What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - BOC Sciences

[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-uridine, coupled with a 2'-O-Me-guanosine featuring an isobutyryl (iBu) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01155

Molecular Formula: C58H72N10O17P2

Molecular Weight: 1243.21

Purity: ≥95% by HPLC

Appearance: White to off-white powder

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InChIKey: PJSNGMFTSNHPEB-DEECTFEXSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C58H72N10O17P2/c1-35(2)52(70)64-56-63-51-46(53(71)65-56)61-34-67(51)55-49(76-9)47(84-86(79-30-14-27-59)68(36(3)4)37(5)6)44(83-55)33-81-87(73,80-31-15-28-60)85-48-43(82-54(50(48)77-10)66-29-26-45(69)62-57(66)72)32-78-58(38-16-12-11-13-17-38,39-18-22-41(74-7)23-19-39)40-20-24-42(75-8)25-21-40/h11-13,16-26,29,34-37,43-44,47-50,54-55H,14-15,30-33H2,1-10H3,(H,62,69,72)(H2,63,64,65,70,71)/t43-,44-,47-,48-,49-,50-,54-,55-,86?,87?/m1/s1

Synonyms: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite]

[5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-cytidine with an acetyl (Ac) protecting group, coupled with a 2'-O-Me-guanosine featuring an isobutyryl (iBu) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01156

Molecular Formula: C60H75N11O17P2

Molecular Weight: 1284.27

Purity: ≥95% by HPLC

Appearance: White to off-white powder

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InChIKey: JREOEYAVHNOKMM-UWSVYRINSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C60H75N11O17P2/c1-36(2)54(73)67-58-66-53-48(55(74)68-58)63-35-70(53)57-51(79-10)49(87-89(82-31-15-28-61)71(37(3)4)38(5)6)46(86-57)34-84-90(76,83-32-16-29-62)88-50-45(85-56(52(50)80-11)69-30-27-47(64-39(7)72)65-59(69)75)33-81-60(40-17-13-12-14-18-40,41-19-23-43(77-8)24-20-41)42-21-25-44(78-9)26-22-42/h12-14,17-27,30,35-38,45-46,49-52,56-57H,15-16,31-34H2,1-11H3,(H,64,65,72,75)(H2,66,67,68,73,74)/t45-,46-,49-,50-,51-,52-,56-,57-,89?,90?/m1/s1

Synonyms: [5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite]

[5'-O-DMTr-2'-OMe-A(Bz)](P-thio-pCyEt) [2'-O-Me-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-A(Bz)](P-thio-pCyEt) [2'-O-Me-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-adenosine with a benzoyl (Bz) protecting group, coupled with a 2'-O-Me-adenosine also featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01157

Molecular Formula: C69H75N13O14P2S

Molecular Weight: 1404.44

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: XCGJIPXEZUXVNV-YKUGJANUSA-N

SMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OC)COP(=S)(OCCC#N)OC5C(OC(N6C=NC=7C(=NC=NC76)NC(=O)C=8C=CC=CC8)C5OC)COC(C=9C=CC=CC9)(C%10=CC=C(OC)C=C%10)C%11=CC=C(OC)C=C%11)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C69H75N13O14P2S/c1-44(2)82(45(3)4)97(90-36-18-34-70)95-57-54(94-67(59(57)87-7)80-42-76-55-61(72-40-74-63(55)80)78-65(83)46-20-12-9-13-21-46)39-92-98(99,91-37-19-35-71)96-58-53(93-68(60(58)88-8)81-43-77-56-62(73-41-75-64(56)81)79-66(84)47-22-14-10-15-23-47)38-89-69(48-24-16-11-17-25-48,49-26-30-51(85-5)31-27-49)50-28-32-52(86-6)33-29-50/h9-17,20-33,40-45,53-54,57-60,67-68H,18-19,36-39H2,1-8H3,(H,72,74,78,83)(H,73,75,79,84)/t53-,54-,57-,58-,59-,60-,67-,68-,97?,98?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-A(benzoyl)](P-thio-pCyEt) [2'-O-Me-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-OMe-A(Bz)](pCyEt) [2'-F-dA(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-A(Bz)](pCyEt) [2'-F-dA(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-adenosine with a benzoyl (Bz) protecting group, coupled with a 2'-fluoro-deoxyadenosine (2'-F-dA) also featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01158

Molecular Formula: C68H72FN13O14P2

Molecular Weight: 1376.35

Purity: ≥95% by HPLC

Appearance: White to off-white powder

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InChIKey: XJSBJPLHTAATIR-YKZUEJCGSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C68H72FN13O14P2/c1-43(2)82(44(3)4)97(90-35-17-33-70)95-57-53(93-66(54(57)69)80-41-76-55-60(72-39-74-62(55)80)78-64(83)45-19-11-8-12-20-45)38-92-98(85,91-36-18-34-71)96-58-52(94-67(59(58)88-7)81-42-77-56-61(73-40-75-63(56)81)79-65(84)46-21-13-9-14-22-46)37-89-68(47-23-15-10-16-24-47,48-25-29-50(86-5)30-26-48)49-27-31-51(87-6)32-28-49/h8-16,19-32,39-44,52-54,57-59,66-67H,17-18,35-38H2,1-7H3,(H,72,74,78,83)(H,73,75,79,84)/t52-,53-,54-,57-,58-,59-,66-,67-,97?,98?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-A(benzoyl)](pCyEt)[2'-Fluoro-dA(benzoyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-F-dC(Ac)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-F-dC(Ac)-3'-CE-Phosphoramidite] is a specialized building block used in the chemical synthesis of modified oligonucleotides. The modifications to the guanine and cytidine bases, including methoxy, fluoro, and protective groups, improve the properties of nucleic acids for research and therapeutic applications. This compound is significant in biochemical research and therapeutic development, contributing to advancements in genetic and molecular medicine.

CAT: BRP-01159

Molecular Formula: C59H72FN11O16P2

Molecular Weight: 1272.21

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: JWJXHOVUDQYNQH-FVZAZZLTSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C59H72FN11O16P2/c1-35(2)53(73)67-57-66-52-48(54(74)68-57)63-34-70(52)56-51(79-10)50(44(85-56)32-80-59(39-16-12-11-13-17-39,40-18-22-42(77-8)23-19-40)41-20-24-43(78-9)25-21-41)87-89(76,82-31-15-28-62)83-33-45-49(86-88(81-30-14-27-61)71(36(3)4)37(5)6)47(60)55(84-45)69-29-26-46(64-38(7)72)65-58(69)75/h11-13,16-26,29,34-37,44-45,47,49-51,55-56H,14-15,30-33H2,1-10H3,(H,64,65,72,75)(H2,66,67,68,73,74)/t44-,45-,47-,49-,50-,51-,55-,56-,88?,89?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-G(isobutyryl)](pCyEt)[2'-Fluoro-dC(acetyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, coupled with a 2'-O-Me-adenosine featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01160

Molecular Formula: C62H70FN11O15P2

Molecular Weight: 1290.25

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: FLVRUPWUNDBISN-QKVILFJXSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(6-benzamido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C62H70FN11O15P2/c1-39(2)74(40(3)4)90(83-33-15-30-64)88-54-49(87-60(55(54)81-8)73-38-68-52-56(66-37-67-57(52)73)71-58(76)42-17-11-9-12-18-42)36-85-91(78,84-34-16-31-65)89-53-48(86-59(51(53)63)72-32-29-50(69-41(5)75)70-61(72)77)35-82-62(43-19-13-10-14-20-43,44-21-25-46(79-6)26-22-44)45-23-27-47(80-7)28-24-45/h9-14,17-29,32,37-40,48-49,51,53-55,59-60H,15-16,33-36H2,1-8H3,(H,66,67,71,76)(H,69,70,75,77)/t48-,49-,51-,53-,54-,55-,59-,60-,90?,91?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-dC(acetyl)](pCyEt)[2'-O-methyl-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]; CfAm; [5'-O-DMTr-2'-F-C(Ac)](pCyEt)[2'-OMe dA(Bz)-3'-CE-Phosphoramidite]; [5'-O-DMTr-2'-F-C(Ac)](pCyEt)[2'-OMe_x005f_x0002_A(Bz)-3'-CE Phosphoramidite]

[5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group, coupled with a 2'-O-Me-adenosine also featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01161

Molecular Formula: C68H72FN13O14P2

Molecular Weight: 1376.35

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: IEMHYBRYTKNWOB-YKZUEJCGSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C68H72FN13O14P2/c1-43(2)82(44(3)4)97(90-35-17-33-70)95-58-53(94-67(59(58)88-7)81-42-77-56-61(73-40-75-63(56)81)79-65(84)46-21-13-9-14-22-46)38-92-98(85,91-36-18-34-71)96-57-52(93-66(54(57)69)80-41-76-55-60(72-39-74-62(55)80)78-64(83)45-19-11-8-12-20-45)37-89-68(47-23-15-10-16-24-47,48-25-29-50(86-5)30-26-48)49-27-31-51(87-6)32-28-49/h8-16,19-32,39-44,52-54,57-59,66-67H,17-18,35-38H2,1-7H3,(H,72,74,78,83)(H,73,75,79,84)/t52-,53-,54-,57-,58-,59-,66-,67-,97?,98?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyadenosine(benzoyl)](pCyEt)[2'-O-methyl-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-F-dG(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dG(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyguanosine (2'-F-dG) with an isobutyryl (iBu) protecting group, coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01162

Molecular Formula: C57H69FN10O16P2

Molecular Weight: 1231.16

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: XPODDDMZDAYSLB-DDOFDVFASA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H69FN10O16P2/c1-34(2)51(70)64-55-63-50-46(52(71)65-55)61-33-67(50)53-45(58)47(42(81-53)31-77-57(37-15-11-10-12-16-37,38-17-21-40(74-7)22-18-38)39-19-23-41(75-8)24-20-39)84-86(73,79-30-14-27-60)80-32-43-48(83-85(78-29-13-26-59)68(35(3)4)36(5)6)49(76-9)54(82-43)66-28-25-44(69)62-56(66)72/h10-12,15-25,28,33-36,42-43,45,47-49,53-54H,13-14,29-32H2,1-9H3,(H,62,69,72)(H2,63,64,65,70,71)/t42-,43-,45-,47-,48-,49-,53-,54-,85?,86?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyguanosine(isobutyryl)](pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-F-dG(iBu)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dG(iBu)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyguanosine (2'-F-dG) with an isobutyryl (iBu) protecting group, coupled with a 2'-O-Me-adenosine featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01163

Molecular Formula: C65H74FN13O15P2

Molecular Weight: 1358.33

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: LRTYNAWUQYQBND-XLCQULBRSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C65H74FN13O15P2/c1-39(2)59(80)75-64-74-58-52(61(82)76-64)72-38-78(58)62-50(66)53(48(91-62)34-87-65(43-20-14-11-15-21-43,44-22-26-46(84-7)27-23-44)45-24-28-47(85-8)29-25-45)94-96(83,89-33-17-31-68)90-35-49-54(93-95(88-32-16-30-67)79(40(3)4)41(5)6)55(86-9)63(92-49)77-37-71-51-56(69-36-70-57(51)77)73-60(81)42-18-12-10-13-19-42/h10-15,18-29,36-41,48-50,53-55,62-63H,16-17,32-35H2,1-9H3,(H,69,70,73,81)(H2,74,75,76,80,82)/t48-,49-,50-,53-,54-,55-,62-,63-,95?,96?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyguanosine(isobutyryl)](pCyEt)[2'-O-methyl-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-F-dU](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dU](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyuridine (2'-F-dU), coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01164

Molecular Formula: C52H62FN7O16P2

Molecular Weight: 1122.05

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: HHTCFGCOBNOOGE-OSAWNNERSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H62FN7O16P2/c1-33(2)60(34(3)4)77(70-29-11-25-54)75-46-41(74-49(47(46)68-7)59-28-24-43(62)57-51(59)64)32-72-78(65,71-30-12-26-55)76-45-40(73-48(44(45)53)58-27-23-42(61)56-50(58)63)31-69-52(35-13-9-8-10-14-35,36-15-19-38(66-5)20-16-36)37-17-21-39(67-6)22-18-37/h8-10,13-24,27-28,33-34,40-41,44-49H,11-12,29-32H2,1-7H3,(H,56,61,63)(H,57,62,64)/t40-,41-,44-,45-,46-,47-,48-,49-,77?,78?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyuridine](pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]; UfUm; [5'-O-DMTr-2'-F-U](pCyEt)[2'-OMe-U-3'-CE Phosphoramidite]

[5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group, coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01165

Molecular Formula: C60H67FN10O15P2

Molecular Weight: 1249.20

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: MLTDAQATQGSCMC-YJAGKEHNSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C60H67FN10O15P2/c1-38(2)71(39(3)4)87(80-32-14-29-62)85-52-47(84-58(53(52)78-7)69-31-28-48(72)67-59(69)74)35-82-88(75,81-33-15-30-63)86-51-46(83-57(49(51)61)70-37-66-50-54(64-36-65-55(50)70)68-56(73)40-16-10-8-11-17-40)34-79-60(41-18-12-9-13-19-41,42-20-24-44(76-5)25-21-42)43-22-26-45(77-6)27-23-43/h8-13,16-28,31,36-39,46-47,49,51-53,57-58H,14-15,32-35H2,1-7H3,(H,67,72,74)(H,64,65,68,73)/t46-,47-,49-,51-,52-,53-,57-,58-,87?,88?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyadenosine(benzoyl)](pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]; AfUm; [5'-O-DMTr-2'-F A(Bz)](pCyEt)[2'-OMe-U-3'-CE Phosphoramidite]

[5'-O-DMTr-2'-F-dU](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dU](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyuridine (2'-F-dU), coupled with a 2'-O-Me-adenosine featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01166

Molecular Formula: C60H67FN10O15P2

Molecular Weight: 1249.20

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: MXFDTLAJATVWHH-YJAGKEHNSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C60H67FN10O15P2/c1-38(2)71(39(3)4)87(80-32-14-29-62)85-52-47(84-58(53(52)78-7)70-37-66-50-54(64-36-65-55(50)70)68-56(73)40-16-10-8-11-17-40)35-82-88(75,81-33-15-30-63)86-51-46(83-57(49(51)61)69-31-28-48(72)67-59(69)74)34-79-60(41-18-12-9-13-19-41,42-20-24-44(76-5)25-21-42)43-22-26-45(77-6)27-23-43/h8-13,16-28,31,36-39,46-47,49,51-53,57-58H,14-15,32-35H2,1-7H3,(H,67,72,74)(H,64,65,68,73)/t46-,47-,49-,51-,52-,53-,57-,58-,87?,88?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyuridine](pCyEt)[2'-O-methyl-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]; UfAm; [5'-O-DMTr-2'-F-U](pCyEt)[2'-OMe-A(Bz)-3'-CE Phosphoramidite]

[5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01167

Molecular Formula: C54H65FN8O16P2

Molecular Weight: 1163.10

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: VRMGJNPMTYRHKS-JFJKBCMNSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H65FN8O16P2/c1-34(2)63(35(3)4)80(73-30-12-26-56)78-48-43(77-51(49(48)71-8)62-29-25-45(65)60-53(62)67)33-75-81(68,74-31-13-27-57)79-47-42(76-50(46(47)55)61-28-24-44(58-36(5)64)59-52(61)66)32-72-54(37-14-10-9-11-15-37,38-16-20-40(69-6)21-17-38)39-18-22-41(70-7)23-19-39/h9-11,14-25,28-29,34-35,42-43,46-51H,12-13,30-33H2,1-8H3,(H,60,65,67)(H,58,59,64,66)/t42-,43-,46-,47-,48-,49-,50-,51-,80?,81?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-dC(acetyl)](pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]

2-Cyanoethyl (6-(3-(prop-2-yn-1-yloxy)-2,2-bis((prop-2-yn-1-yloxy)methyl)propoxy)hexyl) diisopropylphosphoramidite

Description: This phosphoramidite is utilized in solid-phase oligonucleotide synthesis. The cyanoethyl group protects the phosphate backbone during synthesis, while the complex linker (prop-2-yn-1-yloxy and propoxy groups) allows for the attachment of nucleoside units. This modification facilitates the creation of oligonucleotides with specific functionalities and structures for various research and therapeutic applications.

CAT: BRP-01168

Molecular Formula: C29H47N2O6P

Molecular Weight: 550.68

Purity: ≥98% by HPLC

Appearance: Colorless, pale yellow to yellow oily matter

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InChIKey: UGCIERZKKRAEPJ-UHFFFAOYSA-N

SMILES: N#CCCOP(OCCCCCCOCC(COCC#C)(COCC#C)COCC#C)N(C(C)C)C(C)C

InChI: InChI=1S/C29H47N2O6P/c1-8-17-32-23-29(24-33-18-9-2,25-34-19-10-3)26-35-20-13-11-12-14-21-36-38(37-22-15-16-30)31(27(4)5)28(6)7/h1-3,27-28H,11-15,17-26H2,4-7H3

TEG-GalNAc Cluster Amidite

Description: TEG-GalNAc amidite is employed in the synthesis of oligonucleotides conjugated with GalNAc clusters. GalNAc conjugation facilitates targeted delivery of oligonucleotides to hepatocytes, enhancing therapeutic efficacy in treatments for liver-related diseases such as familial hypercholesterolemia and hepatic cancers.

CAT: BRP-01169

Molecular Formula: C61H89N4O19P

Molecular Weight: 1213.37

Purity: ≥97%

Appearance: White to light yellow powder

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InChIKey: ZBBIFTGXXMNXRH-CKGCLIAUSA-N

SMILES: CC(O[C@H]([C@H]([C@@H]1OCCCCC(NCCCOCCOCCOCCOCC(OP(OCCC#N)N(C(C)C)C(C)C)COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)=O)NC(C)=O)[C@H]([C@H](O1)COC(C)=O)OC(C)=O)=O

IUPAC Name: (2R,3R,4R,5R,6R)-5-acetamido-2-(acetoxymethyl)-6-((4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-1,1-bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azatetracosan-24-yl)oxy)tetrahydro-2H-pyran-3,4-diyl diacetate

InChI: InChI=1S/C61H89N4O19P/c1-43(2)65(44(3)4)85(80-33-16-29-62)84-54(41-79-61(49-18-12-11-13-19-49,50-21-25-52(71-9)26-22-50)51-23-27-53(72-10)28-24-51)40-76-39-38-75-37-36-74-35-34-73-31-17-30-63-56(70)20-14-15-32-77-60-57(64-45(5)66)59(82-48(8)69)58(81-47(7)68)55(83-60)42-78-46(6)67/h11-13,18-19,21-28,43-44,54-55,57-60H,14-17,20,30-42H2,1-10H3,(H,63,70)(H,64,66)/t54?,55-,57-,58+,59-,60-,85?/m1/s1

Synonyms: GalNAc PEG Cluster Phosphoramidite; Tetraethylene glycol-N-acetylgalactosamine Amidite

DMTr-hydroxymethyl hexyl-Biotin Phosphoramidite

Description: This phosphoramidite incorporates biotin linked via a hydroxymethyl hexyl spacer, protected with a dimethoxytrityl (DMTr) group. Biotin is widely used in biochemical assays for affinity purification, protein detection, and as a molecular tag in nucleic acid hybridization studies. This modification enables specific and sensitive detection and isolation of biotinylated oligonucleotides or biomolecules.

CAT: BRP-01170

CAS: 1021702-07-7

Molecular Formula: C47H66N5O7PS

Molecular Weight: 876.11

Purity: ≥97% by UPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: GMVCCUAXEMZEJE-OYSBNFJTSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(CCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]pentanamide

InChI: InChI=1S/C47H66N5O7PS/c1-34(2)52(35(3)4)60(58-30-14-28-48)59-32-36(15-12-13-29-49-44(53)19-11-10-18-43-45-42(33-61-43)50-46(54)51-45)31-57-47(37-16-8-7-9-17-37,38-20-24-40(55-5)25-21-38)39-22-26-41(56-6)27-23-39/h7-9,16-17,20-27,34-36,42-43,45H,10-15,18-19,29-33H2,1-6H3,(H,49,53)(H2,50,51,54)/t36?,42-,43-,45-,60?/m0/s1

Synonyms: DMTr-hydroxymethyl hexyl-Biotin Phosphoramidite; 2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl ester

1,3-di-O-DMTr-glycerol-bis-(diisopropylamino)-Phosphane

Description: This phosphoramidite features a glycerol backbone modified with two DMTr groups and diisopropylamino phosphane groups. It facilitates efficient coupling reactions during solid-phase oligonucleotide synthesis, ensuring high purity and yield. The glycerol spacer enhances solubility and stability of synthesized oligonucleotides, crucial for applications in diagnostics, therapeutics, and biochemical research.

CAT: BRP-01171

Molecular Formula: C57H71N2O7P

Molecular Weight: 927.18

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: YMXVZHWMLGEXDA-UHFFFAOYSA-N

SMILES: CC(N(P(N(C(C)C)C(C)C)OC(COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)C(C)C)C

IUPAC Name: 1-((1,3-bis(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl)oxy)-N,N,N',N'-tetraisopropylphosphanediamine

InChI: InChI=1S/C57H71N2O7P/c1-41(2)58(42(3)4)67(59(43(5)6)44(7)8)66-55(39-64-56(45-19-15-13-16-20-45,47-23-31-51(60-9)32-24-47)48-25-33-52(61-10)34-26-48)40-65-57(46-21-17-14-18-22-46,49-27-35-53(62-11)36-28-49)50-29-37-54(63-12)38-30-50/h13-38,41-44,55H,39-40H2,1-12H3

Synonyms: 1,3-di-O-(4,4'-dimethoxytrityl)-glycerol-bis-(diisopropylamino)-Phosphane

NHMMTr-C8 Phosphoramidite

Description: NHMMTr (N-methyl-N-(4-methoxy-2,4-dimethylphenyl)aminoethyl) linked to an octyl chain serves as a phosphoramidite for oligonucleotide synthesis. This modification improves the stability and hybridization properties of synthesized oligonucleotides, making them suitable for applications such as antisense therapy, gene silencing, and diagnostics.

CAT: BRP-01172

Molecular Formula: C37H52N3O3P

Molecular Weight: 617.81

Purity: ≥97% by UPLC

Appearance: Colorless to light yellow oily matter

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InChIKey: WQNVNSOXLICQQJ-UHFFFAOYSA-N

SMILES: N#CCCOP(N(C(C)C)C(C)C)OCCCCCCCCNC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3

IUPAC Name: 2-cyanoethyl (8-(((4-methoxyphenyl)diphenylmethyl)amino)octyl) diisopropylphosphoramidite

InChI: InChI=1S/C37H52N3O3P/c1-31(2)40(32(3)4)44(43-30-18-27-38)42-29-17-9-7-6-8-16-28-39-37(33-19-12-10-13-20-33,34-21-14-11-15-22-34)35-23-25-36(41-5)26-24-35/h10-15,19-26,31-32,39H,6-9,16-18,28-30H2,1-5H3

Synonyms: Monomethoxytrityl-octylamine-linker Phosphoramidite; MMTr C8 amine amidite

12-O-DMTr-dodecane-bis-(diisopropylamino)-Phosphane

Description: This phosphoramidite incorporates a dodecane spacer with two DMTr groups and diisopropylamino phosphane groups. It facilitates the attachment of nucleoside units during oligonucleotide synthesis, ensuring efficient coupling and high purity of the final product. The dodecane spacer provides flexibility and stability to synthesized oligonucleotides, essential for biomedical and research applications.

CAT: BRP-01173

Molecular Formula: C45H71N2O4P

Molecular Weight: 735.05

Purity: ≥97% by HPLC

Appearance: Colorless to light yellow oily matter

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InChIKey: RQZBDCUKNIMBGS-UHFFFAOYSA-N

SMILES: CC(N(C(C)C)P(OCCCCCCCCCCCCOC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=C(C=C3)OC)N(C(C)C)C(C)C)C

IUPAC Name: 1-((12-(bis(4-methoxyphenyl)(phenyl)methoxy)dodecyl)oxy)-N,N,N',N'-tetraisopropylphosphanediamine

InChI: InChI=1S/C45H71N2O4P/c1-36(2)46(37(3)4)52(47(38(5)6)39(7)8)51-35-23-18-16-14-12-11-13-15-17-22-34-50-45(40-24-20-19-21-25-40,41-26-30-43(48-9)31-27-41)42-28-32-44(49-10)33-29-42/h19-21,24-33,36-39H,11-18,22-23,34-35H2,1-10H3

Synonyms: 12-O-(4,4'-dimethoxytrityl)-dodecane-bis-(diisopropylamino)-Phosphane

N-Butyl-2-cyanoethyl-N,N-diisopropylphosphoramidite

Description: This phosphoramidite derivative contains a butyl group, cyanoethyl protecting group, and diisopropylphosphoramidite functionality for coupling nucleoside units in oligonucleotide synthesis. It enhances the efficiency and specificity of nucleotide incorporation, enabling the synthesis of customized oligonucleotides for gene expression studies, RNA interference, and therapeutic applications.

CAT: BRP-01174

CAS: 887265-03-4

Molecular Formula: C13H27N2O2P

Molecular Weight: 274.34

Purity: >95%

Appearance: Colorless to light yellow oily matter

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InChIKey: IICOXFTVYLVMBH-UHFFFAOYSA-N

SMILES: CCCCOP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[butoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C13H27N2O2P/c1-6-7-10-16-18(17-11-8-9-14)15(12(2)3)13(4)5/h12-13H,6-8,10-11H2,1-5H3

Synonyms: Butyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, butyl 2-cyanoethyl ester; Butyl (2-cyanoethyl) diisopropylphosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, butyl 2-cyanoethyl ester