Phosphoramidites

2'-O-NMA PseudoUridine amidite

Description: 2'-O-NMA PseudoUridine amidite is a reagent used in oligonucleotide synthesis, featuring a modification at the 2' position of ribose with N-methylaminomethylene (NMA) and incorporating a pseudo-uridine moiety. This reagent enables the synthesis of oligonucleotides containing pseudo-uridine modifications, which can confer specific properties or functionalities to the resulting oligonucleotides. PseudoUridine modifications are valuable for applications in biotechnology and therapeutics due to their potential to enhance stability, specificity, or other desired characteristics.

CAT: BRP-00965

Molecular Formula: C42H52N5O10P

Molecular Weight: 817.88

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: NHSKCVXWHUBLRO-AZUJSHLHSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H52N5O10P/c1-27(2)47(28(3)4)58(55-23-11-22-43)57-38-35(56-37(39(38)53-26-36(48)44-5)34-24-45-41(50)46-40(34)49)25-54-42(29-12-9-8-10-13-29,30-14-18-32(51-6)19-15-30)31-16-20-33(52-7)21-17-31/h8-10,12-21,24,27-28,35,37-39H,11,23,25-26H2,1-7H3,(H,44,48)(H2,45,46,49,50)/t35-,37+,38-,39+,58?/m1/s1

2'-O-NMA N1-Methyl PseudoUridine amidite

Description: 2'-O-NMA N1-Methyl PseudoUridine amidite is a reagent employed in oligonucleotide synthesis. It involves a modification at the 2' position of ribose with N-methylaminomethylene (NMA) and incorporates N1-Methyl PseudoUridine, a modified nucleoside resembling uridine with a methyl group attached to the nitrogen at position 1. This reagent enables the synthesis of oligonucleotides with N1-Methyl PseudoUridine modifications, offering specific properties or functionalities to the resulting oligonucleotides. These modifications can be advantageous for various biotechnological and therapeutic applications, providing enhanced stability or other desired characteristics.

CAT: BRP-00966

Molecular Formula: C43H54N5O10P

Molecular Weight: 831.90

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: PRKXXSDXURDTSF-ZIVCPKBRSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H54N5O10P/c1-28(2)48(29(3)4)59(56-24-12-23-44)58-39-36(57-38(40(39)54-27-37(49)45-5)35-25-47(6)42(51)46-41(35)50)26-55-43(30-13-10-9-11-14-30,31-15-19-33(52-7)20-16-31)32-17-21-34(53-8)22-18-32/h9-11,13-22,25,28-29,36,38-40H,12,24,26-27H2,1-8H3,(H,45,49)(H,46,50,51)/t36-,38+,39-,40+,59?/m1/s1

2'-OEt-S-S-tBu C(Bz) amidite

Description: 2'-OEt-S-S-tBu C(Bz) amidite is a reagent used in oligonucleotide synthesis, containing a disulfide linkage with tert-butyl (tBu) termination and cytosine protected with benzoyl (Bz) group at the 2' position of ribose. This modification allows for the introduction of reversible crosslinking or enhanced stability properties to the resulting oligonucleotides.

CAT: BRP-00967

CAS: 176747-35-6

Molecular Formula: C52H64N5O9PS2

Molecular Weight: 998.22

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: GGJPSSSMERVJTA-YOVDOAOFSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OCCSSC(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-(tert-butyldisulfaneyl)ethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H64N5O9PS2/c1-36(2)57(37(3)4)67(64-32-16-30-53)66-46-44(35-63-52(39-19-14-11-15-20-39,40-21-25-42(60-8)26-22-40)41-23-27-43(61-9)28-24-41)65-49(47(46)62-33-34-68-69-51(5,6)7)56-31-29-45(55-50(56)59)54-48(58)38-17-12-10-13-18-38/h10-15,17-29,31,36-37,44,46-47,49H,16,32-35H2,1-9H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[2-[(1,1-dimethylethyl)dithio]ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Thio(Bz) C6 amidite

Description: Thio(Bz) C6 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with a benzoyl (Bz) protecting group and a 6-carbon linker. This reagent allows for the introduction of a thiol-modified linker with a 6-carbon chain length into oligonucleotide sequences during synthesis. Thiol modifications can be employed for various applications such as covalent conjugation, labeling, or surface immobilization in bioassays.

CAT: BRP-00968

CAS: 176640-52-1

Molecular Formula: C22H35N2O3PS

Molecular Weight: 438.57

Purity: >95%

Appearance: Light-yellow oily matter

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: UDUVXNZCIKTQTP-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCSC(=O)C=1C=CC=CC1)N(C(C)C)C(C)C

IUPAC Name: S-(6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl) benzothioate

InChI: InChI=1S/C22H35N2O3PS/c1-19(2)24(20(3)4)28(27-17-12-15-23)26-16-10-5-6-11-18-29-22(25)21-13-8-7-9-14-21/h7-9,13-14,19-20H,5-6,10-12,16-18H2,1-4H3

Synonyms: Benzenecarbothioic acid, S-[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ester; S-[6-[[[Bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] benzenecarbothioate

Thio(Ac) C6 amidite

Description: Thio(Ac) C6 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with an acetyl (Ac) protecting group and a 6-carbon linker. This reagent enables the introduction of a thiol-modified linker with a 6-carbon chain length into oligonucleotide sequences during synthesis. Thiol modifications can be utilized for various applications such as covalent conjugation, labeling, or surface immobilization in bioassays.

CAT: BRP-00969

CAS: 176640-51-0

Molecular Formula: C17H33N2O3PS

Molecular Weight: 376.50

Purity: >95%

Appearance: Light-yellow oily matter

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: YYZTVJUOQPJPLL-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCSC(=O)C)N(C(C)C)C(C)C

IUPAC Name: S-(6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl) ethanethioate

InChI: InChI=1S/C17H33N2O3PS/c1-15(2)19(16(3)4)23(22-13-10-11-18)21-12-8-6-7-9-14-24-17(5)20/h15-16H,6-10,12-14H2,1-5H3

Synonyms: Ethanethioic acid, S-[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ester; S-[6-[[[Bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ethanethioate

Thio(Ac)-PEG3 amidite

Description: Thio(Ac)-PEG3 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with an acetyl (Ac) protecting group and a polyethylene glycol (PEG) linker of three ethylene glycol units. This reagent allows for the introduction of a thiol-modified linker with a PEG3 spacer into oligonucleotide sequences during synthesis. Thiol modifications with PEG linkers are often employed for various applications such as covalent conjugation, labeling, or improving solubility and flexibility of oligonucleotides.

CAT: BRP-00970

CAS: 153870-21-4

Molecular Formula: C17H33N2O5PS

Molecular Weight: 408.50

Purity: >95%

Appearance: Light-yellow oily matter

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: FMIVUFGXNQLSTH-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCSC(=O)C

IUPAC Name: S-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethyl] ethanethioate

InChI: InChI=1S/C17H33N2O5PS/c1-15(2)19(16(3)4)25(23-8-6-7-18)24-12-11-21-9-10-22-13-14-26-17(5)20/h15-16H,6,8-14H2,1-5H3

Synonyms: Ethanethioic acid, S-[10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-3,6,9-trioxa-11-aza-10-phosphatridec-1-yl] ester; Ethanethioic acid, S-[10-[bis(1-methylethyl)amino]-13-cyano-3,6,9,11-tetraoxa-10-phosphatridec-1-yl] ester; S-[10-(2-Cyanoethoxy)-12-methyl-11-(1-methylethyl)-3,6,9-trioxa-11-aza-10-phosphatridec-1-yl] ethanethioate; S-(2-(2-(2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethoxy)ethyl) ethanethioate

UNA 2'-OBz C(Bz) amidite

Description: UNA 2'-OBz C(Bz) amidite is a reagent used in oligonucleotide synthesis, containing an Unlocked Nucleic Acid (UNA) backbone modification. In this designation, 2'-OBz indicates a benzoyl (Bz) protecting group at the 2' position of ribose, and C(Bz) indicates cytosine (C) protected with a benzoyl group. This reagent is utilized for synthesizing oligonucleotides with UNA backbone modifications, which increase the flexibility of the oligonucleotide backbone. UNA modifications can confer specific properties to oligonucleotides, such as altering hybridization behavior or enhancing nuclease resistance, suitable for various biotechnological applications.

CAT: BRP-00971

Molecular Formula: C53H58N5O10P

Molecular Weight: 956.05

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: MINLZVSGJNTMMR-OBHWIOKQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R)-2-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(((2R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propan-2-yl)oxy)ethyl benzoate

InChI: InChI=1S/C53H58N5O10P/c1-38(2)58(39(3)4)69(66-34-16-32-54)67-36-47(35-65-53(42-21-14-9-15-22-42,43-23-27-45(62-5)28-24-43)44-25-29-46(63-6)30-26-44)68-49(37-64-51(60)41-19-12-8-13-20-41)57-33-31-48(56-52(57)61)55-50(59)40-17-10-7-11-18-40/h7-15,17-31,33,38-39,47,49H,16,34-37H2,1-6H3,(H,55,56,59,61)/t47-,49-,69?/m1/s1

Synonyms: N6-Bz-C-UNA-Phosphoramidite; 2'-OBz-N6-Bz-C-UNA-Phosphoramidite; 2'-OBz-C(Bz)-UNA-Phosphoramidite; 2'-OBz-C(Bz)-UNA-3'-CE-Phosphoramidite

2'-MOE PseudoUridine amidite

Description: 2'-MOE PseudoUridine amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates PseudoUridine, a modified nucleoside resembling uridine. This allows for the synthesis of oligonucleotides containing PseudoUridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.

CAT: BRP-00972

CAS: 1417162-48-1

Molecular Formula: C42H53N4O10P

Molecular Weight: 804.88

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: QGENAASPFJKDDU-APSGJOCZSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(C2=CNC(=O)NC2=O)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H53N4O10P/c1-28(2)46(29(3)4)57(54-23-11-22-43)56-38-36(55-37(39(38)52-25-24-49-5)35-26-44-41(48)45-40(35)47)27-53-42(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-21,26,28-29,36-39H,11,23-25,27H2,1-7H3,(H2,44,45,47,48)/t36-,37+,38-,39+,57?/m1/s1

Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-(2-methoxyethyl)-β-D-ribofuranosyl]-; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-(2-methoxyethyl)-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione

2'-MOE N1-Methyl PseudoUridine amidite

Description: 2'-MOE N1-Methyl PseudoUridine amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates N1-Methyl PseudoUridine, a modified nucleoside resembling uridine with a methyl group attached to the nitrogen at position 1. It enables the synthesis of oligonucleotides containing N1-Methyl PseudoUridine modifications, offering specific properties or functionalities to the resulting oligonucleotides, suitable for various biotechnological applications.

CAT: BRP-00973

Molecular Formula: C43H55N4O10P

Molecular Weight: 818.91

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: FWVPZDATJBTJIH-SAAFSQBVSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H55N4O10P/c1-29(2)47(30(3)4)58(55-24-12-23-44)57-39-37(56-38(40(39)53-26-25-50-6)36-27-46(5)42(49)45-41(36)48)28-54-43(31-13-10-9-11-14-31,32-15-19-34(51-7)20-16-32)33-17-21-35(52-8)22-18-33/h9-11,13-22,27,29-30,37-40H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38+,39-,40+,58?/m1/s1

2'-OMe 5-Ethynyl-U amidite

Description: 2'-OMe 5-Ethynyl-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates 5-Ethynyl-Uridine (5-Ethynyl-U), a modified uridine nucleoside with an ethynyl group attached at the 5-position of the uracil base. It allows for the synthesis of oligonucleotides containing 5-Ethynyl-Uridine modifications, which can be useful for various applications such as click chemistry reactions for further functionalization or conjugation.

