine with a monomethoxytrityl (MMT) group protecting the 2'-position, a tert-butyldimethylsilyl (tBDSilyl) group protecting the 3'-position, and a phenoxyacetyl (PAC) group protecting the amino group. Additionally, it includes a methyl phosphoramidite moiety. This compound facilitates the controlled synthesis of modified oligonucleotides, providing increased stability and precise chemical modifications.

CAT: BRP-01425

Molecular Formula: C51H65N6O9PSi

Molecular Weight: 965.16

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InChIKey: KJVBHYXASYADQV-YPSZUEOQSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-(6-oxo-2-(2-phenoxyacetamido)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C51H65N6O9PSi/c1-34(2)57(35(3)4)67(61-9)65-44-41(31-63-51(36-21-15-12-16-22-36,37-23-17-13-18-24-37)38-27-29-39(60-8)30-28-38)64-48(45(44)66-68(10,11)50(5,6)7)56-33-52-43-46(56)54-49(55-47(43)59)53-42(58)32-62-40-25-19-14-20-26-40/h12-30,33-35,41,44-45,48H,31-32H2,1-11H3,(H2,53,54,55,58,59)/t41-,44-,45-,48-,67?/m1/s1

Synonyms: 5'-O-MMTr-2'-OTBS G(Pac) OMe-amidite; 5'-O-MMTr-2'-O-TBDMS-G(Pac)-3'-Methoxy-phosphoramidite

2'-tBDSilyl Adenosine (n-PAC) methyl phosphoramidite

Description: 5'-O-DMTr-2'-O-TBDMS-A(Pac)-3'-Methoxy-phosphoramidite is a reagent used in oligonucleotide synthesis. It includes adenosine with a dimethoxytrityl (DMTr) group at the 5'-position, a tert-butyldimethylsilyl (TBDMS) group at the 2'-position, a phenoxyacetyl (Pac) protecting group on the amino group, and a methoxy phosphoramidite at the 3'-position. This configuration enhances stability and allows precise incorporation of adenosine into synthetic oligonucleotides.

CAT: BRP-01426

Molecular Formula: C52H67N6O9PSi

Molecular Weight: 979.18

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InChIKey: PVCNWLDGLBVZQK-KJMRTUCVSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C52H67N6O9PSi/c1-35(2)58(36(3)4)68(62-10)66-46-43(31-64-52(37-19-15-13-16-20-37,38-23-27-40(60-8)28-24-38)39-25-29-41(61-9)30-26-39)65-50(47(46)67-69(11,12)51(5,6)7)57-34-55-45-48(53-33-54-49(45)57)56-44(59)32-63-42-21-17-14-18-22-42/h13-30,33-36,43,46-47,50H,31-32H2,1-12H3,(H,53,54,56,59)/t43-,46-,47-,50-,68?/m1/s1

Synonyms: 2'-OTBS A(Pac) OMe-amidite; 5'-O-DMTr-2'-O-TBDMS-A(Pac)-3'-Methoxy-phosphoramidite

2'-tBDSilyl Cytidine (n-PAC) methyl phosphoramidite

Description: 2'-tBDSilyl Cytidine (n-PAC) methyl phosphoramidite is a key reagent used in oligonucleotide synthesis. It consists of cytidine with a tert-butyldimethylsilyl (tBDSilyl) group protecting the 2'-position and a phenoxyacetyl (PAC) group guarding the amino group. Additionally, it contains a methyl phosphoramidite moiety. This compound facilitates the controlled synthesis of modified oligonucleotides, providing enhanced stability and enabling precise chemical modifications.

