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| 500 mg | $1399 | In stock |
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Nucleosides are fundamental building blocks in DNA and RNA synthesis, serving as the chemical precursors for oligonucleotide assembly and enzymatic transcription processes. In both solid-phase oligo synthesis and enzymatic reactions, the structure, purity, and protection strategy of nucleosides have a direct impact on coupling efficiency, sequence fidelity, and overall synthesis performance. As nucleic acid technologies continue to advance, selecting high-quality nucleosides has become increasingly important for achieving reliable and reproducible results. We offer a comprehensive range of high-quality nucleosides to support DNA and RNA synthesis across diverse applications and scales.
Nucleosides consist of a nitrogenous base linked to a sugar moiety and form the core structural unit of nucleic acids. In DNA and RNA synthesis, nucleosides serve as the starting materials for the preparation of nucleotides and phosphoramidites, making them essential raw materials in both chemical and enzymatic synthesis pathways. Understanding the chemical nature of nucleosides and their functional role in synthesis workflows is critical for effective nucleic acid production.
A nucleoside is composed of a heterocyclic base—adenine, guanine, cytosine, thymine, or uracil—attached to a pentose sugar via a glycosidic bond. In DNA nucleosides, the sugar is 2'-deoxyribose, while RNA nucleosides contain ribose, which includes a hydroxyl group at the 2' position. This structural difference influences chemical reactivity, stability, and downstream synthesis strategies.
Nucleosides differ from nucleotides in that they do not contain a phosphate group. Nucleotides are formed when one or more phosphate groups are added to the nucleoside, enabling participation in enzymatic reactions such as transcription and polymerization. In chemical synthesis workflows, nucleosides are first chemically modified and protected before being converted into activated forms, such as phosphoramidites, for oligonucleotide assembly.
In solid-phase oligonucleotide synthesis, nucleosides serve as the chemical foundation for generating phosphoramidites that are sequentially coupled to form defined DNA or RNA sequences. In enzymatic processes, nucleoside-derived nucleotides are incorporated by polymerases to produce nucleic acids. Across both approaches, nucleoside quality—including purity, structural integrity, and proper protection—directly affects synthesis efficiency, sequence accuracy, and overall yield.
Our nucleoside portfolio is designed to support a wide range of DNA and RNA synthesis workflows, from routine oligonucleotide assembly to advanced nucleic acid chemistry. We supply carefully selected nucleosides with controlled purity, well-defined structures, and reliable availability, enabling consistent performance in both chemical synthesis and enzymatic applications. By offering multiple nucleoside types and modification options, we help customers select materials that align with their synthesis strategy, performance requirements, and scale.
DNA nucleosides are fundamental building blocks used in the synthesis of DNA oligonucleotides, serving as key starting materials for downstream modification and phosphoramidite preparation.
RNA nucleosides are designed to meet the specific chemical requirements of RNA synthesis, where the presence of the reactive 2'-hydroxyl group requires enhanced control over quality and handling.
Modified nucleosides are used to introduce specific chemical or functional properties into DNA and RNA oligonucleotides, enabling advanced applications beyond standard nucleic acid structures.
Protected nucleosides are chemically modified to control reactivity during oligonucleotide synthesis, enabling selective coupling and efficient assembly of defined sequences.
Nucleosides are core raw materials used across a wide range of DNA and RNA synthesis applications, providing the chemical foundation for oligonucleotide assembly and nucleic acid modification. Their structure, purity, and suitability for downstream functionalization directly influence synthesis efficiency, sequence accuracy, and overall workflow performance.
Nucleosides are essential starting materials for the routine synthesis of DNA and RNA oligonucleotides, serving as precursors for phosphoramidite preparation and chain assembly.
• Oligonucleotide synthesis: Foundation for stepwise DNA and RNA sequence construction
• Structural integrity: Well-defined nucleoside structures to ensure sequence fidelity
• Synthesis efficiency: Reliable performance in standard solid-phase workflows
• Platform compatibility: Suitable for common automated oligonucleotide synthesizers
• Reproducibility: Consistent behavior across different sequence designs
Modified nucleosides are widely used to introduce functional or chemical diversity into RNA and DNA oligonucleotides, enabling specialized properties beyond natural nucleic acids.
• Modified RNA synthesis: Support incorporation of chemically modified nucleosides
• Functional oligos: Enable enhanced stability, binding, or activity
• Custom sequence design: Facilitate tailored oligonucleotide structures
• Controlled modification: Consistent quality to ensure predictable modification outcomes
• Compatibility: Suitable for downstream conversion and assembly processes
Nucleosides play a key role in research and process development activities, where flexibility, consistency, and reliable performance are required for method optimization.
• Method development: Support optimization of synthesis and modification strategies
• Process evaluation: Enable comparison of synthesis conditions and reagents
• Scalability assessment: Suitable for transition from small-scale studies to larger workflows
• Reproducibility testing: Reliable materials for repeated experimental runs
• Workflow optimization: Compatible with evolving synthesis platforms and protocols
The quality of nucleosides is a critical factor in DNA and RNA synthesis, as it directly influences downstream modification, activation, and oligonucleotide assembly. Consistent quality standards are essential to ensure reliable chemical behavior, predictable reaction outcomes, and reproducible synthesis performance. High-quality nucleosides help minimize variability during synthesis workflows and support accurate sequence construction across research and process development applications.
Nucleosides used in nucleic acid synthesis must exhibit high chemical purity and well-defined molecular structure to perform reliably in downstream reactions. Impurities or structural deviations can interfere with protection, activation, or coupling steps, leading to reduced synthesis efficiency or inconsistent results. Maintaining strict control over purity and structural integrity ensures that nucleosides behave predictably during synthesis and support accurate DNA and RNA assembly.
For nucleosides intended for chemical modification and oligonucleotide synthesis, the stability of protecting groups is a key quality attribute. Protecting groups must remain intact under storage and handling conditions while allowing controlled removal during synthesis. Stable and well-characterized protecting groups help prevent premature side reactions, support efficient coupling, and ensure consistent performance throughout DNA and RNA synthesis workflows.
Selecting the right nucleosides is an important step in achieving reliable DNA and RNA synthesis, as material quality directly affects downstream modification, coupling efficiency, and overall workflow reproducibility. Whether you are sourcing nucleosides for routine oligonucleotide synthesis or for more specialized research and process development applications, our team can support product selection, provide detailed specifications, and assist with availability and technical questions—contact us to discuss your requirements and request further information.
Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.
Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.
Nucleosides are typically chemically modified before being used in enzymatic workflows.
Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.
High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.
