Phosphoramidites

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-methoxy-phosphoramidite

Description: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-Methoxy-phosphoramidite is a phosphoramidite reagent used in the synthesis of modified oligonucleotides. It is used in the development of modified oligonucleotides for therapeutic applications like antisense oligonucleotides and siRNAs, as well as in studies involving nucleic acid interactions, gene silencing, and RNA-based therapies.

CAT: BRP-01552

Molecular Formula: C42H52FN6O8P

Molecular Weight: 818.88

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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InChIKey: WEPASXLNAQHNEK-NNYLMNAYSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C42H52FN6O8P/c1-25(2)38(50)46-41-45-37-35(39(51)47-41)44-24-48(37)40-34(43)36(57-58(54-9)49(26(3)4)27(5)6)33(56-40)23-55-42(28-13-11-10-12-14-28,29-15-19-31(52-7)20-16-29)30-17-21-32(53-8)22-18-30/h10-22,24-27,33-34,36,40H,23H2,1-9H3,(H2,45,46,47,50,51)/t33-,34-,36-,40-,58?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dG(iBu)-3'-Methoxy-phosphoramidite; 2'-F dG(iBu) OMe-amidite; 2'-F Guanosine (n-ibu) Methoxy phosphoramidite

N6-Bz-5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methoxy-phosphoramidite

Description: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methoxy-phosphoramidite is a specialized phosphoramidite reagent utilized in the synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group on the 5' hydroxyl group of the sugar, a 2'-fluoro modification on the deoxyribose sugar of adenine, with a benzoyl (Bz) group at the N6 position of the adenine base, and a 3'-methoxy-phosphoramidite functional group necessary for solid-phase oligonucleotide synthesis. It is valuable in developing oligonucleotides for various applications, including gene silencing (e.g., siRNAs) and therapeutic antisense oligonucleotides. Additionally, it facilitates research into nucleic acid structure, function, and interactions.

CAT: BRP-01553

Molecular Formula: C45H50FN6O7P

Molecular Weight: 836.90

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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InChIKey: NLZONZKTSFBIDR-AGYRQEKTSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C45H50FN6O7P/c1-29(2)52(30(3)4)60(56-7)59-40-37(58-44(38(40)46)51-28-49-39-41(47-27-48-42(39)51)50-43(53)31-14-10-8-11-15-31)26-57-45(32-16-12-9-13-17-32,33-18-22-35(54-5)23-19-33)34-20-24-36(55-6)25-21-34/h8-25,27-30,37-38,40,44H,26H2,1-7H3,(H,47,48,50,53)/t37-,38-,40-,44-,60?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dA(Bz)-3'-Methoxy-phosphoramidite; 2'-F dA(Bz) OMe-amidite; 2'-F adenosine (N-Bz) Methoxy phosphoramidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-methoxy-phosphoramidite

Description: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-methoxy-phosphoramidite is a specialized phosphoramidite reagent used in the synthesis of modified oligonucleotides. This compound includes a 5'-dimethoxytrityl (DMTr) protecting group on the 5' hydroxyl group of the sugar, a 2'-fluoro modification on the deoxyribose sugar of cytosine, and an acetyl (Ac) group attached to the N4 position of the cytosine base. Additionally, it incorporates a 3'-methoxy-phosphoramidite functional group essential for solid-phase oligonucleotide synthesis. It is valuable in developing oligonucleotides for various applications, including gene expression modulation and antisense therapy. Furthermore, it supports studies exploring nucleic acid structure, function, and interactions.

CAT: BRP-01554

CAS: 1001648-84-5

Molecular Formula: C39H48FN4O8P

Molecular Weight: 750.81

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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InChIKey: IGCQRQIRQVZPMT-DJTPZYMWSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2F)NC(=O)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C39H48FN4O8P/c1-25(2)44(26(3)4)53(49-8)52-36-33(51-37(35(36)40)43-23-22-34(41-27(5)45)42-38(43)46)24-50-39(28-12-10-9-11-13-28,29-14-18-31(47-6)19-15-29)30-16-20-32(48-7)21-17-30/h9-23,25-26,33,35-37H,24H2,1-8H3,(H,41,42,45,46)/t33-,35-,36-,37-,53?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dC(Ac)-3'-Methoxy-phosphoramidite; 2'-F-Ac-dC-3'-Methoxy-phosphoramidite; 2'-F dC(Ac) OMe-amidite; 2'-F cytidine (N-Ac) Methoxy phosphoramidite; 2'-F C(Ac) OMe-amidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methoxy-phosphoramidite

Description: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methoxy-phosphoramidite is a specialized phosphoramidite reagent utilized in the synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group on the 5' hydroxyl group of the sugar, a 2'-fluoro modification on the deoxyribose sugar of uracil, and includes a 3'-methoxy-phosphoramidite functional group essential for solid-phase oligonucleotide synthesis. It is valuable in developing oligonucleotides for various applications, including RNA interference (RNAi), antisense therapy, and molecular diagnostics. Additionally, it supports research into nucleic acid structure, function, and interactions.

CAT: BRP-01555

CAS: 136671-61-9

Molecular Formula: C37H45FN3O8P

Molecular Weight: 709.75

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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InChIKey: NGPNMGRLSNMJIL-DYVNLQDQSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2F

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C37H45FN3O8P/c1-24(2)41(25(3)4)50(46-7)49-34-31(48-35(33(34)38)40-22-21-32(42)39-36(40)43)23-47-37(26-11-9-8-10-12-26,27-13-17-29(44-5)18-14-27)28-15-19-30(45-6)20-16-28/h8-22,24-25,31,33-35H,23H2,1-7H3,(H,39,42,43)/t31-,33-,34-,35-,50?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dU-3'-Methoxy-phosphoramidite; 2'-F-dU-3'-Methoxy-phosphoramidite; 2'-F U OMe-amidite; 2'-F uridine methyl phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine-3'-CE-Phosphoramidite

Description: 2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine-3'-CE-Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It features a 2'-fluoro modification on the deoxyribose sugar of inosine (I), combined with a cyanoethyl (CE) phosphoramidite functional group necessary for solid-phase oligonucleotide synthesis. It is valuable in developing modified oligonucleotides for various applications, including as probes for studying nucleic acid structure, as well as potential therapeutic applications such as antisense therapy and RNA interference (RNAi).

CAT: BRP-01556

CAS: 2245842-16-2

Molecular Formula: C40H46FN6O7P

Molecular Weight: 772.80

Purity: ≥98% by HPLC

Appearance: White powder

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InChIKey: GNQYQPLUWSYXRR-YRGZVQMCSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(6-oxo-1H-purin-9-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H46FN6O7P/c1-26(2)47(27(3)4)55(52-22-10-21-42)54-36-33(53-39(34(36)41)46-25-45-35-37(46)43-24-44-38(35)48)23-51-40(28-11-8-7-9-12-28,29-13-17-31(49-5)18-14-29)30-15-19-32(50-6)20-16-30/h7-9,11-20,24-27,33-34,36,39H,10,22-23H2,1-6H3,(H,43,44,48)/t33-,34-,36-,39-,55?/m1/s1

Synonyms: 2'-F-dI-CE-Phosphoramidite; 2'-F I amidite; 2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyinosine-3'-cyanoethyl phosphoramidite; 2'-F dI amidite

2'-F MeC(pac) amidite

Description: 2'-F MeC(pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. The 2'-fluorine modification enhances the stability of the RNA by increasing resistance to enzymatic degradation. The methylcytosine base modification can impact gene expression and epigenetic regulation. The phenoxyacetyl (pac) group serves as a protective group, ensuring the fidelity of synthesis. This amidite allows for the production of modified RNA sequences with improved stability and functional properties.

CAT: BRP-01557

Molecular Formula: C48H55FN5O9P

Molecular Weight: 895.97

Purity: >95%

Appearance: Off-white solid

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InChIKey: PBAZJAWJLKEWTI-UVFJTNPGSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(5-methyl-2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H55FN5O9P/c1-32(2)54(33(3)4)64(61-28-14-27-50)63-44-41(62-46(43(44)49)53-29-34(5)45(52-47(53)56)51-42(55)31-59-40-17-12-9-13-18-40)30-60-48(35-15-10-8-11-16-35,36-19-23-38(57-6)24-20-36)37-21-25-39(58-7)26-22-37/h8-13,15-26,29,32-33,41,43-44,46H,14,28,30-31H2,1-7H3,(H,51,52,55,56)/t41-,43-,44-,46-,64?/m1/s1

Synonyms: 5'-O-DMT-2'-F-MeC(pac) 3'-CE Phosphoramidite; 2'-F-MeC(pac) CE-Phosphoramidite; 2'-F-5-Me-dC(pac) CE-Phosphoramidite

2'-F MeC(dmf) amidite

Description: 2'-F MeC(dmf) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. This compound features a 2'-fluorine modification, which enhances the stability of the RNA by increasing its resistance to enzymatic degradation. The cytosine base in this amidite is methylated (MeC), which can play a role in gene expression and epigenetic regulation. The dimethylformamide (dmf) group acts as a protective group, ensuring the proper synthesis of the RNA strand by preventing unwanted side reactions. This amidite is crucial for producing modified RNA sequences with enhanced stability and functionality.

CAT: BRP-01558

Molecular Formula: C43H54FN6O7P

Molecular Weight: 816.91

Purity: >98%

Appearance: Off-white solid

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InChIKey: ADENSOMHVRAGEH-KZQAAKLLSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H54FN6O7P/c1-29(2)50(30(3)4)58(55-25-13-24-45)57-39-37(56-41(38(39)44)49-26-31(5)40(47-42(49)51)46-28-48(6)7)27-54-43(32-14-11-10-12-15-32,33-16-20-35(52-8)21-17-33)34-18-22-36(53-9)23-19-34/h10-12,14-23,26,28-30,37-39,41H,13,25,27H2,1-9H3/t37-,38-,39-,41-,58?/m1/s1

Synonyms: 5'-O-DMT-2'-F-MeC(dmf) 3'-CE Phosphoramidite; 2'-F-MeC(dmf) CE-Phosphoramidite; 2'-F-5-Me-dC(dmf) CE-Phosphoramidite

2'-F A(dmf) amidite

Description: 2'-F A(dmf) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. This compound includes a 2'-fluorine modification, which enhances RNA stability by increasing resistance to enzymatic degradation. The adenine base in this amidite has a dimethylformamide (dmf) protective group, which helps prevent unwanted side reactions during the synthesis process. This modification is crucial for producing RNA sequences with improved stability and integrity, facilitating their use in various research and therapeutic applications.

CAT: BRP-01559

Molecular Formula: C43H52FN8O6P

Molecular Weight: 826.91

Purity: >98%

Appearance: Off-white solid

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InChIKey: NOGLCHLULIFCJH-ZXYFHBOTSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-(((dimethylamino)methylene)amino)-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H52FN8O6P/c1-29(2)52(30(3)4)59(56-24-12-23-45)58-39-36(57-42(37(39)44)51-28-48-38-40(49-27-50(5)6)46-26-47-41(38)51)25-55-43(31-13-10-9-11-14-31,32-15-19-34(53-7)20-16-32)33-17-21-35(54-8)22-18-33/h9-11,13-22,26-30,36-37,39,42H,12,24-25H2,1-8H3/t36-,37-,39-,42-,59?/m1/s1

Synonyms: 2'-Fluoro-2'-deoxy Adenosine (N,N-DMF) CED Phosphoramidite; 5'-O-DMT-2'-F-A(dmf) 3'-CE Phosphoramidite; 2'-F-A(dmf) CE-Phosphoramidite; 2'-F-dA(dmf) 3'-CE-Phosphoramidite

2'-F A(pac) amidite

Description: 2'-F A(pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. The 2'-fluorine modification enhances the stability of the RNA by making it more resistant to enzymatic degradation. The adenine base in this amidite has a phenoxyacetyl (pac) protective group, which prevents unwanted side reactions during the synthesis process. This amidite is essential for producing RNA sequences with enhanced stability and integrity, making them suitable for various research and therapeutic applications.

CAT: BRP-01560

Molecular Formula: C48H53FN7O8P

Molecular Weight: 905.96

Purity: >95%

Appearance: Off-white solid

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InChIKey: IPGFEHRBBLWVPH-NNMVWRAKSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H53FN7O8P/c1-32(2)56(33(3)4)65(62-27-13-26-50)64-44-40(28-61-48(34-14-9-7-10-15-34,35-18-22-37(58-5)23-19-35)36-20-24-38(59-6)25-21-36)63-47(42(44)49)55-31-53-43-45(51-30-52-46(43)55)54-41(57)29-60-39-16-11-8-12-17-39/h7-12,14-25,30-33,40,42,44,47H,13,27-29H2,1-6H3,(H,51,52,54,57)/t40-,42-,44-,47-,65?/m1/s1

Synonyms: 2'-Fluoro-2'-deoxy Adenosine (Pac) CED Phosphoramidite; 5'-O-DMT-2'-F-A(Pac) 3'-CE Phosphoramidite; 2'-F-A(Pac) CE-Phosphoramidite; 2'-F-dA(Pac) 3'-CE-Phosphoramidite

2'-F C(pac) amidite

Description: 2'-F C(pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. The 2'-fluorine modification enhances the stability of the RNA by making it more resistant to enzymatic degradation. The cytosine base in this compound has a phenoxyacetyl (pac) group, which serves as a protective group during the synthesis process, preventing undesired reactions. This amidite allows for the production of RNA sequences with improved stability and integrity, facilitating various applications in research and therapeutics.

CAT: BRP-01561

Molecular Formula: C47H53FN5O9P

Molecular Weight: 881.94

Purity: >98%

Appearance: Off-white solid

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InChIKey: ARQJQDCNAYPRPA-DRPJRLOZSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H53FN5O9P/c1-32(2)53(33(3)4)63(60-29-13-27-49)62-44-40(61-45(43(44)48)52-28-26-41(51-46(52)55)50-42(54)31-58-39-16-11-8-12-17-39)30-59-47(34-14-9-7-10-15-34,35-18-22-37(56-5)23-19-35)36-20-24-38(57-6)25-21-36/h7-12,14-26,28,32-33,40,43-45H,13,29-31H2,1-6H3,(H,50,51,54,55)/t40-,43-,44-,45-,63?/m1/s1

Synonyms: 5'-O-DMT-2'-F-C(pac) 3'-CE Phosphoramidite; 2'-F-C(pac) CE-Phosphoramidite; 2'-F-dC(pac) CE-Phosphoramidite

2'-F G(iPr-pac) amidite

Description: 2'-F G(iPr-pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. This compound features a 2'-fluorine modification, which enhances RNA stability by increasing resistance to enzymatic degradation. The guanine base in this amidite is protected with an isopropyl phenoxyacetyl (iPr-pac) group, which prevents unwanted side reactions during the synthesis process. This amidite is crucial for producing RNA sequences with improved stability and integrity, facilitating their use in various research and therapeutic applications.

CAT: BRP-01562

Molecular Formula: C51H59FN7O9P

Molecular Weight: 964.04

Purity: >98%

Appearance: Off-white solid

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InChIKey: XMOAKDDRWSAKSB-PHZZPARGSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H59FN7O9P/c1-32(2)35-15-21-41(22-16-35)64-30-43(60)55-50-56-47-45(48(61)57-50)54-31-58(47)49-44(52)46(68-69(66-28-12-27-53)59(33(3)4)34(5)6)42(67-49)29-65-51(36-13-10-9-11-14-36,37-17-23-39(62-7)24-18-37)38-19-25-40(63-8)26-20-38/h9-11,13-26,31-34,42,44,46,49H,12,28-30H2,1-8H3,(H2,55,56,57,60,61)/t42-,44-,46-,49-,69?/m1/s1

Synonyms: 5'-O-DMT-2'-F-G(iPr-pac) 3'-CE Phosphoramidite; 2'-F-G(iPr-pac) CE-Phosphoramidite; 2'-F-dG(iPr-pac) 3'-CE-Phosphoramidite

5'-DMT-2'-F-dG(iBu)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dG(iBu)-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. This reagent is instrumental in automated DNA and RNA synthesis platforms, enabling the precise and reliable incorporation of modified nucleotides into sequence-defined oligonucleotides. The modifications introduced by 5'-DMT-2'-F-dG(iBu)-3'-PS-Phosphoramidite are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where improved stability, specificity, and functional properties of nucleic acids are essential.

CAT: BRP-01567

Molecular Formula: C48H52FN6O8PS2

Molecular Weight: 955.07

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: GOLSECBBKDTIRM-IMYAOLGDSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N7CCCC7)SCCSC(=O)C8=CC=CC=C8)F

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C48H52FN6O8PS2/c1-31(2)43(56)52-47-51-42-40(44(57)53-47)50-30-55(42)45-39(49)41(63-64(54-25-11-12-26-54)66-28-27-65-46(58)32-13-7-5-8-14-32)38(62-45)29-61-48(33-15-9-6-10-16-33,34-17-21-36(59-3)22-18-34)35-19-23-37(60-4)24-20-35/h5-10,13-24,30-31,38-39,41,45H,11-12,25-29H2,1-4H3,(H2,51,52,53,56,57)/t38-,39-,41-,45-,64?/m1/s1

Synonyms: [N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyguanosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; DMT-2'-F-dG(iBu)-3'-PS; 2'-F-dG-Thiophosphoramidite; 2'-F-dG(iBu)-Thiophosphoramidite

5'-DMT-2'-F-dC(Ac)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dC(Ac)-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. It is an essential reagent in automated DNA and RNA synthesis platforms, enabling the precise and reliable incorporation of modified cytidine nucleotides into sequence-defined oligonucleotides. These modifications are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where enhanced stability, specificity, and functional properties of nucleic acids are crucial.

CAT: BRP-01568

Molecular Formula: C45H48FN4O8PS2

Molecular Weight: 886.99

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: YEUOGNRGLBQTSU-ZMHKPELYSA-N

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C45H48FN4O8PS2/c1-31(51)47-39-24-27-50(44(53)48-39)42-40(46)41(58-59(49-25-10-11-26-49)61-29-28-60-43(52)32-12-6-4-7-13-32)38(57-42)30-56-45(33-14-8-5-9-15-33,34-16-20-36(54-2)21-17-34)35-18-22-37(55-3)23-19-35/h4-9,12-24,27,38,40-42H,10-11,25-26,28-30H2,1-3H3,(H,47,48,51,53)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxycytidine-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoramidite]; DMT-2'-F-dC(Ac)-3'-PS; 2'-F-dC-Thiophosphoramidite; 2'-F-dC(Ac)-Thiophosphoramidite

5'-DMT-2'-F-dA(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dA(Bz)-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. This reagent is used in automated DNA and RNA synthesis platforms to create modified oligonucleotides with precise sequences. These modifications are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where enhanced stability, specificity, and functional properties of nucleic acids are crucial.

CAT: BRP-01569

Molecular Formula: C51H50FN6O7PS2

Molecular Weight: 973.09

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: PPULOMKIQMTGHV-PDBKPMKASA-N

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C51H50FN6O7PS2/c1-61-40-24-20-38(21-25-40)51(37-18-10-5-11-19-37,39-22-26-41(62-2)27-23-39)63-32-42-45(65-66(57-28-12-13-29-57)68-31-30-67-50(60)36-16-8-4-9-17-36)43(52)49(64-42)58-34-55-44-46(53-33-54-47(44)58)56-48(59)35-14-6-3-7-15-35/h3-11,14-27,33-34,42-43,45,49H,12-13,28-32H2,1-2H3,(H,53,54,56,59)/t42-,43-,45-,49-,66?/m1/s1

Synonyms: [N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyadenosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; DMT-2'-F-dA(Bz)-3'-PS; 2'-F-dA-Thiophosphoramidite; 2'-F-dA(Bz)-Thiophosphoramidite

5'-DMT-2'-F-dU-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dU-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. It is an essential reagent in automated DNA and RNA synthesis platforms, enabling the precise and reliable incorporation of modified uridine nucleotides into sequence-defined oligonucleotides. These modifications are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where enhanced stability, specificity, and functional properties of nucleic acids are crucial.

