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5'-O-DMT-N4-Benzoyl-3'-O-tert-butyldimethylsilyl-cytidine 2'-CE phosphoramidite
5'-O-DMT-N4-Benzoyl-3'-O-tert-butyldimethylsilyl-cytidine 2'-CE phosphoramidite, a highly acclaimed reagent in the realm of biomedicine, exhibits unparalleled significance. Notably, this phosphoramidite derivative finds widespread employment in the synthesis of altered oligonucleotides, exuding immense promise for gene therapy, drug conveyance, and diagnostic modalities.
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Catalog
BRP-02193
Synonyms
N4-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine 2'-CE phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 3'-TBDMS-Bz-rC Phosphoramidite; 3'-O-TBDMS-5'-O-DMT-N4-Bz-rC CED phosphoramidite; 5'-O-DMT-3'-TBDMS-N4-benzoyl-cytidine 2'-CE phosphoramidite
CAS
129470-47-9
IUPAC Name
N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
Molecular Weight
964.17
Molecular Formula
C52H66N5O9PSi
Canonical SMILES
CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O[Si](C)(C)C(C)(C)C
InChI
InChI=1S/C52H66N5O9PSi/c1-36(2)57(37(3)4)67(63-34-18-32-53)65-47-46(66-68(10,11)51(5,6)7)44(64-49(47)56-33-31-45(55-50(56)59)54-48(58)38-19-14-12-15-20-38)35-62-52(39-21-16-13-17-22-39,40-23-27-42(60-8)28-24-40)41-25-29-43(61-9)30-26-41/h12-17,19-31,33,36-37,44,46-47,49H,18,34-35H2,1-11H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m1/s1
InChIKey
KGHSXHZESVOJIE-YOVDOAOFSA-N
Purity
≥97% by HPLC
Chemical Structure:
