Phosphoramidites

2'-OPivOM A(pac) amidite

Description: 2'-O-PivOM A(Pac) amidite is a modified adenosine nucleotide used in oligonucleotide synthesis. It includes a 2'-O-pivaloyloxymethyl group protecting the 2'-hydroxyl and a phenoxyacetyl (Pac) group protecting the exocyclic amino group at the N6 position, enabling precise incorporation during solid-phase synthesis for constructing RNA sequences with desired modifications.

CAT: BRP-00876

CAS: 1097131-21-9

Molecular Formula: C54H64N7O11P

Molecular Weight: 1018.12

Purity: >95%

Appearance: Off-white solid

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InChIKey: JMGAJBBCWCMKLV-PQTVSCHKSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCOC(=O)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: [(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-[6-[(2-phenoxyacetyl)amino]purin-9-yl]oxolan-3-yl]oxymethyl 2,2-dimethylpropanoate

InChI: InChI=1S/C54H64N7O11P/c1-36(2)61(37(3)4)73(70-30-16-29-55)72-47-44(31-69-54(38-17-12-10-13-18-38,39-21-25-41(64-8)26-22-39)40-23-27-42(65-9)28-24-40)71-51(48(47)67-35-68-52(63)53(5,6)7)60-34-58-46-49(56-33-57-50(46)60)59-45(62)32-66-43-19-14-11-15-20-43/h10-15,17-28,33-34,36-37,44,47-48,51H,16,30-32,35H2,1-9H3,(H,56,57,59,62)/t44-,47-,48-,51-,73?/m1/s1

Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2,2-dimethyl-1-oxopropoxy)methyl]-N-(2-phenoxyacetyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; (((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate; 2'-O-PivOM-5'-O-DMT-Adenosine (N-PAC) 3'-CEP

2'-OTBS A(Ac) amidite

Description: 2'-OTBS A(Ac) amidite is a specialized compound used in oligonucleotide synthesis. It contains a nucleoside derivative with a tert-butyldimethylsilyl (OTBS) group protecting the 2'-hydroxyl position of adenosine. Additionally, it features an acetyl (Ac) group attached to the amine group of the adenosine base. This compound enables controlled addition during oligonucleotide synthesis, allowing for precise customization and design of adenosine-modified oligonucleotides for various molecular biology applications, such as RNA interference (RNAi) studies and gene expression analysis.

CAT: BRP-00877

CAS: 1220889-84-8

Molecular Formula: C48H64N7O8PSi

Molecular Weight: 926.14

Purity: >98%

Appearance: Off-white solid

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InChIKey: IISGHHSYMWMWKH-FLEVKJGDSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]acetamide

InChI: InChI=1S/C48H64N7O8PSi/c1-32(2)55(33(3)4)64(60-28-16-27-49)62-42-40(61-46(43(42)63-65(11,12)47(6,7)8)54-31-52-41-44(53-34(5)56)50-30-51-45(41)54)29-59-48(35-17-14-13-15-18-35,36-19-23-38(57-9)24-20-36)37-21-25-39(58-10)26-22-37/h13-15,17-26,30-33,40,42-43,46H,16,28-29H2,1-12H3,(H,50,51,53,56)/t40-,42-,43-,46-,64?/m1/s1

Synonyms: Adenosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trimethylsilyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; DMT-2'-O-TBDMS-A(Ac)-CE Phosphoramidite; 2'-O-TBDMS-A(Ac) CE Phosphoramidite; (2R,3R,4R,5R)-5-(6-Acetamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-tBDSilyl Adenosine (n-acetyl) CED phosphoramidite

2'-OTBS O6-NPE-I amidite

Description: 2'-OTBS O6-NPE-I amidite is a chemically modified phosphoramidite used in the synthesis of oligonucleotides. This compound features inosine as the nucleoside base, with an O6 position protected by a nitrophenylethyl (NPE) group. Additionally, the ribose sugar is protected at the 2' position with a tert-butyldimethylsilyl (TBS) group. This phosphoramidite is specifically designed for incorporation into DNA or RNA sequences during solid-phase oligonucleotide synthesis. The TBS and NPE protecting groups ensure selective deprotection, allowing for precise modifications of oligonucleotides. This modified amidite is useful in various research applications, including the study of nucleotide interactions, enzymatic processing of modified nucleotides, and the development of therapeutic oligonucleotides, particularly those requiring enhanced stability or specific chemical modifications.

