What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - RNA / BOC Sciences

2'-O-Methyl-5-methylcytidine

Description: 2'-O-Methyl-5-methylcytidine is a biomedical compound unveiling powerful antiviral potential. It can effectively thwart their nefarious RNA enhancement machinery, thus abruptly halting their audacious replication endeavors.

CAT: BRP-00013

CAS: 113886-70-7

Molecular Formula: C11H17N3O5

Molecular Weight: 271.27

Purity: ≥95%

Appearance: White to Off-white Crystalline Powder

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Storage: Store at 2-8°C

Density: 1.61±0.1 g/cm3(Predicted)

Melting Point: 235-238°C

Boiling Point: 504.6±60.0 °C(Predicted)

Symbol: m⁵Cm

InChIKey: CNVRVGAACYEOQI-FDDDBJFASA-N

Solubility: Soluble in DMSO (Slightly), Water (Slightly, Sonicated)

CanonicalSMILES: CC1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)OC

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-5-methylpyrimidin-2-one

InChI: InChI=1S/C11H17N3O5/c1-5-3-14(11(17)13-9(5)12)10-8(18-2)7(16)6(4-15)19-10/h3,6-8,10,15-16H,4H2,1-2H3,(H2,12,13,17)/t6-,7-,8-,10-/m1/s1

Synonyms: 2'-(O-Methyl)-5-Methyl Cytidine; 5,2'-O-dimethylcytidine; Cytidine, 5-methyl-2'-O-methyl-; 5-methyl-2'-O-methylcytidine; 4-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one

5-Iodotubercidin

Description: It is an adenosine kinase inhibitor, protein kinase inhibitor and activator, nucleoside transporter inhibitor.

CAT: BRP-00017

CAS: 24386-93-4

Molecular Formula: C11H13IN4O4

Molecular Weight: 392.15

Purity: ≥95%

Appearance: Off-white to Light Brown Solid

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Storage: Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -113°C for long term (months to years).

Density: 2.49 g/cm3

Melting Point: 216-217°C (dec.)

Boiling Point: 701.5±60.0 °C | Condition: Press: 760 Torr

Application: An analogue of the antibiotic tubercidin, a pyrrolo[2,3-d]pyrimidine nucleoside antibiotic. A potent inhibitor of adenosine kinase from rat or guinea pig brain. Inhibits uptake of 3H-adenosine into brain slices.

Shelf Life: 2 years

InChIKey: WHSIXKUPQCKWBY-IOSLPCCCSA-N

Solubility: Soluble in DMSO (Slightly), Methanol (Slightly, Heated)

CanonicalSMILES: C1=C(C2=C(N1C3C(C(C(O3)CO)O)O)N=CN=C2N)I

IUPAC Name: (2R,3R,4S,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol

InChI: InChI=1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1

Synonyms: 7-Iodo-tubercidin; 7-Deaza-7-iodoadenosine; 4-Amino-5-iodo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine; NSC 113939; 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 7-iodo-7-deazaadenosine; 7-deaza-7-I-Ar

5-Iodocytidine

Description: 5-Iodocytidine is an intermediate for research in the field of nucleic acids and nucleic acid-protein interactions.

CAT: BRP-00019

CAS: 1147-23-5

Molecular Formula: C9H12IN3O5

Molecular Weight: 369.11

Purity: ≥95%

Appearance: White solid

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Storage: Store at -20 °C

Density: 2.52±0.1 g/cm³ (Predicted)

Melting Point: >160 °C (dec.)

Boiling Point: 565.5±60.0 °C at 760 mmHg

InChIKey: LQQGJDJXUSAEMZ-UAKXSSHOSA-N

Solubility: Soluble in DMSO (Slightly), Methanol (Slightly), Water (Slightly)

CanonicalSMILES: C1=C(C(=NC(=O)N1C2C(C(C(O2)CO)O)O)N)I

IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one

InChI: InChI=1S/C9H12IN3O5/c10-3-1-13(9(17)12-7(3)11)8-6(16)5(15)4(2-14)18-8/h1,4-6,8,14-16H,2H2,(H2,11,12,17)/t4-,5-,6-,8-/m1/s1

Synonyms: 1-β-D-Ribofuranosyl-5-iodocytosine; 5-Iodo-cytidine; 4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one; 5-Iodo-ribo Cytidine

5-Iodouridine

Description: It is a Rho-GTPase cell protein inhibitor.

CAT: BRP-00020

CAS: 1024-99-3

Molecular Formula: C9H11IN2O6

Molecular Weight: 370.10

Purity: ≥95%

Appearance: White Powder

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Storage: Store at 2-8°C

Density: 2.27±0.1 g/cm3 (Predicted)

Melting Point: 205-207°C (dec.)

InChIKey: RKSLVDIXBGWPIS-UAKXSSHOSA-N

Solubility: Soluble in Water

CanonicalSMILES: C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)O)I

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione

InChI: InChI=1S/C9H11IN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1

Synonyms: NSC 523375; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione; 2,4-Dihydroxy-5-iodo-1-β-D-ribofuranosylpyrimidine; 5-Iodo-1-(β-D-ribofuranosyl)uracil; 5-Iodo Uridine

Adenosine

Description: Adenosine is a purine nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.

CAT: BRP-00021

CAS: 58-61-7

Molecular Formula: C10H13N5O4

Molecular Weight: 267.24

Purity: ≥95% by HPLC

Appearance: white crystalline powder

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Storage: Store at 2-8°C

Density: 2.08 g/cm3

Melting Point: 234-236°C

Boiling Point: 676.3°C at 760 mmHg

Application: neuromodulator

InChIKey: OIRDTQYFTABQOQ-KQYNXXCUSA-N

Solubility: Soluble in water

CanonicalSMILES: C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CO)O)O

IUPAC Name: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

InChI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

Synonyms: Adenocard; Adenoscan; Adenine riboside; ribo Adenosine; rA; 9-β-D-Ribofuranosyl-9H-purin-6-amine; 9-β-D-Ribofuranosyladenine; D-Adenosine; Boniton; Myocol; NQZ-012; NSC 7652; Nucleocardyl; Riboadenosine; Sandesin; β-D-Adenosine; β-D-Ribofuranoside, adenine-9; β-Adenosine

Uridine

Description: Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

CAT: BRP-00038

CAS: 58-96-8

Molecular Formula: C9H12N2O6

Molecular Weight: 244.20

Purity: ≥98% by HPLC

Appearance: White crystalline powder

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Storage: Store at 2-8 °C

Density: 1.674±0.06 g/cm3

Melting Point: 165 °C

Boiling Point: 387.12°C (rough estimate)

InChIKey: DRTQHJPVMGBUCF-XVFCMESISA-N

Solubility: Soluble in Dimethylsulfoxide, Methanol, Water (50 mg/mL)

CanonicalSMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

Synonyms: Cytarabine Impurity B; 1-β-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione; 1-β-D-Ribofuranosyluracil; NSC 20256; Uracil riboside; 1-β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione; Uridin; β-Uridine; Cytarabine EP Impurity B

N2-iso-Butyroyl-2'-O-(2-methoxyethyl)guanosine

Description: N2-iso-Butyroyl-2'-O-(2-methoxyethyl)guanosine, a remarkable biomedical compound renowned for its exceptional antiviral attributes, is indeed a profound breakthrough in the field. With its unrivaled inhibitory prowess against viral replication, this marvel exhibits immense promise in combatting treacherous RNA viruses, namely hepatitis C and dengue fever. Its captivating mode of operation revolves around perturbing viral RNA synthesis, thereby positioning itself as an invaluable contender within the realm of antiviral therapeutics.

CAT: BRP-00055

CAS: 440327-50-4

Molecular Formula: C17H25N5O7

Molecular Weight: 411.41

Purity: ≥95%

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20°C

Shelf Life: 2 years

InChIKey: IZOOGJIUOCHAAY-UBEDBUPSSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)OCCOC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C17H25N5O7/c1-8(2)14(25)20-17-19-13-10(15(26)21-17)18-7-22(13)16-12(28-5-4-27-3)11(24)9(6-23)29-16/h7-9,11-12,16,23-24H,4-6H2,1-3H3,(H2,19,20,21,25,26)/t9-,11-,12-,16-/m1/s1

Synonyms: N-(9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; Guanosine, 2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-; 2'-O-MOE-N2-ibu-rG; N2-isobutyryl-2-O-(2-methoxyethyl)guanosine; N2-iBu-2'-O-MOE-G; N2-isobutyryl-2'-O-methoxyethyl-guanosine

4'-alpha-Azidouridine

Description: 4'-alpha-Azidouridine, a biomedical compound, assumes paramount significance in the realm of antiviral therapy. Its applications predominantly revolve around combating viral infections instigated by RNA viruses. By selectively and adeptly impeding viral replication and transcription, this compound emerges as an efficacious weapon against afflictions like influenza, hepatitis C, and HIV.

CAT: BRP-00056

CAS: 139442-01-6

Molecular Formula: C9H11N5O6

Molecular Weight: 285.21

Purity: ≥95%

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InChIKey: FHPJZSIIXUQGQE-JVZYCSMKSA-N

CanonicalSMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O

IUPAC Name: 1-[(2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C9H11N5O6/c10-13-12-9(3-15)6(18)5(17)7(20-9)14-2-1-4(16)11-8(14)19/h1-2,5-7,15,17-18H,3H2,(H,11,16,19)/t5-,6+,7-,9-/m1/s1

Synonyms: 1-(4'-Azido-beta-D-ribofuranosyl)uracil; 4'-azidouridine; Uridine, 4-C-azido-; 1-[(2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 4'-C-azidouridine

2'-C-methyladenosine

Description: 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 µM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 µM.

CAT: BRP-00057

CAS: 15397-12-3

Molecular Formula: C11H15N5O4

Molecular Weight: 281.27

Purity: ≥95%

Appearance: Solid

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Storage: 4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Density: 1.89±0.1 g/cm3

Boiling Point: 643.4±65.0 °C at 760 mmHg

InChIKey: PASOFFRBGIVJET-YRKGHMEHSA-N

Solubility: Soluble in DMF, DMSO, PBS

CanonicalSMILES: OC[C@@H]1[C@@H](O)[C@@](C)(O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1

IUPAC Name: (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol

InChI: InChI=1S/C11H15N5O4/c1-11(19)7(18)5(2-17)20-10(11)16-4-15-6-8(12)13-3-14-9(6)16/h3-5,7,10,17-19H,2H2,1H3,(H2,12,13,14)/t5-,7-,10-,11-/m1/s1

Synonyms: 2'-C-methyladenosine;15397-12-3;(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol;2'-methyl-adenosine;2-C-methyl adenosine;(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol;CHEMBL73809;2''-C-methyladenosine;2/'-C-Methyladenosine;(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol;2-c-methyladenosine;2''-methyl-adenosine;2'-C-Methyl-adenosine;2'-C-Methyl Adenosine;Beta-2'-Methyladenosine;beta-2''-Methyladenosine;2'-C-MeA;SCHEMBL382543;2'-C-Me-A;DTXSID90333334;PASOFFRBGIVJET-YRKGHMEHSA-N;2'-C-CH3-A;BCX-4026;BDBM50144948;MFCD02682944;AKOS015914550;BS-25234;DA-49398;PD077382;F12904;(3R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol;(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol;(2R,3R,4R,5R)-5-Hydroxymethyl-3-methyl-2-(6-methylamino-purin-9-yl)-tetrahydro-furan-3,4-diol;

2-C-methyl-6-O-methyl-guanosine

Description: 2-C-methyl-6-O-methyl-guanosine - an exalted nucleoside analog flourishing in the realm of biomedical applications. As a prodigious antiviral agent, its dominion extends to combating the perils inflicted by RNA viruses like hepatitis C and respiratory syncytial virus (RSV). Proficiently curbing viral replication and subduing the viral life cycle, it has garnered reverence among scientific circles. Moreover, its boundless panorama of therapeutic possibilities in countering diverse viral afflictions continues to enthrall researchers worldwide. Beware, for this extraordinary entity is unrivaled in its prowess.

CAT: BRP-00058

CAS: 714249-80-6

Molecular Formula: C12H17N5O5

Molecular Weight: 311.29

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Density: 1.8±0.1 g/cm3

Boiling Point: 690.2±65.0 °C(Predicted)

InChIKey: OAIGYKVLSKBAJZ-GSWPYSDESA-N

CanonicalSMILES: CC1(C(C(OC1N2C=NC3=C2N=C(N=C3OC)N)CO)O)O

IUPAC Name: (2R,3R,4R,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol

InChI: InChI=1S/C12H17N5O5/c1-12(20)7(19)5(3-18)22-10(12)17-4-14-6-8(17)15-11(13)16-9(6)21-2/h4-5,7,10,18-20H,3H2,1-2H3,(H2,13,15,16)/t5-,7-,10-,12-/m1/s1

Synonyms: (2R,3R,4R,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol; 2'-C-Methyl-6-O-methyl-guanosine; INX 08144

2'-C-Methylcytidine

Description: A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication.

