C-TOM-CE Phosphoramidite - CAS 253586-12-8

Catalog number: BRA-052

The synthesis of RNA using monomers containing the 2'-O-Triisopropylsilyloxymethyl (TOM) group (TOM-Protecting-Group) has very high coupling efficiency along with fast, simple deprotection.

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Synonyms

5'-Dimethoxytrityl-N-acetyl-Cytidine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N-Acetyl-2'-O-[(triisopropylsilyloxy)methyl]-3'-O-[diisopropylamino(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)cytidine; (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS

253586-12-8

IUPAC Name

N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[tri(propan-2-yl)silyloxymethoxy]oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

Molecular Weight

974.22

Molecular Formula

C51H72N5O10PSi

Canonical SMILES

CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCO[Si](C(C)C)(C(C)C)C(C)C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

InChI

InChI=1S/C51H72N5O10PSi/c1-34(2)56(35(3)4)67(63-31-17-29-52)66-47-45(32-62-51(40-18-15-14-16-19-40,41-20-24-43(59-12)25-21-41)42-22-26-44(60-13)27-23-42)65-49(55-30-28-46(53-39(11)57)54-50(55)58)48(47)61-33-64-68(36(5)6,37(7)8)38(9)10/h14-16,18-28,30,34-38,45,47-49H,17,31-33H2,1-13H3,(H,53,54,57,58)/t45-,47-,48-,49-,67?/m1/s1

InChIKey

LAUSLJOCUCNMJI-RLKIZYSKSA-N

Purity

≥95%

Appearance

White to Off-white Free-flowing Powder

Storage

Store at -20°C

Chemical Structure: