What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

Alkyne-Trebler Phosphoramidite

Description: Alkyne-Trebler Phosphoramidite is a branching reagent used in oligonucleotide synthesis. It contains a phosphoramidite moiety with a trebler alkyne structure, enabling the introduction of multiple alkyne sites within an oligonucleotide chain. The trebler alkyne architecture facilitates trifurcate branching and subsequent bioorthogonal click chemistry modifications, allowing the synthesis of multivalent or highly functionalized oligonucleotides.

CAT: BRP-02865

CAS: 2135330-70-8

Molecular Formula: C35H59N2O9P

Molecular Weight: 682.84

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InChIKey: IGEUVARIUHWSDG-UHFFFAOYSA-N

SMILES: N#CCCOP(OCCCOCC(COCCCOCC#C)(COCCCOCC#C)COCCCOCC#C)N(C(C)C)C(C)C

InChI: InChI=1S/C35H59N2O9P/c1-8-17-38-20-12-23-41-29-35(30-42-24-13-21-39-18-9-2,31-43-25-14-22-40-19-10-3)32-44-26-15-28-46-47(45-27-11-16-36)37(33(4)5)34(6)7/h1-3,33-34H,11-15,17-32H2,4-7H3

Synonyms: 2-Cyanoethyl (3-(3-(3-(prop-2-yn-1-yloxy)propoxy)-2,2-bis((3-(prop-2-yn-1-yloxy)propoxy)methyl)propoxy)propyl) diisopropylphosphoramidite

Alkyne-Trebler Pro Phosphoramidite

Description: Alkyne-Trebler Pro Phosphoramidite is a branching reagent used in oligonucleotide synthesis. It contains a phosphoramidite moiety with a trebler alkyne structure attached to a hydroxyprolinol linker. The hydroxyprolinol provides a rigid, non-nucleosidic scaffold, while the trebler alkyne architecture facilitates trifurcate branching and subsequent bioorthogonal click chemistry modifications, allowing the synthesis of multivalent or highly functionalized oligonucleotides.

CAT: BRP-02866

CAS: 2223630-40-6

Molecular Formula: C64H90N3O14P

Molecular Weight: 1156.40

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InChIKey: MGNDTGJLARYRLB-TXOIWDNHSA-N

SMILES: C#CCOCCCOCC(COCCCOCC#C)(COCCCOCC#C)COCCCOCCC(N1C[C@@H](C[C@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)C4=CC=C(C=C4)OC)OP(N(C(C)C)C(C)C)OCCC#N)=O

InChI: InChI=1S/C64H90N3O14P/c1-10-33-71-36-17-40-75-49-63(50-76-41-18-37-72-34-11-2,51-77-42-19-38-73-35-12-3)52-78-43-20-39-74-45-31-62(68)66-47-61(81-82(80-44-16-32-65)67(53(4)5)54(6)7)46-58(66)48-79-64(55-21-14-13-15-22-55,56-23-27-59(69-8)28-24-56)57-25-29-60(70-9)30-26-57/h1-3,13-15,21-30,53-54,58,61H,16-20,31,33-52H2,4-9H3/t58-,61+,82?/m0/s1

Synonyms: (3R,5S)-1-(10,10-Bis((3-(prop-2-yn-1-yloxy)propoxy)methyl)-4,8,12,16-tetraoxanonadec-18-ynoyl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)pyrrolidin-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Alkyne-Trebler Phosphoramidite (hydroxyprolinol)

BCN Phosphoramidite ACH

Description: BCN Phosphoramidite ACH is a copper-free click chemistry reagent used in oligonucleotide synthesis. It contains a bicyclo[6.1.0]nonyne (BCN) functional group attached to a phosphoramidite moiety with an ACH (aminocyclohexanol) linker. The ACH linker provides a rigid scaffold, while the BCN group enables highly efficient and completely orthogonal bioconjugation with various azide molecules via strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalyst, allowing bioorthogonal modification of oligonucleotides under mild conditions.

CAT: BRP-02867

Molecular Formula: C26H42N3O4P

Molecular Weight: 491.61

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InChIKey: WJLQZGOGPRHKDO-YQNCDECVSA-N

SMILES: CC(N(P(OC(CC1)CCC1NC(OC[C@@H]2[C@@]3([H])CCC#CCC[C@@]23[H])=O)OCCC#N)C(C)C)C

InChI: InChI=1S/C26H42N3O4P/c1-19(2)29(20(3)4)34(32-17-9-16-27)33-22-14-12-21(13-15-22)28-26(30)31-18-25-23-10-7-5-6-8-11-24(23)25/h19-25H,7-15,17-18H2,1-4H3,(H,28,30)/t21?,22?,23-,24+,25+,34?

Synonyms: ((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)cyclohexyl)carbamate; BCN cyclohexyl Phosphoramidite

BCN Pro Phosphoramidite

Description: BCN Pro Phosphoramidite is a copper-free click chemistry reagent used in oligonucleotide synthesis. It contains a bicyclo[6.1.0]nonyne (BCN) functional group attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold. The BCN group enables highly efficient and completely orthogonal bioconjugation with various azide molecules via strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalyst, allowing bioorthogonal modification of oligonucleotides under mild conditions.

CAT: BRP-02868

Molecular Formula: C52H69N4O8P

Molecular Weight: 909.12

Purity: ≥98%

Appearance: White foam

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Storage: Store at -20 °C

InChIKey: GZJMCSNKUWQHKK-NRJIPUSRSA-N

SMILES: CC(N(C(C)C)P(O[C@H]1CN(C(CCCCCNC(OC[C@H]2[C@]3([C@@]2(CCC#CCC3)[H])[H])=O)=O)[C@H](COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)C1)OCCC#N)C

InChI: InChI=1S/C52H69N4O8P/c1-38(2)56(39(3)4)65(63-33-17-31-53)64-46-34-43(55(35-46)50(57)22-15-10-16-32-54-51(58)61-37-49-47-20-13-7-8-14-21-48(47)49)36-62-52(40-18-11-9-12-19-40,41-23-27-44(59-5)28-24-41)42-25-29-45(60-6)30-26-42/h9,11-12,18-19,23-30,38-39,43,46-49H,10,13-17,20-22,32-37H2,1-6H3,(H,54,58)/t43-,46+,47-,48+,49+,65?/m0/s1

Synonyms: BCN Phosphoramidite (hydroxyprolinol); ((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (6-((2S,4R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamate; ((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (6-((2S,4R)-2-(4,4'-dimethoxytrityloxymethyl)-4-hydroxypyrrolidin-1-yl)-6-oxohexyl)carbamate 2-cyanoethyl N,N-diisopropylphosphoramidite

BCN (R)-Glycerol Phosphoramidite

Description: BCN (R)-Glycerol Phosphoramidite is a copper-free click chemistry reagent used in oligonucleotide synthesis. It contains a bicyclo[6.1.0]nonyne (BCN) functional group attached to a phosphoramidite moiety via an (R)-glycerol linker. The (R)-glycerol linker provides a chiral, hydrophilic scaffold, while the BCN group enables highly efficient and completely orthogonal bioconjugation with various azide molecules via strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalyst, allowing bioorthogonal modification of oligonucleotides under mild conditions.

CAT: BRP-02869

Molecular Formula: C53H74N3O11P

Molecular Weight: 960.16

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InChIKey: OXGJDLMEDKZGOC-VJTXMCHVSA-N

SMILES: CC(N(P(O[C@H](COCCOCCOCCOCCCNC(OC[C@@H]1[C@@]2([C@]1(CCC#CCC2)[H])[H])=O)COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)OCCC#N)C(C)C)C

InChI: InChI=1S/C53H74N3O11P/c1-41(2)56(42(3)4)68(66-31-14-28-54)67-48(39-65-53(43-16-10-9-11-17-43,44-20-24-46(58-5)25-21-44)45-22-26-47(59-6)27-23-45)38-63-37-36-62-35-34-61-33-32-60-30-15-29-55-52(57)64-40-51-49-18-12-7-8-13-19-50(49)51/h9-11,16-17,20-27,41-42,48-51H,12-15,18-19,29-40H2,1-6H3,(H,55,57)/t48-,49-,50+,51+,68?/m1/s1

Synonyms: BCN TEG (DMT) (R)-Glycerol Phosphoramidite; BCN TEG (DMT) Phosphoramidite (R); ((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((4R)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-1,1-bis(4-methoxyphenyl)-1-phenyl-2,6,9,12,15-pentaoxaoctadecan-18-yl)carbamate

Biotin Pro Phosphoramidite

Description: Biotin Pro Phosphoramidite is a non-fluorescent modifier used in oligonucleotide synthesis. It contains a biotin moiety attached to a hydroxyprolinol-based phosphoramidite. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of biotin at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. Biotin enables high-affinity binding to streptavidin or avidin, facilitating oligonucleotide purification, detection, and immobilization applications.

CAT: BRP-02870

CAS: 2918763-05-8

Molecular Formula: C51H71N6O8PS

Molecular Weight: 959.18

Purity: 95%

Appearance: White powder

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Storage: Store at -20 °C

Boiling Point: 1014.2±65.0 °C at 760 mmHg

InChIKey: VQUIJKLBAJXSJQ-PDACXQFNSA-N

Solubility: Soluble in Acetonitrile, DCM, THF

SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1C[C@H](N(C1)C(=O)CCCCCNC(=O)CCCC[C@H]2[C@@H]3[C@H](CS2)NC(=O)N3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[6-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypyrrolidin-1-yl]-6-oxohexyl]pentanamide

InChI: InChI=1S/C51H71N6O8PS/c1-36(2)57(37(3)4)66(64-31-15-29-52)65-44-32-41(34-63-51(38-16-9-7-10-17-38,39-21-25-42(61-5)26-22-39)40-23-27-43(62-6)28-24-40)56(33-44)48(59)20-11-8-14-30-53-47(58)19-13-12-18-46-49-45(35-67-46)54-50(60)55-49/h7,9-10,16-17,21-28,36-37,41,44-46,49H,8,11-15,18-20,30-35H2,1-6H3,(H,53,58)(H2,54,55,60)/t41-,44+,45-,46-,49-,66?/m0/s1

Synonyms: Biotin phosphoramidite (hydroxyprolinol); (3R,5S)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-1-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanoyl)pyrrolidin-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxohexyl]-3-pyrrolidinyl 2-cyanoethyl ester; (3R,5S)-5-{[Bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-1-[6-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoyl]-3-pyrrolidinyl 2-cyanoethyl diisopropylphosphoramidite

Cholesterol Pro Phosphoramidite

Description: Cholesterol Pro Phosphoramidite is a non-fluorescent modifier used in oligonucleotide synthesis. It contains a cholesterol moiety attached to a hydroxyprolinol-based phosphoramidite. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of cholesterol at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. Cholesterol conjugation enhances cellular uptake, improves nuclease resistance, and facilitates in vivo delivery of oligonucleotides.

CAT: BRP-02871

CAS: 851912-63-5

Molecular Formula: C69H101N4O8P

Molecular Weight: 1145.56

Purity: ≥99% by NMR

Appearance: White foam

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InChIKey: OQAXECQSIWYVJG-NTMKDRLQSA-N

SMILES: CC(N(P(O[C@@H](CN1C(CCCCCNC(O[C@H]2CC[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]5([H])[C@]4([H])CC=C3C2)=O)=O)C[C@H]1COC(C6=CC=C(C=C6)OC)(C7=CC=CC=C7)C8=CC=C(C=C8)OC)OCCC#N)C(C)C)C

InChI: InChI=1S/C69H101N4O8P/c1-48(2)20-18-21-51(7)62-35-36-63-61-34-29-55-44-59(37-39-67(55,8)64(61)38-40-68(62,63)9)80-66(75)71-42-17-13-16-24-65(74)72-46-60(81-82(79-43-19-41-70)73(49(3)4)50(5)6)45-56(72)47-78-69(52-22-14-12-15-23-52,53-25-30-57(76-10)31-26-53)54-27-32-58(77-11)33-28-54/h12,14-15,22-23,25-33,48-51,56,59-64H,13,16-21,24,34-40,42-47H2,1-11H3,(H,71,75)/t51-,56+,59+,60-,61+,62-,63+,64+,67+,68-,82?/m1/s1

Synonyms: (3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (6-((2S,4R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamate; Cholesterol Phosphoramidite (hydroxyprolinol); (1S,2R,5S,10S,11S,14R,15R)-2,15-Dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.02,7.011,15]heptadec-7-en-5-yl N-{6-[(2S,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-({[bis(propan-2-yl)amino](2-cyanoethoxy)phosphanyl}oxy)pyrrolidin-1-yl]-6-oxohexyl}carbamate

Cholesterol TEG (DMT) Phosphoramidite (R)

Description: Cholesterol TEG (DMT) Phosphoramidite (R) is a non-fluorescent modifier used in oligonucleotide synthesis. It contains a cholesterol moiety attached to a phosphoramidite via a triethylene glycol (TEG) linker, with a dimethoxytrityl (DMT) protecting group, on an (R)-glycerol backbone. The TEG linker provides flexibility and hydrophilicity, while the DMT group enables standard trityl-on purification. Cholesterol conjugation enhances cellular uptake, improves nuclease resistance, and facilitates in vivo delivery of oligonucleotides.

CAT: BRP-02872

CAS: 1799625-61-8

Molecular Formula: C70H106N3O11P

Molecular Weight: 1196.60

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InChIKey: FNJSTUYYFCEZCA-UDWAMZCPSA-N

SMILES: O=C(O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@@H](CCCC(C)C)C)CC[C@@]4([H])[C@]3([H])CC=C2C1)NCCCOCCOCCOCCOC[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)COC(C5=CC=C(OC)C=C5)(C6=CC=C(OC)C=C6)C7=CC=CC=C7

InChI: InChI=1S/C70H106N3O11P/c1-51(2)18-15-19-54(7)64-32-33-65-63-31-26-58-48-61(34-36-68(58,8)66(63)35-37-69(64,65)9)83-67(74)72-39-17-40-77-42-43-78-44-45-79-46-47-80-49-62(84-85(82-41-16-38-71)73(52(3)4)53(5)6)50-81-70(55-20-13-12-14-21-55,56-22-27-59(75-10)28-23-56)57-24-29-60(76-11)30-25-57/h12-14,20-30,51-54,61-66H,15-19,31-37,39-50H2,1-11H3,(H,72,74)/t54-,61+,62-,63+,64-,65+,66+,68+,69-,85?/m1/s1

Synonyms: 1-Dimethoxytrityloxy-3-O-(N-cholesteryl-3-aminopropyl)-triethyleneglycol-(R)-glyceryl-2-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Cholesteryl TEG phosphoramidite (R); Dimethoxytrityloxy-3-O-(N-cholesteryl-3-aminopropyl)triethyleneglycol-(R)-glyceryl-2-O-(2-cyanoethyl)(N,N-diisopropyl)phosphoramidite; DMTr-Cholesteryl-TEG Phosphoramidite (R); 1-O-(4,4'-dimethoxytrityl)-3-O-(N-cholesteryl-3-aminopropyl)-triethyleneglycol-(R)-glyceryl-2-O-(2-cyanoethyl)-(N,N-diisopropyl) Phosphoramidite; DMT-Cholesterol (Plant) TEG CE phosphoramidite (R); Cholesterol (R)-Glycerol Phosphoramidite; Cholesterol TEG (DMT) (R)-Glycerol Phosphoramidite; (3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ((4R)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-1,1-bis(4-methoxyphenyl)-1-phenyl-2,6,9,12,15-pentaoxaoctadecan-18-yl)carbamate

Related CAS: 873435-29-1 (Cholesterol TEG (DMT) Phosphoramidite)

Mono GalNAc TEG Phosphoramidite

Description: Mono GalNAc TEG Phosphoramidite is a non-fluorescent modifier used in oligonucleotide synthesis. It contains a monovalent N-acetylgalactosamine (GalNAc) moiety attached to a phosphoramidite via a triethylene glycol (TEG) linker. The TEG linker provides flexibility and hydrophilicity, while the GalNAc ligand enables high-affinity binding to the asialoglycoprotein receptor (ASGPR) on hepatocytes, facilitating targeted delivery of oligonucleotides to the liver.

