What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

5'-BzH-2'-OMe-Ur-3'-Methoxyphosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside modified with a benzoylhydrazine (BzH) group at the 5'-position, a 2'-O-methyl group, and protected at the 3'-position with a methoxy group. Such modifications are used in RNA research to study RNA-protein interactions, RNA stability, and enzymatic processes.

CAT: BRP-01119

Molecular Formula: C36H58N3O10PSi3

Molecular Weight: 808.09

Purity: ≥97% by HPLC

Appearance: Colorless or faint yellow oily matter

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InChIKey: CDIAPRHBHZFMSI-UZMHDONASA-N

IUPAC Name: (2R,3R,4R,5R)-2-(((3-(benzhydryloxy)-1,1,1,5,5,5-hexamethyltrisiloxan-3-yl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C36H58N3O10PSi3/c1-26(2)39(27(3)4)50(43-6)46-33-30(45-35(34(33)42-5)38-24-23-31(40)37-36(38)41)25-44-53(48-51(7,8)9,49-52(10,11)12)47-32(28-19-15-13-16-20-28)29-21-17-14-18-22-29/h13-24,26-27,30,32-35H,25H2,1-12H3,(H,37,40,41)/t30-,33-,34-,35-,50?/m1/s1

Synonyms: 5'-BzH-2'-O-methyl-Uridine-3'-Methoxyphosphoramidite

5'-BzH-2'-OMe-Ac-Cr-3'-Methoxyphosphoramidite

Description: This phosphoramidite introduces an adenosine nucleoside modified with a benzoylhydrazine (BzH) group at the 5'-position, a 2'-O-methyl group, an acetyl group, and protected at the 3'-position with a methoxy group. Modifications like these are employed in RNA chemical biology to probe RNA structure and function, as well as for therapeutic applications.

CAT: BRP-01120

Molecular Formula: C38H61N4O10PSi3

Molecular Weight: 849.14

Purity: ≥97% by HPLC

Appearance: Colorless or faint yellow oily matter

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InChIKey: UYPJICYBURNHSL-MCXUBDGSSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(((3-(benzhydryloxy)-1,1,1,5,5,5-hexamethyltrisiloxan-3-yl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C38H61N4O10PSi3/c1-27(2)42(28(3)4)53(46-7)49-35-32(48-37(36(35)45-6)41-25-24-33(39-29(5)43)40-38(41)44)26-47-56(51-54(8,9)10,52-55(11,12)13)50-34(30-20-16-14-17-21-30)31-22-18-15-19-23-31/h14-25,27-28,32,34-37H,26H2,1-13H3,(H,39,40,43,44)/t32-,35-,36-,37-,53?/m1/s1

Synonyms: 5'-BzH-2'-O-methyl-Ac-Cytidine-3'-Methoxyphosphoramidite

O4-(p-tolyl pivalate)-5'-DMT-2'-OMe-U Phosphoramidite

Description: This phosphoramidite derivative introduces a uridine nucleoside modified at the O4 position with a p-tolyl pivalate group, protected at the 5'-position with a dimethoxytrityl (DMT) group, and at the 2'-position with a methyl group (2'-O-methyl). This modification can alter RNA structure and stability, influencing interactions with RNA-binding proteins and small molecules.

CAT: BRP-01121

Molecular Formula: C52H63N4O11P

Molecular Weight: 951.05

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: PJMYGKOZFBVJOS-WLKQIKNLSA-N

IUPAC Name: 4-(((1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)oxy)methyl)phenyl pivalate

InChI: InChI=1S/C52H63N4O11P/c1-35(2)56(36(3)4)68(64-32-14-30-53)67-46-44(34-63-52(38-15-12-11-13-16-38,39-19-25-41(59-8)26-20-39)40-21-27-42(60-9)28-22-40)66-48(47(46)61-10)55-31-29-45(54-50(55)58)62-33-37-17-23-43(24-18-37)65-49(57)51(5,6)7/h11-13,15-29,31,35-36,44,46-48H,14,32-34H2,1-10H3/t44-,46-,47-,48-,68?/m1/s1

Synonyms: O4-(p-tolyl pivalate)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine-3'-cyanoethyl Phosphoramidite

Abasic MOE amidite (α,β mix)

Description: This amidite derivative introduces an abasic site mimic using a methoxyethyl (MOE) group, where the α and β anomeric forms are mixed. Abasic modifications are useful in RNA research to study the effects of missing bases on RNA structure and function.

