What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

FNA G(Ac) amidite

Description: FNA G(Ac) amidite is a phosphoramidite reagent used in solid-phase oligonucleotide synthesis, specifically for the incorporation of FNA monomers into oligonucleotide sequences. FNA G(Ac) amidite contains an acetyl (Ac) protecting group on the guanine base. It is utilized for the synthesis of modified oligonucleotides containing FNA nucleotide analogs, which confer enhanced nuclease resistance and stability to the oligonucleotide duplexes. It finds applications in antisense technology, RNA interference (RNAi), and other nucleic acid-based research fields.

CAT: BRP-00915

CAS: 208758-63-8

Molecular Formula: C41H50N7O8P

Molecular Weight: 799.87

Purity: >98%

Appearance: Off-white solid

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InChIKey: WYKRXWSAMISEIB-COURYUFRSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCC(OCN1C=NC=2NC(=NC(=O)C21)NC(=O)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (R)-2-((2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H50N7O8P/c1-28(2)48(29(3)4)57(55-23-11-22-42)56-25-36(53-27-47-26-43-38-37(47)39(50)46-40(45-38)44-30(5)49)24-54-41(31-12-9-8-10-13-31,32-14-18-34(51-6)19-15-32)33-16-20-35(52-7)21-17-33/h8-10,12-21,26,28-29,36H,11,23-25,27H2,1-7H3,(H2,44,45,46,49,50)/t36-,57?/m1/s1

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, (2R)-2-[[2-(acetylamino)-1,6-dihydro-6-oxo-7H-purin-7-yl]methoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; DMTr-FNA-G(Ac)phosphoramidite

2'-OTBS O6-NPE-G(Me) amidite

Description: 2'-OTBS O6-NPE-G(Me) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a guanosine nucleotide modified at the 2' position with a tert-butyldimethylsilyl (OTBS) protecting group and at the O6 position with a nitrophenylethyl (NPE) group, along with a methyl group modification. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate specifically modified nucleosides into oligonucleotide sequences. Such modifications are important for studies in molecular biology, diagnostics, and therapeutic applications, providing enhanced stability and specific properties to the synthesized oligonucleotides.

CAT: BRP-00916

CAS: 219648-40-5

Molecular Formula: C55H71N8O10PSi

Molecular Weight: 1063.28

Purity: >95%

Appearance: Off-white solid

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InChIKey: DFBXNVVGLXNLNJ-UVQCDVNLSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C2N=C(N=C3OCCC4=CC=C(C=C4)[N+](=O)[O-])NC)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-[2-(methylamino)-6-[2-(4-nitrophenyl)ethoxy]purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C55H71N8O10PSi/c1-37(2)62(38(3)4)74(70-33-16-32-56)72-48-46(35-69-55(40-17-14-13-15-18-40,41-21-27-44(66-9)28-22-41)42-23-29-45(67-10)30-24-42)71-52(49(48)73-75(11,12)54(5,6)7)61-36-58-47-50(61)59-53(57-8)60-51(47)68-34-31-39-19-25-43(26-20-39)63(64)65/h13-15,17-30,36-38,46,48-49,52H,16,31,33-35H2,1-12H3,(H,57,59,60)/t46-,48-,49-,52-,74?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-methyl-6-O-[2-(4-nitrophenyl)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(methylamino)-6-(4-nitrophenethoxy)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-OTBS O6-NPE-G(di-Me) amidite

Description: 2'-OTBS O6-NPE-G(di-Me) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a guanosine nucleotide modified at the 2' position with a tert-butyldimethylsilyl (OTBS) protecting group and at the O6 position with a nitrophenylethyl (NPE) group, along with two methyl (di-Me) group modifications. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate specifically modified nucleosides into oligonucleotide sequences. Such modifications are important for studies in molecular biology, diagnostics, and therapeutic applications, providing enhanced stability and specific properties to the synthesized oligonucleotides.

CAT: BRP-00917

CAS: 2104647-87-0

Molecular Formula: C56H73N8O10PSi

Molecular Weight: 1077.31

Purity: >98%

Appearance: Off-white solid

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InChIKey: ZEHMGNXQYCLVHJ-UTZPLLLRSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC(=NC32)N(C)C)OCCC4=CC=C(C=C4)N(=O)=O)C1O[Si](C)(C)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(dimethylamino)-6-(4-nitrophenethoxy)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C56H73N8O10PSi/c1-38(2)63(39(3)4)75(71-34-17-33-57)73-49-47(36-70-56(41-18-15-14-16-19-41,42-22-28-45(67-10)29-23-42)43-24-30-46(68-11)31-25-43)72-53(50(49)74-76(12,13)55(5,6)7)62-37-58-48-51(62)59-54(61(8)9)60-52(48)69-35-32-40-20-26-44(27-21-40)64(65)66/h14-16,18-31,37-39,47,49-50,53H,17,32,34-36H2,1-13H3/t47-,49-,50-,53-,75?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N,N-dimethyl-6-O-[2-(4-nitrophenyl)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

2'-OTBS N1-Me-I amidite

Description: 2'-OTBS N1-Me-I amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a nucleoside with a tert-butyldimethylsilyl (OTBS) protecting group at the 2' position and a methyl group at the N1 position of the base. This specific modification involves inosine (I), a purine nucleoside. This compound is employed in solid-phase oligonucleotide synthesis to incorporate modified nucleosides into oligonucleotide sequences, providing enhanced stability and specific properties. These modifications are valuable for applications in molecular biology, diagnostics, and therapeutic development.

CAT: BRP-00918

CAS: 236752-21-9

Molecular Formula: C47H63N6O8PSi

Molecular Weight: 899.11

Purity: >95%

Appearance: Off-white solid

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InChIKey: USHFHCSKQCIRHW-UTZPQXNGSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N(C=NC32)C)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(1-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H63N6O8PSi/c1-32(2)53(33(3)4)62(58-28-16-27-48)60-41-39(59-45(42(41)61-63(11,12)46(5,6)7)52-31-49-40-43(52)50-30-51(8)44(40)54)29-57-47(34-17-14-13-15-18-34,35-19-23-37(55-9)24-20-35)36-21-25-38(56-10)26-22-36/h13-15,17-26,30-33,39,41-42,45H,16,28-29H2,1-12H3/t39-,41-,42-,45-,62?/m1/s1

Synonyms: Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-1-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

isoGNA A(Bz) amidite

Description: isoGNA A(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features an adenine (A) base protected with a benzoyl (Bz) group, incorporated into an isoglycerol nucleic acid (isoGNA) backbone. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate modified nucleosides with isoGNA backbones into oligonucleotide sequences. Such modifications are important for enhancing the stability, binding affinity, and specificity of synthetic oligonucleotides, making them useful for applications in molecular biology, diagnostics, and therapeutic research.

CAT: BRP-00919

CAS: 1443744-41-9

Molecular Formula: C45H50N7O6P

Molecular Weight: 815.91

Purity: >95%

Appearance: Off-white solid

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InChIKey: JAPSRHIYKAJUIR-UOJNEOKMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCC(N1C=NC=2C(=NC=NC21)NC(=O)C=3C=CC=CC3)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (S)-2-(6-benzamido-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H50N7O6P/c1-32(2)52(33(3)4)59(57-27-13-26-46)58-29-38(51-31-49-41-42(47-30-48-43(41)51)50-44(53)34-14-9-7-10-15-34)28-56-45(35-16-11-8-12-17-35,36-18-22-39(54-5)23-19-36)37-20-24-40(55-6)25-21-37/h7-12,14-25,30-33,38H,13,27-29H2,1-6H3,(H,47,48,50,53)/t38-,59?/m0/s1

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-2-[6-(benzoylamino)-9H-purin-9-yl]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2S)-2-[6-(Benzoylamino)-9H-purin-9-yl]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

isoGNA C(iBu) amidite

Description: isoGNA C(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a cytosine (C) base protected with an isobutyryl (iBu) group, integrated into an isoglycerol nucleic acid (isoGNA) backbone. This compound is employed in solid-phase oligonucleotide synthesis to incorporate modified nucleosides with isoGNA backbones into oligonucleotide sequences. These modifications enhance the stability, binding affinity, and specificity of synthetic oligonucleotides, making them valuable for various applications in molecular biology, diagnostics, and therapeutic development.

