What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

5'-O-DMT-N4-Acetyl-5-Methy-2'-O-(2-methoxyethyl)cytidine 3'-CE phosphoramidite

Description: 5'-O-DMT-N4-Acetyl-5-Methyl-2'-O-(2-methoxyethyl)cytidine 3'-CE phosphoramidite is a modified nucleotide phosphoramidite used in oligonucleotide synthesis. It contains a cytidine nucleotide with a dimethoxytrityl (DMT) protecting group on the 5'-hydroxyl group, an acetyl (Ac) group on the N4 position of the cytosine base, and a methyl group on the 5-position of the cytosine base. Additionally, a 2-methoxyethyl group is attached to the 2'-hydroxyl group of cytidine. This phosphoramidite is employed in the synthesis of modified oligonucleotides for various research and diagnostic applications.

CAT: BRP-00736

Molecular Formula: C45H58N5O10P

Molecular Weight: 859.96

Purity: >98%

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: RLGAWJOBUUSYCH-ACYYXZCMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-methoxyethoxy)oxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C45H58N5O10P/c1-30(2)50(31(3)4)61(58-25-13-24-46)60-40-39(59-43(41(40)56-27-26-53-7)49-28-32(5)42(47-33(6)51)48-44(49)52)29-57-45(34-14-11-10-12-15-34,35-16-20-37(54-8)21-17-35)36-18-22-38(55-9)23-19-36/h10-12,14-23,28,30-31,39-41,43H,13,25-27,29H2,1-9H3,(H,47,48,51,52)/t39-,40-,41-,43-,61?/m1/s1

Synonyms: 5-Me-DMT-2'-O-MOE-C(Ac)-CE-Phosphoramidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N4-acetyl-2'-O-methoxyethyl-5-O-dimethoxytrityl-5-methylcytidine-3'-phosphoramidite; N4-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methylcytidine-3'-amidite; 2'-MOE MeC(Ac) amidite; (2R,3R,4R,5R)-5-(4-acetamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; N4-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl phosphoramidite

DMT-PEG Phosphoramidite 20

Description: DMT-PEG Phosphoramidite 20 is a phosphoramidite compound utilized in oligonucleotide synthesis. It contains a DMT (dimethoxytrityl) protective group and a polyethylene glycol (PEG) linker, allowing for the introduction of PEG moieties into oligonucleotide sequences, which can confer various properties such as enhanced solubility or altered binding affinity.

CAT: BRP-00737

CAS: 165682-45-1

Molecular Formula: C44H65N2O11P

Molecular Weight: 828.98

Purity: >98%

Appearance: Colorless to light yellow oily matter

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Storage: Store at -20 °C

InChIKey: ZEMYDSDLDZPUBS-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCOCCOCCOCCOCCOCCOCCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 1,1-bis(4-methoxyphenyl)-1-phenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H65N2O11P/c1-37(2)46(38(3)4)58(56-22-10-21-45)57-36-34-54-32-30-52-28-26-50-24-23-49-25-27-51-29-31-53-33-35-55-44(39-11-8-7-9-12-39,40-13-17-42(47-5)18-14-40)41-15-19-43(48-6)20-16-41/h7-9,11-20,37-38H,10,22-36H2,1-6H3

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 22,22-bis(4-methoxyphenyl)-22-phenyl-3,6,9,12,15,18,21-heptaoxadocos-1-yl 2-cyanoethyl ester; DMTr PEG7 amidite; Spacer Phosphoramidite 20; 20-O-Dimethoxytritylheptaethyleneglycol, 1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

PMO C (Ac)

Description: PMO C (Ac) is a novel biomedical compound. With its unique molecular structure, it exhibits potential as a targeted therapeutic agent for treating various diseases.