CAT: BRP-01122

Molecular Formula: C44H65N2O9PSi

Molecular Weight: 825.05

Purity: ≥90% by HPLC

Appearance: Clear colorless to yellow oily matter

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InChIKey: OHGFRENWOYSROB-AQJVDKPMSA-N

IUPAC Name: (2R,3R,4R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-((tert-butyldimethylsilyl)oxy)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H65N2O9PSi/c1-32(2)46(33(3)4)56(52-28-16-27-45)54-40-39(53-42(41(40)50-30-29-47-8)55-57(11,12)43(5,6)7)31-51-44(34-17-14-13-15-18-34,35-19-23-37(48-9)24-20-35)36-21-25-38(49-10)26-22-36/h13-15,17-26,32-33,39-42H,16,28-31H2,1-12H3/t39-,40-,41-,42?,56?/m1/s1

Synonyms: Abasic MOE amidite (mixture of alpha and beta)

2,6-diamino(N2,N6-diiBu)-DMT-2'-O-MOE-purine riboside-CE-Phosphoramidite

Description: This phosphoramidite introduces a purine riboside nucleoside modified with 2,6-diamino groups at the N2 and N6 positions, protected with a dimethoxytrityl (DMT) group at the 5'-position, and a methoxyethyl (MOE) group at the 2'-position. Such modifications can enhance RNA binding affinity and stability, useful in RNA structure studies and therapeutic RNA design.

CAT: BRP-01123

Molecular Formula: C51H67N8O10P

Molecular Weight: 983.10

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: NHUMZBQEINRZEF-RTHUGTBQSA-N

CanonicalSMILES: CC(C)C(=O)NC1=C2C(=NC(=N1)NC(=O)C(C)C)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-methoxyethoxy)oxolan-2-yl]-2-(2-methylpropanoylamino)purin-6-yl]-2-methylpropanamide

InChI: InChI=1S/C51H67N8O10P/c1-32(2)47(60)54-45-42-46(56-50(55-45)57-48(61)33(3)4)58(31-53-42)49-44(65-29-28-62-9)43(69-70(67-27-15-26-52)59(34(5)6)35(7)8)41(68-49)30-66-51(36-16-13-12-14-17-36,37-18-22-39(63-10)23-19-37)38-20-24-40(64-11)25-21-38/h12-14,16-25,31-35,41,43-44,49H,15,27-30H2,1-11H3,(H2,54,55,56,57,60,61)/t41-,43-,44-,49-,70?/m1/s1

Synonyms: 2,6-diamino(N2,N6-diisobutyryl)-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-purine riboside-3'-cyanoethyl Phosphoramidite; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,6-diisobutyramido-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-DMT-2'-O-NMA-5-Me-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside modified with a dimethoxytrityl (DMT) group at the 5'-position, a 2'-O-N-methylamino (NMA) group, and a methyl group at the 5-position, protected with a cyanoethyl (CE) group at the 3'-position. This modification can influence RNA structure and function, including RNA-protein interactions and stability.

CAT: BRP-01124

CAS: 1025783-16-7

Molecular Formula: C43H54N5O10P

Molecular Weight: 831.89

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: FYNKMLIMLHVWST-FMMLDEGOSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=O)NC2=O)C)C1OCC(=O)NC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H54N5O10P/c1-28(2)48(29(3)4)59(56-24-12-23-44)58-38-36(57-41(39(38)54-27-37(49)45-6)47-25-30(5)40(50)46-42(47)51)26-55-43(31-13-10-9-11-14-31,32-15-19-34(52-7)20-16-32)33-17-21-35(53-8)22-18-33/h9-11,13-22,25,28-29,36,38-39,41H,12,24,26-27H2,1-8H3,(H,45,49)(H,46,50,51)/t36-,38-,39-,41-,59?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-5-methyluridine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite; 2'-O-NMA 5-Me-U amidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-CE-Phosphoramidite

Description: 5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-CE-Phosphoramidite is a modified adenine nucleoside phosphoramidite used in DNA and RNA synthesis. It features a DMTr (dimethoxytrityl) protecting group at the 5' position, a TMBTM (trimethoxybenzylthiomethyl) group at the 2' position, and a benzoyl-protected adenine base. This compound is essential for the synthesis of oligonucleotides with enhanced stability and functionality for use in genetic research and biotechnology.

CAT: BRP-01125

Molecular Formula: C58H66N7O11PS

Molecular Weight: 1100.24

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: XJUICBHZUQLUOH-WMPDMCAKSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C58H66N7O11PS/c1-38(2)65(39(3)4)77(74-30-16-29-59)76-52-50(33-73-58(41-19-14-11-15-20-41,42-21-25-44(67-5)26-22-42)43-23-27-45(68-6)28-24-43)75-57(53(52)72-37-78-34-47-48(70-8)31-46(69-7)32-49(47)71-9)64-36-62-51-54(60-35-61-55(51)64)63-56(66)40-17-12-10-13-18-40/h10-15,17-28,31-32,35-36,38-39,50,52-53,57H,16,30,33-34,37H2,1-9H3,(H,60,61,63,66)/t50-,52-,53-,57-,77?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-adenosine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-C(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a cytidine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a dimethoxytrityl (DMTr) group at the 5'-position. It is also modified with a benzoyl (Bz) group at the 3'-position and protected with a cyanoethyl (CE) group. Such modifications can enhance RNA stability and specificity in biochemical and therapeutic applications.

CAT: BRP-01126

CAS: 2253978-43-5

Molecular Formula: C57H66N5O12PS

Molecular Weight: 1076.21

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: JILKHWGHHKCHDX-LEGKXAINSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OCSCC=4C(OC)=CC(OC)=CC4OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H66N5O12PS/c1-38(2)62(39(3)4)75(72-32-16-30-58)74-52-50(35-71-57(41-19-14-11-15-20-41,42-21-25-44(65-5)26-22-42)43-23-27-45(66-6)28-24-43)73-55(61-31-29-51(60-56(61)64)59-54(63)40-17-12-10-13-18-40)53(52)70-37-76-36-47-48(68-8)33-46(67-7)34-49(47)69-9/h10-15,17-29,31,33-34,38-39,50,52-53,55H,16,32,35-37H2,1-9H3,(H,59,60,63,64)/t50-,52-,53-,55-,75?/m1/s1

Synonyms: N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-cytidine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-G(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a guanosine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a DMTr group at the 5'-position. It is modified with an isobutyryl (iBu) group at the 3'-position and protected with a CE group. Modifications like these can enhance RNA structure and function, impacting gene expression and regulatory mechanisms.

CAT: BRP-01127

CAS: 2253978-42-4

Molecular Formula: C55H68N7O12PS

Molecular Weight: 1082.22

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: ZUFAHXPFYJOCTP-DRQNSODDSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OCSCC=4C(OC)=CC(OC)=CC4OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H68N7O12PS/c1-34(2)51(63)59-54-58-50-47(52(64)60-54)57-32-61(50)53-49(70-33-76-31-43-44(68-10)28-42(67-9)29-45(43)69-11)48(74-75(72-27-15-26-56)62(35(3)4)36(5)6)46(73-53)30-71-55(37-16-13-12-14-17-37,38-18-22-40(65-7)23-19-38)39-20-24-41(66-8)25-21-39/h12-14,16-25,28-29,32,34-36,46,48-49,53H,15,27,30-31,33H2,1-11H3,(H2,58,59,60,63,64)/t46-,48-,49-,53-,75?/m1/s1

Synonyms: N2-isobutyryl-5'-O-4,4'-(dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-guanosine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a DMTr group at the 5'-position. It is modified with a uracil base at the 3'-position and protected with a CE group. Modifications like these are useful in RNA research to study RNA-protein interactions and enzymatic processes.

CAT: BRP-01128

CAS: 1449578-46-4

Molecular Formula: C50H61N4O12PS

Molecular Weight: 973.09

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: JNQQDMGQFJAHSP-NCVHJKQYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCSCC2=C(C=C(C=C2OC)OC)OC)N3C=CC(=O)NC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-[(2,4,6-trimethoxyphenyl)methylsulfanylmethoxy]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C50H61N4O12PS/c1-33(2)54(34(3)4)67(64-27-13-25-51)66-46-44(30-63-50(35-14-11-10-12-15-35,36-16-20-38(57-5)21-17-36)37-18-22-39(58-6)23-19-37)65-48(53-26-24-45(55)52-49(53)56)47(46)62-32-68-31-41-42(60-8)28-40(59-7)29-43(41)61-9/h10-12,14-24,26,28-29,33-34,44,46-48H,13,27,30-32H2,1-9H3,(H,52,55,56)/t44-,46-,47-,48-,67?/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-uridine-3'-cyanoethyl Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[(2,4,6-trimethoxyphenyl)methyl]thio]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-Trifluoroacetamido propyl-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is protected with a CE group at the 3'-position. Such modifications can alter RNA stability and interactions with other molecules in biochemical studies.

CAT: BRP-01129

CAS: 165381-49-7

Molecular Formula: C44H53F3N5O10P

Molecular Weight: 899.90

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: JDBCEYQBKYYZNE-OVLVZACUSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCCNC(=O)C(F)(F)F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[3-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxypropyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C44H53F3N5O10P/c1-29(2)52(30(3)4)63(60-27-10-23-48)62-38-36(61-40(51-25-22-37(53)50-42(51)55)39(38)58-26-11-24-49-41(54)44(45,46)47)28-59-43(31-12-8-7-9-13-31,32-14-18-34(56-5)19-15-32)33-16-20-35(57-6)21-17-33/h7-9,12-22,25,29-30,36,38-40H,10-11,24,26-28H2,1-6H3,(H,49,54)(H,50,53,55)/t36-,38-,39-,40-,63?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-uridine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[3-[(trifluoroacetyl)amino]propyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-O-Trifluoroacetamido propyl Uridine CED phosphoramidite

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-G(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a guanosine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is modified with an isobutyryl (iBu) group at the 3'-position and protected with a CE group. Modifications like these can enhance RNA binding affinity and stability.

CAT: BRP-01130

Molecular Formula: C49H60F3N8O10P

Molecular Weight: 1009.03

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: HSHKDSSCDQGICM-WYWHGLPISA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCCNC(=O)C(F)(F)F

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[3-[(2,2,2-trifluoroacetyl)amino]propoxy]oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C49H60F3N8O10P/c1-30(2)43(61)57-47-56-42-39(44(62)58-47)55-29-59(42)45-41(66-26-13-25-54-46(63)49(50,51)52)40(70-71(68-27-12-24-53)60(31(3)4)32(5)6)38(69-45)28-67-48(33-14-10-9-11-15-33,34-16-20-36(64-7)21-17-34)35-18-22-37(65-8)23-19-35/h9-11,14-23,29-32,38,40-41,45H,12-13,25-28H2,1-8H3,(H,54,63)(H2,56,57,58,61,62)/t38-,40-,41-,45-,71?/m1/s1

Synonyms: N2-isobutyryl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(3-(2,2,2-trifluoroacetamido)propoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-C(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a cytidine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is modified with a benzoyl (Bz) group at the 3'-position and protected with a CE group. Such modifications can influence RNA structure and function in biochemical and therapeutic applications.

CAT: BRP-01131

CAS: 165381-54-4

Molecular Formula: C51H58F3N6O10P

Molecular Weight: 1003.03

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: PLGRAOCWBZAGHT-YJGWTFTBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCCNC(=O)C(F)(F)F)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[3-[(2,2,2-trifluoroacetyl)amino]propoxy]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C51H58F3N6O10P/c1-34(2)60(35(3)4)71(68-32-13-28-55)70-44-42(33-67-50(37-17-11-8-12-18-37,38-19-23-40(64-5)24-20-38)39-21-25-41(65-6)26-22-39)69-47(45(44)66-31-14-29-56-48(62)51(52,53)54)59-30-27-43(58-49(59)63)57-46(61)36-15-9-7-10-16-36/h7-12,15-27,30,34-35,42,44-45,47H,13-14,29,31-33H2,1-6H3,(H,56,62)(H,57,58,61,63)/t42-,44-,45-,47-,71?/m1/s1

Synonyms: N4-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; N4-Benzoyl-5'-O-DMTr-2'-O-(N3-trifluoroacetyl)cytidine 3'-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[3-[(trifluoroacetyl)amino]propyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-O-Trifluoroacetamido propyl Cytidine CED phosphoramidite

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-A(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces an adenosine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is modified with a benzoyl (Bz) group at the 3'-position and protected with a CE group. Modifications like these are important for RNA research, enabling the study of RNA structure and function in various biological contexts.

CAT: BRP-01132

Molecular Formula: C52H58F3N8O9P

Molecular Weight: 1027.05

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: FDFXBSKFDLJDCP-DTABEXQVSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(3-(2,2,2-trifluoroacetamido)propoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H58F3N8O9P/c1-34(2)63(35(3)4)73(70-30-13-27-56)72-44-42(31-69-51(37-17-11-8-12-18-37,38-19-23-40(66-5)24-20-38)39-21-25-41(67-6)26-22-39)71-49(45(44)68-29-14-28-57-50(65)52(53,54)55)62-33-60-43-46(58-32-59-47(43)62)61-48(64)36-15-9-7-10-16-36/h7-12,15-26,32-35,42,44-45,49H,13-14,28-31H2,1-6H3,(H,57,65)(H,58,59,61,64)/t42-,44-,45-,49-,73?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

5'-O-DMTr-2'-ara-OAc-I-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces an inosine nucleoside where the 2'-hydroxyl group is modified with an arabinose acetyl (ara-OAc) group and protected with a DMTr group at the 5'-position. It is protected with a CE group at the 3'-position. Such modifications are used in RNA synthesis to study RNA modifications and their effects on RNA structure and function.

CAT: BRP-01133

CAS: 1449326-35-5

Molecular Formula: C42H49N6O9P

Molecular Weight: 812.86

Purity: ≥95% by HPLC

Appearance: Colorless to light yellow crystalline or white,off-white to light yellow amorphous dry powder

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InChIKey: LDSVRAQLSNCVSP-OOPWZCSESA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=CNC32)C1OC(=O)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl acetate

InChI: InChI=1S/C42H49N6O9P/c1-27(2)48(28(3)4)58(54-23-11-22-43)57-37-35(56-41(38(37)55-29(5)49)47-26-46-36-39(47)44-25-45-40(36)50)24-53-42(30-12-9-8-10-13-30,31-14-18-33(51-6)19-15-31)32-16-20-34(52-7)21-17-32/h8-10,12-21,25-28,35,37-38,41H,11,23-24H2,1-7H3,(H,44,45,50)/t35-,37-,38+,41-,58?/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-actyl-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; 9-[2-O-Acetyl-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-arabinofuranosyl]-1,9-dihydro-6H-purin-6-one

5'-O-DMTr-2'-ara-OMe-I-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces an inosine nucleoside where the 2'-hydroxyl group is modified with an arabinose methyl (ara-OMe) group and protected with a DMTr group at the 5'-position. It is protected with a CE group at the 3'-position. Modifications like these are utilized in RNA research to investigate RNA modifications and their roles in gene expression and disease mechanisms.

CAT: BRP-01134

Molecular Formula: C41H49N6O8P

Molecular Weight: 784.85

Purity: ≥95% by HPLC

Appearance: Colorless to light yellow crystalline or white,off-white to light yellow amorphous dry powder

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InChIKey: PVFNTYBGWVZMCX-LSYABVRWSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=CNC32)C1OC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H49N6O8P/c1-27(2)47(28(3)4)56(53-23-11-22-42)55-36-34(54-40(37(36)51-7)46-26-45-35-38(46)43-25-44-39(35)48)24-52-41(29-12-9-8-10-13-29,30-14-18-32(49-5)19-15-30)31-16-20-33(50-6)21-17-31/h8-10,12-21,25-28,34,36-37,40H,11,23-24H2,1-7H3,(H,43,44,48)/t34-,36-,37+,40-,56?/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; Arainosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-C(Ac)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-C(Ac)-3'-CE-Phosphoramidite] is a chemically modified nucleoside phosphoramidite used in the synthesis of stable and resistant oligonucleotides. The modifications, including the 2'-O-methyl, phosphorothioate, and various protecting groups, enhance the stability, binding affinity, and resistance to degradation of the resulting oligonucleotides. This makes it a valuable tool in biochemical research and therapeutic development.

CAT: BRP-01135

Molecular Formula: C57H71N9O16P2S

Molecular Weight: 1232.25

Purity: ≥95% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: DZYQPLFPNVDNBI-OERPVMKOSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H71N9O16P2S/c1-36(2)66(37(3)4)83(76-32-14-28-58)81-49-46(80-53(51(49)73-9)64-30-26-47(60-38(5)67)62-55(64)69)35-78-84(85,77-33-15-29-59)82-50-45(79-54(52(50)74-10)65-31-27-48(61-39(6)68)63-56(65)70)34-75-57(40-16-12-11-13-17-40,41-18-22-43(71-7)23-19-41)42-20-24-44(72-8)25-21-42/h11-13,16-27,30-31,36-37,45-46,49-54H,14-15,32-35H2,1-10H3,(H,60,62,67,69)(H,61,63,68,70)/t45-,46-,49-,50-,51-,52-,53-,54-,83?,84?/m1/s1

Synonyms: [5'-O-DMTr-2'-O-Me-C(Ac)](P-thio-pCyEt)[2'-O-Me-C(Ac)-3'-CE-Phosphoramidite

DMO-4AG-N,N-dimethyl phosphoramidochloridate

Description: DMO-4AG-N,N-dimethyl phosphoramidochloridate is a reagent used in oligonucleotide synthesis, featuring a 4-amino group on the nucleobase and a dimethyl phosphoramidochloridate group. This reagent facilitates the introduction of specific phosphoramidite functionalities, enhancing the stability and binding affinity of the synthesized oligonucleotides.

CAT: BRP-01136

Molecular Formula: C62H68ClN15O11P2

Molecular Weight: 1296.72

Purity: ≥98% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: JLONTSADQKXEQI-PIVCNVESSA-N

IUPAC Name: ((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-((dimethylamino)(((2S,6R)-6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)phosphoryl)morpholin-2-yl)methyl dimethylphosphoramidochloridate

InChI: InChI=1S/C62H68ClN15O11P2/c1-42(2)58(79)70-61-69-57-54(60(71-61)85-32-31-43-27-29-48(30-28-43)78(81)82)67-41-77(57)51-35-74(62(45-21-13-8-14-22-45,46-23-15-9-16-24-46)47-25-17-10-18-26-47)33-49(88-51)38-87-91(84,73(5)6)75-34-50(37-86-90(63,83)72(3)4)89-52(36-75)76-40-66-53-55(64-39-65-56(53)76)68-59(80)44-19-11-7-12-20-44/h7-30,39-42,49-52H,31-38H2,1-6H3,(H,64,65,68,80)(H,69,70,71,79)/t49-,50-,51+,52+,90?,91?/m0/s1

Synonyms: DMO-4AG-N,N-dimethyl phosphoramidochloridate

[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. The modifications, including 2'-O-methyl, phosphorothioate, and protective groups like DMTr, acetyl, and isobutyryl, enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic development.

CAT: BRP-01137

Molecular Formula: C60H75N11O16P2S

Molecular Weight: 1300.33

Purity: ≥95% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: WVXVWJZTQGZYKP-AITXLTLESA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C60H75N11O16P2S/c1-36(2)54(73)67-58-66-53-48(55(74)68-58)63-35-70(53)57-51(78-10)49(86-88(81-31-15-28-61)71(37(3)4)38(5)6)46(85-57)34-83-89(90,82-32-16-29-62)87-50-45(84-56(52(50)79-11)69-30-27-47(64-39(7)72)65-59(69)75)33-80-60(40-17-13-12-14-18-40,41-19-23-43(76-8)24-20-41)42-21-25-44(77-9)26-22-42/h12-14,17-27,30,35-38,45-46,49-52,56-57H,15-16,31-34H2,1-11H3,(H,64,65,72,75)(H2,66,67,68,73,74)/t45-,46-,49-,50-,51-,52-,56-,57-,88?,89?/m1/s1

Synonyms: [5'-O-DMTr-2'-O-Me-C(Ac)](P-thio-pCyEt)[2'-O-Me-G(iBu)-3'-CE-Phosphoramidite

[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a chemically modified nucleoside phosphoramidite used in the synthesis of oligonucleotides. The modifications, including 2'-O-methyl, phosphorothioate, and various protecting groups like DMTr and acetyl, enhance the stability, binding affinity, and resistance to degradation of the resulting oligonucleotides. This makes it a valuable tool for biochemical research and therapeutic development.

CAT: BRP-01138

Molecular Formula: C55H68N8O16P2S

Molecular Weight: 1191.20

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: SPDNYGNFSNICHW-SZYQAGCUSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H68N8O16P2S/c1-35(2)63(36(3)4)80(73-31-13-27-56)78-47-44(77-51(49(47)70-8)62-30-26-46(65)60-54(62)67)34-75-81(82,74-32-14-28-57)79-48-43(76-52(50(48)71-9)61-29-25-45(58-37(5)64)59-53(61)66)33-72-55(38-15-11-10-12-16-38,39-17-21-41(68-6)22-18-39)40-19-23-42(69-7)24-20-40/h10-12,15-26,29-30,35-36,43-44,47-52H,13-14,31-34H2,1-9H3,(H,60,65,67)(H,58,59,64,66)/t43-,44-,47-,48-,49-,50-,51-,52-,80?,81?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-C(acetyl)](P-thio-pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]