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Phosphoramidites

2'-Modified Phosphoramidites
(529/529)
2'-Phosphoramidites
(27/27)
3'-Modified Phosphoramidites
(201/201)
5'-Modified Phosphoramidites
(30/30)
Arabino Phosphoramidites
(23/23)
Base Protected Phosphoramidites (418/418) Dye Phosphoramidites
(53/53)
Label Phosphoramidites
(80/80)
Linker Phosphoramidites
(85/85)
Other Phosphoramidites
(97/97)
PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12)
Reverse Phosphoramidites
(25/25)
Spacer Phosphoramidites
(24/24)
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3'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-5'-CE-Phosphoramidite

Description: 3'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-5'-CE-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It contains a 3'-dimethoxytrityl (DMTr) protecting group on the 3' hydroxyl, a 2'-O-methoxyethyl (MOE) modification at the 2' position of the ribose sugar, a methyl (Me) modification at the 5' position of the cytosine base, and a benzoyl (Bz) protecting group on the cytosine amino group. Additionally, it features a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides, useful for various molecular biology research applications.
CAT: BRP-00592
CAS: 3025999-57-6
Molecular Formula: C50H60N5O10P
Molecular Weight: 922.03
Purity: ≥98%
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InChIKey: LGQSXYUXQBROPP-GICDFOIUSA-N
CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COP(N(C(C)C)C(C)C)OCCC#N)OC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OCCOC
IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-3-(2-methoxyethoxy)oxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C50H60N5O10P/c1-34(2)55(35(3)4)66(62-29-15-28-51)63-33-43-44(65-50(38-18-13-10-14-19-38,39-20-24-41(59-7)25-21-39)40-22-26-42(60-8)27-23-40)45(61-31-30-58-6)48(64-43)54-32-36(5)46(53-49(54)57)52-47(56)37-16-11-9-12-17-37/h9-14,16-27,32,34-35,43-45,48H,15,29-31,33H2,1-8H3,(H,52,53,56,57)/t43-,44-,45-,48-,66?/m1/s1
Synonyms: Rev 2'-O-MOE-5MeC(Bz)-5'-amidite; ((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(2-methoxyethoxy)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

3'-O-DMTr-2'-O-MOE-rA(Bz)-5'-CE-Phosphoramidite

Description: 3'-O-DMTr-2'-O-MOE-rA(Bz)-5'-CE-Phosphoramidite is a specialized nucleotide derivative used in oligonucleotide synthesis. It features a 3'-dimethoxytrityl (DMTr) protecting group on the 3' hydroxyl, a 2'-O-methoxyethyl (MOE) modification at the 2' position of the ribose sugar, and a benzoyl (Bz) protecting group on the adenine (A) base. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality, enabling controlled addition during synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides, making it valuable for molecular biology research applications.
CAT: BRP-00593
CAS: 3025999-68-9
Molecular Formula: C50H58N7O9P
Molecular Weight: 932.03
Purity: ≥95%
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InChIKey: XNXRGROTYZFYBK-HDMAWCRFSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)OCCOC)OC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-3-(2-methoxyethoxy)oxolan-2-yl]purin-6-yl]benzamide
InChI: InChI=1S/C50H58N7O9P/c1-34(2)57(35(3)4)67(63-28-14-27-51)64-31-42-44(66-50(37-17-12-9-13-18-37,38-19-23-40(60-6)24-20-38)39-21-25-41(61-7)26-22-39)45(62-30-29-59-5)49(65-42)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-15-10-8-11-16-36/h8-13,15-26,32-35,42,44-45,49H,14,28-31H2,1-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,67?/m1/s1
Synonyms: Rev 2'-O-MOE-A(Bz)-5'-amidite; ((2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(2-methoxyethoxy)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

3'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite

Description: 3'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite is a specialized nucleotide derivative used in oligonucleotide synthesis. It features a 3'-dimethoxytrityl (DMTr) protecting group on the 3' hydroxyl, a 2'-O-methoxyethyl (MOE) modification at the 2' position of the ribose sugar, and a benzoyl (Bz) protecting group on the adenine (A) base. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality, enabling controlled addition during synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides, making it valuable for molecular biology research applications.
CAT: BRP-00594
CAS: 725223-44-9
Molecular Formula: C47H60N7O10P
Molecular Weight: 914.00
Purity: ≥98%
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InChIKey: YLDSIMQFLQLTEA-SBCRAQIVSA-N
CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(N(C(C)C)C(C)C)OCCC#N)OC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OCCOC
IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-3-(2-methoxyethoxy)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
InChI: InChI=1S/C47H60N7O10P/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(60-27-26-57-7)40(38(63-45)28-62-65(61-25-13-24-48)54(31(3)4)32(5)6)64-47(33-14-11-10-12-15-33,34-16-20-36(58-8)21-17-34)35-18-22-37(59-9)23-19-35/h10-12,14-23,29-32,38,40-41,45H,13,25-28H2,1-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,65?/m1/s1
Synonyms: Rev 2'-O-MOE-G(iBu)-5'-amidite; Guanosine, 3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

U PMO Monomer

Description: U PMO Monomer is a monomer used in the synthesis of peptide-conjugated morpholino oligomers (PMO). PMOs are synthetic nucleic acid analogs designed for antisense therapy and gene expression modulation. The ''U'' designation indicates that the monomer is based on uracil, a nucleobase commonly used in nucleic acid analogs. These monomers are incorporated into PMOs to specifically target and bind complementary RNA sequences, thereby interfering with gene expression or splicing mechanisms.
CAT: BRP-00595
CAS: 2388517-98-2
Molecular Formula: C30H32ClN4O5P
Molecular Weight: 595.03
Purity: ≥98%
Appearance: White to faint yellow powder
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Density: 1.320±0.06 g/cm3
InChIKey: GCLNBTZDWZLIOP-JOLGRYLWSA-N
CanonicalSMILES: CN(C)P(=O)(OCC1CN(CC(O1)N2C=CC(=O)NC2=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)Cl
IUPAC Name: 1-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]pyrimidine-2,4-dione
InChI: InChI=1S/C30H32ClN4O5P/c1-33(2)41(31,38)39-22-26-20-34(21-28(40-26)35-19-18-27(36)32-29(35)37)30(23-12-6-3-7-13-23,24-14-8-4-9-15-24)25-16-10-5-11-17-25/h3-19,26,28H,20-22H2,1-2H3,(H,32,36,37)/t26-,28+,41?/m0/s1
Synonyms: ((2S,6R)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate; [(2S,6R)-6-(3,4-Dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate; Morpholino U

O6-(p-tolyl pivalate)-N2-PhAc protected G PMO Monomer

Description: O6-(p-tolyl pivalate)-N2-PhAc protected G PMO Monomer is a modified guanosine (G) monomer used in the synthesis of peptide-conjugated morpholino oligomers (PMO). It features a pivaloyloxymethyl (p-tolyl pivalate) group at the O6 position and a phenylacetyl (PhAc) group at the N2 position, providing protection to the guanine base during oligomer synthesis. PMOs are synthetic nucleic acid analogs designed for antisense therapy and gene expression modulation. These monomers are incorporated into PMOs to specifically target and bind complementary RNA sequences, thereby interfering with gene expression or splicing mechanisms.
CAT: BRP-00596
CAS: 1155309-89-9
Molecular Formula: C51H53ClN7O7P
Molecular Weight: 942.44
Purity: ≥98%
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Density: 1.29±0.1 g/cm3
InChIKey: TXKNJPOHRYJGGF-UHFFFAOYSA-N
CanonicalSMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)COC2=NC(=NC3=C2N=CN3C4CN(CC(O4)COP(=O)(N(C)C)Cl)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)NC(=O)CC8=CC=CC=C8
IUPAC Name: [4-[[9-[6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-2-[(2-phenylacetyl)amino]purin-6-yl]oxymethyl]phenyl] 2,2-dimethylpropanoate
InChI: InChI=1S/C51H53ClN7O7P/c1-50(2,3)48(61)66-41-28-26-37(27-29-41)33-63-47-45-46(55-49(56-47)54-43(60)30-36-18-10-6-11-19-36)59(35-53-45)44-32-58(31-42(65-44)34-64-67(52,62)57(4)5)51(38-20-12-7-13-21-38,39-22-14-8-15-23-39)40-24-16-9-17-25-40/h6-29,35,42,44H,30-34H2,1-5H3,(H,54,55,56,60)
Synonyms: Propanoic acid, 2,2-dimethyl-, 4-[[[9-[6-[[[chloro(dimethylamino)phosphinyl]oxy]methyl]-4-(triphenylmethyl)-2-morpholinyl]-2-[(2-phenylacetyl)amino]-9H-purin-6-yl]oxy]methyl]phenyl ester; Activated DPG Subunit; 4-[[[9-[6-[[[Chloro(dimethylamino)phosphinyl]oxy]methyl]-4-(triphenylmethyl)-2-morpholinyl]-2-[(2-phenylacetyl)amino]-9H-purin-6-yl]oxy]methyl]phenyl 2,2-dimethylpropanoate; PMO G(PhAc) Phosphoramidite

4-(((9-((2R,6S)-6-(((Chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-(2-phenylacetamido)-9H-purin-6-yl)oxy)methyl)phenyl pivalate

Description: 4-(((9-((2R,6S)-6-(((Chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-(2-phenylacetamido)-9H-purin-6-yl)oxy)methyl)phenyl pivalate is a complex molecular structure used in oligonucleotide synthesis. This structure likely serves as a protecting group or linker in the synthesis of nucleic acid analogs, enabling the controlled assembly of oligonucleotide sequences. The compound's design incorporates functionalities for efficient coupling reactions and protection of sensitive chemical groups during solid-phase synthesis.
CAT: BRP-00597
CAS: 1044241-66-8
Molecular Formula: C51H53ClN7O7P
Molecular Weight: 942.44
Purity: ≥98%
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Density: 1.29±0.1 g/cm3
InChIKey: TXKNJPOHRYJGGF-OHCUOHFYSA-N
CanonicalSMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)COC2=NC(=NC3=C2N=CN3C4CN(CC(O4)COP(=O)(N(C)C)Cl)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)NC(=O)CC8=CC=CC=C8
IUPAC Name: [4-[[9-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-2-[(2-phenylacetyl)amino]purin-6-yl]oxymethyl]phenyl] 2,2-dimethylpropanoate
InChI: InChI=1S/C51H53ClN7O7P/c1-50(2,3)48(61)66-41-28-26-37(27-29-41)33-63-47-45-46(55-49(56-47)54-43(60)30-36-18-10-6-11-19-36)59(35-53-45)44-32-58(31-42(65-44)34-64-67(52,62)57(4)5)51(38-20-12-7-13-21-38,39-22-14-8-15-23-39)40-24-16-9-17-25-40/h6-29,35,42,44H,30-34H2,1-5H3,(H,54,55,56,60)/t42-,44+,67?/m0/s1
Synonyms: Propanoic acid, 2,2-dimethyl-, 4-[[[9-[(2R,6S)-6-[[[chloro(dimethylamino)phosphinyl]oxy]methyl]-4-(triphenylmethyl)-2-morpholinyl]-2-[(2-phenylacetyl)amino]-9H-purin-6-yl]oxy]methyl]phenyl ester; 4-[[[9-[(2R,6S)-6-[[[Chloro(dimethylamino)phosphinyl]oxy]methyl]-4-(triphenylmethyl)-2-morpholinyl]-2-[(2-phenylacetyl)amino]-9H-purin-6-yl]oxy]methyl]phenyl 2,2-dimethylpropanoate; O6-(p-tolyl pivalate)-N2-PhAc protected G PMO Monomer

DMTr-2'-O-4'-C-ethylene-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-4'-C-ethylene-rU-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, exhibits increased stability and binding properties owing to the incorporation of an ethylene linker at the 2'-O and 4'-C positions of uridine (rU). The presence of a cyanoethyl (CE) group at the 3'-end facilitates efficient coupling reactions during solid-phase synthesis. It is particularly useful in the generation of modified RNA molecules for various biological applications, such as RNA interference (RNAi) and antisense therapy.
CAT: BRP-00598
CAS: 287737-49-9
Molecular Formula: C41H49N4O9P
Molecular Weight: 772.84
Purity: ≥98%
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InChIKey: WGXJDXATSZPKMD-JOFAAVELSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CCO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=O)NC6=O
IUPAC Name: 3-[[(1R,5R,7R,8S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-(2,4-dioxopyrimidin-1-yl)-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C41H49N4O9P/c1-28(2)45(29(3)4)55(52-25-10-23-42)54-37-36-38(44-24-21-35(46)43-39(44)47)53-40(37,22-26-50-36)27-51-41(30-11-8-7-9-12-30,31-13-17-33(48-5)18-14-31)32-15-19-34(49-6)20-16-32/h7-9,11-21,24,28-29,36-38H,10,22,25-27H2,1-6H3,(H,43,46,47)/t36-,37+,38-,40-,55?/m1/s1
Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-[2,6-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-; 1-[2,6-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-2,4(1H,3H)-pyrimidinedione; ENA-U Phosphoramidite