CAT: BRP-02873

Molecular Formula: C62H90N3O19P

Molecular Weight: 1213.37

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InChIKey: ZBBIFTGXXMNXRH-OMZCFCQGSA-N

SMILES: O=C(N[C@H]([C@H]([C@@H]1OC(C)=O)OC(C)=O)[C@@H](O[C@@H]1COC(C)=O)OCCCCC(NCCCOCCOCCOCCOCC(COC(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)C4=CC=C(C=C4)OC)OP(N(C(C)C)C(C)C)OCCC#N)=O)C

InChI: InChI=1S/C61H89N4O19P/c1-43(2)65(44(3)4)85(80-33-16-29-62)84-54(41-79-61(49-18-12-11-13-19-49,50-21-25-52(71-9)26-22-50)51-23-27-53(72-10)28-24-51)40-76-39-38-75-37-36-74-35-34-73-31-17-30-63-56(70)20-14-15-32-77-60-57(64-45(5)66)59(82-48(8)69)58(81-47(7)68)55(83-60)42-78-46(6)67/h11-13,18-19,21-28,43-44,54-55,57-60H,14-17,20,30-42H2,1-10H3,(H,63,70)(H,64,66)/t54?,55-,57-,58-,59-,60-,85?/m1/s1

Synonyms: (2R,3S,4R,5R,6R)-5-Acetamido-2-(acetoxymethyl)-6-((4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-1,1-bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azatetracosan-24-yl)oxy)tetrahydro-2H-pyran-3,4-diyl diacetate; Mono GalNAc TEG (DMT) Phosphoramidite

TCO TEG Phosphoramidite

Description: TCO TEG Phosphoramidite is a click chemistry reagent used in oligonucleotide synthesis. It contains a trans-cyclooctene (TCO) functional group attached to a phosphoramidite via a triethylene glycol (TEG) linker. The TCO group enables highly efficient and rapid bioorthogonal inverse electron demand Diels-Alder (IEDDA) reactions with tetrazine-functionalized molecules, allowing selective labeling and bioconjugation of oligonucleotides under mild, copper-free conditions.

CAT: BRP-02874

Molecular Formula: C26H48N3O7P

Molecular Weight: 545.66

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Storage: Store at -20 °C

InChIKey: RFGSLOPZPOFQDG-SWTBTQGLSA-N

SMILES: N#CCCOP(N(C(C)C)C(C)C)OCCOCCOCCOCCNC(O[C@H]1CC/C=C/CCC1)=O

InChI: InChI=1S/C26H48N3O7P/c1-23(2)29(24(3)4)37(34-15-10-13-27)35-22-21-33-20-19-32-18-17-31-16-14-28-26(30)36-25-11-8-6-5-7-9-12-25/h5-6,23-25H,7-12,14-22H2,1-4H3,(H,28,30)/b6-5+/t25-,37?/m0/s1

Synonyms: (R,E)-Cyclooct-4-en-1-yl (2-(2-(2-(2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate

Amino-modifier Pro Phosphoramidite

Description: Amino-modifier Pro Phosphoramidite is a functional modification reagent used in oligonucleotide synthesis. It contains a trifluoroacetyl (TFA)-protected primary amine (—NH2) attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold, enabling efficient incorporation of the protected amino functionality at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. After deprotection, the free amino group can be used for subsequent conjugation with fluorescent dyes, biotin, or other active molecules, making it widely applied in oligonucleotide labeling, probe construction, and bioconjugation.

CAT: BRP-02899

CAS: 1644576-49-7

Molecular Formula: C43H56F3N4O7P

Molecular Weight: 828.90

Purity: ≥95%

Appearance: White foam

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Storage: Store at -20 °C

Boiling Point: 811.1±65.0 °C at 760 mmHg

InChIKey: ZPMINVQQJLABCL-DLPTWEIFSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1C[C@H](N(C1)C(=O)CCCCCNC(=O)C(F)(F)F)COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC

IUPAC Name: N-[6-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypyrrolidin-1-yl]-6-oxohexyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C43H56F3N4O7P/c1-31(2)50(32(3)4)58(56-27-13-25-47)57-39-28-36(49(29-39)40(51)16-11-8-12-26-48-41(52)43(44,45)46)30-55-42(33-14-9-7-10-15-33,34-17-21-37(53-5)22-18-34)35-19-23-38(54-6)24-20-35/h7,9-10,14-15,17-24,31-32,36,39H,8,11-13,16,26-30H2,1-6H3,(H,48,52)/t36-,39+,58?/m0/s1

Synonyms: (3R,5S)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-1-(6-(2,2,2-trifluoroacetamido)hexanoyl)pyrrolidin-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1-oxo-6-[(2,2,2-trifluoroacetyl)amino]hexyl]-3-pyrrolidinyl 2-cyanoethyl ester; Amino-modifier Phosphoramidite Pro; Amino-modifier Phosphoramidite (hydroxyprolinol)

Aminolinker-18 Phosphoramidite

Description: Aminolinker-18 Phosphoramidite is a non-fluorescent modifier used in oligonucleotide synthesis. It contains an 18-atom spacer arm composed of five PEG units with a terminal primary amine group protected by a monomethoxytrityl (MMT) group, attached to a phosphoramidite moiety. The MMT group is selectively removed under mild acidic conditions to expose the amine for post-synthetic conjugation of various functional groups, fluorophores, quenchers, or biotin. It is commonly used for oligonucleotide labeling, surface immobilization, and bioconjugation applications.

CAT: BRP-02900

CAS: 688349-99-7

Molecular Formula: C41H60N3O8P

Molecular Weight: 753.92

Appearance: Colorless to yellowish viscous oily matter

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Storage: Store at -20 °C

Boiling Point: 746.9±60.0 °C at 760 mmHg

InChIKey: DPPYYVKOXPOYNB-UHFFFAOYSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCOCCOCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC

IUPAC Name: 3-[[di(propan-2-yl)amino]-[2-[2-[2-[2-[2-[2-[[(4-methoxyphenyl)-diphenylmethyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H60N3O8P/c1-35(2)44(36(3)4)53(51-23-12-21-42)52-34-33-50-32-31-49-30-29-48-28-27-47-26-25-46-24-22-43-41(37-13-8-6-9-14-37,38-15-10-7-11-16-38)39-17-19-40(45-5)20-18-39/h6-11,13-20,35-36,43H,12,22-34H2,1-5H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 19-(4-methoxyphenyl)-19,19-diphenyl-3,6,9,12,15-pentaoxa-18-azanonadec-1-yl ester; 2-Cyanoethyl (1-(4-methoxyphenyl)-1,1-diphenyl-5,8,11,14,17-pentaoxa-2-azanonadecan-19-yl) diisopropylphosphoramidite

S-Bz Thiol-Modifier Phosphoramidite ACH

Description: S-Bz Thiol-Modifier Phosphoramidite ACH is a non-fluorescent modifier used in oligonucleotide synthesis. It contains a benzoyl (Bz) protected thiol group attached to a phosphoramidite via an ACH (aminocyclohexanol) linker. The Bz protecting group is removed under basic conditions to expose the thiol for post-synthetic conjugation with maleimides, haloacetyls, or other thiol-reactive groups. It is commonly used for oligonucleotide labeling, crosslinking, and bioconjugation applications.

CAT: BRP-02901

Molecular Formula: C25H38N3O4PS

Molecular Weight: 507.63

Purity: >98%

Appearance: Pale yellow oily matter

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Storage: Store at -20 °C

InChIKey: PCYFKXWNTUTOLL-UHFFFAOYSA-N

SMILES: CC(N(P(OC(CC1)CCC1NC(CCSC(C2=CC=CC=C2)=O)=O)OCCC#N)C(C)C)C

InChI: InChI=1S/C25H38N3O4PS/c1-19(2)28(20(3)4)33(31-17-8-16-26)32-23-13-11-22(12-14-23)27-24(29)15-18-34-25(30)21-9-6-5-7-10-21/h5-7,9-10,19-20,22-23H,8,11-15,17-18H2,1-4H3,(H,27,29)

Synonyms: S-(3-((4-(((2-Cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)cyclohexyl)amino)-3-oxopropyl) benzothioate; S-Bz Thiol-Modifier cyclohexyl Phosphoramidite; Bz Thiol-Modifier Phosphoramidite ACH; S-(3-(((1r,4r)-4-(((2-Cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)cyclohexyl)amino)-3-oxopropyl)benzothioate

S-Bz Thiol-Modifier Pro Phosphoramidite

Description: S-Bz Thiol-Modifier Pro Phosphoramidite is a non-fluorescent modifier used in oligonucleotide synthesis. It contains a benzoyl (Bz) protected thiol group attached to a hydroxyprolinol-based phosphoramidite. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold. The Bz protecting group is removed under basic conditions to expose the thiol for post-synthetic conjugation with maleimides, haloacetyls, or other thiol-reactive groups. It is commonly used for oligonucleotide labeling, crosslinking, and bioconjugation applications.

CAT: BRP-02902

Molecular Formula: C51H65N4O8PS

Molecular Weight: 925.13

Purity: >99%

Appearance: White foam

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InChIKey: WZDLEQJOYWVGGG-OCZQXMSMSA-N

SMILES: O=C(CCSC(C1=CC=CC=C1)=O)NCCCCCC(N2C[C@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@H]2COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5)=O

InChI: InChI=1S/C51H65N4O8PS/c1-38(2)55(39(3)4)64(62-33-16-31-52)63-47-35-44(54(36-47)49(57)21-14-9-15-32-53-48(56)30-34-65-50(58)40-17-10-7-11-18-40)37-61-51(41-19-12-8-13-20-41,42-22-26-45(59-5)27-23-42)43-24-28-46(60-6)29-25-43/h7-8,10-13,17-20,22-29,38-39,44,47H,9,14-16,21,30,32-37H2,1-6H3,(H,53,56)/t44-,47+,64?/m0/s1

Synonyms: S-(3-((6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)amino)-3-oxopropyl) benzothioate; S-(3-((6-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxypyrrolidin-1-yl)-6-oxohexyl)amino)-3-oxopropyl)benzothioate 2-cyanoethyl N,N-diisopropylphosphoramidite; S-Bz Thiol-Modifier Phosphoramidite (hydroxyprolinol)

Glycerol TEG Doubler Phosphoramidite

Description: Glycerol TEG Doubler Phosphoramidite is a branching reagent used in oligonucleotide synthesis. It enables bifurcate branching with two dimethoxytrityl (DMT) protecting groups for standard trityl-on purification, allowing the synthesis of multivalent oligonucleotides with enhanced functional group density. The triethylene glycol (TEG) linker provides flexibility and hydrophilicity, facilitating applications in targeted delivery, bioconjugation, and advanced therapeutic oligonucleotide design.

CAT: BRP-02903

Molecular Formula: C62H77N2O12P

Molecular Weight: 1073.27

Purity: >94%

Appearance: Colorless to yellowish viscous oily matter

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InChIKey: RHOSSFWJRZJPNN-ZFSQMOOASA-N

SMILES: COC(C=C1)=CC=C1C(C2=CC=CC=C2)(OC[C@@H](COCCOCCOCCOCCOC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)OP(N(C(C)C)C(C)C)OCCC#N)C6=CC=C(C=C6)OC

InChI: InChI=1S/C62H77N2O12P/c1-48(2)64(49(3)4)77(75-37-15-36-63)76-60(47-74-62(51-18-13-10-14-19-51,54-24-32-58(67-7)33-25-54)55-26-34-59(68-8)35-27-55)46-72-43-42-70-39-38-69-40-41-71-44-45-73-61(50-16-11-9-12-17-50,52-20-28-56(65-5)29-21-52)53-22-30-57(66-6)31-23-53/h9-14,16-35,48-49,60H,15,37-47H2,1-8H3/t60-,77?/m1/s1

Synonyms: 2-Cyanoethyl ((R)-1,1,19,19-tetrakis(4-methoxyphenyl)-1,19-diphenyl-2,5,8,11,14,18-hexaoxanonadecan-16-yl) diisopropylphosphoramidite; Glycerol TEG (DMT) Doubler Phosphoramidite

Ferrocenyl Pro Phosphoramidite

Description: Ferrocenyl Pro Phosphoramidite is a non-fluorescent modifier used in oligonucleotide synthesis. It contains a ferrocene moiety attached to a hydroxyprolinol-based phosphoramidite. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold for efficient incorporation of the ferrocene label at the 5' end of DNA or RNA sequences during automated solid-phase synthesis. The ferrocene group enables electrochemical detection, redox-active sensing, and electron transfer studies of modified oligonucleotides.

CAT: BRP-02904

Molecular Formula: C52H65FeN4O7P

Molecular Weight: 944.93