Phosphoramidites

[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-uridine (2'-OMe-U), a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, and another 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01514

Molecular Formula: C82H91N16O23P3

Molecular Weight: 1761.64

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20 °C

InChIKey: HDBXZWVSPSMPEB-YNFWSCMJSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C82H91N16O23P3/c1-51(2)98(52(3)4)122(111-41-19-37-83)119-66-61(117-79(69(66)107-7)96-49-90-64-72(86-47-88-74(64)96)93-76(100)53-22-13-10-14-23-53)45-114-123(103,112-42-20-38-84)121-68-62(118-80(71(68)109-9)97-50-91-65-73(87-48-89-75(65)97)94-77(101)54-24-15-11-16-25-54)46-115-124(104,113-43-21-39-85)120-67-60(116-78(70(67)108-8)95-40-36-63(99)92-81(95)102)44-110-82(55-26-17-12-18-27-55,56-28-32-58(105-5)33-29-56)57-30-34-59(106-6)35-31-57/h10-18,22-36,40,47-52,60-62,66-71,78-80H,19-21,41-46H2,1-9H3,(H,92,99,102)(H,86,88,93,100)(H,87,89,94,101)/t60-,61-,62-,66-,67-,68-,69-,70-,71-,78-,79-,80-,122?,123?,124?/m1/s1

Synonyms: UmAmAm; [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-OMe-dA(Bz)](pCyEt)[2'-OMe-dA(Bz)-3'-CE_x005f_x0002_Phosphoramidite]

DMTr-O Diethyleneglycol Phosphoramidite

Description: DMTr-O Diethyleneglycol Phosphoramidite is a phosphoramidite reagent used in solid-phase oligonucleotide synthesis. This phosphoramidite facilitates the efficient and controlled synthesis of oligonucleotides with high purity. The bulky protecting groups on the backbone provide stability during synthesis and can be selectively removed during deprotection steps. This reagent is commonly used in automated oligonucleotide synthesis for various molecular biology and biotechnology applications.

CAT: BRP-01515

CAS: 362013-57-8

Molecular Formula: C34H45N2O6P

Molecular Weight: 608.72

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InChIKey: VTWDQGJYTBUVCR-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCOCCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 2-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethoxy)ethyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C34H45N2O6P/c1-27(2)36(28(3)4)43(41-22-10-21-35)42-26-24-39-23-25-40-34(29-11-8-7-9-12-29,30-13-17-32(37-5)18-14-30)31-15-19-33(38-6)20-16-31/h7-9,11-20,27-28H,10,22-26H2,1-6H3

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 2-[2-[bis(4-methoxyphenyl)phenylmethoxy]ethoxy]ethyl 2-cyanoethyl ester

5'-Cholesterol PEG5-CE Phosphoramidite

Description: 5'-Cholesterol PEG5-CE Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce a cholesterol moiety and a PEG (polyethylene glycol) spacer at the 5' end of the oligonucleotide. This modification enhances the stability, solubility, and cellular uptake of the oligonucleotide, making it useful for various applications such as antisense therapy, siRNA, and molecular probes.

CAT: BRP-01516

Molecular Formula: C46H83N2O7P

Molecular Weight: 807.15

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InChIKey: ZYJFPTPFCJYMIF-GNUFTJHZSA-N

IUPAC Name: 2-cyanoethyl (14-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-3,6,9,12-tetraoxatetradecyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H83N2O7P/c1-35(2)12-10-13-38(7)42-16-17-43-41-15-14-39-34-40(18-20-45(39,8)44(41)19-21-46(42,43)9)53-32-30-51-28-26-49-24-25-50-27-29-52-31-33-55-56(54-23-11-22-47)48(36(3)4)37(5)6/h14,35-38,40-44H,10-13,15-21,23-34H2,1-9H3/t38-,40+,41+,42-,43+,44+,45+,46-,56?/m1/s1

5'-Biotin Phosphoramidite

Description: 5'-Biotin Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce a biotin molecule at the 5' end of the oligonucleotide. Introducing biotin at the 5' end allows for easy conjugation of the oligonucleotide to streptavidin or avidin, enabling applications like DNA/RNA labeling, pull-down assays, detection of nucleic acid hybridization, and immobilization of oligonucleotides onto solid supports.

CAT: BRP-01517

CAS: 1807503-79-2

Molecular Formula: C46H64N5O6PS

Molecular Weight: 846.08

Purity: ≥95%

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InChIKey: RBXYKQBFPLXSJS-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)CCCCC1C2C(CS1)N(C(=O)N2)C(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OCCC#N

IUPAC Name: 5-[3-[bis(4-methoxyphenyl)-phenylmethyl]-2-oxo-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl]-N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]pentanamide

InChI: InChI=1S/C46H64N5O6PS/c1-34(2)51(35(3)4)58(57-32-16-29-47)56-31-15-8-7-14-30-48-43(52)20-13-12-19-42-44-41(33-59-42)50(45(53)49-44)46(36-17-10-9-11-18-36,37-21-25-39(54-5)26-22-37)38-23-27-40(55-6)28-24-38/h9-11,17-18,21-28,34-35,41-42,44H,7-8,12-16,19-20,30-33H2,1-6H3,(H,48,52)(H,49,53)

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 6-[[5-[1-[bis(4-methoxyphenyl)phenylmethyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl ester; 6-(5-(1-(Bis(4-methoxyphenyl)(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexyl (2-cyanoethyl) diisopropylphosphoramidite

ICG-NHS

Description: ICG-NHS is synthesized by conjugating NHS to the carboxyl group of ICG, creating an activated ester. This NHS-activated ICG can then react specifically with primary amines on molecules like proteins, peptides, or oligonucleotides to form stable amide bonds. ICG-NHS conjugates are commonly used for labeling biomolecules for imaging, targeting, or drug delivery purposes in biological research and medical diagnostics.

CAT: BRP-01518

CAS: 1622335-40-3

Molecular Formula: C49H53N3O7S

Molecular Weight: 828.03

Purity: ≥95%

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InChIKey: KDJUNNVUQBKNAY-UHFFFAOYSA-N

CanonicalSMILES: CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)CCCCCC(=O)ON4C(=O)CCC4=O)C=CC=CC=CC=C5C(C6=C(N5CCCCS(=O)(=O)[O-])C=CC7=CC=CC=C76)(C)C)C

IUPAC Name: 4-[2-[7-[3-[6-(2,5-dioxopyrrolidin-1-yl)oxy-6-oxohexyl]-1,1-dimethylbenzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate

InChI: InChI=1S/C49H53N3O7S/c1-48(2)41(50(39-28-26-35-19-12-14-21-37(35)46(39)48)32-16-8-11-25-45(55)59-52-43(53)30-31-44(52)54)23-9-6-5-7-10-24-42-49(3,4)47-38-22-15-13-20-36(38)27-29-40(47)51(42)33-17-18-34-60(56,57)58/h5-7,9-10,12-15,19-24,26-29H,8,11,16-18,25,30-34H2,1-4H3

Synonyms: 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-3-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-1,1-dimethyl-, inner salt; Indocyanine Green-NHS; 4-(2-(7-(3-(6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-2-yl)hepta-2,4,6-trien-1-ylidene)-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)butane-1-sulfonate; ICG-OSu; ICG NHS ester; ICG-NHS(mono-sulfo-cy7.5 NHS)

12-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxypyrrolidin-1-yl)-12-oxododecanoic acid

Description: 12-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxypyrrolidin-1-yl)-12-oxododecanoic acid is a chemically modified carbohydrate derivative. The peracetylation enhances its stability and lipophilicity, while the GalNAc moiety facilitates specific biological interactions, often used in targeted drug delivery systems. The L96-Acid acts as a linker to connect GalNAc to other functional groups or molecules, and the TEA salt ensures solubility and stability in solution. This compound is useful in pharmaceutical and biochemical applications, particularly in the development of targeted therapeutics and diagnostic agents.

CAT: BRP-01519

CAS: 1159408-70-4

Molecular Formula: C38H49NO7

Molecular Weight: 631.81

Purity: ≥95%

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Density: 1.154±0.06 g/cm3

Boiling Point: 779.4±60.0 °C at 760 mmHg

InChIKey: CEYLTMDXADTBEL-JHOUSYSJSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4CC(CN4C(=O)CCCCCCCCCCC(=O)O)O

IUPAC Name: 12-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxypyrrolidin-1-yl]-12-oxododecanoic acid

InChI: InChI=1S/C38H49NO7/c1-44-34-22-18-30(19-23-34)38(29-14-10-9-11-15-29,31-20-24-35(45-2)25-21-31)46-28-32-26-33(40)27-39(32)36(41)16-12-7-5-3-4-6-8-13-17-37(42)43/h9-11,14-15,18-25,32-33,40H,3-8,12-13,16-17,26-28H2,1-2H3,(H,42,43)/t32-,33+/m0/s1

Synonyms: 1-Pyrrolidinedodecanoic acid, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-, (2S,4R)-; (2S,4R)-2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-1-pyrrolidinedodecanoic acid; Peracetylated GalNAc-L96-Acid-2

5'-DMT-PseudoUridine-CE-Phosphoramidite

Description: 5'-DMT-PseudoUridine-CE-Phosphoramidite is a phosphoramidite used in the chemical synthesis of oligonucleotides. This compound features a 5'-dimethoxytrityl (DMT) protecting group and a cyanoethyl (CE) phosphoramidite moiety, making it compatible with automated DNA/RNA synthesis protocols. Incorporating pseudouridine into synthetic RNA strands using this phosphoramidite is particularly valuable for research into RNA modifications, as pseudouridine can influence RNA stability, folding, and function. This tool aids in the development of RNA-based therapeutics and the study of RNA biology, enabling detailed exploration of pseudouridine's role in various cellular processes.

CAT: BRP-01520

CAS: 1244969-51-4

Molecular Formula: C39H47N4O9P

Molecular Weight: 746.79

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InChIKey: OMNBXPQZUMXZPM-LWYRIDHVSA-N

CanonicalSMILES: N#CCCOP(OC1C(O)C(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C5=CNC(=O)NC5=O)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-hydroxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C39H47N4O9P/c1-25(2)43(26(3)4)53(50-22-10-21-40)52-36-33(51-35(34(36)44)32-23-41-38(46)42-37(32)45)24-49-39(27-11-8-7-9-12-27,28-13-17-30(47-5)18-14-28)29-15-19-31(48-6)20-16-29/h7-9,11-20,23,25-26,33-36,44H,10,22,24H2,1-6H3,(H2,41,42,45,46)/t33-,34+,35+,36-,53?/m1/s1

Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-ribofuranosyl]-; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione; 5'-DMT-PseudoUridine 3'-CE-Phosphoramidite

5'-ODMT cEt G Phosphoramidite (Amidite)

Description: 5'-ODMT cEt G Phosphoramidite is a specialized chemical reagent used in the synthesis of oligonucleotides. This compound features a guanosine (G) base modified with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protecting group and a constrained ethyl (cEt) modification. The constrained ethyl (cEt) modification is designed to enhance the stability and binding affinity of the oligonucleotide, making it more resistant to nuclease degradation and improving its hybridization properties. This modification is particularly useful in the development of therapeutic oligonucleotides, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and other nucleic acid-based drugs.

CAT: BRP-01526

CAS: 945628-66-0

Molecular Formula: C46H56N7O9P

Molecular Weight: 881.95

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: VMDSRWMHPUGGSZ-KHGLYSIJSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=NC4=C3N=C(NC4=O)NC(=O)C(C)C)OP(N(C(C)C)C(C)C)OCCC#N)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C46H56N7O9P/c1-28(2)41(54)50-44-49-40-37(42(55)51-44)48-27-52(40)43-38-39(62-63(59-25-13-24-47)53(29(3)4)30(5)6)45(61-43,31(7)60-38)26-58-46(32-14-11-10-12-15-32,33-16-20-35(56-8)21-17-33)34-18-22-36(57-9)23-19-34/h10-12,14-23,27-31,38-39,43H,13,25-26H2,1-9H3,(H2,49,50,51,54,55)/t31-,38+,39-,43+,45-,63?/m0/s1

Synonyms: N2-ibu-G-(S)-cEt-Phosphoramidite; 5'-ODMT cEt G Phosphoramidite; S-cEt-G phosphoramidite; (1S,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite; N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methylpropanamide; S-cEt-G(iBu) phosphoramidite; CET-rG(ibu) Phosphoramidite; S-cEt-G(iBu)-CE-Phosphoramidite

5'-ODMT cEt m5U Phosphoramidite (Amidite)

Description: 5'-ODMT cEt m5U Phosphoramidite (Amidite) is a specialized chemical reagent used in the synthesis of oligonucleotides. This compound features a modified uridine (m5U) base, where the uridine is methylated at the 5-position, and includes a constrained ethyl (cEt) modification. Additionally, the 5' hydroxyl group is protected by a 4,4'-dimethoxytrityl (DMT) group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the oligonucleotide, making it more resistant to nuclease degradation and improving its hybridization properties. The methylation at the 5-position of uridine (m5U) is known to influence the binding affinity and specificity of the oligonucleotide to its target. This phosphoramidite is particularly useful in the development of therapeutic oligonucleotides, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and other nucleic acid-based drugs, where enhanced stability and binding affinity are crucial for efficacy.

CAT: BRP-01527

CAS: 1197033-22-9

Molecular Formula: C42H51N4O9P

Molecular Weight: 786.86

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: SEFBXGXPINACNI-IMMRMUFKSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=C(C(=O)NC3=O)C)OP(N(C(C)C)C(C)C)OCCC#N)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-methyl-3-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H51N4O9P/c1-27(2)46(28(3)4)56(52-24-12-23-43)55-37-36-39(45-25-29(5)38(47)44-40(45)48)54-41(37,30(6)53-36)26-51-42(31-13-10-9-11-14-31,32-15-19-34(49-7)20-16-32)33-17-21-35(50-8)22-18-33/h9-11,13-22,25,27-28,30,36-37,39H,12,24,26H2,1-8H3,(H,44,47,48)/t30-,36+,37-,39+,41-,56?/m0/s1

Synonyms: 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 5'-ODMT cEt m5U Phosphoramidite; S-cEt-m5U phosphoramidite; CET-m5U Phosphoramidite; S-cEt-m5U-CE-Phosphoramidite; S-cEt-T phosphoramidite; CET-5-Me-U Phosphoramidite; S-cEt-T-CE-Phosphoramidite

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)

Description: 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a specialized reagent used in the chemical synthesis of oligonucleotides. This compound features an adenine (A) base with an N6-benzoyl (N-Bz) protection and a constrained ethyl (cEt) modification, along with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protecting group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the oligonucleotide. This modification increases resistance to nuclease degradation and improves hybridization properties, making the resulting oligonucleotide more effective for various applications, including therapeutic uses. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is an important reagent for the synthesis of modified oligonucleotides, offering enhanced stability, binding affinity, and efficacy. It is particularly useful in the development of therapeutic oligonucleotides and other advanced nucleic acid-based research applications.

CAT: BRP-01528

CAS: 1197033-19-4

Molecular Formula: C49H54N7O8P

Molecular Weight: 899.97

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: XHEVZGBLRSIPCO-DZGFXGBPSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=NC4=C(N=CN=C43)NC(=O)C5=CC=CC=C5)OP(N(C(C)C)C(C)C)OCCC#N)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC

InChI: InChI=1S/C49H54N7O8P/c1-32(2)56(33(3)4)65(61-28-14-27-50)64-43-42-47(55-31-53-41-44(51-30-52-45(41)55)54-46(57)35-15-10-8-11-16-35)63-48(43,34(5)62-42)29-60-49(36-17-12-9-13-18-36,37-19-23-39(58-6)24-20-37)38-21-25-40(59-7)26-22-38/h8-13,15-26,30-34,42-43,47H,14,28-29H2,1-7H3,(H,51,52,54,57)/t34-,42+,43-,47+,48-,65?/m0/s1

Synonyms: S-cEt-A phosphoramidite; 5'-ODMT cEt N-Bz A Phosphoramidite; 5'-ODMT cEt A(Bz) Phosphoramidite; N6-Bz-2'-O-4'-A-Locked-Ar-CET-Phosphoramidite; CET-A(Bz) Phosphoramidite; 5'-ODMT cEt N-Bz A Phosphoramidite Amidite; S-cEt-A(Bz)-CE-Phosphoramidite; N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-9H-purin-6-yl]benzamide

5'-ODMT cEt U Phosphoramidite (Amidite)

Description: 5'-ODMT cEt U Phosphoramidite (Amidite) is a specialized chemical reagent used in the synthesis of oligonucleotides. This compound features a uridine (U) base modified with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protecting group and a constrained ethyl (cEt) modification. The constrained ethyl (cEt) modification is designed to enhance the stability and binding affinity of the oligonucleotide. This modification makes the oligonucleotide more resistant to nuclease degradation and improves its hybridization properties. The use of such modifications is particularly important in the development of therapeutic oligonucleotides, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and other nucleic acid-based drugs, where stability and binding affinity are crucial for efficacy.

CAT: BRP-01529

CAS: 945628-51-3

Molecular Formula: C41H49N4O9P

Molecular Weight: 772.82

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: MCMVDDGYNXOEJR-ZDHUYCFVSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=CC(=O)NC3=O)OP(N(C(C)C)C(C)C)OCCC#N)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(2,4-dioxopyrimidin-1-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H49N4O9P/c1-27(2)45(28(3)4)55(51-25-11-23-42)54-37-36-38(44-24-22-35(46)43-39(44)47)53-40(37,29(5)52-36)26-50-41(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-22,24,27-29,36-38H,11,25-26H2,1-7H3,(H,43,46,47)/t29-,36+,37-,38+,40-,55?/m0/s1

Synonyms: U-(S)-cEt-Phosphoramidite; 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-2,4(1H,3H)-pyrimidinedione; 5'-ODMT cEt U Phosphoramidite; S-cEt-U phosphoramidite; CET-U Phosphoramidite; S-cEt-U-CE-Phosphoramidite; cEt U Amidite

5'-ODMT cEt N-Bz C Phosphoramidite (Amidite)

Description: 5'-ODMT cEt N-Bz C Phosphoramidite (Amidite) is a specialized chemical reagent used in the synthesis of modified oligonucleotides. This compound features a cytosine (C) base with an N4-benzoyl (N-Bz) protecting group and a constrained ethyl (cEt) modification, along with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protective group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the resulting oligonucleotide. This modification increases resistance to nuclease degradation and improves hybridization properties, which is crucial for various research and therapeutic applications. 5'-ODMT cEt N-Bz C Phosphoramidite (Amidite) is an essential reagent for synthesizing modified oligonucleotides, providing enhanced stability, binding affinity, and resistance to degradation, particularly useful in developing advanced nucleic acid-based therapeutics and research tools.

CAT: BRP-01530

CAS: 945628-57-9

Molecular Formula: C48H54N5O9P

Molecular Weight: 875.94

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: QLEUKMYYYZVVED-INXIQYKVSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=CC(=NC3=O)NC(=O)C4=CC=CC=C4)OP(N(C(C)C)C(C)C)OCCC#N)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[1-[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C48H54N5O9P/c1-32(2)53(33(3)4)63(59-30-14-28-49)62-43-42-45(52-29-27-41(51-46(52)55)50-44(54)35-15-10-8-11-16-35)61-47(43,34(5)60-42)31-58-48(36-17-12-9-13-18-36,37-19-23-39(56-6)24-20-37)38-21-25-40(57-7)26-22-38/h8-13,15-27,29,32-34,42-43,45H,14,30-31H2,1-7H3,(H,50,51,54,55)/t34-,42+,43-,45+,47-,63?/m0/s1

Synonyms: S-cEt-C phosphoramidite; 5'-ODMT cEt N-Bz C Phosphoramidite; 5'-ODMT cEt C(Bz) Phosphoramidite; N4-Bz-2'-O-4'-A-Locked-Cr-CET-Phosphoramidite; CET-C(Bz) Phosphoramidite; 5'-ODMT cEt N-Bz C Phosphoramidite Amidite; S-cEt-C(Bz)-CE-Phosphoramidite; N-[1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]benzamide

5-VIC CE Phosphoramidite

Description: 5-VIC CE Phosphoramidite is a fluorescent phosphoramidite derivative designed for solid-phase oligonucleotide synthesis, enabling site-specific incorporation of the VIC dye (a xanthene-based fluorophore) at the 5'-terminus of oligonucleotides. VIC emits in the green-yellow spectrum with an excitation maximum at 526 nm and emission at 543 nm, making it suitable for real-time PCR (qPCR), hybridization assays, and fluorescence-based genetic analysis.

CAT: BRP-01539

Molecular Formula: C52H59Cl3N3O10P

Molecular Weight: 1023.38

Purity: ≥97%

Appearance: Off-white solid

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InChIKey: WGSYKMJXYDETRL-UHFFFAOYSA-N

CanonicalSMILES: CC(C)(C)C(OC1=CC(OC2=C3C=C(Cl)C(OC(C(C)(C)C)=O)=C2)=C(C3(C4=C(Cl)C=C(C(NCCCCCCOP(OCCC#N)N(C(C)C)C(C)C)=O)C(Cl)=C45)OC5=O)C=C1C6=CC=CC=C6)=O

IUPAC Name: 2',4,7-trichloro-5-((6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamoyl)-3-oxo-7'-phenyl-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C52H59Cl3N3O10P/c1-30(2)58(31(3)4)69(64-24-18-21-56)63-23-17-12-11-16-22-57-46(59)34-26-38(54)44-43(45(34)55)47(60)68-52(44)35-25-33(32-19-14-13-15-20-32)39(66-48(61)50(5,6)7)28-40(35)65-41-29-42(37(53)27-36(41)52)67-49(62)51(8,9)10/h13-15,19-20,25-31H,11-12,16-18,22-24H2,1-10H3,(H,57,59)

Synonyms: 5-VIC Phosphoramidite; VIC phosphoramidite, 5-isomer

5-Me-5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite

Description: 5-Me-5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite is used in the synthesis of modified oligonucleotides to enhance their stability, specificity, and resistance to enzymatic degradation, making it valuable for developing therapeutic agents such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and enzymatic processes in research.

CAT: BRP-01540

Molecular Formula: C42H51FN5O8P

Molecular Weight: 803.87

Purity: >98%

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: XKIOEQRURPSLHT-FNZMFDOGSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H51FN5O8P/c1-27(2)48(28(3)4)57(54-24-12-23-44)56-38-36(55-40(37(38)43)47-25-29(5)39(45-30(6)49)46-41(47)50)26-53-42(31-13-10-9-11-14-31,32-15-19-34(51-7)20-16-32)33-17-21-35(52-8)22-18-33/h9-11,13-22,25,27-28,36-38,40H,12,24,26H2,1-8H3,(H,45,46,49,50)/t36-,37-,38-,40-,57?/m1/s1

Synonyms: 2'-F MeC(Ac) amidite; N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite; 2'-Fluoro-5MeC(Ac)-3'-phosphoramidite; 5-Me-N4-Ac-5'-O-DMT-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methylcytidine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; N4-Ac-5'-O-DMTr-2'-deoxy-2'-fluoro-5-methylcytidine-3'-CED phosphoramidite; N-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite; DMT-2'-F-dC(Ac)-CE-Phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyuridine-3'-cyanoethyl-phosphoramidite

Description: 5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyuridine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated synthesis of modified oligonucleotides. This reagent includes a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position for increased stability and resistance to enzymatic degradation, uridine as the nucleobase, and a cyanoethyl (CE) phosphoramidite group at the 3' position for efficient nucleotide addition during synthesis. It is employed to create oligonucleotides with enhanced stability and specificity, making it valuable for therapeutic applications like antisense oligonucleotides and siRNAs, as well as for researching nucleic acid interactions and enzymatic processes.

CAT: BRP-01542

CAS: 126139-44-4

Molecular Formula: C41H47F3N5O9P

Molecular Weight: 841.82

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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Storage: Store at -20 °C

Melting Point: 240-243 °C

InChIKey: SSRAEXJTISFPEB-WEYVJJSGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1NC(=O)C(F)(F)F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C41H47F3N5O9P/c1-26(2)49(27(3)4)59(56-24-10-22-45)58-36-33(57-37(35(36)47-38(51)41(42,43)44)48-23-21-34(50)46-39(48)52)25-55-40(28-11-8-7-9-12-28,29-13-17-31(53-5)18-14-29)30-15-19-32(54-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,47,51)(H,46,50,52)/t33-,35-,36-,37-,59?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-U-3'-CE-Phosphoramidite; 2'-Deoxy-2'-(N-trifluoroacetyl)amino-5'-O-DMTr-uridine 3'-CED phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-[(2,2,2-trifluoroacetyl)amino]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-Amino(TFA) U amidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl-phosphoramidite

Description: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated chemical synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group, a trifluoroacetamido group at the 2' position for enhanced stability and resistance to enzymatic degradation, an acetyl-protected cytosine base, and a cyanoethyl (CE) phosphoramidite group at the 3' position, facilitating the stepwise addition of nucleotides. This reagent is essential for synthesizing oligonucleotides with improved stability and specificity for therapeutic applications, such as antisense oligonucleotides and siRNAs, as well as for advanced research in nucleic acid interactions and enzymatic processes.

CAT: BRP-01543

Molecular Formula: C43H50F3N6O9P

Molecular Weight: 882.88

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: YKZVUVJTYKUQET-BVGHISPXSA-N

IUPAC Name: (2R,3S,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H50F3N6O9P/c1-27(2)52(28(3)4)62(59-25-11-23-47)61-38-35(60-39(37(38)50-40(54)43(44,45)46)51-24-22-36(48-29(5)53)49-41(51)55)26-58-42(30-12-9-8-10-13-30,31-14-18-33(56-6)19-15-31)32-16-20-34(57-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,50,54)(H,48,49,53,55)/t35-,37-,38-,39-,62?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-C(Ac)-3'-CE-Phosphoramidite; Cytidine, N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-[(trifluoroacetyl)amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-Amino(TFA) C(Ac) amidite

N4-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl phosphoramidite

Description: N4-Benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl phosphoramidite is a phosphoramidite reagent used in the automated synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position to enhance stability and resistance to enzymatic degradation, a benzoyl-protected cytosine base (C(Bz)), and a cyanoethyl (CE) phosphoramidite group at the 3' position for efficient nucleotide addition during synthesis. This reagent is used to create oligonucleotides with improved stability and specificity, which are valuable for therapeutic applications such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and enzymatic processes.

CAT: BRP-01544

CAS: 176755-95-6

Molecular Formula: C48H52F3N6O9P

Molecular Weight: 944.93

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: KXMNUCKTZFTECT-AYACJNLVSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1NC(=O)C(F)(F)F)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H52F3N6O9P/c1-31(2)57(32(3)4)67(64-29-13-27-52)66-42-39(30-63-47(34-16-11-8-12-17-34,35-18-22-37(61-5)23-19-35)36-20-24-38(62-6)25-21-36)65-44(41(42)55-45(59)48(49,50)51)56-28-26-40(54-46(56)60)53-43(58)33-14-9-7-10-15-33/h7-12,14-26,28,31-32,39,41-42,44H,13,29-30H2,1-6H3,(H,55,59)(H,53,54,58,60)/t39-,41-,42-,44-,67?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-C(Bz)-3'-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-[(trifluoroacetyl)amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-Amino(TFA) C(Bz) amidite

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyadenosine-3'-cyanoethyl-phosphoramidite

Description: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyadenosine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated synthesis of modified oligonucleotides. This compound includes a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position to enhance stability and resistance to enzymatic degradation, a benzoyl-protected adenosine base at the N6 position, and a cyanoethyl (CE) phosphoramidite group at the 3' position for efficient nucleotide addition during synthesis. This reagent is employed to create oligonucleotides with enhanced stability and specificity, making it valuable for therapeutic applications such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and enzymatic processes.

CAT: BRP-01545

Molecular Formula: C49H52F3N8O8P

Molecular Weight: 968.97

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: MRKCOSUIEKSHSN-MRKXKXNLSA-N

IUPAC Name: (2R,3S,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H52F3N8O8P/c1-31(2)60(32(3)4)69(66-27-13-26-53)68-42-39(28-65-48(34-16-11-8-12-17-34,35-18-22-37(63-5)23-19-35)36-20-24-38(64-6)25-21-36)67-46(40(42)57-47(62)49(50,51)52)59-30-56-41-43(54-29-55-44(41)59)58-45(61)33-14-9-7-10-15-33/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,57,62)(H,54,55,58,61)/t39-,40-,42-,46-,69?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-A(Bz)-3'-CE-Phosphoramidite

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyguanosine-3'-cyanoethyl-phosphoramidite

Description: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyguanosine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated chemical synthesis of modified oligonucleotides. It features a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position for enhanced stability and resistance to enzymatic degradation, an isobutyryl-protected guanosine base at the N2 position, and a cyanoethyl (CE) phosphoramidite group at the 3' position to facilitate the stepwise addition of nucleotides. This reagent is utilized to produce oligonucleotides with improved stability and specificity, making it valuable for therapeutic applications such as antisense oligonucleotides and siRNAs, as well as for advanced research in nucleic acid interactions and enzymatic processes.

CAT: BRP-01546

Molecular Formula: C46H54F3N8O9P

Molecular Weight: 950.95

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: KTSIVWAECVXZMP-OMTUQZFCSA-N

IUPAC Name: (2R,3S,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H54F3N8O9P/c1-27(2)40(58)54-44-53-39-37(41(59)55-44)51-26-56(39)42-36(52-43(60)46(47,48)49)38(66-67(64-24-12-23-50)57(28(3)4)29(5)6)35(65-42)25-63-45(30-13-10-9-11-14-30,31-15-19-33(61-7)20-16-31)32-17-21-34(62-8)22-18-32/h9-11,13-22,26-29,35-36,38,42H,12,24-25H2,1-8H3,(H,52,60)(H2,53,54,55,58,59)/t35-,36-,38-,42-,67?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-G(iBu)-3'-CE-Phosphoramidite

N2-Isobutyryl-5'-O-(4-methoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-cyanoethyl phosphoramidite

Description: N2-Isobutyryl-5'-O-(4-methoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-cyanoethyl Phosphoramidite plays a crucial role in oligonucleotide synthesis, enhancing stability and specificity through its chemical modifications. The 2'-fluoro substitution increases resistance to enzymatic degradation, while the N2-isobutyryl and 4-methoxytrityl protecting groups ensure precise assembly and protection during synthesis. This compound is instrumental in developing oligonucleotides with tailored properties for applications in therapeutic RNA interference (RNAi), antisense technology, and in-depth studies of nucleic acid interactions and enzymatic processes in molecular biology research.

CAT: BRP-01551

Molecular Formula: C43H51FN7O7P

Molecular Weight: 827.90

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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Storage: Store at -20 °C

InChIKey: KHJOOLJXPINFLJ-WCRQIFRASA-N

CanonicalSMILES: N#CCCOP(OC1C(F)C(OC1COC(C=2C=CC=CC2)(C=3C=CC=CC3)C4=CC=C(OC)C=C4)N5C=NC=6C(=O)N=C(NC(=O)C(C)C)NC65)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C43H51FN7O7P/c1-27(2)39(52)48-42-47-38-36(40(53)49-42)46-26-50(38)41-35(44)37(58-59(56-24-14-23-45)51(28(3)4)29(5)6)34(57-41)25-55-43(30-15-10-8-11-16-30,31-17-12-9-13-18-31)32-19-21-33(54-7)22-20-32/h8-13,15-22,26-29,34-35,37,41H,14,24-25H2,1-7H3,(H2,47,48,49,52,53)/t34-,35-,37-,41-,59?/m1/s1

Synonyms: 5'-O-MMTr-2'-F-dG(iBu) Phosphoramidite

[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

DMTr-O Diethyleneglycol Phosphoramidite

5'-Cholesterol PEG5-CE Phosphoramidite

5'-Biotin Phosphoramidite

ICG-NHS

12-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxypyrrolidin-1-yl)-12-oxododecanoic acid

5'-DMT-PseudoUridine-CE-Phosphoramidite

5'-ODMT cEt G Phosphoramidite (Amidite)

5'-ODMT cEt m5U Phosphoramidite (Amidite)

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)

5'-ODMT cEt U Phosphoramidite (Amidite)

5'-ODMT cEt N-Bz C Phosphoramidite (Amidite)

5-VIC CE Phosphoramidite

5-Me-5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyuridine-3'-cyanoethyl-phosphoramidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl-phosphoramidite

N4-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl phosphoramidite

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyadenosine-3'-cyanoethyl-phosphoramidite

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyguanosine-3'-cyanoethyl-phosphoramidite

N2-Isobutyryl-5'-O-(4-methoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-cyanoethyl phosphoramidite

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