What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

5-O-DMTr-1-O-Ac-2-F-2-deoxyribofuranose-3-CE-Phosphoramidite

Description: 5-O-DMTr-1-O-Ac-2-F-2-deoxyribofuranose-3-CE-Phosphoramidite is a phosphoramidite reagent used in oligonucleotide synthesis. It features a deoxyribose sugar with specific modifications: the 5'-hydroxyl group is protected by a dimethoxytrityl (DMTr) group, the 1'-hydroxyl group is acetylated (Ac), and a fluorine atom is substituted at the 2' position. These modifications enhance the stability and functionality of the nucleic acids. The 3'-cyanoethyl (CE) phosphoramidite group is crucial for the automated synthesis process, enabling efficient and precise addition of this modified sugar to the growing oligonucleotide chain. This reagent is valuable in the synthesis of stable and functional nucleic acid sequences for various research and therapeutic applications.

CAT: BRP-01606

Molecular Formula: C37H46FN2O8P

Molecular Weight: 696.75

Purity: ≥95% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: YXVIYDHRSOENQP-NDCODMSPSA-N

IUPAC Name: (3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl acetate

InChI: InChI=1S/C37H46FN2O8P/c1-25(2)40(26(3)4)49(45-23-11-22-39)48-35-33(47-36(34(35)38)46-27(5)41)24-44-37(28-12-9-8-10-13-28,29-14-18-31(42-6)19-15-29)30-16-20-32(43-7)21-17-30/h8-10,12-21,25-26,33-36H,11,23-24H2,1-7H3/t33-,34-,35-,36?,49?/m1/s1

Synonyms: 5-O-(4,4'-Dimethoxytrityl)-1-O-acetyl-2-fluoro-2-deoxyribofuranose-3-cyanoethyl Phosphoramidite

5-DMTr-2-F-1,2-dideoxyribose-3-CE-Phosphoramidite

Description: 5-DMTr-2-F-1,2-dideoxyribose-3-CE-Phosphoramidite is a key reagent in the synthesis of modified oligonucleotides, featuring a dideoxyribose sugar with a 5'-dimethoxytrityl (DMTr) protective group and a fluorine atom at the 2' position. The dideoxyribose lacks hydroxyl groups at both the 1' and 2' positions, except for the 3'-hydroxyl, which is modified with a cyanoethyl (CE) phosphoramidite group. This design increases the stability of the oligonucleotide and prevents chain extension at the 2' position. This reagent is particularly useful for creating stable, modified oligonucleotides for use in various molecular biology and therapeutic applications.

CAT: BRP-01607

Molecular Formula: C35H44FN2O6P

Molecular Weight: 638.72

Purity: ≥98% by HPLC

Appearance: White or off-white to faint yellow solid

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InChIKey: CYNXGQPRPXHCQI-PRVDSXFMSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(COC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)F

IUPAC Name: 3-[[(2R,3R,4S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C35H44FN2O6P/c1-25(2)38(26(3)4)45(43-22-10-21-37)44-34-32(36)23-41-33(34)24-42-35(27-11-8-7-9-12-27,28-13-17-30(39-5)18-14-28)29-15-19-31(40-6)20-16-29/h7-9,11-20,25-26,32-34H,10,22-24H2,1-6H3/t32-,33+,34-,45?/m0/s1

Synonyms: 5-O-(4,4'-Dimethoxytrityl)-2-fluoro-1-deoxyribose-3-cyanoethyl Phosphoramidite; (2R,3R,4S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

3'-F-3'-dA(Bz)-2'-phosphoramidite

Description: 3'-F-3'-dA(Bz)-2'-phosphoramidite, an indispensable compound widely employed in the biomedical sector for the synthesis of oligonucleotides and nucleic acid analogs, holds paramount importance. Its modified structure renders it adept at enhancing stability, selectivity, and binding properties.