CAT: BRP-00738

Molecular Formula: C32H35ClN5O5P

Molecular Weight: 636.09

Purity: >98%

Appearance: White to off-white powder

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InChIKey: STADUQUAHZZNDG-REKZWXCCSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2CN(CC(O2)COP(=O)(N(C)C)Cl)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

IUPAC Name: N-[1-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C32H35ClN5O5P/c1-24(39)34-29-19-20-38(31(40)35-29)30-22-37(21-28(43-30)23-42-44(33,41)36(2)3)32(25-13-7-4-8-14-25,26-15-9-5-10-16-26)27-17-11-6-12-18-27/h4-20,28,30H,21-23H2,1-3H3,(H,34,35,39,40)/t28-,30+,44?/m0/s1

Synonyms: ((2S,6R)-6-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate; [(2S,6R)-6-[4-(Acetylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate

Related CAS: 2077093-68-4 (S-isomer) ; 2077093-70-8 (R-isomer)

PMO A (Ac)

Description: PMO A (Ac) is a novel biomedical compound. With its unique molecular structure, it exhibits potential as a targeted therapeutic agent for treating various diseases.

CAT: BRP-00739

Molecular Formula: C33H35ClN7O4P

Molecular Weight: 660.11

Purity: >98%

Appearance: White to off-white powder

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InChIKey: JHJWWJWGIULSQK-MLNKQRNVSA-N

CanonicalSMILES: CC(=O)NC1=C2C(=NC=N1)N(C=N2)C3CN(CC(O3)COP(=O)(N(C)C)Cl)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

IUPAC Name: N-[9-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]purin-6-yl]acetamide

InChI: InChI=1S/C33H35ClN7O4P/c1-24(42)38-31-30-32(36-22-35-31)41(23-37-30)29-20-40(19-28(45-29)21-44-46(34,43)39(2)3)33(25-13-7-4-8-14-25,26-15-9-5-10-16-26)27-17-11-6-12-18-27/h4-18,22-23,28-29H,19-21H2,1-3H3,(H,35,36,38,42)/t28-,29+,46?/m0/s1

Synonyms: ((2S,6R)-6-(6-acetamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate; [(2S,6R)-6-[6-(acetamido)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate

Reverse Abasic Phosphoramidite

Description: Reverse Abasic Phosphoramidite is a specialized compound used in oligonucleotide synthesis. It allows for the controlled introduction of abasic sites, which are sites lacking a nucleobase, into oligonucleotide sequences. These abasic sites serve as versatile molecular tools for various applications in molecular biology, including studying nucleic acid structure, elucidating enzyme kinetics, and investigating nucleic acid-protein interactions.

CAT: BRP-00740

CAS: 401813-16-9

Molecular Formula: C35H45N2O6P

Molecular Weight: 620.73

Purity: >98%

Appearance: White to faint yellow powder

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Storage: Store at -20 °C

InChIKey: WPNQXLQBMSUHFX-JUWSMZLESA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1C(CCO1)OC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC

IUPAC Name: 3-[[(2R,3S)-3-[bis(4-methoxyphenyl)-phenylmethoxy]oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C35H45N2O6P/c1-26(2)37(27(3)4)44(41-23-10-22-36)42-25-34-33(21-24-40-34)43-35(28-11-8-7-9-12-28,29-13-17-31(38-5)18-14-29)30-15-19-32(39-6)20-16-30/h7-9,11-20,26-27,33-34H,10,21,23-25H2,1-6H3/t33-,34+,44?/m0/s1

Synonyms: D-erythro-Pentitol, 1,4-anhydro-3-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-, 2-cyanoethyl bis(1-methylethyl)phosphoramidite; 3'-O-(4,4'-dimethoxytrityl)-1',2'-Dideoxy D-ribose-5'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; ((2R,3S)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

N4-Ac-7'-OH-N-trityl Morpholino cytosine

Description: N4-Ac-7'-OH-N-trityl Morpholino cytosine may have various applications in medicinal chemistry, particularly in the development of pharmaceuticals or as a building block in organic synthesis. Its specific structure suggests potential biological activity or affinity for certain receptors or enzymes, making it of interest in drug discovery or chemical biology research.

CAT: BRP-00741

Molecular Formula: C30H30N4O4

Molecular Weight: 510.59

Purity: >98%

Appearance: White to yellow powder

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Density: 1.25±0.1 g/cm3

InChIKey: LUTKQLULCNFMMH-XTEPFMGCSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2CN(CC(O2)CO)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

IUPAC Name: N-[1-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C30H30N4O4/c1-22(36)31-27-17-18-34(29(37)32-27)28-20-33(19-26(21-35)38-28)30(23-11-5-2-6-12-23,24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-18,26,28,35H,19-21H2,1H3,(H,31,32,36,37)/t26-,28+/m0/s1

Synonyms: N-[1,2-Dihydro-1-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-2-oxo-4-pyrimidinyl]acetamide; N-(1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

6-Ac-7'-OH-N-trityl morpholino adenosine

Description: 6-Ac-7'-OH-N-trityl morpholino adenosine may have applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting purine receptors or enzymes involved in purine metabolism. Its specific structure suggests potential biological activity, making it of interest in drug discovery or chemical biology research.

CAT: BRP-00742

Molecular Formula: C31H30N6O3

Molecular Weight: 534.62

Purity: >98%

Appearance: White to yellow powder

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InChIKey: URLFNHWSISCXNB-RRPNLBNLSA-N

CanonicalSMILES: CC(=O)NC1=C2C(=NC=N1)N(C=N2)C3CN(CC(O3)CO)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

IUPAC Name: N-[9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]purin-6-yl]acetamide

InChI: InChI=1S/C31H30N6O3/c1-22(39)35-29-28-30(33-20-32-29)37(21-34-28)27-18-36(17-26(19-38)40-27)31(23-11-5-2-6-12-23,24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-16,20-21,26-27,38H,17-19H2,1H3,(H,32,33,35,39)/t26-,27+/m0/s1

Synonyms: N-(9-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-9H-purin-6-yl)acetamide; N-[9-[(2R,6S)-6-(Hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-9H-purin-6-yl]acetamide; N6-Ac-7'-OH-N-trityl morpholino adenosine

GalNAc-L96 Phosphoramidite

Description: GalNAc-L96 Phosphoramidite is a specialized chemical compound used in oligonucleotide synthesis, particularly in the synthesis of RNA molecules with specific modifications. It contains a GalNAc (N-acetylgalactosamine) group attached to the 5' position of a nucleoside via a linker, allowing for the site-specific incorporation of GalNAc into RNA sequences. This modification mimics natural post-transcriptional modifications found in RNA molecules, such as glycosylation, and can alter the properties and functions of RNA. GalNAc-L96 Phosphoramidite is valuable in research areas such as RNA therapeutics and functional genomics, where modified RNA molecules are used for targeted gene regulation or diagnostic purposes.

CAT: BRP-00743

Molecular Formula: C126H192N13O43P

Molecular Weight: 2607.94

Purity: 98%

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Storage: Store at -20 °C

InChIKey: GJNRYTJOWJMTKY-LXXTXPAYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(N(C1)C(=O)CCCCCCCCCCC(=O)NC(COCCC(=O)NCCCNC(=O)CCCCOC2C(C(C(C(O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)(COCCC(=O)NCCCNC(=O)CCCCOC3C(C(C(C(O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)COCCC(=O)NCCCNC(=O)CCCCOC4C(C(C(C(O4)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: [(2R,3R,4R,5R,6R)-5-acetamido-6-[5-[3-[3-[3-[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]-2-[[12-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypyrrolidin-1-yl]-12-oxododecanoyl]amino]propoxy]propanoylamino]propylamino]-5-oxopentoxy]-3,4-diacetyloxyoxan-2-yl]methyl acetate

