What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

3'-O-propargyl Uridine CED phosphoramidite

Description: 3'-O-Propargyl Uridine CED phosphoramidite is a modified uridine nucleotide used in the synthesis of oligonucleotides. It features a propargyl group at the 3' position and a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is employed to create functionalized and stable RNA and DNA sequences, supporting advanced research in genetics and molecular biology.

CAT: BRP-01294

Molecular Formula: C42H49N4O9P

Molecular Weight: 784.83

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InChIKey: ORUGVUBQAYTXET-CYSIDSPMSA-N

IUPAC Name: (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H49N4O9P/c1-8-26-51-38-36(54-40(45-25-23-37(47)44-41(45)48)39(38)55-56(53-27-12-24-43)46(29(2)3)30(4)5)28-52-42(31-13-10-9-11-14-31,32-15-19-34(49-6)20-16-32)33-17-21-35(50-7)22-18-33/h1,9-11,13-23,25,29-30,36,38-40H,12,26-28H2,2-7H3,(H,44,47,48)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-propargyl-U-2'-CE-Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-2-propyn-1-yl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

3'-O-propargyl Adenosine (n-bz) CED phosphoramidite

Description: 3'-O-Propargyl Adenosine (n-bz) CED phosphoramidite is a modified adenosine nucleotide used in the synthesis of oligonucleotides. It features a propargyl group at the 3' position and a benzoyl-protected adenine base, along with a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is essential for creating functionalized and stable DNA and RNA sequences, facilitating advanced research in genetics and molecular biology.

CAT: BRP-01299

Molecular Formula: C50H54N7O8P

Molecular Weight: 911.98

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InChIKey: BUDCBFCJBVGQQL-XOMUZYEBSA-N

IUPAC Name: (2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H54N7O8P/c1-8-29-61-44-42(31-62-50(37-18-13-10-14-19-37,38-20-24-40(59-6)25-21-38)39-22-26-41(60-7)27-23-39)64-49(45(44)65-66(63-30-15-28-51)57(34(2)3)35(4)5)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-16-11-9-12-17-36/h1,9-14,16-27,32-35,42,44-45,49H,15,29-31H2,2-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,66?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-propargyl-A(Bz)-2'-CE-Phosphoramidite

3'-O-propargyl Cytidine (n-bz) CED phosphoramidite

Description: 3'-O-Propargyl Cytidine (n-bz) CED phosphoramidite is a modified cytidine nucleotide used in oligonucleotide synthesis. It features a propargyl group at the 3' position and a benzoyl-protected cytosine base, along with a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is utilized for creating functionalized and stable DNA and RNA sequences, supporting advanced genetic and molecular biology research.

CAT: BRP-01300

CAS: 1451256-03-3

Molecular Formula: C49H54N5O9P

Molecular Weight: 887.96

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InChIKey: JCADSQYVEOSYEC-LORUJQNASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OCC#C

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C49H54N5O9P/c1-8-31-59-44-42(33-60-49(37-18-13-10-14-19-37,38-20-24-40(57-6)25-21-38)39-22-26-41(58-7)27-23-39)62-47(45(44)63-64(61-32-15-29-50)54(34(2)3)35(4)5)53-30-28-43(52-48(53)56)51-46(55)36-16-11-9-12-17-36/h1,9-14,16-28,30,34-35,42,44-45,47H,15,31-33H2,2-7H3,(H,51,52,55,56)/t42-,44-,45-,47-,64?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-propargyl-C(Bz)-2'-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-2-propyn-1-yl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

3'-O-propargyl Guanosine (n-ibu) CED phosphoramidite

Description: 3'-O-Propargyl Guanosine (n-ibu) CED phosphoramidite is a modified guanosine nucleotide used in oligonucleotide synthesis. It features a propargyl group at the 3' position and an isobutyryl-protected guanine base, along with a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is essential for creating functionalized and stable DNA and RNA sequences, facilitating advanced research in genetics and molecular biology.