CAT: BRP-00974

CAS: 2201814-30-2

Molecular Formula: C42H49N4O9P

Molecular Weight: 784.85

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: FTWDORGUPXUAIL-WDABSCDASA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C#C)C(=O)NC2=O)C1OC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-ethynyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H49N4O9P/c1-9-30-26-45(41(48)44-39(30)47)40-38(51-8)37(55-56(53-25-13-24-43)46(28(2)3)29(4)5)36(54-40)27-52-42(31-14-11-10-12-15-31,32-16-20-34(49-6)21-17-32)33-18-22-35(50-7)23-19-33/h1,10-12,14-23,26,28-29,36-38,40H,13,25,27H2,2-8H3,(H,44,47,48)/t36-,37-,38-,40-,56?/m1/s1

2'-MOE 2-Thio-U amidite

Description: 2'-MOE 2-Thio-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates 2-Thio-Uridine (2-Thio-U), a modified uridine nucleoside with a sulfur atom (S) at the 2-position of the uracil base. It facilitates the synthesis of oligonucleotides containing 2-Thio-Uridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.

CAT: BRP-00975

CAS: 647839-25-6

Molecular Formula: C42H53N4O9PS

Molecular Weight: 820.95

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: PRCKCMMLZPXTNK-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=CC(=O)NC2=S)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H53N4O9PS/c1-29(2)46(30(3)4)56(53-25-11-23-43)55-38-36(54-40(39(38)51-27-26-48-5)45-24-22-37(47)44-41(45)57)28-52-42(31-12-9-8-10-13-31,32-14-18-34(49-6)19-15-32)33-16-20-35(50-7)21-17-33/h8-10,12-22,24,29-30,36,38-40H,11,25-28H2,1-7H3,(H,44,47,57)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-OMe 2-Thio-U amidite

Description: 2'-OMe 2-Thio-U amidite is a reagent employed in oligonucleotide synthesis. This reagent features a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates 2-Thio-Uridine (2-Thio-U), which is a modified uridine nucleoside with a sulfur atom (S) at the 2-position of the uracil base. It enables the synthesis of oligonucleotides containing 2-Thio-Uridine modifications. These modifications can confer specific properties or functionalities to the resulting oligonucleotides, suitable for various applications in biotechnology and molecular biology.

CAT: BRP-00976

CAS: 302918-84-9

Molecular Formula: C40H49N4O8PS

Molecular Weight: 776.89

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: DWDMFECIJNQDJC-GFIGKZKCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=S)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H49N4O8PS/c1-27(2)44(28(3)4)53(50-25-11-23-41)52-36-34(51-38(37(36)48-7)43-24-22-35(45)42-39(43)54)26-49-40(29-12-9-8-10-13-29,30-14-18-32(46-5)19-15-30)31-16-20-33(47-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,54)/t34-,36-,37-,38-,53?/m1/s1

Synonyms: 2'-O-Me-2-thio-U-3'-phosphoramidite; 2'-O-Me-s2U-3'-[2-cyanoethyl-N,N-diisopropylphosphoramidite]; 5'-O-DMTr-2'-O-methyl-2-thiouridine-3'-CED-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-2-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Me-2-thiouridine-3'-CE-Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyl-2-thiouridine-3'-cyanoethyl Phosphoramidite

2'-OTBS 5-CMOM-U amidite

Description: 2'-OTBS 5-CMOM-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-tert-butyldimethylsilyl (OTBS) and incorporates 5-CMOM-Uridine (5-CMOM-U). It allows for the synthesis of oligonucleotides containing 5-CMOM-Uridine modifications, which can be useful for various applications in oligonucleotide chemistry and nucleic acid research.

