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Phosphoramidites

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2'-Modified Phosphoramidites
(594/594) 2'-Phosphoramidites
(27/27) 3'-Modified Phosphoramidites
(246/246) 5'-Modified Phosphoramidites
(79/79) Arabino Phosphoramidites
(24/24) Base Protected Phosphoramidites (469/469) Dye Phosphoramidites
(72/72) Label Phosphoramidites
(86/86) Linker Phosphoramidites
(113/113) Other Phosphoramidites
(94/94) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(25/25) Spacer Phosphoramidites
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1-DMTr-3-(S)-butanediyl amidite (BRP-00957)

1-DMTr-3-(S)-butanediyl amidite

Description: 1-DMTr-3-(S)-butanediyl amidite is a reagent used in solid-phase oligonucleotide synthesis. This reagent allows for the introduction of a chiral butanediyl spacer into oligonucleotides during synthesis. Chiral spacers can introduce specific properties or functionalities to oligonucleotides, useful for various applications in biotechnology and therapeutics.
CAT: BRP-00957
CAS: 161106-24-7
Molecular Formula: C34H45N2O5P
Molecular Weight: 592.72
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: QTYXEIMXWNEEOP-DHZXTJRXSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: N#CCCOP(OC(C)CCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C
IUPAC Name: 3-[[(2S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]butan-2-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C34H45N2O5P/c1-26(2)36(27(3)4)42(40-24-11-23-35)41-28(5)22-25-39-34(29-12-9-8-10-13-29,30-14-18-32(37-6)19-15-30)31-16-20-33(38-7)21-17-31/h8-10,12-21,26-28H,11,22,24-25H2,1-7H3/t28-,42?/m0/s1
Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, (1S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-1-methylpropyl 2-cyanoethyl ester; Phosphoramidous acid, bis(1-methylethyl)-, 3-[bis(4-methoxyphenyl)phenylmethoxy]-1-methylpropyl 2-cyanoethyl ester, (1S)-; (S)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
Propargyl C4 amidite (BRP-00958)

Propargyl C4 amidite

Description: Propargyl C4 amidite is a reagent used in oligonucleotide synthesis. This reagent allows for the introduction of a propargyl modification of the nucleobase during oligonucleotide synthesis. Propargyl modifications are useful for various applications such as click chemistry reactions for further functionalization or conjugation.
CAT: BRP-00958
CAS: 1173382-08-5
Molecular Formula: C16H29N2O3P
Molecular Weight: 328.39
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: LQEYCRIHZDOGRQ-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: N#CCCOP(OCCCCOCC#C)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl (4-(prop-2-yn-1-yloxy)butyl) diisopropylphosphoramidite
InChI: InChI=1S/C16H29N2O3P/c1-6-11-19-12-7-8-13-20-22(21-14-9-10-17)18(15(2)3)16(4)5/h1,15-16H,7-9,11-14H2,2-5H3
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 4-(2-propyn-1-yloxy)butyl ester; 2-Cyanoethyl 4-(2-propyn-1-yloxy)butyl N,N-bis(1-methylethyl)phosphoramidite
2'-OTBS Pyridinone amidite (BRP-00959)

2'-OTBS Pyridinone amidite

Description: 2'-OTBS Pyridinone amidite is a reagent used in oligonucleotide synthesis, featuring a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose and incorporating a pyridinone moiety. This amidite enables the controlled synthesis of oligonucleotides with pyridinone modifications, offering unique properties or functionalities for applications in biotechnology and therapeutics.
CAT: BRP-00959
CAS: 179915-57-2
Molecular Formula: C46H62N3O8PSi
Molecular Weight: 844.08
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: FMVRDFSSWDAZFJ-VDXGOTTOSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC=CC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2-oxopyridin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C46H62N3O8PSi/c1-33(2)49(34(3)4)58(54-31-17-29-47)56-42-40(55-44(48-30-16-15-20-41(48)50)43(42)57-59(10,11)45(5,6)7)32-53-46(35-18-13-12-14-19-35,36-21-25-38(51-8)26-22-36)37-23-27-39(52-9)28-24-37/h12-16,18-28,30,33-34,40,42-44H,17,31-32H2,1-11H3/t40-,42-,43-,44-,58?/m1/s1
Synonyms: Pyridin-2-one-CE Phosphoramidite; 5'-Dimethoxytrityl-pyridin-2-one-riboside, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Pyridin-2-one riboside CEP; 2(1H)-Pyridinone, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-; 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-2(1H)-pyridinone; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxopyridin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Pyridine-2-One CED phosphoramidite
Tocopherol amidite (BRP-00960)

Tocopherol amidite

Description: Tocopherol amidite is a reagent utilized in oligonucleotide synthesis. It contains a tocopherol moiety, which is a form of vitamin E, attached to an amidite group suitable for solid-phase synthesis. This reagent allows for the conjugation of tocopherol to oligonucleotides during synthesis. Tocopherol modifications can provide various properties such as increased stability, cellular uptake, or antioxidant activity to the resulting oligonucleotides, making them potentially useful for applications in drug delivery or other biomedical fields.
CAT: BRP-00960
CAS: 142386-74-1
Molecular Formula: C38H67N2O3P
Molecular Weight: 630.94
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: USUSEQXJHLFSON-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OP(N(C(C)C)C(C)C)OCCC#N)C
IUPAC Name: 3-[[di(propan-2-yl)amino]-[[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl]oxy]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C38H67N2O3P/c1-27(2)17-13-18-30(7)19-14-20-31(8)21-15-23-38(12)24-22-35-34(11)36(32(9)33(10)37(35)42-38)43-44(41-26-16-25-39)40(28(3)4)29(5)6/h27-31H,13-24,26H2,1-12H3
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester; 2-Cyanoethyl 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester; 2-cyanoethyl (2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-yl) diisopropylphosphoramidite
C8 amidite (BRP-00961)

C8 amidite

Description: C8 amidite is a linker used in oligonucleotide synthesis. This linker provides a connection between the oligonucleotide and other molecules or surfaces during synthesis or conjugation processes. The ''C8'' designation indicates that it consists of a linker with an 8-carbon chain length. This linker facilitates the attachment of oligonucleotides to various molecules or surfaces, enabling specific applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in bioassays.
CAT: BRP-00961
CAS: 194015-05-9
Molecular Formula: C17H35N2O2P
Molecular Weight: 330.45
Purity: >98%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: SYIZTDJMSOSVGQ-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: CCCCCCCCOP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: 3-[[di(propan-2-yl)amino]-octoxyphosphanyl]oxypropanenitrile
InChI: InChI=1S/C17H35N2O2P/c1-6-7-8-9-10-11-14-20-22(21-15-12-13-18)19(16(2)3)17(4)5/h16-17H,6-12,14-15H2,1-5H3
Synonyms: 2-Cyanoethyl octyl diisopropylphosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl octyl ester; O-β-Cyanoethyl-O-octyl-N,N-diisopropyl phosphoramidite
C11 amidite (BRP-00962)

C11 amidite

Description: C11 amidite is a linker used in oligonucleotide synthesis, consisting of an 11-carbon chain length. This linker facilitates the connection between the oligonucleotide and other molecules or surfaces during synthesis or conjugation processes. It provides flexibility and space between the oligonucleotide and the attached moiety, enabling various applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in bioassays.
CAT: BRP-00962
CAS: 125676-85-9
Molecular Formula: C20H41N2O2P
Molecular Weight: 372.53
Purity: >98%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: IJPKCIKPYVOSEV-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: N#CCCOP(OCCCCCCCCCCC)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl undecyl diisopropylphosphoramidite
InChI: InChI=1S/C20H41N2O2P/c1-6-7-8-9-10-11-12-13-14-17-23-25(24-18-15-16-21)22(19(2)3)20(4)5/h19-20H,6-15,17-18H2,1-5H3
Synonyms: 2-Cyanoethyl undecyl diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl undecyl ester; 2-Cyanoethyl undecyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl undecyl ester
C14 amidite (BRP-00963)

C14 amidite

Description: C14 amidite is a linker utilized in oligonucleotide synthesis, featuring a 14-carbon chain length. This linker serves to connect the oligonucleotide to other molecules or surfaces during synthesis or conjugation processes. The ''C14'' designation indicates the length of the carbon chain in the linker. It provides flexibility and space between the oligonucleotide and the attached moiety, facilitating specific applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in various bioassays.
CAT: BRP-00963
CAS: 198987-41-6
Molecular Formula: C23H47N2O2P
Molecular Weight: 414.62
Purity: >98%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: BGMXNCIZEALUBC-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: CCCCCCCCCCCCCCOP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: 3-[[di(propan-2-yl)amino]-tetradecoxyphosphanyl]oxypropanenitrile
InChI: InChI=1S/C23H47N2O2P/c1-6-7-8-9-10-11-12-13-14-15-16-17-20-26-28(27-21-18-19-24)25(22(2)3)23(4)5/h22-23H,6-18,20-21H2,1-5H3
Synonyms: 2-Cyanoethyl tetradecyl diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl tetradecyl ester; 2-Cyanoethyl tetradecyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl tetradecyl ester
11-Br-C11 amidite (BRP-00964)

11-Br-C11 amidite

Description: 11-Br-C11 amidite is a reagent used in oligonucleotide synthesis, featuring an 11-carbon chain length with a bromine (Br) atom. This linker allows for the attachment of oligonucleotides to other molecules or surfaces during synthesis or conjugation processes. The bromine atom provides a reactive site for further functionalization or coupling reactions. It provides flexibility and space between the oligonucleotide and the attached moiety, enabling specific applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in various bioassays.
CAT: BRP-00964
CAS: 804567-08-6
Molecular Formula: C20H40BrN2O2P
Molecular Weight: 451.43
Purity: >98%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: MZMSOHBMQFZJNM-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: N#CCCOP(OCCCCCCCCCCCBr)N(C(C)C)C(C)C
IUPAC Name: 11-bromoundecyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C20H40BrN2O2P/c1-19(2)23(20(3)4)26(25-18-14-16-22)24-17-13-11-9-7-5-6-8-10-12-15-21/h19-20H,5-15,17-18H2,1-4H3
Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 11-bromoundecyl 2-cyanoethyl ester
2'-O-NMA PseudoUridine amidite (BRP-00965)

2'-O-NMA PseudoUridine amidite

Description: 2'-O-NMA PseudoUridine amidite is a reagent used in oligonucleotide synthesis, featuring a modification at the 2' position of ribose with N-methylaminomethylene (NMA) and incorporating a pseudo-uridine moiety. This reagent enables the synthesis of oligonucleotides containing pseudo-uridine modifications, which can confer specific properties or functionalities to the resulting oligonucleotides. PseudoUridine modifications are valuable for applications in biotechnology and therapeutics due to their potential to enhance stability, specificity, or other desired characteristics.
CAT: BRP-00965
Molecular Formula: C42H52N5O10P
Molecular Weight: 817.88
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: NHSKCVXWHUBLRO-AZUJSHLHSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C42H52N5O10P/c1-27(2)47(28(3)4)58(55-23-11-22-43)57-38-35(56-37(39(38)53-26-36(48)44-5)34-24-45-41(50)46-40(34)49)25-54-42(29-12-9-8-10-13-29,30-14-18-32(51-6)19-15-30)31-16-20-33(52-7)21-17-31/h8-10,12-21,24,27-28,35,37-39H,11,23,25-26H2,1-7H3,(H,44,48)(H2,45,46,49,50)/t35-,37+,38-,39+,58?/m1/s1
2'-O-NMA N1-Methyl PseudoUridine amidite (BRP-00966)

2'-O-NMA N1-Methyl PseudoUridine amidite

Description: 2'-O-NMA N1-Methyl PseudoUridine amidite is a reagent employed in oligonucleotide synthesis. It involves a modification at the 2' position of ribose with N-methylaminomethylene (NMA) and incorporates N1-Methyl PseudoUridine, a modified nucleoside resembling uridine with a methyl group attached to the nitrogen at position 1. This reagent enables the synthesis of oligonucleotides with N1-Methyl PseudoUridine modifications, offering specific properties or functionalities to the resulting oligonucleotides. These modifications can be advantageous for various biotechnological and therapeutic applications, providing enhanced stability or other desired characteristics.
CAT: BRP-00966
Molecular Formula: C43H54N5O10P
Molecular Weight: 831.90
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: PRKXXSDXURDTSF-ZIVCPKBRSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H54N5O10P/c1-28(2)48(29(3)4)59(56-24-12-23-44)58-39-36(57-38(40(39)54-27-37(49)45-5)35-25-47(6)42(51)46-41(35)50)26-55-43(30-13-10-9-11-14-30,31-15-19-33(52-7)20-16-31)32-17-21-34(53-8)22-18-32/h9-11,13-22,25,28-29,36,38-40H,12,24,26-27H2,1-8H3,(H,45,49)(H,46,50,51)/t36-,38+,39-,40+,59?/m1/s1
2'-OEt-S-S-tBu C(Bz) amidite (BRP-00967)