InChI: InChI=1S/C126H192N13O43P/c1-81(2)139(82(3)4)183(172-68-36-58-127)182-101-72-98(74-171-126(95-40-26-25-27-41-95,96-47-51-99(160-17)52-48-96)97-49-53-100(161-18)54-50-97)138(73-101)112(159)46-29-24-22-20-19-21-23-28-45-111(158)137-125(78-162-69-55-108(155)131-62-37-59-128-105(152)42-30-33-65-165-122-113(134-83(5)140)119(176-92(14)149)116(173-89(11)146)102(179-122)75-168-86(8)143,79-163-70-56-109(156)132-63-38-60-129-106(153)43-31-34-66-166-123-114(135-84(6)141)120(177-93(15)150)117(174-90(12)147)103(180-123)76-169-87(9)144)80-164-71-57-110(157)133-64-39-61-130-107(154)44-32-35-67-167-124-115(136-85(7)142)121(178-94(16)151)118(175-91(13)148)104(181-124)77-170-88(10)145/h25-27,40-41,47-54,81-82,98,101-104,113-124H,19-24,28-39,42-46,55-57,59-80H2,1-18H3,(H,128,152)(H,129,153)(H,130,154)(H,131,155)(H,132,156)(H,133,157)(H,134,140)(H,135,141)(H,136,142)(H,137,158)/t98-,101+,102+,103+,104+,113+,114+,115+,116-,117-,118-,119+,120+,121+,122+,123+,124+,183?/m0/s1

Synonyms: GalNAc Phosphoramidite; GalNac-L96

Unylinker

CAT: BRP-00754

CAS: 852684-08-3

Molecular Formula: C39H35NO10 (free acid)

Molecular Weight: 677.71 (free acid)

Purity: >98%

Appearance: White to yellow powder

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Density: 1.41±0.1 g/cm3

Boiling Point: 871.5±65.0 °C at 760 mmHg

InChIKey: KPROLRFVRRGFBD-VXPJIIKRNA-N

CanonicalSMILES: O=C(O)CCC(=O)OC1C(OC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C5OC1C6C(=O)N(C(=O)C56)C=7C=CC=CC7

IUPAC Name: rel-4-(((3aR,4R,5R,6S,7S,7aS)-6-(bis(4-methoxyphenyl)(phenyl)methoxy)-1,3-dioxo-2-phenyloctahydro-1H-4,7-epoxyisoindol-5-yl)oxy)-4-oxobutanoic acid

InChI: InChI=1/C39H35NO10/c1-46-27-17-13-24(14-18-27)39(23-9-5-3-6-10-23,25-15-19-28(47-2)20-16-25)50-36-34-32-31(33(49-34)35(36)48-30(43)22-21-29(41)42)37(44)40(38(32)45)26-11-7-4-8-12-26/h3-20,31-36H,21-22H2,1-2H3,(H,41,42)/t31-,32+,33-,34+,35-,36+/s2

Synonyms: Butanedioic acid, 1-[(3aR,4R,5R,6S,7S,7aS)-6-[bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] ester, rel-; Butanedioic acid, mono[(3aR,4R,5R,6S,7S,7aS)-6-[bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] ester, rel-; rel-1-[(3aR,4R,5R,6S,7S,7aS)-6-[Bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] butanedioate; UnyLinker

Related CAS: 852684-09-4 (TEA salt)

Unylinker TEA salt

Description: Unylinker is a versatile linker molecule used in oligonucleotide synthesis and conjugation chemistry. It provides a stable yet cleavable bond between biomolecules or solid supports, allowing for controlled release or attachment. In its TEA (triethylammonium) salt form, it enhances solubility and stability, facilitating its application in various biochemical assays and protocols.

CAT: BRP-00755

CAS: 852684-09-4

Molecular Formula: C39H35NO10.C6H15N

Molecular Weight: 778.89

Purity: >98%

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InChIKey: UOLREVIUECQZSG-LEPPYWKBNA-N

CanonicalSMILES: O=C(O)CCC(=O)OC1C(OC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C5OC1C6C(=O)N(C(=O)C56)C=7C=CC=CC7.N(CC)(CC)CC

IUPAC Name: rel-4-(((3aR,4R,5R,6S,7S,7aS)-6-(bis(4-methoxyphenyl)(phenyl)methoxy)-1,3-dioxo-2-phenyloctahydro-1H-4,7-epoxyisoindol-5-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1/C39H35NO10.C6H15N/c1-46-27-17-13-24(14-18-27)39(23-9-5-3-6-10-23,25-15-19-28(47-2)20-16-25)50-36-34-32-31(33(49-34)35(36)48-30(43)22-21-29(41)42)37(44)40(38(32)45)26-11-7-4-8-12-26;1-4-7(5-2)6-3/h3-20,31-36H,21-22H2,1-2H3,(H,41,42);4-6H2,1-3H3/t31-,32+,33-,34+,35-,36+;/s2

Synonyms: Butanedioic acid, 1-[(3aR,4R,5R,6S,7S,7aS)-6-[bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] ester, rel-, compd. with N,N-diethylethanamine (1:1); Butanedioic acid, mono[(3aR,4R,5R,6S,7S,7aS)-6-[bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] ester, rel-, compd. with N,N-diethylethanamine (1:1); UnyLinker triethylamine salt

Related CAS: 852684-08-3 (free base)

O(6)-NPE-Morpholino G(iBu) succinate, TEA salt

Description: O(6)-NPE-Morpholino G(iBu) succinate, TEA salt imparts unique properties suitable for applications such as antisense oligonucleotide synthesis and nucleic acid-based therapeutics.

CAT: BRP-00756

Molecular Formula: C45H45N7O9 (free acid)

Molecular Weight: 827.90 (free acid)

Purity: >98%

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-(((2S,6R)-6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 4-((6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)-4-oxobutanoic acid, triethylamine salt

Morpholino C(Bz) succinate, TEA salt

Description: Morpholino C(Bz) succinate, TEA salt confers stability and controlled reactivity during oligonucleotide assembly, making them valuable tools in nucleic acid research and therapeutic development.

CAT: BRP-00757

Molecular Formula: C39H36N4O7 (free acid)

Molecular Weight: 672.74 (free acid)

Purity: >98%

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[[(2S,6R)-6-(4-benzamido-2-oxopyrimidin-1-yl)-4-tritylmorpholin-2-yl]methoxy]-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: Butanedioic acid, 1-[[(2S,6R)-6-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl] ester triethylamine salt; 4-[[(2S,6R)-6-(4-Benzamide-2-oxopyrimidine-1(2H)-yl)-4-tritylmorpholine-2-yl]methoxy]-4-oxobutyric acid triethylamine salt; 4-[[(2S,6R)-6-(4-Benzamido-2-oxopyrimidin-1-yl)-4-tritylmorpholin-2-yl]methoxy]-4-oxobutanoic acid triethylamine salt; 1-[[(2S,6R)-6-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl] butanedioate triethylamine salt

Related CAS: 1362664-31-0 (free base)

Morpholino A(Bz) succinate, TEA salt

Description: Morpholino A(Bz) succinate, TEA salt confers stability and controlled reactivity during oligonucleotide assembly, making them valuable tools in nucleic acid research and therapeutic development.

CAT: BRP-00758

Molecular Formula: C40H36N6O6 (free acid)

Molecular Weight: 696.76 (free acid)

Purity: >98%

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[[(2S,6R)-6-(6-benzamidopurin-9-yl)-4-tritylmorpholin-2-yl]methoxy]-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 4-(((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)-4-oxobutanoic acid triethylamine salt; 1-[[(2S,6R)-6-[6-(Benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl] butanedioate triethylamine salt; Butanedioic acid, 1-[[(2S,6R)-6-[6-(benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl] ester triethylamine salt; 4-((6-(6-benzamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)-4-oxobutanoic acid, triethylamine salt

Related CAS: 1446206-67-2 (free base)

N-Trityl-N4-benzoyl-morpholino-C-7'-O-phosphoramidite

Description: Morpholino nucleoside phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives

CAT: BRP-00762

CAS: 2434794-97-3

Molecular Formula: C44H49N6O5P

Molecular Weight: 772.87

Purity: ≥97% by HPLC

Appearance: White to off-white foam solid

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Storage: Store at -20 °C, under inert atmosphere

InChIKey: BUAVHKSBQVLXPP-SKSUEDBOSA-N

Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1CN(CC(O1)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

IUPAC Name: N-[1-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C44H49N6O5P/c1-33(2)50(34(3)4)56(53-29-17-27-45)54-32-39-30-48(31-41(55-39)49-28-26-40(47-43(49)52)46-42(51)35-18-9-5-10-19-35)44(36-20-11-6-12-21-36,37-22-13-7-14-23-37)38-24-15-8-16-25-38/h5-16,18-26,28,33-34,39,41H,17,29-32H2,1-4H3,(H,46,47,51,52)/t39-,41+,56?/m0/s1

Synonyms: N-Trityl-N4-benzoyl-morpholino-C-5'-O-phosphoramidite; ((2S,6R)-6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

5'-O-DMTr-2'-O-methyl-N6-methyl adenosine 3'-CED phosphoramidite

Description: Phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives.

CAT: BRP-00763

CAS: 2348385-04-4

Molecular Formula: C42H52N7O7P

Molecular Weight: 797.88

Purity: ≥97% by HPLC

Appearance: White to off-white foam solid

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Storage: Store at -20 °C, under inert atmosphere

InChIKey: XXRTXDUOPCNYDH-DJADKNTFSA-N

Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H52N7O7P/c1-28(2)49(29(3)4)57(54-24-12-23-43)56-37-35(55-41(38(37)52-8)48-27-47-36-39(44-5)45-26-46-40(36)48)25-53-42(30-13-10-9-11-14-30,31-15-19-33(50-6)20-16-31)32-17-21-34(51-7)22-18-32/h9-11,13-22,26-29,35,37-38,41H,12,24-25H2,1-8H3,(H,44,45,46)/t35-,37-,38-,41-,57?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite; 5'-O-DMTr-2'-O-methyl-N6-methyladenosine-3'-phosphoramidite

N-Trityl-N2-isobutyryl-morpholino-G-7'-O-phosphoramidite

Description: Morpholino nucleoside phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives.

CAT: BRP-00764

CAS: 2434795-03-4

Molecular Formula: C42H51N8O5P

Molecular Weight: 778.88

Purity: ≥97% by HPLC

Appearance: White to off-white foam solid

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Storage: Store at -20 °C, under inert atmosphere

InChIKey: FRWLFVXCJRIGKK-AUOFHDIISA-N

Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3CN(CC(O3)COP(N(C(C)C)C(C)C)OCCC#N)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

IUPAC Name: N-[9-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C42H51N8O5P/c1-29(2)39(51)46-41-45-38-37(40(52)47-41)44-28-49(38)36-26-48(25-35(55-36)27-54-56(53-24-16-23-43)50(30(3)4)31(5)6)42(32-17-10-7-11-18-32,33-19-12-8-13-20-33)34-21-14-9-15-22-34/h7-15,17-22,28-31,35-36H,16,24-27H2,1-6H3,(H2,45,46,47,51,52)/t35-,36+,56?/m0/s1

Synonyms: N-Trityl-N2-isobutyryl-morpholino-G-5'-O-phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl) inosine 3'-CED phosphoramidite

Description: Phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives.

CAT: BRP-00765

Molecular Formula: C43H53N6O9P

Molecular Weight: 828.89

Purity: ≥97% by HPLC

Appearance: White to off-white foam solid

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Storage: Store at -20 °C, under inert atmosphere

InChIKey: FSSPCCHOIYMGBP-NFQMNAKDSA-N

Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-(6-oxo-1H-purin-9-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C43H53N6O9P/c1-29(2)49(30(3)4)59(56-23-11-22-44)58-38-36(57-42(39(38)54-25-24-51-5)48-28-47-37-40(48)45-27-46-41(37)50)26-55-43(31-12-9-8-10-13-31,32-14-18-34(52-6)19-15-32)33-16-20-35(53-7)21-17-33/h8-10,12-21,27-30,36,38-39,42H,11,23-26H2,1-7H3,(H,45,46,50)/t36-,38-,39-,42-,59?/m1/s1

Synonyms: DMTr-MOE-Inosine-3-CED-phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-MOE I amidite

N-Trityl-N6-benzoyl-morpholino-A(Bz)-7'-O-phosphoramidite

Description: Morpholino nucleoside phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives.

CAT: BRP-00766

CAS: 2434795-08-9

Molecular Formula: C45H49N8O4P

Molecular Weight: 796.90

Purity: ≥97% by HPLC

Appearance: White to off-white foam solid

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Storage: Store at -20 °C, under inert atmosphere

InChIKey: PKBMTUUGKIQWLB-SJMRETRVSA-N

Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1CN(CC(O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

IUPAC Name: N-[9-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C45H49N8O4P/c1-33(2)53(34(3)4)58(55-27-17-26-46)56-30-39-28-51(45(36-20-11-6-12-21-36,37-22-13-7-14-23-37)38-24-15-8-16-25-38)29-40(57-39)52-32-49-41-42(47-31-48-43(41)52)50-44(54)35-18-9-5-10-19-35/h5-16,18-25,31-34,39-40H,17,27-30H2,1-4H3,(H,47,48,50,54)/t39-,40+,58?/m0/s1

Synonyms: N-Trityl-N6-benzoyl-morpholino-A-5'-O-phosphoramidite; N-Trityl-N6-benzoyl-morpholino-A-7'-O-phosphoramidite; ((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

Lipid Phosphoramidite

Description: Lipid Phosphoramidite is a phosphoramidite derivative used in solid-phase synthesis of lipid-modified oligonucleotides. It contains a lipid moiety attached to a phosphoramidite backbone, facilitating the conjugation of oligonucleotides with lipids for applications such as drug delivery and gene silencing.

CAT: BRP-00771

CAS: 207273-85-6

Molecular Formula: C48H95N4O4P

Molecular Weight: 823.27

Purity: ≥95%

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InChIKey: GXAMBDAWMKUULA-UHFFFAOYSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCCC(=O)NCC(CNC(=O)CCCCCCCCCCCCCCCCC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(octadecanoylamino)propyl]octadecanamide

InChI: InChI=1S/C48H95N4O4P/c1-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-47(53)50-42-46(56-57(55-41-37-40-49)52(44(3)4)45(5)6)43-51-48(54)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-2/h44-46H,7-39,41-43H2,1-6H3,(H,50,53)(H,51,54)

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl ester; 2-cyanoethyl (1,3-distearamidopropan-2-yl) diisopropylphosphoramidite; 2-Cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl ester

Biotin (BB) CED phosphoramidite

Description: Biotin (BB) CED phosphoramidite is a phosphoramidite derivative used for the synthesis of biotinylated oligonucleotides. It contains a biotin moiety attached to a phosphoramidite backbone, enabling the specific labeling and purification of nucleic acids using biotin-streptavidin affinity methods.

CAT: BRP-00772

Molecular Formula: C57H76N5O9PS

Molecular Weight: 1038.28

Purity: ≥97% by HPLC

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: YMYNFOUBKWAXFH-YRZSEFLFSA-N

IUPAC Name: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(3-(5-((3aS,4S,6aR)-1-(4-(tert-butyl)benzoyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)propoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H76N5O9PS/c1-40(2)62(41(3)4)72(70-36-15-33-58)71-49(38-69-57(44-17-11-10-12-18-44,45-25-29-47(66-8)30-26-45)46-27-31-48(67-9)32-28-46)37-68-35-16-34-59-52(63)20-14-13-19-51-53-50(39-73-51)61(55(65)60-53)54(64)42-21-23-43(24-22-42)56(5,6)7/h10-12,17-18,21-32,40-41,49-51,53H,13-16,19-20,34-39H2,1-9H3,(H,59,63)(H,60,65)/t49?,50-,51-,53-,72?/m0/s1

Synonyms: Biotin(N-BB) CE Phosphoramidite; Biotin(N-BB) Phosphoramidite; Biotin (BB) CE phosphoramidite; Biotin (BB) phosphoramidite; Biotin (BB)TM Phosphoramidite