CAT: BRP-00059

CAS: 20724-73-6

Molecular Formula: C10H15N3O5

Molecular Weight: 257.24

Purity: ≥95%

Appearance: white to off-white powder

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Storage: Store in a cool and dry place and at 2-8 °C for short term (days to weeks) or -20 °C for long term (months to years)

Density: 1.72±0.10 g/cm3

Melting Point: 243-245 °C

Boiling Point: 523.9±60.0 °C at 760 mmHg

Flash Point: 270.7±32.9 °C

Shelf Life: 2 years

InChIKey: PPUDLEUZKVJXSZ-VPCXQMTMSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1(C(C(OC1N2C=CC(=NC2=O)N)CO)O)O

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1

Synonyms: 1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-4-aminopyrimidin-2(1H)-one; 2'-C-methyl-cytidine; valopicitabine; Cytidine, 2'-C-methyl-; (+)-2'-C-Methylcytidine; NM 107

Related CAS: 115494-60-5

2'-C-beta-Methylguanosine

Description: 2'-C-β-Methyl Guanosine is an anti-HCV agent. 2'-C-β-Methyl Guanosine is an intermediate in the synthesis of novel double prodrug INX-08189, a new clinical candidate for hepatitis C virus.

CAT: BRP-00060

CAS: 374750-30-8

Molecular Formula: C11H15N5O5

Molecular Weight: 297.27

Purity: ≥95%

Appearance: White to Beige Powder

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Storage: Store at -20°C

Density: 2.03 g/cm3

Boiling Point: 733.1±70.0°C (Predicted)

Application: A nucleoside derivative as antiviral, antitumor, and antidiabetic prodrug agents.

InChIKey: NVKAMPJSWMHVDK-GITKWUPZSA-N

Solubility: Soluble in Water

CanonicalSMILES: CC1(C(C(OC1N2C=NC3=C2N=C(NC3=O)N)CO)O)O

IUPAC Name: 2-amino-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1H-purin-6-one

InChI: InChI=1S/C11H15N5O5/c1-11(20)6(18)4(2-17)21-9(11)16-3-13-5-7(16)14-10(12)15-8(5)19/h3-4,6,9,17-18,20H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,9-,11-/m1/s1

Synonyms: 2'-C-Methylguanosine; 2'-C-β-Methyl Guanosine; 2-Amino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(2-C-methyl-beta-D-ribofuranosyl)-; INX 08032; INZ 08032

2'-C-Methyluridine

Description: 2'-C-Methyluridine is a 2'-C-Me branched C-nucleoside that shows HCV polymerase inhibitory activity.

CAT: BRP-00061

CAS: 31448-54-1

Molecular Formula: C10H14N2O6

Molecular Weight: 258.23

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

Density: 1.57 g/cm3

Melting Point: 110-112 °C

InChIKey: NBKORJKMMVZAOZ-VPCXQMTMSA-N

CanonicalSMILES: CC1(C(C(OC1N2C=CC(=O)NC2=O)CO)O)O

IUPAC Name: 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C10H14N2O6/c1-10(17)7(15)5(4-13)18-8(10)12-3-2-6(14)11-9(12)16/h2-3,5,7-8,13,15,17H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,10-/m1/s1

Synonyms: 2'-C-Methyl-1-β-D-ribofuranosyluracil; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-Methyl Uridine; 1,3-bis(N-cyclohexyl)guanidine; 1-(2-C-Methyl-β-D-ribofuranosyl)uracil; 2,4(1H,3H)-pyrimidinedione, 1-(2-C-methyl-β-D-ribofuranosyl)-

N6-Cyclopentyl-adenosine

Description: N6-Cyclopentyl-adenosine (CPA) - an adenosine analog and A1 adenosine receptor agonist - is pivotal in biomedicine as a research tool to inspect the part played by the adenosine receptor in distinct physiological processes. It also has potential therapeutic benefits that range from treating ischemia-reperfusion injuries to chronic pain.

CAT: BRP-00062

CAS: 41552-82-3

Molecular Formula: C15H21N5O4

Molecular Weight: 335.36

Purity: ≥95% by HPLC

Appearance: White to off-white solid

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Storage: Store at 2-8 °C

Density: 1.78±0.1 g/cm3 (Predicted)

Melting Point: 78.8 °C

Boiling Point: 673.4±65.0 °C at 760 mmHg

Application: Purinergic P1 Receptor Agonists

InChIKey: SQMWSBKSHWARHU-SDBHATRESA-N

Solubility: Soluble in Water

CanonicalSMILES: C1CCC(C1)NC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O

IUPAC Name: (2R,3R,4S,5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

InChI: InChI=1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1

Synonyms: N6-Cyclopentyladenosine; CPA; N-Cyclopentyladenosine; UK 80882; (2R,3R,4S,5R)-2-[6-(Cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

3'-O-Methyluridine

Description: 3'-O-Methyluridine is a potent compound, serving as a therapeutic intervention for research of diverse viral infections and autoimmune conditions. Through its exceptional anti-replication properties, this remarkable compound effectively hampers viral proliferation.

CAT: BRP-00064

CAS: 6038-59-1

Molecular Formula: C10H14N2O6

Molecular Weight: 258.23

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at -20°C

Density: 1.53±0.1 g/cm3

Melting Point: 142-145°C

InChIKey: YKNATSNMFLEFRB-ZOQUXTDFSA-N

CanonicalSMILES: COC1C(OC(C1O)N2C=CC(=O)NC2=O)CO

IUPAC Name: 1-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C10H14N2O6/c1-17-8-5(4-13)18-9(7(8)15)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1

Synonyms: 3'-O-Methyl-D-uridine; O3'-methyl-uridine; 1-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 3'-O-Me-Ur; 3'-O-methyl-uridine; 3'-(O-Methyl) Uridine

3'-O-Methyladenosine

Description: 3'-O-Methyladenosine, an indispensable biomolecule utilized in the realm of biomedical research, assumes a pivotal role in the meticulous exploration of RNA modifications. Ubiquitously present within a myriad of RNA molecules, this compound exerts profound influence on gene expression regulation, cellular signaling, and the genesis of diseases.

CAT: BRP-00065

CAS: 10300-22-8

Molecular Formula: C11H15N5O4

Molecular Weight: 281.27

Purity: ≥95%

Appearance: White Powder

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Storage: Store at -20°C

Density: 1.84±0.1 g/cm3(Predicted)

Melting Point: 177-178 °C

Boiling Point: 623.8±65.0 °C(Predicted)

InChIKey: RYAFZRROCNNRFK-IOSLPCCCSA-N

Solubility: Soluble in Methanol (10 mg/mL)

CanonicalSMILES: COC1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO

IUPAC Name: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-methoxyoxolan-3-ol

InChI: InChI=1S/C11H15N5O4/c1-19-8-5(2-17)20-11(7(8)18)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

Synonyms: 3'-O-Methyl-D-adenosine; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol; NSC 103062; 3'-O-Methyl Adenosine; 3'-(O-Methyl) Adenosine

N6-Benzoyl-2'-O-methyladenosine

Description: N6-Benzoyl-2'-O-methyladenosine is an indispensable compound in the realm of biomedical research assuming a paramount role in the exploration of RNA modifications and epigenetics.

CAT: BRP-00067

CAS: 85079-00-1

Molecular Formula: C18H19N5O5

Molecular Weight: 385.37

Purity: ≥95%

Appearance: Off-white to Pale Yellow Powder

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Storage: Store at RT

Density: 1.59±0.1 g/cm3 (Predicted)

InChIKey: PHFHSPQCDRKMQJ-XWXWGSFUSA-N

CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C18H19N5O5/c1-27-14-13(25)11(7-24)28-18(14)23-9-21-12-15(19-8-20-16(12)23)22-17(26)10-5-3-2-4-6-10/h2-6,8-9,11,13-14,18,24-25H,7H2,1H3,(H,19,20,22,26)/t11-,13-,14-,18-/m1/s1

Synonyms: N6-Benzoyl-2'-O-methyl-D-adenosine; Bz-2'-OMe-A; N-Benzoyl-2'-O-methyladenosine; N6-Benzoyl-2'-O-methyl-adenosine; 2'-O-methyl-N6-benzoyladenosine; N-(9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide; N6-Bz-2'-OMe-A; N6-Bz-2'-O-Me-Ar

N2-Isobutyryl-2'-O,4'-C-methyleneguanosine

Description: N2-Isobutyryl-2'-O,4'-C-methyleneguanosine is a potent antiviral compound used in the biomedical industry. It exhibits inhibitory activity against RNA viruses like Dengue and Zika viruses. This compound blocks viral replication by interfering with viral RNA synthesis. Its unique chemical structure makes it a valuable tool in antiviral drug discovery and development.

