What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

C8 amidite

Description: C8 amidite is a linker used in oligonucleotide synthesis. This linker provides a connection between the oligonucleotide and other molecules or surfaces during synthesis or conjugation processes. The ''C8'' designation indicates that it consists of a linker with an 8-carbon chain length. This linker facilitates the attachment of oligonucleotides to various molecules or surfaces, enabling specific applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in bioassays.

CAT: BRP-00961

CAS: 194015-05-9

Molecular Formula: C17H35N2O2P

Molecular Weight: 330.45

Purity: >98%

Appearance: Light-yellow oily matter

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InChIKey: SYIZTDJMSOSVGQ-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CCCCCCCCOP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-octoxyphosphanyl]oxypropanenitrile

InChI: InChI=1S/C17H35N2O2P/c1-6-7-8-9-10-11-14-20-22(21-15-12-13-18)19(16(2)3)17(4)5/h16-17H,6-12,14-15H2,1-5H3

Synonyms: 2-Cyanoethyl octyl diisopropylphosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl octyl ester; O-β-Cyanoethyl-O-octyl-N,N-diisopropyl phosphoramidite

C11 amidite

Description: C11 amidite is a linker used in oligonucleotide synthesis, consisting of an 11-carbon chain length. This linker facilitates the connection between the oligonucleotide and other molecules or surfaces during synthesis or conjugation processes. It provides flexibility and space between the oligonucleotide and the attached moiety, enabling various applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in bioassays.

CAT: BRP-00962

CAS: 125676-85-9

Molecular Formula: C20H41N2O2P

Molecular Weight: 372.53

Purity: >98%

Appearance: Light-yellow oily matter

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InChIKey: IJPKCIKPYVOSEV-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCCCCCC)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl undecyl diisopropylphosphoramidite

InChI: InChI=1S/C20H41N2O2P/c1-6-7-8-9-10-11-12-13-14-17-23-25(24-18-15-16-21)22(19(2)3)20(4)5/h19-20H,6-15,17-18H2,1-5H3

Synonyms: 2-Cyanoethyl undecyl diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl undecyl ester; 2-Cyanoethyl undecyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl undecyl ester

C14 amidite

Description: C14 amidite is a linker utilized in oligonucleotide synthesis, featuring a 14-carbon chain length. This linker serves to connect the oligonucleotide to other molecules or surfaces during synthesis or conjugation processes. The ''C14'' designation indicates the length of the carbon chain in the linker. It provides flexibility and space between the oligonucleotide and the attached moiety, facilitating specific applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in various bioassays.

CAT: BRP-00963

CAS: 198987-41-6

Molecular Formula: C23H47N2O2P

Molecular Weight: 414.62

Purity: >98%

Appearance: Light-yellow oily matter

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InChIKey: BGMXNCIZEALUBC-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CCCCCCCCCCCCCCOP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-tetradecoxyphosphanyl]oxypropanenitrile

InChI: InChI=1S/C23H47N2O2P/c1-6-7-8-9-10-11-12-13-14-15-16-17-20-26-28(27-21-18-19-24)25(22(2)3)23(4)5/h22-23H,6-18,20-21H2,1-5H3

Synonyms: 2-Cyanoethyl tetradecyl diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl tetradecyl ester; 2-Cyanoethyl tetradecyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl tetradecyl ester

11-Br-C11 amidite

Description: 11-Br-C11 amidite is a reagent used in oligonucleotide synthesis, featuring an 11-carbon chain length with a bromine (Br) atom. This linker allows for the attachment of oligonucleotides to other molecules or surfaces during synthesis or conjugation processes. The bromine atom provides a reactive site for further functionalization or coupling reactions. It provides flexibility and space between the oligonucleotide and the attached moiety, enabling specific applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in various bioassays.

CAT: BRP-00964

CAS: 804567-08-6

Molecular Formula: C20H40BrN2O2P

Molecular Weight: 451.43

Purity: >98%

Appearance: Light-yellow oily matter

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InChIKey: MZMSOHBMQFZJNM-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCCCCCCBr)N(C(C)C)C(C)C

IUPAC Name: 11-bromoundecyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C20H40BrN2O2P/c1-19(2)23(20(3)4)26(25-18-14-16-22)24-17-13-11-9-7-5-6-8-10-12-15-21/h19-20H,5-15,17-18H2,1-4H3

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 11-bromoundecyl 2-cyanoethyl ester

2'-O-NMA PseudoUridine amidite

Description: 2'-O-NMA PseudoUridine amidite is a reagent used in oligonucleotide synthesis, featuring a modification at the 2' position of ribose with N-methylaminomethylene (NMA) and incorporating a pseudo-uridine moiety. This reagent enables the synthesis of oligonucleotides containing pseudo-uridine modifications, which can confer specific properties or functionalities to the resulting oligonucleotides. PseudoUridine modifications are valuable for applications in biotechnology and therapeutics due to their potential to enhance stability, specificity, or other desired characteristics.

CAT: BRP-00965

Molecular Formula: C42H52N5O10P

Molecular Weight: 817.88

Purity: >95%

Appearance: Off-white solid

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InChIKey: NHSKCVXWHUBLRO-AZUJSHLHSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H52N5O10P/c1-27(2)47(28(3)4)58(55-23-11-22-43)57-38-35(56-37(39(38)53-26-36(48)44-5)34-24-45-41(50)46-40(34)49)25-54-42(29-12-9-8-10-13-29,30-14-18-32(51-6)19-15-30)31-16-20-33(52-7)21-17-31/h8-10,12-21,24,27-28,35,37-39H,11,23,25-26H2,1-7H3,(H,44,48)(H2,45,46,49,50)/t35-,37+,38-,39+,58?/m1/s1

2'-O-NMA N1-Methyl PseudoUridine amidite

Description: 2'-O-NMA N1-Methyl PseudoUridine amidite is a reagent employed in oligonucleotide synthesis. It involves a modification at the 2' position of ribose with N-methylaminomethylene (NMA) and incorporates N1-Methyl PseudoUridine, a modified nucleoside resembling uridine with a methyl group attached to the nitrogen at position 1. This reagent enables the synthesis of oligonucleotides with N1-Methyl PseudoUridine modifications, offering specific properties or functionalities to the resulting oligonucleotides. These modifications can be advantageous for various biotechnological and therapeutic applications, providing enhanced stability or other desired characteristics.

CAT: BRP-00966

Molecular Formula: C43H54N5O10P

Molecular Weight: 831.90

Purity: >95%

Appearance: Off-white solid

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InChIKey: PRKXXSDXURDTSF-ZIVCPKBRSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H54N5O10P/c1-28(2)48(29(3)4)59(56-24-12-23-44)58-39-36(57-38(40(39)54-27-37(49)45-5)35-25-47(6)42(51)46-41(35)50)26-55-43(30-13-10-9-11-14-30,31-15-19-33(52-7)20-16-31)32-17-21-34(53-8)22-18-32/h9-11,13-22,25,28-29,36,38-40H,12,24,26-27H2,1-8H3,(H,45,49)(H,46,50,51)/t36-,38+,39-,40+,59?/m1/s1

2'-OEt-S-S-tBu C(Bz) amidite

Description: 2'-OEt-S-S-tBu C(Bz) amidite is a reagent used in oligonucleotide synthesis, containing a disulfide linkage with tert-butyl (tBu) termination and cytosine protected with benzoyl (Bz) group at the 2' position of ribose. This modification allows for the introduction of reversible crosslinking or enhanced stability properties to the resulting oligonucleotides.

CAT: BRP-00967

CAS: 176747-35-6

Molecular Formula: C52H64N5O9PS2

Molecular Weight: 998.22

Purity: >95%

Appearance: Off-white solid

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InChIKey: GGJPSSSMERVJTA-YOVDOAOFSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OCCSSC(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-(tert-butyldisulfaneyl)ethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H64N5O9PS2/c1-36(2)57(37(3)4)67(64-32-16-30-53)66-46-44(35-63-52(39-19-14-11-15-20-39,40-21-25-42(60-8)26-22-40)41-23-27-43(61-9)28-24-41)65-49(47(46)62-33-34-68-69-51(5,6)7)56-31-29-45(55-50(56)59)54-48(58)38-17-12-10-13-18-38/h10-15,17-29,31,36-37,44,46-47,49H,16,32-35H2,1-9H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[2-[(1,1-dimethylethyl)dithio]ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Thio(Bz) C6 amidite

Description: Thio(Bz) C6 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with a benzoyl (Bz) protecting group and a 6-carbon linker. This reagent allows for the introduction of a thiol-modified linker with a 6-carbon chain length into oligonucleotide sequences during synthesis. Thiol modifications can be employed for various applications such as covalent conjugation, labeling, or surface immobilization in bioassays.

CAT: BRP-00968

CAS: 176640-52-1

Molecular Formula: C22H35N2O3PS

Molecular Weight: 438.57

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: UDUVXNZCIKTQTP-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCSC(=O)C=1C=CC=CC1)N(C(C)C)C(C)C

IUPAC Name: S-(6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl) benzothioate

InChI: InChI=1S/C22H35N2O3PS/c1-19(2)24(20(3)4)28(27-17-12-15-23)26-16-10-5-6-11-18-29-22(25)21-13-8-7-9-14-21/h7-9,13-14,19-20H,5-6,10-12,16-18H2,1-4H3

Synonyms: Benzenecarbothioic acid, S-[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ester; S-[6-[[[Bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] benzenecarbothioate

Thio(Ac) C6 amidite

Description: Thio(Ac) C6 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with an acetyl (Ac) protecting group and a 6-carbon linker. This reagent enables the introduction of a thiol-modified linker with a 6-carbon chain length into oligonucleotide sequences during synthesis. Thiol modifications can be utilized for various applications such as covalent conjugation, labeling, or surface immobilization in bioassays.

CAT: BRP-00969

CAS: 176640-51-0

Molecular Formula: C17H33N2O3PS

Molecular Weight: 376.50

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: YYZTVJUOQPJPLL-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCSC(=O)C)N(C(C)C)C(C)C

IUPAC Name: S-(6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl) ethanethioate

InChI: InChI=1S/C17H33N2O3PS/c1-15(2)19(16(3)4)23(22-13-10-11-18)21-12-8-6-7-9-14-24-17(5)20/h15-16H,6-10,12-14H2,1-5H3

Synonyms: Ethanethioic acid, S-[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ester; S-[6-[[[Bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ethanethioate

Thio(Ac)-PEG3 amidite

Description: Thio(Ac)-PEG3 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with an acetyl (Ac) protecting group and a polyethylene glycol (PEG) linker of three ethylene glycol units. This reagent allows for the introduction of a thiol-modified linker with a PEG3 spacer into oligonucleotide sequences during synthesis. Thiol modifications with PEG linkers are often employed for various applications such as covalent conjugation, labeling, or improving solubility and flexibility of oligonucleotides.

CAT: BRP-00970

CAS: 153870-21-4

Molecular Formula: C17H33N2O5PS

Molecular Weight: 408.50

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: FMIVUFGXNQLSTH-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCSC(=O)C

IUPAC Name: S-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethyl] ethanethioate

InChI: InChI=1S/C17H33N2O5PS/c1-15(2)19(16(3)4)25(23-8-6-7-18)24-12-11-21-9-10-22-13-14-26-17(5)20/h15-16H,6,8-14H2,1-5H3

Synonyms: Ethanethioic acid, S-[10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-3,6,9-trioxa-11-aza-10-phosphatridec-1-yl] ester; Ethanethioic acid, S-[10-[bis(1-methylethyl)amino]-13-cyano-3,6,9,11-tetraoxa-10-phosphatridec-1-yl] ester; S-[10-(2-Cyanoethoxy)-12-methyl-11-(1-methylethyl)-3,6,9-trioxa-11-aza-10-phosphatridec-1-yl] ethanethioate; S-(2-(2-(2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethoxy)ethyl) ethanethioate

UNA 2'-OBz C(Bz) amidite

Description: UNA 2'-OBz C(Bz) amidite is a reagent used in oligonucleotide synthesis, containing an Unlocked Nucleic Acid (UNA) backbone modification. In this designation, 2'-OBz indicates a benzoyl (Bz) protecting group at the 2' position of ribose, and C(Bz) indicates cytosine (C) protected with a benzoyl group. This reagent is utilized for synthesizing oligonucleotides with UNA backbone modifications, which increase the flexibility of the oligonucleotide backbone. UNA modifications can confer specific properties to oligonucleotides, such as altering hybridization behavior or enhancing nuclease resistance, suitable for various biotechnological applications.

CAT: BRP-00971

Molecular Formula: C53H58N5O10P

Molecular Weight: 956.05

Purity: >95%

Appearance: Off-white solid

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InChIKey: MINLZVSGJNTMMR-OBHWIOKQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R)-2-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(((2R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propan-2-yl)oxy)ethyl benzoate

InChI: InChI=1S/C53H58N5O10P/c1-38(2)58(39(3)4)69(66-34-16-32-54)67-36-47(35-65-53(42-21-14-9-15-22-42,43-23-27-45(62-5)28-24-43)44-25-29-46(63-6)30-26-44)68-49(37-64-51(60)41-19-12-8-13-20-41)57-33-31-48(56-52(57)61)55-50(59)40-17-10-7-11-18-40/h7-15,17-31,33,38-39,47,49H,16,34-37H2,1-6H3,(H,55,56,59,61)/t47-,49-,69?/m1/s1

Synonyms: N6-Bz-C-UNA-Phosphoramidite; 2'-OBz-N6-Bz-C-UNA-Phosphoramidite; 2'-OBz-C(Bz)-UNA-Phosphoramidite; 2'-OBz-C(Bz)-UNA-3'-CE-Phosphoramidite

2'-MOE PseudoUridine amidite

Description: 2'-MOE PseudoUridine amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates PseudoUridine, a modified nucleoside resembling uridine. This allows for the synthesis of oligonucleotides containing PseudoUridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.

CAT: BRP-00972

CAS: 1417162-48-1

Molecular Formula: C42H53N4O10P

Molecular Weight: 804.88

Purity: >95%

Appearance: Off-white solid

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InChIKey: QGENAASPFJKDDU-APSGJOCZSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(C2=CNC(=O)NC2=O)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H53N4O10P/c1-28(2)46(29(3)4)57(54-23-11-22-43)56-38-36(55-37(39(38)52-25-24-49-5)35-26-44-41(48)45-40(35)47)27-53-42(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-21,26,28-29,36-39H,11,23-25,27H2,1-7H3,(H2,44,45,47,48)/t36-,37+,38-,39+,57?/m1/s1

Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-(2-methoxyethyl)-β-D-ribofuranosyl]-; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-(2-methoxyethyl)-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione

2'-MOE N1-Methyl PseudoUridine amidite

Description: 2'-MOE N1-Methyl PseudoUridine amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates N1-Methyl PseudoUridine, a modified nucleoside resembling uridine with a methyl group attached to the nitrogen at position 1. It enables the synthesis of oligonucleotides containing N1-Methyl PseudoUridine modifications, offering specific properties or functionalities to the resulting oligonucleotides, suitable for various biotechnological applications.

CAT: BRP-00973

Molecular Formula: C43H55N4O10P

Molecular Weight: 818.91

Purity: >95%

Appearance: Off-white solid

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InChIKey: FWVPZDATJBTJIH-SAAFSQBVSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H55N4O10P/c1-29(2)47(30(3)4)58(55-24-12-23-44)57-39-37(56-38(40(39)53-26-25-50-6)36-27-46(5)42(49)45-41(36)48)28-54-43(31-13-10-9-11-14-31,32-15-19-34(51-7)20-16-32)33-17-21-35(52-8)22-18-33/h9-11,13-22,27,29-30,37-40H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38+,39-,40+,58?/m1/s1

2'-OMe 5-Ethynyl-U amidite

Description: 2'-OMe 5-Ethynyl-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates 5-Ethynyl-Uridine (5-Ethynyl-U), a modified uridine nucleoside with an ethynyl group attached at the 5-position of the uracil base. It allows for the synthesis of oligonucleotides containing 5-Ethynyl-Uridine modifications, which can be useful for various applications such as click chemistry reactions for further functionalization or conjugation.

CAT: BRP-00974

CAS: 2201814-30-2

Molecular Formula: C42H49N4O9P

Molecular Weight: 784.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: FTWDORGUPXUAIL-WDABSCDASA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C#C)C(=O)NC2=O)C1OC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-ethynyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H49N4O9P/c1-9-30-26-45(41(48)44-39(30)47)40-38(51-8)37(55-56(53-25-13-24-43)46(28(2)3)29(4)5)36(54-40)27-52-42(31-14-11-10-12-15-31,32-16-20-34(49-6)21-17-32)33-18-22-35(50-7)23-19-33/h1,10-12,14-23,26,28-29,36-38,40H,13,25,27H2,2-8H3,(H,44,47,48)/t36-,37-,38-,40-,56?/m1/s1

2'-MOE 2-Thio-U amidite

Description: 2'-MOE 2-Thio-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates 2-Thio-Uridine (2-Thio-U), a modified uridine nucleoside with a sulfur atom (S) at the 2-position of the uracil base. It facilitates the synthesis of oligonucleotides containing 2-Thio-Uridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.

CAT: BRP-00975

CAS: 647839-25-6

Molecular Formula: C42H53N4O9PS

Molecular Weight: 820.95

Purity: >95%

Appearance: Off-white solid

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InChIKey: PRCKCMMLZPXTNK-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=CC(=O)NC2=S)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H53N4O9PS/c1-29(2)46(30(3)4)56(53-25-11-23-43)55-38-36(54-40(39(38)51-27-26-48-5)45-24-22-37(47)44-41(45)57)28-52-42(31-12-9-8-10-13-31,32-14-18-34(49-6)19-15-32)33-16-20-35(50-7)21-17-33/h8-10,12-22,24,29-30,36,38-40H,11,25-28H2,1-7H3,(H,44,47,57)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-OMe 2-Thio-U amidite

Description: 2'-OMe 2-Thio-U amidite is a reagent employed in oligonucleotide synthesis. This reagent features a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates 2-Thio-Uridine (2-Thio-U), which is a modified uridine nucleoside with a sulfur atom (S) at the 2-position of the uracil base. It enables the synthesis of oligonucleotides containing 2-Thio-Uridine modifications. These modifications can confer specific properties or functionalities to the resulting oligonucleotides, suitable for various applications in biotechnology and molecular biology.

CAT: BRP-00976

CAS: 302918-84-9

Molecular Formula: C40H49N4O8PS

Molecular Weight: 776.89

Purity: >95%

Appearance: Off-white solid

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InChIKey: DWDMFECIJNQDJC-GFIGKZKCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=S)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H49N4O8PS/c1-27(2)44(28(3)4)53(50-25-11-23-41)52-36-34(51-38(37(36)48-7)43-24-22-35(45)42-39(43)54)26-49-40(29-12-9-8-10-13-29,30-14-18-32(46-5)19-15-30)31-16-20-33(47-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,54)/t34-,36-,37-,38-,53?/m1/s1

Synonyms: 2'-O-Me-2-thio-U-3'-phosphoramidite; 2'-O-Me-s2U-3'-[2-cyanoethyl-N,N-diisopropylphosphoramidite]; 5'-O-DMTr-2'-O-methyl-2-thiouridine-3'-CED-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-2-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Me-2-thiouridine-3'-CE-Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyl-2-thiouridine-3'-cyanoethyl Phosphoramidite

2'-OTBS 5-CMOM-U amidite

Description: 2'-OTBS 5-CMOM-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-tert-butyldimethylsilyl (OTBS) and incorporates 5-CMOM-Uridine (5-CMOM-U). It allows for the synthesis of oligonucleotides containing 5-CMOM-Uridine modifications, which can be useful for various applications in oligonucleotide chemistry and nucleic acid research.

CAT: BRP-00977

CAS: 321991-69-9

Molecular Formula: C48H65N4O11PSi

Molecular Weight: 933.13

Purity: >95%

Appearance: Off-white solid

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InChIKey: LBQONPUJFDFCPG-ZHVPLOFZSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)CC(=O)OC)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: methyl 2-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]acetate

InChI: InChI=1S/C48H65N4O11PSi/c1-32(2)52(33(3)4)64(60-28-16-27-49)62-42-40(61-45(43(42)63-65(11,12)47(5,6)7)51-30-34(29-41(53)58-10)44(54)50-46(51)55)31-59-48(35-17-14-13-15-18-35,36-19-23-38(56-8)24-20-36)37-21-25-39(57-9)26-22-37/h13-15,17-26,30,32-33,40,42-43,45H,16,28-29,31H2,1-12H3,(H,50,54,55)/t40-,42-,43-,45-,64?/m1/s1

Synonyms: methyl 2-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate; 5-Pyrimidineacetic acid, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-1,2,3,4-tetrahydro-2,4-dioxo-, methyl ester; Methyl 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidineacetate

2'-OTBS 5,6-dihydro-U amidite

Description: 2'-OTBS 5,6-dihydro-U amidite is a compound used in oligonucleotide synthesis. It features protective groups (DMTr and TBDMS) for the 5'- and 2'-hydroxyl groups, respectively, and a 5,6-dihydrouridine modification. Additionally, it contains a 3'-cyanoethyl (CE) phosphoramidite group for incorporation into oligonucleotide chains during synthesis.

CAT: BRP-00978

CAS: 126684-14-8

Molecular Formula: C45H63N4O9PSi

Molecular Weight: 863.08

Purity: >98%

Appearance: Off-white solid

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InChIKey: DJGPHGMBOQJJIE-ZMHKPELYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2CCC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxo-1,3-diazinan-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H63N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-40-38(56-42(48-28-26-39(50)47-43(48)51)41(40)58-60(10,11)44(5,6)7)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-25,31-32,38,40-42H,15,26,28-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5,6-dihydro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5,6-dihydro-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMTr-2'-O-TBDMS-5,6-dihydrouridine-3'-CE-Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-5,6-dihydrouridine-3'-cyanoethyl Phosphoramidite; 5,6-dihydrouridine-2'-TBDMS-5'-DMT 3'-CED phosphoramidite

2'-OTBS 5-PivOM-U amidite

Description: 2'-OTBS 5-PivOM-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-tert-butyldimethylsilyl (OTBS) and incorporates 5-PivOM-Uridine (5-PivOM-U), a modified uridine nucleoside with a 5'-O-(pivaloyloxymethyl) (PivOM) protecting group attached at the 5-position of the uracil base. It enables the synthesis of oligonucleotides containing 5-PivOM-Uridine modifications, which can be useful for various applications in oligonucleotide chemistry and nucleic acid research.

CAT: BRP-00979

CAS: 2087953-37-3

Molecular Formula: C51H71N4O11PSi

Molecular Weight: 975.21

Purity: >95%

Appearance: Off-white solid

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InChIKey: DJJDOAIVIHEKMZ-GXXQHJQMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=O)NC2=O)COC(=O)C(C)(C)C)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl pivalate

InChI: InChI=1S/C51H71N4O11PSi/c1-34(2)55(35(3)4)67(63-30-18-29-52)65-43-42(33-62-51(37-19-16-15-17-20-37,38-21-25-40(59-11)26-22-38)39-23-27-41(60-12)28-24-39)64-46(44(43)66-68(13,14)50(8,9)10)54-31-36(45(56)53-48(54)58)32-61-47(57)49(5,6)7/h15-17,19-28,31,34-35,42-44,46H,18,30,32-33H2,1-14H3,(H,53,56,58)/t42-,43-,44-,46-,67?/m1/s1

2'-OTBS 5-(3''-amino(TFA)-propynyl)-U amidite

Description: 2'-OTBS 5-(3''-amino(TFA)-propynyl)-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-tert-butyldimethylsilyl (OTBS) and incorporates 5-(3''-amino(TFA)-propynyl)-Uridine, which consists of a propynyl linker with an amino group modified with trifluoroacetic acid (TFA) protection, attached at the 5-position of the uracil base. It allows for the synthesis of oligonucleotides containing this specific modification, which can be useful for various applications such as conjugation, labeling, or functionalization of oligonucleotides.

CAT: BRP-00980

CAS: 1269413-23-1

Molecular Formula: C50H63F3N5O10PSi

Molecular Weight: 1010.13

Purity: >95%

Appearance: Off-white solid

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InChIKey: WJZHTBADFQJCHH-UETLZWTDSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C#CCNC(=O)C(F)(F)F)C(=O)NC2=O)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-5-(3-(2,2,2-trifluoroacetamido)prop-1-yn-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H63F3N5O10PSi/c1-33(2)58(34(3)4)69(65-30-16-28-54)67-42-41(32-64-49(36-18-13-12-14-19-36,37-20-24-39(62-8)25-21-37)38-22-26-40(63-9)27-23-38)66-45(43(42)68-70(10,11)48(5,6)7)57-31-35(44(59)56-47(57)61)17-15-29-55-46(60)50(51,52)53/h12-14,18-27,31,33-34,41-43,45H,16,29-30,32H2,1-11H3,(H,55,60)(H,56,59,61)/t41-,42-,43-,45-,69?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]