CAT: BRP-01301

Molecular Formula: C47H56N7O9P

Molecular Weight: 893.96

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InChIKey: SDXBQKBJGQGUGW-VCGWOZLGSA-N

IUPAC Name: (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H56N7O9P/c1-10-26-59-40-38(28-60-47(33-15-12-11-13-16-33,34-17-21-36(57-8)22-18-34)35-19-23-37(58-9)24-20-35)62-45(41(40)63-64(61-27-14-25-48)54(31(4)5)32(6)7)53-29-49-39-42(53)50-46(52-44(39)56)51-43(55)30(2)3/h1,11-13,15-24,29-32,38,40-41,45H,14,26-28H2,2-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,64?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-propargyl-G(iBu)-2'-CE-Phosphoramidite

N4-Ethyl Cytidine CED phosphoramidite

Description: N4-Ethyl Cytidine CED phosphoramidite is a chemical compound used in the synthesis of nucleic acids, particularly RNA molecules. It consists of a cytidine nucleoside modified with a tert-butyldimethylsilyl (TBDMS) group at the 2' position and an ethyl group at the N4 position. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified cytidine into the growing RNA chain during solid-phase synthesis, enabling researchers to tailor RNA molecules with specific functionalities for various biological and therapeutic applications.

CAT: BRP-01303

Molecular Formula: C47H66N5O8PSi

Molecular Weight: 888.12

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InChIKey: YLWRTGHURVFSCS-UODQAQMXSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-(ethylamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H66N5O8PSi/c1-13-49-41-28-30-51(45(53)50-41)44-43(60-62(11,12)46(6,7)8)42(59-61(57-31-17-29-48)52(33(2)3)34(4)5)40(58-44)32-56-47(35-18-15-14-16-19-35,36-20-24-38(54-9)25-21-36)37-22-26-39(55-10)27-23-37/h14-16,18-28,30,33-34,40,42-44H,13,17,31-32H2,1-12H3,(H,49,50,53)/t40-,42-,43-,44-,61?/m1/s1

Synonyms: 2'-TBDMS Cytidine(ethyl) 3'-CE-phosphoramidite; N4-Ethyl Cytidine 3'-tBDSilyl CED phosphoramidite; N4-Ethyl Cytidine 2'-tBDSilyl CED phosphoramidite

4-Thio Uridine CED phosphoramidite

Description: 4-Thio Uridine CED phosphoramidite is a compound used in the chemical synthesis of nucleic acids, particularly RNA molecules. It consists of a uridine nucleoside modified with a 2'-TBDMS (tert-butyldimethylsilyl) group at the 2' position and a 4-S-(2-cyanoethyl) modification. Additionally, it contains a CE (2-cyanoethyl) phosphoramidite moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified uridine into the growing RNA chain during solid-phase synthesis, enabling researchers to tailor RNA molecules with specific functionalities for various biological and therapeutic applications.

CAT: BRP-01305

CAS: 154665-04-0

Molecular Formula: C48H64N5O8PSSi

Molecular Weight: 930.18

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InChIKey: DKQKZAVAXOCNNU-CRHOWCKESA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=NC2=O)SCCC#N)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-[4-(2-cyanoethylsulfanyl)-2-oxopyrimidin-1-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C48H64N5O8PSSi/c1-34(2)53(35(3)4)62(58-31-15-28-49)60-43-41(59-45(44(43)61-64(10,11)47(5,6)7)52-30-27-42(51-46(52)54)63-32-16-29-50)33-57-48(36-17-13-12-14-18-36,37-19-23-39(55-8)24-20-37)38-21-25-40(56-9)26-22-38/h12-14,17-27,30,34-35,41,43-45H,15-16,31-33H2,1-11H3/t41-,43-,44-,45-,62?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-4-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-4-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 4-S-(2-cyanoethyl)-2'-TBDMS-U 3'-CE-phosphoramidite

MMT-2'-tBDSilyl Adenosine (n-bz) CED phosphoramidite

Description: MMT-2'-tBDSilyl Adenosine (n-bz) CED phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It comprises an adenosine nucleoside modified with a 2'-tBDSilyl group and protected with a benzoyl (n-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. The MMT (Monomethoxytrityl) group is typically used for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative enables efficient and selective incorporation of the modified adenosine into the growing nucleotide chain during solid-phase synthesis. It plays a crucial role in the design and synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01320

CAS: 135711-69-2

Molecular Formula: C52H64N7O7PSi

Molecular Weight: 958.17

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InChIKey: VMFYLWGANHVWAU-LTMMGAFGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C52H64N7O7PSi/c1-36(2)59(37(3)4)67(63-32-20-31-53)65-45-43(33-62-52(39-23-16-12-17-24-39,40-25-18-13-19-26-40)41-27-29-42(61-8)30-28-41)64-50(46(45)66-68(9,10)51(5,6)7)58-35-56-44-47(54-34-55-48(44)58)57-49(60)38-21-14-11-15-22-38/h11-19,21-30,34-37,43,45-46,50H,20,32-33H2,1-10H3,(H,54,55,57,60)/t43-,45-,46-,50-,67?/m1/s1

Synonyms: 5'-MMT-2'-TBDMS A(Bz) 3'-CE phosphoramidite; Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

MMT-2'-tBDSilyl Guanosine (n-ibu) CED phosphoramidite

Description: MMT-2'-tBDSilyl Guanosine (n-ibu) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-tBDSilyl group and protected with an isobutyryl (n-ibu) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which acts as a protecting group during the synthesis process. The MMT (Monomethoxytrityl) group is typically employed for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative facilitates efficient and selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. It is essential for designing and synthesizing modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01321

Molecular Formula: C49H66N7O8PSi

Molecular Weight: 940.15

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InChIKey: XJHPFJYSMMSOCC-VKFKYRIUSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H66N7O8PSi/c1-32(2)44(57)53-47-52-43-40(45(58)54-47)51-31-55(43)46-42(64-66(11,12)48(7,8)9)41(63-65(61-29-19-28-50)56(33(3)4)34(5)6)39(62-46)30-60-49(35-20-15-13-16-21-35,36-22-17-14-18-23-36)37-24-26-38(59-10)27-25-37/h13-18,20-27,31-34,39,41-42,46H,19,29-30H2,1-12H3,(H2,52,53,54,57,58)/t39-,41-,42-,46-,65?/m1/s1

Synonyms: 5'-MMT-2'-TBDMS G(iBu) 3'-CE phosphoramidite

MMT-2'-tBDSilyl Guanosine (n-PAC) CED phosphoramidite

Description: MMT-2'-tBDSilyl Guanosine (n-PAC) CED phosphoramidite is used in oligonucleotide synthesis. It comprises a guanosine nucleoside modified with a 2'-tBDSilyl group and protected with a PAC (phenoxyacetyl) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, serving as a protecting group during synthesis. The MMT (Monomethoxytrityl) group temporarily shields hydroxyl groups in nucleosides. This phosphoramidite derivative facilitates efficient and selective incorporation of the modified guanosine into oligonucleotide sequences during solid-phase synthesis, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01322

Molecular Formula: C53H66N7O9PSi

Molecular Weight: 1004.19

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InChIKey: MBHPUJWVPHGMKR-NTWXHQQMSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-(6-oxo-2-(2-phenoxyacetamido)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H66N7O9PSi/c1-36(2)60(37(3)4)70(66-32-20-31-54)68-46-43(33-65-53(38-21-14-11-15-22-38,39-23-16-12-17-24-39)40-27-29-41(63-8)30-28-40)67-50(47(46)69-71(9,10)52(5,6)7)59-35-55-45-48(59)57-51(58-49(45)62)56-44(61)34-64-42-25-18-13-19-26-42/h11-19,21-30,35-37,43,46-47,50H,20,32-34H2,1-10H3,(H2,56,57,58,61,62)/t43-,46-,47-,50-,70?/m1/s1

Synonyms: 5'-MMT-2'-TBDMS G(Pac) 3'-CE phosphoramidite

MMT-2'-tBDSilyl Adenosine (n-PAC) CED phosphoramidite

Description: MMT-2'-tBDSilyl Adenosine (n-PAC) CED phosphoramidite is utilized in oligonucleotide synthesis. It involves an adenosine nucleoside modified with a 2'-tBDSilyl group and protected with a PAC (phenoxyacetyl) group, coupled with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. The MMT (Monomethoxytrityl) group is typically used for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative enables efficient and selective incorporation of the modified adenosine into oligonucleotide sequences during solid-phase synthesis, essential for customized oligonucleotide design in various biological applications.

CAT: BRP-01323

Molecular Formula: C53H66N7O8PSi

Molecular Weight: 988.19

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InChIKey: HVOWVANSACUJFY-RPWAFYAOSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H66N7O8PSi/c1-37(2)60(38(3)4)69(65-32-20-31-54)67-47-44(33-64-53(39-21-14-11-15-22-39,40-23-16-12-17-24-40)41-27-29-42(62-8)30-28-41)66-51(48(47)68-70(9,10)52(5,6)7)59-36-57-46-49(55-35-56-50(46)59)58-45(61)34-63-43-25-18-13-19-26-43/h11-19,21-30,35-38,44,47-48,51H,20,32-34H2,1-10H3,(H,55,56,58,61)/t44-,47-,48-,51-,69?/m1/s1

Synonyms: 5'-MMT-2'-TBDMS A(Pac) 3'-CE phosphoramidite

N2-Isobutyryl-2'-tert-butyldimethylsilyl-7-deaza-5'-O-DMT-guanosine 3'-CE phosphoramidite

Description: N2-Isobutyryl-2'-tert-butyldimethylsilyl-7-deaza-5'-O-DMT-guanosine 3'-CE phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified at the N2 position with an isobutyryl group, at the 2' position with a tert-butyldimethylsilyl group, and at the 5' position with a DMT (dimethoxytrityl) group. Additionally, it contains a CE (2-cyanoethyl) phosphoramidite moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative enables the efficient and selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. It is crucial in the design and synthesis of modified oligonucleotides for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01326

CAS: 1220889-83-7

Molecular Formula: C51H69N6O9PSi

Molecular Weight: 969.19

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InChIKey: ONYAZCDFEDIGRJ-DGMLWHETSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H69N6O9PSi/c1-33(2)46(58)54-49-53-45-41(47(59)55-49)28-30-56(45)48-44(66-68(12,13)50(7,8)9)43(65-67(63-31-17-29-52)57(34(3)4)35(5)6)42(64-48)32-62-51(36-18-15-14-16-19-36,37-20-24-39(60-10)25-21-37)38-22-26-40(61-11)27-23-38/h14-16,18-28,30,33-35,42-44,48H,17,31-32H2,1-13H3,(H2,53,54,55,58,59)/t42-,43-,44-,48-,67?/m1/s1

Synonyms: N-[7-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2-methylpropanamide; 7-Deaza Guanosine CED phosphoramidite; 7-Deaza 2'-TDDMS Guanosine(iBu) 3'-CE phosphoramidite

8-Oxo-5'-DMT-2'-TBDMS Guanosine(iBu) 3'-CE Phosphoramidite

Description: 8-Oxo-2'-tBDSilyl Guanosine CED Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It comprises a guanosine nucleoside modified with an 8-oxo group at the 8-position of the purine ring, protected with a TBDMS (tert-butyldimethylsilyl) group at the 2'-position, and with an isobutyryl (n-iBu) group. Additionally, it contains a phosphoramidite moiety with a CE (cyanoethyl) group, serving as a protecting group during synthesis. This phosphoramidite derivative enables precise and efficient incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. The presence of the 8-oxo modification is significant for investigating oxidative stress, DNA damage, and RNA modification processes.

CAT: BRP-01327

Molecular Formula: C49H67N8O9PSi

Molecular Weight: 971.16

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InChIKey: OUWOXJVBKDMSKC-NHXVREKOSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((dimethylamino)methylene)amino)-6,8-dioxo-1,6,7,8-tetrahydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H67N8O9PSi/c1-32(2)57(33(3)4)67(63-29-17-28-50)65-41-39(30-62-49(34-18-15-14-16-19-34,35-20-24-37(60-10)25-21-35)36-22-26-38(61-11)27-23-36)64-45(42(41)66-68(12,13)48(5,6)7)56-43-40(52-47(56)59)44(58)54-46(53-43)51-31-55(8)9/h14-16,18-27,31-33,39,41-42,45H,17,29-30H2,1-13H3,(H,52,59)(H,53,54,58)/t39-,41-,42-,45-,67?/m1/s1

Synonyms: 8-Oxo-2'-tBDSilyl Guanosine CED Phosphoramidite

Fmoc-Amino-DMT C-3 CED phosphoramidite

Description: Fmoc-Amino-DMT C-3 CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It features an Fmoc-protected amino group, a DMT group for 5' hydroxyl protection, and a C-3 spacer linked to a cyanoethyl diisopropyl (CED) phosphoramidite group. This compound enables the controlled addition of amino functionalities to oligonucleotides, facilitating further chemical modifications or conjugations for various research and diagnostic applications.

CAT: BRP-01334

CAS: 146918-92-5

Molecular Formula: C48H54N3O7P

Molecular Weight: 815.93

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InChIKey: JGNRMZONTWRREU-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(COC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)CNC(=O)OCC4C=5C=CC=CC5C=6C=CC=CC64)N(C(C)C)C(C)C

IUPAC Name: (9H-fluoren-9-yl)methyl (3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propyl)carbamate

InChI: InChI=1S/C48H54N3O7P/c1-34(2)51(35(3)4)59(57-30-14-29-49)58-41(31-50-47(52)55-33-46-44-19-12-10-17-42(44)43-18-11-13-20-45(43)46)32-56-48(36-15-8-7-9-16-36,37-21-25-39(53-5)26-22-37)38-23-27-40(54-6)28-24-38/h7-13,15-28,34-35,41,46H,14,30-33H2,1-6H3,(H,50,52)

Synonyms: 5-Oxa-2,7-diaza-6-phosphanonanoic acid, 4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-(2-cyanoethoxy)-8-methyl-7-(1-methylethyl)-, 9H-fluoren-9-ylmethyl ester; 5,7-Dioxa-2-aza-6-phosphanonanoic acid, 4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[bis(1-methylethyl)amino]-9-cyano-, 9H-fluoren-9-ylmethyl ester; 9H-Fluoren-9-ylmethyl 4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-(2-cyanoethoxy)-8-methyl-7-(1-methylethyl)-5-oxa-2,7-diaza-6-phosphanonanoate

TFA-Amino C-4 CED phosphoramidite

Description: TFA-Amino C-4 CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It contains a trifluoroacetyl (TFA)-protected amino group, a C-4 spacer, and a cyanoethyl diisopropyl (CED) phosphoramidite group. This compound facilitates controlled addition of amino functionalities to oligonucleotides, enabling further chemical modifications or conjugations for various research and diagnostic applications.

CAT: BRP-01335

CAS: 936471-68-0

Molecular Formula: C15H27F3N3O3P

Molecular Weight: 385.26

Purity: ≥97%

Appearance: Colourless oily matter

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Storage: Store at -20 °C

InChIKey: XYETVXUHNJIELA-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCNC(=O)C(F)(F)F)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (4-(2,2,2-trifluoroacetamido)butyl) diisopropylphosphoramidite

InChI: InChI=1S/C15H27F3N3O3P/c1-12(2)21(13(3)4)25(24-11-7-8-19)23-10-6-5-9-20-14(22)15(16,17)18/h12-13H,5-7,9-11H2,1-4H3,(H,20,22)

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 4-[(2,2,2-trifluoroacetyl)amino]butyl ester; 2-Cyanoethyl 4-[(2,2,2-trifluoroacetyl)amino]butyl N,N-bis(1-methylethyl)phosphoramidite; 5'-Amino-Modifier C4-TFA Phosphoramidite

Fmoc-Amino C-6 3'-CE phosphoramidite

Description: Fmoc-Amino C-6 3'-CE phosphoramidite is a compound used in oligonucleotide synthesis. It features an Fmoc-protected amino group, attached to a C-6 spacer, and a 3'-cyanoethyl (3'-CE) phosphoramidite group. This compound enables the controlled addition of amino functionalities to oligonucleotides, allowing for further chemical modifications or conjugations for various research and diagnostic applications.

CAT: BRP-01336

CAS: 164394-19-8

Molecular Formula: C30H42N3O4P

Molecular Weight: 539.65

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InChIKey: HQKPKYLTHNVWSP-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCNC(=O)OCC1C=2C=CC=CC2C=3C=CC=CC31)N(C(C)C)C(C)C

IUPAC Name: (9H-fluoren-9-yl)methyl (6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamate

InChI: InChI=1S/C30H42N3O4P/c1-23(2)33(24(3)4)38(37-21-13-18-31)36-20-12-6-5-11-19-32-30(34)35-22-29-27-16-9-7-14-25(27)26-15-8-10-17-28(26)29/h7-10,14-17,23-24,29H,5-6,11-13,19-22H2,1-4H3,(H,32,34)

Synonyms: 9-Oxa-2,11-diaza-10-phosphatridecanoic acid, 10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-, 9H-fluoren-9-ylmethyl ester; 9,11-Dioxa-2-aza-10-phosphatridecanoic acid, 10-[bis(1-methylethyl)amino]-13-cyano-, 9H-fluoren-9-ylmethyl ester; 9H-Fluoren-9-ylmethyl 10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-9-oxa-2,11-diaza-10-phosphatridecanoate

Fmoc-Amino-DMT C-7 CE phosphoramidite

Description: Fmoc-Amino-DMT C-7 CE phosphoramidite is a specialized compound utilized in oligonucleotide synthesis. It contains an Fmoc-protected amino group, a DMT group for 5' hydroxyl protection, and a C-7 spacer linked to a cyanoethyl (CE) phosphoramidite group. This compound enables controlled addition of amino functionalities to oligonucleotides, allowing for further chemical modifications or conjugations for various research and diagnostic applications.

CAT: BRP-01337

CAS: 2166602-99-7

Molecular Formula: C51H60N3O8P

Molecular Weight: 874.01

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InChIKey: AHZOYMSGLQGXPM-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(COCCCNC(=O)OCC1C=2C=CC=CC2C=3C=CC=CC31)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (9H-fluoren-9-yl)methyl (3-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propoxy)propyl)carbamate

InChI: InChI=1S/C51H60N3O8P/c1-37(2)54(38(3)4)63(61-33-14-30-52)62-44(34-58-32-15-31-53-50(55)59-36-49-47-20-12-10-18-45(47)46-19-11-13-21-48(46)49)35-60-51(39-16-8-7-9-17-39,40-22-26-42(56-5)27-23-40)41-24-28-43(57-6)29-25-41/h7-13,16-29,37-38,44,49H,14-15,31-36H2,1-6H3,(H,53,55)

Synonyms: 6,9-Dioxa-2,11-diaza-10-phosphatridecanoic acid, 8-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-, 9H-fluoren-9-ylmethyl ester; 9H-Fluoren-9-ylmethyl 8-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-6,9-dioxa-2,11-diaza-10-phosphatridecanoate

2,2'-Anhydro Uridine CED phosphoramidite

Description: 2,2'-Anhydro Uridine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. This modification is attached to a phosphoramidite moiety with a cyanoethyl diisopropyl (CED) group, facilitating its incorporation into the growing oligonucleotide chain during solid-phase synthesis. This reagent enables the introduction of the 2,2'-anhydro uridine modification into synthetic oligonucleotides, allowing for the investigation of its effects on RNA structure and function.

CAT: BRP-01343

Molecular Formula: C39H45N4O8P

Molecular Weight: 728.77

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InChIKey: ZVSMFQYSVMROKY-SGXIJWRWSA-N

IUPAC Name: (2R,3R,3aS,9aR)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-oxo-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C39H45N4O8P/c1-26(2)43(27(3)4)52(48-24-10-22-40)51-35-33(49-37-36(35)50-38-41-34(44)21-23-42(37)38)25-47-39(28-11-8-7-9-12-28,29-13-17-31(45-5)18-14-29)30-15-19-32(46-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3/t33-,35-,36-,37-,52?/m1/s1

Synonyms: 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidine, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]-2,3,3a,9a-tetrahydro-6-oxo-, (2R,3R,3aS,9aR)-

Asymmetrical branching CED phosphoramidite

Description: Asymmetrical branching CED phosphoramidite is a chemical used to introduce branches into oligonucleotides during synthesis. It features an asymmetrical structure that enables the formation of complex, branched DNA or RNA sequences. This reagent is utilized in advanced molecular biology applications, such as the creation of multivalent probes, enhanced signal amplification assays, and the study of complex nucleic acid interactions.

CAT: BRP-01349

CAS: 345663-34-5

Molecular Formula: C38H49N2O8P

Molecular Weight: 692.78

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InChIKey: HYEDNLHCXFQSQY-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(COC(=O)CCC(=O)C)COC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propyl 4-oxopentanoate

InChI: InChI=1S/C38H49N2O8P/c1-28(2)40(29(3)4)49(47-25-11-24-39)48-36(26-45-37(42)23-14-30(5)41)27-46-38(31-12-9-8-10-13-31,32-15-19-34(43-6)20-16-32)33-17-21-35(44-7)22-18-33/h8-10,12-13,15-22,28-29,36H,11,14,23,25-27H2,1-7H3

Synonyms: Pentanoic acid, 4-oxo-, 3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]propyl ester; 3-[Bis(4-methoxyphenyl)phenylmethoxy]-2-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]propyl 4-oxopentanoate

4-Triazolyl 2'-TBDMS Uridine CED phosphoramidite

Description: 4-Triazolyl Uridine CED phosphoramidite is a phosphoramidite derivative of uridine, featuring a 4-triazolyl modification at the 4-position and a tert-butyldimethylsilyl (TBDMS) protection group at the 2'-position. It is utilized in solid-phase oligonucleotide synthesis to introduce the 4-triazolyl modification, enabling the formation of triazole-linked nucleic acids. These modified nucleic acids can be used in various applications, including click chemistry-based conjugation strategies and the study of nucleic acid structure and function.

CAT: BRP-01356

CAS: 3033741-07-7

Molecular Formula: C47H62N7O8PSi

Molecular Weight: 912.10

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InChIKey: SDOHATSBOOYVAE-HEOXLOLOSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)N3N=CN=C3)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxo-4-(1H-1,2,4-triazol-1-yl)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H62N7O8PSi/c1-33(2)54(34(3)4)63(59-29-15-27-48)61-42-40(60-44(43(42)62-64(10,11)46(5,6)7)52-28-26-41(51-45(52)55)53-32-49-31-50-53)30-58-47(35-16-13-12-14-17-35,36-18-22-38(56-8)23-19-36)37-20-24-39(57-9)25-21-37/h12-14,16-26,28,31-34,40,42-44H,15,29-30H2,1-11H3/t40-,42-,43-,44-,63?/m1/s1

Synonyms: 2(1H)-Pyrimidinone, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-4-(1H-1,2,4-triazol-1-yl)-; 4-Triazolyl Uridine CED phosphoramidite

Dabcyl CED phosphoramidite

Description: Dabcyl CED phosphoramidite is a phosphoramidite derivative used for introducing the Dabcyl moiety into oligonucleotide sequences during solid-phase synthesis. Dabcyl is a quencher molecule often employed in the design of molecular probes and assays, particularly for fluorescence-based detection methods. Its ability to quench fluorescence by energy transfer makes it useful for labeling nucleic acids and peptides for various biochemical and molecular biology applications, including fluorescence resonance energy transfer (FRET) assays, nucleic acid hybridization studies, and real-time PCR probes.

CAT: BRP-01357

CAS: 2128327-84-2

Molecular Formula: C51H63N6O7P

Molecular Weight: 903.06

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InChIKey: CFNGUZAXHBVWBU-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(COCCCNC(=O)C1=CC=C(N=NC2=CC=C(C=C2)N(C)C)C=C1)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(3-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)propoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H63N6O7P/c1-38(2)57(39(3)4)65(63-35-12-32-52)64-49(36-61-34-13-33-53-50(58)40-16-22-44(23-17-40)54-55-45-24-26-46(27-25-45)56(5)6)37-62-51(41-14-10-9-11-15-41,42-18-28-47(59-7)29-19-42)43-20-30-48(60-8)31-21-43/h9-11,14-31,38-39,49H,12-13,33-37H2,1-8H3,(H,53,58)