DMTr-2'-O-4'-C-ethylene-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-4'-C-ethylene-rC(Bz)-3'-CE-Phosphoramidite, employed in oligonucleotide synthesis, features an ethylene linker at the 2'-O and 4'-C positions of cytidine (rC), along with benzoyl (Bz) protection on the cytosine amino group. The cyanoethyl (CE) group at the 3'-end facilitates efficient coupling reactions during solid-phase synthesis. This modified nucleotide finds application in the creation of RNA sequences with enhanced stability and binding affinity, suitable for gene silencing studies and RNA-based therapeutics.
CAT: BRP-00599
CAS: 287737-36-4
Molecular Formula: C48H54N5O9P
Molecular Weight: 875.96
Purity: ≥98%
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InChIKey: IZEZSKXQKDNBEX-HAUVADMLSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CCO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=NC6=O)NC(=O)C7=CC=CC=C7
IUPAC Name: N-[1-[(1R,5R,7R,8S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-8-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,6-dioxabicyclo[3.2.1]octan-7-yl]-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C48H54N5O9P/c1-33(2)53(34(3)4)63(60-30-13-28-49)62-43-42-45(52-29-26-41(51-46(52)55)50-44(54)35-14-9-7-10-15-35)61-47(43,27-31-58-42)32-59-48(36-16-11-8-12-17-36,37-18-22-39(56-5)23-19-37)38-20-24-40(57-6)25-21-38/h7-12,14-26,29,33-34,42-43,45H,13,27,30-32H2,1-6H3,(H,50,51,54,55)/t42-,43+,45-,47-,63?/m1/s1
Synonyms: N-[1-[2,6-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]benzamide; (1R,5R,7R,8S)-7-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,6-dioxabicyclo[3.2.1]octan-8-yl (2-cyanoethyl) diisopropylphosphoramidite; ENA-C(Bz) Phosphoramidite

DMTr-2'-O-4'-C-ethylene-rA(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-4'-C-ethylene-rA(Bz)-3'-CE-Phosphoramidite, used in oligonucleotide synthesis, contains an ethylene linker at the 2'-O and 4'-C positions of adenosine (rA), with benzoyl (Bz) protection on the adenine amino group. The cyanoethyl (CE) group at the 3'-end facilitates efficient coupling reactions during solid-phase synthesis. It is employed in the construction of RNA sequences with augmented stability and binding affinity, suitable for various research applications including RNA-targeted therapy and gene expression modulation.
CAT: BRP-00600
CAS: 287737-45-5
Molecular Formula: C49H54N7O8P
Molecular Weight: 899.99
Purity: ≥98%
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InChIKey: IUGJZRODLODQAN-QLRWGQFGSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CCO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C(N=CN=C76)NC(=O)C8=CC=CC=C8
IUPAC Name: N-[9-[(1R,5R,7R,8S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-8-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,6-dioxabicyclo[3.2.1]octan-7-yl]purin-6-yl]benzamide
InChI: InChI=1S/C49H54N7O8P/c1-33(2)56(34(3)4)65(62-28-13-27-50)64-43-42-47(55-32-53-41-44(51-31-52-45(41)55)54-46(57)35-14-9-7-10-15-35)63-48(43,26-29-60-42)30-61-49(36-16-11-8-12-17-36,37-18-22-39(58-5)23-19-37)38-20-24-40(59-6)25-21-38/h7-12,14-25,31-34,42-43,47H,13,26,28-30H2,1-6H3,(H,51,52,54,57)/t42-,43+,47-,48-,65?/m1/s1
Synonyms: Benzamide, N-[9-[2,6-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-9H-purin-6-yl]-; ENA-A(bz) Phosphoramidite; N-[9-[2,6-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-9H-purin-6-yl]benzamide

DMTr-2'-O-4'-C-ethylene-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-4'-C-ethylene-rG(iBu)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, features an ethylene linker at the 2'-O and 4'-C positions of guanosine (rG), with isobutyryl (iBu) protection on the guanine amino group. The cyanoethyl (CE) group at the 3'-end facilitates efficient coupling reactions during solid-phase synthesis. This modified nucleotide is valuable for generating RNA sequences with enhanced stability and binding affinity, suitable for applications such as RNA interference (RNAi) and RNA therapeutics.
CAT: BRP-00601
CAS: 287737-58-0
Molecular Formula: C46H56N7O9P
Molecular Weight: 881.97
Purity: ≥98%
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InChIKey: VXCXNHPZXAIEDO-DNUXVXCXSA-N
CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C4C(C(O3)(CCO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: N-[9-[(1R,5R,7R,8S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-8-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,6-dioxabicyclo[3.2.1]octan-7-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
InChI: InChI=1S/C46H56N7O9P/c1-29(2)41(54)50-44-49-40-37(42(55)51-44)48-28-52(40)43-38-39(62-63(60-25-12-24-47)53(30(3)4)31(5)6)45(61-43,23-26-58-38)27-59-46(32-13-10-9-11-14-32,33-15-19-35(56-7)20-16-33)34-17-21-36(57-8)22-18-34/h9-11,13-22,28-31,38-39,43H,12,23,25-27H2,1-8H3,(H2,49,50,51,54,55)/t38-,39+,43-,45-,63?/m1/s1
Synonyms: ENA-G(iBu) Phosphoramidite; N-[9-[2,6-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methylpropanamide; (1R,5R,7R,8S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,6-dioxabicyclo[3.2.1]octan-8-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-C22-rA(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C22-rA(Bz)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, contains a DMTr protecting group at the 5'-position and a cyanoethyl (CE) group at the 3'-end. The nucleoside unit is adenosine (rA), modified with a C22 linker at the 2'-O position and benzoyl (Bz) protection on the adenine amino group. It is employed in the synthesis of RNA sequences with enhanced stability and binding affinity, suitable for various research applications including RNA-based therapy and gene expression modulation.
CAT: BRP-00603
CAS: 2923115-67-5
Molecular Formula: C69H96N7O8P
Molecular Weight: 1182.54
Purity: ≥98%
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InChIKey: BCBFIURHCBIJCZ-GOQGTMNZSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OCCCCCCCCCCCCCCCCCCCCCC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(docosyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C69H96N7O8P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-33-48-80-64-63(84-85(82-49-34-47-70)76(53(2)3)54(4)5)61(83-68(64)75-52-73-62-65(71-51-72-66(62)75)74-67(77)55-35-29-27-30-36-55)50-81-69(56-37-31-28-32-38-56,57-39-43-59(78-6)44-40-57)58-41-45-60(79-7)46-42-58/h27-32,35-46,51-54,61,63-64,68H,8-26,33-34,48-50H2,1-7H3,(H,71,72,74,77)/t61-,63-,64-,68-,85?/m1/s1

5'-O-DMT-2'-O-MOE-rG(iBu)-3'-((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite

Description: 5'-O-DMT-2'-O-MOE-rG(iBu)-3'-((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite, utilized in oligonucleotide synthesis, features a 5'-O-DMT protecting group and contains a diisopropylamino group for coupling with the next nucleotide. The nucleoside unit is guanosine (rG), modified with a 2'-O-methoxyethyl (MOE) group and isobutyryl (iBu) protection on the guanine amino group. It also contains a phosphoramidite group for solid-phase synthesis. It finds application in the construction of RNA sequences with enhanced stability and target specificity, suitable for various research applications including RNA-based therapeutics and gene editing.
CAT: BRP-00604
Molecular Formula: C55H78N8O12P2
Molecular Weight: 1105.22
Purity: ≥98%
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InChIKey: LVJZCNKMRFOXEH-XOHXKFSOSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethyl) diisopropylphosphoramidite
InChI: InChI=1S/C55H78N8O12P2/c1-36(2)51(64)59-54-58-50-47(52(65)60-54)57-35-61(50)53-49(69-31-30-66-11)48(75-77(63(39(7)8)40(9)10)73-33-32-72-76(71-29-17-28-56)62(37(3)4)38(5)6)46(74-53)34-70-55(41-18-15-14-16-19-41,42-20-24-44(67-12)25-21-42)43-22-26-45(68-13)27-23-43/h14-16,18-27,35-40,46,48-49,53H,17,29-34H2,1-13H3,(H2,58,59,60,64,65)/t46-,48-,49-,53-,76?,77?/m1/s1

5'-O-DMT-2'-O-MOE-5-Me-rC(Bz)-3'-((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite

Description: 5'-O-DMT-2'-O-MOE-5-Me-rC(Bz)-3'-((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite, employed in oligonucleotide synthesis, features a 5'-O-DMT protecting group and contains a diisopropylamino group for coupling with the next nucleotide. The nucleoside unit is 5-methylcytidine (5-Me-rC), modified with a 2'-O-methoxyethyl (MOE) group and benzoyl (Bz) protection on the cytosine amino group. Additionally, it contains a phosphoramidite group for solid-phase synthesis. The presence of a cyanoethoxy group at the 3'-end facilitates efficient coupling reactions during synthesis. This compound is valuable in generating modified RNA sequences with enhanced stability and target specificity, suitable for various research applications including RNA-based therapeutics and gene editing.
CAT: BRP-00605
Molecular Formula: C58H78N6O12P2
Molecular Weight: 1113.24
Purity: ≥98%
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InChIKey: GEBJJSSJUVBPKC-UBMNREJOSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethyl) diisopropylphosphoramidite
InChI: InChI=1S/C58H78N6O12P2/c1-40(2)63(41(3)4)77(72-33-19-32-59)73-36-37-74-78(64(42(5)6)43(7)8)76-52-51(39-71-58(46-22-17-14-18-23-46,47-24-28-49(68-11)29-25-47)48-26-30-50(69-12)31-27-48)75-56(53(52)70-35-34-67-10)62-38-44(9)54(61-57(62)66)60-55(65)45-20-15-13-16-21-45/h13-18,20-31,38,40-43,51-53,56H,19,33-37,39H2,1-12H3,(H,60,61,65,66)/t51-,52-,53-,56-,77?,78?/m1/s1

ethane-1,2-di(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-bis(diisopropylphosphoramidite)

Description: ethane-1,2-di(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-bis(diisopropylphosphoramidite) is employed in the solid-phase synthesis of oligonucleotides with specific modifications, enhancing their stability and target affinity for applications in molecular biology and biotechnology.
CAT: BRP-00606
Molecular Formula: C96H116N8O20P2
Molecular Weight: 1763.97
Purity: ≥92%
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InChIKey: ZRLNUNRPDXULMT-SUWRQQMKSA-N
IUPAC Name: bis((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) ethane-1,2-diyl bis(diisopropylphosphoramidite)
InChI: InChI=1S/C96H116N8O20P2/c1-63(2)103(64(3)4)125(123-83-81(61-117-95(71-33-25-19-26-34-71,73-37-45-77(111-13)46-38-73)74-39-47-78(112-14)48-40-74)121-91(85(83)115-55-53-109-11)101-59-67(9)87(99-93(101)107)97-89(105)69-29-21-17-22-30-69)119-57-58-120-126(104(65(5)6)66(7)8)124-84-82(62-118-96(72-35-27-20-28-36-72,75-41-49-79(113-15)50-42-75)76-43-51-80(114-16)52-44-76)122-92(86(84)116-56-54-110-12)102-60-68(10)88(100-94(102)108)98-90(106)70-31-23-18-24-32-70/h17-52,59-60,63-66,81-86,91-92H,53-58,61-62H2,1-16H3,(H,97,99,105,107)(H,98,100,106,108)/t81-,82-,83-,84-,85-,86-,91-,92-,125?,126?/m1/s1

ethane-1,2-di(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-bis(diisopropylphosphoramidite)

Description: ethane-1,2-di(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-bis(diisopropylphosphoramidite) is utilized in the solid-phase synthesis of oligonucleotides with specific modifications, enhancing their stability and target affinity for applications in molecular biology and biotechnology.
CAT: BRP-00607
Molecular Formula: C96H112N12O18P2
Molecular Weight: 1783.97
Purity: ≥92%
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InChIKey: JUHDGWSQBXOHFV-IFGMRGENSA-N
IUPAC Name: bis((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) ethane-1,2-diyl bis(diisopropylphosphoramidite)
InChI: InChI=1S/C96H112N12O18P2/c1-63(2)107(64(3)4)127(125-83-79(57-119-95(69-31-23-17-24-32-69,71-35-43-75(113-11)44-36-71)72-37-45-76(114-12)46-38-72)123-93(85(83)117-53-51-111-9)105-61-101-81-87(97-59-99-89(81)105)103-91(109)67-27-19-15-20-28-67)121-55-56-122-128(108(65(5)6)66(7)8)126-84-80(58-120-96(70-33-25-18-26-34-70,73-39-47-77(115-13)48-40-73)74-41-49-78(116-14)50-42-74)124-94(86(84)118-54-52-112-10)106-62-102-82-88(98-60-100-90(82)106)104-92(110)68-29-21-16-22-30-68/h15-50,59-66,79-80,83-86,93-94H,51-58H2,1-14H3,(H,97,99,103,109)(H,98,100,104,110)/t79-,80-,83-,84-,85-,86-,93-,94-,127?,128?/m1/s1

ethane-1,2-di(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-bis(diisopropylphosphoramidite)

Description: ethane-1,2-di(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-bis(diisopropylphosphoramidite) is employed in the solid-phase synthesis of oligonucleotides with specific modifications, enhancing their stability and target affinity for applications in molecular biology and biotechnology.
CAT: BRP-00608
Molecular Formula: C90H116N12O20P2
Molecular Weight: 1747.93
Purity: ≥92%
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InChIKey: DJTWFMQESYMPJM-FHQSMYATSA-N
IUPAC Name: bis((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) ethane-1,2-diyl bis(diisopropylphosphoramidite)
InChI: InChI=1S/C90H116N12O20P2/c1-55(2)81(103)95-87-93-79-73(83(105)97-87)91-53-99(79)85-77(113-47-45-107-13)75(71(119-85)51-115-89(61-25-21-19-22-26-61,63-29-37-67(109-15)38-30-63)64-31-39-68(110-16)40-32-64)121-123(101(57(5)6)58(7)8)117-49-50-118-124(102(59(9)10)60(11)12)122-76-72(120-86(78(76)114-48-46-108-14)100-54-92-74-80(100)94-88(98-84(74)106)96-82(104)56(3)4)52-116-90(62-27-23-20-24-28-62,65-33-41-69(111-17)42-34-65)66-35-43-70(112-18)44-36-66/h19-44,53-60,71-72,75-78,85-86H,45-52H2,1-18H3,(H2,93,95,97,103,105)(H2,94,96,98,104,106)/t71-,72-,75-,76-,77-,78-,85-,86-,123?,124?/m1/s1

di(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite)

Description: di(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite) consists of two molecules of 5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy connected by an ethane-1,2-diyl linker, with each end functionalized with a diisopropylphosphoramidite group. The guanosine (rG) nucleoside units are modified with a 2'-O-methoxyethyl (MOE) group and isobutyryl (iBu) protection on the guanine amino group. This compound is utilized in oligonucleotide synthesis for the introduction of guanosine modifications, enhancing stability and target specificity in RNA sequences.
CAT: BRP-00609
Molecular Formula: C92H120N12O21P2
Molecular Weight: 1791.98
Purity: ≥92%
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InChIKey: MSPWBBNFOKRACO-QBSMUBNASA-N
IUPAC Name: bis((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) (oxybis(ethane-2,1-diyl)) bis(diisopropylphosphoramidite)
InChI: InChI=1S/C92H120N12O21P2/c1-57(2)83(105)97-89-95-81-75(85(107)99-89)93-55-101(81)87-79(116-49-45-109-13)77(73(122-87)53-118-91(63-25-21-19-22-26-63,65-29-37-69(111-15)38-30-65)66-31-39-70(112-16)40-32-66)124-126(103(59(5)6)60(7)8)120-51-47-115-48-52-121-127(104(61(9)10)62(11)12)125-78-74(123-88(80(78)117-50-46-110-14)102-56-94-76-82(102)96-90(100-86(76)108)98-84(106)58(3)4)54-119-92(64-27-23-20-24-28-64,67-33-41-71(113-17)42-34-67)68-35-43-72(114-18)44-36-68/h19-44,55-62,73-74,77-80,87-88H,45-54H2,1-18H3,(H2,95,97,99,105,107)(H2,96,98,100,106,108)/t73-,74-,77-,78-,79-,80-,87-,88-,126?,127?/m1/s1

di(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite)

Description: di(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite) contains two molecules of 5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy linked by an ethane-1,2-diyl linker, with each end capped with a diisopropylphosphoramidite group. The adenosine (rA) nucleoside units are modified with a 2'-O-methoxyethyl (MOE) group and benzoyl (Bz) protection on the adenine amino group. It is employed in oligonucleotide synthesis to incorporate adenosine modifications, enhancing stability and target affinity in RNA sequences.
CAT: BRP-00610
Molecular Formula: C98H116N12O19P2
Molecular Weight: 1828.02
Purity: ≥92%
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InChIKey: HYMLNNFAMXTLQA-DEYJQIQZSA-N
IUPAC Name: bis((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) (oxybis(ethane-2,1-diyl)) bis(diisopropylphosphoramidite)
InChI: InChI=1S/C98H116N12O19P2/c1-65(2)109(66(3)4)130(128-85-81(59-122-97(71-31-23-17-24-32-71,73-35-43-77(115-11)44-36-73)74-37-45-78(116-12)46-38-74)126-95(87(85)120-55-51-113-9)107-63-103-83-89(99-61-101-91(83)107)105-93(111)69-27-19-15-20-28-69)124-57-53-119-54-58-125-131(110(67(5)6)68(7)8)129-86-82(60-123-98(72-33-25-18-26-34-72,75-39-47-79(117-13)48-40-75)76-41-49-80(118-14)50-42-76)127-96(88(86)121-56-52-114-10)108-64-104-84-90(100-62-102-92(84)108)106-94(112)70-29-21-16-22-30-70/h15-50,61-68,81-82,85-88,95-96H,51-60H2,1-14H3,(H,99,101,105,111)(H,100,102,106,112)/t81-,82-,85-,86-,87-,88-,95-,96-,130?,131?/m1/s1

di(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite)

Description: di(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite) features two molecules of 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy connected by an ethane-1,2-diyl linker, with each end bearing a diisopropylphosphoramidite group. The 5-methylcytidine (5-Me-rC) nucleoside units are modified with a 2'-O-methoxyethyl (MOE) group and benzoyl (Bz) protection on the cytosine amino group. It is utilized in oligonucleotide synthesis for introducing modified cytidine residues, enhancing stability and target specificity in RNA sequences.
CAT: BRP-00611
Molecular Formula: C98H120N8O21P2
Molecular Weight: 1808.02
Purity: ≥92%
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InChIKey: JOFMESXERKIMQK-AFYKGNOXSA-N
IUPAC Name: bis((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) (oxybis(ethane-2,1-diyl)) bis(diisopropylphosphoramidite)
InChI: InChI=1S/C98H120N8O21P2/c1-65(2)105(66(3)4)128(126-85-83(63-120-97(73-33-25-19-26-34-73,75-37-45-79(113-13)46-38-75)76-39-47-80(114-14)48-40-76)124-93(87(85)118-57-53-111-11)103-61-69(9)89(101-95(103)109)99-91(107)71-29-21-17-22-30-71)122-59-55-117-56-60-123-129(106(67(5)6)68(7)8)127-86-84(64-121-98(74-35-27-20-28-36-74,77-41-49-81(115-15)50-42-77)78-43-51-82(116-16)52-44-78)125-94(88(86)119-58-54-112-12)104-62-70(10)90(102-96(104)110)100-92(108)72-31-23-18-24-32-72/h17-52,61-62,65-68,83-88,93-94H,53-60,63-64H2,1-16H3,(H,99,101,107,109)(H,100,102,108,110)/t83-,84-,85-,86-,87-,88-,93-,94-,128?,129?/m1/s1

Bis(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-diisopropylphosphoramidite

Description: Bis(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-diisopropylphosphoramidite consists of two molecules of 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy linked by a diisopropylphosphoramidite group. Each 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy unit is equipped with a diisopropylphosphoramidite group, facilitating its integration into oligonucleotide synthesis. It is used to introduce modified 5-methylcytidine (5-Me-rC) residues into RNA sequences, enhancing stability and target specificity.
CAT: BRP-00612
Molecular Formula: C88H98N7O18P
Molecular Weight: 1572.73
Purity: ≥92%
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InChIKey: SISSXAOEXVVHFI-QEZASILESA-N
IUPAC Name: bis((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) diisopropylphosphoramidite
InChI: InChI=1S/C88H98N7O18P/c1-57(2)95(58(3)4)114(112-75-73(55-108-87(63-29-21-15-22-30-63,65-33-41-69(102-9)42-34-65)66-35-43-70(103-10)44-36-66)110-83(77(75)106-51-49-100-7)93-53-59(5)79(91-85(93)98)89-81(96)61-25-17-13-18-26-61)113-76-74(56-109-88(64-31-23-16-24-32-64,67-37-45-71(104-11)46-38-67)68-39-47-72(105-12)48-40-68)111-84(78(76)107-52-50-101-8)94-54-60(6)80(92-86(94)99)90-82(97)62-27-19-14-20-28-62/h13-48,53-54,57-58,73-78,83-84H,49-52,55-56H2,1-12H3,(H,89,91,96,98)(H,90,92,97,99)/t73-,74-,75-,76-,77-,78-,83-,84-/m1/s1
* Only for research. Not suitable for any diagnostic or therapeutic use.

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