What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - RNA / BOC Sciences

N4-Benzoyl-2'-O-(2-methoxyethyl)cytidine

Description: N4-Benzoyl-2'-O-(2-methoxyethyl)cytidine, hailed as an efficacious and potent antiviral compound, is widely used for studying notorious Herpes Simplex Virus type 1 (HSV-1) and Hepatitis C Virus (HCV).

CAT: BRP-00357

CAS: 2305416-18-4

Molecular Formula: C19H23N3O7

Molecular Weight: 405.40

Purity: ≥95%

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Storage: Store at 2-8 °C

Density: 1.44±0.1 g/cm3 (Predicted)

InChIKey: VDTLYOJAWYZWEE-GFOCRRMGSA-N

CanonicalSMILES: COCCOC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)CO)O

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C19H23N3O7/c1-27-9-10-28-16-15(24)13(11-23)29-18(16)22-8-7-14(21-19(22)26)20-17(25)12-5-3-2-4-6-12/h2-8,13,15-16,18,23-24H,9-11H2,1H3,(H,20,21,25,26)/t13-,15-,16-,18-/m1/s1

Synonyms: 2'-O-MOE-rC(Bz); N-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

2'-O-Propargylcytidine

Description: 2'-O-Propargylcytidine, a compound of utmost importance in the biomedical sector, serves as an indispensable agent in combatting a myriad of afflictions. Garnering wide-ranging acclaim, it displays promising potential in thwarting the proliferation of menacing viruses like SARS-CoV and MERS-CoV. Furthermore, its notable efficacy in addressing diverse manifestations of neoplasms, notably pulmonary and mammary carcinoma, instills hope and marks it as a prime contender for the synthesis of revolutionary antiviral and anticarcinogenic therapeutics.

CAT: BRP-00358

CAS: 206552-85-4

Molecular Formula: C12H15N3O5

Molecular Weight: 281.26

Purity: ≥95% by HPLC

Appearance: White crystalline powder

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Storage: Store at 2-8 °C

Density: 1.51±0.1 g/cm3

Boiling Point: 544.7±60.0 °C at 760 mmHg

InChIKey: FJGRSBJPLPTKDE-QCNRFFRDSA-N

Solubility: Soluble in Methanol

CanonicalSMILES: C#CCOC1C(C(OC1N2C=CC(=NC2=O)N)CO)O

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C12H15N3O5/c1-2-5-19-10-9(17)7(6-16)20-11(10)15-4-3-8(13)14-12(15)18/h1,3-4,7,9-11,16-17H,5-6H2,(H2,13,14,18)/t7-,9-,10-,11-/m1/s1

Synonyms: 2'-O-propargyl-rC; 2'-O-Propargyl-D-cytidine; 4-amino-1-[(2-O-propargyl)-β-D-ribofuranosyl]-2H-pyrimidin-2-one; 2'-(O-Propargyl)-cytidine; 2'-O-2-Propyn-1-ylcytidine; Cytidine, 2'-O-2-propynyl-; 2'-(O-propargyl) Cytidine

2'-O-Propygylguanosine

Description: 2'-O-Propygylguanosine is a crucial compound extensively used in the biomedicine industry. This product acts as an antiviral agent, primarily targeting viral infections caused by RNA viruses. It demonstrates promising therapeutic potential in treating diseases like HIV, Ebola, and hepatitis C. Its unique structure and mechanism of action make it an invaluable tool in the fight against these life-threatening viral infections.

CAT: BRP-00360

CAS: 206552-86-5

Molecular Formula: C13H15N5O5

Molecular Weight: 321.29

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at 2-8 °C

Density: 1.8±0.1 g/cm3

Boiling Point: 737.5±70.0°C at 760 mmHg

InChIKey: VBIXIAQUDWOPDT-WOUKDFQISA-N

CanonicalSMILES: C#CCOC1C(C(OC1N2C=NC3=C2N=C(NC3=O)N)CO)O

IUPAC Name: 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]-1H-purin-6-one

InChI: InChI=1S/C13H15N5O5/c1-2-3-22-9-8(20)6(4-19)23-12(9)18-5-15-7-10(18)16-13(14)17-11(7)21/h1,5-6,8-9,12,19-20H,3-4H2,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s1

Synonyms: 2'-O-propargyl-rG; 2'-O-(2-Propyn-1-yl)guanosine; 2'-O-Propargyl-guanosine; 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 2'-O-2-Propyn-1-ylguanosine; 2'-O-propargyl-Gr; 2'-(O-Propargyl)-guanosine; 2'-(O-propargyl) Guanosine

N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine

Description: N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine is a remarkable biomedical compound possessing anti-inflammatory and anticancer properties.

CAT: BRP-00362

CAS: 127212-38-8

Molecular Formula: C39H37N5O7

Molecular Weight: 687.74

Purity: ≥95%

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Storage: Store at 2-8 °C

Density: 1.3±0.1 g/cm3

InChIKey: BXARQKKKQMVIEG-CJEGOSRCSA-N

CanonicalSMILES: COC1C(OC(C1O)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-hydroxy-4-methoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C39H37N5O7/c1-47-29-18-14-27(15-19-29)39(26-12-8-5-9-13-26,28-16-20-30(48-2)21-17-28)50-22-31-34(49-3)33(45)38(51-31)44-24-42-32-35(40-23-41-36(32)44)43-37(46)25-10-6-4-7-11-25/h4-21,23-24,31,33-34,38,45H,22H2,1-3H3,(H,40,41,43,46)/t31-,33-,34-,38-/m1/s1

Synonyms: 5'-O-DMTr-3'-O-Me-rA(Bz); N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-methyladenosine; N-(9-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-methyladenosine

2',3'-Di-O-methyladenosine

Description: 2',3'-Di-O-methyladenosine, a compound of utmost importance, finds extensive utility in the biomedical field owing to its immense potential for therapeutic purposes. In the realm of disease management, particularly in cancer, neurodegenerative disorders, and viral infections, this product assumes a pivotal role. Its remarkable chemical composition and distinct pharmacological characteristics render it an exceedingly propitious contender for targeted pharmaceutical administration and individualized medical interventions.

CAT: BRP-00363

CAS: 20649-46-1

Molecular Formula: C12H17N5O4

Molecular Weight: 295.29

Purity: ≥98% by HPLC

Appearance: White solid

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Storage: Store at 2-8 °C, under inert atmosphere

Density: 1.66±0.1 g/cm3

Melting Point: 167-172 °C

Boiling Point: 553.4±60.0 °C at 760 mmHg

InChIKey: YLTDWADIGWTCSP-WOUKDFQISA-N

Solubility: Soluble in DMSO (Slightly), Methanol (Slightly)

CanonicalSMILES: COC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)N)CO

IUPAC Name: [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dimethoxyoxolan-2-yl]methanol

InChI: InChI=1S/C12H17N5O4/c1-19-8-6(3-18)21-12(9(8)20-2)17-5-16-7-10(13)14-4-15-11(7)17/h4-6,8-9,12,18H,3H2,1-2H3,(H2,13,14,15)/t6-,8-,9-,12-/m1/s1

Synonyms: 2',3'-O-Me-rA; Adenosine, 2',3'-di-O-methyl-; ((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dimethoxytetrahydrofuran-2-yl)methanol; 2',3'-Dimethoxyadenosine

N6-Benzoyl-3'-O-methyladenosine

Description: N6-Benzoyl-3'-O-methyladenosine, a modified nucleoside, plays a vital role in biomedicine research by uncovering the intricate pathways of RNA modification and its impact on the onset of disease. It has sparked significant interest due to its potential application as a therapeutic tool in cancer and other diseases by regulating gene expression. The interaction of this compound with specific enzymes involved in RNA processing and modification elucidates the complexity of these biological processes, making it a precious commodity in the research field.

CAT: BRP-00364

CAS: 85090-30-8

Molecular Formula: C18H19N5O5

Molecular Weight: 385.37

Purity: 96%

Appearance: White to Off-white Powder to Crystalline Powder

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Storage: Store at 2-8°C

Density: 1.59±0.1 g/cm3 (Predicted)

InChIKey: MCFYIRSCNBGQBD-XWXWGSFUSA-N

CanonicalSMILES: COC1C(OC(C1O)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO

IUPAC Name: N-[9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C18H19N5O5/c1-27-14-11(7-24)28-18(13(14)25)23-9-21-12-15(19-8-20-16(12)23)22-17(26)10-5-3-2-4-6-10/h2-6,8-9,11,13-14,18,24-25H,7H2,1H3,(H,19,20,22,26)/t11-,13-,14-,18-/m1/s1

Synonyms: N6-Benzoyl-3'-O-methyl-D-adenosine; N-Benzoyl-3'-O-methyladenosine; N-(9-((2R,3R,4S,5R)-3-Hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide; 3'-O-Me-rA(Bz)

3'-O-TBDMS-2'-O-Me-rG(iBu)

Description: Guanosine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl) - the nucleoside analog believed to hold great potential in the fight against a wide range of viral infections and certain cancers. Extensively researched for its ability to disrupt viral or cancerous DNA replication, Guanosine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl) has been shown to be effective against HCV, HIV, herpes simplex virus, leukemia and lung cancer - making it a powerful tool in the battle against these debilitating diseases.

CAT: BRP-00365

CAS: 863097-97-6

Molecular Formula: C21H35N5O6Si

Molecular Weight: 481.62

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.32±0.1 g/cm3

InChIKey: CEEYEENCDIBWAI-QEPJRFBGSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O[Si](C)(C)C(C)(C)C)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C21H35N5O6Si/c1-11(2)17(28)24-20-23-16-13(18(29)25-20)22-10-26(16)19-15(30-6)14(12(9-27)31-19)32-33(7,8)21(3,4)5/h10-12,14-15,19,27H,9H2,1-8H3,(H2,23,24,25,28,29)/t12-,14-,15-,19-/m1/s1

Synonyms: 3'-O-[(1,1-Dimethylethyl)dimethylsilyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)guanosine; Guanosine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-; N-(9-((2R,3R,4R,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-3H-purin-2-yl)isobutyramide

Related CAS: 1345716-51-9 (Deleted CAS) ; 2919005-85-7 (Deleted CAS)

N-Butyl Molnupiravir

Description: An impurity of Molnupiravir which is an antiviral drug with promising activity against the SARS-CoV-2 virus.

CAT: BRP-00367

CAS: 2770244-32-9

Molecular Formula: C13H19N3O7

Molecular Weight: 329.31

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.61±0.1 g/cm3

InChIKey: UFRPBGZCTRKUTJ-FAQVLOEFSA-N

CanonicalSMILES: CCCC(=O)OCC1C(C(C(O1)N2C=CC(=NC2=O)NO)O)O

IUPAC Name: [(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl butanoate

InChI: InChI=1S/C13H19N3O7/c1-2-3-9(17)22-6-7-10(18)11(19)12(23-7)16-5-4-8(15-21)14-13(16)20/h4-5,7,10-12,18-19,21H,2-3,6H2,1H3,(H,14,15,20)/t7-,10-,11-,12-/m1/s1

Synonyms: N4-OH-5'-O-Butyryl-rC; ((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl butyrate

Tetrahydrouridine

Description: Tetrahydrouridine, a derivative of Uridine, is a potent and reversible competitive inhibitor of cytidine deaminase (CDD) (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively). Tetrahydrouridine has the potential to treat tumors with highly expressed CDA as it inhibits cell proliferation through cell cycle regulation despite of cytidine deaminase expression levels deaminase (CDA). Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies.

CAT: BRP-00368

CAS: 18771-50-1

Molecular Formula: C9H16N2O6

Molecular Weight: 248.23

Purity: 95%

Appearance: Solid powder

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Storage: Store at 2-8 °C

Density: 1.622±0.06 g/cm3

Boiling Point: 668.6±55.0 °C at 760 mmHg

Application: Antimetabolites

InChIKey: UCKYOOZPSJFJIZ-XVKVHKPRSA-N

CanonicalSMILES: C1CN(C(=O)NC1O)C2C(C(C(O2)CO)O)O

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one

InChI: 1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1

Synonyms: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one; NSC 112907; NSC-112907; NSC112907; 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-β-D-ribofuranosyl-; 3,4,5,6-Tetrahydrouridine; 1-(β-D-Ribofuranosyl)-4-hydroxytetrahydro-1(1H)-pyrimidinone

N4-Acetyl-5'-O-(dimethoxytrityl)-5-methyl-2'-O-methylcytidine

Description: N4-Acetyl-5'-O-(dimethoxytrityl)-5-methyl-2'-O-methylcytidine, a modified cytidine, has become an integral component of nucleoside analogues in the biomedical industry. This versatile molecule serves as a unit in the development of antiviral drugs designed to impact viral RNA polymerase and reverse transcriptase while also being investigated for its potential as an anticancer agent. Its utility and importance continue to make it a crucial element in modern biology and medicine.

CAT: BRP-00378

CAS: 869355-20-4

Molecular Formula: C34H37N3O8

Molecular Weight: 615.68

Purity: ≥95%

Appearance: White to light yellow powder

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Density: 1.27±0.1 g/cm3

InChIKey: AICFKYRNVVDUMK-PBAMLIMUSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C34H37N3O8/c1-21-19-37(33(40)36-31(21)35-22(2)38)32-30(43-5)29(39)28(45-32)20-44-34(23-9-7-6-8-10-23,24-11-15-26(41-3)16-12-24)25-13-17-27(42-4)18-14-25/h6-19,28-30,32,39H,20H2,1-5H3,(H,35,36,38,40)/t28-,29-,30-,32-/m1/s1

Synonyms: 5'-O-DMT-N4-Ac-2'-O-Methy-5-Methycytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-methylcytidine; N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)guanosine, 2',3'-diacetate

Description: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)guanosine, 2',3'-diacetate is a chemically modified guanosine nucleoside. This compound features a 5'-O protection with a bis(4-methoxyphenyl)phenylmethyl (also known as DMT) group, an N-(2-methyl-1-oxopropyl) group at the guanine base, and acetyl groups protecting both the 2' and 3' hydroxyl positions of the ribose sugar. These modifications enhance stability and facilitate selective reactions during oligonucleotide synthesis. This compound is particularly useful in the preparation of modified nucleic acids for research in molecular biology, providing increased control over the synthesis and modification of RNA and DNA molecules.

CAT: BRP-00380

CAS: 210362-16-6

Molecular Formula: C39H41N5O10

Molecular Weight: 739.77

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Density: 1.35±0.1 g/cm3

InChIKey: BSJXJCSWIJAQGJ-GONXPTGJSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-4-acetyloxy-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] acetate

InChI: InChI=1S/C39H41N5O10/c1-22(2)35(47)42-38-41-34-31(36(48)43-38)40-21-44(34)37-33(53-24(4)46)32(52-23(3)45)30(54-37)20-51-39(25-10-8-7-9-11-25,26-12-16-28(49-5)17-13-26)27-14-18-29(50-6)19-15-27/h7-19,21-22,30,32-33,37H,20H2,1-6H3,(H2,41,42,43,47,48)/t30-,32-,33-,37-/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-, 2',3'-diacetate; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate; 2',3'-di-Ac-5'-DMT-G(iBu)

Uridine 5-α-hydroxyacetamide

Description: Uridine 5-α-hydroxyacetamide is a modified nucleoside derived from uridine, where the 5-position of the uracil base is functionalized with an α-hydroxyacetamide group (-CH(OH)CONH2). This modification introduces both a hydroxyl group and an amide functionality, increasing its potential for hydrogen bonding and reactivity. Such structural changes can significantly influence the molecule's biochemical interactions, making it useful in studying nucleotide analogs, enzyme-substrate specificity, or as a precursor in the synthesis of therapeutic nucleotides. Its unique functional groups also allow for further chemical derivatization or conjugation in research and drug development applications.

CAT: BRP-00386

CAS: 2450329-74-3

Molecular Formula: C11H15N3O8

Molecular Weight: 317.25

Purity: ≥97%

Appearance: White or off-white solid

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Storage: Store at RT

Density: 1.785±0.06 g/cm3

InChIKey: CMLZLJSTEBFOFC-XXWJQXOGSA-N

CanonicalSMILES: C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(C(=O)N)O

IUPAC Name: 2-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-2-hydroxyacetamide

InChI: InChI=1S/C11H15N3O8/c12-8(19)5(16)3-1-14(11(21)13-9(3)20)10-7(18)6(17)4(2-15)22-10/h1,4-7,10,15-18H,2H2,(H2,12,19)(H,13,20,21)/t4-,5?,6-,7-,10-/m1/s1

Synonyms: Uridine 5-α-hydroxy acetamide; 5-Carbamoylhydroxy methyluridine; (R/S)-5-Carbamoylhydroxy methyluridine; racemic, RNA nucleoside nchm5U; 5-Carbamoylhydroxymethyluridine; 2-(1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-hydroxyacetamide; Uridine 5-alpha-hydroxy acetamide

4′-C-Fluoro-2′-C-methyluridine

Description: 4'-C-Fluoro-2'-C-methyluridine is a modified form of uridine where the oxygen at the 2' position of the ribose sugar is replaced by a methyl group, and a fluorine atom is attached to the carbon at the 4' position of the ribose sugar. This modification enhances the stability and binding affinity of the nucleotide, making it useful in various molecular biology applications, including RNA structure studies, antisense oligonucleotide design, and as a substrate for enzymatic reactions in RNA biochemistry research.

CAT: BRP-00392

CAS: 1613589-04-0

Molecular Formula: C10H13FN2O6

Molecular Weight: 276.22

Purity: ≥95%

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Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Density: 1.68±0.1 g/cm3

InChIKey: NVGHRKFZVNJJFZ-MVHNUAHISA-N

CanonicalSMILES: O[C@]1(C)[C@H](O)[C@](CO)(F)O[C@H]1N2C(NC(C=C2)=O)=O

IUPAC Name: 1-[(2R,3R,4S,5S)-5-fluoro-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C10H13FN2O6/c1-9(18)6(16)10(11,4-14)19-7(9)13-3-2-5(15)12-8(13)17/h2-3,6-7,14,16,18H,4H2,1H3,(H,12,15,17)/t6-,7+,9+,10+/m0/s1

Synonyms: 1613589-04-0;1-[(2R,3R,4S,5S)-5-fluoro-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione;Adafosbuvir PM;SCHEMBL15817679;Uridine, 4'-C-fluoro-2'-C-methyl-;TS-09379;1-((2R,3R,4S,5S)-5-Fluoro-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;

N-Acetyl-2',3'-Acetyl-Guanosine

Description: N-Acetyl-2',3'-O-acetylguanosine is a modified nucleoside derived from guanosine, a component of RNA. In this modified form, an acetyl group is attached to the 2' and 3' positions of the ribose sugar of guanosine, and an additional acetyl group is attached to the N6 position of the guanine base. This modification alters the chemical properties of guanosine, potentially affecting its interactions with other molecules, its stability, or its role in biological processes. N-Acetyl-2',3'-O-acetylguanosine is often used in biochemical and molecular biology research as a tool to study RNA structure, function, and metabolism. It may also have potential applications in RNA-based therapeutics or diagnostics.

CAT: BRP-00425

CAS: 65360-02-3

Molecular Formula: C16H19N5O8

Molecular Weight: 409.35

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Density: 1.72±0.1 g/cm3

InChIKey: KYQBEZWLVKJJHO-SDBHATRESA-N

CanonicalSMILES: CC(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1H-purin-9-yl)-4-acetyloxy-2-(hydroxymethyl)oxolan-3-yl] acetate

InChI: InChI=1S/C16H19N5O8/c1-6(23)18-16-19-13-10(14(26)20-16)17-5-21(13)15-12(28-8(3)25)11(27-7(2)24)9(4-22)29-15/h5,9,11-12,15,22H,4H2,1-3H3,(H2,18,19,20,23,26)/t9-,11-,12-,15-/m1/s1

Synonyms: Guanosine, N-acetyl-, 2',3'-diacetate; (2R,3R,4R,5R)-2-(2-Acetamido-6-oxo-3,6-dihydro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diyl diacetate

5'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine

Description: 5'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine is a chemically modified ribonucleoside used in oligonucleotide synthesis. This compound features a 5'-O-tert-butyldimethylsilyl (TBDMS) protecting group on the ribose sugar, providing stability during chemical synthesis, and an N2-isobutyryl (ibu) protecting group on the guanine base. These modifications facilitate the incorporation of guanosine into RNA sequences while protecting reactive groups, ensuring precise and efficient synthesis of RNA oligonucleotides for various applications in molecular biology and biochemistry.

CAT: BRP-00462

CAS: 89494-39-3

Molecular Formula: C20H33N5O6Si

Molecular Weight: 467.59

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

Density: 1.37±0.1 g/cm3

InChIKey: RUKACXRBRJHKDV-XWXWGSFUSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO[Si](C)(C)C(C)(C)C)O)O

IUPAC Name: N-[9-[(2R,3R,4S,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C20H33N5O6Si/c1-10(2)16(28)23-19-22-15-12(17(29)24-19)21-9-25(15)18-14(27)13(26)11(31-18)8-30-32(6,7)20(3,4)5/h9-11,13-14,18,26-27H,8H2,1-7H3,(H2,22,23,24,28,29)/t11-,13-,14-,18-/m1/s1

Synonyms: 5'-O-[(1,1-Dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)guanosine; N-(9-((2R,3R,4S,5R)-5-((tert-butyldimethylsilyloxy)methyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; 5'-TBDMS-ibu-rG

3',5'-TIPS-N-AC-Guanosine

Description: 3',5'-TIPS-N-AC-Guanosine is a chemically modified nucleoside used in nucleic acid synthesis. It contains 3',5'-TIPS protecting groups on the ribose sugar and an N-AC modification on the guanine base. These modifications enable precise control over nucleotide incorporation while protecting reactive sites, facilitating efficient synthesis of modified nucleic acids for applications in molecular biology and biochemistry.

CAT: BRP-00463

CAS: 847979-69-5

Molecular Formula: C24H41N5O7Si2

Molecular Weight: 567.78

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

Density: 1.34±0.1 g/cm3

InChIKey: MURIXOGCFLEACT-ZDXOVATRSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C)NC2=C1N=CN2C3OC4CO[Si](O[Si](OC4C3O)(C(C)C)C(C)C)(C(C)C)C(C)C

IUPAC Name: N-(9-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

InChI: InChI=1S/C24H41N5O7Si2/c1-12(2)37(13(3)4)33-10-17-20(35-38(36-37,14(5)6)15(7)8)19(31)23(34-17)29-11-25-18-21(29)27-24(26-16(9)30)28-22(18)32/h11-15,17,19-20,23,31H,10H2,1-9H3,(H2,26,27,28,30,32)/t17-,19-,20-,23-/m1/s1

Synonyms: N-Acetyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]guanosine

5'-DMTr-2'-O-MOE-rG(iBu)-3'-succinate TEA salt

Description: 5'-DMTr-2'-O-MOE-rG(iBu)-3'-succinate TEA salt, utilized in oligonucleotide synthesis, features a 5'-DMTr protecting group and a 3'-succinate group. The nucleoside unit is guanosine (rG), modified with a 2'-O-methoxyethyl (MOE) group and isobutyryl (iBu) protection on the guanine amino group. The TEA salt formulation improves solubility. It is employed in the synthesis of modified RNA sequences with improved stability and target specificity, suitable for applications such as RNA interference (RNAi) and RNA-based therapeutics.

CAT: BRP-00602

CAS: 2622236-65-9

Molecular Formula: C42H47N5O12.C6H15N

Molecular Weight: 915.05

Purity: ≥98%

Appearance: White to yellow powder

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Storage: Store at -20 °C

InChIKey: IWABYMODQWLWLW-OYXYNOIHSA-N

CanonicalSMILES: CCN(CC)CC.CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OC(=O)CCC(=O)O)OCCOC

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C42H47N5O12.C6H15N/c1-25(2)38(51)45-41-44-37-34(39(52)46-41)43-24-47(37)40-36(56-22-21-53-3)35(59-33(50)20-19-32(48)49)31(58-40)23-57-42(26-9-7-6-8-10-26,27-11-15-29(54-4)16-12-27)28-13-17-30(55-5)18-14-28;1-4-7(5-2)6-3/h6-18,24-25,31,35-36,40H,19-23H2,1-5H3,(H,48,49)(H2,44,45,46,51,52);4-6H2,1-3H3/t31-,35-,36-,40-;/m1./s1

Synonyms: Triethylamine 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoate; 5'-DMT-2'-O-MOE-G(iBu)-3'-succinate, TEA salt; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine-3'-O-succinate, triethylamine salt

Related CAS: 2622236-64-8 (free base)

5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU is a modified nucleoside where a POM-(E)-vinyl phosphonate group is attached to the 5'-position and a 2'-O-methyl group is attached to the ribose of uridine (rU). This modification can alter the nucleotide's stability and interactions with enzymes involved in nucleic acid synthesis and modification. It is used in biochemical research to study RNA synthesis, RNA-protein interactions, and the development of nucleotide analogs for therapeutic applications.

CAT: BRP-00705

CAS: 2172373-51-0

Molecular Formula: C23H35N2O12P

Molecular Weight: 562.51

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.34±0.1 g/cm3

InChIKey: IQVFHCHMSAXIBF-QSEATPFUSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C(O)C2OC

IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C23H35N2O12P/c1-22(2,3)19(28)33-12-35-38(31,36-13-34-20(29)23(4,5)6)11-9-14-16(27)17(32-7)18(37-14)25-10-8-15(26)24-21(25)30/h8-11,14,16-18,27H,12-13H2,1-7H3,(H,24,26,30)/b11-9+/t14-,16-,17-,18-/m1/s1

Synonyms: 1-[(5E)-6-[Bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]-5,6-dideoxy-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-2,4(1H,3H)-pyrimidinedione; POM-(E)-vinyl phosphonate-2'-O-Me-rU; 5'-POM-vinyl phosphonate, 2'-OMe-U; 5'-VP-2'-OME-U; 5'-(E)-VP-2'-OMe-U

3'-O-DMTr-2'-O-Me-rG(iBu)

Description: 3'-O-DMTr-2'-O-Me-rG(iBu) is a modified ribonucleoside where a dimethoxytrityl (DMTr) group is attached to the 3'-hydroxyl, a methyl group is attached to the 2'-hydroxyl of the ribose, and an isobutyryl (iBu) group protects the exocyclic amine of guanine (rG). This compound is utilized in the synthesis of oligonucleotides, offering enhanced stability and selective reactivity in solid-phase synthesis for RNA research and therapeutic applications.

CAT: BRP-00706

Molecular Formula: C36H39N5O8

Molecular Weight: 669.74

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

InChIKey: VNMWCNBFDWYPHY-WIFIACMTSA-N

IUPAC Name: N-(9-((2R,3R,4R,5R)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C36H39N5O8/c1-21(2)32(43)39-35-38-31-28(33(44)40-35)37-20-41(31)34-30(47-5)29(27(19-42)48-34)49-36(22-9-7-6-8-10-22,23-11-15-25(45-3)16-12-23)24-13-17-26(46-4)18-14-24/h6-18,20-21,27,29-30,34,42H,19H2,1-5H3,(H2,38,39,40,43,44)/t27-,29-,30-,34-/m1/s1

3'-O-DMTr-2'-O-Me-rU

Description: 3'-O-DMTr-2'-O-Me-rU is a modified ribonucleoside with a dimethoxytrityl (DMTr) group at the 3'-hydroxyl and a methyl group at the 2'-hydroxyl of the ribose moiety, based on uridine (rU). It is used in the chemical synthesis of RNA oligonucleotides, providing increased stability and protecting groups that facilitate efficient coupling reactions during oligonucleotide assembly, particularly in research and therapeutic RNA applications.

CAT: BRP-00707

CAS: 801295-70-5

Molecular Formula: C31H32N2O8

Molecular Weight: 560.60

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.35±0.1 g/cm3

InChIKey: GAGVWDWBNQZNFA-YXINZVNLSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(CO)C(OC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C2OC

IUPAC Name: 1-((2R,3R,4R,5R)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

InChI: InChI=1S/C31H32N2O8/c1-37-23-13-9-21(10-14-23)31(20-7-5-4-6-8-20,22-11-15-24(38-2)16-12-22)41-27-25(19-34)40-29(28(27)39-3)33-18-17-26(35)32-30(33)36/h4-18,25,27-29,34H,19H2,1-3H3,(H,32,35,36)/t25-,27-,28-,29-/m1/s1

Synonyms: Uridine, 3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-