What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - RNA / BOC Sciences

5'-O-DMTr-2'-O-TMBTM-G(iBu)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-TMBTM-G(iBu)-3'-O-succinate, TEA salt is a guanosine (G) nucleoside analog that is modified with an isobutyl (iBu) group at the 2'-position and a TMBTM group at the 2'-position, with a succinate group at the 3'-position and stabilized with TEA salt. It is utilized in biochemical and molecular biology research to investigate modified nucleosides' effects on RNA structure and function. Researchers use this compound to explore how modifications at the 2'-position of guanosine impact RNA stability, enzymatic reactions, and interactions with RNA-binding proteins.

CAT: BRP-01232

Molecular Formula: C50H55N5O14S (free acid)

Molecular Weight: 982.07 (free acid)

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-guanosine-3'-O-succinate, triethylamine salt

5'-O-DMTr-2'-O-TMBTM-U-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-TMBTM-U-3'-O-succinate, TEA salt is a uridine (U) nucleoside derivative that features a TMBTM modification at the 2'-position and a succinate group at the 3'-position, stabilized with TEA salt. It is used in nucleic acid research to study RNA modifications and their impact on RNA biology. This compound allows researchers to investigate how modifications at the 2'-position of uridine affect RNA structure, stability, and interactions with proteins, providing insights into cellular processes and potential therapeutic applications.

CAT: BRP-01233

Molecular Formula: C45H48N2O14S (free acid)

Molecular Weight: 872.94 (free acid)

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at 2-8 °C

IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-uridine-3'-O-succinate, triethylamine salt

5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-O-succinate, TEA salt is an adenosine (A) derivative that contains a benzoyl (Bz) group at the 2'-position and a TMBTM modification at the 2'-position, with a succinate group at the 3'-position and stabilized with TEA salt. It is employed in biochemical and molecular biology research to study nucleoside modifications and their impact on RNA function. This compound allows researchers to explore how modifications at the 2'-position of adenosine influence RNA metabolism, structure, and interactions with proteins involved in RNA processing and regulation.

CAT: BRP-01234

Molecular Formula: C53H53N5O13S (free acid)

Molecular Weight: 1000.09 (free acid)

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-adenosine-3'-O-succinate, triethylamine salt

5'-O-DMTr-2'-O-TOM-U succinate

Description: 5'-O-DMTr-2'-O-TOM-U succinate is a nucleoside derivative that features a uridine (U) base with a TOM (2'-O-TOM) modification at the 2'-position and a succinate group at the 3'-position. It is used in nucleic acid synthesis and modification studies to investigate the role of modified nucleosides in RNA structure and function. The succinate modification aids in enhancing solubility and stability in biochemical assays, making it suitable for studying RNA-protein interactions and enzymatic activities involved in RNA metabolism.

CAT: BRP-01235

Molecular Formula: C44H56N2O12Si

Molecular Weight: 833.02

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: TWSPHFOHWURPEH-GLONBZIJSA-N

IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

InChI: InChI=1S/C44H56N2O12Si/c1-28(2)59(29(3)4,30(5)6)56-27-54-41-40(58-39(50)23-22-38(48)49)36(57-42(41)46-25-24-37(47)45-43(46)51)26-55-44(31-12-10-9-11-13-31,32-14-18-34(52-7)19-15-32)33-16-20-35(53-8)21-17-33/h9-21,24-25,28-30,36,40-42H,22-23,26-27H2,1-8H3,(H,48,49)(H,45,47,51)/t36-,40-,41-,42-/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-uridine-succinate; 5'-O-DMTr-2'-O-TOM-U-3'-O-succinate

5'-O-DMTr-2'-O-TOM-C(Ac) succinate

Description: 5'-O-DMTr-2'-O-TOM-C(Ac) succinate is a cytosine (C) nucleoside analog that contains an acetyl (Ac) group at the 2'-position and a TOM (2'-O-TOM) modification at the 2'-position, with a succinate group at the 3'-position. It is utilized in biochemical research to explore modified nucleosides' effects on RNA stability and function. This compound allows researchers to investigate how modifications at the 2'-position of cytosine influence RNA structure, enzymatic processes, and interactions with proteins, advancing our understanding of nucleic acid biochemistry and potential therapeutic applications.

CAT: BRP-01236

Molecular Formula: C46H59N3O12Si

Molecular Weight: 874.07

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: AQUZVAWRHRMGSV-LAYMWRTISA-N

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

InChI: InChI=1S/C46H59N3O12Si/c1-29(2)62(30(3)4,31(5)6)59-28-57-43-42(61-41(53)24-23-40(51)52)38(60-44(43)49-26-25-39(47-32(7)50)48-45(49)54)27-58-46(33-13-11-10-12-14-33,34-15-19-36(55-8)20-16-34)35-17-21-37(56-9)22-18-35/h10-22,25-26,29-31,38,42-44H,23-24,27-28H2,1-9H3,(H,51,52)(H,47,48,50,54)/t38-,42-,43-,44-/m1/s1

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-cytidine-succinate; 5'-O-DMTr-2'-O-TOM-C(Ac)-3'-O-succinate

5'-O-DMTr-2'-O-TOM-A(Ac) succinate

Description: 5'-O-DMTr-2'-O-TOM-A(Ac) succinate is an adenosine (A) nucleoside derivative featuring an acetyl (Ac) group at the 2'-position and a TOM (2'-O-TOM) modification at the 2'-position, with a succinate group at the 3'-position. This derivative is used in nucleic acid research to study RNA modifications and their impact on RNA structure and function. It allows researchers to explore how modifications at specific positions of adenosine affect RNA stability, enzymatic processes, and interactions with RNA-binding proteins.

CAT: BRP-01237

Molecular Formula: C47H59N5O11Si

Molecular Weight: 898.10

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: BWTSLHAPYYEBNJ-LSWBLBMOSA-N

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(6-acetamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

InChI: InChI=1S/C47H59N5O11Si/c1-29(2)64(30(3)4,31(5)6)61-28-59-43-42(63-40(56)24-23-39(54)55)38(62-46(43)52-27-50-41-44(51-32(7)53)48-26-49-45(41)52)25-60-47(33-13-11-10-12-14-33,34-15-19-36(57-8)20-16-34)35-17-21-37(58-9)22-18-35/h10-22,26-27,29-31,38,42-43,46H,23-25,28H2,1-9H3,(H,54,55)(H,48,49,51,53)/t38-,42-,43-,46-/m1/s1

Synonyms: N6-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-adenosine-succinate; 5'-O-DMTr-2'-O-TOM-A(Ac)-3'-O-succinate

5'-O-DMTr-2'-O-TOM-G(Ac) succinate

Description: 5'-O-DMTr-2'-O-TOM-G(Ac) succinate is a guanosine (G) nucleoside analog that contains an acetyl (Ac) group at the 2'-position and a TOM (2'-O-TOM) modification at the 2'-position, with a succinate group at the 3'-position. It is employed in biochemical and molecular biology research to investigate modified nucleosides' effects on RNA structure and function. Researchers use this compound to explore how modifications at the 2'-position of guanosine influence RNA stability, enzymatic reactions, and interactions with RNA-binding proteins.

CAT: BRP-01238

Molecular Formula: C47H59N5O12Si

Molecular Weight: 914.10

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: RJLDLOKSNHEKQI-LRZYOCIQSA-N

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

InChI: InChI=1S/C47H59N5O12Si/c1-28(2)65(29(3)4,30(5)6)62-27-60-42-41(64-39(56)24-23-38(54)55)37(63-45(42)52-26-48-40-43(52)50-46(49-31(7)53)51-44(40)57)25-61-47(32-13-11-10-12-14-32,33-15-19-35(58-8)20-16-33)34-17-21-36(59-9)22-18-34/h10-22,26,28-30,37,41-42,45H,23-25,27H2,1-9H3,(H,54,55)(H2,49,50,51,53,57)/t37-,41-,42-,45-/m1/s1

Synonyms: N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-guanosine-succinate; 5'-O-DMTr-2'-O-TOM-G(Ac)-3'-O-succinate

Abasic Succinate

Description: Abasic Succinate is a nucleoside analog where the nucleobase is absent (abasic), with a succinate group attached. Abasic nucleosides are used in nucleic acid research as controls or reference compounds to study the role of specific bases in DNA or RNA structure, function, and interactions with enzymes or proteins.

CAT: BRP-01239

CAS: 1428324-58-6

Molecular Formula: C30H32O8

Molecular Weight: 520.58

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

InChIKey: PURLJYSNZCUYOW-RRPNLBNLSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(CCO4)OC(=O)CCC(=O)O

IUPAC Name: 4-[(2R,3S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl]oxy-4-oxobutanoic acid

InChI: InChI=1S/C30H32O8/c1-34-24-12-8-22(9-13-24)30(21-6-4-3-5-7-21,23-10-14-25(35-2)15-11-23)37-20-27-26(18-19-36-27)38-29(33)17-16-28(31)32/h3-15,26-27H,16-20H2,1-2H3,(H,31,32)/t26-,27+/m0/s1

Synonyms: 4-(((2R,3S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

5'-O-DMTr-C(Ac)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-C(Ac)-3'-O-succinate, TEA salt is a nucleoside derivative that features a cytosine (C) base modified with an acetyl (Ac) group at the 3'-position and a succinate group at the 3'-position, stabilized with TEA salt. It is employed in biochemical and molecular biology research to study nucleoside modifications and their effects on RNA function. This compound allows researchers to investigate how modifications at the 3'-position of cytosine influence RNA metabolism, structure, and interactions with proteins involved in RNA processing and regulation.

CAT: BRP-01240

Molecular Formula: C36H37N3O11 (free acid)

Molecular Weight: 687.70 (free acid)

Purity: ≥95% by HPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-(((2R,3S,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-cytidine 3'-O-succinate, triethylamine salt

2'-O-Allylcytidine

Description: 2'-O-Allylcytidine is a modified nucleoside where the ribose sugar has an allyl group attached at the 2' position. This modification is used in the synthesis of RNA with altered properties, aiding in the study of RNA structure, function, and interactions. It is valuable in research applications, including the development of novel therapeutic RNA molecules and the investigation of RNA-based mechanisms.

CAT: BRP-01257

CAS: 133766-25-3

Molecular Formula: C12H17N3O5

Molecular Weight: 283.28

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Density: 1.53±0.1 g/cm3

Boiling Point: 526.0±60.0 °C at 760 mmHg

InChIKey: SGODVCJEFNCZPV-QCNRFFRDSA-N

CanonicalSMILES: C=CCOC1C(C(OC1N2C=CC(=NC2=O)N)CO)O

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-enoxyoxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C12H17N3O5/c1-2-5-19-10-9(17)7(6-16)20-11(10)15-4-3-8(13)14-12(15)18/h2-4,7,9-11,16-17H,1,5-6H2,(H2,13,14,18)/t7-,9-,10-,11-/m1/s1

Synonyms: 2'-(O-allyl) Cytidine; 2'-O-2-Propen-1-ylcytidine; Cytidine, 2'-O-2-propenyl-; 2'-Allylcytidine

5'-DMT-2'-tBDSilyl Adenosine (n-PAC)

Description: 5'-DMT-2'-tBDSilyl Adenosine (n-PAC) is a chemical reagent used in oligonucleotide synthesis. It features an adenosine nucleoside modified with a 5'-DMT (dimethoxytrityl) group for 5' hydroxyl protection and a 2'-tBDSilyl (tert-butyldimethylsilyl) group for 2' hydroxyl protection. Additionally, the N6 position of adenosine is protected by a PAC (phenoxyacetyl) group. These protective modifications prevent side reactions during the sequential assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise oligonucleotide production. This reagent is crucial for various applications in molecular biology, genetic research, and therapeutic development.

CAT: BRP-01306

CAS: 121058-83-1

Molecular Formula: C45H51N5O8Si

Molecular Weight: 818.00

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Density: 1.23±0.1 g/cm3

InChIKey: QGHUBPNLGMARKQ-DQZBACKDSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]purin-6-yl]-2-phenoxyacetamide

InChI: InChI=1S/C45H51N5O8Si/c1-44(2,3)59(6,7)58-40-39(52)36(57-43(40)50-29-48-38-41(46-28-47-42(38)50)49-37(51)27-55-35-16-12-9-13-17-35)26-56-45(30-14-10-8-11-15-30,31-18-22-33(53-4)23-19-31)32-20-24-34(54-5)25-21-32/h8-25,28-29,36,39-40,43,52H,26-27H2,1-7H3,(H,46,47,49,51)/t36-,39-,40-,43-/m1/s1

Synonyms: N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)-2-phenoxyacetamide; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-phenoxyacetyl)adenosine; N6-Pac-5'-O-DMT-2'-O-TBDMS-rA; 5'-O-(dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N6-phenoxyacetyladenosine

5'-DMT-2'-tBDSilyl Cytidine (n-PAC)

Description: 5'-DMT-2'-tBDSilyl Cytidine (n-PAC) is a specialized reagent used in the synthesis of oligonucleotides. It consists of a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group for protecting the 5' hydroxyl position and a 2'-tBDSilyl (tert-butyldimethylsilyl) group for protecting the 2' hydroxyl position. Additionally, the amino group at the N4 position of cytidine is protected by a PAC (phenoxyacetyl) group. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and accurate oligonucleotide production. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01307

CAS: 259144-71-3

Molecular Formula: C44H51N3O9Si

Molecular Weight: 793.98

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Density: 1.19±0.1 g/cm3

InChIKey: AEVPUWXDGCKYTH-OGEJDOPKSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(O)C2O[Si](C)(C)C(C)(C)C)NC(=O)COC=6C=CC=CC6

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-phenoxyacetamide

InChI: InChI=1S/C44H51N3O9Si/c1-43(2,3)57(6,7)56-40-39(49)36(55-41(40)47-27-26-37(46-42(47)50)45-38(48)29-53-35-16-12-9-13-17-35)28-54-44(30-14-10-8-11-15-30,31-18-22-33(51-4)23-19-31)32-20-24-34(52-5)25-21-32/h8-27,36,39-41,49H,28-29H2,1-7H3,(H,45,46,48,50)/t36-,39-,40-,41-/m1/s1

Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-phenoxyacetyl)cytidine; Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(phenoxyacetyl)-; 5'-O-DMT-2'-O-TBDMS-rC(Pac)

5'-DMT-2'-tBDSilyl Guanosine (n-PAC)

Description: 5'-DMT-2'-tBDSilyl Guanosine (n-PAC) is a specialized reagent used in the synthesis of oligonucleotides. It features a guanosine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and a 2'-tBDSilyl (tert-butyldimethylsilyl) group to protect the 2' hydroxyl position. Additionally, the amino group at the N2 position of guanosine is protected by a PAC (phenoxyacetyl) group. These protective modifications prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and accurate oligonucleotide production. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01308

CAS: 121058-84-2

Molecular Formula: C45H51N5O9Si

Molecular Weight: 834.01

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Density: 1.26±0.1 g/cm3

InChIKey: XPYPOARJDHWYJZ-AEGBRLROSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C2N=C(NC3=O)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-phenoxyacetamide

InChI: InChI=1S/C45H51N5O9Si/c1-44(2,3)60(6,7)59-39-38(52)35(58-42(39)50-28-46-37-40(50)48-43(49-41(37)53)47-36(51)27-56-34-16-12-9-13-17-34)26-57-45(29-14-10-8-11-15-29,30-18-22-32(54-4)23-19-30)31-20-24-33(55-5)25-21-31/h8-25,28,35,38-39,42,52H,26-27H2,1-7H3,(H2,47,48,49,51,53)/t35-,38-,39-,42-/m1/s1

Synonyms: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxyacetamide; N-Pac-5'-O-DMT-2'-O-TBDMS-rG; 5'-O-DMT-2'-O-TBDMS-rG(Pac); 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-phenoxyacetyl)guanosine; 5'-O-(dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N2-phenoxyacetylguanosine

5'-DMT-2'-tBDSilyl Adenosine (n,n-dibz)

Description: 5'-DMT-2'-tBDSilyl Adenosine (n,n-dibz) is a specialized reagent used in the chemical synthesis of oligonucleotides. This compound consists of an adenosine nucleoside that is modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and a 2'-tBDSilyl (tert-butyldimethylsilyl) group to protect the 2' hydroxyl position. Additionally, the amino groups at the N6 position of adenosine are protected by dibenzoyl (n,n-dibz) groups. These protective groups are essential for preventing unwanted side reactions during the sequential assembly of nucleotide chains in automated DNA or RNA synthesis, thereby ensuring efficient and precise oligonucleotide production. This reagent is crucial for various applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01309

CAS: 200284-75-9

Molecular Formula: C51H53N5O8Si

Molecular Weight: 892.08

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Density: 1.22±0.1 g/cm3

Boiling Point: 939.1±75.0 °C at 760 mmHg

InChIKey: VHDQKLHGBANZKX-QGBKNRJASA-N

CanonicalSMILES: O=C(C=1C=CC=CC1)N(C(=O)C=2C=CC=CC2)C=3N=CN=C4C3N=CN4C5OC(COC(C=6C=CC=CC6)(C7=CC=C(OC)C=C7)C8=CC=C(OC)C=C8)C(O)C5O[Si](C)(C)C(C)(C)C

IUPAC Name: N-benzoyl-N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C51H53N5O8Si/c1-50(2,3)65(6,7)64-44-43(57)41(31-62-51(36-21-15-10-16-22-36,37-23-27-39(60-4)28-24-37)38-25-29-40(61-5)30-26-38)63-49(44)55-33-54-42-45(55)52-32-53-46(42)56(47(58)34-17-11-8-12-18-34)48(59)35-19-13-9-14-20-35/h8-30,32-33,41,43-44,49,57H,31H2,1-7H3/t41-,43-,44-,49-/m1/s1

Synonyms: Adenosine, N,N-dibenzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 2'-O-t-Butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-N6-dibenzoyladenosine

5'-DMT-5-Propynyl-2'-(O-Methyl) Cytidine (n-bz)

Description: 5'-DMT-5-Propynyl-2'-(O-Methyl) Cytidine (n-bz) is a specialized reagent used in oligonucleotide synthesis. It features a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group for protecting the 5' hydroxyl position, a 5-propynyl group on the cytosine ring, and a 2'-(O-Methyl) group for protecting the 2' hydroxyl position. Additionally, the N4 amino group is protected by a benzoyl (n-bz) group. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is crucial for applications in molecular biology, genetic research, and nucleic acid-based therapeutics development.

CAT: BRP-01310

Molecular Formula: C41H39N3O8

Molecular Weight: 701.76

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InChIKey: CJDAMOMLUIMTME-LZURGKRNSA-N

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-5-(prop-1-yn-1-yl)-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C41H39N3O8/c1-5-12-28-25-44(40(47)43-37(28)42-38(46)27-13-8-6-9-14-27)39-36(50-4)35(45)34(52-39)26-51-41(29-15-10-7-11-16-29,30-17-21-32(48-2)22-18-30)31-19-23-33(49-3)24-20-31/h6-11,13-25,34-36,39,45H,26H2,1-4H3,(H,42,43,46,47)/t34-,35-,36-,39-/m1/s1

Synonyms: 5'-DMT-5-Propynyl-2'-O-Me-C(Bz)

5'-DMT-2,6-diamino purine riboside (n6,n6-dmf) (n2-ibu)

Description: 5'-DMT-2,6-Diamino Purine Riboside (N6,N6-DMF) (N2-ibu) is a specialized reagent used in oligonucleotide synthesis. It consists of a purine riboside nucleoside modified with a 5'-DMT (dimethoxytrityl) group for protecting the 5' hydroxyl position, dimethylformamidine (DMF) groups protecting the N6 amino groups, and an isobutyryl (ibu) group protecting the N2 position. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01311

Molecular Formula: C38H43N7O7

Molecular Weight: 709.79

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InChIKey: VPXSLKLNUOULQH-BEGXHNNXSA-N

IUPAC Name: N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-6-(((dimethylamino)methylene)amino)-9H-purin-2-yl)isobutyramide

InChI: InChI=1S/C38H43N7O7/c1-23(2)35(48)43-37-41-33(40-21-44(3)4)30-34(42-37)45(22-39-30)36-32(47)31(46)29(52-36)20-51-38(24-10-8-7-9-11-24,25-12-16-27(49-5)17-13-25)26-14-18-28(50-6)19-15-26/h7-19,21-23,29,31-32,36,46-47H,20H2,1-6H3,(H,41,42,43,48)/t29-,31-,32-,36-/m1/s1

Synonyms: 2-Amino-5'-O-(dimethoxytrityl)-N6-(dimethylaminomethylidene)-N2-isobutyryl-adenosine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2-[(2-methyl-1-oxopropyl)amino]adenosine; 5'-DMT-N2-amino-ibu rA(N6-DMF)

5'-DMT-8-Bromo Adenosine (n,n-dibuf)

Description: 5'-DMT-8-Bromo Adenosine (N,N-dibuf) is a specialized reagent used in the synthesis of oligonucleotides. It consists of an adenosine nucleoside modified with an 8-bromo group on the adenine base, a 5'-DMT (dimethoxytrityl) group protecting the 5' hydroxyl position, and N,N-dibutyryl groups protecting the amino groups at the N6 position. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is crucial for various applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01312

CAS: 197712-18-8

Molecular Formula: C40H47BrN6O6

Molecular Weight: 787.74

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Density: 1.36±0.1 g/cm3

Boiling Point: 881.6±75.0 °C at 760 mmHg

InChIKey: IRILBDUSCUMPSP-NFXQKKKASA-N

CanonicalSMILES: BrC1=NC=2C(=NC=NC2N1C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(O)C3O)N=CN(CCCC)CCCC

IUPAC Name: N'-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-8-bromo-9H-purin-6-yl)-N,N-dibutylformimidamide

InChI: InChI=1S/C40H47BrN6O6/c1-5-7-22-46(23-8-6-2)26-44-36-33-37(43-25-42-36)47(39(41)45-33)38-35(49)34(48)32(53-38)24-52-40(27-12-10-9-11-13-27,28-14-18-30(50-3)19-15-28)29-16-20-31(51-4)21-17-29/h9-21,25-26,32,34-35,38,48-49H,5-8,22-24H2,1-4H3/t32-,34-,35-,38-/m1/s1

Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-N-[(dibutylamino)methylene]-

5'-DMT-5-Propynyl Cytidine (n-bz)

Description: 5'-DMT-5-Propynyl Cytidine (n-bz) is a specialized reagent used in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position, a 5-propynyl group on the cytosine ring, and a benzoyl (n-bz) group protecting the N4 amino group. These protective groups are essential for preventing unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is critical for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01313

Molecular Formula: C40H37N3O8

Molecular Weight: 687.74

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InChIKey: IBWXYBVVQWPUCS-UYHDOTGISA-N

IUPAC Name: N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-5-(prop-1-yn-1-yl)-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C40H37N3O8/c1-4-11-27-24-43(39(47)42-36(27)41-37(46)26-12-7-5-8-13-26)38-35(45)34(44)33(51-38)25-50-40(28-14-9-6-10-15-28,29-16-20-31(48-2)21-17-29)30-18-22-32(49-3)23-19-30/h5-10,12-24,33-35,38,44-45H,25H2,1-3H3,(H,41,42,46,47)/t33-,34-,35-,38-/m1/s1

Synonyms: 5'-DMT-5-Propynyl-C(Bz)

5'-DMT Adenosine (N6-Fmoc)

Description: 5'-DMT Adenosine (N6-Fmoc) is a specialized reagent used in the synthesis of oligonucleotides. It consists of an adenosine nucleoside that has been modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and an N6-Fmoc (9-fluorenylmethyloxycarbonyl) group protecting the N6 amino group. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01314

Molecular Formula: C46H41N5O8

Molecular Weight: 791.85

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InChIKey: IXEUDLDKQXKANT-FOQJVDBMSA-N

IUPAC Name: (9H-fluoren-9-yl)methyl (9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

InChI: InChI=1S/C46H41N5O8/c1-55-31-20-16-29(17-21-31)46(28-10-4-3-5-11-28,30-18-22-32(56-2)23-19-30)58-25-38-40(52)41(53)44(59-38)51-27-49-39-42(47-26-48-43(39)51)50-45(54)57-24-37-35-14-8-6-12-33(35)34-13-7-9-15-36(34)37/h3-23,26-27,37-38,40-41,44,52-53H,24-25H2,1-2H3,(H,47,48,50,54)/t38-,40-,41-,44-/m1/s1

Synonyms: N6-Fmoc-5'-O-DMT-Adenosine

5'-DMT Cytidine (N4-Fmoc)

Description: 5'-DMT Cytidine (N4-Fmoc) is a specialized reagent used in the synthesis of oligonucleotides. It features a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and an N4-Fmoc (9-fluorenylmethyloxycarbonyl) group protecting the N4 amino group. These protective groups are crucial for preventing unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01315

Molecular Formula: C45H41N3O9

Molecular Weight: 767.82

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InChIKey: NHPZYWACOHOCQC-QIRDGMKKSA-N

IUPAC Name: (9H-fluoren-9-yl)methyl (1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

InChI: InChI=1S/C45H41N3O9/c1-53-31-20-16-29(17-21-31)45(28-10-4-3-5-11-28,30-18-22-32(54-2)23-19-30)56-27-38-40(49)41(50)42(57-38)48-25-24-39(46-43(48)51)47-44(52)55-26-37-35-14-8-6-12-33(35)34-13-7-9-15-36(34)37/h3-25,37-38,40-42,49-50H,26-27H2,1-2H3,(H,46,47,51,52)/t38-,40+,41+,42-/m1/s1

Synonyms: N4-Fmoc-5'-O-DMT-cytidine