CAS 146954-75-8 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is a modified phosphoramidite designed for use in the synthesis of stable and efficient RNA and DNA oligonucleotides. Its protective groups and modifications enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in the production of antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

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Ordering Information

Catalog Number	Size	Price	Stock	Quantity
BRP-02157	5 g	$259	In stock

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Catalog

BRP-02157

Synonyms

2'-F-dU Phosphoramidite; DMT-2'Fluoro-dU Phosphoramidite; 5'-O-Dimethoxytrityl-2'-fluoro-2'-deoxyuridine 3'-CE phosphoramidite; 2'-Deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-fluorouridine 3-CE phosphoramidite; DMT-2'-Fluoro-dU amidite; 2'-Fluoro-2'-deoxy Uridine CED Phosphoramidite; 2'-Deoxy-5'-O-DMT-2'-fluorouridine 3-CE phosphoramidite; 5'-O-DMT-2'-F-dU 3'-CE phosphoramidite

CAS

146954-75-8

IUPAC Name

3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

Molecular Weight

748.78

Molecular Formula

C39H46FN4O8P

Canonical SMILES

CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

InChI

InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35-,36-,37-,53?/m1/s1

InChIKey

HQHQPAYRJJMYQX-DJTPZYMWSA-N

Purity

≥98%

Appearance

White to Off-white Powder

Storage

Store at -20 °C

Chemical Structure:

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite - CAS 146954-75-8

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite