What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

LNA-C(Ac)-CE Phosphoramidite

Description: LNA-C(Ac)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a cytosine base modified with an acetyl (Ac) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the acetyl modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

CAT: BRP-00389

Molecular Formula: C42H50N5O9P

Molecular Weight: 799.86

Purity: ≥95%

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InChIKey: VLHUEAKCEPSXIL-WFNFTXKBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=NC6=O)NC(=O)C

IUPAC Name: N-[1-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C42H50N5O9P/c1-28(2)47(29(3)4)57(54-25-11-23-43)56-38-37-39(46-24-22-36(44-30(5)48)45-40(46)49)55-41(38,26-52-37)27-53-42(31-12-9-8-10-13-31,32-14-18-34(50-6)19-15-32)33-16-20-35(51-7)21-17-33/h8-10,12-22,24,28-29,37-39H,11,25-27H2,1-7H3,(H,44,45,48,49)/t37-,38+,39-,41-,57?/m1/s1

Synonyms: N6-Acetyl-5'-O-(4,4'-dimethoxytrityl)-LNA-cytidine-3'-cyanoethyl phosphoramidite; 5'-O-DMTr-2'-O-4'-C-Locked-C(Ac) Phosphoramidite; DMT-locC(Ac)Amidite; DMT-locC(Ac) phosphoramidite; DMTr-LNA-C(Ac)-3-CED-phosphoramidite; N6-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-C(Ac)-3-CED-phosphoramidite; Ac-C-LA-CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-rC(Ac)-3'-CE-Phosphoramidite; N4-Acetyl-5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-4'-C-Locked-cytidine-3'-CE Phosphoramidite; N4-Ac-2'-O-4'-C-Locked-Cr-CE-Phosphoramidite

LNA-G(dmf)-CE Phosphoramidite

Description: LNA-G(dmf)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a guanine base modified with a dimethylformamide (dmf) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the dmf modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

CAT: BRP-00390

CAS: 709641-79-2

Molecular Formula: C44H53N8O8P

Molecular Weight: 852.91

Purity: ≥95%

Appearance: Off-white to yellow powder

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InChIKey: ACJXYPZQPQPGNE-KPKUBJDASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=C(NC7=O)N=CN(C)C

IUPAC Name: N'-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C44H53N8O8P/c1-29(2)52(30(3)4)61(58-24-12-23-45)60-38-37-41(51-28-46-36-39(51)48-42(49-40(36)53)47-27-50(5)6)59-43(38,25-56-37)26-57-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,37-38,41H,12,24-26H2,1-8H3,(H,48,49,53)/t37-,38+,41-,43-,61?/m1/s1

Synonyms: 2'-O-4'-C-Locked-rG(dmf) Phosphoramidite; 5'-Dimethoxytrityl-N-dimethylformamidine-(2'-O,4'-C-methylene)-Guanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dmf-G-LA-CE Phosphoramidite; 5'-DMT-LNA-Guanosine(N-dmf) CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite; N'-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide; DMT-2'-O-4'-C-Locked-G(dmf)-CE; LNA-G(dmf) phosphoramidite; N2-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-Guanosine-3'-cyanoethyl Phosphoramidite; N2-dmf-2'-O-4'-C-Locked-Gr-CE-Phosphoramidite

LNA-U-CE Phosphoramidite

Description: LNA-U-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a locked nucleic acid (LNA) backbone with a uracil base and includes a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced stability and affinity for complementary sequences, making them valuable in molecular biology research for applications such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays. This phosphoramidite variant specifically provides increased stability and specificity in oligonucleotide design, contributing to more effective molecular tools for diverse research needs.

CAT: BRP-00391

CAS: 206055-76-7

Molecular Formula: C40H47N4O9P

Molecular Weight: 758.81

Purity: ≥95%

Appearance: White to off-white solid

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Storage: Store at 2-8 °C, stored under nitrogen

InChIKey: ROCIJWWVBQZMMI-PUIMFIDCSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=O)NC6=O

IUPAC Name: 3-[[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H47N4O9P/c1-27(2)44(28(3)4)54(51-24-10-22-41)53-36-35-37(43-23-21-34(45)42-38(43)46)52-39(36,25-49-35)26-50-40(29-11-8-7-9-12-29,30-13-17-32(47-5)18-14-30)31-15-19-33(48-6)20-16-31/h7-9,11-21,23,27-28,35-37H,10,24-26H2,1-6H3,(H,42,45,46)/t35-,36+,37-,39-,54?/m1/s1

Synonyms: DMTr-LNA-U-3-CED-phosphoramidite; 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-2,4(1H,3H)-pyrimidinedione; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O,4'-C-methylene-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMTr-2'-O-4'-C-Locked-rU-3'-CE-Phosphoramidite; 5'-O-DMTr-2'-O,4'-C-methyleneuridine 3'-CE-phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-4'-C-Locked-uridine-3'-CE Phosphoramidite; 2'-O-4'-C-Locked-Ur-CE-Phosphoramidite

DMT-2'-O-4'-C Locked-Tr-CE Phosphoramidite

Description: DMT-2'-O-4'-C Locked-Tr-CE Phosphoramidite is a phosphoramidite compound used for the synthesis of locked nucleic acids (LNAs). This molecule is derived from a nucleoside and features several key modifications: a dimethoxytrityl (DMT) group at the 5' position, a 2'-O-4'-C methylene bridge (creating a locked ribose conformation), and a cyanoethyl (CE) phosphoramidite group for incorporation into oligonucleotides. DMT-2'-O-4'-C Locked-Tr-CE Phosphoramidite is valuable in various applications, including antisense therapy, siRNA, miRNA research, and diagnostic assays. The enhanced stability and binding properties of LNA-modified oligonucleotides make them powerful tools in molecular biology and medical research, providing greater specificity and efficacy in targeting RNA or DNA sequences.

CAT: BRP-00393

CAS: 206055-75-6

Molecular Formula: C41H49N4O9P

Molecular Weight: 772.84

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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InChIKey: STPXOEPMLLHUDQ-ZRCIEBSPSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C3C(C(O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H49N4O9P/c1-27(2)45(28(3)4)55(52-23-11-22-42)54-36-35-38(44-24-29(5)37(46)43-39(44)47)53-40(36,25-50-35)26-51-41(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-21,24,27-28,35-36,38H,11,23,25-26H2,1-7H3,(H,43,46,47)/t35-,36+,38-,40-,55?/m1/s1

Synonyms: DMTr-LNA-5MeU-3-CED-phosphoramidite; 5'-O-DMT-2'-O,4'-C-methylene-5-methyluridine 3'-CE-phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-thymidine-3'-cyanoethyl Phosphoramidite; 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 5'-O-(4,4'-Dimethoxytrityl)-LNA-thymidine-3'-cyanoethyl phosphoramidite; DMT-locT Amidite; LNA-T phosphoramidite

DMTr-LNA-A(Bz)-3-CED-phosphoramidite

Description: DMTr-LNA-A(Bz)-3'-CED-phosphoramidite is a chemically modified nucleotide used in the synthesis of oligonucleotides. It features an adenine base (A) with a benzoyl (Bz) protecting group, incorporated into a locked nucleic acid (LNA) structure. The nucleotide has a dimethoxytrityl (DMTr) protecting group at the 5' position and a cyanoethyl diisopropylamino (CED) phosphoramidite group at the 3' position. This modification enhances the stability and binding affinity of oligonucleotides, making it useful for advanced genetic and molecular biology research, as well as for the development of therapeutic nucleic acids. It can be used for the synthesis of ASOs (antisense oligonucleotides).

CAT: BRP-00394

CAS: 206055-79-0

Molecular Formula: C48H52N7O8P

Molecular Weight: 885.96

Purity: ≥95%

Appearance: White to off-white solid

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Storage: Store at 2-8 °C, protect from light

InChIKey: HPIDKMAOZZZGOP-LIUGLABVSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C(N=CN=C76)NC(=O)C8=CC=CC=C8

IUPAC Name: N-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]purin-6-yl]benzamide

InChI: InChI=1S/C48H52N7O8P/c1-32(2)55(33(3)4)64(61-27-13-26-49)63-42-41-46(54-31-52-40-43(50-30-51-44(40)54)53-45(56)34-14-9-7-10-15-34)62-47(42,28-59-41)29-60-48(35-16-11-8-12-17-35,36-18-22-38(57-5)23-19-36)37-20-24-39(58-6)25-21-37/h7-12,14-25,30-33,41-42,46H,13,27-29H2,1-6H3,(H,50,51,53,56)/t41-,42+,46-,47-,64?/m1/s1

Synonyms: N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-9H-purin-6-yl]benzamide; N6-Bz-2'-O-4'-A-Locked-Ar-CE-Phosphoramidite; DMT-locA(bz)Amidite; LNA-A(Bz) amidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-adenosine-3'-cyanoethyl Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-LNA-adenosine-3'-cyanoethyl phosphoramidite; LNA-A(Bz)-CE Phosphoramidite; Bz-A-LA-CE Phosphoramidite

6-ROX-Phosphoramidite

Description: 6-ROX-Phosphoramidite is a fluorescent dye phosphoramidite used in the synthesis of labeled oligonucleotides. The 6-ROX (6-carboxy-X-rhodamine) dye is known for its strong fluorescence and is often used in molecular biology applications, such as real-time PCR, DNA sequencing, and fluorescence in situ hybridization (FISH). Incorporating 6-ROX into oligonucleotides allows for the visualization and tracking of nucleic acids in various research and diagnostic applications.

CAT: BRP-00400

Molecular Formula: C48H60N5O6P

Molecular Weight: 834.01

Purity: ≥97%

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InChIKey: OVEHZTATEJWCCS-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC(=C(C=C1)C(=O)[O-])C2=C3C=C4CCC[N+]5=C4C(=C3OC6=C2C=C7CCCN8C7=C6CCC8)CCC5)OCCC#N

IUPAC Name: 4-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-2-(3-oxa-23-aza-9-azoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-16-yl)benzoate

InChI: InChI=1S/C48H60N5O6P/c1-31(2)53(32(3)4)60(58-27-13-20-49)57-26-8-6-5-7-21-50-47(54)35-18-19-36(48(55)56)39(30-35)42-40-28-33-14-9-22-51-24-11-16-37(43(33)51)45(40)59-46-38-17-12-25-52-23-10-15-34(44(38)52)29-41(42)46/h18-19,28-32H,5-17,21-27H2,1-4H3,(H-,50,54,55,56)

Synonyms: 6-ROX Phosphoramidite

DMT-2'-O-TBDMS-G(dmf)-CE Phosphoramidite

Description: DMT-2'-O-TBDMS-G(dmf)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group on the 3' hydroxyl, a tert-butyldimethylsilyl (TBDMS) protecting group on the 2' hydroxyl, and a guanine base modified with a dimethylformamide (dmf) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. This compound enables stable and precise synthesis of oligonucleotides for various molecular biology research applications, including gene silencing, antisense therapy, and diagnostics.

CAT: BRP-00402

CAS: 149559-87-5

Molecular Formula: C49H67N8O8PSi

Molecular Weight: 955.18

Purity: ≥95%

Appearance: White to light yellow powder

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InChIKey: RQXRLANMGPTUJP-UTESLAMRSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C49H67N8O8PSi/c1-33(2)57(34(3)4)66(62-29-17-28-50)64-42-40(30-61-49(35-18-15-14-16-19-35,36-20-24-38(59-10)25-21-36)37-22-26-39(60-11)27-23-37)63-46(43(42)65-67(12,13)48(5,6)7)56-32-51-41-44(56)53-47(54-45(41)58)52-31-55(8)9/h14-16,18-27,31-34,40,42-43,46H,17,29-30H2,1-13H3,(H,53,54,58)/t40-,42-,43-,46-,66?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N2-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-N2-DMF-Guanosine 3'-CE phosphoramidite; rG (dmf) CE-Phosphoramidite

5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite is a specialized nucleotide compound utilized in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and an adenine base modified with a benzoyl (Bz) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and offers enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It finds applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00403

Molecular Formula: C52H53N6O8PS2

Molecular Weight: 985.12

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: CLDYJLPUISOESS-LTMMGAFGSA-N

CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N8CCCC8)SCCSC(=O)C9=CC=CC=C9

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C52H53N6O8PS2/c1-61-41-25-21-39(22-26-41)52(38-19-11-6-12-20-38,40-23-27-42(62-2)28-24-40)64-33-43-45(66-67(57-29-13-14-30-57)69-32-31-68-51(60)37-17-9-5-10-18-37)46(63-3)50(65-43)58-35-55-44-47(53-34-54-48(44)58)56-49(59)36-15-7-4-8-16-36/h4-12,15-28,34-35,43,45-46,50H,13-14,29-33H2,1-3H3,(H,53,54,56,59)/t43-,45-,46-,50-,67?/m1/s1

Synonyms: S-(2-(((((2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; DMT-2'-OMe-A(Bz)-3'-PS; [N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-adenosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; 2'-OMe-A-Thiophosphoramidite; 5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-methyl, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite is a specialized nucleotide compound employed in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a guanine base modified with an isobutyl (iBu) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and offers enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It finds applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00404

Molecular Formula: C49H55N6O9PS2

Molecular Weight: 967.11

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: HZMNPGZRUUSWOU-VKFKYRIUSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N7CCCC7)SCCSC(=O)C8=CC=CC=C8)OC

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C49H55N6O9PS2/c1-32(2)44(56)52-48-51-43-40(45(57)53-48)50-31-55(43)46-42(61-5)41(64-65(54-26-12-13-27-54)67-29-28-66-47(58)33-14-8-6-9-15-33)39(63-46)30-62-49(34-16-10-7-11-17-34,35-18-22-37(59-3)23-19-35)36-20-24-38(60-4)25-21-36/h6-11,14-25,31-32,39,41-42,46H,12-13,26-30H2,1-5H3,(H2,51,52,53,56,57)/t39-,41-,42-,46-,65?/m1/s1

Synonyms: DMT-2'-OMe-G(iBu)-3'-PS; [N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine]-3'-[S-(β-(Benzoylmercapto)ethyl)pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; 2'-OMe-G-Thiophosphoramidite; 5'-Dimethoxytrityl-N-isobutyryl-Guanosine, 2'-O-methyl,3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

5'-DMT-2'-O-MOE-G(iBu)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-G(iBu)-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and a guanine base modified with an isobutyl (iBu) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and provides enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It is utilized in various molecular biology research applications, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00405

CAS: 2360826-78-2

Molecular Formula: C51H59N6O10PS2

Molecular Weight: 1011.16

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: HDXVTGDRJQVYMX-MGIZDRFQSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(SCCSC(=O)C=7C=CC=CC7)N8CCCC8)C3OCCOC

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C51H59N6O10PS2/c1-34(2)46(58)54-50-53-45-42(47(59)55-50)52-33-57(45)48-44(64-29-28-61-3)43(67-68(56-26-12-13-27-56)70-31-30-69-49(60)35-14-8-6-9-15-35)41(66-48)32-65-51(36-16-10-7-11-17-36,37-18-22-39(62-4)23-19-37)38-20-24-40(63-5)25-21-38/h6-11,14-25,33-34,41,43-44,48H,12-13,26-32H2,1-5H3,(H2,53,54,55,58,59)/t41-,43-,44-,48-,68?/m1/s1

Synonyms: [N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]

5'-DMT-2'-O-MOE-A(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-A(Bz)-3'-PS-Phosphoramidite is a specialized nucleotide compound utilized in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and an adenine base modified with a benzoyl (Bz) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and offers enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It finds applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00406

CAS: 2360826-72-6

Molecular Formula: C54H57N6O9PS2

Molecular Weight: 1029.18

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: OKYFNXWXBWXJHI-QRWWDSLFSA-N

CanonicalSMILES: O=C(SCCSP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OCCOC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N8CCCC8)C=9C=CC=CC9

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C54H57N6O9PS2/c1-63-31-32-66-48-47(69-70(59-29-13-14-30-59)72-34-33-71-53(62)39-17-9-5-10-18-39)45(68-52(48)60-37-57-46-49(55-36-56-50(46)60)58-51(61)38-15-7-4-8-16-38)35-67-54(40-19-11-6-12-20-40,41-21-25-43(64-2)26-22-41)42-23-27-44(65-3)28-24-42/h4-12,15-28,36-37,45,47-48,52H,13-14,29-35H2,1-3H3,(H,55,56,58,61)/t45-,47-,48-,52-,70?/m1/s1

Synonyms: [N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]

5'-DMT-2'-O-MOE-5-Me-C(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-5-Me-C(Bz)-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and a 5-methylcytosine base modified with a benzoyl (Bz) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and provides enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It is utilized in various molecular biology research applications, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00407

CAS: 2360826-74-8

Molecular Formula: C54H59N4O10PS2

Molecular Weight: 1019.18

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: JHTAVHWNDBSHFT-GDWCHFCQSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)C(=CN1C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(SCCSC(=O)C=7C=CC=CC7)N8CCCC8)C3OCCOC)C

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C54H59N4O10PS2/c1-38-36-58(53(61)56-49(38)55-50(59)39-16-8-5-9-17-39)51-48(65-33-32-62-2)47(68-69(57-30-14-15-31-57)71-35-34-70-52(60)40-18-10-6-11-19-40)46(67-51)37-66-54(41-20-12-7-13-21-41,42-22-26-44(63-3)27-23-42)43-24-28-45(64-4)29-25-43/h5-13,16-29,36,46-48,51H,14-15,30-35,37H2,1-4H3,(H,55,56,59,61)/t46-,47-,48-,51-,69?/m1/s1

Synonyms: [N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-cytidine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]

5'-DMT-2'-OMe-5-Me-C(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-5-Me-C(Bz)-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a 5-methylcytosine base modified with a benzoyl (Bz) group. Additionally, it features a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for applications such as gene synthesis, RNA interference, and nucleic acid probe development in molecular biology research.

CAT: BRP-00408

Molecular Formula: C52H55N4O9PS2

Molecular Weight: 975.12

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: DOVLPDMECIOKGA-BZPNBFHRSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N7CCCC7)SCCSC(=O)C8=CC=CC=C8)OC

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C52H55N4O9PS2/c1-36-34-56(51(59)54-47(36)53-48(57)37-16-8-5-9-17-37)49-46(62-4)45(65-66(55-30-14-15-31-55)68-33-32-67-50(58)38-18-10-6-11-19-38)44(64-49)35-63-52(39-20-12-7-13-21-39,40-22-26-42(60-2)27-23-40)41-24-28-43(61-3)29-25-41/h5-13,16-29,34,44-46,49H,14-15,30-33,35H2,1-4H3,(H,53,54,57,59)/t44-,45-,46-,49-,66?/m1/s1

Synonyms: [N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyl-cytidine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-5-(4-Benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate

5'-DMT-2'-OMe-C(Ac)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-C(Ac)-3'-PS-Phosphoramidite is a specialized nucleotide compound utilized in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a cytidine base modified with an acetyl (Ac) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and provides enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It is employed in various molecular biology research applications, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00409

Molecular Formula: C46H51N4O9PS2

Molecular Weight: 899.03

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: CNCXGATYHORASL-SRYSXPHVSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7)OC

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C46H51N4O9PS2/c1-32(51)47-40-25-28-50(45(53)48-40)43-42(56-4)41(59-60(49-26-11-12-27-49)62-30-29-61-44(52)33-13-7-5-8-14-33)39(58-43)31-57-46(34-15-9-6-10-16-34,35-17-21-37(54-2)22-18-35)36-19-23-38(55-3)24-20-36/h5-10,13-25,28,39,41-43H,11-12,26-27,29-31H2,1-4H3,(H,47,48,51,53)/t39-,41-,42-,43-,60?/m1/s1

Synonyms: DMT-2'-OMe-C(Ac)-3'-PS; [N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyl-cytidine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; 2'-OMe-C-Thiophosphoramidite; 5'-Dimethoxytrityl-N-acetyl-Cytidine, 2'-O-methyl,3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

5'-DMT-2'-OMe-U-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-U-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a uridine base. Additionally, it contains a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for various applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00410

Molecular Formula: C44H48N3O9PS2

Molecular Weight: 857.97

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: WOJBALAHZBVIKR-QBLJBMGASA-N

CanonicalSMILES: COC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C44H48N3O9PS2/c1-51-35-20-16-33(17-21-35)44(32-14-8-5-9-15-32,34-18-22-36(52-2)23-19-34)54-30-37-39(40(53-3)41(55-37)47-27-24-38(48)45-43(47)50)56-57(46-25-10-11-26-46)59-29-28-58-42(49)31-12-6-4-7-13-31/h4-9,12-24,27,37,39-41H,10-11,25-26,28-30H2,1-3H3,(H,45,48,50)/t37-,39-,40-,41-,57?/m1/s1

Synonyms: DMT-2'-OMe-U-3'-PS; [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; 2'-OMe-U-Thiophosphoramidite; 5'-Dimethoxytrityl-Uridine, 2'-O-methyl, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

5'-DMT-2'-OMe-5-Me-U-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-5-Me-U-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a 5-methyluridine base. Additionally, it features a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for various applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00411

Molecular Formula: C45H50N3O9PS2

Molecular Weight: 872.00

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: IWVGGTNZQUQJEA-MWUWPPOZSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7)OC

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C45H50N3O9PS2/c1-31-29-48(44(51)46-41(31)49)42-40(54-4)39(57-58(47-25-11-12-26-47)60-28-27-59-43(50)32-13-7-5-8-14-32)38(56-42)30-55-45(33-15-9-6-10-16-33,34-17-21-36(52-2)22-18-34)35-19-23-37(53-3)24-20-35/h5-10,13-24,29,38-40,42H,11-12,25-28,30H2,1-4H3,(H,46,49,51)/t38-,39-,40-,42-,58?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyl-uridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate

5'-DMT-2'-O-MOE-5-Me-U-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-5-Me-U-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and a 5-methyluridine base. Additionally, it contains a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for various applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00412

CAS: 2360826-70-4

Molecular Formula: C47H54N3O10PS2

Molecular Weight: 916.05

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: VCDBYBSSVSRJPT-OMRXSTERSA-N

CanonicalSMILES: O=C(SCCSP(OC1C(OC(N2C=C(C(=O)NC2=O)C)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N6CCCC6)C=7C=CC=CC7

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C47H54N3O10PS2/c1-33-31-50(46(53)48-43(33)51)44-42(57-28-27-54-2)41(60-61(49-25-11-12-26-49)63-30-29-62-45(52)34-13-7-5-8-14-34)40(59-44)32-58-47(35-15-9-6-10-16-35,36-17-21-38(55-3)22-18-36)37-19-23-39(56-4)24-20-37/h5-10,13-24,31,40-42,44H,11-12,25-30,32H2,1-4H3,(H,48,51,53)/t40-,41-,42-,44-,61?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-uridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]

5'-DMT-2'-O-MOE-U-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-U-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and a uridine base. Additionally, it contains a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for various applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00413

CAS: 2360826-71-5

Molecular Formula: C46H52N3O10PS2

Molecular Weight: 902.03

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: SDTFEZZYTOLLHY-SRYSXPHVSA-N

CanonicalSMILES: O=C(SCCSP(OC1C(OC(N2C=CC(=O)NC2=O)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N6CCCC6)C=7C=CC=CC7

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C46H52N3O10PS2/c1-53-28-29-56-42-41(59-60(48-25-10-11-26-48)62-31-30-61-44(51)33-12-6-4-7-13-33)39(58-43(42)49-27-24-40(50)47-45(49)52)32-57-46(34-14-8-5-9-15-34,35-16-20-37(54-2)21-17-35)36-18-22-38(55-3)23-19-36/h4-9,12-24,27,39,41-43H,10-11,25-26,28-32H2,1-3H3,(H,47,50,52)/t39-,41-,42-,43-,60?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyluridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]

DMT-2'-OMe-N1-Me-Pseudouridine 3'-CE phosphoramidite

Description: DMT-2'-OMe-N1-Me-Pseudouridine 3'-CE phosphoramidite is a compound utilized in nucleic acid synthesis, particularly in RNA synthesis. It comprises various functional groups including DMT (4,4'-Dimethoxytrityl) for protection, 2'-OMe for 2'-O-methylation, N1-Me for N1-methylation, and 3'-CE for 3'-cyanoethyl protection, along with a phosphoramidite moiety for incorporation into nucleotide chains.

CAT: BRP-00426

Molecular Formula: C41H51N4O9P

Molecular Weight: 744.85

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: GVNBVKSXXSEBDA-QKBNJDQWSA-N

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H51N4O9P/c1-27(2)45(28(3)4)55(52-24-12-23-42)54-37-35(53-36(38(37)50-8)34-25-44(5)40(47)43-39(34)46)26-51-41(29-13-10-9-11-14-29,30-15-19-32(48-6)20-16-30)31-17-21-33(49-7)22-18-31/h9-11,13-22,25,27-28,35-38H,12,24,26H2,1-8H3,(H,43,46,47)/t35-,36+,37-,38+,55?/m1/s1

Synonyms: 5'-DMT-2'-O-Me-N1-Me-PseudoUridine-CE-Phosphoramidite; N1-Methyl-2'-O-Methyl-5'-O-DMT-pseudoUridine 3'-CE phosphoramidite; DMT-2'-OMe-N1-Me-Pseudouridine

3'-DMT-2'-OMe-A(Bz)-CE Reverse

Description: 3'-DMT-2'-OMe-A(Bz)-CE Reverse is a specialized nucleotide compound used in oligonucleotide synthesis. It comprises a 2'-O-methyl modification and a 3'-DMT protecting group to ensure stability during synthesis. Additionally, the adenosine base is modified with a benzoyl (Bz) group. The 5'-CED phosphoramidite functionality allows for controlled addition to oligonucleotide chains, offering precision in molecular biology research for customized oligonucleotide design and synthesis.

CAT: BRP-00427

CAS: 1309448-27-8

Molecular Formula: C48H54N7O8P

Molecular Weight: 887.96

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: ZTDLWOHDFXTWBU-PSVHYZMASA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C(OC)C1OC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: ((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-methoxytetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(60-28-14-27-49)61-29-40-42(43(59-7)47(62-40)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)63-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1

Synonyms: Adenosine, N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite; 2'-O-Methyl-3'-DMT Adenosine (n-bz) 5'-CED phosphoramidite