Nucleosides

2'-O-propargyl-rC(Bz)

Description: 2'-O-propargyl-rC(Bz) is a modified ribonucleoside with a propargyl group attached to the 2'-hydroxyl position of cytidine, and the cytosine base is protected by a benzoyl (Bz) group. These modifications improve the nucleoside's stability and facilitate its incorporation into RNA oligonucleotides. It is especially valuable in biochemical research and therapeutic development, enabling advanced applications such as click chemistry and targeted nucleic acid modifications.

CAT: BRP-00716

CAS: 210096-41-6

Molecular Formula: C19H19N3O6

Molecular Weight: 385.38

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.40±0.1 g/cm3

InChIKey: AZAKCGNNQUSBGN-GFOCRRMGSA-N

CanonicalSMILES: C#CCOC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)CO)O

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C19H19N3O6/c1-2-10-27-16-15(24)13(11-23)28-18(16)22-9-8-14(21-19(22)26)20-17(25)12-6-4-3-5-7-12/h1,3-9,13,15-16,18,23-24H,10-11H2,(H,20,21,25,26)/t13-,15-,16-,18-/m1/s1

Synonyms: Cytidine, N-benzoyl-2'-O-2-propynyl-; N-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; N-Benzoyl-2'-O-2-propyn-1-ylcytidine; N4-Benzoyl-2'-O-propargylcytidine

2'-O-MOE-rC(Ac)

Description: 2'-O-MOE-rC(Ac) is a modified ribonucleoside where a 2'-O-methoxyethyl (MOE) group is attached to the ribose sugar, and the cytosine base is protected by an acetyl (Ac) group. This modification enhances the stability and binding affinity of the ribonucleoside, making it particularly useful in the synthesis of RNA oligonucleotides. It is valuable in various biochemical applications, including antisense therapy and RNA interference, where increased stability and efficient hybridization are crucial.

CAT: BRP-00717

CAS: 2049081-09-4

Molecular Formula: C14H21N3O7

Molecular Weight: 343.34

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.50±0.1 g/cm3

InChIKey: QULXYCXNYGAKCY-OJAKKHQRSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(CO)C(O)C2OCCOC)NC(=O)C

IUPAC Name: N-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C14H21N3O7/c1-8(19)15-10-3-4-17(14(21)16-10)13-12(23-6-5-22-2)11(20)9(7-18)24-13/h3-4,9,11-13,18,20H,5-7H2,1-2H3,(H,15,16,19,21)/t9-,11-,12-,13-/m1/s1

Synonyms: N4-Acetyl-2'-O-(2-methoxyethyl)cytidine

3',5'-O-DMTr-2'-O-Me-rA(Bz)

Description: 3',5'-O-DMTr-2'-O-Me-rA(Bz) is a modified ribonucleoside where dimethoxytrityl (DMTr) groups protect both the 3'- and 5'-hydroxyl positions, a methyl group is attached to the 2'-hydroxyl position, and the adenine base is protected by a benzoyl (Bz) group. This configuration enhances the stability and reactivity of the ribonucleoside, making it suitable for the chemical synthesis of RNA oligonucleotides, particularly in automated solid-phase synthesis.

CAT: BRP-00718

Molecular Formula: C60H55N5O9

Molecular Weight: 990.13

Purity: ≥98% by HPLC

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InChIKey: FKPKMEDKVSDOPK-AJCPUZLQSA-N

IUPAC Name: N-(9-((2R,3R,4R,5R)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C60H55N5O9/c1-67-47-29-21-43(22-30-47)59(41-17-11-7-12-18-41,44-23-31-48(68-2)32-24-44)72-37-51-53(54(71-5)58(73-51)65-39-63-52-55(61-38-62-56(52)65)64-57(66)40-15-9-6-10-16-40)74-60(42-19-13-8-14-20-42,45-25-33-49(69-3)34-26-45)46-27-35-50(70-4)36-28-46/h6-36,38-39,51,53-54,58H,37H2,1-5H3,(H,61,62,64,66)/t51-,53-,54-,58-/m1/s1

5'-O-DMTr-2'-O-Me-rA

Description: 5'-O-DMTr-2'-O-Me-rA is a modified ribonucleoside where the 5'-hydroxyl position is protected by a dimethoxytrityl (DMTr) group and a methyl group is attached to the 2'-hydroxyl position. This combination improves the stability and efficiency of the ribonucleoside during RNA synthesis, facilitating its use in the production of modified RNA molecules for research and therapeutic applications.

CAT: BRP-00719

CAS: 103285-23-0

Molecular Formula: C32H33N5O6

Molecular Weight: 583.65

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.35±0.1 g/cm3

Boiling Point: 796.5±70.0 °C at 760 mmHg

InChIKey: GXRYFFDAEWYIBQ-QWOIFIOOSA-N

CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)N)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O

IUPAC Name: (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-ol

InChI: InChI=1S/C32H33N5O6/c1-39-23-13-9-21(10-14-23)32(20-7-5-4-6-8-20,22-11-15-24(40-2)16-12-22)42-17-25-27(38)28(41-3)31(43-25)37-19-36-26-29(33)34-18-35-30(26)37/h4-16,18-19,25,27-28,31,38H,17H2,1-3H3,(H2,33,34,35)/t25-,27-,28-,31-/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-adenosine; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-; 5-O-(4,4'-dimethoxytrityl)-1-adenin-9-yl-1-deoxy-2-O-methyl-beta-D-ribo-pentofuranose; 5'-ODMT-2'-OMe Adenosine; 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyladenosine

3'-O-DMTr-2'-O-Me-rA(Bz)

Description: 3'-O-DMTr-2'-O-Me-rA(Bz) is a modified ribonucleoside with a dimethoxytrityl (DMTr) group protecting the 3'-hydroxyl position, a methyl group attached to the 2'-hydroxyl position, and the adenine base protected by a benzoyl (Bz) group. These modifications enhance the nucleoside's stability and reactivity, making it useful in the synthesis of RNA oligonucleotides for various biochemical and therapeutic applications.

CAT: BRP-00720

Molecular Formula: C39H37N5O7

Molecular Weight: 687.75

Purity: ≥98% by HPLC

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InChIKey: WEBPCTCQLLDNMM-CJEGOSRCSA-N

IUPAC Name: N-(9-((2R,3R,4R,5R)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C39H37N5O7/c1-47-29-18-14-27(15-19-29)39(26-12-8-5-9-13-26,28-16-20-30(48-2)21-17-28)51-33-31(22-45)50-38(34(33)49-3)44-24-42-32-35(40-23-41-36(32)44)43-37(46)25-10-6-4-7-11-25/h4-21,23-24,31,33-34,38,45H,22H2,1-3H3,(H,40,41,43,46)/t31-,33-,34-,38-/m1/s1

3'-O-TBDMS-2'-O-Me-rC(Ac)

Description: 3'-O-TBDMS-2'-O-Me-rC(Ac) is a modified ribonucleoside where a tert-butyldimethylsilyl (TBDMS) group is attached to the 3'-hydroxyl position, and a methyl group is attached to the 2'-hydroxyl position of cytidine. Additionally, the cytosine base is protected by an acetyl (Ac) group. This modification enhances the stability and reactivity of the ribonucleoside, making it useful for the synthesis of RNA oligonucleotides, particularly in solid-phase synthesis methodologies.

CAT: BRP-00721

CAS: 1345716-50-8

Molecular Formula: C18H31N3O6Si

Molecular Weight: 413.55

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.23±0.1 g/cm3

InChIKey: MZUBOXAFQDGIOI-DTZQCDIJSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O[Si](C)(C)C(C)(C)C)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C18H31N3O6Si/c1-11(23)19-13-8-9-21(17(24)20-13)16-15(25-5)14(12(10-22)26-16)27-28(6,7)18(2,3)4/h8-9,12,14-16,22H,10H2,1-7H3,(H,19,20,23,24)/t12-,14-,15-,16-/m1/s1

Synonyms: Cytidine, N-acetyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyl-; N-Acetyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methylcytidine; N-(1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

3'-O-TBDMS-2'-O-Me-rA(Bz)

Description: 3'-O-TBDMS-2'-O-Me-rA(Bz) is a modified ribonucleoside where a tert-butyldimethylsilyl (TBDMS) group is attached to the 3'-hydroxyl position, and a methyl group is attached to the 2'-hydroxyl position of adenosine. Additionally, the adenine base is protected by a benzoyl (Bz) group. This modification enhances the stability and reactivity of the ribonucleoside, making it useful for the synthesis of RNA oligonucleotides, particularly in solid-phase synthesis methodologies.

CAT: BRP-00722

CAS: 454424-09-0

Molecular Formula: C24H33N5O5Si

Molecular Weight: 499.64

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.28±0.1 g/cm3

InChIKey: ROHHXNDVYNHGRQ-DYVMYPEFSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C24H33N5O5Si/c1-24(2,3)35(5,6)34-18-16(12-30)33-23(19(18)32-4)29-14-27-17-20(25-13-26-21(17)29)28-22(31)15-10-8-7-9-11-15/h7-11,13-14,16,18-19,23,30H,12H2,1-6H3,(H,25,26,28,31)/t16-,18-,19-,23-/m1/s1

Synonyms: Adenosine, N-benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyl-; N-Benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyladenosine; N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

5'-O-DMT-N4-Ac-2'-O-(2-methoxyethyl)cytidine

Description: 5'-O-DMT-N4-Ac-2'-O-(2-methoxyethyl)cytidine is a modified cytidine nucleoside used in oligonucleotide synthesis. It features a cytidine base with an N4-acetyl modification and a 2'-O-(2-methoxyethyl) group attached to the ribose sugar moiety. This modification enhances the stability and specificity of the resulting oligonucleotides, making them valuable tools in various molecular biology applications.

CAT: BRP-00744

CAS: 1345716-47-3

Molecular Formula: C35H39N3O9

Molecular Weight: 645.71

Purity: >98%

Appearance: White to light yellow powder

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Density: 1.27±0.1 g/cm3

InChIKey: RLHWWSNMWZITIE-WXQJYUTRSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(O)C2OCCOC)NC(=O)C

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C35H39N3O9/c1-23(39)36-30-18-19-38(34(41)37-30)33-32(45-21-20-42-2)31(40)29(47-33)22-46-35(24-8-6-5-7-9-24,25-10-14-27(43-3)15-11-25)26-12-16-28(44-4)17-13-26/h5-19,29,31-33,40H,20-22H2,1-4H3,(H,36,37,39,41)/t29-,31-,32-,33-/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)cytidine

5'-O-DMT-N4-Ac-5-Me-2'-O-(2-methoxyethyl)cytidine

Description: 5'-O-DMT-N4-Ac-5-Me-2'-O-(2-methoxyethyl)cytidine is a modified cytidine nucleoside used in oligonucleotide synthesis. This modification further alters the properties of the oligonucleotides, potentially influencing their stability and interactions with target molecules. These modified nucleosides find applications in research areas such as RNA therapeutics, antisense technology, and gene expression studies, where precise control over oligonucleotide properties is essential.

CAT: BRP-00745

Molecular Formula: C36H41N3O9

Molecular Weight: 659.74

Purity: >98%

Appearance: White to light yellow powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: MPYIKKBQDQPMLE-UKNNOAMWSA-N

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C36H41N3O9/c1-23-21-39(35(42)38-33(23)37-24(2)40)34-32(46-20-19-43-3)31(41)30(48-34)22-47-36(25-9-7-6-8-10-25,26-11-15-28(44-4)16-12-26)27-13-17-29(45-5)18-14-27/h6-18,21,30-32,34,41H,19-20,22H2,1-5H3,(H,37,38,40,42)/t30-,31-,32-,34-/m1/s1

Synonyms: N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methylcytidine; N4-Acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methylcytidine; 5'-O-DMTr-2'-O-MOE-5-Me-C(Ac); N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-cytidine

5'-O-DMTr-2'-O-TBS-rU-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-TBS-rU-3'-O-succinate, TEA salt, a modified uridine nucleoside derivative, serves as a building block in RNA synthesis. The dimethoxytrityl (DMTr) and tert-butyldimethylsilyl (TBS) groups protect the 5' and 2' hydroxyl groups, respectively, enabling controlled polymerization. The succinate moiety at the 3' position facilitates conjugation to other molecules, making it valuable for site-specific labeling and conjugation studies in RNA biochemistry.

CAT: BRP-00746

Molecular Formula: C40H48N2O11Si (free acid)

Molecular Weight: 760.90 (free acid)

Purity: >98%

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-uridine-3'-O-succinate, triethylamine salt; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(hydrogen butanedioate) triethylamine salt; Triethylamine 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)-4-oxobutanoate; DMT-2'-O-TBDMS-Ur-3'-succinate, TEA salt; 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-uridine-3'-O-succinate, triethylamine salt

Related CAS: 119702-12-4 (free base)

N6-Bz-5'-O-DMTr-2'-O-TBS-rA-3'-O-succinate, TEA salt

Description: N6-Bz-5'-O-DMTr-2'-O-TBS-rA-3'-O-succinate, TEA salt, an adenine derivative, is crucial for RNA synthesis, offering site-specific modifications. The N6 position of the adenine base is protected with a benzoyl (Bz) group, ensuring controlled reactivity during synthesis. The DMTr and TBS groups protect the 5' and 2' hydroxyl groups, respectively, while the succinate moiety facilitates conjugation reactions, making it suitable for site-specific labeling and conjugation studies in RNA research.

CAT: BRP-00747

Molecular Formula: C48H53N5O10Si (free acid)

Molecular Weight: 888.05 (free acid)

Purity: >98%

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 4-(((2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid, triethylamine salt; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(hydrogen butanedioate), triethylamine salt; N6-Bz-DMT-2'-O-TBDMS-Ar-3'-succinate, TEA salt; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-adenosine-3'-O-succinate, triethylamine salt

Related CAS: 131316-88-6 (free base)

N2-iBu-5'-O-DMTr-2'-O-TBS-rG-3'-O-succinate, TEA salt

Description: N2-iBu-5'-O-DMTr-2'-O-TBS-rG-3'-O-succinate, TEA salt, a guanosine derivative, plays a vital role in RNA synthesis and modification. The isobutyl (iBu) group at the N2 position of the guanine base provides stability and selective reactivity during oligonucleotide assembly. The DMTr and TBS groups protect the 5' and 2' hydroxyl groups, respectively, while the succinate moiety offers a handle for conjugation reactions, enabling versatile applications in RNA research.

CAT: BRP-00748

Molecular Formula: C45H55N5O11Si (free acid)

Molecular Weight: 870.04 (free acid)

Purity: >98%

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 4-(((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid, triethylamine salt; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-, 3'-(hydrogen butanedioate), triethylamine salt; N2-iBu-DMT-2'-O-TBDMS-Gr-3'-succinate, TEA salt; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-guanosine-3'-O-succinate, triethylamine salt

Related CAS: 131289-17-3 (free base)

N4-Ac-5'-O-DMTr-5-Me-2'-O-TBS-rC-3'-O-succinate, TEA salt

Description: N4-Ac-5'-O-DMTr-5-Me-2'-O-TBS-rC-3'-O-succinate, TEA salt, a cytidine derivative, is essential for RNA synthesis, offering precise modifications. The acetyl (Ac) group at the N4 position of the cytosine base provides stability and specific reactivity during oligonucleotide synthesis. The presence of a 5-methyl modification enhances stability and base pairing specificity. The DMTr and TBS groups protect the 5' and 2' hydroxyl groups, respectively, while the succinate moiety facilitates conjugation reactions, enabling tailored functionalization of RNA molecules.

CAT: BRP-00749

Molecular Formula: C43H53N3O11Si (free acid)

Molecular Weight: 815.99 (free acid)

Purity: >98%

Appearance: White to yellow powder

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IUPAC Name: 4-(((2R,3R,4R,5R)-5-(4-acetamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(hydrogen butanedioate), 5-methylcytidine, triethylamine salt

N4-Bz-5'-O-DMTr-5-Me-2'-O-TBS-rC-3'-O-succinate, TEA salt

Description: N4-Bz-5'-O-DMTr-5-Me-2'-O-TBS-rC-3'-O-succinate, TEA salt, a cytidine derivative, features a benzoyl (Bz) group at the N4 position of the cytosine base, providing stability and controlled reactivity. The 5-methyl modification enhances stability and base pairing specificity. The DMTr and TBS groups protect the 5' and 2' hydroxyl groups, respectively, while the succinate moiety offers a handle for conjugation, facilitating tailored functionalization of RNA molecules.

CAT: BRP-00750

Molecular Formula: C48H55N3O11Si (free acid)

Molecular Weight: 878.06 (free acid)

Purity: >98%

Appearance: White to yellow powder

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IUPAC Name: 4-(((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(hydrogen butanedioate), 5-methylcytidine, triethylamine salt

N4-Ac-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt

Description: N4-Ac-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt, a cytidine derivative, is a versatile building block in RNA synthesis, offering precise modifications. The acetyl (Ac) group at the N4 position of the cytosine base provides stability and specific reactivity during oligonucleotide assembly. The DMTr and TBS groups protect the 5' and 2' hydroxyl groups, respectively, while the succinate moiety facilitates conjugation reactions, enabling tailored functionalization of RNA molecules.

CAT: BRP-00751

Molecular Formula: C42H51N3O11Si (free acid)

Molecular Weight: 801.33 (free acid)

Purity: >98%

Appearance: White to yellow powder

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IUPAC Name: 4-[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(hydrogen butanedioate) triethylamine salt; 4-(((2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid triethylamine salt

Related CAS: 2940874-25-7 (free base)

5'-O-DMTr-5-Me-2'-O-TBS-rU-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-5-Me-2'-O-TBS-rU-3'-O-succinate, TEA salt, a modified uridine nucleoside derivative, is crucial for RNA synthesis and modification. The presence of a 5-methyl modification enhances stability and base pairing specificity. The DMTr and TBS groups protect the 5' and 2' hydroxyl groups, respectively, while the succinate moiety facilitates conjugation reactions, making it suitable for site-specific labeling and conjugation studies in RNA biochemistry.

CAT: BRP-00752

Molecular Formula: C41H50N2O11Si (free acid)

Molecular Weight: 774.94 (free acid)

Purity: >98%

Appearance: White to yellow powder

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IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-5-methyluridine-3'-O-succinate, triethylamine salt; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3'-(hydrogen butanedioate), triethylamine salt

Related CAS: 159639-79-9 (free base)

N4-Bz-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt

Description: N4-Bz-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt is a cytidine derivative used in RNA synthesis, featuring a benzoyl (Bz) group at the N4 position of the cytosine base, which provides stability and controlled reactivity during oligonucleotide assembly. The 5' and 2' hydroxyl groups are protected by dimethoxytrityl (DMTr) and tert-butyldimethylsilyl (TBS) groups, respectively. Additionally, the succinate moiety at the 3' end facilitates conjugation reactions, making it suitable for site-specific labeling and conjugation studies in RNA research. The TEA (triethylammonium) salt form enhances solubility and stability for practical use in biochemical applications.

CAT: BRP-00753

Molecular Formula: C47H53N3O11Si (free acid)

Molecular Weight: 864.04 (free acid)

Purity: >98%

Appearance: White to yellow powder

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IUPAC Name: 4-[(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(hydrogen butanedioate) triethylamine salt; 4-(((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid triethylamine salt

Related CAS: 131289-16-2 (free base)

2-Amino-6-chloro-9-(3'-O-methyl-beta-D-ribofuranosyl)-9H-purine

Description: Used for further modified purine nucleoside synthesis.

CAT: BRP-00759

Molecular Formula: C11H14ClN5O4

Molecular Weight: 315.71

Purity: ≥98%

Appearance: White or off-white solid

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Storage: Store at 2-8 °C

InChIKey: PMVUXOVFDRGLHZ-KQYNXXCUSA-N

CanonicalSMILES: COC1C(OC(C1O)N2C=NC3=C2N=C(N=C3Cl)N)CO

IUPAC Name: (2R,3R,4S,5R)-2-(2-amino-6-chloropurin-9-yl)-5-(hydroxymethyl)-4-methoxyoxolan-3-ol

InChI: InChI=1S/C11H14ClN5O4/c1-20-7-4(2-18)21-10(6(7)19)17-3-14-5-8(12)15-11(13)16-9(5)17/h3-4,6-7,10,18-19H,2H2,1H3,(H2,13,15,16)/t4-,6-,7-,10-/m1/s1

Synonyms: 3'-O-methyl-2-amino-6-chloro-6-deamino-adenosine; (2R,3R,4S,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol

2'-O-Propargyl-5-methyl uridine

Description: It is used for the synthesis of 2'-modified nucleoside phosphoramidites and corresponding modified RNA oligomers.

CAT: BRP-00760

CAS: 860640-50-2

Molecular Formula: C13H16N2O6

Molecular Weight: 296.28

Purity: ≥97%

Appearance: White or off-white solid

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Storage: Store at 2-8 °C

Density: 1.46±0.1 g/cm3

InChIKey: BSRONJSLOYHEHY-DNRKLUKYSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)OCC#C

IUPAC Name: 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C13H16N2O6/c1-3-4-20-10-9(17)8(6-16)21-12(10)15-5-7(2)11(18)14-13(15)19/h1,5,8-10,12,16-17H,4,6H2,2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1

Synonyms: 2'-O-Propargyl-5-methyluridine; 5-Methyl-2'-O-2-propyn-1-yluridine; Uridine, 5-methyl-2'-O-2-propynyl-; Uridine, 5-methyl-2'-O-2-propyn-1-yl-; 1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-5-methyluridine

Description: It is used for the synthesis of 2'-modified nucleoside phosphoramidites and corresponding modified RNA oligomers. This modified nucleoside exhibits the exceptional ability to integrate into RNA molecules, thereby facilitating the exploration of RNA's intricate structure and functionality.

CAT: BRP-00761

CAS: 860640-56-8

Molecular Formula: C34H34N2O8

Molecular Weight: 598.64

Purity: ≥98%

Appearance: White or off-white solid

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Storage: Store at 2-8 °C

Density: 1.34±0.1 g/cm3

InChIKey: OEAZBXNAASQUGJ-PBAMLIMUSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OCC#C

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-prop-2-ynoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C34H34N2O8/c1-5-19-42-30-29(37)28(44-32(30)36-20-22(2)31(38)35-33(36)39)21-43-34(23-9-7-6-8-10-23,24-11-15-26(40-3)16-12-24)25-13-17-27(41-4)18-14-25/h1,6-18,20,28-30,32,37H,19,21H2,2-4H3,(H,35,38,39)/t28-,29-,30-,32-/m1/s1

Synonyms: 5-O-(4,4'-dimethoxytrityl)-1-deoxy-2-O-prop-2-ynyl-1-thymin-1-yl-beta-D-ribo-pentofuranose; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-2-propyn-1-yluridine; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-2-propynyl-; 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

2'-O-propargyl-rC(Bz)

2'-O-MOE-rC(Ac)

3',5'-O-DMTr-2'-O-Me-rA(Bz)

5'-O-DMTr-2'-O-Me-rA

3'-O-DMTr-2'-O-Me-rA(Bz)

3'-O-TBDMS-2'-O-Me-rC(Ac)

3'-O-TBDMS-2'-O-Me-rA(Bz)

5'-O-DMT-N4-Ac-2'-O-(2-methoxyethyl)cytidine

5'-O-DMT-N4-Ac-5-Me-2'-O-(2-methoxyethyl)cytidine

5'-O-DMTr-2'-O-TBS-rU-3'-O-succinate, TEA salt

N6-Bz-5'-O-DMTr-2'-O-TBS-rA-3'-O-succinate, TEA salt

N2-iBu-5'-O-DMTr-2'-O-TBS-rG-3'-O-succinate, TEA salt

N4-Ac-5'-O-DMTr-5-Me-2'-O-TBS-rC-3'-O-succinate, TEA salt

N4-Bz-5'-O-DMTr-5-Me-2'-O-TBS-rC-3'-O-succinate, TEA salt

N4-Ac-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt

5'-O-DMTr-5-Me-2'-O-TBS-rU-3'-O-succinate, TEA salt

N4-Bz-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt

2-Amino-6-chloro-9-(3'-O-methyl-beta-D-ribofuranosyl)-9H-purine

2'-O-Propargyl-5-methyl uridine

5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-5-methyluridine

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