CAT: BRP-00878

CAS: 151059-66-4

Molecular Formula: C54H68N7O10PSi

Molecular Weight: 1034.24

Purity: >98%

Appearance: Off-white solid

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InChIKey: ORFDMMXBXUZNMM-YYONJIEZSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(4-nitrophenethoxy)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H68N7O10PSi/c1-37(2)60(38(3)4)72(68-32-15-31-55)70-48-46(34-67-54(40-16-13-12-14-17-40,41-20-26-44(64-8)27-21-41)42-22-28-45(65-9)29-23-42)69-52(49(48)71-73(10,11)53(5,6)7)59-36-58-47-50(59)56-35-57-51(47)66-33-30-39-18-24-43(25-19-39)61(62)63/h12-14,16-29,35-38,46,48-49,52H,15,30,32-34H2,1-11H3/t46-,48-,49-,52-,72?/m1/s1

Synonyms: 5'-O-DMT-2'-O-TBDMS O6-NPE-I 3'-CE Phosphoramidite

2'-OTBS C(pac) amidite

Description: 2'-OTBS C(Pac) amidite is a specialized compound used in oligonucleotide synthesis. It consists of a nucleoside derivative with a tert-butyldimethylsilyl (OTBS) group protecting the 2'-hydroxyl position of cytidine. Additionally, it features a phenoxyacetyl (Pac) group attached to the amine group of the cytidine base. This compound facilitates controlled addition during oligonucleotide synthesis, enabling precise customization and design of cytidine-modified oligonucleotides for various molecular biology applications, including RNA interference (RNAi) studies, gene expression analysis, and antisense oligonucleotide design.

CAT: BRP-00879

CAS: 259144-69-9

Molecular Formula: C53H68N5O10PSi

Molecular Weight: 994.21

Purity: >98%

Appearance: Off-white solid

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InChIKey: HUTVBXXKUWIFOM-OPZOZVPWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H68N5O10PSi/c1-37(2)58(38(3)4)69(65-34-18-32-54)67-48-45(35-64-53(39-19-14-12-15-20-39,40-23-27-42(61-8)28-24-40)41-25-29-43(62-9)30-26-41)66-50(49(48)68-70(10,11)52(5,6)7)57-33-31-46(56-51(57)60)55-47(59)36-63-44-21-16-13-17-22-44/h12-17,19-31,33,37-38,45,48-50H,18,34-36H2,1-11H3,(H,55,56,59,60)/t45-,48-,49-,50-,69?/m1/s1

Synonyms: 2'-tBDSilyl Cytidine (n-PAC) CED phosphoramidite; 2'-O-TBDMS C(pac) 3'-CE phosphoramidite

2'-OMe O6-NPE-I amidite

Description: 2'-OTBS O6-NPE-I amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of nucleosides modified at the O6 position with NPE (nitrophenylethyl) functionality and protected with tert-butyldimethylsilyl (OTBS) into the oligonucleotide sequence. This compound is important for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00880

Molecular Formula: C49H56N7O10P

Molecular Weight: 934.00

Purity: >95%

Appearance: Off-white solid

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InChIKey: WOXYNKAZRDURES-WBHVIXSUSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-(4-nitrophenethoxy)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H56N7O10P/c1-33(2)55(34(3)4)67(64-28-11-27-50)66-44-42(30-63-49(36-12-9-8-10-13-36,37-16-22-40(59-5)23-17-37)38-18-24-41(60-6)25-19-38)65-48(45(44)61-7)54-32-53-43-46(54)51-31-52-47(43)62-29-26-35-14-20-39(21-15-35)56(57)58/h8-10,12-25,31-34,42,44-45,48H,11,26,28-30H2,1-7H3/t42-,44-,45-,48-,67?/m1/s1

Synonyms: 5'-O-DMT-2'-O-Me O6-NPE-I 3'-CE Phosphoramidite

2'-OMe C(dmf) amidite

Description: 2'-OMe C(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of cytidine residues modified with 2'-methoxy and protected with dimethylformamidine (dmf) into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00881

Molecular Formula: C43H55N6O8P

Molecular Weight: 814.92

Purity: >98%

Appearance: Off-white solid

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InChIKey: ICEAPTWUNIADBV-PENKXTLKSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-2-oxopyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H55N6O8P/c1-30(2)49(31(3)4)58(55-27-13-25-44)57-39-37(56-41(40(39)53-9)48-26-24-38(46-42(48)50)45-29-47(5)6)28-54-43(32-14-11-10-12-15-32,33-16-20-35(51-7)21-17-33)34-18-22-36(52-8)23-19-34/h10-12,14-24,26,29-31,37,39-41H,13,27-28H2,1-9H3/t37-,39-,40-,41-,58?/m1/s1

Synonyms: DMT-2'-O-Me-C(dmf)-CE Phosphoramidite; N4-Dimethylformamide-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl phosphoramidite

2'-OMe A(dmf) amidite

Description: 2'-OMe A(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with 2'-methoxy and protected with dimethylformamidine (dmf) into the oligonucleotide sequence. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00882

Molecular Formula: C44H55N8O7P

Molecular Weight: 838.95

Purity: >97%

Appearance: Off-white solid

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InChIKey: BKDZYCQEULBZAC-OOJSWXONSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-(((dimethylamino)methylene)amino)-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H55N8O7P/c1-30(2)52(31(3)4)60(57-25-13-24-45)59-39-37(58-43(40(39)55-9)51-29-48-38-41(49-28-50(5)6)46-27-47-42(38)51)26-56-44(32-14-11-10-12-15-32,33-16-20-35(53-7)21-17-33)34-18-22-36(54-8)23-19-34/h10-12,14-23,27-31,37,39-40,43H,13,25-26H2,1-9H3/t37-,39-,40-,43-,60?/m1/s1

Synonyms: 2'-OMe A(dmf) phosphoramidite; 2'-OMe-A(dmf) CE-Phosphoramidite; 5'-O-DMTr-2'-O-Methyl-A(dmf)-3'-CE-Phosphoramidite

2'-OMe C(pac) amidite

Description: 2'-OMe C(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of cytidine residues modified with 2'-methoxy and protected with phenoxyacetyl (pac) into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00883

Molecular Formula: C48H56N5O10P

Molecular Weight: 893.98

Purity: >98%

Appearance: Off-white solid

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InChIKey: YHPPPUPQDGDFOB-KPYWRNADSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H56N5O10P/c1-33(2)53(34(3)4)64(61-30-14-28-49)63-44-41(62-46(45(44)58-7)52-29-27-42(51-47(52)55)50-43(54)32-59-40-17-12-9-13-18-40)31-60-48(35-15-10-8-11-16-35,36-19-23-38(56-5)24-20-36)37-21-25-39(57-6)26-22-37/h8-13,15-27,29,33-34,41,44-46H,14,30-32H2,1-7H3,(H,50,51,54,55)/t41-,44-,45-,46-,64?/m1/s1

Synonyms: 2'-OMe C(pac) phosphoramidite; 2'-OMe-C(pac) CE-Phosphoramidite; 2'-O-Methyl Cytidine (n-PAC) CED phosphoramidite; 5'-O-DMTr-2'-O-Methyl-C(Pac)-3'-CE-Phosphoramidite

2'-OMe MeC(pac) amidite

Description: 2'-OMe MeC(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, allowing the incorporation of cytidine residues modified with 2'-methoxy and protected with phenoxyacetyl (pac) into the oligonucleotide sequence. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00884

Molecular Formula: C49H58N5O10P

Molecular Weight: 908.00

Purity: >98%

Appearance: Off-white solid

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InChIKey: NBZIVLMTLZOAQR-NXPFYNPLSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(5-methyl-2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H58N5O10P/c1-33(2)54(34(3)4)65(62-29-15-28-50)64-44-42(63-47(45(44)59-8)53-30-35(5)46(52-48(53)56)51-43(55)32-60-41-18-13-10-14-19-41)31-61-49(36-16-11-9-12-17-36,37-20-24-39(57-6)25-21-37)38-22-26-40(58-7)27-23-38/h9-14,16-27,30,33-34,42,44-45,47H,15,29,31-32H2,1-8H3,(H,51,52,55,56)/t42-,44-,45-,47-,65?/m1/s1

Synonyms: 2'-OMe-MeC(pac) CE-Phosphoramidite

2'-OTFM A(Bz) amidite

Description: 2'-OTFM A(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with 2'-O-trifluoromethyl (2'-OTFM) and protected with benzoyl (Bz) into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00885

CAS: 220322-52-1

Molecular Formula: C48H51F3N7O8P

Molecular Weight: 941.95

Purity: >95%

Appearance: Off-white solid

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InChIKey: LFGLQKDVVQKUSX-OPRMLWSSSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC(F)(F)F)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(trifluoromethoxy)oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C48H51F3N7O8P/c1-31(2)58(32(3)4)67(63-27-13-26-52)66-41-39(28-62-47(34-16-11-8-12-17-34,35-18-22-37(60-5)23-19-35)36-20-24-38(61-6)25-21-36)64-46(42(41)65-48(49,50)51)57-30-55-40-43(53-29-54-44(40)57)56-45(59)33-14-9-7-10-15-33/h7-12,14-25,29-32,39,41-42,46H,13,27-28H2,1-6H3,(H,53,54,56,59)/t39-,41-,42-,46-,67?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trifluoromethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-propargyl G(Ac) amidite

Description: 2'-propargyl G(Ac) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, allowing the incorporation of guanine residues modified with a propargyl group at the 2' position and protected with acetyl (Ac) into the oligonucleotide sequence. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00886

Molecular Formula: C45H52N7O9P

Molecular Weight: 865.93

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: HJFWRIKHRWBAKQ-GDLAVZMWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H52N7O9P/c1-9-25-57-40-39(61-62(59-26-13-24-46)52(29(2)3)30(4)5)37(60-43(40)51-28-47-38-41(51)49-44(48-31(6)53)50-42(38)54)27-58-45(32-14-11-10-12-15-32,33-16-20-35(55-7)21-17-33)34-18-22-36(56-8)23-19-34/h1,10-12,14-23,28-30,37,39-40,43H,13,25-27H2,2-8H3,(H2,48,49,50,53,54)/t37-,39-,40-,43-,62?/m1/s1

Synonyms: N2-Ac-DMT-2'-O-propargyl-G-CE-Phosphoramidite; [N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-guanosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

2'-propargyl A(pac) amidite

Description: 2'-propargyl A(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with a propargyl group at the 2' position and protected with pac (phenoxyacetyl) into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00887

Molecular Formula: C51H56N7O9P

Molecular Weight: 942.02

Purity: >95%

Appearance: Off-white solid

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InChIKey: IACAIOROZYTJFW-KJMRTUCVSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H56N7O9P/c1-8-29-62-47-46(67-68(65-30-15-28-52)58(35(2)3)36(4)5)43(66-50(47)57-34-55-45-48(53-33-54-49(45)57)56-44(59)32-63-42-18-13-10-14-19-42)31-64-51(37-16-11-9-12-17-37,38-20-24-40(60-6)25-21-38)39-22-26-41(61-7)27-23-39/h1,9-14,16-27,33-36,43,46-47,50H,15,29-32H2,2-7H3,(H,53,54,56,59)/t43-,46-,47-,50-,68?/m1/s1

Synonyms: 2'-propargyl-Pac-A-CE Phosphoramidite

2'-OTBS A(di-Me) amidite

Description: 2'-OTBS A(di-Me) amidite is commonly used in the synthesis of RNA molecules through solid-phase synthesis. This phosphoramidite derivative contains a 2'-O-TBDMS (tert-butyldimethylsilyl) and a 3'-O-CE (2-cyanoethyl) protecting groups, which can be removed under specific conditions after synthesis. The N6,N6-Dimethyl modification on the adenine base can also enhance the specificity and selectivity of RNA interactions with target molecules. This modified adenosine derivative can improve the stability and binding affinity of RNA molecules in various applications such as antisense therapy, RNA interference, and aptamer development.

CAT: BRP-00888

Molecular Formula: C48H66N7O7PSi

Molecular Weight: 912.16

Purity: >95%

Appearance: Off-white solid

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InChIKey: FOBJTSYXSOCKFB-OKNPHDNFSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(dimethylamino)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H66N7O7PSi/c1-33(2)55(34(3)4)63(59-29-17-28-49)61-42-40(60-46(43(42)62-64(12,13)47(5,6)7)54-32-52-41-44(53(8)9)50-31-51-45(41)54)30-58-48(35-18-15-14-16-19-35,36-20-24-38(56-10)25-21-36)37-22-26-39(57-11)27-23-37/h14-16,18-27,31-34,40,42-43,46H,17,29-30H2,1-13H3/t40-,42-,43-,46-,63?/m1/s1

Synonyms: N6,N6-Dimethyl Adenosine 2'-TBDMS-3'-CEP; N6,N6-Dimethyl 2'-TBDMS rA 3'-CE phosphoramidite

2'-OTBS N1-Me-A(ClAc) amidite

Description: 2'-OTBS N1-Me-A(ClAc) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with a methyl group at the N1 position and protected with chloroacetyl (ClAc) at the amino group into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00889

Molecular Formula: C49H65ClN7O8PSi

Molecular Weight: 974.61

Purity: >95%

Appearance: Off-white solid

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InChIKey: ISUKAHYBQLYEAJ-VPFLNFIBSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-((2-chloroacetyl)imino)-1-methyl-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H65ClN7O8PSi/c1-33(2)57(34(3)4)66(62-28-16-27-51)64-43-40(30-61-49(35-17-14-13-15-18-35,36-19-23-38(59-9)24-20-36)37-21-25-39(60-10)26-22-37)63-47(44(43)65-67(11,12)48(5,6)7)56-32-52-42-45(56)53-31-55(8)46(42)54-41(58)29-50/h13-15,17-26,31-34,40,43-44,47H,16,28-30H2,1-12H3/t40-,43-,44-,47-,66?/m1/s1

Synonyms: 5'-O-DMT-2'-O-TBDMS N1-Me-A(ClAc) 3'-CE Phosphoramidite

2'-OTBS 7De8a-A(dmf) amidite

Description: 2'-OTBS 7De8a-A(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with a 7-deaza-8-azaadenine (7De8a) nucleoside and protected with dimethylformamidine (dmf) into the oligonucleotide sequence. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00890

Molecular Formula: C49H67N8O7PSi

Molecular Weight: 939.18

Purity: >95%

Appearance: Off-white solid

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InChIKey: FFFMJLRLMAOUHM-NWPXMRGSSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-(((dimethylamino)methylene)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H67N8O7PSi/c1-34(2)57(35(3)4)65(61-29-17-28-50)63-43-42(31-60-49(36-18-15-14-16-19-36,37-20-24-39(58-10)25-21-37)38-22-26-40(59-11)27-23-38)62-47(44(43)64-66(12,13)48(5,6)7)56-46-41(30-54-56)45(51-32-52-46)53-33-55(8)9/h14-16,18-27,30,32-35,42-44,47H,17,29,31H2,1-13H3/t42-,43-,44-,47-,65?/m1/s1

Synonyms: 5'-O-DMT-2'-O-TBDMS 7De8a-A(dmf) 3'-CE Phosphoramidite

PHT PEG3 amidite

Description: PHT PEG3 amidite is a modified phosphoramidite used in oligonucleotide synthesis. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00891

CAS: 2170381-91-4

Molecular Formula: C23H34N3O7P

Molecular Weight: 495.51

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: UDTLXDXACDJZQQ-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(N(C(C)C)P(OCCC#N)OCCOCCOCCON(C(C1=C2C=CC=C1)=O)C2=O)C

IUPAC Name: 2-cyanoethyl (2-(2-(2-((1,3-dioxoisoindolin-2-yl)oxy)ethoxy)ethoxy)ethyl) diisopropylphosphoramidite

InChI: InChI=1S/C23H34N3O7P/c1-18(2)26(19(3)4)34(32-11-7-10-24)33-17-15-30-13-12-29-14-16-31-25-22(27)20-8-5-6-9-21(20)23(25)28/h5-6,8-9,18-19H,7,11-17H2,1-4H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[2-[2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]ethoxy]ethoxy]ethyl ester

PHT PEG4 amidite

Description: PHT PEG4 amidite is a modified phosphoramidite utilized in oligonucleotide synthesis. This compound is vital for the creation of oligonucleotides with tailored modifications, which find applications across molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00892

CAS: 539820-47-8

Molecular Formula: C25H38N3O8P

Molecular Weight: 539.57

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: GRCXVBYRTJTFCI-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCON1C(=O)C2=CC=CC=C2C1=O

IUPAC Name: 3-[2-[2-[2-[2-(1,3-dioxoisoindol-2-yl)oxyethoxy]ethoxy]ethoxy]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C25H38N3O8P/c1-20(2)28(21(3)4)37(35-11-7-10-26)36-19-17-33-15-13-31-12-14-32-16-18-34-27-24(29)22-8-5-6-9-23(22)25(27)30/h5-6,8-9,20-21H,7,11-19H2,1-4H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[2-[2-[2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]ethoxy]ethoxy]ethoxy]ethyl ester; 2-cyanoethyl (2-(2-(2-(2-((1,3-dioxoisoindolin-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl) diisopropylphosphoramidite

Cyanoethoxycarbonyl C6 amine amidite

Description: Cyanoethoxycarbonyl C6 amine amidite is a modified phosphoramidite used in oligonucleotide synthesis. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00893

CAS: 242147-85-9

Molecular Formula: C19H35N4O4P

Molecular Weight: 414.49

Purity: >98%

Appearance: Light-yellow oily matter

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InChIKey: OXPJJHKDHVDTKR-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)OCCC#N)OCCC#N

IUPAC Name: 2-cyanoethyl N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]carbamate

InChI: InChI=1S/C19H35N4O4P/c1-17(2)23(18(3)4)28(27-16-10-12-21)26-15-8-6-5-7-13-22-19(24)25-14-9-11-20/h17-18H,5-10,13-16H2,1-4H3,(H,22,24)

Synonyms: 2-cyanoethyl (6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamate

Cbz C2 amine amidite

Description: Cbz C2 amine amidite is a modified phosphoramidite used in oligonucleotide synthesis. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00894

CAS: 133339-58-9

Molecular Formula: C19H30N3O4P

Molecular Weight: 395.44

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: BFXBTPRPHVBFNA-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCNC(=O)OCC1=CC=CC=C1

IUPAC Name: benzyl N-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethyl]carbamate

InChI: InChI=1S/C19H30N3O4P/c1-16(2)22(17(3)4)27(25-13-8-11-20)26-14-12-21-19(23)24-15-18-9-6-5-7-10-18/h5-7,9-10,16-17H,8,12-15H2,1-4H3,(H,21,23)

Synonyms: 5-Oxa-2,7-diaza-6-phosphanonanoic acid, 6-(2-cyanoethoxy)-8-methyl-7-(1-methylethyl)-, phenylmethyl ester; benzyl (2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethyl)carbamate

Cbz C6 amine amidite

Description: Cbz C6 amine amidite is a modified phosphoramidite used in oligonucleotide synthesis. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00895

CAS: 1235579-76-6

Molecular Formula: C23H38N3O4P

Molecular Weight: 451.55

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: DEWXQEGATRHNSP-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)OCC1=CC=CC=C1)OCCC#N

IUPAC Name: benzyl N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]carbamate

InChI: InChI=1S/C23H38N3O4P/c1-20(2)26(21(3)4)31(30-18-12-15-24)29-17-11-6-5-10-16-25-23(27)28-19-22-13-8-7-9-14-22/h7-9,13-14,20-21H,5-6,10-12,16-19H2,1-4H3,(H,25,27)

Synonyms: 9-Oxa-2,11-diaza-10-phosphatridecanoic acid, 10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-, phenylmethyl ester; benzyl (6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamate

2'-OPivOM A(pac) amidite

2'-OTBS A(Ac) amidite

2'-OTBS O6-NPE-I amidite

2'-OTBS C(pac) amidite

2'-OMe O6-NPE-I amidite

2'-OMe C(dmf) amidite

2'-OMe A(dmf) amidite

2'-OMe C(pac) amidite

2'-OMe MeC(pac) amidite

2'-OTFM A(Bz) amidite

2'-propargyl G(Ac) amidite

2'-propargyl A(pac) amidite

2'-OTBS A(di-Me) amidite

2'-OTBS N1-Me-A(ClAc) amidite

2'-OTBS 7De8a-A(dmf) amidite

PHT PEG3 amidite

PHT PEG4 amidite

Cyanoethoxycarbonyl C6 amine amidite

Cbz C2 amine amidite

Cbz C6 amine amidite

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