CAT: BRP-01570

Molecular Formula: C43H45FN3O8PS2

Molecular Weight: 845.93

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: HUXZGSPNSAYIPS-CYSIDSPMSA-N

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C43H45FN3O8PS2/c1-51-34-19-15-32(16-20-34)43(31-13-7-4-8-14-31,33-17-21-35(52-2)22-18-33)53-29-36-39(38(44)40(54-36)47-26-23-37(48)45-42(47)50)55-56(46-24-9-10-25-46)58-28-27-57-41(49)30-11-5-3-6-12-30/h3-8,11-23,26,36,38-40H,9-10,24-25,27-29H2,1-2H3,(H,45,48,50)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: [5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxyuridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]; DMT-2'-F-dU-3'-PS; 2'-F-dU-Thiophosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxy-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

Description: 5'-O-DMTr-2'-ara-F-I-3'-CE-Phosphoramidite is a specialized phosphoramidite reagent used in the synthesis of modified oligonucleotides. It is valuable in developing oligonucleotides for various applications, including gene regulation, antisense therapy, and RNA interference (RNAi). Additionally, it supports research into nucleic acid structure, function, and interactions.

CAT: BRP-01571

Molecular Formula: C40H46FN6O7P

Molecular Weight: 772.80

Purity: ≥95% by HPLC

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

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InChIKey: GNQYQPLUWSYXRR-CAPOITNRSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(6-oxo-1H-purin-9-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

Synonyms: 5'-O-DMTr-2'-ara-F-I-3'-CE-Phosphoramidite; (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-arabinoinosine-3'-CE-Phosphoramidite

2'-F U Me-amidite

Description: 2'-F U Me-amidite is a phosphoramidite reagent used in the chemical synthesis of DNA oligonucleotides. This compound includes a 5'-O-DMTr protective group to safeguard the 5' hydroxyl group during synthesis, a 2'-fluorine modification to enhance stability against enzymatic degradation, and a 3'-methyl phosphoramidite for efficient incorporation into the growing DNA chain. This reagent is essential for creating modified DNA sequences with improved stability and integrity, suitable for various research and therapeutic applications.

CAT: BRP-01576

Molecular Formula: C37H45FN3O7P

Molecular Weight: 693.75

Purity: >95%

Appearance: Off-white solid

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InChIKey: XUSXWHAYFLUNDK-CGZUQJDWSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(C)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-methylphosphanyl]oxy-3-fluorooxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C37H45FN3O7P/c1-24(2)41(25(3)4)49(7)48-34-31(47-35(33(34)38)40-22-21-32(42)39-36(40)43)23-46-37(26-11-9-8-10-12-26,27-13-17-29(44-5)18-14-27)28-15-19-30(45-6)20-16-28/h8-22,24-25,31,33-35H,23H2,1-7H3,(H,39,42,43)/t31-,33-,34-,35-,49?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methyl-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-Methyl-phosphoramidite; 2'-F-dU-3'-Methyl-phosphoramidite; 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-F dU Me-amidite

2'-F C(Ac) Me-amidite

Description: 2'-F C(Ac) Me-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01577

Molecular Formula: C39H48FN4O7P

Molecular Weight: 734.81

Purity: >95%

Appearance: Off-white solid

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InChIKey: KBVMZEMFKQCECY-SGXIJWRWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C39H48FN4O7P/c1-25(2)44(26(3)4)52(8)51-36-33(50-37(35(36)40)43-23-22-34(41-27(5)45)42-38(43)46)24-49-39(28-12-10-9-11-13-28,29-14-18-31(47-6)19-15-29)30-16-20-32(48-7)21-17-30/h9-23,25-26,33,35-37H,24H2,1-8H3,(H,41,42,45,46)/t33-,35-,36-,37-,52?/m1/s1

Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-Methyl-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-Methyl-phosphoramidite; 2'-F-Ac-dC-3'-Methyl-phosphoramidite; 2'-F dC(Ac) Me-amidite; 2'-F cytidine (N-Ac) methyl phosphoramidite

