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Phosphoramidites

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2'-Modified Phosphoramidites
(549/549) 2'-Phosphoramidites
(27/27) 3'-Modified Phosphoramidites
(201/201) 5'-Modified Phosphoramidites
(34/34) Arabino Phosphoramidites
(24/24) Base Protected Phosphoramidites (435/435) Dye Phosphoramidites
(63/63) Label Phosphoramidites
(81/81) Linker Phosphoramidites
(97/97) Other Phosphoramidites
(94/94) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(25/25) Spacer Phosphoramidites
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5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite is employed to introduce modified guanine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA structural studies, aptamer development, and gene regulation research.
CAT: BRP-00562
Molecular Formula: C37H59N7O13P2
Molecular Weight: 871.86
Purity: ≥98%
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InChIKey: BVJBAQGYDLYVPP-OGBCVAHGSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OC)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C
IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C37H59N7O13P2/c1-22(2)30(45)41-35-40-29-26(31(46)42-35)39-19-43(29)32-28(50-13)27(57-58(53-17-14-16-38)44(23(3)4)24(5)6)25(56-32)15-18-59(49,54-20-51-33(47)36(7,8)9)55-21-52-34(48)37(10,11)12/h15,18-19,22-25,27-28,32H,14,17,20-21H2,1-13H3,(H2,40,41,42,45,46)/b18-15+/t25-,27-,28-,32-,58?/m1/s1
Synonyms: 5'(E)-VP-2'-OMe-G(ibu)-CE-Phoshoramidite; 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite; 5'-(E)-VP-2'-OMe-G(iBu)-CE-Phoshoramidite

5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00563
Molecular Formula: C43H62N6O13P2
Molecular Weight: 932.95
Purity: ≥98%
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InChIKey: RKTQEWDKWSBILL-UQDZCBPASA-N
IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-4-methoxy-5-(6-(3-(3-methoxy-3-oxopropyl)phenyl)-9H-purin-9-yl)tetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C43H62N6O13P2/c1-28(2)49(29(3)4)63(58-21-14-20-44)62-36-32(19-22-64(53,59-26-56-40(51)42(5,6)7)60-27-57-41(52)43(8,9)10)61-39(37(36)55-12)48-25-47-35-34(45-24-46-38(35)48)31-16-13-15-30(23-31)17-18-33(50)54-11/h13,15-16,19,22-25,28-29,32,36-37,39H,14,17-18,21,26-27H2,1-12H3/b22-19+/t32-,36-,37-,39-,63?/m1/s1

DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-Phosphoramidite is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00564
CAS: 2379296-27-0
Molecular Formula: C51H51N6O10PS
Molecular Weight: 971.03
Purity: ≥98%
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InChIKey: GAVWOPVBQOSPKA-GPNGAECYSA-N
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OC)C=%10C=CC=CC%10
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1R,3R,3aR)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C51H51N6O10PS/c1-61-38-25-21-36(22-26-38)51(35-16-9-5-10-17-35,37-23-27-39(62-2)28-24-37)64-30-42-45(67-68-57-29-13-20-41(57)43(66-68)31-69(59,60)40-18-11-6-12-19-40)46(63-3)50(65-42)56-33-54-44-47(52-32-53-48(44)56)55-49(58)34-14-7-4-8-15-34/h4-12,14-19,21-28,32-33,41-43,45-46,50H,13,20,29-31H2,1-3H3,(H,52,53,55,58)/t41-,42-,43+,45-,46-,50-,68+/m1/s1
Synonyms: (D)-PSM-MA-RP; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-3'-O-[(1R,3R,3aR)-tetrahydro-3-[(phenylsulfonyl)methyl]-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]-

DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00565
CAS: 2379296-17-8
Molecular Formula: C51H51N6O10PS
Molecular Weight: 971.03
Purity: ≥98%
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InChIKey: GAVWOPVBQOSPKA-UKMMDQOKSA-N
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OC)C=%10C=CC=CC%10
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C51H51N6O10PS/c1-61-38-25-21-36(22-26-38)51(35-16-9-5-10-17-35,37-23-27-39(62-2)28-24-37)64-30-42-45(67-68-57-29-13-20-41(57)43(66-68)31-69(59,60)40-18-11-6-12-19-40)46(63-3)50(65-42)56-33-54-44-47(52-32-53-48(44)56)55-49(58)34-14-7-4-8-15-34/h4-12,14-19,21-28,32-33,41-43,45-46,50H,13,20,29-31H2,1-3H3,(H,52,53,55,58)/t41-,42+,43+,45+,46+,50+,68+/m0/s1
Synonyms: (L)-PSM-MA-RP; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-3'-O-[(1S,3S,3aS)-tetrahydro-3-[(phenylsulfonyl)methyl]-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]-

DMTr-2'-O-Me-rG(iBu)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rG(iBu)-3'-(L)-PSM-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00566
Molecular Formula: C48H53N6O11PS
Molecular Weight: 953.02
Purity: ≥98%
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InChIKey: QCPFOYJTUFIVGR-JADAPZILSA-N
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OC
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
InChI: InChI=1S/C48H53N6O11PS/c1-30(2)44(55)51-47-50-43-40(45(56)52-47)49-29-53(43)46-42(61-5)41(65-66-54-26-12-17-37(54)39(64-66)28-67(57,58)36-15-10-7-11-16-36)38(63-46)27-62-48(31-13-8-6-9-14-31,32-18-22-34(59-3)23-19-32)33-20-24-35(60-4)25-21-33/h6-11,13-16,18-25,29-30,37-39,41-42,46H,12,17,26-28H2,1-5H3,(H2,50,51,52,55,56)/t37-,38+,39+,41+,42+,46+,66+/m0/s1

DMTr-2'-O-Me-rU-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rU-3'-(L)-PSM-Phosphoramidite is used in oligonucleotide synthesis. It is employed to introduce modified uridine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00567
CAS: 2963598-67-4
Molecular Formula: C43H46N3O11PS
Molecular Weight: 843.88
Purity: ≥98%
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InChIKey: WALZCFCZIWHBMO-NRIQKVBLSA-N
CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP6OC(CS(=O)(=O)C=7C=CC=CC7)C8N6CCC8)C2OC
IUPAC Name: 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
InChI: InChI=1S/C43H46N3O11PS/c1-51-32-20-16-30(17-21-32)43(29-11-6-4-7-12-29,31-18-22-33(52-2)23-19-31)54-27-36-39(40(53-3)41(55-36)45-26-24-38(47)44-42(45)48)57-58-46-25-10-15-35(46)37(56-58)28-59(49,50)34-13-8-5-9-14-34/h4-9,11-14,16-24,26,35-37,39-41H,10,15,25,27-28H2,1-3H3,(H,44,47,48)/t35-,36+,37+,39+,40+,41+,58+/m0/s1
Synonyms: (L)-PSM-mU-Sp

DMTr-2'-O-Me-rC(Ac)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rC(Ac)-3'-(L)-PSM-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified cytidine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00568
Molecular Formula: C45H49N4O11PS
Molecular Weight: 884.94
Purity: ≥98%
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InChIKey: AOAKYUMILRMJOU-KNYXQZDESA-N
IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
InChI: InChI=1S/C45H49N4O11PS/c1-30(50)46-40-25-27-48(44(51)47-40)43-42(56-4)41(60-61-49-26-11-16-37(49)39(59-61)29-62(52,53)36-14-9-6-10-15-36)38(58-43)28-57-45(31-12-7-5-8-13-31,32-17-21-34(54-2)22-18-32)33-19-23-35(55-3)24-20-33/h5-10,12-15,17-25,27,37-39,41-43H,11,16,26,28-29H2,1-4H3,(H,46,47,50,51)/t37-,38+,39+,41+,42+,43+,61+/m0/s1

DMTr-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite is used in oligonucleotide synthesis. It is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00569
Molecular Formula: C51H59N6O9P
Molecular Weight: 931.04
Purity: ≥98%
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InChIKey: UYFASKQCDQCXQQ-MREAKBAOSA-N
IUPAC Name: methyl 3-(3-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)phenyl)propanoate
InChI: InChI=1S/C51H59N6O9P/c1-34(2)57(35(3)4)67(64-29-13-28-52)66-47-43(31-63-51(38-16-10-9-11-17-38,39-19-23-41(59-5)24-20-39)40-21-25-42(60-6)26-22-40)65-50(48(47)62-8)56-33-55-46-45(53-32-54-49(46)56)37-15-12-14-36(30-37)18-27-44(58)61-7/h9-12,14-17,19-26,30,32-35,43,47-48,50H,13,18,27,29,31H2,1-8H3/t43-,47-,48-,50-,67?/m1/s1

DMTr-2'-O-Me-N2,N6-Diibu-2-amido-rA-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Me-N2,N6-Diibu-2-amido-rA-3'-CE-Phosphoramidite is used in oligonucleotide synthesis. It is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00570
CAS: 160526-51-2
Molecular Formula: C49H63N8O9P
Molecular Weight: 939.06
Purity: ≥98%
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InChIKey: GBCWEEZHQVKVPU-FKYZNXHZSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC(=NC32)NC(=O)C(C)C)NC(=O)C(C)C)C1OC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,6-diisobutyramido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C49H63N8O9P/c1-30(2)45(58)52-43-40-44(54-48(53-43)55-46(59)31(3)4)56(29-51-40)47-42(62-11)41(66-67(64-27-15-26-50)57(32(5)6)33(7)8)39(65-47)28-63-49(34-16-13-12-14-17-34,35-18-22-37(60-9)23-19-35)36-20-24-38(61-10)25-21-36/h12-14,16-25,29-33,39,41-42,47H,15,27-28H2,1-11H3,(H2,52,53,54,55,58,59)/t39-,41-,42-,47-,67?/m1/s1
Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-2-[(2-methyl-1-oxopropyl)amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-2-[(2-methyl-1-oxopropyl)amino]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMTr-2'-O-MOE-rC(Ac)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOE-rC(Ac)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified cytidine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00572
Molecular Formula: C44H56N5O10P
Molecular Weight: 845.93
Purity: ≥98%
Appearance: White to off-white powder
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InChIKey: VSHRWOKGZWQVKY-FSEQMNGPSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C44H56N5O10P/c1-30(2)49(31(3)4)60(57-26-12-24-45)59-40-38(58-42(41(40)55-28-27-52-6)48-25-23-39(46-32(5)50)47-43(48)51)29-56-44(33-13-10-9-11-14-33,34-15-19-36(53-7)20-16-34)35-17-21-37(54-8)22-18-35/h9-11,13-23,25,30-31,38,40-42H,12,26-29H2,1-8H3,(H,46,47,50,51)/t38-,40-,41-,42-,60?/m1/s1
Synonyms: 5'-O-DMT-N4-Acetyl-2'-O-(2-methoxyethyl)cytidine 3'-CE phosphoramidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

DMTr-2'-O-MOE-rG(dmf)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOE-rG(dmf)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00573
Molecular Formula: C46H59N8O9P
Molecular Weight: 898.98
Purity: ≥98%
Appearance: Off-white solid
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InChIKey: IHRMKEYMVRZIQH-PFKWAGDCSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C46H59N8O9P/c1-31(2)54(32(3)4)64(61-25-13-24-47)63-40-38(62-44(41(40)59-27-26-56-7)53-30-48-39-42(53)50-45(51-43(39)55)49-29-52(5)6)28-60-46(33-14-11-10-12-15-33,34-16-20-36(57-8)21-17-34)35-18-22-37(58-9)23-19-35/h10-12,14-23,29-32,38,40-41,44H,13,25-28H2,1-9H3,(H,50,51,55)/t38-,40-,41-,44-,64?/m1/s1
Synonyms: 5'-O-DMT-2'-O-MOE-G(dmf)-CE Phosphoramidite; 2'-MOE G(dmf) amidite; DMT-2'-O-MOE-G(dmf)-CE-Phosphoramidite; N2-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine-3'-cyanoethyl Phosphoramidite

DMTr-2'-O-MOE-5-Me-rC-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOE-5-Me-rC-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified cytidine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00574
CAS: 251647-56-0
Molecular Formula: C43H56N5O9P
Molecular Weight: 817.92
Purity: ≥90%
Appearance: White to off-white powder
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InChIKey: FGTJXCRQSYSIEF-KZQAAKLLSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=NC2=O)N)C)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-5-(4-amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H56N5O9P/c1-29(2)48(30(3)4)58(55-24-12-23-44)57-38-37(56-41(39(38)53-26-25-50-6)47-27-31(5)40(45)46-42(47)49)28-54-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,27,29-30,37-39,41H,12,24-26,28H2,1-8H3,(H2,45,46,49)/t37-,38-,39-,41-,58?/m1/s1
Synonyms: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5-Me-5'-O-DMT-2'-O-MOE-Cr 3'-CE-Phosphoramidite; 5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl Phosphoramidite

DMTr-2'-O-MOE-5-Me-rC(DMTr)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOE-5-Me-rC(DMTr)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified cytidine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00575
Molecular Formula: C64H74N5O11P
Molecular Weight: 1120.29
Purity: ≥98%
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InChIKey: NHLNZHFBOBWWBL-XCWYBNAASA-N
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-((bis(4-methoxyphenyl)(phenyl)methyl)amino)-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C64H74N5O11P/c1-44(2)69(45(3)4)81(78-39-17-38-65)80-58-57(43-77-64(50-20-15-12-16-21-50,51-26-34-55(74-9)35-27-51)52-28-36-56(75-10)37-29-52)79-61(59(58)76-41-40-71-6)68-42-46(5)60(66-62(68)70)67-63(47-18-13-11-14-19-47,48-22-30-53(72-7)31-23-48)49-24-32-54(73-8)33-25-49/h11-16,18-37,42,44-45,57-59,61H,17,39-41,43H2,1-10H3,(H,66,67,70)/t57-,58-,59-,61-,81?/m1/s1

DMTr-2'-O-MOE-rG-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOE-rG-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00576
CAS: 1558023-79-2
Molecular Formula: C43H54N7O9P
Molecular Weight: 843.91
Purity: ≥98%
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InChIKey: BONZQXQXGMLHEM-USUFPPIWSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(N)NC32)C1OCCOC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H54N7O9P/c1-28(2)50(29(3)4)60(57-23-11-22-44)59-37-35(58-41(38(37)55-25-24-52-5)49-27-46-36-39(49)47-42(45)48-40(36)51)26-56-43(30-12-9-8-10-13-30,31-14-18-33(53-6)19-15-31)32-16-20-34(54-7)21-17-32/h8-10,12-21,27-29,35,37-38,41H,11,23-26H2,1-7H3,(H3,45,47,48,51)/t35-,37-,38-,41-,60?/m1/s1
Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMTr-2'-O-MOE-rG(DMTr)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOE-rG(DMTr)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00577
Molecular Formula: C64H72N7O11P
Molecular Weight: 1146.29
Purity: ≥95%
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InChIKey: RBJNKLVMRRLXHA-IDILFZDASA-N
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-((bis(4-methoxyphenyl)(phenyl)methyl)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C64H72N7O11P/c1-43(2)71(44(3)4)83(80-38-16-37-65)82-57-55(41-79-64(48-19-14-11-15-20-48,49-25-33-53(76-8)34-26-49)50-27-35-54(77-9)36-28-50)81-61(58(57)78-40-39-73-5)70-42-66-56-59(70)67-62(68-60(56)72)69-63(45-17-12-10-13-18-45,46-21-29-51(74-6)30-22-46)47-23-31-52(75-7)32-24-47/h10-15,17-36,42-44,55,57-58,61H,16,38-41H2,1-9H3,(H2,67,68,69,72)/t55-,57-,58-,61-,83?/m1/s1

DMTr-2'-O-MOE-rA-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOE-rA-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00578
CAS: 1558023-78-1
Molecular Formula: C43H54N7O8P
Molecular Weight: 827.91
Purity: ≥95% by HPLC
Appearance: White, off-white to faint yellow powder
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InChIKey: SMHLYNOCXUPBAV-NFQMNAKDSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)N)C1OCCOC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: 3-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C43H54N7O8P/c1-29(2)50(30(3)4)59(56-23-11-22-44)58-38-36(57-42(39(38)54-25-24-51-5)49-28-48-37-40(45)46-27-47-41(37)49)26-55-43(31-12-9-8-10-13-31,32-14-18-34(52-6)19-15-32)33-16-20-35(53-7)21-17-33/h8-10,12-21,27-30,36,38-39,42H,11,23-26H2,1-7H3,(H2,45,46,47)/t36-,38-,39-,42-,59?/m1/s1
Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite); Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; DMT-2'-O-MOE-Ar-CE-Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine-3'-cyanoethyl Phosphoramidite

DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite

Description: DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00579
Molecular Formula: C47H55N6O9P
Molecular Weight: 878.96
Purity: ≥98%
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InChIKey: QDIFFXPFBYESPR-QCDZHEALSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl hydrogen diisopropylphosphoramidite
InChI: InChI=1S/C47H55N6O9P/c1-31(2)53(32(3)4)63(55)62-41-39(28-60-47(34-16-12-9-13-17-34,35-18-22-37(57-6)23-19-35)36-20-24-38(58-7)25-21-36)61-46(42(41)59-27-26-56-5)52-30-50-40-43(48-29-49-44(40)52)51-45(54)33-14-10-8-11-15-33/h8-25,29-32,39,41-42,46,55H,26-28H2,1-7H3,(H,48,49,51,54)/t39-,41-,42-,46-,63?/m1/s1

DMTr-2'-O-MOE-rA(DMTr)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOE-rA(DMTr)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00580
Molecular Formula: C64H72N7O10P
Molecular Weight: 1130.29
Purity: ≥98%
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InChIKey: IOSMJVNZGCZZRX-LEYRIAGYSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=NC3=C(N=CN=C32)NC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)COC(C7=CC=CC=C7)(C8=CC=C(C=C8)OC)C9=CC=C(C=C9)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-[6-[[bis(4-methoxyphenyl)-phenylmethyl]amino]purin-9-yl]-4-(2-methoxyethoxy)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C64H72N7O10P/c1-44(2)71(45(3)4)82(79-38-16-37-65)81-58-56(41-78-64(49-19-14-11-15-20-49,50-25-33-54(75-8)34-26-50)51-27-35-55(76-9)36-28-51)80-62(59(58)77-40-39-72-5)70-43-68-57-60(66-42-67-61(57)70)69-63(46-17-12-10-13-18-46,47-21-29-52(73-6)30-22-47)48-23-31-53(74-7)32-24-48/h10-15,17-36,42-45,56,58-59,62H,16,38-41H2,1-9H3,(H,66,67,69)/t56-,58-,59-,62-,82?/m1/s1
Synonyms: (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-((bis(4-methoxyphenyl)(phenyl)methyl)amino)-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-MOE-rA(Bz)-3'-((2-cyanoethoxy)(diisopropylamino) phosphoramidite)-ethyl-diisopropylphosphoramidite

Description: DMTr-2'-O-MOE-rA(Bz)-3'-((2-cyanoethoxy)(diisopropylamino) phosphoramidite)-ethyl-diisopropylphosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00581
Molecular Formula: C58H76N8O11P2
Molecular Weight: 1123.24
Purity: ≥93%
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InChIKey: PAPVZRWLBSUSMQ-SXPYXJKBSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethyl) diisopropylphosphoramidite
InChI: InChI=1S/C58H76N8O11P2/c1-40(2)65(41(3)4)78(73-32-18-31-59)74-35-36-75-79(66(42(5)6)43(7)8)77-52-50(37-72-58(45-21-16-13-17-22-45,46-23-27-48(69-10)28-24-46)47-25-29-49(70-11)30-26-47)76-57(53(52)71-34-33-68-9)64-39-62-51-54(60-38-61-55(51)64)63-56(67)44-19-14-12-15-20-44/h12-17,19-30,38-43,50,52-53,57H,18,32-37H2,1-11H3,(H,60,61,63,67)/t50-,52-,53-,57-,78?,79?/m1/s1

DMTr-2'-O-MOE-rG(iBu)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-MOE-rG(iBu)-3'-(L)-PSM-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00582
CAS: 2379296-19-0
Molecular Formula: C50H57N6O12PS
Molecular Weight: 997.07
Purity: ≥98%
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InChIKey: BIELQCFHRDHWIK-VZEHQRRASA-N
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OCCOC
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-methoxyethoxy)-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
InChI: InChI=1S/C50H57N6O12PS/c1-32(2)46(57)53-49-52-45-42(47(58)54-49)51-31-55(45)48-44(64-28-27-61-3)43(68-69-56-26-12-17-39(56)41(67-69)30-70(59,60)38-15-10-7-11-16-38)40(66-48)29-65-50(33-13-8-6-9-14-33,34-18-22-36(62-4)23-19-34)35-20-24-37(63-5)25-21-35/h6-11,13-16,18-25,31-32,39-41,43-44,48H,12,17,26-30H2,1-5H3,(H2,52,53,54,57,58)/t39-,40+,41+,43+,44+,48+,69+/m0/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-3'-O-[(1S,3S,3aS)-tetrahydro-3-[(phenylsulfonyl)methyl]-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]-

Frequently Asked Questions (FAQ)

What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

* Only for research. Not suitable for any diagnostic or therapeutic use.

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