2'-OEt-S-S-tBu C(Bz) amidite

Description: 2'-OEt-S-S-tBu C(Bz) amidite is a reagent used in oligonucleotide synthesis, containing a disulfide linkage with tert-butyl (tBu) termination and cytosine protected with benzoyl (Bz) group at the 2' position of ribose. This modification allows for the introduction of reversible crosslinking or enhanced stability properties to the resulting oligonucleotides.
CAT: BRP-00967
CAS: 176747-35-6
Molecular Formula: C52H64N5O9PS2
Molecular Weight: 998.22
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: GGJPSSSMERVJTA-YOVDOAOFSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OCCSSC(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-(tert-butyldisulfaneyl)ethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C52H64N5O9PS2/c1-36(2)57(37(3)4)67(64-32-16-30-53)66-46-44(35-63-52(39-19-14-11-15-20-39,40-21-25-42(60-8)26-22-40)41-23-27-43(61-9)28-24-41)65-49(47(46)62-33-34-68-69-51(5,6)7)56-31-29-45(55-50(56)59)54-48(58)38-17-12-10-13-18-38/h10-15,17-29,31,36-37,44,46-47,49H,16,32-35H2,1-9H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m1/s1
Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[2-[(1,1-dimethylethyl)dithio]ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
Thio(Bz) C6 amidite (BRP-00968)

Thio(Bz) C6 amidite

Description: Thio(Bz) C6 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with a benzoyl (Bz) protecting group and a 6-carbon linker. This reagent allows for the introduction of a thiol-modified linker with a 6-carbon chain length into oligonucleotide sequences during synthesis. Thiol modifications can be employed for various applications such as covalent conjugation, labeling, or surface immobilization in bioassays.
CAT: BRP-00968
CAS: 176640-52-1
Molecular Formula: C22H35N2O3PS
Molecular Weight: 438.57
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: UDUVXNZCIKTQTP-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: N#CCCOP(OCCCCCCSC(=O)C=1C=CC=CC1)N(C(C)C)C(C)C
IUPAC Name: S-(6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl) benzothioate
InChI: InChI=1S/C22H35N2O3PS/c1-19(2)24(20(3)4)28(27-17-12-15-23)26-16-10-5-6-11-18-29-22(25)21-13-8-7-9-14-21/h7-9,13-14,19-20H,5-6,10-12,16-18H2,1-4H3
Synonyms: Benzenecarbothioic acid, S-[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ester; S-[6-[[[Bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] benzenecarbothioate
Thio(Ac) C6 amidite (BRP-00969)

Thio(Ac) C6 amidite

Description: Thio(Ac) C6 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with an acetyl (Ac) protecting group and a 6-carbon linker. This reagent enables the introduction of a thiol-modified linker with a 6-carbon chain length into oligonucleotide sequences during synthesis. Thiol modifications can be utilized for various applications such as covalent conjugation, labeling, or surface immobilization in bioassays.
CAT: BRP-00969
CAS: 176640-51-0
Molecular Formula: C17H33N2O3PS
Molecular Weight: 376.50
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: YYZTVJUOQPJPLL-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: N#CCCOP(OCCCCCCSC(=O)C)N(C(C)C)C(C)C
IUPAC Name: S-(6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl) ethanethioate
InChI: InChI=1S/C17H33N2O3PS/c1-15(2)19(16(3)4)23(22-13-10-11-18)21-12-8-6-7-9-14-24-17(5)20/h15-16H,6-10,12-14H2,1-5H3
Synonyms: Ethanethioic acid, S-[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ester; S-[6-[[[Bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ethanethioate
Thio(Ac)-PEG3 amidite (BRP-00970)

Thio(Ac)-PEG3 amidite

Description: Thio(Ac)-PEG3 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with an acetyl (Ac) protecting group and a polyethylene glycol (PEG) linker of three ethylene glycol units. This reagent allows for the introduction of a thiol-modified linker with a PEG3 spacer into oligonucleotide sequences during synthesis. Thiol modifications with PEG linkers are often employed for various applications such as covalent conjugation, labeling, or improving solubility and flexibility of oligonucleotides.
CAT: BRP-00970
CAS: 153870-21-4
Molecular Formula: C17H33N2O5PS
Molecular Weight: 408.50
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: FMIVUFGXNQLSTH-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCSC(=O)C
IUPAC Name: S-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethyl] ethanethioate
InChI: InChI=1S/C17H33N2O5PS/c1-15(2)19(16(3)4)25(23-8-6-7-18)24-12-11-21-9-10-22-13-14-26-17(5)20/h15-16H,6,8-14H2,1-5H3
Synonyms: Ethanethioic acid, S-[10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-3,6,9-trioxa-11-aza-10-phosphatridec-1-yl] ester; Ethanethioic acid, S-[10-[bis(1-methylethyl)amino]-13-cyano-3,6,9,11-tetraoxa-10-phosphatridec-1-yl] ester; S-[10-(2-Cyanoethoxy)-12-methyl-11-(1-methylethyl)-3,6,9-trioxa-11-aza-10-phosphatridec-1-yl] ethanethioate; S-(2-(2-(2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethoxy)ethyl) ethanethioate
UNA 2'-OBz C(Bz) amidite (BRP-00971)