CAT: BRP-01609

CAS: 2127174-09-6

Molecular Formula: C47H51FN7O7P

Molecular Weight: 875.92

Purity: ≥95%

Appearance: Off-white solid

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InChIKey: WTXSTLCSPVTJTM-MSIRFHFKSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)F

IUPAC Name: (2R,3S,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-40(48)39(61-46(42)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1

Synonyms: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-deoxy-3'-fluoroadenosine-2'-CED-phosphoramidite; N-[9-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-fluorooxolan-2-yl]purin-6-yl]benzamide; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-3'-deoxy-3'-fluoroadenosine; 5'-DMT-3'-fluoro-DA(BZ) amidite; 3'-F A(Bz) 2'-amidite

Cholesterol C6 amine amidite (BRP-01617)

Description: Cholesterol C6 amine amidite is a powerful substance that functions to combat hypercholesterolemia and various lipid disorders. Using innovative technology, it works to inhibit cholesterol synthesis in the liver, leading to the reduction of overall blood cholesterol levels. Due to its notable and demonstrated effectiveness, it is highly regarded and widely employed within the biopharmaceutical industry in the treatment of cardiovascular diseases.

CAT: BRP-01617

CAS: 143723-64-2

Molecular Formula: C43H76N3O4P

Molecular Weight: 730.07

Purity: >95%

Appearance: Light-yellow oily matter

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Boiling Point: 722.5±60.0 °C at 760 mmHg

InChIKey: LLDRAIRYAJXEEP-CRQKJHHESA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)NCCCCCCOP(N(C(C)C)C(C)C)OCCC#N)C)C

IUPAC Name: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]carbamate

InChI: InChI=1S/C43H76N3O4P/c1-31(2)16-14-17-34(7)38-20-21-39-37-19-18-35-30-36(22-24-42(35,8)40(37)23-25-43(38,39)9)50-41(47)45-27-12-10-11-13-28-48-51(49-29-15-26-44)46(32(3)4)33(5)6/h18,31-34,36-40H,10-17,19-25,27-30H2,1-9H3,(H,45,47)/t34-,36+,37+,38-,39+,40+,42+,43-,51?/m1/s1

Synonyms: Cholest-5-en-3-ol (3β)-, 3-[[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl]carbamate]; Cholest-5-en-3-ol (3β)-, [6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl]carbamate; Cholesteryl-3-carboxamidohexyl-[2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Cholest-5-en-3-ol, 3-(6-(((2-cyanoethoxy)(diisopropylamino)phosphino)oxy)hexyl)carbemate; 5'-Cholesterol-CE-Phosphoramidite; Cholesteryl-3-carboxamidohexyl-[2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

U-(S)-GNA phosphoramidite

Description: U-(S)-GNA phosphoramidite, a chemical reagent frequently employed in the synthesis of modified oligonucleotides, has demonstrated its utility in the development of RNA therapeutics for diseases spanning cancer to viral infections. The structural distinctiveness of this reagent affords the resulting oligonucleotides improved stability and efficacy.

CAT: BRP-01619

CAS: 494784-15-5

Molecular Formula: C37H45N4O7P

Molecular Weight: 688.75

Purity: ≥98%

Appearance: Light yellow solid

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InChIKey: KZZGGKJIAMPACS-AQXIKWHWSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CN1C=CC(=O)NC1=O)COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC

IUPAC Name: 3-[[(2S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-(2,4-dioxopyrimidin-1-yl)propan-2-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C37H45N4O7P/c1-27(2)41(28(3)4)49(47-24-10-22-38)48-34(25-40-23-21-35(42)39-36(40)43)26-46-37(29-11-8-7-9-12-29,30-13-17-32(44-5)18-14-30)31-15-19-33(45-6)20-16-31/h7-9,11-21,23,27-28,34H,10,24-26H2,1-6H3,(H,39,42,43)/t34-,49?/m0/s1

Synonyms: GNA U amidite; Phosphoramidous acid, bis(1-methylethyl)-, (1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl]ethyl 2-cyanoethyl ester; (S)-GNA-U-phosphoramidite; DMT-U-(S)-GNA Phosphoramidite; (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(2,4-dioxo-3, 4-dihydropyrimidin-1(2H)-yl)propan-2-yl(2-cyanoethyl)diisopropylphosphoramidite

N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'-CE-phosphoramidite

Description: N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'-CE-phosphoramidite is a highly specialized chemical compound utilized in the synthesis of novel RNA molecules. Its unparalleled structural complexity enables precise targeting of malignant cells, paving the way for enhanced efficacy in RNA-based therapeutics that aim to alleviate various ailments, such as cancer and viral infections. Such unprecedented capability in modulating gene expression makes N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'-CE-phosphoramidite an invaluable tool in cutting-edge genetic research.

CAT: BRP-01620

CAS: 179479-02-8

Molecular Formula: C48H54N7O8P

Molecular Weight: 887.97

Purity: >95%

Appearance: Off-white solid

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InChIKey: FVQVZAFXDJSVIC-PSVHYZMASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-methoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-43-42(59-7)40(62-47(43)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1

Synonyms: N6-BZ-5'-O-DMTr-3'-O-methyladenosine-2'-O-CED-phosphoramidite; 3'-OMe A(Bz) 2'-amidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-methyladenosine-2'-cyanoethyl phosphoramidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-methyl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 3'-O-Me-A(Bz)-2'-phosphoramidite; 3'-OMe-A(Bz) Phosphoramidite; 3'-O-Methyl Adenosine (n-bz) CED phosphoramidite

RSPACER CEP

Description: RSPACER CEP is a biomedical product designed to study Chronic Exertional Compartment Syndrome.

CAT: BRP-01621

CAS: 159299-31-7

Molecular Formula: C41H59N2O7PSi

Molecular Weight: 750.99

Purity: >95%

Appearance: Off-white solid

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InChIKey: URLPBMMJULLWTE-ZEGDCKMFSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(COC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)O[Si](C)(C)C(C)(C)C

IUPAC Name: 3-[[(2R,3R,4S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H59N2O7PSi/c1-30(2)43(31(3)4)51(48-27-15-26-42)49-39-37(46-28-38(39)50-52(10,11)40(5,6)7)29-47-41(32-16-13-12-14-17-32,33-18-22-35(44-8)23-19-33)34-20-24-36(45-9)25-21-34/h12-14,16-25,30-31,37-39H,15,27-29H2,1-11H3/t37-,38+,39-,51?/m1/s1

Synonyms: 5'-O-Dimethoxytrityl-1'-Deoxyribose-2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; rSpacer TBDMS CE Phosphoramidite; 2'-OTBS abasic amidite; D-Ribitol, 1,4-anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; D-Ribitol, 1,4-anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2-cyanoethyl bis(1-methylethyl)phosphoramidite

2-Isobutyrylamino-9-(2'-O-tert-butyldimethylsilyl-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite

Description: 2-Isobutyrylamino-9-(2'-O-tert-butyldimethylsilyl-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite is an essential component in oligonucleotide synthesis for the biomedical industry. It is used in the modification and synthesis of nucleotide sequences targeting specific genes or diseases. Its unique properties allow for efficient and accurate incorporation into DNA and RNA strands, enabling researchers to study and develop therapeutic interventions for various conditions.

CAT: BRP-01622

CAS: 179558-91-9

Molecular Formula: C50H68N7O8PSi

Molecular Weight: 954.20

Purity: >95%

Appearance: Off-white solid

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InChIKey: XJRKARXGQAQMRG-KAZSGHHBSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CCCC(=O)NC1=NC=C2C(=N1)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-2-yl]butanamide

InChI: InChI=1S/C50H68N7O8PSi/c1-13-18-43(58)54-48-52-31-41-46(55-48)56(33-53-41)47-45(65-67(11,12)49(6,7)8)44(64-66(62-30-17-29-51)57(34(2)3)35(4)5)42(63-47)32-61-50(36-19-15-14-16-20-36,37-21-25-39(59-9)26-22-37)38-23-27-40(60-10)28-24-38/h14-16,19-28,31,33-35,42,44-45,47H,13,17-18,30,32H2,1-12H3,(H,52,54,55,58)/t42-,44-,45-,47-,66?/m1/s1

Synonyms: 2'-OTBS 2-amino(iBu)purine amidite; N-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]butanamide

2'-OMe N3-Me-U amidite

Description: Uridine 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3-methyl-2'-O-methyl-3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI) finds utility as a phosphoramidite constituent in the construction of distinct DNA sequences for investigative purposes. Uridine analogues, including the aforementioned derivative, have been explored for therapeutic uses against a spectrum of neurological and psychiatric maladies, hence providing an avenue for potential drug discovery.

CAT: BRP-01623

CAS: 911836-90-3

Molecular Formula: C41H51N4O9P

Molecular Weight: 774.84

Purity: >95%

Appearance: Off-white solid

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InChIKey: SKKGCWPFTMKRMD-BNPGDSBPSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)N(C2=O)C)C1OC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H51N4O9P/c1-28(2)45(29(3)4)55(52-26-12-24-42)54-37-35(53-39(38(37)50-8)44-25-23-36(46)43(5)40(44)47)27-51-41(30-13-10-9-11-14-30,31-15-19-33(48-6)20-16-31)32-17-21-34(49-7)22-18-32/h9-11,13-23,25,28-29,35,37-39H,12,26-27H2,1-8H3/t35-,37-,38-,39-,55?/m1/s1

Synonyms: 5'-O-DMTr-N3-methyl-2'-O-methyluridine 3'-CED phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3-methyl-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

2'-O-tert-Butyldimethylsilyl-5-O-DMT-nebularine 3'-CE phosphoramidite

Description: 2'-O-tert-Butyldimethylsilyl-5-O-DMT-nebularine 3'-CE phosphoramidite is a cutting-edge substance harboring extraordinary potential, catalyzing the research and development of tailored oligonucleotides, augmenting the efficiency and precision of nucleic acid sequence alterations.

CAT: BRP-01624

CAS: 151132-95-5

Molecular Formula: C46H61N6O7PSi

Molecular Weight: 869.07

Purity: >95%

Appearance: Off-white solid

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InChIKey: PPQDUERYNRWJQB-DFDZFBLHSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=CN=CN=C32)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-purin-9-yloxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C46H61N6O7PSi/c1-32(2)52(33(3)4)60(56-27-15-26-47)58-41-40(57-44(42(41)59-61(10,11)45(5,6)7)51-31-50-39-28-48-30-49-43(39)51)29-55-46(34-16-13-12-14-17-34,35-18-22-37(53-8)23-19-35)36-20-24-38(54-9)25-21-36/h12-14,16-25,28,30-33,40-42,44H,15,27,29H2,1-11H3/t40-,41-,42-,44-,60?/m1/s1

Synonyms: 9-(2'-O-tert-Butyldimethylsilyl-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite; 2'-OTBS Purine amidite; 9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purine; Nebularine 3''-CE phosphoramidite; Purine Riboside CED phosphoramidite

Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Description: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is an exceptional and multifarious pharmaceutical compound. With its distinctive chemical configuration, this exquisite compound exerts effects in research of a range of maladies including cancers and viral infections.

CAT: BRP-01625

CAS: 1253796-11-0

Molecular Formula: C48H66N5O9PSi

Molecular Weight: 916.12

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: HWLSHLFHYPXASQ-HXZVCAGESA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=NC2=O)N(C)C(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]-N-methylacetamide

InChI: InChI=1S/C48H66N5O9PSi/c1-33(2)53(34(3)4)63(59-31-17-29-49)61-43-41(60-45(44(43)62-64(12,13)47(6,7)8)52-30-28-42(50-46(52)55)51(9)35(5)54)32-58-48(36-18-15-14-16-19-36,37-20-24-39(56-10)25-21-37)38-22-26-40(57-11)27-23-38/h14-16,18-28,30,33-34,41,43-45H,17,31-32H2,1-13H3/t41-,43-,44-,45-,63?/m1/s1

Synonyms: 2'-OTBS C(Me,Ac) amidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-(N-methylacetamido)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; N4-Acetyl-5'-O-DMTr-2'-O-TBDMS-N4-methyl cytidine 3'-CED phosphoramidite

2'-OTBS N3-Me-U amidite

Description: 2'-OTBS N3-Me-U amidite is a vital compound used in the field of biomedicine. With its therapeutic properties, this product is utilized for the development of targeted drugs catering to specific drug delivery systems, gene therapy, and immunotherapy.

CAT: BRP-01627

CAS: 179762-50-6

Molecular Formula: C46H63N4O9PSi

Molecular Weight: 875.07

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: BFLRLATZTWPEAW-SRYSXPHVSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=O)N(C2=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(3-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C46H63N4O9PSi/c1-32(2)50(33(3)4)60(56-30-16-28-47)58-41-39(57-43(42(41)59-61(11,12)45(5,6)7)49-29-27-40(51)48(8)44(49)52)31-55-46(34-17-14-13-15-18-34,35-19-23-37(53-9)24-20-35)36-21-25-38(54-10)26-22-36/h13-15,17-27,29,32-33,39,41-43H,16,30-31H2,1-12H3/t39-,41-,42-,43-,60?/m1/s1

Synonyms: 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-3-methyluridine 3'-CE phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-3-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; N3-Methyl Uridine CED phosphoramidite

Boc-PNA-G(Z)-OH

Description: Boc-PNA-G(Z)-OH is a synthetic peptide nucleic acid (PNA) monomer with a guanine base. It features a Boc (tert-butyloxycarbonyl) protecting group and a Z (benzyloxycarbonyl) group, commonly used in the synthesis of PNA oligomers for research in molecular biology and genetics, particularly in the study of DNA and RNA binding.

CAT: BRP-01691

CAS: 169287-77-8

Molecular Formula: C24H29N7O8

Molecular Weight: 543.54

Purity: ≥97% by HPLC

Appearance: White to Off-white Powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.44±0.1 g/cm3

InChIKey: QPFRXGPXBKQVPU-UHFFFAOYSA-N

CanonicalSMILES: CC(C)(C)OC(=O)NCCN(CC(=O)O)C(=O)CN1C=NC2=C1N=C(NC2=O)NC(=O)OCC3=CC=CC=C3

IUPAC Name: 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl-[2-[6-oxo-2-(phenylmethoxycarbonylamino)-1H-purin-9-yl]acetyl]amino]acetic acid

InChI: InChI=1S/C24H29N7O8/c1-24(2,3)39-22(36)25-9-10-30(12-17(33)34)16(32)11-31-14-26-18-19(31)27-21(28-20(18)35)29-23(37)38-13-15-7-5-4-6-8-15/h4-8,14H,9-13H2,1-3H3,(H,25,36)(H,33,34)(H2,27,28,29,35,37)

Synonyms: N-((N2-(Benzyloxycarbonyl)guanine-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycine; Boc-G(Z)-Aeg-OH; Glycine, N-[[1,6-dihydro-6-oxo-2-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl]acetyl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-; N-[2-[1,6-Dihydro-6-oxo-2-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl]acetyl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]glycine

N6-Benzoyl-2'-tert-butyldimethylsilyl-7-deaza-5'-O-DMT-adenosine 3'-CE phosphoramidite

Description: N6-Benzoyl-2'-tert-butyldimethylsilyl-7-deaza-5'-O-DMT-adenosine 3'-CE phosphoramidite is essential for the synthesis of modified nucleic acids used in the research of various diseases. Its unique structure enables the introduction of N6-benzoyl, 2-tert-butyldimethylsilyl and 7-deaza functionalities into adenosine ideal for developing nucleoside analogs and exploring novel therapeutic strategies.

CAT: BRP-01716

CAS: 144994-95-6

Molecular Formula: C54H67N6O8PSi

Molecular Weight: 987.20

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InChIKey: MUWOVNLLXDFHQS-QUWBCMLWSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[7-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]benzamide

InChI: InChI=1S/C54H67N6O8PSi/c1-37(2)60(38(3)4)69(65-34-18-32-55)67-47-46(35-64-54(40-21-16-13-17-22-40,41-23-27-43(62-8)28-24-41)42-25-29-44(63-9)30-26-42)66-52(48(47)68-70(10,11)53(5,6)7)59-33-31-45-49(56-36-57-50(45)59)58-51(61)39-19-14-12-15-20-39/h12-17,19-31,33,36-38,46-48,52H,18,34-35H2,1-11H3,(H,56,57,58,61)/t46-,47-,48-,52-,69?/m1/s1

Synonyms: 7-Deaza Adenosine CED phosphoramidite; 7-Deaza 2'-TDDMS Adenosine(Bz) 3'-CE phosphoramidite; 7-Deaza-Adenosine CEP; N6-Benzoyl-2'-tert-butyldimethylsilyl-7-deaza-5'-O-DMT-D-adenosine 3'-CE phosphoramidite; N-[7-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzamide; Phosphoramidous acid, bis(1-methylethyl)-, mono(2-cyanoethyl) ester, ester with N-[7-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzamide

DMTr-FNA-C(Bz)phosphoramidite

Description: DMTr-FNA-C(Bz)phosphoramidite is an essential compound assuming the role of a phosphoramidite foundational component, expediting the fabrication of nucleic acid analogs. Through its distinctive configuration, it is harnessed in the fabrication of modified oligonucleotides, specifically tailored for investigative applications, notably in the precise targeting of disease-correlated DNA or RNA sequences encompassing afflictions like cancer and viral infections.

CAT: BRP-01746

CAS: 326802-62-4

Molecular Formula: C45H52N5O8P

Molecular Weight: 821.90

Purity: ≥95%

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InChIKey: KYJJUEVQJPBHPG-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OCN4C=CC(=NC4=O)NC(=O)C5=CC=CC=C5

IUPAC Name: N-[1-[[1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropan-2-yl]oxymethyl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C45H52N5O8P/c1-33(2)50(34(3)4)59(57-29-13-27-46)58-31-41(55-32-49-28-26-42(48-44(49)52)47-43(51)35-14-9-7-10-15-35)30-56-45(36-16-11-8-12-17-36,37-18-22-39(53-5)23-19-37)38-20-24-40(54-6)25-21-38/h7-12,14-26,28,33-34,41H,13,29-32H2,1-6H3,(H,47,48,51,52)

Synonyms: FNA C(Bz) amidite; N4-Benzoyl-1-[[2-O-(4,4'-dimethoxytrityloxy)-1-(hydroxymethyl)ethoxy]methyl]cytosine CED phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-[[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]methoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; 2-((4-Benzamido-2-oxopyrimidin-1(2H)-yl)methoxy)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite

5'-O-DMT-2'-O-TBDMS-N4-Benzoyl-5-Methy-Cytidine 3'-CE phosphoramidite (BRP-01747)

Description: The 5'-O-DMT-2'-O-TBDMS-N4-Benzoyl-5-Methy-Cytidine 3'-CE phosphoramidite, an indispensable tool in biomedicine, is utilized for oligonucleotide synthesis. Its application extends to treatments for cancer, viral infections, and genetic disorders, imparting significant progress in medical science. This product aptly aids the creation of innovative drugs and therapies that can possibly enhance patient outcomes.

CAT: BRP-01747

CAS: 160107-14-2

Molecular Formula: C53H68N5O9PSi

Molecular Weight: 978.21

Purity: ≥98% by HPLC

Appearance: White to Off-white powder

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Storage: Store at -20 °C

InChIKey: CSRPNZIUSKVNCV-YIZRFDMBSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C

InChI: InChI=1S/C53H68N5O9PSi/c1-36(2)58(37(3)4)68(64-33-19-32-54)66-46-45(35-63-53(40-22-17-14-18-23-40,41-24-28-43(61-9)29-25-41)42-26-30-44(62-10)31-27-42)65-50(47(46)67-69(11,12)52(6,7)8)57-34-38(5)48(56-51(57)60)55-49(59)39-20-15-13-16-21-39/h13-18,20-31,34,36-37,45-47,50H,19,33,35H2,1-12H3,(H,55,56,59,60)/t45-,46-,47-,50-,68?/m1/s1

Synonyms: 5-Methyl Cytidine CED phosphoramidite; 5-Me-DMT-2'-O-TBDMS-C(Bz)-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

5'-Amino-modifier-C12-DMT CEP

Description: 5'-Amino-modifier-C12-DMT CEP is a specialized reagent used in the synthesis of oligonucleotides. It features a 5'-amino modifier with a C12 spacer arm and a dimethoxytrityl (DMT) protecting group, along with a cyanoethyl phosphoramidite (CEP) functionality. The C12 spacer provides flexibility and distance between the oligonucleotide and the amino group, which can be used for further conjugation to other molecules. This compound is crucial for introducing functional groups at the 5' end of oligonucleotides, allowing for applications such as labeling, cross-linking, and attachment to solid supports in molecular biology and biotechnology research.

CAT: BRP-01750

CAS: 1027512-19-1

Molecular Formula: C42H62N3O4P

Molecular Weight: 703.94

Purity: ≥97%

Appearance: Colorless to light yellow oily matter

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Storage: Store at -20 °C

InChIKey: FBYPUBVKUIZLQQ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCCCCCCCNC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 12-((bis(4-methoxyphenyl)(phenyl)methyl)amino)dodecyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H62N3O4P/c1-35(2)45(36(3)4)50(49-34-20-31-43)48-33-19-14-12-10-8-7-9-11-13-18-32-44-42(37-21-16-15-17-22-37,38-23-27-40(46-5)28-24-38)39-25-29-41(47-6)30-26-39/h15-17,21-30,35-36,44H,7-14,18-20,32-34H2,1-6H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 12-[[bis(4-methoxyphenyl)phenylmethyl]amino]dodecyl 2-cyanoethyl ester; DMT-C12-amine-linker amidite; 12-[[Bis(4-methoxyphenyl)phenylmethyl]amino]dodecyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

N4-Benzoyl-7'-OH-N-trityl morpholino cytosine

Description: N4-Benzoyl-7'-OH-N-trityl morpholino cytosine is a chemical compound used in biomedical research for its potential as an antiviral agent. It exhibits activity against certain viruses by targeting specific viral enzymes and inhibiting their replication. This compound holds promise in the development of treatments for various viral infections, contributing to advancements in biomedicine.

CAT: BRP-01765

CAS: 125515-31-3

Molecular Formula: C35H32N4O4

Molecular Weight: 572.65

Purity: ≥95%

Appearance: White Solid

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Storage: Store at RT

Density: 1.24±0.1 g/cm3 (Predicted)

Melting Point: >225 °C

InChIKey: DMFVVKPXZHMPKX-XDFJSJKPSA-N

CanonicalSMILES: C1C(OC(CN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)CO

IUPAC Name: N-[1-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C35H32N4O4/c40-25-30-23-38(24-32(43-30)39-22-21-31(37-34(39)42)36-33(41)26-13-5-1-6-14-26)35(27-15-7-2-8-16-27,28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-22,30,32,40H,23-25H2,(H,36,37,41,42)/t30-,32+/m0/s1

