What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - RNA / BOC Sciences

2'-O-(2-Fluoroethyl)-5-methyluridine

Description: 2'-O-(2-Fluoroethyl)-5-methyluridine is a modified nucleoside used in oligonucleotide synthesis. It is a nucleoside where a 2-fluoroethyl group is attached to the 2' position of ribose and a methyl group (Me) is attached to the 5th position of uracil. This modified nucleoside is employed in oligonucleotide synthesis to introduce specific structural features or properties into the oligonucleotide sequence, which can affect RNA structure, stability, or interactions with other molecules.

CAT: BRP-01023

CAS: 860640-48-8

Molecular Formula: C12H17FN2O6

Molecular Weight: 304.27

Purity: ≥98% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.47±0.1 g/cm3

InChIKey: GLPXIFDTRGSUFI-TURQNECASA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)OCCF

IUPAC Name: 1-[(2R,3R,4R,5R)-3-(2-fluoroethoxy)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C12H17FN2O6/c1-6-4-15(12(19)14-10(6)18)11-9(20-3-2-13)8(17)7(5-16)21-11/h4,7-9,11,16-17H,2-3,5H2,1H3,(H,14,18,19)/t7-,8-,9-,11-/m1/s1

Synonyms: 5-methyl-2'-O-(2-fluoroethyl)-uridine; 5-Me-2'-O-(2-fluoroethyl)-Ur; 1-((2R,3R,4R,5R)-3-(2-fluoroethoxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

5-Aminoallyl uridine

Description: 5-Aminoallyl uridine is a modified nucleoside used in oligonucleotide synthesis. It is a nucleoside where an aminoallyl group is attached to the 5th position of uridine. This modification is commonly employed in oligonucleotide synthesis for various applications such as labeling, conjugation, or attachment of fluorophores, biotin, or other molecules for downstream applications like microarray analysis, RNA labeling, or affinity purification.

CAT: BRP-01024

CAS: 97695-16-4

Molecular Formula: C12H17N3O6

Molecular Weight: 299.28

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Density: 1.632±0.06 g/cm3

InChIKey: FERHGDYGOMEXLT-TURQNECASA-N

CanonicalSMILES: C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)O)C=CCN

IUPAC Name: 5-(3-aminoprop-1-enyl)-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C12H17N3O6/c13-3-1-2-6-4-15(12(20)14-10(6)19)11-9(18)8(17)7(5-16)21-11/h1-2,4,7-9,11,16-18H,3,5,13H2,(H,14,19,20)/t7-,8-,9-,11-/m1/s1

Synonyms: 5-amineallyl-uridine; 5-(3-Amino-1-propen-1-yl)-Uridine; 5-amineallyl-Ur; 5-(3-Amino-1-propen-1-yl)uridine; Uridine, 5-(3-amino-1-propenyl)-; 5-(3-aminoallyl)uridine

2',3',5'-O-TBDMS-A(Bz)

Description: 2',3',5'-O-TBDMS-A(Bz) consists of an adenosine (A) nucleotide modified with a highly protected 2',3',5'-tri-tert-butyldimethylsilyl (TBDMS) group at the ribose, along with a benzoyl (Bz) group attached. This structure is employed in oligonucleotide synthesis to introduce adenosine residues with robust protection, ensuring stability and compatibility throughout synthesis and subsequent reactions.

CAT: BRP-01197

CAS: 86529-09-1

Molecular Formula: C35H59N5O5Si3

Molecular Weight: 714.14

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C

Density: 1.09±0.1 g/cm3

InChIKey: WPSOJPUXGQJMCS-CRDHKZEPSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[9-[(2R,3R,4R,5R)-3,4-bis[[tert-butyl(dimethyl)silyl]oxy]-5-[[tert-butyl(dimethyl)silyl]oxymethyl]oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C35H59N5O5Si3/c1-33(2,3)46(10,11)42-21-25-27(44-47(12,13)34(4,5)6)28(45-48(14,15)35(7,8)9)32(43-25)40-23-38-26-29(36-22-37-30(26)40)39-31(41)24-19-17-16-18-20-24/h16-20,22-23,25,27-28,32H,21H2,1-15H3,(H,36,37,39,41)/t25-,27-,28-,32-/m1/s1

Synonyms: N6-benzoyl-2',3',5'-tri-O-(tert-Butyldimethylsilyl)-A(Bz); N-Benzoyl-2',3',5'-tris-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine

3',5'-TIPDS-2'-OMe-2,6-diamino-purine-ribose

Description: 3',5'-TIPDS-2'-OMe-2,6-diamino-purine-ribose involves a ribose sugar modified with 3',5'-di-tert-isopropylsilyl (TIPDS) groups and a 2'-O-methyl group, linked to a 2,6-diamino-purine base. This compound is utilized in oligonucleotide synthesis for specific modifications at the ribose and nucleobase levels, enhancing stability and functionality in various biochemical and therapeutic applications.

CAT: BRP-01198

CAS: 128219-75-0

Molecular Formula: C23H42N6O5Si2

Molecular Weight: 538.80

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Density: 1.31±0.1 g/cm3

Boiling Point: 615.7±65.0 °C at 760 mmHg

InChIKey: MMHILCBTBJRYCQ-WGQQHEPDSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)N3C=NC4=C(N=C(N=C43)N)N)OC)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: 9-[(6aR,8R,9R,9aR)-9-methoxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]purine-2,6-diamine

InChI: InChI=1S/C23H42N6O5Si2/c1-12(2)35(13(3)4)31-10-16-18(33-36(34-35,14(5)6)15(7)8)19(30-9)22(32-16)29-11-26-17-20(24)27-23(25)28-21(17)29/h11-16,18-19,22H,10H2,1-9H3,(H4,24,25,27,28)/t16-,18-,19-,22-/m1/s1

Synonyms: 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-2,6-diamino-purine-ribose; Adenosine, 2-amino-2'-O-methyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-; 9-((6aR,8R,9R,9aR)-2,2,4,4-tetraisopropyl-9-methoxytetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purine-2,6-diamine

3',5'-TIPDS-pU

Description: 3',5'-TIPDS-pU features a ribose sugar protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups, linked to a pseudouridine (pU) nucleoside. This structure is used in oligonucleotide synthesis to introduce pseudouridine modifications, which can influence RNA structure, function, and stability in biological systems.

CAT: BRP-01199

CAS: 80545-49-9

Molecular Formula: C21H38N2O7Si2

Molecular Weight: 486.71

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Density: 1.16±0.1 g/cm3

InChIKey: UDNONSPJEFNIKP-YDZRNGNQSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)C3=CNC(=O)NC3=O)O)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: 5-[(6aR,8S,9S,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-1H-pyrimidine-2,4-dione

InChI: InChI=1S/C21H38N2O7Si2/c1-11(2)31(12(3)4)27-10-16-19(29-32(30-31,13(5)6)14(7)8)17(24)18(28-16)15-9-22-21(26)23-20(15)25/h9,11-14,16-19,24H,10H2,1-8H3,(H2,22,23,25,26)/t16-,17+,18+,19-/m1/s1

Synonyms: 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-pseudouridine; 5-((6aR,8S,9S,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione; 5-[3,5-O-[1,1,3,3-Tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione

N2-Bz-3',5'-TIPDS-iso-Cr

Description: N2-Bz-3',5'-TIPDS-iso-Cr is a modified cytidine nucleotide where the nitrogen at position 2 (N2) of the cytosine base is protected with a benzoyl (Bz) group. The ribose sugar at positions 3' and 5' is protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups. This modification enhances the stability and specificity of the nucleotide during oligonucleotide synthesis, crucial for applications in nucleic acid research and biotechnology.

CAT: BRP-01200

CAS: 2940876-61-7

Molecular Formula: C28H43N3O7Si2

Molecular Weight: 589.83

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Density: 1.23±0.1 g/cm3

InChIKey: XMTLUQOKYPYIFK-LYPBTDJXSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)N(C=C1)C3OC4CO[Si](O[Si](OC4C3O)(C(C)C)C(C)C)(C(C)C)C(C)C

IUPAC Name: N-(1-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-4-oxo-1,4-dihydropyrimidin-2-yl)benzamide

InChI: InChI=1S/C28H43N3O7Si2/c1-17(2)39(18(3)4)35-16-22-25(37-40(38-39,19(5)6)20(7)8)24(33)27(36-22)31-15-14-23(32)29-28(31)30-26(34)21-12-10-9-11-13-21/h9-15,17-20,22,24-25,27,33H,16H2,1-8H3,(H,29,30,32,34)/t22-,24-,25-,27-/m1/s1

Synonyms: N2-benzoyl-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-iso-cytidine

N6-iBu-3',5'-TIPDS-Ar

Description: N6-iBu-3',5'-TIPDS-Ar features an adenosine nucleotide where the nitrogen at position 6 (N6) of the adenine base is protected with an isobutyryl (iBu) group. Similarly, the ribose sugar at positions 3' and 5' is protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups. This modification is used in oligonucleotide synthesis to introduce modified adenosine residues, ensuring stability and enhancing functionality in nucleic acid applications.

CAT: BRP-01201

CAS: 163774-15-0

Molecular Formula: C26H45N5O6Si2

Molecular Weight: 579.84

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Density: 1.27±0.1 g/cm3

InChIKey: ZYESLHXCOCSGRD-RKCWLVDCSA-N

CanonicalSMILES: CC(C)C(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)CO[Si](O[Si](O4)(C(C)C)C(C)C)(C(C)C)C(C)C)O

IUPAC Name: N-[9-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]purin-6-yl]-2-methylpropanamide

InChI: InChI=1S/C26H45N5O6Si2/c1-14(2)25(33)30-23-20-24(28-12-27-23)31(13-29-20)26-21(32)22-19(35-26)11-34-38(15(3)4,16(5)6)37-39(36-22,17(7)8)18(9)10/h12-19,21-22,26,32H,11H2,1-10H3,(H,27,28,30,33)/t19-,21-,22-,26-/m1/s1

Synonyms: N6-isobutyryl-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-adenosine; N-(9-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)isobutyramide; N-(2-Methyl-1-oxopropyl)-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine

N2-dmf-3',5'-TIPDS-Gr

Description: N2-dmf-3',5'-TIPDS-Gr comprises a guanosine nucleotide where the nitrogen at position 2 (N2) of the guanine base is protected with a dimethylformamide (dmf) group. The ribose sugar at positions 3' and 5' is protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups. This modification is applied in oligonucleotide synthesis to incorporate modified guanosine residues, ensuring stability and compatibility in various nucleic acid studies.

CAT: BRP-01202

CAS: 120853-22-7

Molecular Formula: C25H44N6O6Si2

Molecular Weight: 580.83

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Density: 1.28±0.1 g/cm3

InChIKey: SQVNAKSYJCMYQC-UMCMBGNQSA-N

CanonicalSMILES: O=C1N=C(N=CN(C)C)NC2=C1N=CN2C3OC4CO[Si](O[Si](OC4C3O)(C(C)C)C(C)C)(C(C)C)C(C)C

IUPAC Name: N'-(9-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

InChI: InChI=1S/C25H44N6O6Si2/c1-14(2)38(15(3)4)34-11-18-21(36-39(37-38,16(5)6)17(7)8)20(32)24(35-18)31-13-26-19-22(31)28-25(29-23(19)33)27-12-30(9)10/h12-18,20-21,24,32H,11H2,1-10H3,(H,28,29,33)/t18-,20-,21-,24-/m1/s1

Synonyms: N2-dimethylformamidine-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-guanosine; N-[(Dimethylamino)methylene]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]guanosine

N4-Bz-3',5'-TIPDS-5-Me-Cr

Description: N4-Bz-3',5'-TIPDS-5-Me-Cr is a modified cytidine nucleotide where the nitrogen at position 4 (N4) of the cytosine base is protected with a benzoyl (Bz) group. Similar to the other compounds, the ribose sugar at positions 3' and 5' is protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups. This modification is utilized in oligonucleotide synthesis to introduce modified cytidine residues, enhancing stability and specificity for applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01203

CAS: 2940859-44-7

Molecular Formula: C29H45N3O7Si2

Molecular Weight: 603.85

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Density: 1.22±0.1 g/cm3

InChIKey: NSDMZZWBUMTBDG-PAHOUZJPSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)C(=CN1C3OC4CO[Si](O[Si](OC4C3O)(C(C)C)C(C)C)(C(C)C)C(C)C)C

IUPAC Name: N-(1-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C29H45N3O7Si2/c1-17(2)40(18(3)4)36-16-23-25(38-41(39-40,19(5)6)20(7)8)24(33)28(37-23)32-15-21(9)26(31-29(32)35)30-27(34)22-13-11-10-12-14-22/h10-15,17-20,23-25,28,33H,16H2,1-9H3,(H,30,31,34,35)/t23-,24-,25-,28-/m1/s1

Synonyms: N4-benzoyl-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-5-methyl-cytidine

5'-O-DMT-2'-O-TBDMS-N6-Acetyl-Adenosine

Description: 5'-O-DMT-2'-O-TBDMS-N6-Acetyl-Adenosine is a modified nucleoside where adenosine is altered with an acetyl group attached to the N6 position. It features protective groups (DMT and TBDMS) on the 5'- and 2'- hydroxyl groups respectively, which enhance stability and solubility in biochemical assays. This modification is useful in RNA synthesis and modification studies, allowing researchers to investigate how specific chemical alterations affect nucleic acid function and interactions with proteins.

CAT: BRP-01221

CAS: 1115247-32-9

Molecular Formula: C39H47N5O7Si

Molecular Weight: 725.92

Purity: ≥97% by HPLC

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Density: 1.23±0.1 g/cm3

InChIKey: VDNBCIWKZZGQST-SPBWOXKUSA-N

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(O)C3O[Si](C)(C)C(C)(C)C)C

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)acetamide

InChI: InChI=1S/C39H47N5O7Si/c1-25(45)43-35-32-36(41-23-40-35)44(24-42-32)37-34(51-52(7,8)38(2,3)4)33(46)31(50-37)22-49-39(26-12-10-9-11-13-26,27-14-18-29(47-5)19-15-27)28-16-20-30(48-6)21-17-28/h9-21,23-24,31,33-34,37,46H,22H2,1-8H3,(H,40,41,43,45)/t31-,33-,34-,37-/m1/s1

Synonyms: N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine; N6-Acetyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-adenosine

5'-O-DMT-2'-OMe-G(dmf)-3'-O-succinate, TEA salt

Description: 5'-O-DMT-2'-OMe-G(dmf)-3'-O-succinate, TEA salt is a nucleoside analog that has a guanosine (G) base with a 2'-OMe modification and a succinate group at the 3'-position. The TEA (triethylamine) salt form ensures improved solubility and stability in aqueous solutions, making it suitable for biochemical research involving RNA structure and function. This compound is valuable for probing RNA-protein interactions and studying enzymatic processes that involve guanosine derivatives.

CAT: BRP-01222

Molecular Formula: C39H42N6O10 (free acid)

Molecular Weight: 754.80 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N2-dimethylformamide-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine 3'-O-succinate, triethylamine salt; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-methyl-, 3'-(hydrogen butanedioate), triethylamine salt

Related CAS: 143028-80-2 (free base)

N4-Bz-DMT-2'-O-Me-Cr-3'-succinate, TEA salt

Description: N4-Bz-DMT-2'-O-Me-Cr-3'-succinate, TEA salt, a nucleoside derivative, contains a cytosine (C) base modified with a benzoyl (Bz) group at the N4 position and a methyl group (Me) at the 2'-position. The succinate and TEA salt formulation enhances solubility and ease of handling in experimental settings. It is commonly employed in nucleic acid synthesis research to explore the impact of chemical modifications on RNA stability, structure, and function, particularly in the context of RNA-protein interactions.

CAT: BRP-01223

Molecular Formula: C42H41N3O11 (free acid)

Molecular Weight: 763.79 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-O-succinate, triethylamine salt; DMT-2'-O-Me-C(Bz)-3'-succinate, TEA salt

Related CAS: 2940874-28-0 (free base)

DMT-2'-O-Me-Ur-3'-succinate, TEA salt

Description: DMT-2'-O-Me-Ur-3'-succinate, TEA salt is a uridine (U) nucleoside derivative featuring a methyl group (Me) at the 2'-position and a succinate group at the 3'-position, stabilized with TEA salt. It is utilized in biochemical studies to investigate RNA biology and nucleoside chemistry. Its structure allows researchers to explore how modifications at the 2'-position of uridine affect RNA structure, stability, and interactions with proteins, providing insights into cellular processes and potential therapeutic targets.

CAT: BRP-01224

Molecular Formula: C35H36N2O11 (free acid)

Molecular Weight: 660.67 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine-3'-O-succinate, triethylamine salt

Related CAS: 114745-30-1 (free base) ; 1792211-00-7 (TEA salt (1:1))

N2-iBu-DMT-2'-O-Me-Gr-3'-succinate, TEA salt

Description: N2-iBu-DMT-2'-O-Me-Gr-3'-succinate, TEA salt is a nucleoside analog that comprises guanosine (G) with an isobutyl (iBu) group at the N2 position and a methyl group (Me) at the 2'-position, along with a succinate group stabilized by TEA salt. It is employed in biochemical and molecular biology research to study nucleoside modifications and their impact on RNA function. This compound is valuable for exploring guanosine derivatives' roles in RNA metabolism, structure, and enzymatic reactions involved in nucleic acid synthesis and modification.

CAT: BRP-01225

Molecular Formula: C40H43N5O11 (free acid)

Molecular Weight: 769.80 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylguanosine-3'-O-succinate, triethylamine salt; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-(hydrogen butanedioate), triethylamine salt; DMT-2'-O-Me-G(iBu)-3'-succinate, TEA salt

Related CAS: 114745-31-2 (free base)

N6-Bz-DMT-2'-O-Me-Ar-3'-succinate, TEA salt

Description: N6-Bz-DMT-2'-O-Me-Ar-3'-succinate, TEA salt is an adenosine (A) derivative that features a benzoyl (Bz) group at the N6 position and a methyl group (Me) at the 2'-position, with succinate and TEA salt for solubility. It is utilized in biochemical and molecular biology studies to investigate modified nucleosides' effects on RNA structure and function. Researchers use this compound to explore how specific chemical modifications at critical positions of adenosine affect RNA-protein interactions, enzymatic processes, and cellular signaling pathways.

CAT: BRP-01226

Molecular Formula: C43H41N5O8 (free acid)

Molecular Weight: 787.81 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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IUPAC Name: 4-[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-adenosine-3'-O-succinate, triethylamine salt; DMT-2'-O-Me-A(Bz)-3'-succinate, TEA salt

Related CAS: 2940857-85-0 (free base)

5'-O-DMTr-2'-O-MOE-5-Me-C(Bz)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-MOE-5-Me-C(Bz)-3'-O-succinate, TEA salt is a modified nucleoside that contains a cytosine (C) base substituted with a 5-Me-C(Bz) group and a 2'-position methoxyethyl (MOE) modification, with succinate and TEA salt to improve solubility. It is used in synthetic biology and RNA research to investigate nucleoside structure-function relationships and their roles in biological processes. This compound allows researchers to study how specific chemical modifications impact RNA stability, secondary structure formation, and interactions with proteins, advancing our understanding of nucleic acid biochemistry and potential therapeutic applications.

CAT: BRP-01227

Molecular Formula: C45H47N3O12 (free acid)

Molecular Weight: 821.88 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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IUPAC Name: 4-(((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N4-benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-O-succinate, triethylamine salt; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-(hydrogen butanedioate), triethylamine salt

Related CAS: 1536204-26-8 (free base) ; 1536204-27-9 (TEA salt (1:1))

5'-DMT-2'-O-MOE-C(Ac)-3'-succinate, TEA salt

Description: 5'-DMT-2'-O-MOE-C(Ac)-3'-succinate, TEA salt is a nucleoside derivative that features a cytosine (C) base modified with an acetyl (Ac) group at the 2'-position and a succinate group at the 3'-position. The TEA (triethylamine) salt formulation ensures improved solubility and stability in aqueous solutions. This compound is used in biochemical research to study RNA structure and function, particularly in exploring how modifications at specific nucleoside positions affect RNA-protein interactions and enzymatic processes.

CAT: BRP-01228

Molecular Formula: C45H58N4O12

Molecular Weight: 846.97

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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InChIKey: GISCEWMZFVCQKL-WKHDLHBGSA-N

CanonicalSMILES: CCN(CC)CC.CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OC(=O)CCC(=O)O)OCCOC

IUPAC Name: 4-[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C39H43N3O12.C6H15N/c1-25(43)40-32-20-21-42(38(47)41-32)37-36(51-23-22-48-2)35(54-34(46)19-18-33(44)45)31(53-37)24-52-39(26-8-6-5-7-9-26,27-10-14-29(49-3)15-11-27)28-12-16-30(50-4)17-13-28;1-4-7(5-2)6-3/h5-17,20-21,31,35-37H,18-19,22-24H2,1-4H3,(H,44,45)(H,40,41,43,47);4-6H2,1-3H3/t31-,35-,36-,37-;/m1./s1

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-O-succinate, triethylamine salt; Triethylamine 4-(((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoate

5'-O-DMT-2'-O-MOE-U-3'-succinate, TEA salt

Description: 5'-O-DMT-2'-O-MOE-U-3'-succinate, TEA salt is a nucleoside analog that contains a uridine (U) base with a methoxyethyl (MOE) modification at the 2'-position and a succinate group at the 3'-position, stabilized with TEA salt. It is utilized in nucleic acid synthesis and modification studies to investigate the impact of chemical modifications on RNA stability and structure. Researchers use this compound to explore how modifications at the 2'-position of uridine influence RNA function and interactions with proteins.

CAT: BRP-01229

Molecular Formula: C37H40N2O12 (free acid)

Molecular Weight: 704.73 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-(2-methoxyethoxy)oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-uridine 3'-O-succinate, triethylamine salt

5'-O-DMT-2'-O-MOE-A(Bz)-3'-O-succinate, TEA salt

Description: 5'-O-DMT-2'-O-MOE-A(Bz)-3'-O-succinate, TEA salt is an adenosine (A) derivative that features a benzoyl (Bz) group at the 2'-position and a methoxyethyl (MOE) modification at the 2'-position, with a succinate group at the 3'-position and stabilized with TEA salt. It is employed in biochemical research to investigate modified nucleosides' effects on RNA structure, stability, and function. This compound is valuable for studying adenosine derivatives' roles in RNA metabolism, enzymatic processes, and interactions with RNA-binding proteins.

CAT: BRP-01230

Molecular Formula: C45H45N5O11 (free acid)

Molecular Weight: 831.88 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine 3'-O-succinate, triethylamine salt

Related CAS: 444814-78-2 (free base)

5'-O-DMTr-2'-O-TMBTM-C(Bz)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-TMBTM-C(Bz)-3'-O-succinate, TEA salt is a nucleoside derivative that contains a cytosine (C) base modified with a benzoyl (Bz) group at the 2'-position and a TMBTM group at the 2'-position, with a succinate group at the 3'-position and stabilized with TEA salt. It is used in nucleic acid synthesis and modification research to explore the impact of chemical modifications on RNA structure and function. This compound allows researchers to study how specific modifications at critical positions of cytosine influence RNA-protein interactions and enzymatic activities.

CAT: BRP-01231

Molecular Formula: C52H53N3O14S (free acid)

Molecular Weight: 976.06 (free acid)

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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IUPAC Name: 4-(((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-cytidine-3'-O-succinate, triethylamine salt