CAT: BRP-00977

CAS: 321991-69-9

Molecular Formula: C48H65N4O11PSi

Molecular Weight: 933.13

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: LBQONPUJFDFCPG-ZHVPLOFZSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)CC(=O)OC)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: methyl 2-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]acetate

InChI: InChI=1S/C48H65N4O11PSi/c1-32(2)52(33(3)4)64(60-28-16-27-49)62-42-40(61-45(43(42)63-65(11,12)47(5,6)7)51-30-34(29-41(53)58-10)44(54)50-46(51)55)31-59-48(35-17-14-13-15-18-35,36-19-23-38(56-8)24-20-36)37-21-25-39(57-9)26-22-37/h13-15,17-26,30,32-33,40,42-43,45H,16,28-29,31H2,1-12H3,(H,50,54,55)/t40-,42-,43-,45-,64?/m1/s1

Synonyms: methyl 2-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate; 5-Pyrimidineacetic acid, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-1,2,3,4-tetrahydro-2,4-dioxo-, methyl ester; Methyl 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidineacetate

2'-OTBS 5,6-dihydro-U amidite

Description: 2'-OTBS 5,6-dihydro-U amidite is a compound used in oligonucleotide synthesis. It features protective groups (DMTr and TBDMS) for the 5'- and 2'-hydroxyl groups, respectively, and a 5,6-dihydrouridine modification. Additionally, it contains a 3'-cyanoethyl (CE) phosphoramidite group for incorporation into oligonucleotide chains during synthesis.

CAT: BRP-00978

CAS: 126684-14-8

Molecular Formula: C45H63N4O9PSi

Molecular Weight: 863.08

Purity: >98%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: DJGPHGMBOQJJIE-ZMHKPELYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2CCC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxo-1,3-diazinan-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H63N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-40-38(56-42(48-28-26-39(50)47-43(48)51)41(40)58-60(10,11)44(5,6)7)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-25,31-32,38,40-42H,15,26,28-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5,6-dihydro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5,6-dihydro-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMTr-2'-O-TBDMS-5,6-dihydrouridine-3'-CE-Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-5,6-dihydrouridine-3'-cyanoethyl Phosphoramidite; 5,6-dihydrouridine-2'-TBDMS-5'-DMT 3'-CED phosphoramidite

2'-OTBS 5-PivOM-U amidite

Description: 2'-OTBS 5-PivOM-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-tert-butyldimethylsilyl (OTBS) and incorporates 5-PivOM-Uridine (5-PivOM-U), a modified uridine nucleoside with a 5'-O-(pivaloyloxymethyl) (PivOM) protecting group attached at the 5-position of the uracil base. It enables the synthesis of oligonucleotides containing 5-PivOM-Uridine modifications, which can be useful for various applications in oligonucleotide chemistry and nucleic acid research.

CAT: BRP-00979

CAS: 2087953-37-3

Molecular Formula: C51H71N4O11PSi

Molecular Weight: 975.21

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: DJJDOAIVIHEKMZ-GXXQHJQMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=O)NC2=O)COC(=O)C(C)(C)C)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl pivalate

InChI: InChI=1S/C51H71N4O11PSi/c1-34(2)55(35(3)4)67(63-30-18-29-52)65-43-42(33-62-51(37-19-16-15-17-20-37,38-21-25-40(59-11)26-22-38)39-23-27-41(60-12)28-24-39)64-46(44(43)66-68(13,14)50(8,9)10)54-31-36(45(56)53-48(54)58)32-61-47(57)49(5,6)7/h15-17,19-28,31,34-35,42-44,46H,18,30,32-33H2,1-14H3,(H,53,56,58)/t42-,43-,44-,46-,67?/m1/s1

2'-OTBS 5-(3''-amino(TFA)-propynyl)-U amidite

Description: 2'-OTBS 5-(3''-amino(TFA)-propynyl)-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-tert-butyldimethylsilyl (OTBS) and incorporates 5-(3''-amino(TFA)-propynyl)-Uridine, which consists of a propynyl linker with an amino group modified with trifluoroacetic acid (TFA) protection, attached at the 5-position of the uracil base. It allows for the synthesis of oligonucleotides containing this specific modification, which can be useful for various applications such as conjugation, labeling, or functionalization of oligonucleotides.

