What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - RNA / BOC Sciences

5-Methylcyclocytidine hydrochlorine

Description: 5-Methylcyclocytidine hydrochlorine, a nucleoside analogue of cytidine, exhibits profound biomedical implications in combating specific ailments. Its inherent capability to impede nucleotide synthesis and viral replication positions it as a prospective anticancer and antiviral agent. However, elucidating its complete therapeutic prowess necessitates further comprehensive investigation, thus underscoring the importance of conducting extensive scientific research.

CAT: BRP-00153

CAS: 51391-96-9

Molecular Formula: C10H14ClN3O4

Molecular Weight: 275.69

Purity: ≥95%

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Storage: Store at 2-8°C

Density: 1.88±0.1 g/cm3

Boiling Point: 422.4±55.0 °C at 760 mmHg

InChIKey: NTLAKIOXMNOMIC-HSMTUSTJSA-N

CanonicalSMILES: CC1=CN2C3C(C(C(O3)CO)O)OC2=NC1=N.Cl

IUPAC Name: (2R,4R,5R,6S)-4-(hydroxymethyl)-10-imino-11-methyl-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-5-ol;hydrochloride

InChI: InChI=1S/C10H13N3O4.ClH/c1-4-2-13-9-7(6(15)5(3-14)16-9)17-10(13)12-8(4)11;/h2,5-7,9,11,14-15H,3H2,1H3;1H/t5-,6-,7+,9-;/m1./s1

Synonyms: O-2,3'-Anhydro-5-methylcytidine hydrochloride; 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-7-methyl-, monohydrochloride, [2R-(2α,3β,3aβ,9aβ)]-; (2R,3R,3aS,9aR)-2-(Hydroxymethyl)-6-imino-7-methyl-3,3a,6,9a-tetrahydro-2H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-ol Hydrochloride; CMC.HCl

Related CAS: 763867-43-2 (free base)

N4-Benzoyl-2'-O-methylcytidine

Description: N4-Benzoyl-2'-O-methylcytidine, a highly effective biomedicine, emerges as a paramount intervention for combating RNA viruses that induce viral infections. Renowned for its antiviral attributes, this groundbreaking product has garnered substantial scientific attention. Notably, its exceptional efficacy in addressing afflictions such as influenza and hepatitis has been extensively documented.

CAT: BRP-00155

CAS: 52571-45-6

Molecular Formula: C17H19N3O6

Molecular Weight: 361.35

Purity: ≥95%

Appearance: White to Pale Yellow Powder

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Storage: Store at 2-8°C

Density: 1.49±0.1 g/cm3 (Predicted)

Melting Point: 174-175°C

InChIKey: LIZIIHWLABYQKD-XKVFNRALSA-N

CanonicalSMILES: COC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)CO)O

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C17H19N3O6/c1-25-14-13(22)11(9-21)26-16(14)20-8-7-12(19-17(20)24)18-15(23)10-5-3-2-4-6-10/h2-8,11,13-14,16,21-22H,9H2,1H3,(H,18,19,23,24)/t11-,13-,14-,16-/m1/s1

Synonyms: N-Benzoyl-2'-O-methylcytidine; NSC 371910; N-(1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; N4-Bz-2'-OMe-C; 2'-OMe-C(Bz)

N2-DMF-rG

Description: N2-DMF-rG, a modified RNA nucleoside, is widely applied in the biomedical industry as a disease-targeting oligonucleotide precursor with remarkable curative potential against various viral and genetic diseases. Leveraging its high specificity and beneficial metabolism, N2-DMF-rG empowers the development of superior therapeutic oligonucleotides, fundamentally free from off-target effects, enabling stable and extended pharmacokinetics, in turn promising an efficacious disease intervention paradigm.

CAT: BRP-00156

CAS: 17331-16-7

Molecular Formula: C13H18N6O5

Molecular Weight: 338.32

Purity: ≥95% by HPLC

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Density: 1.77±0.1 g/cm3

Melting Point: 245-246 °C

Boiling Point: 708.5±70.0°C at 760 mmHg

InChIKey: WDAVDBAMSKZBEN-PZYHSTABSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)O

IUPAC Name: N'-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C13H18N6O5/c1-18(2)4-15-13-16-10-7(11(23)17-13)14-5-19(10)12-9(22)8(21)6(3-20)24-12/h4-6,8-9,12,20-22H,3H2,1-2H3,(H,16,17,23)/b15-4+/t6-,8-,9-,12-/m1/s1

Synonyms: N'-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide; Formamidine, N'-(1,6-dihydro-6-oxo-9-β-D-ribofuranosyl-9H-purin-2-yl)-N,N-dimethyl-; N-[(Dimethylamino)methylene]guanosine; rG(dmf); N2-Dimethylaminomethylene-rG

N4-Benzoylcytidine

Description: A useful building block for oligoribonucleotide synthesis.

CAT: BRP-00157

CAS: 13089-48-0

Molecular Formula: C16H17N3O6

Molecular Weight: 347.32

Purity: ≥97% by HPLC

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

Density: 1.59 g/cm3

Melting Point: 218-221°C

InChIKey: BNXBRFDWSPXODM-BPGGGUHBSA-N

Solubility: Soluble in DMSO, Methanol

CanonicalSMILES: C1=CC=C(C=C1)C(=O)NC2=NC(=O)N(C=C2)C3C(C(C(O3)CO)O)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C16H17N3O6/c20-8-10-12(21)13(22)15(25-10)19-7-6-11(18-16(19)24)17-14(23)9-4-2-1-3-5-9/h1-7,10,12-13,15,20-22H,8H2,(H,17,18,23,24)/t10-,12-,13-,15-/m1/s1

Synonyms: N-Benzoylcytidine; N-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; 4-N-benzoyl cytidine; N6-Benzoylcytidine; NSC 242979; ribo Cytidine (n-bz)

N4-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine

Description: N4-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine, an influential therapeutic agent, stands as a formidable solution for combating viral infections such as hepatitis C and HIV. By harmoniously intertwining the antiviral attributes of cytidine with the defensive capabilities endowed by tert-butyldimethylsilyl and DMT groups, this compound markedly amplifies drug sturdiness and effectiveness.

CAT: BRP-00158

CAS: 81246-78-8

Molecular Formula: C43H49N3O8Si

Molecular Weight: 763.95

Purity: ≥98% by HPLC

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Density: 1.19±0.1 g/cm3 at 20°C

InChIKey: ADAGVSVPBZZOKW-PKGPUZNISA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(OC(C1O)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C43H49N3O8Si/c1-42(2,3)55(6,7)54-38-35(53-40(37(38)47)46-27-26-36(45-41(46)49)44-39(48)29-14-10-8-11-15-29)28-52-43(30-16-12-9-13-17-30,31-18-22-33(50-4)23-19-31)32-20-24-34(51-5)25-21-32/h8-27,35,37-38,40,47H,28H2,1-7H3,(H,44,45,48,49)/t35-,37-,38-,40-/m1/s1

Synonyms: 5'-DMT-3'-tBDSilyl Cytidine (n-bz); 5'-DMT-3'-TBDMS-Bz-rC; N4-Benzyl-3'-O-t-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)cytidine; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-Cytidine; N4-Bz-5'-O-DMT-3'-O-TBDMS-cytidine

3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine

Description: It is used for special nucleoside or RNA modification.

CAT: BRP-00159

CAS: 81246-81-3

Molecular Formula: C36H44N2O8Si

Molecular Weight: 660.83

Purity: ≥95%

Appearance: White Solid

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Density: 1.3±0.1 g/cm3

InChIKey: ZATGYRPVDYINRF-WXQJYUTRSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(OC(C1O)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-hydroxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C36H44N2O8Si/c1-35(2,3)47(6,7)46-32-29(45-33(31(32)40)38-22-21-30(39)37-34(38)41)23-44-36(24-11-9-8-10-12-24,25-13-17-27(42-4)18-14-25)26-15-19-28(43-5)20-16-26/h8-22,29,31-33,40H,23H2,1-7H3,(H,37,39,41)/t29-,31-,32-,33-/m1/s1

Synonyms: 5'-DMT-3'-tBDSilyl Uridine; 5'-O-DMT-3'-O-TBDMS uridine; 5'-O-(4,4'-Dimethoxytrityl)-3'-O-t-butyldimethylsilyl uridine; 3'-O-(tert-Butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)uridine; 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]uridine; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine

3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine

Description: 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine, an imperative compound employed in the field of biomedicine, exhibits noteworthy significance in the process of synthesizing nucleic acids for genetic investigations. Through the modification of nucleotides, this compound facilitates precise administration of therapeutic drugs and gene therapy. Expanding its utility, it finds applications in addressing a myriad of ailments including cancer, viral infections, and genetic disorders, thereby serving as an indispensable instrument in the realm of biomedical research.

CAT: BRP-00160

CAS: 81256-89-5

Molecular Formula: C41H51N5O8Si

Molecular Weight: 769.96

Purity: 97%

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Density: 1.25±0.1 g/cm3(Predicted)

InChIKey: XAIQBZNFPUNWMQ-CJEGOSRCSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O[Si](C)(C)C(C)(C)C)O

IUPAC Name: N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C41H51N5O8Si/c1-25(2)36(48)44-39-43-35-32(37(49)45-39)42-24-46(35)38-33(47)34(54-55(8,9)40(3,4)5)31(53-38)23-52-41(26-13-11-10-12-14-26,27-15-19-29(50-6)20-16-27)28-17-21-30(51-7)22-18-28/h10-22,24-25,31,33-34,38,47H,23H2,1-9H3,(H2,43,44,45,48,49)/t31-,33-,34-,38-/m1/s1

Synonyms: 5'-DMT-3'-tBDSilyl Guanosine (n-ibu); 5'-DMT-3'-TBDMS-ibu-rG; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine

N4-Acetyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine

Description: N4-Acetyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine is a cutting-edge and technologically advanced biomedical compound aiding in studying an extensive array of debilitating diseases.

CAT: BRP-00161

CAS: 123956-65-0

Molecular Formula: C38H47N3O8Si

Molecular Weight: 701.88

Purity: 98%

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Storage: Store at 2-8°C

Density: 1.19±0.1 g/cm3 (Predicted)

InChIKey: RWIUJRXXJFJUFX-HYGOWAQNSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[Si](C)(C)C(C)(C)C)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C38H47N3O8Si/c1-25(42)39-32-22-23-41(36(44)40-32)35-33(43)34(49-50(7,8)37(2,3)4)31(48-35)24-47-38(26-12-10-9-11-13-26,27-14-18-29(45-5)19-15-27)28-16-20-30(46-6)21-17-28/h9-23,31,33-35,43H,24H2,1-8H3,(H,39,40,42,44)/t31-,33-,34-,35-/m1/s1

Synonyms: 5'-DMT-3'-TBDMS-Ac-rC; N-(1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide; 3'-O-t-Butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-N4-acetyl cytidine; 3'-O-TBDMS-5'-O-DMT-N4-Ac cytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]cytidine; 5'-DMT-3'-TBDMS-C(Ac)

N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine

Description: It is used for nucleoside modification, amidite and nucleic acid synthesis.

CAT: BRP-00162

CAS: 81256-88-4

Molecular Formula: C44H49N5O7Si

Molecular Weight: 787.97

Purity: 96%

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

Density: 1.2±0.1 g/cm3

InChIKey: QNPRMZLAAWKAPQ-GNECSJIWSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(OC(C1O)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-hydroxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C44H49N5O7Si/c1-43(2,3)57(6,7)56-38-35(55-42(37(38)50)49-28-47-36-39(45-27-46-40(36)49)48-41(51)29-14-10-8-11-15-29)26-54-44(30-16-12-9-13-17-30,31-18-22-33(52-4)23-19-31)32-20-24-34(53-5)25-21-32/h8-25,27-28,35,37-38,42,50H,26H2,1-7H3,(H,45,46,48,51)/t35-,37-,38-,42-/m1/s1

Synonyms: 5'-DMT-3'-tBDSilyl Adenosine (n-bz); N6-benzoyl-5'-O-DMT-3'-O-TBDMS-adenosine; N6-benzoyl-3'-O-t-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-adenosine; 5'-DMT-3'-TBDMS-Bz-rA; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[dimethyl(2-methyl-2-propanyl)silyl]adenosine

5'-O-DMT-2'-O-methyl-5-methyluridine

Description: 5'-O-DMT-2'-O-methyl-5-methyluridine is a modified nucleoside molecule that contains a 5'-O-dimethoxytrityl (DMT) group on the 5' carbon, a 2'-O-methyl group on the 2' carbon, and a methyl group on the 5th carbon of the uracil base. This modification is commonly used in nucleic acid synthesis and research to protect and manipulate nucleosides for various applications.

CAT: BRP-00163

CAS: 153631-19-7

Molecular Formula: C32H34N2O8

Molecular Weight: 574.62

Purity: ≥97% by HPLC

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Density: 1.33±0.1 g/cm3 (Predicted)

InChIKey: VFLOXJCZWDDILQ-NODMTMHWSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OC

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C32H34N2O8/c1-20-18-34(31(37)33-29(20)36)30-28(40-4)27(35)26(42-30)19-41-32(21-8-6-5-7-9-21,22-10-14-24(38-2)15-11-22)23-12-16-25(39-3)17-13-23/h5-18,26-28,30,35H,19H2,1-4H3,(H,33,36,37)/t26-,27-,28-,30-/m1/s1

Synonyms: 5'-DMT-5-Me-2'-OMe-U; DMT-5-Me-2'-OMe-U; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-methyl-; 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-methyl-Uridine; 5'-O-(Dimethoxytrityl)-2'-O-methyl-5-methyluridine; 5-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine

N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine

Description: N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine is a valuable compound extensively used in the biomedical industry acting as a key intermediate for the synthesis of nucleotides and nucleosides. This product finds application in the development of antiviral drugs targeting various diseases caused by viral infections.

CAT: BRP-00165

CAS: 81256-87-3

Molecular Formula: C43H49N3O8Si

Molecular Weight: 763.95

Purity: ≥98% by HPLC

Appearance: White to Light Yellow Powder to Crystalline Powder

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Storage: Store at -20°C

Density: 1.2±0.1 g/cm3

InChIKey: AOXWVTIMEGOVNF-PKGPUZNISA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C43H49N3O8Si/c1-42(2,3)55(6,7)54-38-37(47)35(53-40(38)46-27-26-36(45-41(46)49)44-39(48)29-14-10-8-11-15-29)28-52-43(30-16-12-9-13-17-30,31-18-22-33(50-4)23-19-31)32-20-24-34(51-5)25-21-32/h8-27,35,37-38,40,47H,28H2,1-7H3,(H,44,45,48,49)/t35-,37-,38-,40-/m1/s1

Synonyms: 5'-DMT-2'-tBDSilyl Cytidine (n-bz); 5'-DMT-2'-TBDMS-Bz-rC; 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine; N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N-benzoylcytidine; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[tert-butyl(dimethyl)silyl]cytidine; N4-Benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)cytidine

5'-O-DMT-N2-DMF-guanosine

Description: 5'-O-DMT-N2-DMF-guanosine, a remarkably powerful nucleoside analog, assumes a crucial role in the realm of biomedicine in combatting select malignancies. Its extraordinary molecular architecture endows it with the ability to impede the proliferation of neoplastic cells via targeted interference with distinct signaling cascades. By virtue of this distinct attribute, this compound holds potential for augmented therapeutic efficacy and mitigated untoward ramifications when used concomitantly with other chemotherapeutic agents.

CAT: BRP-00166

CAS: 126922-60-9

Molecular Formula: C34H36N6O7

Molecular Weight: 640.69

Purity: ≥98% by HPLC

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Density: 1.4±0.1 g/cm3

InChIKey: FWBIVABFLXJWQH-NXKHUQPWSA-N

CanonicalSMILES: CN(C)C=NC1=NC(=O)C2C(=N1)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)O

IUPAC Name: N'-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-6-oxo-5H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C34H36N6O7/c1-39(2)19-36-33-37-30-27(31(43)38-33)35-20-40(30)32-29(42)28(41)26(47-32)18-46-34(21-8-6-5-7-9-21,22-10-14-24(44-3)15-11-22)23-12-16-25(45-4)17-13-23/h5-17,19-20,26-29,32,41-42H,18H2,1-4H3/b36-19+/t26-,27?,28-,29-,32-/m1/s1

Synonyms: 5'-DMT-DMF-rG; 5'-O-(4,4'-Dimethoxytrityl)-N2-DMF-Guanosine; 5'-O-DMT-N2-DMF-rG; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-N-[(dimethylamino)methylene]guanosine; N'-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide; 5'-O-DMT-G(DMF)

N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]cytidine

Description: N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]cytidine is a chemical compound used in the synthesis of oligonucleotides. This compound features a cytidine nucleoside that has been modified with a benzoyl (bz) group protecting the amino group at the N4 position and a bis(4-methoxyphenyl)phenylmethyl (commonly known as dimethoxytrityl or DMT) group protecting the 5' hydroxyl position. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is essential for various applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-00167

CAS: 81246-76-6

Molecular Formula: C37H35N3O8

Molecular Weight: 649.69

Purity: ≥95%

Appearance: Yellow Solid

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Storage: Store at -20°C

Density: 1.3±0.1 g/cm3

Melting Point: 132-135°C

InChIKey: KCLOEKUQZJAMFG-NHASGABXSA-N

Solubility: Soluble in Chloroform, Dichloromethane, DMSO, Methanol

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)O)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C37H35N3O8/c1-45-28-17-13-26(14-18-28)37(25-11-7-4-8-12-25,27-15-19-29(46-2)20-16-27)47-23-30-32(41)33(42)35(48-30)40-22-21-31(39-36(40)44)38-34(43)24-9-5-3-6-10-24/h3-22,30,32-33,35,41-42H,23H2,1-2H3,(H,38,39,43,44)/t30-,32-,33-,35-/m1/s1

Synonyms: 5'-DMT Cytidine (n-bz); 5'-O-(4,4'-Dimethoxytrityl)-N4-benzoylcytidine; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-; N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)cytidine; N4-Benzoyl-5'-O-DMT-D-cytidine; N-Benzoyl-5'-(di-p-methoxytrityl)cytidine

5'-O-DMT-inosine

Description: 5'-O-DMT-inosine is also known as 5'-O-dimethoxytrityl inosine, beholding immense significance primarily in the realm of nucleotide and nucleoside research. Notably, its profound properties have positioned it as a crucial catalyst in the intricate process of formulating cutting-edge antiviral medications .

CAT: BRP-00168

CAS: 119898-59-8

Molecular Formula: C31H30N4O7

Molecular Weight: 570.59

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at -20 °C

Density: 1.4±0.1 g/cm3

Boiling Point: 833.3±75.0°C at 760 mmHg

InChIKey: PQXVLEMIGAJLIN-BQOYKFDPSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=NC6=C5N=CNC6=O)O)O

IUPAC Name: 9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-1H-purin-6-one

InChI: InChI=1S/C31H30N4O7/c1-39-22-12-8-20(9-13-22)31(19-6-4-3-5-7-19,21-10-14-23(40-2)15-11-21)41-16-24-26(36)27(37)30(42-24)35-18-34-25-28(35)32-17-33-29(25)38/h3-15,17-18,24,26-27,30,36-37H,16H2,1-2H3,(H,32,33,38)/t24-,26-,27-,30-/m1/s1

Synonyms: 5'-O-DMTr-Inosine; 5'-DMT-rI; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]inosine; 9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 5'-O-(4,4'-Dimethoxytrityl)inosine

N4-Acetyl-5'-O-DMT-cytidine

Description: N4-Acetyl-5'-O-DMT-cytidine is a prominent biochemical compound with antiviral properties, used for studying an array of viral afflictions. Its potency lies in its remarkable ability to impede the replication of distinct viral strains.

CAT: BRP-00170

CAS: 121058-82-0

Molecular Formula: C32H33N3O8

Molecular Weight: 587.63

Purity: 98%

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

Density: 1.32±0.1 g/cm3 (Predicted)

InChIKey: AFQGZOMSSIQDMD-PYYPWFDZSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C32H33N3O8/c1-20(36)33-27-17-18-35(31(39)34-27)30-29(38)28(37)26(43-30)19-42-32(21-7-5-4-6-8-21,22-9-13-24(40-2)14-10-22)23-11-15-25(41-3)16-12-23/h4-18,26,28-30,37-38H,19H2,1-3H3,(H,33,34,36,39)/t26-,28-,29-,30-/m1/s1

Synonyms: 5'-DMT Cytidine (n-acetyl); 5'-DMT-Ac-rC; N-Acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]cytidine; 5'-O-(4,4'-Dimethoxytrityl)-N4-acetylcytidine; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)cytidine; N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

N6-Benzoyl-5'-O-DMT-adenosine

Description: N6-Benzoyl-5'-O-DMT-adenosine is an indispensable compound, serving multifarious applications in studying ailments such as cancer and neurodegenerative disorder.

CAT: BRP-00171

CAS: 81246-82-4

Molecular Formula: C38H35N5O7

Molecular Weight: 673.71

Purity: ≥95%

Appearance: White to Off-white Crystalline Powder

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Storage: Store at 2-8°C

Density: 1.36±0.1 g/cm3

InChIKey: QPHBEJADZCSKCY-GONXPTGJSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)NC(=O)C7=CC=CC=C7)O)O

IUPAC Name: N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C38H35N5O7/c1-47-28-17-13-26(14-18-28)38(25-11-7-4-8-12-25,27-15-19-29(48-2)20-16-27)49-21-30-32(44)33(45)37(50-30)43-23-41-31-34(39-22-40-35(31)43)42-36(46)24-9-5-3-6-10-24/h3-20,22-23,30,32-33,37,44-45H,21H2,1-2H3,(H,39,40,42,46)/t30-,32-,33-,37-/m1/s1

Synonyms: 5'-DMT Adenosine (n-bz); 5'-O-DMT-N6-Bz Adenosine; N6-Benzoyl-5'-O-DMT-D-adenosine; 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl adenosine; 5'-DMT-Bz-rA; 5'-O-DMTr-N6-benzoyladenosine; N-benzoyl-5'-0-[bis(4-methoxyphenyl]phenylmethyl]adenosine; 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N6-benzoyladenosine

2'-Deoxy-5'-O-DMT-uridine

Description: 2'-Deoxy-5'-O-DMT-uridine, an esteemed compound employed in biomedicine, holds immense value. It finds frequent application in pharmaceutical research, specifically in designing antiviral drugs that combat RNA-based viruses.

CAT: BRP-00172

CAS: 23669-79-6

Molecular Formula: C30H30N2O7

Molecular Weight: 530.57

Purity: ≥98% by HPLC

Appearance: White to Pale Yellow Crystalline Powder

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Storage: Store at -20°C

Density: 1.294±0.06 g/cm3

Melting Point: 120 °C

InChIKey: BYGKUWPLEGHFKX-ZRRKCSAHSA-N

Solubility: Soluble in Acetonitrile (20 mg/mL)

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(CC(O4)N5C=CC(=O)NC5=O)O

IUPAC Name: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C30H30N2O7/c1-36-23-12-8-21(9-13-23)30(20-6-4-3-5-7-20,22-10-14-24(37-2)15-11-22)38-19-26-25(33)18-28(39-26)32-17-16-27(34)31-29(32)35/h3-17,25-26,28,33H,18-19H2,1-2H3,(H,31,34,35)/t25-,26+,28+/m0/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine; 5'-O-DMT-dU; 2'-Deoxy-5'-O-DMT-D-uridine; 5'-O-DMT-2'-deoxyuridine; 5'-O-(Bis(4-methoxyphenyl)benzyl)-2'-deoxyuridine; 1-[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxyoxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)uridine; 5'-O-[α,α-bis(p-methoxyphenyl)benzyl]-2'-deoxy-Uridine

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-deoxyuridine

Description: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-deoxyuridine is a modified deoxyuridine nucleoside used in oligonucleotide synthesis. It contains a 1,1,3,3-tetraisopropyl-1,3-disiloxane linker connecting the 3' and 5' positions of the sugar moiety, thereby protecting it. This modification helps ensure stability during synthesis. As a result, precise and efficient oligonucleotide assembly can be achieved for various molecular biology and biotechnology applications.

CAT: BRP-00173

CAS: 98495-56-8

Molecular Formula: C21H38N2O6Si2

Molecular Weight: 470.72

Purity: ≥97%

Appearance: White to off-white powder

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Density: 1.12±0.1 g/cm3

InChIKey: PEDMJTBGYAMVDO-NLWGTHIKSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(CC(O2)N3C=CC(=O)NC3=O)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: 1-[(6aR,8R,9aS)-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C21H38N2O6Si2/c1-13(2)30(14(3)4)26-12-18-17(28-31(29-30,15(5)6)16(7)8)11-20(27-18)23-10-9-19(24)22-21(23)25/h9-10,13-18,20H,11-12H2,1-8H3,(H,22,24,25)/t17-,18+,20+/m0/s1

Synonyms: 2'-Deoxy-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)uridine; 2'-Deoxy-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]uridine; 5',3'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine; 2'-Deoxy-3',5'-TIPDS-Ur; 3',5'-TIPS-2'-dU

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-5-methyluridine

Description: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-5-methyluridine, a remarkably powerful biomedicine, is harnessed in the treatment of an array of afflictions. Unearthed on diverse biomedical platforms, this compound unfurls unparalleled therapeutic potential in vanquishing cancer, combating viral infections, and mitigating genetic disorders. Its profound mechanism revolves around meticulously targeting and steering distinct cellular pathways, paving the way for gene expression modulation, viral replication inhibition, and impeding tumor proliferation.

CAT: BRP-00174

CAS: 130983-87-8

Molecular Formula: C22H40N2O7Si2

Molecular Weight: 500.73

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

Density: 1.16±0.1 g/cm3

InChIKey: FXSUFWJWZYCZNU-ANTGDGSKSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C3C(O2)CO[Si](O[Si](O3)(C(C)C)C(C)C)(C(C)C)C(C)C)O

IUPAC Name: 1-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C22H40N2O7Si2/c1-12(2)32(13(3)4)28-11-17-19(30-33(31-32,14(5)6)15(7)8)18(25)21(29-17)24-10-16(9)20(26)23-22(24)27/h10,12-15,17-19,21,25H,11H2,1-9H3,(H,23,26,27)/t17-,18-,19-,21-/m1/s1

Synonyms: 3',5'-TIPS-5-Me Uridine; 3',5'-TIPS-5-methyluridine; 5-Methyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]uridine; 3',5'-O-(Tetraisopropyldisiloxanediyl)-5-methyluridine; 3',5'-TIPDS-5-Me-Ur; 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-5-methyl-uridine

N4-Acetyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine

Description: N4-Acetyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine, a remarkable biomedical entity, exhibits profound efficacy in addressing specific ailments and pathologies. In the realm of biomedicine, this compound has garnered immense attention owing to its auspicious implications in the synthesis of antiviral agents and nucleoside analogs targeting diverse viral afflictions.

CAT: BRP-00175

CAS: 85335-73-5

Molecular Formula: C23H41N3O7Si2

Molecular Weight: 527.76

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

Density: 1.24±0.1 g/cm3

InChIKey: DQGHXFWTOQROJQ-ZHHKINOHSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)N3C=CC(=NC3=O)NC(=O)C)O)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: N-[1-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C23H41N3O7Si2/c1-13(2)34(14(3)4)30-12-18-21(32-35(33-34,15(5)6)16(7)8)20(28)22(31-18)26-11-10-19(24-17(9)27)25-23(26)29/h10-11,13-16,18,20-22,28H,12H2,1-9H3,(H,24,25,27,29)/t18-,20-,21-,22-/m1/s1

Synonyms: 3',5'-O-TIPPS-N4-acetylcytidine; N4-Acetyl-3',5'-O-TIPPS-cytidine; N-Acetyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]cytidine; N4-Acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine; 3',5'-TIPS-N-Ac-Cytidine