CAT: BRP-01427

Molecular Formula: C51H67N4O10PSi

Molecular Weight: 955.16

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InChIKey: AJLSWJSVOOCSFR-VUQXMIQESA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C51H67N4O10PSi/c1-35(2)55(36(3)4)66(60-10)64-46-43(33-62-51(37-19-15-13-16-20-37,38-23-27-40(58-8)28-24-38)39-25-29-41(59-9)30-26-39)63-48(47(46)65-67(11,12)50(5,6)7)54-32-31-44(53-49(54)57)52-45(56)34-61-42-21-17-14-18-22-42/h13-32,35-36,43,46-48H,33-34H2,1-12H3,(H,52,53,56,57)/t43-,46-,47-,48-,66?/m1/s1

Synonyms: 5'-O-DMTr-2'-OTBS C(Pac) OMe-amidite; 5'-O-DMTr-2'-O-TBDMS-C(Pac)-3'-Methoxy-phosphoramidite

2'-tBDSilyl Guanosine (n-PAC) methyl phosphoramidite

Description: 2'-tBDSilyl Guanosine (n-PAC) methyl phosphoramidite is a reagent commonly used in oligonucleotide synthesis. It consists of guanosine with a tert-butyldimethylsilyl (tBDSilyl) group protecting the 2'-position and a phenoxyacetyl (PAC) group protecting the amino group. Additionally, it features a methyl phosphoramidite moiety. This compound facilitates the controlled synthesis of modified oligonucleotides, providing increased stability and precise chemical modifications.

CAT: BRP-01428

Molecular Formula: C52H67N6O10PSi

Molecular Weight: 995.18

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InChIKey: CEBBQJQCBLOLKE-XIZLBUQOSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-oxo-2-(2-phenoxyacetamido)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C52H67N6O10PSi/c1-34(2)58(35(3)4)69(63-10)67-45-42(31-65-52(36-19-15-13-16-20-36,37-23-27-39(61-8)28-24-37)38-25-29-40(62-9)30-26-38)66-49(46(45)68-70(11,12)51(5,6)7)57-33-53-44-47(57)55-50(56-48(44)60)54-43(59)32-64-41-21-17-14-18-22-41/h13-30,33-35,42,45-46,49H,31-32H2,1-12H3,(H2,54,55,56,59,60)/t42-,45-,46-,49-,69?/m1/s1

Synonyms: 5'-O-DMTr-2'-OTBS G(Pac) OMe-amidite; 5'-O-DMTr-2'-O-TBDMS-G(Pac)-3'-Methoxy-phosphoramidite

2'-tBDSilyl Cytidine (n-bz) methyl phosphoramidite

Description: 2'-tBDSilyl Cytidine (n-bz) methyl phosphoramidite is a crucial component in the synthesis of modified oligonucleotides. This compound consists of cytidine with a tert-butyldimethylsilyl (tBDSilyl) group protecting the 2'-position and a benzoyl (n-bz) group guarding the amino group. Additionally, it includes a methyl phosphoramidite moiety. This reagent enables controlled oligonucleotide synthesis, allowing for precise chemical modifications and enhancing the stability of the resulting oligonucleotide strands.

CAT: BRP-01429

CAS: 118684-40-5

Molecular Formula: C50H65N4O9PSi

Molecular Weight: 925.15

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InChIKey: AJJZVDGKUIEJGA-LORUJQNASA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2O[Si](C)(C)C(C)(C)C)NC(=O)C=6C=CC=CC6

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C50H65N4O9PSi/c1-34(2)54(35(3)4)64(59-10)62-44-42(33-60-50(37-21-17-14-18-22-37,38-23-27-40(57-8)28-24-38)39-25-29-41(58-9)30-26-39)61-47(45(44)63-65(11,12)49(5,6)7)53-32-31-43(52-48(53)56)51-46(55)36-19-15-13-16-20-36/h13-32,34-35,42,44-45,47H,33H2,1-12H3,(H,51,52,55,56)/t42-,44-,45-,47-,64?/m1/s1

Synonyms: 5'-O-DMTr-2'-OTBS C(Bz) OMe-amidite; 5'-O-DMTr-2'-O-TBDMS-C(Bz)-3'-Methoxy-phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

MMT-2'-tBDSilyl Adenosine (n-bz) methyl phosphoramidite

Description: MMT-2'-tBDSilyl Adenosine (n-bz) methyl phosphoramidite is a reagent utilized in oligonucleotide synthesis. It consists of adenosine with a monomethoxytrityl (MMT) protecting group at the 2'-position and a tert-butyldimethylsilyl (tBDSilyl) group at the 3'-position. The amino group is safeguarded by a benzoyl (bz) group. This compound is employed to synthesize modified oligonucleotides with increased stability and precise chemical modifications.

CAT: BRP-01430

CAS: 101904-21-6

Molecular Formula: C50H63N6O7PSi

Molecular Weight: 919.15

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InChIKey: NUQPPYCKFPVDHB-HHRUMCNBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OC)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[[di(propan-2-yl)amino]-methoxyphosphanyl]oxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C50H63N6O7PSi/c1-34(2)56(35(3)4)64(59-9)62-43-41(31-60-50(37-23-17-13-18-24-37,38-25-19-14-20-26-38)39-27-29-40(58-8)30-28-39)61-48(44(43)63-65(10,11)49(5,6)7)55-33-53-42-45(51-32-52-46(42)55)54-47(57)36-21-15-12-16-22-36/h12-30,32-35,41,43-44,48H,31H2,1-11H3,(H,51,52,54,57)/t41-,43-,44-,48-,64?/m1/s1

Synonyms: Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-MMTr-2'-OTBS A(Bz) OMe-amidite; 5'-O-MMTr-2'-O-TBDMS-A(Bz)-3'-Methoxy-phosphoramidite

MMT-2'-tBDSilyl Guanosine (n-ibu) methyl phosphoramidite

Description: MMT-2'-tBDSilyl Guanosine (n-ibu) methyl phosphoramidite is a reagent commonly used in oligonucleotide synthesis. It consists of guanosine with a monomethoxytrityl (MMT) group protecting the 2'-position, a tert-butyldimethylsilyl (tBDSilyl) group protecting the 3'-position, and an isobutyryl (n-ibu) group protecting the amino group. This compound enables the controlled synthesis of modified oligonucleotides, providing increased stability and precise chemical modifications.

CAT: BRP-01431

Molecular Formula: C47H65N6O8PSi

Molecular Weight: 901.13

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InChIKey: WRCLQRTWWDMGKQ-DMWBDYODSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C47H65N6O8PSi/c1-30(2)42(54)50-45-49-41-38(43(55)51-45)48-29-52(41)44-40(61-63(12,13)46(7,8)9)39(60-62(57-11)53(31(3)4)32(5)6)37(59-44)28-58-47(33-20-16-14-17-21-33,34-22-18-15-19-23-34)35-24-26-36(56-10)27-25-35/h14-27,29-32,37,39-40,44H,28H2,1-13H3,(H2,49,50,51,54,55)/t37-,39-,40-,44-,62?/m1/s1

Synonyms: 5'-O-MMTr-2'-OTBS G(iBu) OMe-amidite; 5'-O-MMTr-2'-O-TBDMS-G(iBu)-3'-Methoxy-phosphoramidite

Psoralen 18-Atom Spacer CED phosphoramidite

Description: The Psoralen 18-Atom Spacer CED phosphoramidite is a specialized compound used in nucleic acid synthesis. It combines the photoreactive properties of psoralen with an 18-atom spacer and a CED phosphoramidite group. This enables controlled modification of nucleic acids, allowing for the introduction of psoralen moieties at specific positions within DNA or RNA strands. These modifications can then be crosslinked under ultraviolet (UV) light, making this compound valuable in various molecular biology applications, including DNA-protein interaction studies and nucleic acid structure mapping.

CAT: BRP-01437

Molecular Formula: C36H55N2O11P

Molecular Weight: 722.80

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InChIKey: VDDDZCZDLKUGAG-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCOCCOCCOCCOCCOCCOCC1=C(OC2=C1C=C(C(C)=C3)C(OC3=O)=C2C)C)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (1-(2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)-2,5,8,11,14,17-hexaoxanonadecan-19-yl) diisopropylphosphoramidite

InChI: InChI=1S/C36H55N2O11P/c1-26(2)38(27(3)4)50(46-10-8-9-37)47-22-21-44-18-17-42-14-13-40-11-12-41-15-16-43-19-20-45-25-33-30(7)48-36-29(6)35-31(24-32(33)36)28(5)23-34(39)49-35/h23-24,26-27H,8,10-22,25H2,1-7H3

Psoralen phosphoramidite

Description: Psoralen phosphoramidite is a compound used in nucleic acid synthesis, particularly in molecular biology and genetic research. It incorporates a psoralen derivative, a naturally occurring compound known for its ability to crosslink with nucleic acids upon exposure to ultraviolet (UV) light. This phosphoramidite form allows for the controlled addition of psoralen to oligonucleotide chains during solid-phase synthesis, enabling precise positioning within DNA or RNA strands. Psoralen phosphoramidite is valuable for applications involving the study of DNA-protein interactions, nucleic acid structure, and as a tool in various molecular biology techniques.

CAT: BRP-01438

Molecular Formula: C48H55N2O9P

Molecular Weight: 834.93

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InChIKey: BJYRTACQFJUEHM-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(COC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)COCC4=C(OC5=C4C=C(C(C)=C6)C(OC6=O)=C5C)C)N(C(C)C)C(C)C

IUPAC Name: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H55N2O9P/c1-31(2)50(32(3)4)60(56-25-13-24-49)59-41(28-54-30-44-35(7)57-47-34(6)46-42(27-43(44)47)33(5)26-45(51)58-46)29-55-48(36-14-11-10-12-15-36,37-16-20-39(52-8)21-17-37)38-18-22-40(53-9)23-19-38/h10-12,14-23,26-27,31-32,41H,13,25,28-30H2,1-9H3

Psoralen C-4 CED phosphoramidite

Description: Psoralen C-4 CED phosphoramidite is a specialized compound utilized in nucleic acid synthesis, particularly in molecular biology and genetic research. It likely incorporates a psoralen derivative with modification at the C-4 position, enabling controlled interactions with nucleic acids. The CED phosphoramidite moiety facilitates its incorporation into oligonucleotide chains during solid-phase synthesis, allowing for precise positioning within DNA or RNA strands. This compound is valuable for applications involving psoralen-mediated crosslinking, which is useful for studying DNA-protein interactions and nucleic acid structure.

CAT: BRP-01439

Molecular Formula: C28H39N2O6P

Molecular Weight: 530.59

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InChIKey: KOBCWUDIRGLRAB-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCOCC1=C(OC2=C1C=C(C(C)=C3)C(OC3=O)=C2C)C)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (4-((2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)methoxy)butyl) diisopropylphosphoramidite

InChI: InChI=1S/C28H39N2O6P/c1-18(2)30(19(3)4)37(34-14-10-11-29)33-13-9-8-12-32-17-25-22(7)35-28-21(6)27-23(16-24(25)28)20(5)15-26(31)36-27/h15-16,18-19H,8-10,12-14,17H2,1-7H3

Synonyms: Psoralen-C4 CEP; Psoralen C4 Phosphoramidite

2'-O-Methyl-3'-DMT Cytidine (n-bz) 5'-CED phosphoramidite

Description: 2'-O-Methyl-3'-DMT 5-Methyl-Cytidine (N-Bz) 5'-CED Phosphoramidite is a specialized nucleotide compound essential in oligonucleotide synthesis. Featuring a 2'-O-methyl modification and a 3'-DMT protecting group for stability, it also incorporates a 5-methyl-cytidine base with a benzoyl (Bz) modification at the N4 position. Its 5'-CED phosphoramidite functionality enables controlled addition to oligonucleotide chains, offering versatility and precision in molecular biology research and nucleic acid design.

CAT: BRP-01450

CAS: 2101622-72-2

Molecular Formula: C47H54N5O9P

Molecular Weight: 863.93

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InChIKey: MCJDWFDEBMUCDZ-VKBHKTMGSA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C(OC)C1OC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: ((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-methoxytetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H54N5O9P/c1-32(2)52(33(3)4)62(58-30-14-28-48)59-31-40-42(43(57-7)45(60-40)51-29-27-41(50-46(51)54)49-44(53)34-15-10-8-11-16-34)61-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3,(H,49,50,53,54)/t40-,42-,43-,45-,62?/m1/s1

Synonyms: Cytidine, N-benzoyl-2'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-O-Me-3'-DMT C(Bz) 5'-CE phosphoramidite; 3'-DMT-2'-OMe-C(Bz)-CE Reverse