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Phosphoramidites

2'-Modified Phosphoramidites
(535/535)
2'-Phosphoramidites
(27/27)
3'-Modified Phosphoramidites
(201/201)
5'-Modified Phosphoramidites
(34/34)
Arabino Phosphoramidites
(24/24)
Base Protected Phosphoramidites (423/423) Dye Phosphoramidites
(64/64)
Label Phosphoramidites
(81/81)
Linker Phosphoramidites
(91/91)
Other Phosphoramidites
(93/93)
PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12)
Reverse Phosphoramidites
(25/25)
Spacer Phosphoramidites
(24/24)
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5'-Amino-Modifier TEG PDA

Description: 5'-Amino-Modifier TEG PDA introduces an amino group at the 5'-end of the oligonucleotide sequence, using a phosphoramidite backbone and a triethylene glycol (TEG) linker structure. The amino group allows for conjugation with other molecules or surfaces, while the TEG linker provides flexibility and solubility, reducing potential steric hindrance and improving accessibility for conjugation reactions. This modification is commonly used in applications such as nucleic acid labeling, surface functionalization, and bioconjugation strategies in molecular biology and biotechnology.
CAT: BRP-00541
CAS: 1445745-28-7
Molecular Formula: C26H43N4O7P
Molecular Weight: 554.62
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Storage: Store at -20 °C
InChIKey: BXAGTOOYWXHIHA-UHFFFAOYSA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCNC(=O)C1=CC=CC=C1C(=O)NC
IUPAC Name: 2-N-[2-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethoxy]ethyl]-1-N-methylbenzene-1,2-dicarboxamide
InChI: InChI=1S/C26H43N4O7P/c1-21(2)30(22(3)4)38(36-13-8-11-27)37-20-19-35-18-17-34-16-15-33-14-12-29-26(32)24-10-7-6-9-23(24)25(31)28-5/h6-7,9-10,21-22H,8,12-20H2,1-5H3,(H,28,31)(H,29,32)
Synonyms: 10-(N2-methylphthalimidyl-N1-ethyl)-triethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 13-[2-[(methylamino)carbonyl]phenyl]-13-oxo-3,6,9-trioxa-12-azatridec-1-yl ester

5'-Biotin II Phosphoramidite

Description: 5'-Biotin II Phosphoramidite is a reagent used in oligonucleotide synthesis to attach biotin at the 5'-end of the oligonucleotide sequence. Biotin is a small molecule known for its strong binding affinity to streptavidin or avidin proteins, enabling applications such as nucleic acid detection, protein purification, and surface functionalization. This modification allows specific and versatile binding to streptavidin or avidin-conjugated molecules, facilitating various molecular biology and biotechnology applications.
CAT: BRP-00542
Molecular Formula: C44H60N5O7PS
Molecular Weight: 834.03
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Storage: Store at -20 °C
InChIKey: HGIPHLWGZYGYEZ-IILKRBAMSA-N
Solubility: Soluble in Anhydrous Acetonitrile
IUPAC Name: 2-(2-(5-((3aS,4S,6aR)-1-(bis(4-methoxyphenyl)(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C44H60N5O7PS/c1-32(2)49(33(3)4)57(55-27-12-25-45)56-30-29-54-28-26-46-41(50)16-11-10-15-40-42-39(31-58-40)48(43(51)47-42)44(34-13-8-7-9-14-34,35-17-21-37(52-5)22-18-35)36-19-23-38(53-6)24-20-36/h7-9,13-14,17-24,32-33,39-40,42H,10-12,15-16,26-31H2,1-6H3,(H,46,50)(H,47,51)/t39-,40-,42-,57?/m0/s1
Synonyms: [1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-aminoethoxyethyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite

Acridine Phosphoramidite

Description: Acridine Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce acridine moieties into the oligonucleotide sequence. Acridine derivatives are known for their unique fluorescence properties, making them valuable for applications such as nucleic acid labeling, detection, and imaging. By incorporating acridine moieties into oligonucleotides, researchers can develop probes and molecular tools for studying DNA/RNA structure, dynamics, and interactions. This modification enables sensitive detection and visualization of nucleic acids in various biological assays and techniques, including fluorescence microscopy, in situ hybridization, and nucleic acid-based sensors.
CAT: BRP-00543
CAS: 402829-33-8
Molecular Formula: C51H60ClN4O6P
Molecular Weight: 891.47
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Storage: Store at -20 °C
InChIKey: IVSKHMOVPUZDIM-UHFFFAOYSA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(CCCCNC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: 3-[[2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-[(6-chloro-2-methoxyacridin-9-yl)amino]hexoxy]-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C51H60ClN4O6P/c1-36(2)56(37(3)4)63(61-31-13-29-53)62-35-38(14-11-12-30-54-50-46-27-21-42(52)32-49(46)55-48-28-26-45(59-7)33-47(48)50)34-60-51(39-15-9-8-10-16-39,40-17-22-43(57-5)23-18-40)41-19-24-44(58-6)25-20-41/h8-10,15-28,32-33,36-38H,11-14,30-31,34-35H2,1-7H3,(H,54,55)
Synonyms: 1-Dimethoxytrityloxy-2-(N-acridinyl-4-aminobutyl)-propyl-3-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[(6-chloro-2-methoxy-9-acridinyl)amino]hexyl 2-cyanoethyl ester; 2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[(6-chloro-2-methoxy-9-acridinyl)amino]hexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[(6-chloro-2-methoxy-9-acridinyl)amino]hexyl 2-cyanoethyl ester

5'-GalNAc C3 Phosphoramidite

Description: 5'-GalNAc C3 Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce N-acetylgalactosamine (GalNAc) at the 5'-end of the oligonucleotide sequence. GalNAc is a carbohydrate moiety commonly found in glycoproteins and glycolipids and is involved in various biological processes, including cell signaling and immune response modulation. By attaching GalNAc to oligonucleotides, researchers can develop molecular probes and therapeutics targeting specific carbohydrate-binding proteins, such as lectins and receptors. This modification enables the study of carbohydrate-protein interactions and the development of oligonucleotide-based drugs for therapeutic applications, including gene regulation, RNA interference, and targeted delivery.
CAT: BRP-00544
CAS: 2437303-51-8
Molecular Formula: C62H88N5O17P
Molecular Weight: 1206.36
Purity: >98%
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Storage: Store at 2-8 °C
Boiling Point: 819.6±65.0 °C at 760 mmHg
InChIKey: CBVYXTMIYQCOPE-KDYLSCEUSA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1(CCN(CC1)C(=O)CCCCCNC(=O)CCCOC2C(C(C(C(O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)COC(C3=CC=C(C=C3)OC)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: [(2R,3R,4R,5R,6R)-5-acetamido-3,4-diacetyloxy-6-[4-[[6-[4-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-[tris(4-methoxyphenyl)methoxymethyl]piperidin-1-yl]-6-oxohexyl]amino]-4-oxobutoxy]oxan-2-yl]methyl acetate
InChI: InChI=1S/C62H88N5O17P/c1-42(2)67(43(3)4)85(80-38-16-33-63)81-41-61(40-79-62(48-19-25-51(74-9)26-20-48,49-21-27-52(75-10)28-22-49)50-23-29-53(76-11)30-24-50)31-35-66(36-32-61)56(73)18-13-12-14-34-64-55(72)17-15-37-77-60-57(65-44(5)68)59(83-47(8)71)58(82-46(7)70)54(84-60)39-78-45(6)69/h19-30,42-43,54,57-60H,12-18,31-32,34-41H2,1-11H3,(H,64,72)(H,65,68)/t54-,57-,58+,59-,60-,85?/m1/s1
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl [1-[1-oxo-6-[[1-oxo-4-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]butyl]amino]hexyl]-4-[[tris(4-methoxyphenyl)methoxy]methyl]-4-piperidinyl]methyl ester; (2R,3R,4R,5R,6R)-5-Acetamido-2-(acetoxymethyl)-6-(4-((6-(4-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)-4-((tris(4-methoxyphenyl)methoxy)methyl)piperidin-1-yl)-6-oxohexyl)amino)-4-oxobutoxy)tetrahydro-2H-pyran-3,4-diyl diacetate; (4-(Trimethoxytrityloxymethyl)-1-(6-(4-(3,4,6-O-triacetyl-2-acetylamino-2-deoxy-β-D-galactopyranosyl)butanamido)hexanoyl)piperidin-4-yl)methyl-O-[(2-cyanoethyl)-(N,N-diisopropyl)] phosphoramidite

α-Tocopherol-TEG Phosphoramidite

Description: α-Tocopherol-TEG Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce α-tocopherol (vitamin E) molecules into the oligonucleotide sequence. α-Tocopherol is a potent antioxidant known for its protective effects against oxidative stress and its potential health benefits. The addition of α-tocopherol to oligonucleotides imparts antioxidant properties to the resulting conjugates, making them suitable for applications such as protecting nucleic acids from degradation during storage or amplification processes. Additionally, the presence of a triethylene glycol (TEG) linker enhances solubility and flexibility, facilitating conjugation and improving the stability of the oligonucleotide conjugates. This modification enables the development of oligonucleotide-based therapeutics and diagnostic probes with enhanced stability and bioactivity.
CAT: BRP-00545
CAS: 1621330-39-9
Molecular Formula: C68H103N2O10P
Molecular Weight: 1139.53
Purity: ≥97%
Appearance: Colorless to light yellow oily matter
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Storage: Store at -20 °C
InChIKey: CVFFLEDYEBZJDX-HSRHINSZSA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: N#CCCOP(OC(COCCOCCOCCOC=1C(=C(C=2OC(C)(CCC2C1C)CCCC(C)CCCC(C)CCCC(C)C)C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C
IUPAC Name: 1,1-bis(4-methoxyphenyl)-1-phenyl-14-(((R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl)oxy)-2,6,9,12-tetraoxatetradecan-4-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C68H103N2O10P/c1-50(2)22-18-23-53(7)24-19-25-54(8)26-20-38-67(12)39-37-64-57(11)65(55(9)56(10)66(64)79-67)76-47-46-74-43-42-73-44-45-75-48-63(80-81(78-41-21-40-69)70(51(3)4)52(5)6)49-77-68(58-27-16-15-17-28-58,59-29-33-61(71-13)34-30-59)60-31-35-62(72-14)36-32-60/h15-17,27-36,50-54,63H,18-26,37-39,41-49H2,1-14H3/t53-,54-,63?,67-,81?/m1/s1
Synonyms: 1-Dimethoxytrityloxy-3-O-[(9-DL-α-tocopheryl)-triethyleneglycol-1-yl]-glyceryl-2-O-[(2-cyanoethyl)-(N,N,-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[2-[2-[2-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]ethoxy]ethoxy]ethoxy]methyl]ethyl 2-cyanoethyl ester; 2-[Bis(4-methoxyphenyl)phenylmethoxy]-1-[[2-[2-[2-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]ethoxy]ethoxy]ethoxy]methyl]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; α-Tocopherol TEG phosphoramidite; Tocopherol TEG Phosphoramidite

Palmitate Phosphoramidite

Description: Palmitate Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce palmitic acid moieties into the oligonucleotide sequence. Palmitic acid is a saturated fatty acid commonly found in biological membranes and is known for its amphipathic properties. By attaching palmitic acid to oligonucleotides, researchers can modify the properties of the resulting conjugates, such as enhancing membrane permeability or promoting lipid bilayer interactions. This modification enables the development of oligonucleotide-based therapeutics, drug delivery systems, and molecular probes with improved cellular uptake and stability.
CAT: BRP-00546
CAS: 1772522-18-5
Molecular Formula: C31H62N3O3P
Molecular Weight: 555.82
Purity: ≥90% by HPLC
Appearance: White to off-white solid
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Storage: Store at -20 °C
InChIKey: BFUDAHSNZSPONN-UHFFFAOYSA-N
CanonicalSMILES: CCCCCCCCCCCCCCCC(=O)NCCCCCCOP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]hexadecanamide
InChI: InChI=1S/C31H62N3O3P/c1-6-7-8-9-10-11-12-13-14-15-16-17-20-24-31(35)33-26-21-18-19-22-27-36-38(37-28-23-25-32)34(29(2)3)30(4)5/h29-30H,6-24,26-28H2,1-5H3,(H,33,35)
Synonyms: Palmityl-6-aminohexyl [(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 6-[(1-oxohexadecyl)amino]hexyl ester; 2-Cyanoethyl 6-[(1-oxohexadecyl)amino]hexyl N,N-bis(1-methylethyl)phosphoramidite; Palmitic Aminohexanol Amidite; 2-cyanoethyl (6-palmitamidohexyl) diisopropylphosphoramidite; Palmitic Aminohexanol Phosphoramidite

Stearyl Phosphoramidite

Description: Stearyl Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a stearyl group (octadecyl chain) at the 5'-end of the oligonucleotide sequence. Stearyl groups are long-chain fatty acids that enhance the hydrophobicity and lipophilicity of the oligonucleotide, improving its ability to interact with lipid membranes. This modification is beneficial for developing oligonucleotide-based therapeutics and delivery systems, as it can enhance cellular uptake and stability. Stearyl-modified oligonucleotides are often used in gene silencing, antisense therapies, and other applications requiring efficient delivery and cellular internalization.
CAT: BRP-00547
CAS: 207273-84-5
Molecular Formula: C27H55N2O2P
Molecular Weight: 470.71
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Storage: Store at -20 °C
InChIKey: KZQNEBQNUQNMRG-UHFFFAOYSA-N
CanonicalSMILES: CCCCCCCCCCCCCCCCCCOP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: 3-[[di(propan-2-yl)amino]-octadecoxyphosphanyl]oxypropanenitrile
InChI: InChI=1S/C27H55N2O2P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-24-30-32(31-25-22-23-28)29(26(2)3)27(4)5/h26-27H,6-22,24-25H2,1-5H3
Synonyms: 1-Octadecanol CEP; C18-linker amidite; Octadecyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl octadecyl ester; 5'-Stearyl phosphoramidite

Asymmetric Doubler (Lev) Phosphoramidite

Description: Asymmetric Doubler (Lev) Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce an asymmetric doubler modification into the oligonucleotide sequence. This modification features a levulinyl (Lev) protecting group, which provides additional control during the synthesis process. The asymmetric doubler facilitates the incorporation of two nucleotides in a single coupling step, improving synthesis efficiency and allowing for the introduction of unique structural or functional properties. This reagent is valuable for creating complex oligonucleotide structures and is used in various applications, including the development of therapeutic oligonucleotides, advanced molecular probes, and functional nucleic acids for research and diagnostic purposes.
CAT: BRP-00548
CAS: 2195357-46-9
Molecular Formula: C48H67N4O10P
Molecular Weight: 891.04
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Storage: Store at -20 °C
InChIKey: QREZMNJRLYXRTD-UHFFFAOYSA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CNC(=O)CCCCOC(=O)CCC(=O)C)CNC(=O)CCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC
IUPAC Name: [5-[[3-[5-[bis(4-methoxyphenyl)-phenylmethoxy]pentanoylamino]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]amino]-5-oxopentyl] 4-oxopentanoate
InChI: InChI=1S/C48H67N4O10P/c1-36(2)52(37(3)4)63(61-33-15-30-49)62-44(34-50-45(54)18-11-13-31-59-47(56)29-20-38(5)53)35-51-46(55)19-12-14-32-60-48(39-16-9-8-10-17-39,40-21-25-42(57-6)26-22-40)41-23-27-43(58-7)28-24-41/h8-10,16-17,21-28,36-37,44H,11-15,18-20,29,31-35H2,1-7H3,(H,50,54)(H,51,55)
Synonyms: 1-[5-(4,4'-dimethoxytrityloxy)pentylamido]-3-[5-levulinyloxypentylamido]-propyl-2-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Pentanoic acid, 4-oxo-, 8-[[[5-[bis(4-methoxyphenyl)phenylmethoxy]-1-oxopentyl]amino]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-5-oxo-9-oxa-6,11-diaza-10-phosphatridec-1-yl ester; 8-[[[5-[Bis(4-methoxyphenyl)phenylmethoxy]-1-oxopentyl]amino]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-5-oxo-9-oxa-6,11-diaza-10-phosphatridec-1-yl 4-oxopentanoate

Universal-CE Phosphoramidite

Description: Universal-CE Phosphoramidite is a versatile reagent used in oligonucleotide synthesis. It is designed to be incorporated at any position within the oligonucleotide sequence, providing a universal solution for a variety of modifications. This phosphoramidite enables the attachment of different functional groups or linkers to the oligonucleotide, facilitating applications such as labeling, conjugation, and immobilization. Its flexibility makes it particularly useful in research and diagnostic applications where customization of the oligonucleotide sequence is required. The Universal-CE Phosphoramidite enhances the efficiency and adaptability of the oligonucleotide synthesis process, supporting the development of tailored nucleic acid-based tools and therapeutics.
CAT: BRP-00549
CAS: 730963-37-8
Molecular Formula: C23H36N3O8P
Molecular Weight: 513.52
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Storage: Store at -20 °C
InChIKey: CBZZWACFDATALS-LTPKXJDNNA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: N#CCCOP(OCCCN1C(=O)C2C3OC(C4OC(OC)(OC43)C)C2C1=O)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl (3-((2r,3aR,4R,4aR,7aS,8S,8aS)-2-methoxy-2-methyl-5,7-dioxooctahydro-6H-4,8-epoxy[1,3]dioxolo[4,5-f]isoindol-6-yl)propyl) diisopropylphosphoramidite
InChI: InChI=1/C23H36N3O8P/c1-13(2)26(14(3)4)35(30-11-7-9-24)31-12-8-10-25-21(27)15-16(22(25)28)18-20-19(17(15)32-18)33-23(5,29-6)34-20/h13-20H,7-8,10-12H2,1-6H3/t15-,16+,17-,18+,19-,20+,23+,35?
Synonyms: 3-[(3aR,4R,5R,6S,7S)-6-(4,4'-dimethoxytrityloxy)-5-acetoxy-1-,3-dioxooctahydro-1H-4,7-epoxyisoindol-2-yl]propyl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 3-[(2α,3aα,4β,4aα,7aα,8β,8aα)-octahydro-2-methoxy-2-methyl-5,7-dioxo-4,8-epoxy-6H-1,3-dioxolo[4,5-f]isoindol-6-yl]propyl ester

DMTr-2'-O-TBDMS-rA(Bz)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-TBDMS-rA(Bz)-3'-(L)-PSM-Phosphoramidite is a compound used in oligonucleotide synthesis. It protects adenine (rA) at the 5'-position with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it attaches a benzoyl (Bz) group to the adenine base and introduces a 3'-(L)-PSM modifier at the 3'-end. This compound enables precise synthesis of oligonucleotides with specific modifications for various applications.
CAT: BRP-00555
Molecular Formula: C56H63N6O10PSSi
Molecular Weight: 1071.27
Purity: ≥98%
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Storage: Store at -20 °C
InChIKey: JEWOWPFMMHAFMF-KDYSEBNISA-N
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C56H63N6O10PSSi/c1-55(2,3)75(6,7)72-50-49(71-73-62-33-17-24-45(62)47(70-73)35-74(64,65)44-22-15-10-16-23-44)46(69-54(50)61-37-59-48-51(57-36-58-52(48)61)60-53(63)38-18-11-8-12-19-38)34-68-56(39-20-13-9-14-21-39,40-25-29-42(66-4)30-26-40)41-27-31-43(67-5)32-28-41/h8-16,18-23,25-32,36-37,45-47,49-50,54H,17,24,33-35H2,1-7H3,(H,57,58,60,63)/t45-,46+,47+,49+,50+,54+,73+/m0/s1

DMTr-2'-O-TBDMS-rA(Bz)-3'-(D)-PSM-Phosphoramidite

Description: DMTr-2'-O-TBDMS-rA(Bz)-3'-(D)-PSM-Phosphoramidite is a chemical compound used in oligonucleotide synthesis. It protects adenine (rA) at the 5'-position with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it attaches a benzoyl (Bz) group to the adenine base. The 3'-(D)-PSM modifier introduces a functional group at the 3'-end of the oligonucleotide. This compound allows for controlled synthesis of customized oligonucleotides for various applications in molecular biology and biotechnology.
CAT: BRP-00556
Molecular Formula: C56H63N6O10PSSi
Molecular Weight: 1071.27
Purity: ≥98%
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InChIKey: JEWOWPFMMHAFMF-OPURRIEGSA-N
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((1R,3R,3aR)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C56H63N6O10PSSi/c1-55(2,3)75(6,7)72-50-49(71-73-62-33-17-24-45(62)47(70-73)35-74(64,65)44-22-15-10-16-23-44)46(69-54(50)61-37-59-48-51(57-36-58-52(48)61)60-53(63)38-18-11-8-12-19-38)34-68-56(39-20-13-9-14-21-39,40-25-29-42(66-4)30-26-40)41-27-31-43(67-5)32-28-41/h8-16,18-23,25-32,36-37,45-47,49-50,54H,17,24,33-35H2,1-7H3,(H,57,58,60,63)/t45-,46-,47+,49-,50-,54-,73+/m1/s1

DMTr-2'-O-TBDMS-5-Cl-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-Cl-rU-3'-CE-Phosphoramidite is a chemical compound used in oligonucleotide synthesis. It protects the 5'-hydroxyl group with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it incorporates 5-chloro-uridine as a modified nucleoside. The 3'-CE phosphoramidite facilitates nucleotide addition during synthesis. This compound allows for the controlled synthesis of oligonucleotides with specific modifications, important for various applications in molecular biology and biotechnology.
CAT: BRP-00558
Molecular Formula: C45H60ClN4O9PSi
Molecular Weight: 895.50
Purity: ≥98%
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InChIKey: RRACSVOLQAOFCZ-IPXQPGKOSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)Cl)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-chloro-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C45H60ClN4O9PSi/c1-30(2)50(31(3)4)60(56-27-15-26-47)58-39-38(57-42(40(39)59-61(10,11)44(5,6)7)49-28-37(46)41(51)48-43(49)52)29-55-45(32-16-13-12-14-17-32,33-18-22-35(53-8)23-19-33)34-20-24-36(54-9)25-21-34/h12-14,16-25,28,30-31,38-40,42H,15,27,29H2,1-11H3,(H,48,51,52)/t38-,39-,40-,42-,60?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-chloro-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-TBDMS-5-F-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-F-rU-3'-CE-Phosphoramidite is a chemical compound utilized in oligonucleotide synthesis. It safeguards the 5'-hydroxyl group with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it incorporates 5-fluoro-uridine as a modified nucleoside. The 3'-CE phosphoramidite facilitates nucleotide addition during synthesis. This compound enables precise control over oligonucleotide synthesis, essential for various applications in molecular biology and biotechnology.
CAT: BRP-00559
CAS: 173241-78-6
Molecular Formula: C45H60FN4O9PSi
Molecular Weight: 879.05
Purity: ≥98%
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InChIKey: MKGOHNKOHNRJLF-IPXQPGKOSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)F)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C45H60FN4O9PSi/c1-30(2)50(31(3)4)60(56-27-15-26-47)58-39-38(57-42(40(39)59-61(10,11)44(5,6)7)49-28-37(46)41(51)48-43(49)52)29-55-45(32-16-13-12-14-17-32,33-18-22-35(53-8)23-19-33)34-20-24-36(54-9)25-21-34/h12-14,16-25,28,30-31,38-40,42H,15,27,29H2,1-11H3,(H,48,51,52)/t38-,39-,40-,42-,60?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-fluoro-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5-Fluoro Uridine CED phosphoramidite

DMTr-2'-O-TBDMS-5-OMe-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-OMe-rU-3'-CE-Phosphoramidite is employed in oligonucleotide synthesis and features a TBDMS (tert-butyldimethylsilyl) group at the 2'-O position, and a methoxy (OMe) group on the uracil (rU) nucleoside. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is used to introduce modified uracil residues with increased stability and altered base pairing properties into nucleic acid sequences, suitable for various research applications including RNA structural studies, aptamer development, and gene regulation research.
CAT: BRP-00560
Molecular Formula: C46H63N4O10PSi
Molecular Weight: 891.09
Purity: ≥98%
Appearance: White, off-white to faint yellow powder
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InChIKey: OWTUZLAYUDYRNE-ACYYXZCMSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)OC)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-methoxy-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C46H63N4O10PSi/c1-31(2)50(32(3)4)61(57-28-16-27-47)59-40-39(58-43(41(40)60-62(11,12)45(5,6)7)49-29-38(55-10)42(51)48-44(49)52)30-56-46(33-17-14-13-15-18-33,34-19-23-36(53-8)24-20-34)35-21-25-37(54-9)26-22-35/h13-15,17-26,29,31-32,39-41,43H,16,28,30H2,1-12H3,(H,48,51,52)/t39-,40-,41-,43-,61?/m1/s1
Synonyms: 5'-O-DMTr-2'-O-TBDMS-5-methoxyuridine-3'-(cyanoethyl-N,N-diisopropyl)phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methoxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMT-2'-O-TBDMS-5-OMe-Ur Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-5-O-methyl-Uridine 3'-cyanoethyl Phosphoramidite

5'-POM-(E)-vinyl phosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite is employed to introduce modified cytosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00561
Molecular Formula: C39H57N5O13P2
Molecular Weight: 865.85
Purity: ≥98%
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InChIKey: JCWBJBRNLLVLQY-ZUZGDNAQSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OC)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C
IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C39H57N5O13P2/c1-26(2)44(27(3)4)58(53-22-15-20-40)57-31-29(19-23-59(49,54-24-51-35(46)38(5,6)7)55-25-52-36(47)39(8,9)10)56-34(32(31)50-11)43-21-18-30(42-37(43)48)41-33(45)28-16-13-12-14-17-28/h12-14,16-19,21,23,26-27,29,31-32,34H,15,22,24-25H2,1-11H3,(H,41,42,45,48)/b23-19+/t29-,31-,32-,34-,58?/m1/s1

5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite is employed to introduce modified guanine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA structural studies, aptamer development, and gene regulation research.
CAT: BRP-00562
Molecular Formula: C37H59N7O13P2
Molecular Weight: 871.86
Purity: ≥98%
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InChIKey: BVJBAQGYDLYVPP-OGBCVAHGSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OC)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C
IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C37H59N7O13P2/c1-22(2)30(45)41-35-40-29-26(31(46)42-35)39-19-43(29)32-28(50-13)27(57-58(53-17-14-16-38)44(23(3)4)24(5)6)25(56-32)15-18-59(49,54-20-51-33(47)36(7,8)9)55-21-52-34(48)37(10,11)12/h15,18-19,22-25,27-28,32H,14,17,20-21H2,1-13H3,(H2,40,41,42,45,46)/b18-15+/t25-,27-,28-,32-,58?/m1/s1
Synonyms: 5'(E)-VP-2'-OMe-G(ibu)-CE-Phoshoramidite; 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite; 5'-(E)-VP-2'-OMe-G(iBu)-CE-Phoshoramidite

5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.
CAT: BRP-00563
Molecular Formula: C43H62N6O13P2
Molecular Weight: 932.95
Purity: ≥98%
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InChIKey: RKTQEWDKWSBILL-UQDZCBPASA-N
IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-4-methoxy-5-(6-(3-(3-methoxy-3-oxopropyl)phenyl)-9H-purin-9-yl)tetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C43H62N6O13P2/c1-28(2)49(29(3)4)63(58-21-14-20-44)62-36-32(19-22-64(53,59-26-56-40(51)42(5,6)7)60-27-57-41(52)43(8,9)10)61-39(37(36)55-12)48-25-47-35-34(45-24-46-38(35)48)31-16-13-15-30(23-31)17-18-33(50)54-11/h13,15-16,19,22-25,28-29,32,36-37,39H,14,17-18,21,26-27H2,1-12H3/b22-19+/t32-,36-,37-,39-,63?/m1/s1

DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-Phosphoramidite is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00564
CAS: 2379296-27-0
Molecular Formula: C51H51N6O10PS
Molecular Weight: 971.03
Purity: ≥98%
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InChIKey: GAVWOPVBQOSPKA-GPNGAECYSA-N
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OC)C=%10C=CC=CC%10
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1R,3R,3aR)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C51H51N6O10PS/c1-61-38-25-21-36(22-26-38)51(35-16-9-5-10-17-35,37-23-27-39(62-2)28-24-37)64-30-42-45(67-68-57-29-13-20-41(57)43(66-68)31-69(59,60)40-18-11-6-12-19-40)46(63-3)50(65-42)56-33-54-44-47(52-32-53-48(44)56)55-49(58)34-14-7-4-8-15-34/h4-12,14-19,21-28,32-33,41-43,45-46,50H,13,20,29-31H2,1-3H3,(H,52,53,55,58)/t41-,42-,43+,45-,46-,50-,68+/m1/s1
Synonyms: (D)-PSM-MA-RP; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-3'-O-[(1R,3R,3aR)-tetrahydro-3-[(phenylsulfonyl)methyl]-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]-

DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00565
CAS: 2379296-17-8
Molecular Formula: C51H51N6O10PS
Molecular Weight: 971.03
Purity: ≥98%
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InChIKey: GAVWOPVBQOSPKA-UKMMDQOKSA-N
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OC)C=%10C=CC=CC%10
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C51H51N6O10PS/c1-61-38-25-21-36(22-26-38)51(35-16-9-5-10-17-35,37-23-27-39(62-2)28-24-37)64-30-42-45(67-68-57-29-13-20-41(57)43(66-68)31-69(59,60)40-18-11-6-12-19-40)46(63-3)50(65-42)56-33-54-44-47(52-32-53-48(44)56)55-49(58)34-14-7-4-8-15-34/h4-12,14-19,21-28,32-33,41-43,45-46,50H,13,20,29-31H2,1-3H3,(H,52,53,55,58)/t41-,42+,43+,45+,46+,50+,68+/m0/s1
Synonyms: (L)-PSM-MA-RP; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-3'-O-[(1S,3S,3aS)-tetrahydro-3-[(phenylsulfonyl)methyl]-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]-

DMTr-2'-O-Me-rG(iBu)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-Me-rG(iBu)-3'-(L)-PSM-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.
CAT: BRP-00566
Molecular Formula: C48H53N6O11PS
Molecular Weight: 953.02
Purity: ≥98%
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InChIKey: QCPFOYJTUFIVGR-JADAPZILSA-N
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OC
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxy-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
InChI: InChI=1S/C48H53N6O11PS/c1-30(2)44(55)51-47-50-43-40(45(56)52-47)49-29-53(43)46-42(61-5)41(65-66-54-26-12-17-37(54)39(64-66)28-67(57,58)36-15-10-7-11-16-36)38(63-46)27-62-48(31-13-8-6-9-14-31,32-18-22-34(59-3)23-19-32)33-20-24-35(60-4)25-21-33/h6-11,13-16,18-25,29-30,37-39,41-42,46H,12,17,26-28H2,1-5H3,(H2,50,51,52,55,56)/t37-,38+,39+,41+,42+,46+,66+/m0/s1
* Only for research. Not suitable for any diagnostic or therapeutic use.

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