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Phosphoramidites

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2'-Modified Phosphoramidites
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2,6-diamino(N2,N6-diiBu)-DMT-2'-O-MOE-purine riboside-CE-Phosphoramidite

Description: This phosphoramidite introduces a purine riboside nucleoside modified with 2,6-diamino groups at the N2 and N6 positions, protected with a dimethoxytrityl (DMT) group at the 5'-position, and a methoxyethyl (MOE) group at the 2'-position. Such modifications can enhance RNA binding affinity and stability, useful in RNA structure studies and therapeutic RNA design.
CAT: BRP-01123
Molecular Formula: C51H67N8O10P
Molecular Weight: 983.10
Purity: ≥90% by HPLC
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: NHUMZBQEINRZEF-RTHUGTBQSA-N
CanonicalSMILES: CC(C)C(=O)NC1=C2C(=NC(=N1)NC(=O)C(C)C)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC
IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-methoxyethoxy)oxolan-2-yl]-2-(2-methylpropanoylamino)purin-6-yl]-2-methylpropanamide
InChI: InChI=1S/C51H67N8O10P/c1-32(2)47(60)54-45-42-46(56-50(55-45)57-48(61)33(3)4)58(31-53-42)49-44(65-29-28-62-9)43(69-70(67-27-15-26-52)59(34(5)6)35(7)8)41(68-49)30-66-51(36-16-13-12-14-17-36,37-18-22-39(63-10)23-19-37)38-20-24-40(64-11)25-21-38/h12-14,16-25,31-35,41,43-44,49H,15,27-30H2,1-11H3,(H2,54,55,56,57,60,61)/t41-,43-,44-,49-,70?/m1/s1
Synonyms: 2,6-diamino(N2,N6-diisobutyryl)-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-purine riboside-3'-cyanoethyl Phosphoramidite; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,6-diisobutyramido-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-DMT-2'-O-NMA-5-Me-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside modified with a dimethoxytrityl (DMT) group at the 5'-position, a 2'-O-N-methylamino (NMA) group, and a methyl group at the 5-position, protected with a cyanoethyl (CE) group at the 3'-position. This modification can influence RNA structure and function, including RNA-protein interactions and stability.
CAT: BRP-01124
CAS: 1025783-16-7
Molecular Formula: C43H54N5O10P
Molecular Weight: 831.89
Purity: ≥98% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: FYNKMLIMLHVWST-FMMLDEGOSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=O)NC2=O)C)C1OCC(=O)NC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H54N5O10P/c1-28(2)48(29(3)4)59(56-24-12-23-44)58-38-36(57-41(39(38)54-27-37(49)45-6)47-25-30(5)40(50)46-42(47)51)26-55-43(31-13-10-9-11-14-31,32-15-19-34(52-7)20-16-32)33-17-21-35(53-8)22-18-33/h9-11,13-22,25,28-29,36,38-39,41H,12,24,26-27H2,1-8H3,(H,45,49)(H,46,50,51)/t36-,38-,39-,41-,59?/m1/s1
Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-5-methyluridine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite; 2'-O-NMA 5-Me-U amidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-CE-Phosphoramidite

Description: 5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-CE-Phosphoramidite is a modified adenine nucleoside phosphoramidite used in DNA and RNA synthesis. It features a DMTr (dimethoxytrityl) protecting group at the 5' position, a TMBTM (trimethoxybenzylthiomethyl) group at the 2' position, and a benzoyl-protected adenine base. This compound is essential for the synthesis of oligonucleotides with enhanced stability and functionality for use in genetic research and biotechnology.
CAT: BRP-01125
Molecular Formula: C58H66N7O11PS
Molecular Weight: 1100.24
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: XJUICBHZUQLUOH-WMPDMCAKSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C58H66N7O11PS/c1-38(2)65(39(3)4)77(74-30-16-29-59)76-52-50(33-73-58(41-19-14-11-15-20-41,42-21-25-44(67-5)26-22-42)43-23-27-45(68-6)28-24-43)75-57(53(52)72-37-78-34-47-48(70-8)31-46(69-7)32-49(47)71-9)64-36-62-51-54(60-35-61-55(51)64)63-56(66)40-17-12-10-13-18-40/h10-15,17-28,31-32,35-36,38-39,50,52-53,57H,16,30,33-34,37H2,1-9H3,(H,60,61,63,66)/t50-,52-,53-,57-,77?/m1/s1
Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-adenosine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-C(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a cytidine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a dimethoxytrityl (DMTr) group at the 5'-position. It is also modified with a benzoyl (Bz) group at the 3'-position and protected with a cyanoethyl (CE) group. Such modifications can enhance RNA stability and specificity in biochemical and therapeutic applications.
CAT: BRP-01126
CAS: 2253978-43-5
Molecular Formula: C57H66N5O12PS
Molecular Weight: 1076.21
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: JILKHWGHHKCHDX-LEGKXAINSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OCSCC=4C(OC)=CC(OC)=CC4OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C57H66N5O12PS/c1-38(2)62(39(3)4)75(72-32-16-30-58)74-52-50(35-71-57(41-19-14-11-15-20-41,42-21-25-44(65-5)26-22-42)43-23-27-45(66-6)28-24-43)73-55(61-31-29-51(60-56(61)64)59-54(63)40-17-12-10-13-18-40)53(52)70-37-76-36-47-48(68-8)33-46(67-7)34-49(47)69-9/h10-15,17-29,31,33-34,38-39,50,52-53,55H,16,32,35-37H2,1-9H3,(H,59,60,63,64)/t50-,52-,53-,55-,75?/m1/s1
Synonyms: N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-cytidine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-G(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a guanosine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a DMTr group at the 5'-position. It is modified with an isobutyryl (iBu) group at the 3'-position and protected with a CE group. Modifications like these can enhance RNA structure and function, impacting gene expression and regulatory mechanisms.
CAT: BRP-01127
CAS: 2253978-42-4
Molecular Formula: C55H68N7O12PS
Molecular Weight: 1082.22
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: ZUFAHXPFYJOCTP-DRQNSODDSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OCSCC=4C(OC)=CC(OC)=CC4OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C55H68N7O12PS/c1-34(2)51(63)59-54-58-50-47(52(64)60-54)57-32-61(50)53-49(70-33-76-31-43-44(68-10)28-42(67-9)29-45(43)69-11)48(74-75(72-27-15-26-56)62(35(3)4)36(5)6)46(73-53)30-71-55(37-16-13-12-14-17-37,38-18-22-40(65-7)23-19-38)39-20-24-41(66-8)25-21-39/h12-14,16-25,28-29,32,34-36,46,48-49,53H,15,27,30-31,33H2,1-11H3,(H2,58,59,60,63,64)/t46-,48-,49-,53-,75?/m1/s1
Synonyms: N2-isobutyryl-5'-O-4,4'-(dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-guanosine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a DMTr group at the 5'-position. It is modified with a uracil base at the 3'-position and protected with a CE group. Modifications like these are useful in RNA research to study RNA-protein interactions and enzymatic processes.
CAT: BRP-01128
CAS: 1449578-46-4
Molecular Formula: C50H61N4O12PS
Molecular Weight: 973.09
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: JNQQDMGQFJAHSP-NCVHJKQYSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCSCC2=C(C=C(C=C2OC)OC)OC)N3C=CC(=O)NC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-[(2,4,6-trimethoxyphenyl)methylsulfanylmethoxy]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C50H61N4O12PS/c1-33(2)54(34(3)4)67(64-27-13-25-51)66-46-44(30-63-50(35-14-11-10-12-15-35,36-16-20-38(57-5)21-17-36)37-18-22-39(58-6)23-19-37)65-48(53-26-24-45(55)52-49(53)56)47(46)62-32-68-31-41-42(60-8)28-40(59-7)29-43(41)61-9/h10-12,14-24,26,28-29,33-34,44,46-48H,13,27,30-32H2,1-9H3,(H,52,55,56)/t44-,46-,47-,48-,67?/m1/s1
Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-uridine-3'-cyanoethyl Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[(2,4,6-trimethoxyphenyl)methyl]thio]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-Trifluoroacetamido propyl-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is protected with a CE group at the 3'-position. Such modifications can alter RNA stability and interactions with other molecules in biochemical studies.
CAT: BRP-01129
CAS: 165381-49-7
Molecular Formula: C44H53F3N5O10P
Molecular Weight: 899.90
Purity: ≥97% by UPLC
Appearance: White, off-white to light yellow powder
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InChIKey: JDBCEYQBKYYZNE-OVLVZACUSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCCNC(=O)C(F)(F)F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: N-[3-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxypropyl]-2,2,2-trifluoroacetamide
InChI: InChI=1S/C44H53F3N5O10P/c1-29(2)52(30(3)4)63(60-27-10-23-48)62-38-36(61-40(51-25-22-37(53)50-42(51)55)39(38)58-26-11-24-49-41(54)44(45,46)47)28-59-43(31-12-8-7-9-13-31,32-14-18-34(56-5)19-15-32)33-16-20-35(57-6)21-17-33/h7-9,12-22,25,29-30,36,38-40H,10-11,24,26-28H2,1-6H3,(H,49,54)(H,50,53,55)/t36-,38-,39-,40-,63?/m1/s1
Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-uridine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[3-[(trifluoroacetyl)amino]propyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-O-Trifluoroacetamido propyl Uridine CED phosphoramidite

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-G(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a guanosine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is modified with an isobutyryl (iBu) group at the 3'-position and protected with a CE group. Modifications like these can enhance RNA binding affinity and stability.
CAT: BRP-01130
Molecular Formula: C49H60F3N8O10P
Molecular Weight: 1009.03
Purity: ≥97% by UPLC
Appearance: White, off-white to light yellow powder
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InChIKey: HSHKDSSCDQGICM-WYWHGLPISA-N
CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCCNC(=O)C(F)(F)F
IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[3-[(2,2,2-trifluoroacetyl)amino]propoxy]oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
InChI: InChI=1S/C49H60F3N8O10P/c1-30(2)43(61)57-47-56-42-39(44(62)58-47)55-29-59(42)45-41(66-26-13-25-54-46(63)49(50,51)52)40(70-71(68-27-12-24-53)60(31(3)4)32(5)6)38(69-45)28-67-48(33-14-10-9-11-15-33,34-16-20-36(64-7)21-17-34)35-18-22-37(65-8)23-19-35/h9-11,14-23,29-32,38,40-41,45H,12-13,25-28H2,1-8H3,(H,54,63)(H2,56,57,58,61,62)/t38-,40-,41-,45-,71?/m1/s1
Synonyms: N2-isobutyryl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(3-(2,2,2-trifluoroacetamido)propoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-C(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a cytidine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is modified with a benzoyl (Bz) group at the 3'-position and protected with a CE group. Such modifications can influence RNA structure and function in biochemical and therapeutic applications.
CAT: BRP-01131
CAS: 165381-54-4
Molecular Formula: C51H58F3N6O10P
Molecular Weight: 1003.03
Purity: ≥97% by UPLC
Appearance: White, off-white to light yellow powder
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InChIKey: PLGRAOCWBZAGHT-YJGWTFTBSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCCNC(=O)C(F)(F)F)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[3-[(2,2,2-trifluoroacetyl)amino]propoxy]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C51H58F3N6O10P/c1-34(2)60(35(3)4)71(68-32-13-28-55)70-44-42(33-67-50(37-17-11-8-12-18-37,38-19-23-40(64-5)24-20-38)39-21-25-41(65-6)26-22-39)69-47(45(44)66-31-14-29-56-48(62)51(52,53)54)59-30-27-43(58-49(59)63)57-46(61)36-15-9-7-10-16-36/h7-12,15-27,30,34-35,42,44-45,47H,13-14,29,31-33H2,1-6H3,(H,56,62)(H,57,58,61,63)/t42-,44-,45-,47-,71?/m1/s1
Synonyms: N4-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; N4-Benzoyl-5'-O-DMTr-2'-O-(N3-trifluoroacetyl)cytidine 3'-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[3-[(trifluoroacetyl)amino]propyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-O-Trifluoroacetamido propyl Cytidine CED phosphoramidite

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-A(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces an adenosine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is modified with a benzoyl (Bz) group at the 3'-position and protected with a CE group. Modifications like these are important for RNA research, enabling the study of RNA structure and function in various biological contexts.
CAT: BRP-01132
Molecular Formula: C52H58F3N8O9P
Molecular Weight: 1027.05
Purity: ≥97% by UPLC
Appearance: White, off-white to light yellow powder
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InChIKey: FDFXBSKFDLJDCP-DTABEXQVSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(3-(2,2,2-trifluoroacetamido)propoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C52H58F3N8O9P/c1-34(2)63(35(3)4)73(70-30-13-27-56)72-44-42(31-69-51(37-17-11-8-12-18-37,38-19-23-40(66-5)24-20-38)39-21-25-41(67-6)26-22-39)71-49(45(44)68-29-14-28-57-50(65)52(53,54)55)62-33-60-43-46(58-32-59-47(43)62)61-48(64)36-15-9-7-10-16-36/h7-12,15-26,32-35,42,44-45,49H,13-14,28-31H2,1-6H3,(H,57,65)(H,58,59,61,64)/t42-,44-,45-,49-,73?/m1/s1
Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

5'-O-DMTr-2'-ara-OAc-I-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces an inosine nucleoside where the 2'-hydroxyl group is modified with an arabinose acetyl (ara-OAc) group and protected with a DMTr group at the 5'-position. It is protected with a CE group at the 3'-position. Such modifications are used in RNA synthesis to study RNA modifications and their effects on RNA structure and function.
CAT: BRP-01133
CAS: 1449326-35-5
Molecular Formula: C42H49N6O9P
Molecular Weight: 812.86
Purity: ≥95% by HPLC
Appearance: Colorless to light yellow crystalline or white,off-white to light yellow amorphous dry powder
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InChIKey: LDSVRAQLSNCVSP-OOPWZCSESA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=CNC32)C1OC(=O)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (2R,3S,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl acetate
InChI: InChI=1S/C42H49N6O9P/c1-27(2)48(28(3)4)58(54-23-11-22-43)57-37-35(56-41(38(37)55-29(5)49)47-26-46-36-39(47)44-25-45-40(36)50)24-53-42(30-12-9-8-10-13-30,31-14-18-33(51-6)19-15-31)32-16-20-34(52-7)21-17-32/h8-10,12-21,25-28,35,37-38,41H,11,23-24H2,1-7H3,(H,44,45,50)/t35-,37-,38+,41-,58?/m1/s1
Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-actyl-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; 9-[2-O-Acetyl-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-arabinofuranosyl]-1,9-dihydro-6H-purin-6-one

5'-O-DMTr-2'-ara-OMe-I-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces an inosine nucleoside where the 2'-hydroxyl group is modified with an arabinose methyl (ara-OMe) group and protected with a DMTr group at the 5'-position. It is protected with a CE group at the 3'-position. Modifications like these are utilized in RNA research to investigate RNA modifications and their roles in gene expression and disease mechanisms.
CAT: BRP-01134
Molecular Formula: C41H49N6O8P
Molecular Weight: 784.85
Purity: ≥95% by HPLC
Appearance: Colorless to light yellow crystalline or white,off-white to light yellow amorphous dry powder
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InChIKey: PVFNTYBGWVZMCX-LSYABVRWSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=CNC32)C1OC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C41H49N6O8P/c1-27(2)47(28(3)4)56(53-23-11-22-42)55-36-34(54-40(37(36)51-7)46-26-45-35-38(46)43-25-44-39(35)48)24-52-41(29-12-9-8-10-13-29,30-14-18-32(49-5)19-15-30)31-16-20-33(50-6)21-17-31/h8-10,12-21,25-28,34,36-37,40H,11,23-24H2,1-7H3,(H,43,44,48)/t34-,36-,37+,40-,56?/m1/s1
Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; Arainosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-C(Ac)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-C(Ac)-3'-CE-Phosphoramidite] is a chemically modified nucleoside phosphoramidite used in the synthesis of stable and resistant oligonucleotides. The modifications, including the 2'-O-methyl, phosphorothioate, and various protecting groups, enhance the stability, binding affinity, and resistance to degradation of the resulting oligonucleotides. This makes it a valuable tool in biochemical research and therapeutic development.
CAT: BRP-01135
Molecular Formula: C57H71N9O16P2S
Molecular Weight: 1232.25
Purity: ≥95% by HPLC
Appearance: White, off-white to light yellow powder
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InChIKey: DZYQPLFPNVDNBI-OERPVMKOSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C57H71N9O16P2S/c1-36(2)66(37(3)4)83(76-32-14-28-58)81-49-46(80-53(51(49)73-9)64-30-26-47(60-38(5)67)62-55(64)69)35-78-84(85,77-33-15-29-59)82-50-45(79-54(52(50)74-10)65-31-27-48(61-39(6)68)63-56(65)70)34-75-57(40-16-12-11-13-17-40,41-18-22-43(71-7)23-19-41)42-20-24-44(72-8)25-21-42/h11-13,16-27,30-31,36-37,45-46,49-54H,14-15,32-35H2,1-10H3,(H,60,62,67,69)(H,61,63,68,70)/t45-,46-,49-,50-,51-,52-,53-,54-,83?,84?/m1/s1
Synonyms: [5'-O-DMTr-2'-O-Me-C(Ac)](P-thio-pCyEt)[2'-O-Me-C(Ac)-3'-CE-Phosphoramidite

DMO-4AG-N,N-dimethyl phosphoramidochloridate

Description: DMO-4AG-N,N-dimethyl phosphoramidochloridate is a reagent used in oligonucleotide synthesis, featuring a 4-amino group on the nucleobase and a dimethyl phosphoramidochloridate group. This reagent facilitates the introduction of specific phosphoramidite functionalities, enhancing the stability and binding affinity of the synthesized oligonucleotides.
CAT: BRP-01136
Molecular Formula: C62H68ClN15O11P2
Molecular Weight: 1296.72
Purity: ≥98% by HPLC
Appearance: White, off-white to light yellow powder
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InChIKey: JLONTSADQKXEQI-PIVCNVESSA-N
IUPAC Name: ((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-((dimethylamino)(((2S,6R)-6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)phosphoryl)morpholin-2-yl)methyl dimethylphosphoramidochloridate
InChI: InChI=1S/C62H68ClN15O11P2/c1-42(2)58(79)70-61-69-57-54(60(71-61)85-32-31-43-27-29-48(30-28-43)78(81)82)67-41-77(57)51-35-74(62(45-21-13-8-14-22-45,46-23-15-9-16-24-46)47-25-17-10-18-26-47)33-49(88-51)38-87-91(84,73(5)6)75-34-50(37-86-90(63,83)72(3)4)89-52(36-75)76-40-66-53-55(64-39-65-56(53)76)68-59(80)44-19-11-7-12-20-44/h7-30,39-42,49-52H,31-38H2,1-6H3,(H,64,65,68,80)(H,69,70,71,79)/t49-,50-,51+,52+,90?,91?/m0/s1
Synonyms: DMO-4AG-N,N-dimethyl phosphoramidochloridate

[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. The modifications, including 2'-O-methyl, phosphorothioate, and protective groups like DMTr, acetyl, and isobutyryl, enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic development.
CAT: BRP-01137
Molecular Formula: C60H75N11O16P2S
Molecular Weight: 1300.33
Purity: ≥95% by HPLC
Appearance: White, off-white to light yellow powder
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InChIKey: WVXVWJZTQGZYKP-AITXLTLESA-N
IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C60H75N11O16P2S/c1-36(2)54(73)67-58-66-53-48(55(74)68-58)63-35-70(53)57-51(78-10)49(86-88(81-31-15-28-61)71(37(3)4)38(5)6)46(85-57)34-83-89(90,82-32-16-29-62)87-50-45(84-56(52(50)79-11)69-30-27-47(64-39(7)72)65-59(69)75)33-80-60(40-17-13-12-14-18-40,41-19-23-43(76-8)24-20-41)42-21-25-44(77-9)26-22-42/h12-14,17-27,30,35-38,45-46,49-52,56-57H,15-16,31-34H2,1-11H3,(H,64,65,72,75)(H2,66,67,68,73,74)/t45-,46-,49-,50-,51-,52-,56-,57-,88?,89?/m1/s1
Synonyms: [5'-O-DMTr-2'-O-Me-C(Ac)](P-thio-pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite

[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a chemically modified nucleoside phosphoramidite used in the synthesis of oligonucleotides. The modifications, including 2'-O-methyl, phosphorothioate, and various protecting groups like DMTr and acetyl, enhance the stability, binding affinity, and resistance to degradation of the resulting oligonucleotides. This makes it a valuable tool for biochemical research and therapeutic development.
CAT: BRP-01138
Molecular Formula: C55H68N8O16P2S
Molecular Weight: 1191.20
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: SPDNYGNFSNICHW-SZYQAGCUSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C55H68N8O16P2S/c1-35(2)63(36(3)4)80(73-31-13-27-56)78-47-44(77-51(49(47)70-8)62-30-26-46(65)60-54(62)67)34-75-81(82,74-32-14-28-57)79-48-43(76-52(50(48)71-9)61-29-25-45(58-37(5)64)59-53(61)66)33-72-55(38-15-11-10-12-16-38,39-17-21-41(68-6)22-18-39)40-19-23-42(69-7)24-20-40/h10-12,15-26,29-30,35-36,43-44,47-52H,13-14,31-34H2,1-9H3,(H,60,65,67)(H,58,59,64,66)/t43-,44-,47-,48-,49-,50-,51-,52-,80?,81?/m1/s1
Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-C(acetyl)](P-thio-pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]

DMO-4AA-N,N-dimethyl phosphoramidochloridate

Description: DMO-4AA-N,N-dimethyl phosphoramidochloridate is a reagent used in oligonucleotide synthesis. It features a 4-amino group on the nucleobase and a dimethyl phosphoramidochloridate group, facilitating the introduction of specific phosphoramidite functionalities. This enhances the chemical stability and hybridization properties of the synthesized oligonucleotides, making it valuable for research and therapeutic applications.
CAT: BRP-01139
Molecular Formula: C57H59ClN14O8P2
Molecular Weight: 1165.59
Purity: ≥95% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: DFGOMKBKDOPFFZ-OJYZEZLKSA-N
IUPAC Name: ((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-((((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)(dimethylamino)phosphoryl)morpholin-2-yl)methyl dimethylphosphoramidochloridate
InChI: InChI=1S/C57H59ClN14O8P2/c1-67(2)81(58,75)77-34-46-31-70(33-48(80-46)72-39-64-50-52(60-37-62-54(50)72)66-56(74)41-22-12-6-13-23-41)82(76,68(3)4)78-35-45-30-69(57(42-24-14-7-15-25-42,43-26-16-8-17-27-43)44-28-18-9-19-29-44)32-47(79-45)71-38-63-49-51(59-36-61-53(49)71)65-55(73)40-20-10-5-11-21-40/h5-29,36-39,45-48H,30-35H2,1-4H3,(H,59,61,65,73)(H,60,62,66,74)/t45-,46-,47+,48+,81?,82?/m0/s1
Synonyms: DMO-4A(Bz)A(Bz)-N,N-dimethyl phosphoramidochloridate

DMO-4CA-N,N-dimethyl phosphoramidochloridate

Description: DMO-4CA-N,N-dimethyl phosphoramidochloridate is a reagent employed in oligonucleotide synthesis. It contains a 4-amino group on the cytosine nucleobase and a dimethyl phosphoramidochloridate group, allowing for the introduction of specific phosphoramidite functionalities. This enhances the stability and binding properties of the resulting oligonucleotides, making it useful for various research and therapeutic applications.
CAT: BRP-01140
Molecular Formula: C56H59ClN12O9P2
Molecular Weight: 1141.56
Purity: ≥95% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: VVSWCOAQQJYWEF-INJDICEFSA-N
IUPAC Name: ((2S,6R)-6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-((((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)(dimethylamino)phosphoryl)morpholin-2-yl)methyl dimethylphosphoramidochloridate
InChI: InChI=1S/C56H59ClN12O9P2/c1-64(2)79(57,73)75-36-46-33-67(35-49(78-46)68-31-30-47(62-55(68)72)61-53(70)40-20-10-5-11-21-40)80(74,65(3)4)76-37-45-32-66(56(42-24-14-7-15-25-42,43-26-16-8-17-27-43)44-28-18-9-19-29-44)34-48(77-45)69-39-60-50-51(58-38-59-52(50)69)63-54(71)41-22-12-6-13-23-41/h5-31,38-39,45-46,48-49H,32-37H2,1-4H3,(H,58,59,63,71)(H,61,62,70,72)/t45-,46-,48+,49+,79?,80?/m0/s1
Synonyms: DMO-4C(Bz)A(Bz)-N,N-dimethyl phosphoramidochloridate

DMO-4CC-N,N-dimethyl phosphoramidochloridate

Description: DMO-4CC-N,N-dimethyl phosphoramidochloridate is a reagent used in oligonucleotide synthesis, featuring a 4-amino group on the cytosine nucleobase and a dimethyl phosphoramidochloridate group. It enables the introduction of specific phosphoramidite functionalities, enhancing the stability and binding affinity of the synthesized oligonucleotides. This reagent is valuable for research and therapeutic applications in nucleic acid chemistry.
CAT: BRP-01141
Molecular Formula: C55H59ClN10O10P2
Molecular Weight: 1117.52
Purity: ≥95% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: AJXQYLRIFMQLHF-XWKZHAFPSA-N
IUPAC Name: ((2S,6R)-6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-((((2S,6R)-6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methoxy)(dimethylamino)phosphoryl)morpholin-2-yl)methyl dimethylphosphoramidochloridate
InChI: InChI=1S/C55H59ClN10O10P2/c1-61(2)77(56,71)73-38-46-35-64(37-50(76-46)66-33-31-48(60-54(66)70)58-52(68)41-22-12-6-13-23-41)78(72,62(3)4)74-39-45-34-63(36-49(75-45)65-32-30-47(59-53(65)69)57-51(67)40-20-10-5-11-21-40)55(42-24-14-7-15-25-42,43-26-16-8-17-27-43)44-28-18-9-19-29-44/h5-33,45-46,49-50H,34-39H2,1-4H3,(H,57,59,67,69)(H,58,60,68,70)/t45-,46-,49+,50+,77?,78?/m0/s1
Synonyms: DMO-4C(Bz)C(Bz)-N,N-dimethyl phosphoramidochloridate

DMO-4AC-N,N-dimethyl phosphoramidochloridate

Description: DMO-4AC-N,N-dimethyl phosphoramidochloridate is a reagent used in oligonucleotide synthesis. It contains a 4-amino group on the adenine nucleobase and a dimethyl phosphoramidochloridate group, allowing for the introduction of specific phosphoramidite functionalities. This enhances the stability, binding affinity, and overall performance of the resulting oligonucleotides, making it valuable for research and therapeutic applications.
CAT: BRP-01142
Molecular Formula: C56H59ClN12O9P2
Molecular Weight: 1141.56
Purity: ≥95% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: MGRBUUDLZWZYSJ-INJDICEFSA-N
IUPAC Name: ((2S,6R)-4-((((2S,6R)-6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methoxy)(dimethylamino)phosphoryl)-6-(6-benzamido-9H-purin-9-yl)morpholin-2-yl)methyl dimethylphosphoramidochloridate
InChI: InChI=1S/C56H59ClN12O9P2/c1-64(2)79(57,73)75-36-46-33-67(35-49(78-46)69-39-60-50-51(58-38-59-52(50)69)63-54(71)41-22-12-6-13-23-41)80(74,65(3)4)76-37-45-32-66(34-48(77-45)68-31-30-47(62-55(68)72)61-53(70)40-20-10-5-11-21-40)56(42-24-14-7-15-25-42,43-26-16-8-17-27-43)44-28-18-9-19-29-44/h5-31,38-39,45-46,48-49H,32-37H2,1-4H3,(H,58,59,63,71)(H,61,62,70,72)/t45-,46-,48+,49+,79?,80?/m0/s1
Synonyms: DMO-4A(Bz)C(Bz)-N,N-dimethyl phosphoramidochloridate
* Only for research. Not suitable for any diagnostic or therapeutic use.

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