Synonyms: N4-Benzoyl-7'-hydroxy-N-trityl-morpholino cytosine monomer; N-{1-[(2R,6S)-6-(Hydroxymethyl)-4-trityl-2-morpholinyl]-2-oxo-1,2-dihydro-4-pyrimidinyl}benzamide; Benzamide, N-[1,2-dihydro-1-[6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-2-oxo-4-pyrimidinyl]-, (2R-cis)-; N-[1,2-Dihydro-1-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-2-oxo-4-pyrimidinyl]benzamide; N-(1-[(2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholine-2-yl]-2-oxo-1,2-dihydropyrimidine-4-yl)benzamide; N-[1-[(2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]benzamide; N-[1-[(2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxo-1,2-dihydropyrimidine-4-yl]benzamide

N-(9-((2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl)-6-(4-nitrophenethoxy)-9H-purin-2-yl)isobutyramide

Description: N-(9-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-6-(4-nitrophenethoxy)-9H-purin-2-yl)isobutyramide is an intriguing pharmaceutical compound, designed to study certain ailments. Its distinct mechanism of action involves inhibition of cellular processes closely tied to the expansion of malignant cells.

CAT: BRP-01767

Molecular Formula: C41H41N7O6

Molecular Weight: 727.82

Purity: >98%

Appearance: White to light yellow powder

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InChIKey: MZOWZACWEAZPAK-OIDHKYIRSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=N1)OCCC3=CC=C(C=C3)[N+](=O)[O-])N=CN2C4CN(CC(O4)CO)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

IUPAC Name: N-[9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-6-[2-(4-nitrophenyl)ethoxy]purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C41H41N7O6/c1-28(2)38(50)44-40-43-37-36(39(45-40)53-23-22-29-18-20-33(21-19-29)48(51)52)42-27-47(37)35-25-46(24-34(26-49)54-35)41(30-12-6-3-7-13-30,31-14-8-4-9-15-31)32-16-10-5-11-17-32/h3-21,27-28,34-35,49H,22-26H2,1-2H3,(H,43,44,45,50)/t34-,35+/m0/s1

Synonyms: 7'-OH-O6-[2-(4-Nitrophenyl)ethyl]-N2-isobutyryl-N-trityl morpholino guanosine; Morpholino G subunit; N-(9-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-6-(4-nitrophenethoxy)-9H-purin-2-yl)isobutyramide

N2-Isobutyryl-O6-cyanoethyl-7'-OH-N-trityl-morpholino guanine

Description: N2-Isobutyryl-O6-cyanoethyl-7'-OH-N-trityl-morpholino guanine is a biomedical compound possessing remarkable antiviral potential used for stuyding specific viral infections.

CAT: BRP-01792

CAS: 2305415-83-0

Molecular Formula: C36H37N7O4

Molecular Weight: 631.72

Purity: ≥95%

Appearance: White solid

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Density: 1.29±0.1 g/cm3

InChIKey: SWIWEMMZHYDBHD-XZWHSSHBSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=N1)OCCC#N)N=CN2C3CN(CC(O3)CO)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

IUPAC Name: N-[6-(2-cyanoethoxy)-9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C36H37N7O4/c1-25(2)33(45)40-35-39-32-31(34(41-35)46-20-12-19-37)38-24-43(32)30-22-42(21-29(23-44)47-30)36(26-13-6-3-7-14-26,27-15-8-4-9-16-27)28-17-10-5-11-18-28/h3-11,13-18,24-25,29-30,44H,12,20-23H2,1-2H3,(H,39,40,41,45)/t29-,30+/m0/s1

Synonyms: N-[6-(2-Cyanoethoxy)-9-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-9H-purin-2-yl]-2-methylpropanamide; N-(9-((2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl)-6-(2-isocyanoethoxy)-9H-purin-2-yl)isobutyramide; N-{9-[(2R,6S)-6-(Hydroxymethyl)-4-trityl-2-morpholinyl]-6-(2-isocyanoethoxy)-9H-purin-2-yl}-2-methylpropanamide