UNA 2'-OBz C(Bz) amidite

Description: UNA 2'-OBz C(Bz) amidite is a reagent used in oligonucleotide synthesis, containing an Unlocked Nucleic Acid (UNA) backbone modification. In this designation, 2'-OBz indicates a benzoyl (Bz) protecting group at the 2' position of ribose, and C(Bz) indicates cytosine (C) protected with a benzoyl group. This reagent is utilized for synthesizing oligonucleotides with UNA backbone modifications, which increase the flexibility of the oligonucleotide backbone. UNA modifications can confer specific properties to oligonucleotides, such as altering hybridization behavior or enhancing nuclease resistance, suitable for various biotechnological applications.
CAT: BRP-00971
Molecular Formula: C53H58N5O10P
Molecular Weight: 956.05
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: MINLZVSGJNTMMR-OBHWIOKQSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R)-2-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(((2R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propan-2-yl)oxy)ethyl benzoate
InChI: InChI=1S/C53H58N5O10P/c1-38(2)58(39(3)4)69(66-34-16-32-54)67-36-47(35-65-53(42-21-14-9-15-22-42,43-23-27-45(62-5)28-24-43)44-25-29-46(63-6)30-26-44)68-49(37-64-51(60)41-19-12-8-13-20-41)57-33-31-48(56-52(57)61)55-50(59)40-17-10-7-11-18-40/h7-15,17-31,33,38-39,47,49H,16,34-37H2,1-6H3,(H,55,56,59,61)/t47-,49-,69?/m1/s1
Synonyms: N6-Bz-C-UNA-Phosphoramidite; 2'-OBz-N6-Bz-C-UNA-Phosphoramidite; 2'-OBz-C(Bz)-UNA-Phosphoramidite; 2'-OBz-C(Bz)-UNA-3'-CE-Phosphoramidite
2'-MOE PseudoUridine amidite (BRP-00972)

2'-MOE PseudoUridine amidite

Description: 2'-MOE PseudoUridine amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates PseudoUridine, a modified nucleoside resembling uridine. This allows for the synthesis of oligonucleotides containing PseudoUridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.
CAT: BRP-00972
CAS: 1417162-48-1
Molecular Formula: C42H53N4O10P
Molecular Weight: 804.88
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: QGENAASPFJKDDU-APSGJOCZSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: N#CCCOP(OC1C(OC(C2=CNC(=O)NC2=O)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C42H53N4O10P/c1-28(2)46(29(3)4)57(54-23-11-22-43)56-38-36(55-37(39(38)52-25-24-49-5)35-26-44-41(48)45-40(35)47)27-53-42(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-21,26,28-29,36-39H,11,23-25,27H2,1-7H3,(H2,44,45,47,48)/t36-,37+,38-,39+,57?/m1/s1
Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-(2-methoxyethyl)-β-D-ribofuranosyl]-; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-(2-methoxyethyl)-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione
2'-MOE N1-Methyl PseudoUridine amidite (BRP-00973)

2'-MOE N1-Methyl PseudoUridine amidite

Description: 2'-MOE N1-Methyl PseudoUridine amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates N1-Methyl PseudoUridine, a modified nucleoside resembling uridine with a methyl group attached to the nitrogen at position 1. It enables the synthesis of oligonucleotides containing N1-Methyl PseudoUridine modifications, offering specific properties or functionalities to the resulting oligonucleotides, suitable for various biotechnological applications.
CAT: BRP-00973
Molecular Formula: C43H55N4O10P
Molecular Weight: 818.91
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: FWVPZDATJBTJIH-SAAFSQBVSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H55N4O10P/c1-29(2)47(30(3)4)58(55-24-12-23-44)57-39-37(56-38(40(39)53-26-25-50-6)36-27-46(5)42(49)45-41(36)48)28-54-43(31-13-10-9-11-14-31,32-15-19-34(51-7)20-16-32)33-17-21-35(52-8)22-18-33/h9-11,13-22,27,29-30,37-40H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38+,39-,40+,58?/m1/s1
2'-OMe 5-Ethynyl-U amidite (BRP-00974)

