What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

2',3'-Diacetyl Guanosine (n-ibu) CED phosphoramidite

Description: 2',3'-Diacetyl Guanosine (n-ibu) CED phosphoramidite is a chemically modified guanosine nucleotide used in oligonucleotide synthesis. Featuring acetyl groups at the 2' and 3' positions and a CED (cyanoethyl diisopropylamino) phosphoramidite group, it facilitates the creation of stable, high-fidelity DNA and RNA sequences for advanced genetic research and biotechnological applications.

CAT: BRP-01255

CAS: 1350450-67-7

Molecular Formula: C27H40N7O9P

Molecular Weight: 637.63

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InChIKey: IGPBVQCAEJGBML-KIDUIKHZSA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C(OC(=O)C)C1OC(=O)C)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

InChI: InChI=1S/C27H40N7O9P/c1-14(2)24(37)31-27-30-23-20(25(38)32-27)29-13-33(23)26-22(42-18(8)36)21(41-17(7)35)19(43-26)12-40-44(39-11-9-10-28)34(15(3)4)16(5)6/h13-16,19,21-22,26H,9,11-12H2,1-8H3,(H2,30,31,32,37,38)/t19-,21-,22-,26-,44?/m1/s1

Synonyms: Guanosine, N-(2-methyl-1-oxopropyl)-, 2',3'-diacetate 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

2',3'-Diacetyl Uridine CED phosphoramidite

Description: 2',3'-Diacetyl Uridine CED phosphoramidite is a modified uridine nucleotide used in the synthesis of RNA and DNA oligonucleotides. It has acetyl groups at the 2' and 3' positions and a CED (cyanoethyl diisopropylamino) phosphoramidite group, enabling the production of stable and high-fidelity nucleic acid sequences for genetic research and biotechnological applications.

CAT: BRP-01256

CAS: 208655-84-9

Molecular Formula: C22H33N4O9P

Molecular Weight: 528.49

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InChIKey: QUNYGIBAHMVXKK-UZKKNRNZSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1C(C(C(O1)N2C=CC(=O)NC2=O)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-4-acetyloxy-2-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl] acetate

InChI: InChI=1S/C22H33N4O9P/c1-13(2)26(14(3)4)36(31-11-7-9-23)32-12-17-19(33-15(5)27)20(34-16(6)28)21(35-17)25-10-8-18(29)24-22(25)30/h8,10,13-14,17,19-21H,7,11-12H2,1-6H3,(H,24,29,30)/t17-,19-,20-,21-,36?/m1/s1

Synonyms: Uridine, 2',3'-diacetate 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 2',3'-diacetate 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

2'-O-butyne Uridine CED phosphoramidite

Description: 2'-O-butyne Uridine CED phosphoramidite is a chemical compound used in oligonucleotide synthesis. It is a derivative of uridine, where the 2' position of the ribose sugar is modified with a butyne group (-C≡C-) and is functionalized with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. This modification allows for the selective incorporation of the modified uridine into the growing nucleotide chain during solid-phase synthesis of oligonucleotides. The presence of the butyne group enables further chemical reactions for the conjugation of various functional groups or molecules. This compound plays a crucial role in the design and synthesis of specialized oligonucleotides for applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01258

CAS: 2305570-48-1

Molecular Formula: C43H51N4O9P

Molecular Weight: 798.86

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InChIKey: IZIBOIGAGRJZFP-QBLJBMGASA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=O)C1OCC#CC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(but-2-yn-1-yloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H51N4O9P/c1-8-9-27-52-40-39(56-57(54-28-13-25-44)47(30(2)3)31(4)5)37(55-41(40)46-26-24-38(48)45-42(46)49)29-53-43(32-14-11-10-12-15-32,33-16-20-35(50-6)21-17-33)34-18-22-36(51-7)23-19-34/h10-12,14-24,26,30-31,37,39-41H,13,27-29H2,1-7H3,(H,45,48,49)/t37-,39-,40-,41-,57?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-butyne-U-3'-CE-Phosphoramidite

2'-O-butyne Adenosine (n-bz) CED phosphoramidite

Description: 2'-O-butyne Adenosine (n-bz) CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It consists of an adenosine nucleoside with a modification at the 2' position of the ribose sugar, where a butyne (-C≡C-) group is attached. Additionally, it features a benzoyl (n-bz) group to protect the amino group at the N6 position of adenine and a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. This modification enables the selective incorporation of the modified adenosine into the growing nucleotide chain during solid-phase synthesis of oligonucleotides. The presence of the butyne group allows for further functionalization or conjugation, making it useful for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01259

Molecular Formula: C51H56N7O8P

Molecular Weight: 926.01

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InChIKey: FNMMYMFLDRVDOX-LTMMGAFGSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(but-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H56N7O8P/c1-8-9-30-62-46-45(66-67(64-31-16-29-52)58(35(2)3)36(4)5)43(65-50(46)57-34-55-44-47(53-33-54-48(44)57)56-49(59)37-17-12-10-13-18-37)32-63-51(38-19-14-11-15-20-38,39-21-25-41(60-6)26-22-39)40-23-27-42(61-7)28-24-40/h10-15,17-28,33-36,43,45-46,50H,16,30-32H2,1-7H3,(H,53,54,56,59)/t43-,45-,46-,50-,67?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-butyne-A(Bz)-3'-CE-Phosphoramidite

2'-O-butyne Guanosine (n-ibu) CED phosphoramidite

Description: 2'-O-butyne Guanosine (n-ibu) CED phosphoramidite is a specialized compound utilized in oligonucleotide synthesis. It consists of a guanosine nucleoside with a modification at the 2' position of the ribose sugar, where a butyne (-C≡C-) group is attached. Additionally, it features an isobutyryl (n-ibu) group to protect the amino group at the N2 position of guanine and a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. This modification allows for the selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis of oligonucleotides. The presence of the butyne group enables further functionalization or conjugation, making it valuable for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01260

Molecular Formula: C48H58N7O9P

Molecular Weight: 907.99

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InChIKey: ABJZHECXWHOPKB-VKFKYRIUSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(but-2-yn-1-yloxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H58N7O9P/c1-10-11-27-60-42-41(64-65(62-28-15-26-49)55(32(4)5)33(6)7)39(63-46(42)54-30-50-40-43(54)51-47(53-45(40)57)52-44(56)31(2)3)29-61-48(34-16-13-12-14-17-34,35-18-22-37(58-8)23-19-35)36-20-24-38(59-9)25-21-36/h12-14,16-25,30-33,39,41-42,46H,15,27-29H2,1-9H3,(H2,51,52,53,56,57)/t39-,41-,42-,46-,65?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-butyne-G(iBu)-3'-CE-Phosphoramidite

2'-O-butyne Cytidine (n-bz) CED phosphoramidite

Description: 2'-O-butyne Cytidine (n-bz) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-butyne group and protected with a benzoyl (n-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified cytidine into the growing nucleotide chain during solid-phase synthesis. The presence of the butyne group enables further chemical reactions for the conjugation of various functional groups or molecules. This compound plays a crucial role in the design and synthesis of specialized oligonucleotides for applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01265

Molecular Formula: C50H56N5O9P

Molecular Weight: 901.98

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InChIKey: ZCJRISCCQSIUEK-BZESDKEVSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(but-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H56N5O9P/c1-8-9-32-60-46-45(64-65(62-33-16-30-51)55(35(2)3)36(4)5)43(63-48(46)54-31-29-44(53-49(54)57)52-47(56)37-17-12-10-13-18-37)34-61-50(38-19-14-11-15-20-38,39-21-25-41(58-6)26-22-39)40-23-27-42(59-7)28-24-40/h10-15,17-29,31,35-36,43,45-46,48H,16,32-34H2,1-7H3,(H,52,53,56,57)/t43-,45-,46-,48-,65?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-butyne-C(Bz)-3'-CE-Phosphoramidite

2'-O-Methyl Guanosine (n-PAC) CED phosphoramidite

Description: 2'-O-Methyl Guanosine (n-PAC) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-O-Methyl group and protected with a PAC (phenoxyacetyl) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. The presence of the 2'-O-Methyl group provides stability and can influence the properties of the resulting oligonucleotide. This compound is essential in the design and synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01267

CAS: 138906-79-3

Molecular Formula: C49H56N7O10P

Molecular Weight: 933.96

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InChIKey: FBLBODSDYPHQTB-KPWHVHSNSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)COC=4C=CC=CC4)NC32)C1OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-oxo-2-(2-phenoxyacetamido)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H56N7O10P/c1-32(2)56(33(3)4)67(64-28-14-27-50)66-43-40(29-63-49(34-15-10-8-11-16-34,35-19-23-37(59-5)24-20-35)36-21-25-38(60-6)26-22-36)65-47(44(43)61-7)55-31-51-42-45(55)53-48(54-46(42)58)52-41(57)30-62-39-17-12-9-13-18-39/h8-13,15-26,31-33,40,43-44,47H,14,28-30H2,1-7H3,(H2,52,53,54,57,58)/t40-,43-,44-,47-,67?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-G(Pac)-3'-CE-Phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

MMT-2'-O-Methyl Adenosine (n-bz) CED phosphoramidite

Description: MMT-2'-O-Methyl Adenosine (n-bz) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a benzoyl (n-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. The MMT (Monomethoxytrityl) group is typically used for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative allows for efficient and selective incorporation of the modified adenosine into the growing nucleotide chain during solid-phase synthesis. This compound is crucial in the design and synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01270

CAS: 2645354-88-5

Molecular Formula: C47H52N7O7P

Molecular Weight: 857.93

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InChIKey: GBMKDKSAHVWHSY-JIUDHRTHSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OC)COC(C=5C=CC=CC5)(C=6C=CC=CC6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-4-methoxy-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-28-16-27-48)61-41-39(29-58-47(35-19-12-8-13-20-35,36-21-14-9-15-22-36)37-23-25-38(56-5)26-24-37)60-46(42(41)57-6)53-31-51-40-43(49-30-50-44(40)53)52-45(55)34-17-10-7-11-18-34/h7-15,17-26,30-33,39,41-42,46H,16,28-29H2,1-6H3,(H,49,50,52,55)/t39-,41-,42-,46-,62?/m1/s1

Synonyms: 5'-O-MMTr-2'-O-Methyl-A(Bz)-3'-CE-Phosphoramidite

MMT-2'-O-Methyl Guanosine (n-ibu) CED phosphoramidite

Description: MMT-2'-O-Methyl Guanosine (n-ibu) CED phosphoramidite is a specialized reagent employed in oligonucleotide synthesis. It features a guanosine nucleoside with a 2'-O-Methyl modification, protected by an isobutyryl (n-ibu) group, and coupled with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. The MMT (Monomethoxytrityl) group temporarily shields hydroxyl groups in nucleosides during synthesis. This phosphoramidite enables precise incorporation of the modified guanosine into nucleotide chains during solid-phase synthesis, vital for tailored oligonucleotide design in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01271

CAS: 110782-32-6

Molecular Formula: C44H54N7O8P

Molecular Weight: 839.92

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InChIKey: FJAOBUANVXIWLD-FRQJXJFPSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OC)COC(C=4C=CC=CC4)(C=5C=CC=CC5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxy-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C44H54N7O8P/c1-28(2)40(52)48-43-47-39-36(41(53)49-43)46-27-50(39)42-38(55-8)37(59-60(57-25-15-24-45)51(29(3)4)30(5)6)35(58-42)26-56-44(31-16-11-9-12-17-31,32-18-13-10-14-19-32)33-20-22-34(54-7)23-21-33/h9-14,16-23,27-30,35,37-38,42H,15,25-26H2,1-8H3,(H2,47,48,49,52,53)/t35-,37-,38-,42-,60?/m1/s1

Synonyms: Guanosine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-MMTr-2'-O-Methyl-G(iBu)-3'-CE-Phosphoramidite

2'-O-Methyl Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Cytidine (N-PAC) 3'-O-BMEG phosphoramidite is utilized in oligonucleotide synthesis. It involves a cytidine nucleoside that has been modified with a 2'-O-Methyl group, protected with a PAC group (phenoxyacetyl), and coupled with a 3'-O-BMEG (3'-O-benzyl-2'-O-methyl-2'-O-(2-cyanoethyl) guanosine) phosphoramidite. It facilitates the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, critical for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01274

Molecular Formula: C53H67N4O12PS

Molecular Weight: 1015.16

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InChIKey: BDDJICCPICJTLQ-KLVGKUQJSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C53H67N4O12PS/c1-36(2)51(59)71-33-32-64-30-31-67-70(57(37(3)4)38(5)6)69-48-45(68-50(49(48)63-9)56-29-28-46(55-52(56)60)54-47(58)35-65-44-18-14-11-15-19-44)34-66-53(39-16-12-10-13-17-39,40-20-24-42(61-7)25-21-40)41-22-26-43(62-8)27-23-41/h10-29,36-38,45,48-50H,30-35H2,1-9H3,(H,54,55,58,60)/t45-,48-,49-,50-,70?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-C(Pac)-3'-O-BMEG phosphoramidite

2'-O-Methyl Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite is used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-O-Methyl group, protected with an isopropylphenoxyacetyl (iPr-Pac) group, and coupled with a 3'-O-BMEG phosphoramidite. It enables controlled and efficient incorporation of modified guanosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01275

Molecular Formula: C57H73N6O12PS

Molecular Weight: 1097.26

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InChIKey: CXMDDZTWWYKURH-PZUNXSRFSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C57H73N6O12PS/c1-36(2)40-17-23-46(24-18-40)71-34-48(64)59-56-60-52-49(53(65)61-56)58-35-62(52)54-51(69-11)50(75-76(63(38(5)6)39(7)8)73-30-29-70-31-32-77-55(66)37(3)4)47(74-54)33-72-57(41-15-13-12-14-16-41,42-19-25-44(67-9)26-20-42)43-21-27-45(68-10)28-22-43/h12-28,35-39,47,50-51,54H,29-34H2,1-11H3,(H2,59,60,61,64,65)/t47-,50-,51-,54-,76?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-G(iPr-Pac)-3'-O-BMEG phosphoramidite

2'-O-Methyl Uridine 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Uridine 3'-O-BMEG phosphoramidite is employed in oligonucleotide synthesis. It features a uridine nucleoside modified with a 2'-O-Methyl group and coupled with a 3'-O-BMEG phosphoramidite. It enables the precise incorporation of modified uridine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01276

CAS: 1219597-71-3

Molecular Formula: C45H60N3O11PS

Molecular Weight: 882.01

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InChIKey: REAOWVIOVQIPDP-FSEQMNGPSA-N

CanonicalSMILES: CC(C)C(=O)SCCOCCOP(N(C(C)C)C(C)C)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: S-[2-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethyl] 2-methylpropanethioate

InChI: InChI=1S/C45H60N3O11PS/c1-30(2)43(50)61-28-27-55-25-26-57-60(48(31(3)4)32(5)6)59-40-38(58-42(41(40)54-9)47-24-23-39(49)46-44(47)51)29-56-45(33-13-11-10-12-14-33,34-15-19-36(52-7)20-16-34)35-17-21-37(53-8)22-18-35/h10-24,30-32,38,40-42H,25-29H2,1-9H3,(H,46,49,51)/t38-,40-,41-,42-,60?/m1/s1

Synonyms: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate; 5'-O-DMTr-2'-O-Methyl-U-3'-O-BMEG phosphoramidite

2'-O-Methyl Adenosine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Adenosine (N-PAC) 3'-O-BMEG phosphoramidite is utilized in oligonucleotide synthesis. It comprises an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a PAC group (phenoxyacetyl), coupled with a 3'-O-BMEG (3'-O-benzyl-2'-O-methyl-2'-O-(2-cyanoethyl) guanosine) phosphoramidite. It facilitates precise incorporation of modified adenosine into nucleotide chains during solid-phase synthesis, critical for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01277

CAS: 1219597-69-9

Molecular Formula: C54H67N6O11PS

Molecular Weight: 1039.18

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InChIKey: DZVZJNHAUNNRRG-JHMFWHMXSA-N

CanonicalSMILES: CC(C)C(=O)SCCOCCOP(N(C(C)C)C(C)C)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: S-[2-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[6-[(2-phenoxyacetyl)amino]purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethyl] 2-methylpropanethioate

InChI: InChI=1S/C54H67N6O11PS/c1-36(2)53(62)73-31-30-66-28-29-69-72(60(37(3)4)38(5)6)71-48-45(32-68-54(39-16-12-10-13-17-39,40-20-24-42(63-7)25-21-40)41-22-26-43(64-8)27-23-41)70-52(49(48)65-9)59-35-57-47-50(55-34-56-51(47)59)58-46(61)33-67-44-18-14-11-15-19-44/h10-27,34-38,45,48-49,52H,28-33H2,1-9H3,(H,55,56,58,61)/t45-,48-,49-,52-,72?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-A(Pac)-3'-O-BMEG phosphoramidite; S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-phenoxyacetyl)-, 3'-[2-[2-[(2-methyl-1-oxopropyl)thio]ethoxy]ethyl N,N-bis(1-methylethyl)phosphoramidite]

2'-O-Methyl Adenosine (n-bz) ethyl phosphoramidite

Description: 2'-O-Methyl Adenosine (n-bz) ethyl phosphoramidite is used in oligonucleotide synthesis. It involves an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a benzoyl (n-bz) group, coupled with an ethyl phosphoramidite. It enables controlled and efficient incorporation of modified adenosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01278

CAS: 179478-97-8

Molecular Formula: C47H55N6O8P

Molecular Weight: 862.95

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InChIKey: UGNHWRCMCLTGDV-JIUDHRTHSA-N

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC)N(C(C)C)C(C)C)C3OC)C=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C47H55N6O8P/c1-9-59-62(53(31(2)3)32(4)5)61-41-39(60-46(42(41)57-8)52-30-50-40-43(48-29-49-44(40)52)51-45(54)33-16-12-10-13-17-33)28-58-47(34-18-14-11-15-19-34,35-20-24-37(55-6)25-21-35)36-22-26-38(56-7)27-23-36/h10-27,29-32,39,41-42,46H,9,28H2,1-8H3,(H,48,49,51,54)/t39-,41-,42-,46-,62?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-A(Bz) ethyl phosphoramidite

2'-O-Methyl Cytidine (n-bz) ethyl phosphoramidite

Description: 2'-O-Methyl Cytidine (n-bz) ethyl phosphoramidite is employed in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-Methyl group, protected with a benzoyl (n-bz) group, and coupled with an ethyl phosphoramidite. It facilitates the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01279

CAS: 179478-98-9

Molecular Formula: C46H55N4O9P

Molecular Weight: 838.93

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InChIKey: LZRBPQBDBLCFDX-ZRLRMURESA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCC)N(C(C)C)C(C)C)C2OC)NC(=O)C=6C=CC=CC6

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C46H55N4O9P/c1-9-57-60(50(31(2)3)32(4)5)59-41-39(58-44(42(41)55-8)49-29-28-40(48-45(49)52)47-43(51)33-16-12-10-13-17-33)30-56-46(34-18-14-11-15-19-34,35-20-24-37(53-6)25-21-35)36-22-26-38(54-7)27-23-36/h10-29,31-32,39,41-42,44H,9,30H2,1-8H3,(H,47,48,51,52)/t39-,41-,42-,44-,60?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-C(Bz) ethyl phosphoramidite

2'-O-Methyl Guanosine (n-ibu) ethyl phosphoramidite

Description: 2'-O-Methyl Guanosine (n-ibu) ethyl phosphoramidite is utilized in oligonucleotide synthesis. It features a guanosine nucleoside modified with a 2'-O-Methyl group, protected with an isobutyryl (n-ibu) group, and coupled with an ethyl phosphoramidite. It enables controlled and efficient incorporation of modified guanosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01280

CAS: 179478-99-0

Molecular Formula: C44H57N6O9P

Molecular Weight: 844.92

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InChIKey: WSJCHORSJDZQEN-FRQJXJFPSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC)N(C(C)C)C(C)C)C3OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C44H57N6O9P/c1-11-57-60(50(28(4)5)29(6)7)59-37-35(58-42(38(37)55-10)49-26-45-36-39(49)46-43(48-41(36)52)47-40(51)27(2)3)25-56-44(30-15-13-12-14-16-30,31-17-21-33(53-8)22-18-31)32-19-23-34(54-9)24-20-32/h12-24,26-29,35,37-38,42H,11,25H2,1-10H3,(H2,46,47,48,51,52)/t35-,37-,38-,42-,60?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-G(iBu) ethyl phosphoramidite

2'-O-Methyl Uridine ethyl phosphoramidite

Description: 2'-O-Methyl Uridine ethyl phosphoramidite is used in oligonucleotide synthesis. It comprises a uridine nucleoside modified with a 2'-O-Methyl group and coupled with an ethyl phosphoramidite. It facilitates the precise incorporation of modified uridine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01281

CAS: 179479-00-6

Molecular Formula: C39H50N3O9P

Molecular Weight: 735.81

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InChIKey: COIUWZYORZFHID-SGXIJWRWSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCC)N(C(C)C)C(C)C)C2OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C39H50N3O9P/c1-9-49-52(42(26(2)3)27(4)5)51-35-33(50-37(36(35)47-8)41-24-23-34(43)40-38(41)44)25-48-39(28-13-11-10-12-14-28,29-15-19-31(45-6)20-16-29)30-17-21-32(46-7)22-18-30/h10-24,26-27,33,35-37H,9,25H2,1-8H3,(H,40,43,44)/t33-,35-,36-,37-,52?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-U ethyl phosphoramidite

2'-O-Methyl Cytidine (n-ibu) p-methyl phosphonamidite

Description: 2'-O-Methyl Cytidine (n-ibu) p-methyl phosphonamidite is employed in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-Methyl group, protected with an isobutyryl (n-ibu) group, and coupled with a p-methyl phosphonamidite. It enables the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01282

CAS: 168752-56-5

Molecular Formula: C42H55N4O8P

Molecular Weight: 774.88

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InChIKey: ZWZQOFGHEWDFET-CMUCOHJHSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(C)N(C(C)C)C(C)C)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-methylphosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]-2-methylpropanamide

InChI: InChI=1S/C42H55N4O8P/c1-27(2)39(47)43-36-24-25-45(41(48)44-36)40-38(51-9)37(54-55(10)46(28(3)4)29(5)6)35(53-40)26-52-42(30-14-12-11-13-15-30,31-16-20-33(49-7)21-17-31)32-18-22-34(50-8)23-19-32/h11-25,27-29,35,37-38,40H,26H2,1-10H3,(H,43,44,47,48)/t35-,37-,38-,40-,55?/m1/s1

Synonyms: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidate]; 5'-O-DMTr-2'-O-Methyl-C(iBu) p-methyl phosphonamidite

2'-O-propargyl Cytidine (n-bz) CED phosphoramidite

Description: 2'-O-Propargyl Cytidine (N-bz) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a propargyl group at the 2' position and protected with a benzoyl (N-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified cytidine into the growing nucleotide chain during solid-phase synthesis. The presence of specific functional groups facilitates controlled chemical reactions, ensuring accurate and efficient synthesis of oligonucleotides for various applications in molecular biology, genetics, and diagnostics.

CAT: BRP-01287

CAS: 171486-60-5

Molecular Formula: C49H54N5O9P

Molecular Weight: 887.96

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InChIKey: AKMZLNQAQZVELP-LORUJQNASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC#C)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C49H54N5O9P/c1-8-31-59-45-44(63-64(61-32-15-29-50)54(34(2)3)35(4)5)42(62-47(45)53-30-28-43(52-48(53)56)51-46(55)36-16-11-9-12-17-36)33-60-49(37-18-13-10-14-19-37,38-20-24-40(57-6)25-21-38)39-22-26-41(58-7)27-23-39/h1,9-14,16-28,30,34-35,42,44-45,47H,15,31-33H2,2-7H3,(H,51,52,55,56)/t42-,44-,45-,47-,64?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propynyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-O-Propargyl C(Bz)-3'-phosphoramidite; DMTr-2'-O-propargyl-rC(Bz)-3'-CE-Phosphoramidite; N4-Bz-DMT-2'-O-propargyl-C-CE-Phosphoramidite

3'-O-Methyl Inosine CED phosphoramidite

Description: 3'-O-Methyl Inosine CED phosphoramidite is a modified inosine nucleotide used in oligonucleotide synthesis. It features a methyl group at the 3' position and a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is utilized to create stable and functionalized RNA and DNA sequences, facilitating advanced research in genetics and molecular biology.

CAT: BRP-01293

Molecular Formula: C41H49N6O8P

Molecular Weight: 784.84

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InChIKey: RBSDCCNFMPGPFZ-HLHZJIEZSA-N

IUPAC Name: (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-2-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H49N6O8P/c1-27(2)47(28(3)4)56(53-23-11-22-42)55-37-36(51-7)34(54-40(37)46-26-45-35-38(46)43-25-44-39(35)48)24-52-41(29-12-9-8-10-13-29,30-14-18-32(49-5)19-15-30)31-16-20-33(50-6)21-17-31/h8-10,12-21,25-28,34,36-37,40H,11,23-24H2,1-7H3,(H,43,44,48)/t34-,36-,37-,40-,56?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-methylinosine-2'-O-CED-phosphoramidite; 3'-OMe I 2'-amidite; 5'-O-(4,4'-dimethoxytrityl)-3'-O-methylinosine-2'-cyanoethyl phosphoramidite; 3'-O-Me-I-2'-phosphoramidite; 3'-OMe-I Phosphoramidite