CAT: BRP-00920

CAS: 1443744-42-0

Molecular Formula: C41H52N5O7P

Molecular Weight: 757.87

Purity: >95%

Appearance: Off-white solid

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InChIKey: XGLKXRATAYJCHB-XYMJDGAWSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCC(N1C=CC(=NC1=O)NC(=O)C(C)C)COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N(C(C)C)C(C)C

IUPAC Name: (S)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(4-isobutyramido-2-oxopyrimidin-1(2H)-yl)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H52N5O7P/c1-29(2)39(47)43-38-23-25-45(40(48)44-38)35(28-53-54(52-26-12-24-42)46(30(3)4)31(5)6)27-51-41(32-13-10-9-11-14-32,33-15-19-36(49-7)20-16-33)34-17-21-37(50-8)22-18-34/h9-11,13-23,25,29-31,35H,12,26-28H2,1-8H3,(H,43,44,47,48)/t35-,54?/m0/s1

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[4-[(2-methyl-1-oxopropyl)amino]-2-oxo-1(2H)-pyrimidinyl]propyl 2-cyanoethyl ester; (2S)-3-[Bis(4-methoxyphenyl)phenylmethoxy]-2-[4-[(2-methyl-1-oxopropyl)amino]-2-oxo-1(2H)-pyrimidinyl]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

isoGNA O6-DPC-G(iBu) amidite

Description: isoGNA O6-DPC-G(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a guanine (G) base with an O6-DPC (diphenylcarbamoyl) modification and an isobutyryl (iBu) protecting group, integrated into an isoglycerol nucleic acid (isoGNA) backbone. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate specifically modified nucleosides with isoGNA backbones into oligonucleotide sequences. These modifications are important for enhancing the stability, binding affinity, and specificity of synthetic oligonucleotides, making them valuable for applications in molecular biology, diagnostics, and therapeutic research.

CAT: BRP-00921

CAS: 1638739-09-9

Molecular Formula: C55H61N8O8P

Molecular Weight: 993.12

Purity: >98%

Appearance: Off-white solid

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InChIKey: CNQFTLNOLDNADK-IKGLYBOLSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCC(N1C=NC=2C(=NC(=NC21)NC(=O)C(C)C)OC(=O)N(C=3C=CC=CC3)C=4C=CC=CC4)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: 9-((2S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propan-2-yl)-2-isobutyramido-9H-purin-6-yl diphenylcarbamate

InChI: InChI=1S/C55H61N8O8P/c1-38(2)51(64)59-53-58-50-49(52(60-53)71-54(65)62(44-21-14-10-15-22-44)45-23-16-11-17-24-45)57-37-61(50)46(36-70-72(69-34-18-33-56)63(39(3)4)40(5)6)35-68-55(41-19-12-9-13-20-41,42-25-29-47(66-7)30-26-42)43-27-31-48(67-8)32-28-43/h9-17,19-32,37-40,46H,18,34-36H2,1-8H3,(H,58,59,60,64)/t46-,72?/m0/s1

Synonyms: Carbamic acid, N,N-diphenyl-, 9-[(1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]methyl]ethyl]-2-[(2-methyl-1-oxopropyl)amino]-9H-purin-6-yl ester; 9-[(1S)-2-[Bis(4-methoxyphenyl)phenylmethoxy]-1-[[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]methyl]ethyl]-2-[(2-methyl-1-oxopropyl)amino]-9H-purin-6-yl N,N-diphenylcarbamate

2'-MOE A(Bz) MOP-amidite

Description: 2'-MOE A(Bz) MOP-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features an adenine (A) base protected with a benzoyl (Bz) group and a 2'-O-methoxyethyl (2'-MOE) modification. This compound is employed in solid-phase oligonucleotide synthesis to incorporate nucleosides with 2'-MOE modifications into oligonucleotide sequences. These modifications enhance the stability, binding affinity, and nuclease resistance of synthetic oligonucleotides, making them valuable for various applications in molecular biology, diagnostics, and therapeutic development.

CAT: BRP-00922

CAS: 1821310-27-3

Molecular Formula: C51H63N6O9P

Molecular Weight: 935.07

Purity: >95%

Appearance: Off-white solid

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InChIKey: BZDIHPNWZGXHOG-LTMMGAFGSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)CCCOC)C3OCCOC)C=7C=CC=CC7

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(3-methoxypropyl)phosphaneyl)oxy)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C51H63N6O9P/c1-35(2)57(36(3)4)67(31-15-28-59-5)66-45-43(32-64-51(38-18-13-10-14-19-38,39-20-24-41(61-7)25-21-39)40-22-26-42(62-8)27-23-40)65-50(46(45)63-30-29-60-6)56-34-54-44-47(52-33-53-48(44)56)55-49(58)37-16-11-9-12-17-37/h9-14,16-27,33-36,43,45-46,50H,15,28-32H2,1-8H3,(H,52,53,55,58)/t43-,45-,46-,50-,67?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[P-(3-methoxypropyl)-N,N-bis(1-methylethyl)phosphonamidite]

2'-MOE G(iBu) MOP-amidite

Description: 2'-MOE G(iBu) MOP-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a guanine (G) base protected with an isobutyryl (iBu) group and a 2'-O-methoxyethyl (2'-MOE) modification. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate nucleosides with 2'-MOE modifications into oligonucleotide sequences. These modifications enhance the stability, binding affinity, and nuclease resistance of synthetic oligonucleotides, making them valuable for various applications in molecular biology, diagnostics, and therapeutic development.

CAT: BRP-00923

CAS: 1821310-28-4

Molecular Formula: C48H65N6O10P

Molecular Weight: 917.05

Purity: >95%

Appearance: Off-white solid

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InChIKey: XUVMXOOSPSMHGP-VKFKYRIUSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)CCCOC)C3OCCOC

InChI: InChI=1S/C48H65N6O10P/c1-31(2)44(55)51-47-50-43-40(45(56)52-47)49-30-53(43)46-42(61-27-26-58-8)41(64-65(28-14-25-57-7)54(32(3)4)33(5)6)39(63-46)29-62-48(34-15-12-11-13-16-34,35-17-21-37(59-9)22-18-35)36-19-23-38(60-10)24-20-36/h11-13,15-24,30-33,39,41-42,46H,14,25-29H2,1-10H3,(H2,50,51,52,55,56)/t39-,41-,42-,46-,65?/m1/s1

Synonyms: Guanosine, 5'-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3'-[P-(3-methoxypropyl)-N,N-bis(1-methylethyl)phosphonamidite]

2'-OMe G(iBu) OBn-amidite

Description: 2'-OMe G(iBu) OBn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a guanosine nucleoside modified with a 2'-O-methyl (2'-OMe) group and an isobutyl (iBu) protecting group. Additionally, the benzyl (Bn) group is attached to the phosphoramidite moiety. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified guanosine nucleosides into oligonucleotide sequences. The 2'-O-methyl modification enhances stability, while the isobutyl and benzyl protecting groups provide selective protection during synthesis, allowing precise control over nucleotide incorporation.

CAT: BRP-00930

CAS: 2068810-62-6

Molecular Formula: C49H59N6O9P

Molecular Weight: 907.02

Purity: >95%

Appearance: Off-white solid

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InChIKey: DOXQHYSXYPLQNS-KLJQIIHSSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC=7C=CC=CC7)N(C(C)C)C(C)C)C3OC

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C49H59N6O9P/c1-31(2)45(56)52-48-51-44-41(46(57)53-48)50-30-54(44)47-43(60-9)42(64-65(55(32(3)4)33(5)6)62-28-34-16-12-10-13-17-34)40(63-47)29-61-49(35-18-14-11-15-19-35,36-20-24-38(58-7)25-21-36)37-22-26-39(59-8)27-23-37/h10-27,30-33,40,42-43,47H,28-29H2,1-9H3,(H2,51,52,53,56,57)/t40-,42-,43-,47-,65?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylguanosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-OMe-G(iBu)-3'-benzyloxy-phosphoramidite; N2-iBu 2'-OMe G OBn-amidite; 2'-OMe Guanosine (n-ibu) benzyloxy phosphoramidite

2'-OTIPS 5-propynyl-U Obutyn-amidite

Description: 2'-OTIPS 5-propynyl-U Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a uridine nucleoside modified with a 2'-O-triisopropylsilyl (2'-OTIPS) group and a 3-butynyl (Obutyn) group attached to the phosphoramidite moiety. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified uridine nucleosides into oligonucleotide sequences. The 2'-O-triisopropylsilyl group protects the 2' hydroxyl group, while the 3-butynyl group provides a functional handle for further modification. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.

CAT: BRP-00931

Molecular Formula: C52H70N3O9PSi

Molecular Weight: 940.20

Purity: >95%

Appearance: Off-white solid

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InChIKey: SCESTXDXTKPIHA-WTWWAFAISA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-(prop-1-yn-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-4-((triisopropylsilyl)oxy)tetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C52H70N3O9PSi/c1-15-17-32-61-65(55(35(3)4)36(5)6)63-47-46(62-50(54-33-40(21-16-2)49(56)53-51(54)57)48(47)64-66(37(7)8,38(9)10)39(11)12)34-60-52(41-22-19-18-20-23-41,42-24-28-44(58-13)29-25-42)43-26-30-45(59-14)31-27-43/h1,18-20,22-31,33,35-39,46-48,50H,17,32,34H2,2-14H3,(H,53,56,57)/t46-,47-,48-,50-,65?/m1/s1

2'-OMe U Obutyn-amidite

Description: 2'-OMe U Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a uridine nucleoside modified with a 2'-O-methyl (2'-OMe) group. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified uridine nucleosides into oligonucleotide sequences. The 2'-O-methyl group enhances stability. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.

CAT: BRP-00932

Molecular Formula: C41H50N3O9P

Molecular Weight: 759.84

Purity: >95%

Appearance: Off-white solid

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InChIKey: DDNPMEIKNDZJFN-KCTKLGORSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C41H50N3O9P/c1-9-10-26-51-54(44(28(2)3)29(4)5)53-37-35(52-39(38(37)49-8)43-25-24-36(45)42-40(43)46)27-50-41(30-14-12-11-13-15-30,31-16-20-33(47-6)21-17-31)32-18-22-34(48-7)23-19-32/h1,11-25,28-29,35,37-39H,10,26-27H2,2-8H3,(H,42,45,46)/t35-,37-,38-,39-,54?/m1/s1

2'-OMe A(Bz) Obutyn-amidite

Description: 2'-OMe A(Bz) Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains an adenosine nucleoside modified with a 2'-O-methyl (2'-OMe) group and a benzoyl (Bz) group, with a 3-butynyl (Obutyn) group attached to the phosphoramidite moiety. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified adenosine nucleosides into oligonucleotide sequences. The 2'-O-methyl modification enhances stability, while the benzoyl group serves as a protecting group, and the 3-butynyl group provides a functional handle for further modification. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.

CAT: BRP-00933

CAS: 1840885-68-8

Molecular Formula: C49H55N6O8P

Molecular Weight: 886.99

Purity: >95%

Appearance: Off-white solid

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InChIKey: NEFHXUABIXRDHS-HHRUMCNBSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCCC#C)N(C(C)C)C(C)C)C3OC)C=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C49H55N6O8P/c1-9-10-29-61-64(55(33(2)3)34(4)5)63-43-41(62-48(44(43)59-8)54-32-52-42-45(50-31-51-46(42)54)53-47(56)35-17-13-11-14-18-35)30-60-49(36-19-15-12-16-20-36,37-21-25-39(57-6)26-22-37)38-23-27-40(58-7)28-24-38/h1,11-28,31-34,41,43-44,48H,10,29-30H2,2-8H3,(H,50,51,53,56)/t41-,43-,44-,48-,64?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]

2'-OMe G(iBu) Obutyn-amidite

Description: 2'-OMe G(iBu) Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a guanosine nucleoside modified with a 2'-O-methyl (2'-OMe) group and an isobutyl (iBu) group. This compound is utilized in solid-phase oligonucleotide synthesis to introduce specifically modified guanosine nucleosides into oligonucleotide sequences. The 2'-O-methyl modification enhances stability, while the isobutyl group serves as a protecting group, and the 3-butynyl group provides a functional handle for further modification. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.

CAT: BRP-00934

CAS: 1773534-68-1

Molecular Formula: C46H57N6O9P

Molecular Weight: 868.97

Purity: >97%

Appearance: Off-white solid

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InChIKey: BIFMOLDNUGOVBS-DMWBDYODSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCCC#C)N(C(C)C)C(C)C)C3OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C46H57N6O9P/c1-11-12-26-59-62(52(30(4)5)31(6)7)61-39-37(60-44(40(39)57-10)51-28-47-38-41(51)48-45(50-43(38)54)49-42(53)29(2)3)27-58-46(32-16-14-13-15-17-32,33-18-22-35(55-8)23-19-33)34-20-24-36(56-9)25-21-34/h1,13-25,28-31,37,39-40,44H,12,26-27H2,2-10H3,(H2,48,49,50,53,54)/t37-,39-,40-,44-,62?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]

2'-OMe U OMe-amidite

Description: 2'-OMe U OMe-amidite is a reagent commonly used in oligonucleotide synthesis. It involves a methyl (Me) group at the 2' position of ribose and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This allows for the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.

CAT: BRP-00935

CAS: 110764-77-7

Molecular Formula: C38H48N3O9P

Molecular Weight: 721.79

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: ZFAYUVCJJLJWPV-KQBWMQIQSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C38H48N3O9P/c1-25(2)41(26(3)4)51(47-8)50-34-32(49-36(35(34)46-7)40-23-22-33(42)39-37(40)43)24-48-38(27-12-10-9-11-13-27,28-14-18-30(44-5)19-15-28)29-16-20-31(45-6)21-17-29/h9-23,25-26,32,34-36H,24H2,1-8H3,(H,39,42,43)/t32-,34-,35-,36-,51?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-OMe-U-3'-Methoxy-phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine-3'-Methoxy-phosphoramidite

2'-OMe A(Bz) OMe-amidite

Description: 2'-OMe A(Bz) OMe-amidite is a reagent used in oligonucleotide synthesis. It features a methyl (Me) group at the 2' position of ribose, adenine (A) possibly protected with a benzoyl (Bz) group, and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This facilitates the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.

CAT: BRP-00936

CAS: 110782-30-4

Molecular Formula: C46H53N6O8P

Molecular Weight: 848.94

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: LZPPZAAMMANQFD-HLVGMPGCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3OC)C=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C46H53N6O8P/c1-30(2)52(31(3)4)61(57-8)60-40-38(59-45(41(40)56-7)51-29-49-39-42(47-28-48-43(39)51)50-44(53)32-15-11-9-12-16-32)27-58-46(33-17-13-10-14-18-33,34-19-23-36(54-5)24-20-34)35-21-25-37(55-6)26-22-35/h9-26,28-31,38,40-41,45H,27H2,1-8H3,(H,47,48,50,53)/t38-,40-,41-,45-,61?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-OMe-A(Bz)-3'-Methoxy-phosphoramidite; N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-Adenosine-3'-Methoxy-phosphoramidite

2'-OMe G(iBu) OMe-amidite

Description: 2'-OMe G(iBu) OMe-amidite is a reagent utilized in oligonucleotide synthesis. It consists of a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group, and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This enables the controlled synthesis of modified oligonucleotides with enhanced stability and tailored functionalities.

CAT: BRP-00937

CAS: 179478-96-7

Molecular Formula: C43H55N6O9P

Molecular Weight: 830.92

Purity: >98%

Appearance: White, off-white to faint yellow powder

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InChIKey: ABXYOPVUGHRVTD-BFXRUIMDSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C43H55N6O9P/c1-26(2)39(50)46-42-45-38-35(40(51)47-42)44-25-48(38)41-37(54-9)36(58-59(55-10)49(27(3)4)28(5)6)34(57-41)24-56-43(29-14-12-11-13-15-29,30-16-20-32(52-7)21-17-30)31-18-22-33(53-8)23-19-31/h11-23,25-28,34,36-37,41H,24H2,1-10H3,(H2,45,46,47,50,51)/t34-,36-,37-,41-,59?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-OMe-G(iBu)-3'-Methoxy-phosphoramidite; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine-3'-Methoxy-phosphoramidite

2'-MOE MeC(Bz) OMe-amidite

Description: 2'-OMe MeC(Bz) OMe-amidite is a reagent employed in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, cytosine (C) potentially protected with a benzoyl (Bz) group, and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This facilitates the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.

CAT: BRP-00938

CAS: 647858-99-9

Molecular Formula: C48H59N4O10P

Molecular Weight: 882.99

Purity: >95%

Appearance: Off-white solid

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InChIKey: GVNBZSNXLHGONB-AENBYTAOSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)C(=CN1C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3OCCOC)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C48H59N4O10P/c1-32(2)52(33(3)4)63(58-9)62-42-41(31-60-48(36-18-14-11-15-19-36,37-20-24-39(56-7)25-21-37)38-22-26-40(57-8)27-23-38)61-46(43(42)59-29-28-55-6)51-30-34(5)44(50-47(51)54)49-45(53)35-16-12-10-13-17-35/h10-27,30,32-33,41-43,46H,28-29,31H2,1-9H3,(H,49,50,53,54)/t41-,42-,43-,46-,63?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

2'-OMe G(iBu) (TBSO)SATE-amidite

Description: 2'-OMe G(iBu) (TBSO)SATE-amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group. This reagent enables the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities.

CAT: BRP-00939

Molecular Formula: C55H79N6O11PSSi

Molecular Weight: 1091.40

Purity: >95%

Appearance: Off-white solid

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InChIKey: KNYQSRGOAUUKQY-HYFQDGRXSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C55H79N6O11PSSi/c1-35(2)48(62)58-52-57-47-44(49(63)59-52)56-34-60(47)50-46(67-14)45(72-73(61(36(3)4)37(5)6)69-30-31-74-51(64)54(10,11)33-70-75(15,16)53(7,8)9)43(71-50)32-68-55(38-20-18-17-19-21-38,39-22-26-41(65-12)27-23-39)40-24-28-42(66-13)29-25-40/h17-29,34-37,43,45-46,50H,30-33H2,1-16H3,(H2,57,58,59,62,63)/t43-,45-,46-,50-,73?/m1/s1

2'-OMe A(Bz) (TBSO)SATE-amidite

Description: 2'-OMe A(Bz) (TBSO)SATE-amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group. This reagent enables the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.

CAT: BRP-00940

Molecular Formula: C58H77N6O10PSSi

Molecular Weight: 1109.41

Purity: >95%

Appearance: Off-white solid

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InChIKey: BPRJNTIBJAXHFE-SLDILDNQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C58H77N6O10PSSi/c1-39(2)64(40(3)4)75(71-33-34-76-55(66)57(8,9)36-72-77(13,14)56(5,6)7)74-49-47(73-54(50(49)69-12)63-38-61-48-51(59-37-60-52(48)63)62-53(65)41-21-17-15-18-22-41)35-70-58(42-23-19-16-20-24-42,43-25-29-45(67-10)30-26-43)44-27-31-46(68-11)32-28-44/h15-32,37-40,47,49-50,54H,33-36H2,1-14H3,(H,59,60,62,65)/t47-,49-,50-,54-,75?/m1/s1