2'-OMe 5-Ethynyl-U amidite

Description: 2'-OMe 5-Ethynyl-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates 5-Ethynyl-Uridine (5-Ethynyl-U), a modified uridine nucleoside with an ethynyl group attached at the 5-position of the uracil base. It allows for the synthesis of oligonucleotides containing 5-Ethynyl-Uridine modifications, which can be useful for various applications such as click chemistry reactions for further functionalization or conjugation.
CAT: BRP-00974
CAS: 2201814-30-2
Molecular Formula: C42H49N4O9P
Molecular Weight: 784.85
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: FTWDORGUPXUAIL-WDABSCDASA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: N#CCCOP(OC1C(OC(N2C=C(C#C)C(=O)NC2=O)C1OC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-ethynyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C42H49N4O9P/c1-9-30-26-45(41(48)44-39(30)47)40-38(51-8)37(55-56(53-25-13-24-43)46(28(2)3)29(4)5)36(54-40)27-52-42(31-14-11-10-12-15-31,32-16-20-34(49-6)21-17-32)33-18-22-35(50-7)23-19-33/h1,10-12,14-23,26,28-29,36-38,40H,13,25,27H2,2-8H3,(H,44,47,48)/t36-,37-,38-,40-,56?/m1/s1
2'-MOE 2-Thio-U amidite (BRP-00975)

2'-MOE 2-Thio-U amidite

Description: 2'-MOE 2-Thio-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates 2-Thio-Uridine (2-Thio-U), a modified uridine nucleoside with a sulfur atom (S) at the 2-position of the uracil base. It facilitates the synthesis of oligonucleotides containing 2-Thio-Uridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.
CAT: BRP-00975
CAS: 647839-25-6
Molecular Formula: C42H53N4O9PS
Molecular Weight: 820.95
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: PRCKCMMLZPXTNK-CYSIDSPMSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=CC(=O)NC2=S)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C42H53N4O9PS/c1-29(2)46(30(3)4)56(53-25-11-23-43)55-38-36(54-40(39(38)51-27-26-48-5)45-24-22-37(47)44-41(45)57)28-52-42(31-12-9-8-10-13-31,32-14-18-34(49-6)19-15-32)33-16-20-35(50-7)21-17-33/h8-10,12-22,24,29-30,36,38-40H,11,25-28H2,1-7H3,(H,44,47,57)/t36-,38-,39-,40-,56?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
2'-OMe 2-Thio-U amidite (BRP-00976)

2'-OMe 2-Thio-U amidite

Description: 2'-OMe 2-Thio-U amidite is a reagent employed in oligonucleotide synthesis. This reagent features a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates 2-Thio-Uridine (2-Thio-U), which is a modified uridine nucleoside with a sulfur atom (S) at the 2-position of the uracil base. It enables the synthesis of oligonucleotides containing 2-Thio-Uridine modifications. These modifications can confer specific properties or functionalities to the resulting oligonucleotides, suitable for various applications in biotechnology and molecular biology.
CAT: BRP-00976
CAS: 302918-84-9
Molecular Formula: C40H49N4O8PS
Molecular Weight: 776.89
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: DWDMFECIJNQDJC-GFIGKZKCSA-N
Solubility: Soluble in Acetonitrile, DMF
SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=S)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C40H49N4O8PS/c1-27(2)44(28(3)4)53(50-25-11-23-41)52-36-34(51-38(37(36)48-7)43-24-22-35(45)42-39(43)54)26-49-40(29-12-9-8-10-13-29,30-14-18-32(46-5)19-15-30)31-16-20-33(47-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,54)/t34-,36-,37-,38-,53?/m1/s1
Synonyms: 2'-O-Me-2-thio-U-3'-phosphoramidite; 2'-O-Me-s2U-3'-[2-cyanoethyl-N,N-diisopropylphosphoramidite]; 5'-O-DMTr-2'-O-methyl-2-thiouridine-3'-CED-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-2-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Me-2-thiouridine-3'-CE-Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyl-2-thiouridine-3'-cyanoethyl Phosphoramidite

Frequently Asked Questions (FAQ)

What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

* Only for research. Not suitable for any diagnostic or therapeutic use.

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