What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - RNA / BOC Sciences

N4-Ac-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt

Description: N4-Ac-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt, a cytidine derivative, is a versatile building block in RNA synthesis, offering precise modifications. The acetyl (Ac) group at the N4 position of the cytosine base provides stability and specific reactivity during oligonucleotide assembly. The DMTr and TBS groups protect the 5' and 2' hydroxyl groups, respectively, while the succinate moiety facilitates conjugation reactions, enabling tailored functionalization of RNA molecules.

CAT: BRP-00751

Molecular Formula: C42H51N3O11Si (free acid)

Molecular Weight: 801.33 (free acid)

Purity: >98%

Appearance: White to yellow powder

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IUPAC Name: 4-[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(hydrogen butanedioate) triethylamine salt; 4-(((2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid triethylamine salt

Related CAS: 2940874-25-7 (free base)

5'-O-DMTr-5-Me-2'-O-TBS-rU-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-5-Me-2'-O-TBS-rU-3'-O-succinate, TEA salt, a modified uridine nucleoside derivative, is crucial for RNA synthesis and modification. The presence of a 5-methyl modification enhances stability and base pairing specificity. The DMTr and TBS groups protect the 5' and 2' hydroxyl groups, respectively, while the succinate moiety facilitates conjugation reactions, making it suitable for site-specific labeling and conjugation studies in RNA biochemistry.

CAT: BRP-00752

Molecular Formula: C41H50N2O11Si (free acid)

Molecular Weight: 774.94 (free acid)

Purity: >98%

Appearance: White to yellow powder

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IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-5-methyluridine-3'-O-succinate, triethylamine salt; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3'-(hydrogen butanedioate), triethylamine salt

Related CAS: 159639-79-9 (free base)

N4-Bz-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt

Description: N4-Bz-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate, TEA salt is a cytidine derivative used in RNA synthesis, featuring a benzoyl (Bz) group at the N4 position of the cytosine base, which provides stability and controlled reactivity during oligonucleotide assembly. The 5' and 2' hydroxyl groups are protected by dimethoxytrityl (DMTr) and tert-butyldimethylsilyl (TBS) groups, respectively. Additionally, the succinate moiety at the 3' end facilitates conjugation reactions, making it suitable for site-specific labeling and conjugation studies in RNA research. The TEA (triethylammonium) salt form enhances solubility and stability for practical use in biochemical applications.

CAT: BRP-00753

Molecular Formula: C47H53N3O11Si (free acid)

Molecular Weight: 864.04 (free acid)

Purity: >98%

Appearance: White to yellow powder

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IUPAC Name: 4-[(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(hydrogen butanedioate) triethylamine salt; 4-(((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid triethylamine salt

Related CAS: 131289-16-2 (free base)

2-Amino-6-chloro-9-(3'-O-methyl-beta-D-ribofuranosyl)-9H-purine

Description: Used for further modified purine nucleoside synthesis.

CAT: BRP-00759

Molecular Formula: C11H14ClN5O4

Molecular Weight: 315.71

Purity: ≥98%

Appearance: White or off-white solid

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Storage: Store at 2-8 °C

InChIKey: PMVUXOVFDRGLHZ-KQYNXXCUSA-N

CanonicalSMILES: COC1C(OC(C1O)N2C=NC3=C2N=C(N=C3Cl)N)CO

IUPAC Name: (2R,3R,4S,5R)-2-(2-amino-6-chloropurin-9-yl)-5-(hydroxymethyl)-4-methoxyoxolan-3-ol

InChI: InChI=1S/C11H14ClN5O4/c1-20-7-4(2-18)21-10(6(7)19)17-3-14-5-8(12)15-11(13)16-9(5)17/h3-4,6-7,10,18-19H,2H2,1H3,(H2,13,15,16)/t4-,6-,7-,10-/m1/s1

Synonyms: 3'-O-methyl-2-amino-6-chloro-6-deamino-adenosine; (2R,3R,4S,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol

2'-O-Propargyl-5-methyl uridine

Description: It is used for the synthesis of 2'-modified nucleoside phosphoramidites and corresponding modified RNA oligomers.

CAT: BRP-00760

CAS: 860640-50-2

Molecular Formula: C13H16N2O6

Molecular Weight: 296.28

Purity: ≥97%

Appearance: White or off-white solid

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Storage: Store at 2-8 °C

Density: 1.46±0.1 g/cm3

InChIKey: BSRONJSLOYHEHY-DNRKLUKYSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)OCC#C

IUPAC Name: 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C13H16N2O6/c1-3-4-20-10-9(17)8(6-16)21-12(10)15-5-7(2)11(18)14-13(15)19/h1,5,8-10,12,16-17H,4,6H2,2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1

Synonyms: 2'-O-Propargyl-5-methyluridine; 5-Methyl-2'-O-2-propyn-1-yluridine; Uridine, 5-methyl-2'-O-2-propynyl-; Uridine, 5-methyl-2'-O-2-propyn-1-yl-; 1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-5-methyluridine

Description: It is used for the synthesis of 2'-modified nucleoside phosphoramidites and corresponding modified RNA oligomers. This modified nucleoside exhibits the exceptional ability to integrate into RNA molecules, thereby facilitating the exploration of RNA's intricate structure and functionality.

CAT: BRP-00761

CAS: 860640-56-8

Molecular Formula: C34H34N2O8

Molecular Weight: 598.64

Purity: ≥98%

Appearance: White or off-white solid

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Storage: Store at 2-8 °C

Density: 1.34±0.1 g/cm3

InChIKey: OEAZBXNAASQUGJ-PBAMLIMUSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OCC#C

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-prop-2-ynoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C34H34N2O8/c1-5-19-42-30-29(37)28(44-32(30)36-20-22(2)31(38)35-33(36)39)21-43-34(23-9-7-6-8-10-23,24-11-15-26(40-3)16-12-24)25-13-17-27(41-4)18-14-25/h1,6-18,20,28-30,32,37H,19,21H2,2-4H3,(H,35,38,39)/t28-,29-,30-,32-/m1/s1

Synonyms: 5-O-(4,4'-dimethoxytrityl)-1-deoxy-2-O-prop-2-ynyl-1-thymin-1-yl-beta-D-ribo-pentofuranose; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-2-propyn-1-yluridine; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-2-propynyl-; 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

2'-O-(2-Methoxyethyl)-5-methylcytidine hydrochloride

Description: It is used for oligonucleotide synthesis and biotechnological studies.

CAT: BRP-00767

Molecular Formula: C13H22ClN3O6

Molecular Weight: 351.78

Purity: ≥97% by HPLC

Appearance: White or off-white solid

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Storage: Store at 2-8 °C

InChIKey: YPFHLLIYUOCCOJ-YBZJUNAKSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)OCCOC.Cl

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidin-2-one;hydrochloride

InChI: InChI=1S/C13H21N3O6.ClH/c1-7-5-16(13(19)15-11(7)14)12-10(21-4-3-20-2)9(18)8(6-17)22-12;/h5,8-10,12,17-18H,3-4,6H2,1-2H3,(H2,14,15,19);1H/t8-,9-,10-,12-;/m1./s1

Synonyms: 5-Methyl-2'-methoxyethoxycytosine hydrochloride; Cytidine, 2'-O-(2-Methoxyethyl)-5-Methyl-, hydrochloride (1:1); 2'-O-MOE-5-Me-rC hydrochloride; 2'-MOE-5-Methycytidine hydrochloride; 5-Methyl-2'-O-methoxyethyl-cytidine hydrochloride

Related CAS: 244105-55-3 (free base)

5'-O-DMT-5-Hydroxyethyl-dU

Description: 5'-O-DMT-5-Hydroxyethyl-dU is a modified form of deoxyuridine (dU) featuring a 5'-O-DMT (dimethoxytrityl) protecting group and a hydroxyethyl moiety at the 5 position of the uracil base. This modification introduces hydrophilicity and alters the base pairing properties of the nucleotide, making it useful in various biochemical applications, including DNA synthesis and structural studies.

CAT: BRP-00768

CAS: 1411974-64-5

Molecular Formula: C32H34N2O8

Molecular Weight: 574.63

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Density: 1.297±0.06 g/cm3

InChIKey: KCPHUOHHZQNELQ-ZGIBFIJWSA-N

CanonicalSMILES: O=C1NC(=O)N(C=C1CCO)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(O)C2

IUPAC Name: 1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-(2-hydroxyethyl)pyrimidine-2,4(1H,3H)-dione

InChI: InChI=1S/C32H34N2O8/c1-39-25-12-8-23(9-13-25)32(22-6-4-3-5-7-22,24-10-14-26(40-2)15-11-24)41-20-28-27(36)18-29(42-28)34-19-21(16-17-35)30(37)33-31(34)38/h3-15,19,27-29,35-36H,16-18,20H2,1-2H3,(H,33,37,38)/t27-,28+,29+/m0/s1

Synonyms: 5'-O-DMT-5-Hydroxyethyl-2'-deoxyuridine; 5'-O-DMT-2'-Deoxy-5-(hydroxyethyl)uridine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-(2-hydroxyethyl)uridine

5'-O-DMT-2'-O-TBDMS-N2-ibu-L-rG

Description: 5'-O-DMT-2'-O-TBDMS-N2-ibu-L-rG is a guanosine derivative used in RNA synthesis, with a 5'-O-DMT protecting group, a TBDMS (tert-butyldimethylsilyl) group at the 2' position, and an N2-isobutyryl-L modifier at the guanine base. This modification enhances stability and controlled reactivity during oligonucleotide assembly, making it suitable for RNA research and therapeutic development.

CAT: BRP-00769

CAS: 679809-77-9

Molecular Formula: C41H51N5O8Si

Molecular Weight: 769.97

Purity: ≥97% by HPLC

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Density: 1.25±0.1 g/cm3

InChIKey: JMCNKJFOIJGYRG-XECBKSLKSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[9-[(2S,3S,4S,5S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C41H51N5O8Si/c1-25(2)36(48)44-39-43-35-32(37(49)45-39)42-24-46(35)38-34(54-55(8,9)40(3,4)5)33(47)31(53-38)23-52-41(26-13-11-10-12-14-26,27-15-19-29(50-6)20-16-27)28-17-21-30(51-7)22-18-28/h10-22,24-25,31,33-34,38,47H,23H2,1-9H3,(H2,43,44,45,48,49)/t31-,33-,34-,38-/m0/s1

Synonyms: 5'-O-DMT-2'-O-(tertbutyldimethylsilyl)-N2-isobutyryl-L-Guanosine; N-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-L-ribofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methylpropanamide

N6-Benzoyl-2',3'-di-O-acetyladenosine

Description: N6-Benzoyl-2’,3’-di-O-acetyladenosine is a modified form of adenosine featuring a benzoyl group at the N6 position and di-O-acetyl groups at the 2' and 3' positions of the ribose sugar. These modifications provide stability and alter the chemical properties of adenosine, making it useful in various biochemical applications, including RNA synthesis and modification studies.

CAT: BRP-00770

CAS: 69293-36-3

Molecular Formula: C21H21N5O7

Molecular Weight: 455.43

Purity: ≥95%

Appearance: White to off-white powder

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Storage: Store at 2-8 °C

Density: 1.55±0.1 g/cm3

InChIKey: FGYJKVXTRQIWTE-VGKBRBPRSA-N

CanonicalSMILES: CC(=O)OC1C(OC(C1OC(=O)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO

IUPAC Name: [(2R,3R,4R,5R)-4-acetyloxy-5-(6-benzamidopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] acetate

InChI: InChI=1S/C21H21N5O7/c1-11(28)31-16-14(8-27)33-21(17(16)32-12(2)29)26-10-24-15-18(22-9-23-19(15)26)25-20(30)13-6-4-3-5-7-13/h3-7,9-10,14,16-17,21,27H,8H2,1-2H3,(H,22,23,25,30)/t14-,16-,17-,21-/m1/s1

Synonyms: Adenosine, N-benzoyl-, 2',3'-diacetate; 2',3'-di-O-Acetyl-N6-Benzoyl-Adenosine; N6-Bz-2',3'-Acetyl-Adenosine; N6-benzoyl-2',3'-Acetyl-Adenosine; (2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diyl diacetate; 2',3'-diAc-A(Bz); N6-benzoyl-2',3'-diacetyl-adenosine

(E)-N'-(1-Benzyl-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

Description: (E)-N'-(1-Benzyl-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide is a chemical compound used in organic synthesis and medicinal chemistry. It is often utilized as a precursor or intermediate in the synthesis of nucleoside analogs or other bioactive compounds.

CAT: BRP-00795

Molecular Formula: C20H24N6O5

Molecular Weight: 428.44

Purity: 98%

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InChIKey: ALGXQQKQSPSJBB-DJWODFLFSA-N

InChI: InChI=1S/C20H24N6O5/c1-24(2)10-22-20-23-17-14(18(30)25(20)8-12-6-4-3-5-7-12)21-11-26(17)19-16(29)15(28)13(9-27)31-19/h3-7,10-11,13,15-16,19,27-29H,8-9H2,1-2H3/b22-10+/t13-,15-,16-,19-/m1/s1

5,8-Dihydro-N,N,5-trimethyl-8-β-D-ribofuranosylpyrrolo[2',3':4,5]pyrrolo[2,3-d]pyrimidin-4-amine

Description: 5,8-Dihydro-N,N,5-trimethyl-8-β-D-ribofuranosylpyrrolo[2',3':4,5]pyrrolo[2,3-d]pyrimidin-4-amine is a chemical compound with potential biological activity. It is often studied for its potential pharmacological properties or as a building block in medicinal chemistry for the synthesis of nucleoside analogs.

CAT: BRP-00796

CAS: 2180983-51-9

Molecular Formula: C16H21N5O4

Molecular Weight: 347.37

Purity: 98%

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Density: 1.62±0.1 g/cm3

Boiling Point: 588.6±50.0 °C at 760 mmHg

InChIKey: GIPKNLNHAZHJMS-RVXWVPLUSA-N

CanonicalSMILES: CN1C=CC2=C1C3=C(N2C4C(C(C(O4)CO)O)O)N=CN=C3N(C)C

IUPAC Name: (2R,3R,4S,5R)-2-[12-(dimethylamino)-3-methyl-3,7,9,11-tetrazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),4,9,11-pentaen-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol

InChI: InChI=1S/C16H21N5O4/c1-19(2)14-10-11-8(4-5-20(11)3)21(15(10)18-7-17-14)16-13(24)12(23)9(6-22)25-16/h4-5,7,9,12-13,16,22-24H,6H2,1-3H3/t9-,12-,13-,16-/m1/s1

Synonyms: Pyrrolo[2',3':4,5]pyrrolo[2,3-d]pyrimidin-4-amine, 5,8-dihydro-N,N,5-trimethyl-8-β-D-ribofuranosyl-; (2R,3R,4S,5R)-2-(4-(Dimethylamino)-5-methylpyrrolo[2',3':4,5]pyrrolo[2,3-d]pyrimidin-8(5H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

5-O-DMT-N2-Dimethylformamide-2-O-methylguanosine

Description: 5-O-DMT-N2-Dimethylformamide-2-O-methylguanosine is a modified nucleoside compound commonly used in RNA synthesis and modification studies. It is often employed as a building block for the synthesis of RNA molecules with specific modifications for various biological and research purposes.

CAT: BRP-00797

CAS: 1858223-91-2

Molecular Formula: C35H38N6O7

Molecular Weight: 654.71

Purity: 97%

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.33±0.1 g/cm3

Boiling Point: 848.7±75.0 °C at 760 mmHg

InChIKey: SBJHBQZDABMKCF-JHZZHVAFSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)OC

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C35H38N6O7/c1-40(2)20-37-34-38-31-28(32(43)39-34)36-21-41(31)33-30(46-5)29(42)27(48-33)19-47-35(22-9-7-6-8-10-22,23-11-15-25(44-3)16-12-23)24-13-17-26(45-4)18-14-24/h6-18,20-21,27,29-30,33,42H,19H2,1-5H3,(H,38,39,43)/t27-,29-,30-,33-/m1/s1

Synonyms: N'-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide; 5'-O-DMT-N2-DMF-2'-O-methylguanosine; N2-dmf-DMT-2'-OMe-Gr; N2-dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-Guanosine

(E)-N2-Dimethylformamide-2-O-methylguanosine

Description: (E)-N2-Dimethylformamide-2-O-methylguanosine is a modified nucleoside compound used in RNA synthesis and modification studies. It is commonly employed as a building block for the synthesis of RNA molecules with specific modifications, allowing researchers to investigate RNA structure, function, and interactions.

CAT: BRP-00798

CAS: 1951424-87-5

Molecular Formula: C14H20N6O5

Molecular Weight: 352.35

Purity: 98%

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Density: 1.63±0.1 g/cm3

Boiling Point: 672.2±65.0 °C at 760 mmHg

InChIKey: KDQQTCFKBCWYFL-GTACIXLRSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)OC

IUPAC Name: (E)-N'-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C14H20N6O5/c1-19(2)5-16-14-17-11-8(12(23)18-14)15-6-20(11)13-10(24-3)9(22)7(4-21)25-13/h5-7,9-10,13,21-22H,4H2,1-3H3,(H,17,18,23)/b16-5+/t7-,9-,10-,13-/m1/s1

Synonyms: (E)-N-[(Dimethylamino)methylene]-2'-O-methylguanosine; (E)-N'-(9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

Related CAS: 183737-04-4 (N-[(Dimethylamino)methylene]-2'-O-methylguanosine)

[N(E)]-N-[(Dimethylamino)methylene]guanosine

Description: [N(E)]-N-[(Dimethylamino)methylene]guanosine is a modified nucleoside compound commonly utilized in biochemical research, particularly in RNA studies. This modification is often used to investigate RNA structure, function, and interactions, providing valuable insights into biological processes such as RNA folding, RNA-protein interactions, and RNA catalysis.

CAT: BRP-00799

CAS: 1055407-32-3

Molecular Formula: C13H18N6O5

Molecular Weight: 338.32

Purity: 98%

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Density: 1.77±0.1 g/cm3

Boiling Point: 708.5±70.0 °C at 760 mmHg

InChIKey: WDAVDBAMSKZBEN-PZYHSTABSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)O

IUPAC Name: (E)-N'-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C13H18N6O5/c1-18(2)4-15-13-16-10-7(11(23)17-13)14-5-19(10)12-9(22)8(21)6(3-20)24-12/h4-6,8-9,12,20-22H,3H2,1-2H3,(H,16,17,23)/b15-4+/t6-,8-,9-,12-/m1/s1

Synonyms: (E)-N'-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-3H-purin-2-yl)-N,N-dimethylformimidamide; Guanosine, N-[(dimethylamino)methylene]-, [N(E)]-; (E)-N2-DMF-rG; N-dimethylaminomethylene guanosine

Related CAS: 17331-16-7 (N-[(Dimethylamino)methylene]guanosine)

2'-O-TBDMS-N2-DMF-rG

Description: 2'-O-TBDMS-N2-DMF-rG is a modified nucleoside commonly employed in RNA synthesis and modification studies. It contains a guanosine base with modifications at the 2'-position (TBDMS) and N2 position (DMF). The TBDMS group protects the 2'-hydroxyl group, while the DMF group is attached to the N2 position. This modification allows researchers to introduce specific functionalities into RNA molecules for various research purposes, such as structural studies, RNA-protein interactions, or RNA labeling experiments, providing valuable insights into RNA biology and function.

CAT: BRP-00800

CAS: 126922-63-2

Molecular Formula: C19H32N6O5Si

Molecular Weight: 452.58

Purity: 98%

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Density: 1.34±0.1 g/cm3

InChIKey: ILIKLOCTYDXXNJ-LSCFUAHRSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C2N=C(NC3=O)N=CN(C)C)CO)O

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C19H32N6O5Si/c1-19(2,3)31(6,7)30-14-13(27)11(8-26)29-17(14)25-10-20-12-15(25)22-18(23-16(12)28)21-9-24(4)5/h9-11,13-14,17,26-27H,8H2,1-7H3,(H,22,23,28)/t11-,13-,14-,17-/m1/s1

Synonyms: Guanosine, N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; N-[(Dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]guanosine; N'-(9-((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

5-Bromotubercidin

Description: 5-Bromotubercidin is a chemical compound commonly utilized in biochemical research and drug development. It belongs to the class of tubercidin analogs and is known for its inhibitory effects on various enzymes, including kinases.

CAT: BRP-00801

CAS: 21193-80-6

Molecular Formula: C11H13BrN4O4

Molecular Weight: 345.15

Purity: 97%

Appearance: White to off-white solid

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Storage: Store at 2-8 °C, protect from light

Density: 2.26±0.1 g/cm3

Melting Point: 232 °C

Boiling Point: 686.9±55.0 °C at 760 mmHg

InChIKey: ZWTPRQXZXQEKFT-IOSLPCCCSA-N

Solubility: Soluble in DMSO (Slightly), Methanol (Slightly)

CanonicalSMILES: C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)Br

IUPAC Name: (2R,3R,4S,5R)-2-(4-amino-5-bromopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol

InChI: InChI=1S/C11H13BrN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1

Synonyms: (2R,3R,4S,5R)-2-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; Bromotubercidin; 5-Bromo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; NSC103802

O2',O3',O5'-Tribenzoyl-5-methyl-2-thiouridine

Description: O2',O3',O5'-Tribenzoyl-5-methyl-2-thiouridine is a modified nucleoside compound often used in RNA research and modification studies. It contains a uridine base with modifications at the 2nd position (thio), and the 2', 3', and 5' hydroxyl groups are tribenzoylated. This modification is utilized to study RNA structure, function, and interactions, providing insights into RNA biology and potential therapeutic applications.

CAT: BRP-00802

CAS: 75921-08-3

Molecular Formula: C31H26N2O8S

Molecular Weight: 586.61

Purity: 98%

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Density: 1.43±0.1 g/cm3

InChIKey: JEAZFXFXZLAZLW-DLGLWYJGSA-N

CanonicalSMILES: CC1=CN(C(=S)NC1=O)C2C(C(C(O2)COC(=O)C3=CC=CC=C3)OC(=O)C4=CC=CC=C4)OC(=O)C5=CC=CC=C5

IUPAC Name: [(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-(5-methyl-4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methyl benzoate

InChI: InChI=1S/C31H26N2O8S/c1-19-17-33(31(42)32-26(19)34)27-25(41-30(37)22-15-9-4-10-16-22)24(40-29(36)21-13-7-3-8-14-21)23(39-27)18-38-28(35)20-11-5-2-6-12-20/h2-17,23-25,27H,18H2,1H3,(H,32,34,42)/t23-,24-,25-,27-/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((Benzoyloxy)methyl)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl dibenzoate; Uridine, 5-methyl-2-thio-, 2',3',5'-tribenzoate

2',3'-O-Isopropylidenecytidine sulfate

Description: 2',3'-O-Isopropylidenecytidine sulfate is a modified nucleoside compound frequently employed in RNA synthesis and modification studies. It contains a cytidine base with protection at the 2' and 3' hydroxyl groups by isopropylidene and is in the form of a sulfate salt.

CAT: BRP-00803

CAS: 1955522-00-5

Molecular Formula: C12H19N3O9S

Molecular Weight: 381.36

Purity: 98%

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InChIKey: WEIXBFRDOMNWIS-RQDZQORCSA-N

CanonicalSMILES: CC1(OC2C(OC(C2O1)N3C=CC(=NC3=O)N)CO)C.OS(=O)(=O)O

IUPAC Name: 1-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-4-aminopyrimidin-2-one;sulfuric acid

InChI: InChI=1S/C12H17N3O5.H2O4S/c1-12(2)19-8-6(5-16)18-10(9(8)20-12)15-4-3-7(13)14-11(15)17;1-5(2,3)4/h3-4,6,8-10,16H,5H2,1-2H3,(H2,13,14,17);(H2,1,2,3,4)/t6-,8-,9-,10-;/m1./s1

Synonyms: 4-Amino-1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidin-2(1H)-one sulfate; 2',3'-Isopropylidenecytidine sulfate; 2',3'-O-(1-Methylethylidene)cytidine sulfate

Related CAS: 362-42-5 (free base)

1-(β-D-lyxofuranosyl)uracil

Description: 1-(β-D-lyxofuranosyl)uracil is a nucleoside compound commonly used in nucleic acid research and drug development. This modified nucleoside is employed in the study of nucleic acid structure and function, and can be used as an analog in the synthesis of oligonucleotides. Additionally, it has potential applications in the development of antiviral and anticancer therapeutics by mimicking natural nucleosides and interfering with nucleic acid metabolism.

CAT: BRP-00804

CAS: 4348-61-2

Molecular Formula: C9H12N2O6

Molecular Weight: 244.20

Purity: 98%

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Density: 1.674±0.06 g/cm3 (Predicted)

Melting Point: 203-204 °C

InChIKey: DRTQHJPVMGBUCF-YDKYIBAVSA-N

CanonicalSMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O

IUPAC Name: 1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6+,7+,8-/m1/s1

Synonyms: 1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-β-D-lyxofuranosyl-uracil; 2,4(1H,3H)-Pyrimidinedione, 1-β-D-lyxofuranosyl-