CAT: BRP-00980

CAS: 1269413-23-1

Molecular Formula: C50H63F3N5O10PSi

Molecular Weight: 1010.13

Purity: >95%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: WJZHTBADFQJCHH-UETLZWTDSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C#CCNC(=O)C(F)(F)F)C(=O)NC2=O)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-5-(3-(2,2,2-trifluoroacetamido)prop-1-yn-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H63F3N5O10PSi/c1-33(2)58(34(3)4)69(65-30-16-28-54)67-42-41(32-64-49(36-18-13-12-14-19-36,37-20-24-39(62-8)25-21-37)38-22-26-40(63-9)27-23-38)66-45(43(42)68-70(10,11)48(5,6)7)57-31-35(44(59)56-47(57)61)17-15-29-55-46(60)50(51,52)53/h12-14,18-27,31,33-34,41-43,45H,16,29-30,32H2,1-11H3,(H,55,60)(H,56,59,61)/t41-,42-,43-,45-,69?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

2'-OMe N3-Bz-U amidite

Description: 2'-OMe N3-Bz-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates N3-Benzoyl-Uridine (N3-Bz-U), a modified uridine nucleoside with a benzoyl group (Bz) attached at the N3 position of the uracil base. It enables the synthesis of oligonucleotides containing N3-Benzoyl-Uridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.

CAT: BRP-00981

CAS: 178422-03-2

Molecular Formula: C47H53N4O10P

Molecular Weight: 864.93

Purity: >98%

Appearance: Off-white solid

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: RLZUETJITSYKAT-VKBHKTMGSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)N(C2=O)C(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-5-(3-benzoyl-2,4-dioxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C47H53N4O10P/c1-32(2)51(33(3)4)62(59-30-14-28-48)61-42-40(60-45(43(42)57-7)49-29-27-41(52)50(46(49)54)44(53)34-15-10-8-11-16-34)31-58-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3/t40-,42-,43-,45-,62?/m1/s1

Synonyms: N3-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine-3'-cyanoethyl phosphoramidite; (2R,3R,4R,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Uridine, 3-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl [bis(1-methylethyl)amino]phosphoramidite]; DMT-2'-O-Me-U(Bz)-CE-Phosphoramidite

5'-O-DMTr-2'-OMe-C(Ac)-3'-Methoxy-phosphoramidite

Description: 5'-O-DMTr-2'-OMe-C(Ac)-3'-Methoxy-phosphoramidite is a reagent used in oligonucleotide synthesis. It features a dimethoxytrityl (DMTr) protecting group at the 5' hydroxyl, a cytosine nucleoside modified with 2'-O-methyl (OMe) and acetyl (Ac) protection, and a methoxy group at the 3' position of the phosphoramidite. This reagent enables controlled synthesis of oligonucleotides with specific modifications, crucial for various applications in molecular biology and nucleic acid research.

CAT: BRP-00982

Molecular Formula: C40H51N4O9P

Molecular Weight: 762.84

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: NHLKBIREBJIEBF-XKZJCBTISA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C40H51N4O9P/c1-26(2)44(27(3)4)54(50-9)53-36-34(52-38(37(36)49-8)43-24-23-35(41-28(5)45)42-39(43)46)25-51-40(29-13-11-10-12-14-29,30-15-19-32(47-6)20-16-30)31-17-21-33(48-7)22-18-31/h10-24,26-27,34,36-38H,25H2,1-9H3,(H,41,42,45,46)/t34-,36-,37-,38-,54?/m1/s1

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-Methoxy-phosphoramidite; 2'-OMe C(Ac) OMe-amidite

5'-O-DMTr-2'-O-MOE-5-Me-U-3'-Methoxy-phosphoramidite

Description: 5'-O-DMTr-2'-O-MOE-5-Me-U-3'-Methoxy-phosphoramidite is a reagent used in oligonucleotide synthesis. It contains a dimethoxytrityl (DMTr) protecting group at the 5' hydroxyl, a 2'-O-methoxyethyl (MOE) modification, a 5-Methyl-Uridine (5-Me-U), and a methoxy group at the 3' position of the phosphoramidite. This reagent facilitates the synthesis of oligonucleotides with specific modifications, which can influence stability, hybridization properties, or enzymatic resistance of the resulting oligonucleotides.

CAT: BRP-00983

CAS: 674798-37-9

Molecular Formula: C41H54N3O10P

Molecular Weight: 779.87

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: MGCBWJZQSWUFBV-VNZAIEIISA-N

CanonicalSMILES: O=C1NC(=O)N(C=C1C)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2OCCOC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C41H54N3O10P/c1-27(2)44(28(3)4)55(50-9)54-36-35(53-39(37(36)51-24-23-47-6)43-25-29(5)38(45)42-40(43)46)26-52-41(30-13-11-10-12-14-30,31-15-19-33(48-7)20-16-31)32-17-21-34(49-8)22-18-32/h10-22,25,27-28,35-37,39H,23-24,26H2,1-9H3,(H,42,45,46)/t35-,36-,37-,39-,55?/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-uridine-3'-Methoxy-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 2'-MOE-5-Me-U OMe-amidite

5'-O-DMTr-2'-O-MOE-G(iBu)-3'-Methoxy-phosphoramidite

Description: 5'-O-DMTr-2'-O-MOE-G(iBu)-3'-Methoxy-phosphoramidite is a reagent used in oligonucleotide synthesis. It contains a dimethoxytrityl (DMTr) protecting group at the 5' hydroxyl, a 2'-O-methoxyethyl (MOE) modification, a guanosine nucleoside with an isobutyl (iBu) protecting group, and a methoxy group at the 3' position of the phosphoramidite. This reagent enables the synthesis of oligonucleotides with specific modifications, which can affect stability, hybridization properties, or enzymatic resistance of the resulting oligonucleotides.

CAT: BRP-00984

Molecular Formula: C45H59N6O10P

Molecular Weight: 874.97

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at -20 °C

InChIKey: RLSHXUDUUUJCEZ-MLLDKZSOSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C45H59N6O10P/c1-28(2)41(52)48-44-47-40-37(42(53)49-44)46-27-50(40)43-39(58-25-24-54-7)38(61-62(57-10)51(29(3)4)30(5)6)36(60-43)26-59-45(31-14-12-11-13-15-31,32-16-20-34(55-8)21-17-32)33-18-22-35(56-9)23-19-33/h11-23,27-30,36,38-39,43H,24-26H2,1-10H3,(H2,47,48,49,52,53)/t36-,38-,39-,43-,62?/m1/s1

Synonyms: N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine-3'-Methoxy-phosphoramidite; 2'-MOE G(iBu) OMe-amidite

2'-O-NMA PseudoUridine amidite

2'-O-NMA N1-Methyl PseudoUridine amidite

2'-OEt-S-S-tBu C(Bz) amidite

Thio(Bz) C6 amidite

Thio(Ac) C6 amidite

Thio(Ac)-PEG3 amidite

UNA 2'-OBz C(Bz) amidite

2'-MOE PseudoUridine amidite

2'-MOE N1-Methyl PseudoUridine amidite

2'-OMe 5-Ethynyl-U amidite

2'-MOE 2-Thio-U amidite

2'-OMe 2-Thio-U amidite

2'-OTBS 5-CMOM-U amidite

2'-OTBS 5,6-dihydro-U amidite

2'-OTBS 5-PivOM-U amidite

2'-OTBS 5-(3''-amino(TFA)-propynyl)-U amidite

2'-OMe N3-Bz-U amidite

5'-O-DMTr-2'-OMe-C(Ac)-3'-Methoxy-phosphoramidite

5'-O-DMTr-2'-O-MOE-5-Me-U-3'-Methoxy-phosphoramidite

5'-O-DMTr-2'-O-MOE-G(iBu)-3'-Methoxy-phosphoramidite

Our Products

Liposome Products

MicroRNA Products

mRNA Products

siRNA Products

RNA Synthesis Reagents

Cap Analogs

CPGs for Oligo Synthesis

Nucleosides

Nucleotides

Phosphoramidites