2'-F A(Bz) Me-amidite

Description: 2'-F A(Bz) Me-amidite is a phosphoramidite reagent utilized in the synthesis of DNA oligonucleotides. This compound features a benzoyl group at the N6 position of the adenine base, providing protection during synthesis. The 5'-O-(4,4'-dimethoxytrityl) group shields the 5' hydroxyl group of the nucleoside, facilitating controlled assembly of the oligonucleotide chain. A fluorine atom at the 2' position of the deoxyribose sugar enhances the oligonucleotide's stability against enzymatic degradation. The 3'-methyl phosphoramidite moiety enables efficient coupling reactions for precise incorporation into DNA sequences, essential for various biomedical and genetic applications.

CAT: BRP-01578

Molecular Formula: C45H50FN6O6P

Molecular Weight: 820.90

Purity: >95%

Appearance: Off-white solid

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InChIKey: UCNMOPCADOGMJE-GBNBITQMSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C45H50FN6O6P/c1-29(2)52(30(3)4)59(7)58-40-37(57-44(38(40)46)51-28-49-39-41(47-27-48-42(39)51)50-43(53)31-14-10-8-11-15-31)26-56-45(32-16-12-9-13-17-32,33-18-22-35(54-5)23-19-33)34-20-24-36(55-6)25-21-34/h8-25,27-30,37-38,40,44H,26H2,1-7H3,(H,47,48,50,53)/t37-,38-,40-,44-,59?/m1/s1

Synonyms: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methyl-phosphoramidite; 5'-O-DMTr-2'-F-dA(Bz)-3'-methyl-phosphoramidite; 2'-F dA(Bz) Me-amidite; 2'-F adenosine (N-Bz) methyl phosphoramidite

2'-F G(iBu) Me-amidite

Description: 2'-F G(iBu) Me-amidite is a phosphoramidite reagent used in DNA oligonucleotide synthesis. It incorporates a modified guanine nucleotide with a fluorine atom at the 2' position of the sugar, enhancing stability against enzymatic degradation. The nucleoside is protected at the 5' position with a 4,4'-dimethoxytrityl group and at the N2 position with an isobutyryl group, facilitating controlled synthesis and modification of DNA sequences for diverse biological and therapeutic applications.

CAT: BRP-01579

Molecular Formula: C42H52FN6O7P

Molecular Weight: 802.88

Purity: >95%

Appearance: Off-white solid

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InChIKey: CCVHKDPSLDLLHS-CDTSKKGKSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C42H52FN6O7P/c1-25(2)38(50)46-41-45-37-35(39(51)47-41)44-24-48(37)40-34(43)36(56-57(9)49(26(3)4)27(5)6)33(55-40)23-54-42(28-13-11-10-12-14-28,29-15-19-31(52-7)20-16-29)30-17-21-32(53-8)22-18-30/h10-22,24-27,33-34,36,40H,23H2,1-9H3,(H2,45,46,47,50,51)/t33-,34-,36-,40-,57?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-methyl-phosphoramidite; 5'-O-DMTr-2'-F-dG(iBu)-3'-methyl-phosphoramidite; 2'-F dG(iBu) Me-amidite; 2'-F Guanosine (n-ibu) methyl phosphoramidite

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-methoxy-phosphoramidite

N6-Bz-5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methoxy-phosphoramidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-methoxy-phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methoxy-phosphoramidite

2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine-3'-CE-Phosphoramidite

2'-F MeC(pac) amidite

2'-F MeC(dmf) amidite

2'-F A(dmf) amidite

2'-F A(pac) amidite

2'-F C(pac) amidite

2'-F G(iPr-pac) amidite

5'-DMT-2'-F-dG(iBu)-3'-PS-Phosphoramidite

5'-DMT-2'-F-dC(Ac)-3'-PS-Phosphoramidite

5'-DMT-2'-F-dA(Bz)-3'-PS-Phosphoramidite

5'-DMT-2'-F-dU-3'-PS-Phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxy-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

2'-F U Me-amidite

2'-F C(Ac) Me-amidite

2'-F A(Bz) Me-amidite

2'-F G(iBu) Me-amidite

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