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Phosphoramidites

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2'-Modified Phosphoramidites
(529/529) 2'-Phosphoramidites
(27/27) 3'-Modified Phosphoramidites
(201/201) 5'-Modified Phosphoramidites
(30/30) Arabino Phosphoramidites
(23/23) Base Protected Phosphoramidites (418/418) Dye Phosphoramidites
(53/53) Label Phosphoramidites
(80/80) Linker Phosphoramidites
(85/85) Other Phosphoramidites
(97/97) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(25/25) Spacer Phosphoramidites
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Palmitate Phosphoramidite

Description: Palmitate Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce palmitic acid moieties into the oligonucleotide sequence. Palmitic acid is a saturated fatty acid commonly found in biological membranes and is known for its amphipathic properties. By attaching palmitic acid to oligonucleotides, researchers can modify the properties of the resulting conjugates, such as enhancing membrane permeability or promoting lipid bilayer interactions. This modification enables the development of oligonucleotide-based therapeutics, drug delivery systems, and molecular probes with improved cellular uptake and stability.
CAT: BRP-00546
CAS: 1772522-18-5
Molecular Formula: C31H62N3O3P
Molecular Weight: 555.82
Purity: ≥90% by HPLC
Appearance: White to off-white solid
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Storage: Store at -20 °C
InChIKey: BFUDAHSNZSPONN-UHFFFAOYSA-N
CanonicalSMILES: CCCCCCCCCCCCCCCC(=O)NCCCCCCOP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]hexadecanamide
InChI: InChI=1S/C31H62N3O3P/c1-6-7-8-9-10-11-12-13-14-15-16-17-20-24-31(35)33-26-21-18-19-22-27-36-38(37-28-23-25-32)34(29(2)3)30(4)5/h29-30H,6-24,26-28H2,1-5H3,(H,33,35)
Synonyms: Palmityl-6-aminohexyl [(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 6-[(1-oxohexadecyl)amino]hexyl ester; 2-Cyanoethyl 6-[(1-oxohexadecyl)amino]hexyl N,N-bis(1-methylethyl)phosphoramidite; Palmitic Aminohexanol Amidite; 2-cyanoethyl (6-palmitamidohexyl) diisopropylphosphoramidite; Palmitic Aminohexanol Phosphoramidite

Stearyl Phosphoramidite

Description: Stearyl Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a stearyl group (octadecyl chain) at the 5'-end of the oligonucleotide sequence. Stearyl groups are long-chain fatty acids that enhance the hydrophobicity and lipophilicity of the oligonucleotide, improving its ability to interact with lipid membranes. This modification is beneficial for developing oligonucleotide-based therapeutics and delivery systems, as it can enhance cellular uptake and stability. Stearyl-modified oligonucleotides are often used in gene silencing, antisense therapies, and other applications requiring efficient delivery and cellular internalization.
CAT: BRP-00547
CAS: 207273-84-5
Molecular Formula: C27H55N2O2P
Molecular Weight: 470.71
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InChIKey: KZQNEBQNUQNMRG-UHFFFAOYSA-N
CanonicalSMILES: CCCCCCCCCCCCCCCCCCOP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: 3-[[di(propan-2-yl)amino]-octadecoxyphosphanyl]oxypropanenitrile
InChI: InChI=1S/C27H55N2O2P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-24-30-32(31-25-22-23-28)29(26(2)3)27(4)5/h26-27H,6-22,24-25H2,1-5H3
Synonyms: 1-Octadecanol CEP; C18-linker amidite; Octadecyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl octadecyl ester; 5'-Stearyl phosphoramidite

Asymmetric Doubler (Lev) Phosphoramidite

Description: Asymmetric Doubler (Lev) Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce an asymmetric doubler modification into the oligonucleotide sequence. This modification features a levulinyl (Lev) protecting group, which provides additional control during the synthesis process. The asymmetric doubler facilitates the incorporation of two nucleotides in a single coupling step, improving synthesis efficiency and allowing for the introduction of unique structural or functional properties. This reagent is valuable for creating complex oligonucleotide structures and is used in various applications, including the development of therapeutic oligonucleotides, advanced molecular probes, and functional nucleic acids for research and diagnostic purposes.
CAT: BRP-00548
CAS: 2195357-46-9
Molecular Formula: C48H67N4O10P
Molecular Weight: 891.04
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Storage: Store at -20 °C
InChIKey: QREZMNJRLYXRTD-UHFFFAOYSA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CNC(=O)CCCCOC(=O)CCC(=O)C)CNC(=O)CCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC
IUPAC Name: [5-[[3-[5-[bis(4-methoxyphenyl)-phenylmethoxy]pentanoylamino]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]amino]-5-oxopentyl] 4-oxopentanoate
InChI: InChI=1S/C48H67N4O10P/c1-36(2)52(37(3)4)63(61-33-15-30-49)62-44(34-50-45(54)18-11-13-31-59-47(56)29-20-38(5)53)35-51-46(55)19-12-14-32-60-48(39-16-9-8-10-17-39,40-21-25-42(57-6)26-22-40)41-23-27-43(58-7)28-24-41/h8-10,16-17,21-28,36-37,44H,11-15,18-20,29,31-35H2,1-7H3,(H,50,54)(H,51,55)
Synonyms: 1-[5-(4,4'-dimethoxytrityloxy)pentylamido]-3-[5-levulinyloxypentylamido]-propyl-2-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Pentanoic acid, 4-oxo-, 8-[[[5-[bis(4-methoxyphenyl)phenylmethoxy]-1-oxopentyl]amino]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-5-oxo-9-oxa-6,11-diaza-10-phosphatridec-1-yl ester; 8-[[[5-[Bis(4-methoxyphenyl)phenylmethoxy]-1-oxopentyl]amino]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-5-oxo-9-oxa-6,11-diaza-10-phosphatridec-1-yl 4-oxopentanoate

Universal-CE Phosphoramidite

Description: Universal-CE Phosphoramidite is a versatile reagent used in oligonucleotide synthesis. It is designed to be incorporated at any position within the oligonucleotide sequence, providing a universal solution for a variety of modifications. This phosphoramidite enables the attachment of different functional groups or linkers to the oligonucleotide, facilitating applications such as labeling, conjugation, and immobilization. Its flexibility makes it particularly useful in research and diagnostic applications where customization of the oligonucleotide sequence is required. The Universal-CE Phosphoramidite enhances the efficiency and adaptability of the oligonucleotide synthesis process, supporting the development of tailored nucleic acid-based tools and therapeutics.
CAT: BRP-00549
CAS: 730963-37-8
Molecular Formula: C23H36N3O8P
Molecular Weight: 513.52
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Storage: Store at -20 °C
InChIKey: CBZZWACFDATALS-LTPKXJDNNA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: N#CCCOP(OCCCN1C(=O)C2C3OC(C4OC(OC)(OC43)C)C2C1=O)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl (3-((2r,3aR,4R,4aR,7aS,8S,8aS)-2-methoxy-2-methyl-5,7-dioxooctahydro-6H-4,8-epoxy[1,3]dioxolo[4,5-f]isoindol-6-yl)propyl) diisopropylphosphoramidite
InChI: InChI=1/C23H36N3O8P/c1-13(2)26(14(3)4)35(30-11-7-9-24)31-12-8-10-25-21(27)15-16(22(25)28)18-20-19(17(15)32-18)33-23(5,29-6)34-20/h13-20H,7-8,10-12H2,1-6H3/t15-,16+,17-,18+,19-,20+,23+,35?
Synonyms: 3-[(3aR,4R,5R,6S,7S)-6-(4,4'-dimethoxytrityloxy)-5-acetoxy-1-,3-dioxooctahydro-1H-4,7-epoxyisoindol-2-yl]propyl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 3-[(2α,3aα,4β,4aα,7aα,8β,8aα)-octahydro-2-methoxy-2-methyl-5,7-dioxo-4,8-epoxy-6H-1,3-dioxolo[4,5-f]isoindol-6-yl]propyl ester

DMTr-2'-O-TBDMS-rA(Bz)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-TBDMS-rA(Bz)-3'-(L)-PSM-Phosphoramidite is a compound used in oligonucleotide synthesis. It protects adenine (rA) at the 5'-position with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it attaches a benzoyl (Bz) group to the adenine base and introduces a 3'-(L)-PSM modifier at the 3'-end. This compound enables precise synthesis of oligonucleotides with specific modifications for various applications.
CAT: BRP-00555
Molecular Formula: C56H63N6O10PSSi
Molecular Weight: 1071.27
Purity: ≥98%
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InChIKey: JEWOWPFMMHAFMF-KDYSEBNISA-N
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C56H63N6O10PSSi/c1-55(2,3)75(6,7)72-50-49(71-73-62-33-17-24-45(62)47(70-73)35-74(64,65)44-22-15-10-16-23-44)46(69-54(50)61-37-59-48-51(57-36-58-52(48)61)60-53(63)38-18-11-8-12-19-38)34-68-56(39-20-13-9-14-21-39,40-25-29-42(66-4)30-26-40)41-27-31-43(67-5)32-28-41/h8-16,18-23,25-32,36-37,45-47,49-50,54H,17,24,33-35H2,1-7H3,(H,57,58,60,63)/t45-,46+,47+,49+,50+,54+,73+/m0/s1

DMTr-2'-O-TBDMS-rA(Bz)-3'-(D)-PSM-Phosphoramidite

Description: DMTr-2'-O-TBDMS-rA(Bz)-3'-(D)-PSM-Phosphoramidite is a chemical compound used in oligonucleotide synthesis. It protects adenine (rA) at the 5'-position with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it attaches a benzoyl (Bz) group to the adenine base. The 3'-(D)-PSM modifier introduces a functional group at the 3'-end of the oligonucleotide. This compound allows for controlled synthesis of customized oligonucleotides for various applications in molecular biology and biotechnology.
CAT: BRP-00556
Molecular Formula: C56H63N6O10PSSi
Molecular Weight: 1071.27
Purity: ≥98%
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InChIKey: JEWOWPFMMHAFMF-OPURRIEGSA-N
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((1R,3R,3aR)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C56H63N6O10PSSi/c1-55(2,3)75(6,7)72-50-49(71-73-62-33-17-24-45(62)47(70-73)35-74(64,65)44-22-15-10-16-23-44)46(69-54(50)61-37-59-48-51(57-36-58-52(48)61)60-53(63)38-18-11-8-12-19-38)34-68-56(39-20-13-9-14-21-39,40-25-29-42(66-4)30-26-40)41-27-31-43(67-5)32-28-41/h8-16,18-23,25-32,36-37,45-47,49-50,54H,17,24,33-35H2,1-7H3,(H,57,58,60,63)/t45-,46-,47+,49-,50-,54-,73+/m1/s1

DMTr-2'-O-TBDMS-5-Cl-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-Cl-rU-3'-CE-Phosphoramidite is a chemical compound used in oligonucleotide synthesis. It protects the 5'-hydroxyl group with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it incorporates 5-chloro-uridine as a modified nucleoside. The 3'-CE phosphoramidite facilitates nucleotide addition during synthesis. This compound allows for the controlled synthesis of oligonucleotides with specific modifications, important for various applications in molecular biology and biotechnology.
CAT: BRP-00558
Molecular Formula: C45H60ClN4O9PSi
Molecular Weight: 895.50
Purity: ≥98%
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InChIKey: RRACSVOLQAOFCZ-IPXQPGKOSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)Cl)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-chloro-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C45H60ClN4O9PSi/c1-30(2)50(31(3)4)60(56-27-15-26-47)58-39-38(57-42(40(39)59-61(10,11)44(5,6)7)49-28-37(46)41(51)48-43(49)52)29-55-45(32-16-13-12-14-17-32,33-18-22-35(53-8)23-19-33)34-20-24-36(54-9)25-21-34/h12-14,16-25,28,30-31,38-40,42H,15,27,29H2,1-11H3,(H,48,51,52)/t38-,39-,40-,42-,60?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-chloro-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-TBDMS-5-F-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-F-rU-3'-CE-Phosphoramidite is a chemical compound utilized in oligonucleotide synthesis. It safeguards the 5'-hydroxyl group with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it incorporates 5-fluoro-uridine as a modified nucleoside. The 3'-CE phosphoramidite facilitates nucleotide addition during synthesis. This compound enables precise control over oligonucleotide synthesis, essential for various applications in molecular biology and biotechnology.
CAT: BRP-00559
CAS: 173241-78-6
Molecular Formula: C45H60FN4O9PSi
Molecular Weight: 879.05
Purity: ≥98%
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InChIKey: MKGOHNKOHNRJLF-IPXQPGKOSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)F)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C45H60FN4O9PSi/c1-30(2)50(31(3)4)60(56-27-15-26-47)58-39-38(57-42(40(39)59-61(10,11)44(5,6)7)49-28-37(46)41(51)48-43(49)52)29-55-45(32-16-13-12-14-17-32,33-18-22-35(53-8)23-19-33)34-20-24-36(54-9)25-21-34/h12-14,16-25,28,30-31,38-40,42H,15,27,29H2,1-11H3,(H,48,51,52)/t38-,39-,40-,42-,60?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-fluoro-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5-Fluoro Uridine CED phosphoramidite

DMTr-2'-O-TBDMS-5-OMe-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-OMe-rU-3'-CE-Phosphoramidite is employed in oligonucleotide synthesis and features a TBDMS (tert-butyldimethylsilyl) group at the 2'-O position, and a methoxy (OMe) group on the uracil (rU) nucleoside. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is used to introduce modified uracil residues with increased stability and altered base pairing properties into nucleic acid sequences, suitable for various research applications including RNA structural studies, aptamer development, and gene regulation research.
CAT: BRP-00560
Molecular Formula: C46H63N4O10PSi
Molecular Weight: 891.09
Purity: ≥98%
Appearance: White, off-white to faint yellow powder
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InChIKey: OWTUZLAYUDYRNE-ACYYXZCMSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)OC)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-methoxy-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C46H63N4O10PSi/c1-31(2)50(32(3)4)61(57-28-16-27-47)59-40-39(58-43(41(40)60-62(11,12)45(5,6)7)49-29-38(55-10)42(51)48-44(49)52)30-56-46(33-17-14-13-15-18-33,34-19-23-36(53-8)24-20-34)35-21-25-37(54-9)26-22-35/h13-15,17-26,29,31-32,39-41,43H,16,28,30H2,1-12H3,(H,48,51,52)/t39-,40-,41-,43-,61?/m1/s1
Synonyms: 5'-O-DMTr-2'-O-TBDMS-5-methoxyuridine-3'-(cyanoethyl-N,N-diisopropyl)phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methoxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMT-2'-O-TBDMS-5-OMe-Ur Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-5-O-methyl-Uridine 3'-cyanoethyl Phosphoramidite

5'-POM-(E)-vinyl phosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite is employed to introduce modified cytosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00561
Molecular Formula: C39H57N5O13P2
Molecular Weight: 865.85
Purity: ≥98%
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InChIKey: JCWBJBRNLLVLQY-ZUZGDNAQSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OC)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C
IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C39H57N5O13P2/c1-26(2)44(27(3)4)58(53-22-15-20-40)57-31-29(19-23-59(49,54-24-51-35(46)38(5,6)7)55-25-52-36(47)39(8,9)10)56-34(32(31)50-11)43-21-18-30(42-37(43)48)41-33(45)28-16-13-12-14-17-28/h12-14,16-19,21,23,26-27,29,31-32,34H,15,22,24-25H2,1-11H3,(H,41,42,45,48)/b23-19+/t29-,31-,32-,34-,58?/m1/s1

5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite is employed to introduce modified guanine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA structural studies, aptamer development, and gene regulation research.
CAT: BRP-00562
Molecular Formula: C37H59N7O13P2
Molecular Weight: 871.86
Purity: ≥98%
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InChIKey: BVJBAQGYDLYVPP-OGBCVAHGSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OC)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C
IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C37H59N7O13P2/c1-22(2)30(45)41-35-40-29-26(31(46)42-35)39-19-43(29)32-28(50-13)27(57-58(53-17-14-16-38)44(23(3)4)24(5)6)25(56-32)15-18-59(49,54-20-51-33(47)36(7,8)9)55-21-52-34(48)37(10,11)12/h15,18-19,22-25,27-28,32H,14,17,20-21H2,1-13H3,(H2,40,41,42,45,46)/b18-15+/t25-,27-,28-,32-,58?/m1/s1
Synonyms: 5'(E)-VP-2'-OMe-G(ibu)-CE-Phoshoramidite; 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite; 5'-(E)-VP-2'-OMe-G(iBu)-CE-Phoshoramidite

5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00563
Molecular Formula: C43H62N6O13P2
Molecular Weight: 932.95
Purity: ≥98%
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InChIKey: RKTQEWDKWSBILL-UQDZCBPASA-N
IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-4-methoxy-5-(6-(3-(3-methoxy-3-oxopropyl)phenyl)-9H-purin-9-yl)tetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C43H62N6O13P2/c1-28(2)49(29(3)4)63(58-21-14-20-44)62-36-32(19-22-64(53,59-26-56-40(51)42(5,6)7)60-27-57-41(52)43(8,9)10)61-39(37(36)55-12)48-25-47-35-34(45-24-46-38(35)48)31-16-13-15-30(23-31)17-18-33(50)54-11/h13,15-16,19,22-25,28-29,32,36-37,39H,14,17-18,21,26-27H2,1-12H3/b22-19+/t32-,36-,37-,39-,63?/m1/s1

DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-Phosphoramidite is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00564
CAS: 2379296-27-0
Molecular Formula: C51H51N6O10PS
Molecular Weight: 971.03
Purity: ≥98%
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InChIKey: GAVWOPVBQOSPKA-GPNGAECYSA-N
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OC)C=%10C=CC=CC%10
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1R,3R,3aR)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C51H51N6O10PS/c1-61-38-25-21-36(22-26-38)51(35-16-9-5-10-17-35,37-23-27-39(62-2)28-24-37)64-30-42-45(67-68-57-29-13-20-41(57)43(66-68)31-69(59,60)40-18-11-6-12-19-40)46(63-3)50(65-42)56-33-54-44-47(52-32-53-48(44)56)55-49(58)34-14-7-4-8-15-34/h4-12,14-19,21-28,32-33,41-43,45-46,50H,13,20,29-31H2,1-3H3,(H,52,53,55,58)/t41-,42-,43+,45-,46-,50-,68+/m1/s1
Synonyms: (D)-PSM-MA-RP; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-3'-O-[(1R,3R,3aR)-tetrahydro-3-[(phenylsulfonyl)methyl]-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]-

DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00565
CAS: 2379296-17-8
Molecular Formula: C51H51N6O10PS
Molecular Weight: 971.03
Purity: ≥98%
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InChIKey: GAVWOPVBQOSPKA-UKMMDQOKSA-N
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OC)C=%10C=CC=CC%10
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C51H51N6O10PS/c1-61-38-25-21-36(22-26-38)51(35-16-9-5-10-17-35,37-23-27-39(62-2)28-24-37)64-30-42-45(67-68-57-29-13-20-41(57)43(66-68)31-69(59,60)40-18-11-6-12-19-40)46(63-3)50(65-42)56-33-54-44-47(52-32-53-48(44)56)55-49(58)34-14-7-4-8-15-34/h4-12,14-19,21-28,32-33,41-43,45-46,50H,13,20,29-31H2,1-3H3,(H,52,53,55,58)/t41-,42+,43+,45+,46+,50+,68+/m0/s1
Synonyms: (L)-PSM-MA-RP; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-3'-O-[(1S,3S,3aS)-tetrahydro-3-[(phenylsulfonyl)methyl]-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]-

DMTr-2'-O-Me-rG(iBu)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rG(iBu)-3'-(L)-PSM-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00566
Molecular Formula: C48H53N6O11PS
Molecular Weight: 953.02
Purity: ≥98%
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InChIKey: QCPFOYJTUFIVGR-JADAPZILSA-N
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OC
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
InChI: InChI=1S/C48H53N6O11PS/c1-30(2)44(55)51-47-50-43-40(45(56)52-47)49-29-53(43)46-42(61-5)41(65-66-54-26-12-17-37(54)39(64-66)28-67(57,58)36-15-10-7-11-16-36)38(63-46)27-62-48(31-13-8-6-9-14-31,32-18-22-34(59-3)23-19-32)33-20-24-35(60-4)25-21-33/h6-11,13-16,18-25,29-30,37-39,41-42,46H,12,17,26-28H2,1-5H3,(H2,50,51,52,55,56)/t37-,38+,39+,41+,42+,46+,66+/m0/s1

DMTr-2'-O-Me-rU-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rU-3'-(L)-PSM-Phosphoramidite is used in oligonucleotide synthesis. It is employed to introduce modified uridine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00567
CAS: 2963598-67-4
Molecular Formula: C43H46N3O11PS
Molecular Weight: 843.88
Purity: ≥98%
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InChIKey: WALZCFCZIWHBMO-NRIQKVBLSA-N
CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP6OC(CS(=O)(=O)C=7C=CC=CC7)C8N6CCC8)C2OC
IUPAC Name: 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
InChI: InChI=1S/C43H46N3O11PS/c1-51-32-20-16-30(17-21-32)43(29-11-6-4-7-12-29,31-18-22-33(52-2)23-19-31)54-27-36-39(40(53-3)41(55-36)45-26-24-38(47)44-42(45)48)57-58-46-25-10-15-35(46)37(56-58)28-59(49,50)34-13-8-5-9-14-34/h4-9,11-14,16-24,26,35-37,39-41H,10,15,25,27-28H2,1-3H3,(H,44,47,48)/t35-,36+,37+,39+,40+,41+,58+/m0/s1
Synonyms: (L)-PSM-mU-Sp

DMTr-2'-O-Me-rC(Ac)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rC(Ac)-3'-(L)-PSM-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified cytidine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00568
Molecular Formula: C45H49N4O11PS
Molecular Weight: 884.94
Purity: ≥98%
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InChIKey: AOAKYUMILRMJOU-KNYXQZDESA-N
IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
InChI: InChI=1S/C45H49N4O11PS/c1-30(50)46-40-25-27-48(44(51)47-40)43-42(56-4)41(60-61-49-26-11-16-37(49)39(59-61)29-62(52,53)36-14-9-6-10-15-36)38(58-43)28-57-45(31-12-7-5-8-13-31,32-17-21-34(54-2)22-18-32)33-19-23-35(55-3)24-20-33/h5-10,12-15,17-25,27,37-39,41-43H,11,16,26,28-29H2,1-4H3,(H,46,47,50,51)/t37-,38+,39+,41+,42+,43+,61+/m0/s1

DMTr-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite is used in oligonucleotide synthesis. It is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00569
Molecular Formula: C51H59N6O9P
Molecular Weight: 931.04
Purity: ≥98%
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InChIKey: UYFASKQCDQCXQQ-MREAKBAOSA-N
IUPAC Name: methyl 3-(3-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)phenyl)propanoate
InChI: InChI=1S/C51H59N6O9P/c1-34(2)57(35(3)4)67(64-29-13-28-52)66-47-43(31-63-51(38-16-10-9-11-17-38,39-19-23-41(59-5)24-20-39)40-21-25-42(60-6)26-22-40)65-50(48(47)62-8)56-33-55-46-45(53-32-54-49(46)56)37-15-12-14-36(30-37)18-27-44(58)61-7/h9-12,14-17,19-26,30,32-35,43,47-48,50H,13,18,27,29,31H2,1-8H3/t43-,47-,48-,50-,67?/m1/s1

DMTr-2'-O-Me-N2,N6-Diibu-2-amido-rA-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Me-N2,N6-Diibu-2-amido-rA-3'-CE-Phosphoramidite is used in oligonucleotide synthesis. It is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00570
CAS: 160526-51-2
Molecular Formula: C49H63N8O9P
Molecular Weight: 939.06
Purity: ≥98%
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InChIKey: GBCWEEZHQVKVPU-FKYZNXHZSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC(=NC32)NC(=O)C(C)C)NC(=O)C(C)C)C1OC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,6-diisobutyramido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C49H63N8O9P/c1-30(2)45(58)52-43-40-44(54-48(53-43)55-46(59)31(3)4)56(29-51-40)47-42(62-11)41(66-67(64-27-15-26-50)57(32(5)6)33(7)8)39(65-47)28-63-49(34-16-13-12-14-17-34,35-18-22-37(60-9)23-19-35)36-20-24-38(61-10)25-21-36/h12-14,16-25,29-33,39,41-42,47H,15,27-28H2,1-11H3,(H2,52,53,54,55,58,59)/t39-,41-,42-,47-,67?/m1/s1
Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-2-[(2-methyl-1-oxopropyl)amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-2-[(2-methyl-1-oxopropyl)amino]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-POM-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite is used in oligonucleotide synthesis. It is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00571
CAS: 2419895-65-9
Molecular Formula: C40H57N7O12P2
Molecular Weight: 889.88
Purity: ≥98%
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InChIKey: DCUPCJOKPAHCLB-OZKJWBRJSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OC)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C
IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C40H57N7O12P2/c1-26(2)47(27(3)4)60(55-20-15-19-41)59-31-29(18-21-61(51,56-24-53-37(49)39(5,6)7)57-25-54-38(50)40(8,9)10)58-36(32(31)52-11)46-23-44-30-33(42-22-43-34(30)46)45-35(48)28-16-13-12-14-17-28/h12-14,16-18,21-23,26-27,29,31-32,36H,15,20,24-25H2,1-11H3,(H,42,43,45,48)/b21-18+/t29-,31-,32-,36-,60?/m1/s1
Synonyms: N-[9-[(5E)-6-[Bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5,6-dideoxy-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-9H-purin-6-yl]benzamide; (E)-VP-2'-OMe-A(Bz)-CE-Phosphoramidite; (E)-Vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite; 5'-VP-2'-0Me-A(Bz)-CE-Phosphoramidite; (E)-5'-VP-2'-0Me-A(Bz)-CE-Phosphoramidite
* Only for research. Not suitable for any diagnostic or therapeutic use.

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