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N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is used to incorporate 2-O-methyl modified nucleotides into oligonucleotides. It is a novel nucleoside analogue drug that inhibits tumor growth and activates RNA polymerase II promoter transcription.
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Ordering Information
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BRP-02160 | 5 g | $239 | In stock |
Catalog
BRP-02160
Synonyms
N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite; 2'-OMe-Ac-C CE phosphoramidite; N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-Cytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-2'-O-methyl-rC(Ac) amidite; 5'-O-(4,4'-Dimethoxytrityl)-N4-Acetyl-2'-O-methylcytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-2'-OMe-C(Ac)-CE-Phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-CE-phosphoramidite
CAS
199593-09-4
IUPAC Name
N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
Molecular Weight
801.86
Molecular Formula
C42H52N5O9P
Canonical SMILES
CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
InChI
InChI=1S/C42H52N5O9P/c1-28(2)47(29(3)4)57(54-26-12-24-43)56-38-36(55-40(39(38)52-8)46-25-23-37(44-30(5)48)45-41(46)49)27-53-42(31-13-10-9-11-14-31,32-15-19-34(50-6)20-16-32)33-17-21-35(51-7)22-18-33/h9-11,13-23,25,28-29,36,38-40H,12,26-27H2,1-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,57?/m1/s1
InChIKey
WNWUMIPFLOKTEZ-UAQIPLLRSA-N
Melting Point
102-104 °C
Purity
≥98% by HPLC
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance
Off-White to Light Yellow Solid
Storage
Store at -20 °C, under inert atmosphere
Chemical Structure:
