What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

5'-O-DMTr-2'-O-Me-G(Ac) PACE amidite

Description: This amidite incorporates a guanine nucleoside modified with a 5'-dimethoxytrityl (DMTr) group and a 2'-O-methyl (Me) group, along with an acetyl (Ac) group at the base. It is used in oligonucleotide synthesis to introduce modified guanine residues, offering versatility in structure and function studies of nucleic acids.

CAT: BRP-01179

Molecular Formula: C47H58N7O10P

Molecular Weight: 911.99

Purity: ≥98% by HPLC

Appearance: White to pale yellow solid

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Storage: Store at -20 °C

InChIKey: QQXUTIPUYDMWLY-JONXRGCJSA-N

IUPAC Name: 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

InChI: InChI=1S/C47H58N7O10P/c1-29(2)54(30(3)4)65(27-38(56)63-46(6,7)24-25-48)64-40-37(62-44(41(40)60-10)53-28-49-39-42(53)51-45(50-31(5)55)52-43(39)57)26-61-47(32-14-12-11-13-15-32,33-16-20-35(58-8)21-17-33)34-18-22-36(59-9)23-19-34/h11-23,28-30,37,40-41,44H,24,26-27H2,1-10H3,(H2,50,51,52,55,57)/t37-,40-,41-,44-,65?/m1/s1

Synonyms: 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylguanosine; 5'-O-DMTr-2'-O-Me-G(Ac) PACE; 5'-O-DMTr-2'-O-Me-G(Ac) PACE Phosphoramidite

Morpholino A(Ceoc) subunit

Description: This subunit consists of a morpholino ring (a six-membered morpholine ring) modified with a Ceoc group attached to an adenine base. Morpholinos are synthetic nucleic acid analogs used primarily as antisense agents to block gene expression by binding to complementary RNA sequences, offering potential therapeutic applications in gene regulation and disease treatment.

CAT: BRP-01180

Molecular Formula: C35H36ClN8O5P

Molecular Weight: 715.15

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C

InChIKey: AELIKKSXAYGGHK-YYNRDWDXSA-N

IUPAC Name: 2-cyanoethyl (9-((2R,6S)-6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-9H-purin-6-yl)carbamate

InChI: InChI=1S/C35H36ClN8O5P/c1-42(2)50(36,46)48-23-29-21-43(35(26-13-6-3-7-14-26,27-15-8-4-9-16-27)28-17-10-5-11-18-28)22-30(49-29)44-25-40-31-32(38-24-39-33(31)44)41-34(45)47-20-12-19-37/h3-11,13-18,24-25,29-30H,12,20-23H2,1-2H3,(H,38,39,41,45)/t29-,30+,50?/m0/s1

Synonyms: 2-cyanoethyl (9-(6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-9H-purin-6-yl)carbamate

Morpholino C(Ceoc) subunit

Description: This variant features a morpholino ring modified with a Ceoc group linked to a cytosine base. It serves similar purposes as the A(Ceoc) subunit in antisense technology, facilitating selective binding to RNA targets for gene knockdown and therapeutic interventions.

CAT: BRP-01181

Molecular Formula: C34H36ClN6O6P

Molecular Weight: 691.12

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C

InChIKey: NNFJEBJVHVPSJG-HYZMJWPCSA-N

IUPAC Name: 2-cyanoethyl (1-((2R,6S)-6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

InChI: InChI=1S/C34H36ClN6O6P/c1-39(2)48(35,44)46-25-29-23-40(24-31(47-29)41-21-19-30(37-32(41)42)38-33(43)45-22-12-20-36)34(26-13-6-3-7-14-26,27-15-8-4-9-16-27)28-17-10-5-11-18-28/h3-11,13-19,21,29,31H,12,22-25H2,1-2H3,(H,37,38,42,43)/t29-,31+,48?/m0/s1

Synonyms: 2-cyanoethyl (1-(6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Boc-PNA-A(Z)-OH

Description: Boc-PNA-A(Z)-OH is a synthetic peptide nucleic acid (PNA) monomer with an adenine base. It features a Boc (tert-butyloxycarbonyl) protecting group and a Z (benzyloxycarbonyl) group. This monomer is used in the synthesis of PNA oligomers for research in molecular biology and genetics, particularly for studying DNA and RNA binding and hybridization.

CAT: BRP-01183

CAS: 149376-69-2

Molecular Formula: C24H29N7O7

Molecular Weight: 527.53

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.38±0.1 g/cm3

Melting Point: 119 °C (dec.)

InChIKey: HNSNKXSLRGSKQN-UHFFFAOYSA-N

CanonicalSMILES: CC(C)(C)OC(=O)NCCN(CC(=O)O)C(=O)CN1C=NC2=C(N=CN=C21)NC(=O)OCC3=CC=CC=C3

IUPAC Name: 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl-[2-[6-(phenylmethoxycarbonylamino)purin-9-yl]acetyl]amino]acetic acid

InChI: InChI=1S/C24H29N7O7/c1-24(2,3)38-22(35)25-9-10-30(12-18(33)34)17(32)11-31-15-28-19-20(26-14-27-21(19)31)29-23(36)37-13-16-7-5-4-6-8-16/h4-8,14-15H,9-13H2,1-3H3,(H,25,35)(H,33,34)(H,26,27,29,36)

Synonyms: N-((N6-(benzyloxycarbonyl)adenin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycine; N-(2-(6-(((Benzyloxy)carbonyl)amino)-9H-purin-9-yl)acetyl)-N-(2-((tert-butoxycarbonyl)amino)ethyl)glycine; N-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]-N-[2-[6-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl]acetyl]glycine

N1-Me-5'-O-DMTr-2'-O-TBDMS-G(dmf)-3'-CE-Phosphoramidite

Description: This phosphoramidite consists of a guanosine nucleoside modified with N1-methyl (N1-Me), 5'-dimethoxytrityl (DMTr), 2'-O-tert-butyldimethylsilyl (TBDMS), and a dmf (dimethylformamide) group linked to the base. It is used in solid-phase synthesis to introduce modified guanosine residues into oligonucleotides, providing stability and compatibility during synthesis.

CAT: BRP-01184

Molecular Formula: C50H69N8O8PSi

Molecular Weight: 969.21

Purity: ≥97% by HPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C

InChIKey: VNPNGTSSGZPPHO-PGKNMGFDSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N(C(N=CN(C)C)=NC32)C)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((dimethylamino)methylene)amino)-1-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H69N8O8PSi/c1-34(2)58(35(3)4)67(63-30-18-29-51)65-43-41(31-62-50(36-19-16-15-17-20-36,37-21-25-39(60-11)26-22-37)38-23-27-40(61-12)28-24-38)64-47(44(43)66-68(13,14)49(5,6)7)57-33-52-42-45(57)54-48(53-32-55(8)9)56(10)46(42)59/h15-17,19-28,32-35,41,43-44,47H,18,30-31H2,1-14H3/t41-,43-,44-,47-,67?/m1/s1

Synonyms: N1-methyl-N2-dimethylformamide-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

5'-O-DMT-2'-O-TBDMS-G(Me)-3'-CE-Phosphoramidite

Description: This phosphoramidite contains a guanosine nucleoside modified with a 5'-dimethoxytrityl (DMT) group, a 2'-O-tert-butyldimethylsilyl (TBDMS) group, and a methyl (Me) group. It is utilized in oligonucleotide synthesis to incorporate guanine modifications, offering enhanced stability and specificity in nucleic acid interactions.

CAT: BRP-01185

Molecular Formula: C47H64N7O8PSi

Molecular Weight: 914.13

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C

InChIKey: RNYXUWAQJPNBRD-SLLDXECHSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(methylamino)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H64N7O8PSi/c1-31(2)54(32(3)4)63(59-28-16-27-48)61-40-38(60-44(41(40)62-64(11,12)46(5,6)7)53-30-50-39-42(53)51-45(49-8)52-43(39)55)29-58-47(33-17-14-13-15-18-33,34-19-23-36(56-9)24-20-34)35-21-25-37(57-10)26-22-35/h13-15,17-26,30-32,38,40-41,44H,16,28-29H2,1-12H3,(H2,49,51,52,55)/t38-,40-,41-,44-,63?/m1/s1

Synonyms: N2-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-dG(Me)-3'-CE-Phosphoramidite

N1-Me-5'-O-DMTr-2'-O-TBDMS-G(iPr-pac)-3'-CE-Phosphoramidite

Description: This phosphoramidite features a guanosine nucleoside with N1-methyl (N1-Me), 5'-dimethoxytrityl (DMTr), 2'-O-tert-butyldimethylsilyl (TBDMS), and isopropylphenoxyacetyl (iPr-Pac)-protected phosphoramidite groups. It is employed in oligonucleotide synthesis to introduce modified guanine residues, enhancing stability and functionality for various biomedical and research applications.

CAT: BRP-01186

Molecular Formula: C58H76N7O10PSi

Molecular Weight: 1090.34

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C

InChIKey: FDSKQAUYTVNZJK-YCBNDBQVSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(2-(4-isopropylphenoxy)acetamido)-1-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C58H76N7O10PSi/c1-38(2)41-21-27-47(28-22-41)70-36-49(66)61-56-62-53-50(54(67)63(56)10)60-37-64(53)55-52(75-77(13,14)57(7,8)9)51(74-76(72-34-18-33-59)65(39(3)4)40(5)6)48(73-55)35-71-58(42-19-16-15-17-20-42,43-23-29-45(68-11)30-24-43)44-25-31-46(69-12)32-26-44/h15-17,19-32,37-40,48,51-52,55H,18,34-36H2,1-14H3,(H,61,62,66)/t48-,51-,52-,55-,76?/m1/s1

Synonyms: N1-methyl-N2-(p-isopropyl-phenoxyacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

2'-O-TBDMS-5'-trifluoroacetamido-U-3'-CE-Phosphoramidite

Description: This phosphoramidite contains a uridine nucleoside modified with a 2'-O-tert-butyldimethylsilyl (TBDMS) group and a 5'-trifluoroacetamido (TFA) group. It is used in oligonucleotide synthesis to incorporate modified uridine residues, providing enhanced stability and specific interactions in nucleic acid hybridization studies and therapeutic applications.

CAT: BRP-01187

Molecular Formula: C26H43F3N5O7PSi

Molecular Weight: 653.70

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20 °C

InChIKey: JJJISHQDDQBWAN-OJHMZDIXSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((2,2,2-trifluoroacetamido)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C26H43F3N5O7PSi/c1-16(2)34(17(3)4)42(38-14-10-12-30)40-20-18(15-31-23(36)26(27,28)29)39-22(33-13-11-19(35)32-24(33)37)21(20)41-43(8,9)25(5,6)7/h11,13,16-18,20-22H,10,14-15H2,1-9H3,(H,31,36)(H,32,35,37)/t18-,20-,21-,22-,42?/m1/s1

Synonyms: 2'-O-(t-butyl-dimethylsilyl)-5'-trifluoroacetamido-uridine-3'-[(2-cyanoethyl)-N,N-diisopropyl] phosphoramidite

[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-U](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-U](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-OMe-uridine (U), a second 2'-OMe-uridine, and a third 2'-OMe-uridine. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01188

Molecular Formula: C66H81N10O25P3

Molecular Weight: 1507.34

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20 °C

InChIKey: RVLLLKZWUNUMEY-BNMQGBNESA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C66H81N10O25P3/c1-41(2)76(42(3)4)102(91-35-13-29-67)99-54-49(97-60(57(54)87-7)73-32-26-51(77)70-63(73)80)39-94-103(83,92-36-14-30-68)101-56-50(98-62(59(56)89-9)75-34-28-53(79)72-65(75)82)40-95-104(84,93-37-15-31-69)100-55-48(96-61(58(55)88-8)74-33-27-52(78)71-64(74)81)38-90-66(43-16-11-10-12-17-43,44-18-22-46(85-5)23-19-44)45-20-24-47(86-6)25-21-45/h10-12,16-28,32-34,41-42,48-50,54-62H,13-15,35-40H2,1-9H3,(H,70,77,80)(H,71,78,81)(H,72,79,82)/t48-,49-,50-,54-,55-,56-,57-,58-,59-,60-,61-,62-,102?,103?,104?/m1/s1

Synonyms: mU[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-U](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]mU-mU

PMO-CAG trimer phosphoramidochloridate

Description: PMO-CAG trimer phosphoramidochloridate is a chemically modified oligonucleotide used in molecular biology and therapeutic applications. It consists of a trimer sequence (Cytosine-Adenine-Guanine, CAG) within a phosphorodiamidate morpholino oligomer (PMO) backbone. The phosphoramidate group is modified with a chloridate moiety, which aids in coupling the trimer to other molecular structures or sequences during synthesis. This configuration enhances the stability, binding affinity, and resistance to nucleases, making it a valuable tool for gene modulation, antisense therapies, and other nucleic acid-based applications.

CAT: BRP-01189

Molecular Formula: C80H90ClN20O16P3

Molecular Weight: 1716.10

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20 °C

InChIKey: NCZHWRORJFEAOK-UTKGGJPZSA-N

IUPAC Name: ((2S,6R)-6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-((((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-((dimethylamino)(((2S,6R)-6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)phosphoryl)morpholin-2-yl)methoxy)(dimethylamino)phosphoryl)morpholin-2-yl)methyl dimethylphosphoramidochloridate

InChI: InChI=1S/C80H90ClN20O16P3/c1-54(2)74(102)90-78-89-73-70(77(91-78)111-41-39-55-34-36-61(37-35-55)101(106)107)85-53-100(73)66-45-95(80(58-28-18-11-19-29-58,59-30-20-12-21-31-59)60-32-22-13-23-33-60)42-62(115-66)49-113-120(110,94(7)8)97-44-64(117-68(47-97)99-52-84-69-71(82-51-83-72(69)99)88-76(104)57-26-16-10-17-27-57)50-114-119(109,93(5)6)96-43-63(48-112-118(81,108)92(3)4)116-67(46-96)98-40-38-65(87-79(98)105)86-75(103)56-24-14-9-15-25-56/h9-38,40,51-54,62-64,66-68H,39,41-50H2,1-8H3,(H,82,83,88,104)(H,86,87,103,105)(H,89,90,91,102)/t62-,63-,64-,66+,67+,68+,118?,119?,120?/m0/s1

Synonyms: PMO-C(Ac)A(Bz)G(iBu) trimer phosphoramidochloridate

[5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-U](pCyEt)[2'-F-dG(iBu)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-U](pCyEt)[2'-F-dG(iBu)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, a 2'-O-methyl-uridine (2'-OMe-U), and a 2'-fluoro-deoxyguanosine (2'-F-dG) with an isobutyryl (iBu) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01190

Molecular Formula: C71H85F2N14O23P3

Molecular Weight: 1633.45

Purity: ≥92% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20 °C

InChIKey: LFFQMQJBVLQFPU-VKWGPYKVSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C71H85F2N14O23P3/c1-41(2)63(90)82-68-81-62-57(64(91)83-68)77-40-86(62)66-55(72)58(108-111(100-34-14-29-74)87(42(3)4)43(5)6)51(106-66)38-103-113(95,102-36-16-31-76)110-60-52(107-67(61(60)98-10)85-33-28-54(89)80-70(85)93)39-104-112(94,101-35-15-30-75)109-59-50(105-65(56(59)73)84-32-27-53(78-44(7)88)79-69(84)92)37-99-71(45-17-12-11-13-18-45,46-19-23-48(96-8)24-20-46)47-21-25-49(97-9)26-22-47/h11-13,17-28,32-33,40-43,50-52,55-56,58-61,65-67H,14-16,34-39H2,1-10H3,(H,80,89,93)(H,78,79,88,92)(H2,81,82,83,90,91)/t50-,51-,52-,55-,56-,58-,59-,60-,61-,65-,66-,67-,111?,112?,113?/m1/s1

mU[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]-mG-Mu

Description: mU[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]-mG-Mu is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-uridine (2'-OMe-U), a 2'-O-methyl-guanosine (2'-OMe-G) with an isobutyryl (iBu) protecting group, and another 2'-O-methyl-uridine (2'-OMe-U). Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01191

Molecular Formula: C71H88N13O25P3

Molecular Weight: 1616.47

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: LHSQAKDMIMJKFU-FSOKJIOASA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C71H88N13O25P3/c1-42(2)63(87)79-68-78-62-55(64(88)80-68)75-41-83(62)67-61(97-11)58(109-111(91,100-36-16-31-73)102-39-51-56(107-110(99-35-15-30-72)84(43(3)4)44(5)6)59(95-9)65(105-51)81-33-28-53(85)76-69(81)89)52(106-67)40-103-112(92,101-37-17-32-74)108-57-50(104-66(60(57)96-10)82-34-29-54(86)77-70(82)90)38-98-71(45-18-13-12-14-19-45,46-20-24-48(93-7)25-21-46)47-22-26-49(94-8)27-23-47/h12-14,18-29,33-34,41-44,50-52,56-61,65-67H,15-17,35-40H2,1-11H3,(H,76,85,89)(H,77,86,90)(H2,78,79,80,87,88)/t50-,51-,52-,56-,57-,58-,59-,60-,61-,65-,66-,67-,110?,111?,112?/m1/s1

Synonyms: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]; UmGmUm

[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U](P-thio-pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U](P-thio-pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-cytidine (2'-OMe-C) with an acetyl (Ac) protecting group, a 2'-O-methyl-uridine (2'-OMe-U), and a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group. Each linkage is protected by a phosphorothioate (P-thio) group and a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01192

Molecular Formula: C76H89N14O22P3S2

Molecular Weight: 1707.67

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: YRUITVGNVXNUNZ-QPPMCZIUSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(6-benzamido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C76H89N14O22P3S2/c1-47(2)90(48(3)4)113(102-39-17-34-77)110-62-57(108-73(65(62)98-8)89-46-82-61-68(80-45-81-69(61)89)86-70(93)50-20-13-11-14-21-50)43-105-114(116,103-40-18-35-78)112-64-58(109-72(67(64)100-10)88-38-33-60(92)85-75(88)95)44-106-115(117,104-41-19-36-79)111-63-56(107-71(66(63)99-9)87-37-32-59(83-49(5)91)84-74(87)94)42-101-76(51-22-15-12-16-23-51,52-24-28-54(96-6)29-25-52)53-26-30-55(97-7)31-27-53/h11-16,20-33,37-38,45-48,56-58,62-67,71-73H,17-19,39-44H2,1-10H3,(H,85,92,95)(H,80,81,86,93)(H,83,84,91,94)/t56-,57-,58-,62-,63-,64-,65-,66-,67-,71-,72-,73-,113?,114?,115?/m1/s1

Synonyms: mC[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U](P-thio-pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]mU-mA

[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-uridine (2'-OMe-U), a 2'-O-methyl-guanosine (2'-OMe-G) with an isobutyryl (iBu) protecting group, and a 2'-O-methyl-cytidine (2'-OMe-C) with an acetyl (Ac) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01193

Molecular Formula: C73H91N14O25P3

Molecular Weight: 1657.53

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: CTRIMGUISJCSNZ-VILHZJDJSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C73H91N14O25P3/c1-43(2)65(90)82-70-81-64-57(66(91)83-70)77-42-86(64)69-63(100-12)60(112-114(94,103-37-17-32-75)105-40-53-58(110-113(102-36-16-31-74)87(44(3)4)45(5)6)61(98-10)67(108-53)84-34-29-55(78-46(7)88)79-71(84)92)54(109-69)41-106-115(95,104-38-18-33-76)111-59-52(107-68(62(59)99-11)85-35-30-56(89)80-72(85)93)39-101-73(47-19-14-13-15-20-47,48-21-25-50(96-8)26-22-48)49-23-27-51(97-9)28-24-49/h13-15,19-30,34-35,42-45,52-54,58-63,67-69H,16-18,36-41H2,1-12H3,(H,80,89,93)(H,78,79,88,92)(H2,81,82,83,90,91)/t52-,53-,54-,58-,59-,60-,61-,62-,63-,67-,68-,69-,113?,114?,115?/m1/s1

Synonyms: mU[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite]mG-mC

[5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-guanosine (2'-OMe-G) with an isobutyryl (iBu) protecting group, a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, and a 2'-O-methyl-cytidine (2'-OMe-C) with an acetyl (Ac) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01194

Molecular Formula: C81H96N17O24P3

Molecular Weight: 1784.68

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: OTKBGJKLKVYCOV-FEONMEANSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C81H96N17O24P3/c1-48(2)73(100)93-79-92-72-63(75(102)94-79)88-47-97(72)78-68(109-11)65(58(117-78)42-111-81(53-24-17-14-18-25-53,54-26-30-56(106-8)31-27-54)55-28-32-57(107-9)33-29-55)121-125(105,114-41-21-37-84)116-44-60-66(69(110-12)77(119-60)96-46-87-62-70(85-45-86-71(62)96)91-74(101)52-22-15-13-16-23-52)122-124(104,113-40-20-36-83)115-43-59-64(120-123(112-39-19-35-82)98(49(3)4)50(5)6)67(108-10)76(118-59)95-38-34-61(89-51(7)99)90-80(95)103/h13-18,22-34,38,45-50,58-60,64-69,76-78H,19-21,39-44H2,1-12H3,(H,85,86,91,101)(H,89,90,99,103)(H2,92,93,94,100,102)/t58-,59-,60-,64-,65-,66-,67-,68-,69-,76-,77-,78-,123?,124?,125?/m1/s1

Synonyms: mG[5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite]mA-mC

TFA-Aminobutyl-1-3-propanediol-DMT succinate, TEA salt

Description: TFA-Aminobutyl-1-3-propanediol-DMT succinate, TEA salt, is a synthetic intermediate or compound used in organic chemistry and biochemical research. It features a trifluoroacetyl (TFA) group, an aminobutyl-1,3-propanediol moiety, and a dimethoxytrityl (DMT) protection group linked to a succinate modification. This compound is utilized in solid-phase synthesis of molecules and potentially in drug discovery processes where chemical modifications and protection groups are essential for the development and manipulation of organic molecules.

CAT: BRP-01241

Molecular Formula: C34H38F3NO8 (free acid)

Molecular Weight: 645.67 (free acid)

Purity: ≥98% by UPLC

Appearance: Colorless to yellow oily matter

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IUPAC Name: 4-((2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-(2,2,2-trifluoroacetamido)hexyl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: Trifluoroacetatyl-Aminobutyl-1-3-Propanediol-DMT Succinate, TEA salt

3-O-DMT-2,2-(dicarboxymethylamido)propyl-1-O-succinate, TEA salt

Description: 3-O-DMT-2,2-(dicarboxymethylamido)propyl-1-O-succinate, TEA salt is a chemical compound stabilized with triethylamine (TEA) salt. This compound is likely used in organic synthesis as an intermediate or precursor for the modification of biomolecules or organic compounds, particularly in solid-phase synthesis or other chemical reactions requiring stable protection groups and functional groups for further manipulation.

CAT: BRP-01242

Molecular Formula: C32H36N2O9 (free acid)

Molecular Weight: 592.65 (free acid)

Purity: ≥97% by HPLC

Appearance: White, off-white to light yellow powder

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IUPAC Name: 4-(2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(methylamino)-2-(methylcarbamoyl)-3-oxopropoxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 3-(4,4'-dimethoxytrityloxy)-2,2-(dicarboxymethylamido)propyl-1-O-succinate, triethylamine salt

Cholesteryl succinate, TEA salt (plant source)

Description: Cholesteryl succinate, TEA salt (plant source), refers to a compound derived from plants that combines cholesteryl (a cholesterol derivative) with succinic acid, forming a salt stabilized with triethylamine (TEA). This compound is utilized in various biochemical and pharmaceutical applications, particularly in lipid research and drug delivery systems. Cholesteryl derivatives are known for their ability to interact with lipid membranes and cellular structures, making them valuable in studies involving liposomes, lipid-based nanoparticles, and drug formulation.

CAT: BRP-01243

Molecular Formula: C61H86O9 (free acid)

Molecular Weight: 963.35 (free acid)

Purity: ≥98% by HPLC

Appearance: Colorless to faint yellow oily matter

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IUPAC Name: 4-((1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((6-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)hexyl)oxy)propan-2-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 1-(4,4'-Dimethoxytrityloxy)-3-(6-(Cholest-5-en-3β-oxy)hexyloxy) propan-2-succinate, triethylamine salt (plant source)

3'-Thio modifier 6 S-S-DMTr-linker-succinate, TEA salt

Description: 3'-Thio modifier 6 S-S-DMTr-linker-succinate, TEA salt, is a specialized chemical compound used in nucleic acid synthesis and modification. The salt form is stabilized with triethylamine (TEA), enhancing its stability and solubility in aqueous solutions commonly used in biochemical research. This compound is crucial in nucleoside chemistry for introducing modifications at the 3' end of nucleic acids, which can alter their stability, interaction properties, or enzymatic resistance. Such modifications are valuable in studies aiming to understand RNA or DNA structure-function relationships, in nucleic acid-based technologies, and in the development of therapeutic oligonucleotides.

CAT: BRP-01244

Molecular Formula: C35H44O9S2 (free acid)

Molecular Weight: 672.85 (free acid)

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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IUPAC Name: 4-[2-[3-[3-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethoxy]propyldisulfanyl]propoxy]ethoxy]-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 1-O-Dimethoxytrityl-3-oxahexyl-disulfide 1'-succinate, triethylamine salt; 1,1-bis(4-methoxyphenyl)-18-oxo-1-phenyl-2,5,14,17-tetraoxa-9,10-dithiahenicosan-21-oic acid, triethylamine salt

Cholesteryl-TEG-succinate (plant source)

Description: Cholesteryl-TEG-succinate (plant source) is a compound derived from plants that combines cholesteryl (a derivative of cholesterol) with succinic acid, incorporating a tetraethylene glycol (TEG) linker. This structure is designed to enhance the solubility and stability of cholesteryl in aqueous solutions, making it suitable for various applications in biochemical and pharmaceutical research. In biochemical studies, cholesteryl derivatives are utilized to investigate lipid-protein interactions, lipid-based drug delivery systems, and the formation of liposomes. The addition of a TEG linker further improves the compound's solubility and allows for conjugation with other molecules or attachment to surfaces, potentially facilitating its use in drug delivery vehicles or biomaterials.

CAT: BRP-01245

CAS: 873435-28-0

Molecular Formula: C65H93NO13

Molecular Weight: 1096.45

Purity: ≥98% by HPLC

Appearance: Colorless to faint yellow oily matter

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InChIKey: YSSIXSBUMAIUOE-MFCMZYHHSA-N

IUPAC Name: 17-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-1-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-1,19-dioxo-6,9,12,15,18-pentaoxa-2-azadocosan-22-oic acid

InChI: InChI=1S/C65H93NO13/c1-46(2)13-11-14-47(3)57-27-28-58-56-26-21-51-43-54(31-33-63(51,4)59(56)32-34-64(57,58)5)79-62(70)66-35-12-36-73-37-38-74-39-40-75-41-42-76-44-55(78-61(69)30-29-60(67)68)45-77-65(48-15-9-8-10-16-48,49-17-22-52(71-6)23-18-49)50-19-24-53(72-7)25-20-50/h8-10,15-25,46-47,54-59H,11-14,26-45H2,1-7H3,(H,66,70)(H,67,68)/t47-,54+,55?,56+,57-,58+,59+,63+,64-/m1/s1

Synonyms: Cholest-5-en-3-ol (3β)-, 3-(22-hydrogen 17-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-19-oxo-6,9,12,15,18-pentaoxa-2-azadocosanedioate)