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Phosphoramidites

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2'-Modified Phosphoramidites
(535/535) 2'-Phosphoramidites
(27/27) 3'-Modified Phosphoramidites
(201/201) 5'-Modified Phosphoramidites
(34/34) Arabino Phosphoramidites
(24/24) Base Protected Phosphoramidites (423/423) Dye Phosphoramidites
(64/64) Label Phosphoramidites
(81/81) Linker Phosphoramidites
(91/91) Other Phosphoramidites
(93/93) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(25/25) Spacer Phosphoramidites
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Reverse Abasic Phosphoramidite

Description: Reverse Abasic Phosphoramidite is a specialized compound used in oligonucleotide synthesis. It allows for the controlled introduction of abasic sites, which are sites lacking a nucleobase, into oligonucleotide sequences. These abasic sites serve as versatile molecular tools for various applications in molecular biology, including studying nucleic acid structure, elucidating enzyme kinetics, and investigating nucleic acid-protein interactions.
CAT: BRP-00740
CAS: 401813-16-9
Molecular Formula: C35H45N2O6P
Molecular Weight: 620.73
Purity: >98%
Appearance: White to faint yellow powder
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Storage: Store at -20 °C
InChIKey: WPNQXLQBMSUHFX-JUWSMZLESA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1C(CCO1)OC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC
IUPAC Name: 3-[[(2R,3S)-3-[bis(4-methoxyphenyl)-phenylmethoxy]oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C35H45N2O6P/c1-26(2)37(27(3)4)44(41-23-10-22-36)42-25-34-33(21-24-40-34)43-35(28-11-8-7-9-12-28,29-13-17-31(38-5)18-14-29)30-15-19-32(39-6)20-16-30/h7-9,11-20,26-27,33-34H,10,21,23-25H2,1-6H3/t33-,34+,44?/m0/s1
Synonyms: D-erythro-Pentitol, 1,4-anhydro-3-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-, 2-cyanoethyl bis(1-methylethyl)phosphoramidite; 3'-O-(4,4'-dimethoxytrityl)-1',2'-Dideoxy D-ribose-5'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; ((2R,3S)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

N4-Ac-7'-OH-N-trityl Morpholino cytosine

Description: N4-Ac-7'-OH-N-trityl Morpholino cytosine may have various applications in medicinal chemistry, particularly in the development of pharmaceuticals or as a building block in organic synthesis. Its specific structure suggests potential biological activity or affinity for certain receptors or enzymes, making it of interest in drug discovery or chemical biology research.
CAT: BRP-00741
Molecular Formula: C30H30N4O4
Molecular Weight: 510.59
Purity: >98%
Appearance: White to yellow powder
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Density: 1.25±0.1 g/cm3
InChIKey: LUTKQLULCNFMMH-XTEPFMGCSA-N
CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2CN(CC(O2)CO)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
IUPAC Name: N-[1-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]acetamide
InChI: InChI=1S/C30H30N4O4/c1-22(36)31-27-17-18-34(29(37)32-27)28-20-33(19-26(21-35)38-28)30(23-11-5-2-6-12-23,24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-18,26,28,35H,19-21H2,1H3,(H,31,32,36,37)/t26-,28+/m0/s1
Synonyms: N-[1,2-Dihydro-1-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-2-oxo-4-pyrimidinyl]acetamide; N-(1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

6-Ac-7'-OH-N-trityl morpholino adenosine

Description: 6-Ac-7'-OH-N-trityl morpholino adenosine may have applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting purine receptors or enzymes involved in purine metabolism. Its specific structure suggests potential biological activity, making it of interest in drug discovery or chemical biology research.
CAT: BRP-00742
Molecular Formula: C31H30N6O3
Molecular Weight: 534.62
Purity: >98%
Appearance: White to yellow powder
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InChIKey: URLFNHWSISCXNB-RRPNLBNLSA-N
CanonicalSMILES: CC(=O)NC1=C2C(=NC=N1)N(C=N2)C3CN(CC(O3)CO)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6
IUPAC Name: N-[9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]purin-6-yl]acetamide
InChI: InChI=1S/C31H30N6O3/c1-22(39)35-29-28-30(33-20-32-29)37(21-34-28)27-18-36(17-26(19-38)40-27)31(23-11-5-2-6-12-23,24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-16,20-21,26-27,38H,17-19H2,1H3,(H,32,33,35,39)/t26-,27+/m0/s1
Synonyms: N-(9-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-9H-purin-6-yl)acetamide; N-[9-[(2R,6S)-6-(Hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-9H-purin-6-yl]acetamide; N6-Ac-7'-OH-N-trityl morpholino adenosine

GalNAc-L96 Phosphoramidite

Description: GalNAc-L96 Phosphoramidite is a specialized chemical compound used in oligonucleotide synthesis, particularly in the synthesis of RNA molecules with specific modifications. It contains a GalNAc (N-acetylgalactosamine) group attached to the 5' position of a nucleoside via a linker, allowing for the site-specific incorporation of GalNAc into RNA sequences. This modification mimics natural post-transcriptional modifications found in RNA molecules, such as glycosylation, and can alter the properties and functions of RNA. GalNAc-L96 Phosphoramidite is valuable in research areas such as RNA therapeutics and functional genomics, where modified RNA molecules are used for targeted gene regulation or diagnostic purposes.
CAT: BRP-00743
Molecular Formula: C126H192N13O43P
Molecular Weight: 2607.94
Purity: 98%
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Storage: Store at -20 °C
InChIKey: GJNRYTJOWJMTKY-LXXTXPAYSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(N(C1)C(=O)CCCCCCCCCCC(=O)NC(COCCC(=O)NCCCNC(=O)CCCCOC2C(C(C(C(O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)(COCCC(=O)NCCCNC(=O)CCCCOC3C(C(C(C(O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)COCCC(=O)NCCCNC(=O)CCCCOC4C(C(C(C(O4)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
IUPAC Name: [(2R,3R,4R,5R,6R)-5-acetamido-6-[5-[3-[3-[3-[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]-2-[[12-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypyrrolidin-1-yl]-12-oxododecanoyl]amino]propoxy]propanoylamino]propylamino]-5-oxopentoxy]-3,4-diacetyloxyoxan-2-yl]methyl acetate
InChI: InChI=1S/C126H192N13O43P/c1-81(2)139(82(3)4)183(172-68-36-58-127)182-101-72-98(74-171-126(95-40-26-25-27-41-95,96-47-51-99(160-17)52-48-96)97-49-53-100(161-18)54-50-97)138(73-101)112(159)46-29-24-22-20-19-21-23-28-45-111(158)137-125(78-162-69-55-108(155)131-62-37-59-128-105(152)42-30-33-65-165-122-113(134-83(5)140)119(176-92(14)149)116(173-89(11)146)102(179-122)75-168-86(8)143,79-163-70-56-109(156)132-63-38-60-129-106(153)43-31-34-66-166-123-114(135-84(6)141)120(177-93(15)150)117(174-90(12)147)103(180-123)76-169-87(9)144)80-164-71-57-110(157)133-64-39-61-130-107(154)44-32-35-67-167-124-115(136-85(7)142)121(178-94(16)151)118(175-91(13)148)104(181-124)77-170-88(10)145/h25-27,40-41,47-54,81-82,98,101-104,113-124H,19-24,28-39,42-46,55-57,59-80H2,1-18H3,(H,128,152)(H,129,153)(H,130,154)(H,131,155)(H,132,156)(H,133,157)(H,134,140)(H,135,141)(H,136,142)(H,137,158)/t98-,101+,102+,103+,104+,113+,114+,115+,116-,117-,118-,119+,120+,121+,122+,123+,124+,183?/m0/s1
Synonyms: GalNAc Phosphoramidite; GalNac-L96

Unylinker

Description: Unylinker is a versatile linker molecule used in oligonucleotide synthesis and conjugation chemistry. It provides a stable yet cleavable bond between biomolecules or solid supports, allowing for controlled release or attachment.
CAT: BRP-00754
CAS: 852684-08-3
Molecular Formula: C39H35NO10 (free acid)
Molecular Weight: 677.71 (free acid)
Purity: >98%
Appearance: White to yellow powder
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Density: 1.41±0.1 g/cm3
Boiling Point: 871.5±65.0 °C at 760 mmHg
InChIKey: KPROLRFVRRGFBD-VXPJIIKRNA-N
CanonicalSMILES: O=C(O)CCC(=O)OC1C(OC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C5OC1C6C(=O)N(C(=O)C56)C=7C=CC=CC7
IUPAC Name: rel-4-(((3aR,4R,5R,6S,7S,7aS)-6-(bis(4-methoxyphenyl)(phenyl)methoxy)-1,3-dioxo-2-phenyloctahydro-1H-4,7-epoxyisoindol-5-yl)oxy)-4-oxobutanoic acid
InChI: InChI=1/C39H35NO10/c1-46-27-17-13-24(14-18-27)39(23-9-5-3-6-10-23,25-15-19-28(47-2)20-16-25)50-36-34-32-31(33(49-34)35(36)48-30(43)22-21-29(41)42)37(44)40(38(32)45)26-11-7-4-8-12-26/h3-20,31-36H,21-22H2,1-2H3,(H,41,42)/t31-,32+,33-,34+,35-,36+/s2
Synonyms: Butanedioic acid, 1-[(3aR,4R,5R,6S,7S,7aS)-6-[bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] ester, rel-; Butanedioic acid, mono[(3aR,4R,5R,6S,7S,7aS)-6-[bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] ester, rel-; rel-1-[(3aR,4R,5R,6S,7S,7aS)-6-[Bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] butanedioate; UnyLinker
Related CAS: 852684-09-4 (TEA salt)

Unylinker TEA salt

Description: Unylinker is a versatile linker molecule used in oligonucleotide synthesis and conjugation chemistry. It provides a stable yet cleavable bond between biomolecules or solid supports, allowing for controlled release or attachment. In its TEA (triethylammonium) salt form, it enhances solubility and stability, facilitating its application in various biochemical assays and protocols.
CAT: BRP-00755
CAS: 852684-09-4
Molecular Formula: C39H35NO10.C6H15N
Molecular Weight: 778.89
Purity: >98%
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InChIKey: UOLREVIUECQZSG-LEPPYWKBNA-N
CanonicalSMILES: O=C(O)CCC(=O)OC1C(OC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C5OC1C6C(=O)N(C(=O)C56)C=7C=CC=CC7.N(CC)(CC)CC
IUPAC Name: rel-4-(((3aR,4R,5R,6S,7S,7aS)-6-(bis(4-methoxyphenyl)(phenyl)methoxy)-1,3-dioxo-2-phenyloctahydro-1H-4,7-epoxyisoindol-5-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine
InChI: InChI=1/C39H35NO10.C6H15N/c1-46-27-17-13-24(14-18-27)39(23-9-5-3-6-10-23,25-15-19-28(47-2)20-16-25)50-36-34-32-31(33(49-34)35(36)48-30(43)22-21-29(41)42)37(44)40(38(32)45)26-11-7-4-8-12-26;1-4-7(5-2)6-3/h3-20,31-36H,21-22H2,1-2H3,(H,41,42);4-6H2,1-3H3/t31-,32+,33-,34+,35-,36+;/s2
Synonyms: Butanedioic acid, 1-[(3aR,4R,5R,6S,7S,7aS)-6-[bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] ester, rel-, compd. with N,N-diethylethanamine (1:1); Butanedioic acid, mono[(3aR,4R,5R,6S,7S,7aS)-6-[bis(4-methoxyphenyl)phenylmethoxy]octahydro-1,3-dioxo-2-phenyl-4,7-epoxy-1H-isoindol-5-yl] ester, rel-, compd. with N,N-diethylethanamine (1:1); UnyLinker triethylamine salt
Related CAS: 852684-08-3 (free base)

O(6)-NPE-Morpholino G(iBu) succinate, TEA salt

Description: O(6)-NPE-Morpholino G(iBu) succinate, TEA salt imparts unique properties suitable for applications such as antisense oligonucleotide synthesis and nucleic acid-based therapeutics.
CAT: BRP-00756
Molecular Formula: C45H45N7O9 (free acid)
Molecular Weight: 827.90 (free acid)
Purity: >98%
Appearance: White to yellow powder
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Storage: Store at -20 °C, in tightly closed containers, protected from humidity
IUPAC Name: 4-(((2S,6R)-6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)-4-oxobutanoic acid;N,N-diethylethanamine
Synonyms: 4-((6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)-4-oxobutanoic acid, triethylamine salt

Morpholino C(Bz) succinate, TEA salt

Description: Morpholino C(Bz) succinate, TEA salt confers stability and controlled reactivity during oligonucleotide assembly, making them valuable tools in nucleic acid research and therapeutic development.
CAT: BRP-00757
Molecular Formula: C39H36N4O7 (free acid)
Molecular Weight: 672.74 (free acid)
Purity: >98%
Appearance: White to yellow powder
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Storage: Store at -20 °C, in tightly closed containers, protected from humidity
IUPAC Name: 4-[[(2S,6R)-6-(4-benzamido-2-oxopyrimidin-1-yl)-4-tritylmorpholin-2-yl]methoxy]-4-oxobutanoic acid;N,N-diethylethanamine
Synonyms: Butanedioic acid, 1-[[(2S,6R)-6-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl] ester triethylamine salt; 4-[[(2S,6R)-6-(4-Benzamide-2-oxopyrimidine-1(2H)-yl)-4-tritylmorpholine-2-yl]methoxy]-4-oxobutyric acid triethylamine salt; 4-[[(2S,6R)-6-(4-Benzamido-2-oxopyrimidin-1-yl)-4-tritylmorpholin-2-yl]methoxy]-4-oxobutanoic acid triethylamine salt; 1-[[(2S,6R)-6-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl] butanedioate triethylamine salt
Related CAS: 1362664-31-0 (free base)

Morpholino A(Bz) succinate, TEA salt

Description: Morpholino A(Bz) succinate, TEA salt confers stability and controlled reactivity during oligonucleotide assembly, making them valuable tools in nucleic acid research and therapeutic development.
CAT: BRP-00758
Molecular Formula: C40H36N6O6 (free acid)
Molecular Weight: 696.76 (free acid)
Purity: >98%
Appearance: White to yellow powder
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Storage: Store at -20 °C, in tightly closed containers, protected from humidity
IUPAC Name: 4-[[(2S,6R)-6-(6-benzamidopurin-9-yl)-4-tritylmorpholin-2-yl]methoxy]-4-oxobutanoic acid;N,N-diethylethanamine
Synonyms: 4-(((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)-4-oxobutanoic acid triethylamine salt; 1-[[(2S,6R)-6-[6-(Benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl] butanedioate triethylamine salt; Butanedioic acid, 1-[[(2S,6R)-6-[6-(benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl] ester triethylamine salt; 4-((6-(6-benzamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)-4-oxobutanoic acid, triethylamine salt
Related CAS: 1446206-67-2 (free base)

N-Trityl-N4-benzoyl-morpholino-C-7'-O-phosphoramidite

Description: Morpholino nucleoside phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives
CAT: BRP-00762
CAS: 2434794-97-3
Molecular Formula: C44H49N6O5P
Molecular Weight: 772.87
Purity: ≥97% by HPLC
Appearance: White to off-white foam solid
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Storage: Store at -20 °C, under inert atmosphere
InChIKey: BUAVHKSBQVLXPP-SKSUEDBOSA-N
Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1CN(CC(O1)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6
IUPAC Name: N-[1-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C44H49N6O5P/c1-33(2)50(34(3)4)56(53-29-17-27-45)54-32-39-30-48(31-41(55-39)49-28-26-40(47-43(49)52)46-42(51)35-18-9-5-10-19-35)44(36-20-11-6-12-21-36,37-22-13-7-14-23-37)38-24-15-8-16-25-38/h5-16,18-26,28,33-34,39,41H,17,29-32H2,1-4H3,(H,46,47,51,52)/t39-,41+,56?/m0/s1
Synonyms: N-Trityl-N4-benzoyl-morpholino-C-5'-O-phosphoramidite; ((2S,6R)-6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

5'-O-DMTr-2'-O-methyl-N6-methyl adenosine 3'-CED phosphoramidite

Description: Phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives.
CAT: BRP-00763
CAS: 2348385-04-4
Molecular Formula: C42H52N7O7P
Molecular Weight: 797.88
Purity: ≥97% by HPLC
Appearance: White to off-white foam solid
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Storage: Store at -20 °C, under inert atmosphere
InChIKey: XXRTXDUOPCNYDH-DJADKNTFSA-N
Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C42H52N7O7P/c1-28(2)49(29(3)4)57(54-24-12-23-43)56-37-35(55-41(38(37)52-8)48-27-47-36-39(44-5)45-26-46-40(36)48)25-53-42(30-13-10-9-11-14-30,31-15-19-33(50-6)20-16-31)32-17-21-34(51-7)22-18-32/h9-11,13-22,26-29,35,37-38,41H,12,24-25H2,1-8H3,(H,44,45,46)/t35-,37-,38-,41-,57?/m1/s1
Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite; 5'-O-DMTr-2'-O-methyl-N6-methyladenosine-3'-phosphoramidite

N-Trityl-N2-isobutyryl-morpholino-G-7'-O-phosphoramidite

Description: Morpholino nucleoside phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives.
CAT: BRP-00764
CAS: 2434795-03-4
Molecular Formula: C42H51N8O5P
Molecular Weight: 778.88
Purity: ≥97% by HPLC
Appearance: White to off-white foam solid
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Storage: Store at -20 °C, under inert atmosphere
InChIKey: FRWLFVXCJRIGKK-AUOFHDIISA-N
Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol
CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3CN(CC(O3)COP(N(C(C)C)C(C)C)OCCC#N)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6
IUPAC Name: N-[9-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
InChI: InChI=1S/C42H51N8O5P/c1-29(2)39(51)46-41-45-38-37(40(52)47-41)44-28-49(38)36-26-48(25-35(55-36)27-54-56(53-24-16-23-43)50(30(3)4)31(5)6)42(32-17-10-7-11-18-32,33-19-12-8-13-20-33)34-21-14-9-15-22-34/h7-15,17-22,28-31,35-36H,16,24-27H2,1-6H3,(H2,45,46,47,51,52)/t35-,36+,56?/m0/s1
Synonyms: N-Trityl-N2-isobutyryl-morpholino-G-5'-O-phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl) inosine 3'-CED phosphoramidite

Description: Phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives.
CAT: BRP-00765
Molecular Formula: C43H53N6O9P
Molecular Weight: 828.89
Purity: ≥97% by HPLC
Appearance: White to off-white foam solid
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Storage: Store at -20 °C, under inert atmosphere
InChIKey: FSSPCCHOIYMGBP-NFQMNAKDSA-N
Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-(6-oxo-1H-purin-9-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C43H53N6O9P/c1-29(2)49(30(3)4)59(56-23-11-22-44)58-38-36(57-42(39(38)54-25-24-51-5)48-28-47-37-40(48)45-27-46-41(37)50)26-55-43(31-12-9-8-10-13-31,32-14-18-34(52-6)19-15-32)33-16-20-35(53-7)21-17-33/h8-10,12-21,27-30,36,38-39,42H,11,23-26H2,1-7H3,(H,45,46,50)/t36-,38-,39-,42-,59?/m1/s1
Synonyms: DMTr-MOE-Inosine-3-CED-phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-MOE I amidite

N-Trityl-N6-benzoyl-morpholino-A(Bz)-7'-O-phosphoramidite

Description: Morpholino nucleoside phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives.
CAT: BRP-00766
CAS: 2434795-08-9
Molecular Formula: C45H49N8O4P
Molecular Weight: 796.90
Purity: ≥97% by HPLC
Appearance: White to off-white foam solid
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Storage: Store at -20 °C, under inert atmosphere
InChIKey: PKBMTUUGKIQWLB-SJMRETRVSA-N
Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1CN(CC(O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7
IUPAC Name: N-[9-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]purin-6-yl]benzamide
InChI: InChI=1S/C45H49N8O4P/c1-33(2)53(34(3)4)58(55-27-17-26-46)56-30-39-28-51(45(36-20-11-6-12-21-36,37-22-13-7-14-23-37)38-24-15-8-16-25-38)29-40(57-39)52-32-49-41-42(47-31-48-43(41)52)50-44(54)35-18-9-5-10-19-35/h5-16,18-25,31-34,39-40H,17,27-30H2,1-4H3,(H,47,48,50,54)/t39-,40+,58?/m0/s1
Synonyms: N-Trityl-N6-benzoyl-morpholino-A-5'-O-phosphoramidite; N-Trityl-N6-benzoyl-morpholino-A-7'-O-phosphoramidite; ((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

Lipid Phosphoramidite

Description: Lipid Phosphoramidite is a phosphoramidite derivative used in solid-phase synthesis of lipid-modified oligonucleotides. It contains a lipid moiety attached to a phosphoramidite backbone, facilitating the conjugation of oligonucleotides with lipids for applications such as drug delivery and gene silencing.
CAT: BRP-00771
CAS: 207273-85-6
Molecular Formula: C48H95N4O4P
Molecular Weight: 823.27
Purity: ≥95%
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InChIKey: GXAMBDAWMKUULA-UHFFFAOYSA-N
CanonicalSMILES: CCCCCCCCCCCCCCCCCC(=O)NCC(CNC(=O)CCCCCCCCCCCCCCCCC)OP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: N-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(octadecanoylamino)propyl]octadecanamide
InChI: InChI=1S/C48H95N4O4P/c1-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-47(53)50-42-46(56-57(55-41-37-40-49)52(44(3)4)45(5)6)43-51-48(54)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-2/h44-46H,7-39,41-43H2,1-6H3,(H,50,53)(H,51,54)
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl ester; 2-cyanoethyl (1,3-distearamidopropan-2-yl) diisopropylphosphoramidite; 2-Cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl ester

Biotin (BB) CED phosphoramidite

Description: Biotin (BB) CED phosphoramidite is a phosphoramidite derivative used for the synthesis of biotinylated oligonucleotides. It contains a biotin moiety attached to a phosphoramidite backbone, enabling the specific labeling and purification of nucleic acids using biotin-streptavidin affinity methods.
CAT: BRP-00772
Molecular Formula: C57H76N5O9PS
Molecular Weight: 1038.28
Purity: ≥97% by HPLC
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: YMYNFOUBKWAXFH-YRZSEFLFSA-N
IUPAC Name: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(3-(5-((3aS,4S,6aR)-1-(4-(tert-butyl)benzoyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)propoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C57H76N5O9PS/c1-40(2)62(41(3)4)72(70-36-15-33-58)71-49(38-69-57(44-17-11-10-12-18-44,45-25-29-47(66-8)30-26-45)46-27-31-48(67-9)32-28-46)37-68-35-16-34-59-52(63)20-14-13-19-51-53-50(39-73-51)61(55(65)60-53)54(64)42-21-23-43(24-22-42)56(5,6)7/h10-12,17-18,21-32,40-41,49-51,53H,13-16,19-20,34-39H2,1-9H3,(H,59,63)(H,60,65)/t49?,50-,51-,53-,72?/m0/s1
Synonyms: Biotin(N-BB) CE Phosphoramidite; Biotin(N-BB) Phosphoramidite; Biotin (BB) CE phosphoramidite; Biotin (BB) phosphoramidite; Biotin (BB)TM Phosphoramidite

12-(Trifluoroacetylamino)-hexyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

Description: 12-(Trifluoroacetylamino)-hexyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite is a phosphoramidite derivative used in oligonucleotide synthesis. It contains a hexyl chain modified with a trifluoroacetyl group and a cyanoethyl protecting group attached to a phosphoramidite backbone, facilitating efficient coupling reactions during solid-phase synthesis.
CAT: BRP-00773
CAS: 2087458-61-3
Molecular Formula: C23H43F3N3O3P
Molecular Weight: 497.58
Purity: ≥95%
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InChIKey: UOXSQLQMSFUIRH-UHFFFAOYSA-N
CanonicalSMILES: N#CCCOP(OCCCCCCCCCCCCNC(=O)C(F)(F)F)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl (12-(2,2,2-trifluoroacetamido)dodecyl) diisopropylphosphoramidite
InChI: InChI=1S/C23H43F3N3O3P/c1-20(2)29(21(3)4)33(32-19-15-16-27)31-18-14-12-10-8-6-5-7-9-11-13-17-28-22(30)23(24,25)26/h20-21H,5-15,17-19H2,1-4H3,(H,28,30)
Synonyms: 5'-Amino-Modifier C12-TFA phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 12-[(2,2,2-trifluoroacetyl)amino]dodecyl ester; 2-Cyanoethyl 12-[(2,2,2-trifluoroacetyl)amino]dodecyl N,N-bis(1-methylethyl)phosphoramidite; TFA-Amino C-12 CED phosphoramidite; 5'-Amino-Modifier C12-TFA

GalNAc-Cluster-HHA-CE Phosphoramidite

Description: GalNAc-Cluster-HHA-CE Phosphoramidite is a specialized compound utilized in oligonucleotide synthesis. It contains N-acetylgalactosamine clusters and a glycan-binding unit (HHA-CE), enabling the study of glycan-protein interactions, crucial in glycobiology and drug development.
CAT: BRP-00784
CAS: 2550328-16-8
Molecular Formula: C93H155N10O43P
Molecular Weight: 2132.24
Purity: ≥98%
Appearance: White solid
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Storage: Store at 2-8 °C
InChIKey: YBEYXGGMLIQBIC-AKUCVXOZSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C(CCCCNC(=O)COCCOCCOCCOC1C(C(C(C(O1)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)NC(=O)C(CCCCNC(=O)COCCOCCOCCOC2C(C(C(C(O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)NC(=O)COCCOCCOCCOC3C(C(C(C(O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)OCCC#N
IUPAC Name: [(2R,3R,4R,5R,6R)-5-acetamido-6-[2-[2-[2-[2-[[(5S)-5-[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]-6-[[(2R)-6-[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]-1-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylamino]-1-oxohexan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethoxy]ethoxy]-3,4-diacetyloxyoxan-2-yl]methyl acetate
InChI: InChI=1S/C93H155N10O43P/c1-58(2)103(59(3)4)147(137-33-25-28-94)136-32-24-18-17-21-31-97-89(119)72(26-19-22-29-95-77(116)55-127-43-40-121-34-37-124-46-49-130-91-80(98-60(5)104)86(141-69(14)113)83(138-66(11)110)74(144-91)52-133-63(8)107)102-90(120)73(101-79(118)57-129-45-42-123-36-39-126-48-51-132-93-82(100-62(7)106)88(143-71(16)115)85(140-68(13)112)76(146-93)54-135-65(10)109)27-20-23-30-96-78(117)56-128-44-41-122-35-38-125-47-50-131-92-81(99-61(6)105)87(142-70(15)114)84(139-67(12)111)75(145-92)53-134-64(9)108/h58-59,72-76,80-88,91-93H,17-27,29-57H2,1-16H3,(H,95,116)(H,96,117)(H,97,119)(H,98,104)(H,99,105)(H,100,106)(H,101,118)(H,102,120)/t72-,73+,74-,75-,76-,80-,81-,82-,83+,84+,85+,86-,87-,88-,91-,92-,93-,147?/m1/s1

DMT-LNA-5mC phosphoramidite

Description: DMT-LNA-5mC phosphoramidite is a modified phosphoramidite used in the synthesis of Locked Nucleic Acid (LNA) oligonucleotides. It features a 5-methylcytosine (5mC) base, a DMT (dimethoxytrityl) protecting group, and a phosphoramidite group. This modification increases the thermal stability and binding affinity of the oligonucleotide, making it useful in antisense therapy, siRNA development, and molecular biology techniques.
CAT: BRP-00811
CAS: 1184723-53-2
Molecular Formula: C41H50N5O8P
Molecular Weight: 771.84
Purity: 98%
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Storage: Store at 2-8 °C, stored under nitrogen
InChIKey: UJUKPCINNDKWEN-ZRCIEBSPSA-N
CanonicalSMILES: CC1=CN(C(=O)N=C1N)C2C3C(C(O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: 3-[[(1R,3R,4R,7S)-3-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C41H50N5O8P/c1-27(2)46(28(3)4)55(52-23-11-22-42)54-36-35-38(45-24-29(5)37(43)44-39(45)47)53-40(36,25-50-35)26-51-41(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-21,24,27-28,35-36,38H,11,23,25-26H2,1-7H3,(H2,43,44,47)/t35-,36+,38-,40-,55?/m1/s1
Synonyms: LNA-5-Me-C-CE Phosphoramidite; DMT-LNA-5mA phosphoramidite; 2(1H)-Pyrimidinone, 4-amino-1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-5-methyl-; 4-Amino-1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-5-methyl-2(1H)-pyrimidinone

DMT-LNA-G phosphoramidite

Description: DMT-LNA-G phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis, specifically for Locked Nucleic Acid (LNA) oligonucleotides. It contains a guanosine base modified with Locked Nucleic Acid (LNA) chemistry and a DMT (dimethoxytrityl) protecting group. This modification enhances the stability and binding affinity of the oligonucleotide to its complementary DNA or RNA strand. DMT-LNA-G phosphoramidite is commonly used in applications such as antisense therapy, PCR, and molecular diagnostics, where increased specificity and stability are required.
CAT: BRP-00812
CAS: 207131-17-7
Molecular Formula: C41H48N7O8P
Molecular Weight: 797.84
Purity: 98%
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Storage: Store at 2-8 °C, stored under nitrogen
InChIKey: FWLGFXLWSNDRLS-NVONNAQSSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=C(NC7=O)N
IUPAC Name: 3-[[(1R,3R,4R,7S)-3-(2-amino-6-oxo-1H-purin-9-yl)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C41H48N7O8P/c1-26(2)48(27(3)4)57(54-22-10-21-42)56-35-34-38(47-25-44-33-36(47)45-39(43)46-37(33)49)55-40(35,23-52-34)24-53-41(28-11-8-7-9-12-28,29-13-17-31(50-5)18-14-29)30-15-19-32(51-6)20-16-30/h7-9,11-20,25-27,34-35,38H,10,22-24H2,1-6H3,(H3,43,45,46,49)/t34-,35+,38-,40-,57?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O,4'-C-methylene-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (1R,3R,4R,7S)-3-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite
* Only for research. Not suitable for any diagnostic or therapeutic use.

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