CAT: BRP-00069

CAS: 206055-68-7

Molecular Formula: C15H19N5O6

Molecular Weight: 365.34

Purity: ≥95%

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Density: 1.87±0.1 g/cm3

Melting Point: 196-199 °C

InChIKey: FUKSKECTPBMMEQ-BQOLRUCTSA-N

Solubility: Soluble in Water

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C4C(C(O3)(CO4)CO)O

IUPAC Name: N-[9-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C15H19N5O6/c1-6(2)11(23)18-14-17-10-7(12(24)19-14)16-5-20(10)13-8-9(22)15(3-21,26-13)4-25-8/h5-6,8-9,13,21-22H,3-4H2,1-2H3,(H2,17,18,19,23,24)/t8-,9+,13-,15+/m1/s1

Synonyms: guanosine, 2'-O,4'-C-methylene-N-(2-methyl-1-oxopropyl)-; (1S,3R,4R,7S)-7-Hydroxy-1-hydroxymethyl-3-(2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane; N-[6,9-Dihydro-6-oxo-9-[(1S,3R,4R,7S)-1-(hydroxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane-3-yl]-1H-purine-2-yl]isobutyramide

2'-O,4'-C-Methyleneuridine

Description: 2'-O,4'-C-Methyleneuridine, a biomedical compound, plays a pivotal role in the advancement of antiviral drugs and therapeutics. Its profound efficacy against a wide array of viral infections, namely hepatitis C virus (HCV) and respiratory syncytial virus (RSV), unveils its tremendous potential in combatting viral diseases.

CAT: BRP-00070

CAS: 200435-92-3

Molecular Formula: C10H12N2O6

Molecular Weight: 256.21

Purity: ≥95%

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Storage: Store at -20 °C

Density: 1.695 g/cm3

Melting Point: 239-243°C (methanol)

InChIKey: KNLNWXXWKDEEFW-JIOCBJNQSA-N

Solubility: Soluble in Methanol

CanonicalSMILES: C1C2(C(C(O1)C(O2)N3C=CC(=O)NC3=O)O)CO

IUPAC Name: 1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C10H12N2O6/c13-3-10-4-17-6(7(10)15)8(18-10)12-2-1-5(14)11-9(12)16/h1-2,6-8,13,15H,3-4H2,(H,11,14,16)/t6-,7+,8-,10+/m1/s1

Synonyms: 1-(2-O,4-C-Methylene-beta-D-ribofuranosyl)uracil; LNA-U; 1-[2,5-Anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-2,4(1H,3H)-pyrimidinedione; (1S,3R,4R,7S)-7-Hydroxy-1-hydroxymethyl-3-(uracil-1-yl)-2,5-dioxabicyclo-[2.2.1]heptane

5-Methyl-2'-O,4'-C-methyleneuridine

Description: 5-Methyl-2'-O,4'-C-methyleneuridine is a chemically modified nucleoside where a methylene bridge connects the 2'-oxygen and 4'-carbon of the ribose sugar, and the uridine base is methylated at the 5-position. This modification enhances the stability and binding affinity of RNA molecules, making it valuable in RNA research and therapeutic applications. It is often used to study RNA structure, function, and interactions, and in the development of novel RNA-based drugs.

CAT: BRP-00071

CAS: 206055-67-6

Molecular Formula: C11H14N2O6

Molecular Weight: 270.24

Purity: ≥95%

Appearance: White to light brown powder

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Storage: Store at 2-8 °C

Density: 1.598±0.1 g/cm³ (Predicted)

Melting Point: 196-198 °C

InChIKey: TYYUAZVXLRMUMN-SZVQBCOZSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C3C(C(O2)(CO3)CO)O

IUPAC Name: 1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C11H14N2O6/c1-5-2-13(10(17)12-8(5)16)9-6-7(15)11(3-14,19-9)4-18-6/h2,6-7,9,14-15H,3-4H2,1H3,(H,12,16,17)/t6-,7+,9-,11+/m1/s1

Synonyms: LNA-5MeU; 1-[(1S,3R,4R,7S)-7-Hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)thymine; 1-[2,5-Anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione