Phosphoramidites

LNA A(pac) amidite

Description: LNA A(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis, specifically for incorporating Locked Nucleic Acid (LNA) modifications into nucleic acid sequences. This modification involves attaching a phenoxyacetyl (pac) group to the adenine base of LNA. It is commonly used to enhance the binding affinity, stability, and specificity of oligonucleotides in various applications such as antisense therapy, PCR, and molecular diagnostics.

CAT: BRP-00813

Molecular Formula: C49H54N7O9P

Molecular Weight: 915.98

Purity: >98%

Appearance: Off-white solid

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InChIKey: RHUYJRYFCPQBIE-LXTWGDFWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(6-(2-phenoxyacetamido)-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H54N7O9P/c1-33(2)56(34(3)4)66(63-27-13-26-50)65-44-43-47(55-32-53-42-45(51-31-52-46(42)55)54-41(57)28-60-40-16-11-8-12-17-40)64-48(44,29-61-43)30-62-49(35-14-9-7-10-15-35,36-18-22-38(58-5)23-19-36)37-20-24-39(59-6)25-21-37/h7-12,14-25,31-34,43-44,47H,13,27-30H2,1-6H3,(H,51,52,54,57)/t43-,44+,47-,48-,66?/m1/s1

Synonyms: LNA A(pac) CE-Phosphoramidite; DMTr-LNA-A(pac)-3-CED-phosphoramidite

2'-OTFM U amidite

Description: 2'-OTFM U amidite is a modified phosphoramidite used in oligonucleotide synthesis, particularly for introducing 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences. This modification involves adding a trifluoromethyl group to the 2'-position of uridine. It is utilized to enhance the stability and specificity of RNA molecules in various applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00814

CAS: 869734-94-1

Molecular Formula: C40H46F3N4O9P

Molecular Weight: 814.79

Purity: >95%

Appearance: Off-white solid

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InChIKey: AIVSTWHGYKADBY-FNMBQTMFSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC(F)(F)F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-(trifluoromethoxy)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H46F3N4O9P/c1-26(2)47(27(3)4)57(53-24-10-22-44)56-35-33(54-37(36(35)55-40(41,42)43)46-23-21-34(48)45-38(46)49)25-52-39(28-11-8-7-9-12-28,29-13-17-31(50-5)18-14-29)30-15-19-32(51-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,45,48,49)/t33-,35-,36-,37-,57?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trifluoromethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

LNA G(iPr-pac) amidite

Description: LNA G(iPr-pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis, specifically for incorporating Locked Nucleic Acid (LNA) modifications into nucleic acid sequences. This modification involves attaching an isopropylphenoxyacetyl (iPr-pac) group to the guanine base of LNA. It is commonly used to enhance the stability, specificity, and binding affinity of oligonucleotides in various applications such as antisense therapy, PCR, and molecular diagnostics.

CAT: BRP-00815

Molecular Formula: C52H60N7O10P

Molecular Weight: 974.06

Purity: >95%

Appearance: Off-white solid

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InChIKey: FSLCFYFCVYNCAE-ZVOKJCSSSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H60N7O10P/c1-33(2)36-15-21-42(22-16-36)64-29-43(60)55-50-56-47-44(48(61)57-50)54-32-58(47)49-45-46(69-70(67-28-12-27-53)59(34(3)4)35(5)6)51(68-49,30-65-45)31-66-52(37-13-10-9-11-14-37,38-17-23-40(62-7)24-18-38)39-19-25-41(63-8)26-20-39/h9-11,13-26,32-35,45-46,49H,12,28-31H2,1-8H3,(H2,55,56,57,60,61)/t45-,46+,49-,51-,70?/m1/s1

Synonyms: LNA G(iPr-pac) CE-Phosphoramidite; DMTr-LNA-G(iPr-pac)-3-CED-phosphoramidite

2'-OTFM C(Ac) amidite

Description: 2'-OTFM C(Ac) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences, specifically targeting cytidine (C). This modification involves adding a trifluoromethyl group to the 2'-position of cytidine and acetylating the amino group of cytidine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00816

CAS: 869734-91-8

Molecular Formula: C42H49F3N5O9P

Molecular Weight: 855.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: VECFWZPFXRVLKY-HCIBFWJXSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC(F)(F)F)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(trifluoromethoxy)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C42H49F3N5O9P/c1-27(2)50(28(3)4)60(56-25-11-23-46)59-37-35(57-39(38(37)58-42(43,44)45)49-24-22-36(47-29(5)51)48-40(49)52)26-55-41(30-12-9-8-10-13-30,31-14-18-33(53-6)19-15-31)32-16-20-34(54-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,47,48,51,52)/t35-,37-,38-,39-,60?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trifluoromethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-OTFM C(Ac) CE-Phosphoramidite

2'-OTFM C(Bz) amidite

Description: 2'-OTFM C(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences, specifically targeting cytidine (C). This modification involves adding a trifluoromethyl group to the 2'-position of cytidine and benzoylating the amino group of cytidine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00817

Molecular Formula: C47H51F3N5O9P

Molecular Weight: 917.92

Purity: >95%

Appearance: Off-white solid

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InChIKey: APWVCZQYEKTHIH-WKNHZCODSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H51F3N5O9P/c1-31(2)55(32(3)4)65(61-29-13-27-51)64-41-39(62-44(42(41)63-47(48,49)50)54-28-26-40(53-45(54)57)52-43(56)33-14-9-7-10-15-33)30-60-46(34-16-11-8-12-17-34,35-18-22-37(58-5)23-19-35)36-20-24-38(59-6)25-21-36/h7-12,14-26,28,31-32,39,41-42,44H,13,29-30H2,1-6H3,(H,52,53,56,57)/t39-,41-,42-,44-,65?/m1/s1

Synonyms: 2'-OTFM C(Bz) CE-Phosphoramidite

2'-OTFM G(iBu) amidite

Description: 2'-OTFM G(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences, specifically targeting guanosine (G). This modification involves adding a trifluoromethyl group to the 2'-position of guanosine and attaching an isobutyl (iBu) group to the exocyclic amine of guanosine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00818

Molecular Formula: C45H53F3N7O9P

Molecular Weight: 923.93

Purity: >95%

Appearance: Off-white solid

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InChIKey: YINYCQLAYPBOSI-SDLFASLNSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC(F)(F)F

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(trifluoromethoxy)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C45H53F3N7O9P/c1-27(2)40(56)52-43-51-39-36(41(57)53-43)50-26-54(39)42-38(63-45(46,47)48)37(64-65(61-24-12-23-49)55(28(3)4)29(5)6)35(62-42)25-60-44(30-13-10-9-11-14-30,31-15-19-33(58-7)20-16-31)32-17-21-34(59-8)22-18-32/h9-11,13-22,26-29,35,37-38,42H,12,24-25H2,1-8H3,(H2,51,52,53,56,57)/t35-,37-,38-,42-,65?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-OTFM G(iBu) CE-Phosphoramidite

2'-OMe C(Ac) Me-amidite

Description: 2'-OMe C(Ac) Me-amidite is a modified phosphoramidite used in oligonucleotide synthesis, particularly for introducing 2'-O-methyl (2'-OMe) modifications into RNA sequences, specifically targeting cytidine (C). This modification involves adding a methyl group to the 2'-position of cytidine and acetylating the amino group of cytidine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00821

CAS: 205116-62-7

Molecular Formula: C40H51N4O8P

Molecular Weight: 746.84

Purity: >95%

Appearance: Off-white solid

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InChIKey: QRMLMMQHOYHYLD-GFIGKZKCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(N(C(C)C)C(C)C)C)C2OC)NC(=O)C

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C40H51N4O8P/c1-26(2)44(27(3)4)53(9)52-36-34(51-38(37(36)49-8)43-24-23-35(41-28(5)45)42-39(43)46)25-50-40(29-13-11-10-12-14-29,30-15-19-32(47-6)20-16-30)31-17-21-33(48-7)22-18-31/h10-24,26-27,34,36-38H,25H2,1-9H3,(H,41,42,45,46)/t34-,36-,37-,38-,53?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-OMe-C(Ac)-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-OMe-C-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Cytidine (n-acetyl) p-methyl phosphonamidite; 5'-O-DMTr-2'-OMe-C(Ac) methyl phosphonamidite

2'-OMe A(Bz) Me-amidite

Description: 2'-OMe A(Bz) Me-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-methyl (2'-OMe) modifications into RNA sequences, specifically targeting adenosine (A). This modification involves adding a methyl group to the 2'-position of adenosine and benzoylating the amino group of adenosine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00822

CAS: 158691-23-7

Molecular Formula: C46H53N6O7P

Molecular Weight: 832.94

Purity: >95%

Appearance: Off-white solid

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InChIKey: GICXOURJNDWAPG-NSWJMSGMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)C)C3OC)C=7C=CC=CC7

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C46H53N6O7P/c1-30(2)52(31(3)4)60(8)59-40-38(58-45(41(40)56-7)51-29-49-39-42(47-28-48-43(39)51)50-44(53)32-15-11-9-12-16-32)27-57-46(33-17-13-10-14-18-33,34-19-23-36(54-5)24-20-34)35-21-25-37(55-6)26-22-35/h9-26,28-31,38,40-41,45H,27H2,1-8H3,(H,47,48,50,53)/t38-,40-,41-,45-,60?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-OMe-A(Bz)-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-OMe-adenosine-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Adenosine (n-bz) p-methyl phosphonamidite; 5'-O-DMTr-2'-OMe-A(Bz) methyl phosphonamidite

2'-OMe G(iBu) Me-amidite

Description: 2'-OMe G(iBu) Me-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-methyl (2'-OMe) modifications into RNA sequences, specifically targeting guanosine (G). This modification involves adding a methyl group to the 2'-position of guanosine and attaching an isobutyl (iBu) group to the exocyclic amine of guanosine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00823

CAS: 191786-63-7

Molecular Formula: C43H55N6O8P

Molecular Weight: 814.92

Purity: >95%

Appearance: Off-white solid

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InChIKey: JAVHPGCWDJVLLN-BSQJSOGMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)C)C3OC

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C43H55N6O8P/c1-26(2)39(50)46-42-45-38-35(40(51)47-42)44-25-48(38)41-37(54-9)36(57-58(10)49(27(3)4)28(5)6)34(56-41)24-55-43(29-14-12-11-13-15-29,30-16-20-32(52-7)21-17-30)31-18-22-33(53-8)23-19-31/h11-23,25-28,34,36-37,41H,24H2,1-10H3,(H2,45,46,47,50,51)/t34-,36-,37-,41-,58?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-OMe-G(iBu)-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-OMe-G-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Guanosine (n-ibu) p-methyl phosphonamidite; 5'-O-DMTr-2'-OMe-G(iBu) methyl phosphonamidite

MMTr C7 amine amidite

Description: MMTr C7 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, allowing for the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C7 amine amidite plays a crucial role in the efficient and controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00824

Molecular Formula: C36H50N3O3P

Molecular Weight: 603.79

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: SESSADZGYXHMSJ-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-[7-[[(4-methoxyphenyl)-diphenylmethyl]amino]heptoxy]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C36H50N3O3P/c1-30(2)39(31(3)4)43(42-29-17-26-37)41-28-16-8-6-7-15-27-38-36(32-18-11-9-12-19-32,33-20-13-10-14-21-33)34-22-24-35(40-5)25-23-34/h9-14,18-25,30-31,38H,6-8,15-17,27-29H2,1-5H3

Synonyms: 2-cyanoethyl (7-(((4-methoxyphenyl)diphenylmethyl)amino)heptyl) diisopropylphosphoramidite; NHMMTr-C7 Phosphoramidite; Monomethoxytrityl-heptylamine-linker Phosphoramidite

MMTr C5 amine amidite

Description: MMTr C5 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, allowing the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C5 amine amidite plays a crucial role in the efficient and controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00825

CAS: 178811-39-7

Molecular Formula: C34H46N3O3P

Molecular Weight: 575.73

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: QKLNHYFSRTYCRA-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCCCCNC(C1=CC=C(OC)C=C1)(C2=CC=CC=C2)C3=CC=CC=C3

IUPAC Name: 2-cyanoethyl (5-(((4-methoxyphenyl)diphenylmethyl)amino)pentyl) diisopropylphosphoramidite

InChI: InChI=1S/C34H46N3O3P/c1-28(2)37(29(3)4)41(40-27-15-24-35)39-26-14-8-13-25-36-34(30-16-9-6-10-17-30,31-18-11-7-12-19-31)32-20-22-33(38-5)23-21-32/h6-7,9-12,16-23,28-29,36H,8,13-15,25-27H2,1-5H3

Synonyms: NHMMTr-C5 Phosphoramidite; Monomethoxytrityl-pentylamine-linker Phosphoramidite

MMTr C4 amine amidite

Description: MMTr C4 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, facilitating the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C4 amine amidite is essential for the controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00826

CAS: 178811-38-6

Molecular Formula: C33H44N3O3P

Molecular Weight: 561.71

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: LVYNYJLDPZLYCP-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCCCNC(C1=CC=C(OC)C=C1)(C2=CC=CC=C2)C3=CC=CC=C3

IUPAC Name: 2-cyanoethyl (4-(((4-methoxyphenyl)diphenylmethyl)amino)butyl) diisopropylphosphoramidite

InChI: InChI=1S/C33H44N3O3P/c1-27(2)36(28(3)4)40(39-26-14-23-34)38-25-13-12-24-35-33(29-15-8-6-9-16-29,30-17-10-7-11-18-30)31-19-21-32(37-5)22-20-31/h6-11,15-22,27-28,35H,12-14,24-26H2,1-5H3

Synonyms: NHMMTr-C4 Phosphoramidite; Monomethoxytrityl-butylamine-linker Phosphoramidite

MMTr C2 amine amidite

Description: MMTr C2 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, enabling the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C2 amine amidite is crucial for the controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00827

Molecular Formula: C31H40N3O3P

Molecular Weight: 533.65

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: TVYYYWLTEUUCSU-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC

IUPAC Name: 3-[[di(propan-2-yl)amino]-[2-[[(4-methoxyphenyl)-diphenylmethyl]amino]ethoxy]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C31H40N3O3P/c1-25(2)34(26(3)4)38(36-23-12-21-32)37-24-22-33-31(27-13-8-6-9-14-27,28-15-10-7-11-16-28)29-17-19-30(35-5)20-18-29/h6-11,13-20,25-26,33H,12,22-24H2,1-5H3

Synonyms: 2-cyanoethyl (2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl) diisopropylphosphoramidite; MMTr C2 linker Phosphoramidite; MMT-ethylamine-linker Phosphoramidite; NHMMTr-C2 Phosphoramidite

2'-OTBS U OMe-amidite

Description: 2'-OTBS U OMe-amidite is a reagent used for synthesizing modified oligonucleotides. It has uridine with a 2'-tert-butyldimethylsilyl (TBDMS) protecting group, which enhances stability during the synthesis process. This modification improves the stability and resistance of the oligonucleotides to degradation.

CAT: BRP-00828

CAS: 114207-67-9

Molecular Formula: C43H60N3O9PSi

Molecular Weight: 822.03

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: AJKMTCZXJSDRLN-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OC)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[[di(propan-2-yl)amino]-methoxyphosphanyl]oxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C43H60N3O9PSi/c1-29(2)46(30(3)4)56(51-10)54-38-36(53-40(45-27-26-37(47)44-41(45)48)39(38)55-57(11,12)42(5,6)7)28-52-43(31-16-14-13-15-17-31,32-18-22-34(49-8)23-19-32)33-20-24-35(50-9)25-21-33/h13-27,29-30,36,38-40H,28H2,1-12H3,(H,44,47,48)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite; 5'-O-DMTr-2'-O-TBDMS-U-3'-Methoxy-phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-uridine-3'-Methoxy-phosphoramidite; 2'-tBDSilyl Uridine methyl phosphoramidite

2'-OTBS C(Ac) OMe-amidite

Description: 2'-OTBS C(Ac) OMe-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-OTBS modifications into RNA sequences, specifically targeting cytidine (C). It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00830

CAS: 1360559-84-7

Molecular Formula: C45H63N4O9PSi

Molecular Weight: 863.08

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: TZHWOKHEMQAVPY-ZMHKPELYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2O[Si](C)(C)C(C)(C)C)NC(=O)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C45H63N4O9PSi/c1-30(2)49(31(3)4)59(54-11)57-40-38(56-42(41(40)58-60(12,13)44(6,7)8)48-28-27-39(46-32(5)50)47-43(48)51)29-55-45(33-17-15-14-16-18-33,34-19-23-36(52-9)24-20-34)35-21-25-37(53-10)26-22-35/h14-28,30-31,38,40-42H,29H2,1-13H3,(H,46,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-TBDMS-C(Ac)-3'-Methoxy-phosphoramidite; N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-cytidine-3'-Methoxy-phosphoramidite

2'-OTBS A(Bz) OMe-amidite

Description: 2'-OTBS A(Bz) OMe-amidite is a reagent for oligonucleotide synthesis. It features adenosine with a tert-butyldimethylsilyl (TBDMS) group at the 2'-position and a benzoyl (bz) group protecting the amino group. This compound is used to incorporate modified adenosine into synthetic oligonucleotides, enhancing their stability and resistance to degradation.

CAT: BRP-00831

CAS: 118684-39-2

Molecular Formula: C51H65N6O8PSi

Molecular Weight: 949.18

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: QECBNEWCSSUUAS-XOMUZYEBSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3O[Si](C)(C)C(C)(C)C)C=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C51H65N6O8PSi/c1-34(2)57(35(3)4)66(61-10)64-44-42(31-62-51(37-21-17-14-18-22-37,38-23-27-40(59-8)28-24-38)39-25-29-41(60-9)30-26-39)63-49(45(44)65-67(11,12)50(5,6)7)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-19-15-13-16-20-36/h13-30,32-35,42,44-45,49H,31H2,1-12H3,(H,52,53,55,58)/t42-,44-,45-,49-,66?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-TBDMS-A(Bz)-3'-Methoxy-phosphoramidite; 2'-tBDSilyl Adenosine (n-bz) methyl phosphoramidite

2'-OTBS G(iBu) OMe-amidite

Description: 2'-OTBS G(iBu) OMe-amidite is a reagent for synthesizing modified oligonucleotides. It features guanosine with a tert-butyldimethylsilyl (TBDMS) group at the 2'-position and an isobutyryl (ibu) group protecting the amino group. This modification enhances stability during synthesis and improves the resistance of oligonucleotides to degradation.

CAT: BRP-00832

CAS: 118684-41-6

Molecular Formula: C48H67N6O9PSi

Molecular Weight: 931.16

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: GQXDBSFXGQUFKG-VCGWOZLGSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3O[Si](C)(C)C(C)(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C48H67N6O9PSi/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(63-65(13,14)47(7,8)9)40(62-64(59-12)54(31(3)4)32(5)6)38(61-45)28-60-48(33-18-16-15-17-19-33,34-20-24-36(57-10)25-21-34)35-22-26-37(58-11)27-23-35/h15-27,29-32,38,40-41,45H,28H2,1-14H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,64?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-TBDMS-G(iBu)-3'-Methoxy-phosphoramidite; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-Methoxy-phosphoramidite; 2'-tBDSilyl Guanosine (n-ibu) methyl phosphoramidite

2'-OTBS 7,9-de-8-Thio-I amidite

Description: 2'-OTBS 7,9-de-8-Thio-I amidite is a modified phosphoramidite used in oligonucleotide synthesis. This modification can confer unique properties to oligonucleotides and is utilized in various applications in molecular biology and nucleic acid chemistry research.

CAT: BRP-00833

Molecular Formula: C47H61N4O8PSSi

Molecular Weight: 901.15

Purity: >98%

Appearance: Off-white solid

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InChIKey: ICUUKKNWPLMJGN-SRYSXPHVSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-oxo-3,4-dihydrothieno[3,4-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H61N4O8PSSi/c1-31(2)51(32(3)4)60(56-27-15-26-48)58-41-39(57-43(42(41)59-62(10,11)46(5,6)7)44-40-38(29-61-44)45(52)50-30-49-40)28-55-47(33-16-13-12-14-17-33,34-18-22-36(53-8)23-19-34)35-20-24-37(54-9)25-21-35/h12-14,16-25,29-32,39,41-43H,15,27-28H2,1-11H3,(H,49,50,52)/t39-,41-,42-,43-,60?/m1/s1

2'-O-NMA MeC(iBu) amidite

Description: 2'-O-NMA MeC(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. The modifications enhance the stability and specificity of RNA molecules and are commonly used in various molecular biology applications.

CAT: BRP-00834

Molecular Formula: C47H61N6O10P

Molecular Weight: 901.01

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: LAHCHMSIGMYPKH-LKYMEUIMSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-isobutyramido-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H61N6O10P/c1-30(2)44(55)50-43-33(7)27-52(46(56)51-43)45-42(59-29-40(54)49-8)41(63-64(61-26-14-25-48)53(31(3)4)32(5)6)39(62-45)28-60-47(34-15-12-11-13-16-34,35-17-21-37(57-9)22-18-35)36-19-23-38(58-10)24-20-36/h11-13,15-24,27,30-32,39,41-42,45H,14,26,28-29H2,1-10H3,(H,49,54)(H,50,51,55,56)/t39-,41-,42-,45-,64?/m1/s1

Synonyms: 5'-DMT-2'-O-NMA-5-Me-C(iBu)-3'-CE-Phosphoramidite; [4-N-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-5-methylcytidine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

PMO I Monomer

Description: PMO I monomer refers to a monomeric unit used in the synthesis of Phosphorodiamidate Morpholino Oligomers (PMOs). PMOs are synthetic nucleic acid analogs that are widely used in antisense therapy and molecular biology research. They are designed to hybridize with specific RNA sequences to modulate gene expression or function. The ''I'' monomer represents one of the nucleobase modifications that can be incorporated into PMOs to confer specific properties or enhance their binding affinity and specificity.

CAT: BRP-00835

CAS: 1044241-76-0

Molecular Formula: C31H32ClN6O4P

Molecular Weight: 619.06

Purity: >98%

Appearance: Off-white solid

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Density: 1.38±0.1 g/cm3

Boiling Point: 761.0±70.0 °C at 760 mmHg

InChIKey: YCFWIWLBQZCQQO-RXDNIKEDSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=CNC2=C1N=CN2C3OC(COP(=O)(Cl)N(C)C)CN(C3)C(C=4C=CC=CC4)(C=5C=CC=CC5)C=6C=CC=CC6

IUPAC Name: ((2S,6R)-6-(6-oxo-1,6-dihydro-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

InChI: InChI=1S/C31H32ClN6O4P/c1-36(2)43(32,40)41-20-26-18-37(19-27(42-26)38-22-35-28-29(38)33-21-34-30(28)39)31(23-12-6-3-7-13-23,24-14-8-4-9-15-24)25-16-10-5-11-17-25/h3-17,21-22,26-27H,18-20H2,1-2H3,(H,33,34,39)/t26-,27+,43?/m0/s1

Synonyms: Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-(1,6-dihydro-6-oxo-9H-purin-9-yl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester; [(2S,6R)-6-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate

LNA A(pac) amidite

2'-OTFM U amidite

LNA G(iPr-pac) amidite

2'-OTFM C(Ac) amidite

2'-OTFM C(Bz) amidite

2'-OTFM G(iBu) amidite

2'-OMe C(Ac) Me-amidite

2'-OMe A(Bz) Me-amidite

2'-OMe G(iBu) Me-amidite

MMTr C7 amine amidite

MMTr C5 amine amidite

MMTr C4 amine amidite

MMTr C2 amine amidite

2'-OTBS U OMe-amidite

2'-OTBS C(Ac) OMe-amidite

2'-OTBS A(Bz) OMe-amidite

2'-OTBS G(iBu) OMe-amidite

2'-OTBS 7,9-de-8-Thio-I amidite

2'-O-NMA MeC(iBu) amidite

PMO I Monomer

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