What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - RNA / BOC Sciences

(E)-Ethyl 3-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylate

Description: (E)-Ethyl 3-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylate is a modified nucleoside derivative used in biochemical and pharmaceutical research. The modifications enhance its utility in studying nucleic acid interactions and functions, and it can serve as an intermediate in the synthesis of nucleoside analogs. These analogs have potential therapeutic applications, particularly in antiviral and anticancer treatments, by interfering with nucleic acid metabolism and replication processes.

CAT: BRP-00805

CAS: 123881-85-6

Molecular Formula: C14H18N2O8

Molecular Weight: 342.30

Purity: 98%

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Storage: Store at 2-8 °C

Density: 1.583±0.06 g/cm3

InChIKey: ATSFSUUXRHMGQU-BGFIHSBQSA-N

CanonicalSMILES: CCOC(=O)C=CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O

IUPAC Name: ethyl (E)-3-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enoate

InChI: InChI=1S/C14H18N2O8/c1-2-23-9(18)4-3-7-5-16(14(22)15-12(7)21)13-11(20)10(19)8(6-17)24-13/h3-5,8,10-11,13,17,19-20H,2,6H2,1H3,(H,15,21,22)/b4-3+/t8-,10-,11-,13-/m1/s1

Synonyms: 2-Propenoic acid, 3-[1,2,3,4-tetrahydro-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidinyl]-, ethyl ester, (E)-

6-Fluoro-3,4-dihydro-3-oxo-4-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazinecarboxamide

Description: 6-Fluoro-3,4-dihydro-3-oxo-4-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazinecarboxamide is a modified nucleoside analog used in biochemical research and pharmaceutical development. The modifications enhance its stability and facilitate its incorporation into nucleic acids. It is often utilized in the synthesis of nucleoside analogs for studying nucleic acid interactions, function, and potential therapeutic applications, particularly in the development of antiviral and anticancer agents.

CAT: BRP-00807

CAS: 499785-96-5

Molecular Formula: C16H18FN3O9

Molecular Weight: 415.33

Purity: 98%

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Density: 1.61±0.1 g/cm3

Boiling Point: 524.4±60.0 °C at 760 mmHg

InChIKey: IVDSFFUXGZDUGN-RVXWVPLUSA-N

CanonicalSMILES: CC(=O)OCC1C(C(C(O1)N2C=C(N=C(C2=O)C(=O)N)F)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(3-carbamoyl-5-fluoro-2-oxopyrazin-1-yl)oxolan-2-yl]methyl acetate

InChI: InChI=1S/C16H18FN3O9/c1-6(21)26-5-9-12(27-7(2)22)13(28-8(3)23)16(29-9)20-4-10(17)19-11(14(18)24)15(20)25/h4,9,12-13,16H,5H2,1-3H3,(H2,18,24)/t9-,12-,13-,16-/m1/s1

Synonyms: Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-4-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-; Acetic acid (2R,3R,4R,5R)-3,4-diacetoxy-5-(3-carbamoyl-5-fluoro-2-oxo-2H-pyrazin-1-yl)-tetrahydro-furan-2-ylmethyl ester; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(3-carbamoyl-5-fluoro-2-oxopyrazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

2-O-Ethyl-2'-O-methyluridine

Description: 2-O-Ethyl-2'-O-methyluridine is a modified nucleoside used in biochemical research, particularly in the study of RNA synthesis and modification. These modifications increase the stability and resistance to enzymatic degradation of the nucleoside, making it useful in the development of therapeutic oligonucleotides and the study of RNA structure and function.

CAT: BRP-00808

CAS: 1352173-49-9

Molecular Formula: C12H18N2O6

Molecular Weight: 286.28

Purity: 98%

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Density: 1.47±0.1 g/cm3

Boiling Point: 466.2±55.0 °C at 760 mmHg

InChIKey: NZNRDRCBHUXJKX-QCNRFFRDSA-N

CanonicalSMILES: CCOC1=NC(=O)C=CN1C2C(C(C(O2)CO)O)OC

IUPAC Name: 2-ethoxy-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-4-one

InChI: InChI=1S/C12H18N2O6/c1-3-19-12-13-8(16)4-5-14(12)11-10(18-2)9(17)7(6-15)20-11/h4-5,7,9-11,15,17H,3,6H2,1-2H3/t7-,9-,10-,11-/m1/s1

Synonyms: 2'-O-Methyl-2-O-ethyluridine; 2-Ethoxy-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-4(1H)-one

S-(5')-Adenosyl-3-thiopropylamine

Description: S-(5')-Adenosyl-3-thiopropylamine is a modified nucleoside compound used in biochemical research, particularly in the study of enzyme mechanisms and metabolic pathways. This compound consists of an adenosine moiety linked to a 3-thiopropylamine group via a sulfur atom at the 5' position. It serves as a cofactor or substrate analog in various enzymatic reactions, providing insights into the role of sulfur-containing nucleosides in biological processes and potential therapeutic applications.

CAT: BRP-00810

CAS: 53186-57-5

Molecular Formula: C13H20N6O3S

Molecular Weight: 340.40

Purity: 98%

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Density: 1.78±0.1 g/cm3

Boiling Point: 683.7±65.0 °C at 760 mmHg

InChIKey: FUSRAALGPJJIRO-QYVSTXNMSA-N

CanonicalSMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CSCCCN)O)O)N

IUPAC Name: (2S,3S,4R,5R)-2-(3-aminopropylsulfanylmethyl)-5-(6-aminopurin-9-yl)oxolane-3,4-diol

InChI: InChI=1S/C13H20N6O3S/c14-2-1-3-23-4-7-9(20)10(21)13(22-7)19-6-18-8-11(15)16-5-17-12(8)19/h5-7,9-10,13,20-21H,1-4,14H2,(H2,15,16,17)/t7-,9-,10-,13-/m1/s1

Synonyms: S-Adenosyl-3-thiopropylamine; 5'-S-(3-Aminopropyl)-5'-thioadenosine; 5''-(Aminopropylthio)-5''-deoxy-adenosine; (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-((3-aminopropylthio)methyl)tetrahydrofuran-3,4-diol

Related CAS: 99019-00-8 (sulfate)

N4-Ac-2'-O-4'-C-Locked-Cr

Description: N4-Ac-2'-O-4'-C-Locked-Cr is a modified nucleoside used in oligonucleotide synthesis. It consists of an acetyl group (Ac) at the N4 position of the cytosine, a 2'-O modification, and a 4'-carbon locked cytosine (Locked-Cr). This modification is designed to stabilize the oligonucleotide structure and alter its properties for specific applications in nucleic acid research and biotechnology.

CAT: BRP-00986

CAS: 391199-75-0

Molecular Formula: C12H15N3O6

Molecular Weight: 297.27

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Density: 1.77±0.1 g/cm3

Melting Point: 223-225 °C (dec.)

InChIKey: DLDUBZSJKKUTMP-KLBPJQLPSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C3C(C(O2)(CO3)CO)O

IUPAC Name: N-[1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C12H15N3O6/c1-6(17)13-7-2-3-15(11(19)14-7)10-8-9(18)12(4-16,21-10)5-20-8/h2-3,8-10,16,18H,4-5H2,1H3,(H,13,14,17,19)/t8-,9+,10-,12+/m1/s1

Synonyms: N4-acetyl-2'-O-4'-C-Locked-cytidine; Acetamide, N-[1-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]-; LNA C(Ac)

N4-Dibutylformamidine-2'-O-Me-Cr

Description: N4-Dibutylformamidine-2'-O-Me-Cr is a modified nucleoside used in oligonucleotide synthesis. It consists of a dibutylformamidine group attached to the N4 position of cytosine, a methyl (Me) group at the 2' position of ribose, and a modified cytosine (Cr). This modification alters the properties of the oligonucleotide and can be utilized for specific applications in nucleic acid research and biotechnology.

CAT: BRP-00987

Molecular Formula: C19H32N4O5

Molecular Weight: 396.49

Purity: ≥98% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: MMQXUCDIZCUQOH-VDHUWJSZSA-N

IUPAC Name: N,N-dibutyl-N'-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)formimidamide

InChI: InChI=1S/C19H32N4O5/c1-4-6-9-22(10-7-5-2)13-20-15-8-11-23(19(26)21-15)18-17(27-3)16(25)14(12-24)28-18/h8,11,13-14,16-18,24-25H,4-7,9-10,12H2,1-3H3/t14-,16-,17-,18-/m1/s1

Synonyms: N4-dibutylformamidine-2'-O-methyl-cytidine

N1-Methylene pivalate-N2-dibutylformamidine-2'-O-Me-Gr

Description: N1-Methylene pivalate-N2-dibutylformamidine-2'-O-Me-Gr is a modified nucleoside used in oligonucleotide synthesis. It consists of a methylene pivalate group attached to the N1 position of guanine, a dibutylformamidine group attached to the N2 position of guanine, a methyl (Me) group at the 2' position of ribose, and a modified guanine (Gr). This modification alters the properties of the oligonucleotide and can be employed for specific applications in nucleic acid research and biotechnology.

CAT: BRP-00988

Molecular Formula: C26H42N6O7

Molecular Weight: 550.66

Purity: ≥98% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: FJYUEQOQXMHZLF-ZDXOVATRSA-N

IUPAC Name: (2-(((dibutylamino)methylene)amino)-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-1-yl)methyl pivalate

InChI: InChI=1S/C26H42N6O7/c1-7-9-11-30(12-10-8-2)14-28-25-29-21-18(22(35)32(25)16-38-24(36)26(3,4)5)27-15-31(21)23-20(37-6)19(34)17(13-33)39-23/h14-15,17,19-20,23,33-34H,7-13,16H2,1-6H3/t17-,19-,20-,23-/m1/s1

Synonyms: N1-methylene pivalate-N2-dibutylformamidine-2'-O-methyl-guanosine

N2-Dibutylformamidine-2'-O-Me-Gr

Description: N2-Dibutylformamidine-2'-O-Me-Gr is a modified nucleoside used in oligonucleotide synthesis. It consists of a dibutylformamidine group attached to the N2 position of guanine, a methyl (Me) group at the 2' position of ribose, and a modified guanine (Gr). This modification can alter the properties of the oligonucleotide for specific applications in nucleic acid research and biotechnology.

CAT: BRP-00989

Molecular Formula: C20H32N6O5

Molecular Weight: 436.51

Purity: ≥98% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: KZJIRTOCSLCQKS-NVQRDWNXSA-N

IUPAC Name: N,N-dibutyl-N'-(9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)formimidamide

InChI: InChI=1S/C20H32N6O5/c1-4-6-8-25(9-7-5-2)11-22-20-23-17-14(18(29)24-20)21-12-26(17)19-16(30-3)15(28)13(10-27)31-19/h11-13,15-16,19,27-28H,4-10H2,1-3H3,(H,23,24,29)/t13-,15-,16-,19-/m1/s1

Synonyms: N2-dibutylformamidine-2'-O-methyl-guanosine

8-Br-N2-iBu-2'-OMe-Gr

Description: 8-Br-N2-iBu-2'-OMe-Gr is a modified nucleoside used in oligonucleotide synthesis. It consists of a bromine (Br) atom at the 8th position of guanine, an isobutyl (iBu) group attached to the N2 position of guanine, a methyl (Me) group at the 2' position of ribose, and a modified guanine (Gr). This modification can introduce specific properties or functionalities to the oligonucleotide for various applications in nucleic acid research and biotechnology.

CAT: BRP-00990

CAS: 2920231-98-5

Molecular Formula: C15H20BrN5O6

Molecular Weight: 446.25

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Density: 1.93±0.1 g/cm3

InChIKey: VMDRFWCYFGNAGO-HTVVRFAVSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=C(N2C3C(C(C(O3)CO)O)OC)Br

IUPAC Name: N-[8-bromo-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C15H20BrN5O6/c1-5(2)11(24)19-15-18-10-7(12(25)20-15)17-14(16)21(10)13-9(26-3)8(23)6(4-22)27-13/h5-6,8-9,13,22-23H,4H2,1-3H3,(H2,18,19,20,24,25)/t6-,8-,9-,13-/m1/s1

Synonyms: 8-bromo-N2-isobutyryl-2'-O-methyl-guanosine; N2-Isobutyryl-8-bromo-2'-O-methyl-guanosine; N-(8-bromo-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; N2-iBu-8-Br-2'-O-Me-G

N4-Ac-5-I-2'-O-Me-Cr

Description: N4-Ac-5-I-2'-O-Me-Cr is a modified nucleoside used in oligonucleotide synthesis. It consists of an acetyl group (Ac) at the N4 position of cytosine, an iodine atom (I) at the 5th position of cytosine, a methyl (Me) group at the 2' position of ribose, and a modified cytosine (Cr). This modification can impart specific properties or functionalities to the oligonucleotide for various applications in nucleic acid research and biotechnology.

CAT: BRP-00991

CAS: 1402062-84-3

Molecular Formula: C12H16IN3O6

Molecular Weight: 425.18

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Density: 2.05±0.1 g/cm3

InChIKey: UKLQCCOIWJBTQA-TURQNECASA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1I)C2C(C(C(O2)CO)O)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-5-iodo-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C12H16IN3O6/c1-5(18)14-10-6(13)3-16(12(20)15-10)11-9(21-2)8(19)7(4-17)22-11/h3,7-9,11,17,19H,4H2,1-2H3,(H,14,15,18,20)/t7-,8-,9-,11-/m1/s1

Synonyms: N4-Acetyl-5-iodo-2'-O-methyl-cytidine; N-Acetyl-5-iodo-2'-O-methylcytidine; N-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-5-iodo-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

DiPac-2,6-diamino-2'-OMe-purine-ribose

Description: DiPac-2,6-diamino-2'-OMe-purine-ribose is a modified nucleoside used in oligonucleotide synthesis. This modification consists of a DiPac (diphenoxyacetyl) group attached to the 2-amino and 6-amino positions of purine, and a methyl (Me) group at the 2' position of ribose. It is utilized in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence.

CAT: BRP-00992

Molecular Formula: C27H30N6O8

Molecular Weight: 566.56

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InChIKey: PVYFBCVGORXSLW-CCCLMZFYSA-N

IUPAC Name: N,N'-(9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-6,9-dihydro-1H-purine-2,6-diyl)bis(2-phenoxyacetamide)

InChI: InChI=1S/C27H30N6O8/c1-38-23-22(37)18(12-34)41-26(23)33-15-28-21-24(29-19(35)13-39-16-8-4-2-5-9-16)31-27(32-25(21)33)30-20(36)14-40-17-10-6-3-7-11-17/h2-11,15,18,22-24,26,34,37H,12-14H2,1H3,(H,29,35)(H2,30,31,32,36)/t18-,22-,23-,24?,26-/m1/s1

Synonyms: DiPac-2,6-diamino-2'-O-methyl-purine-ribose; N2-amino-Pac-2'-O-Me-A(N6-Pac)

N6-iBu-2'-OMe-Ar

Description: N6-iBu-2'-OMe-Ar includes an isobutyl (iBu) group attached to the N6 position of adenine, a methyl (Me) group at the 2' position of ribose, and an aromatic group (Ar). It is utilized in oligonucleotide synthesis and can introduce specific functionalities to the oligonucleotide.

CAT: BRP-00993

CAS: 1084891-36-0

Molecular Formula: C15H21N5O5

Molecular Weight: 351.36

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Density: 1.59±0.1 g/cm3

InChIKey: IRXHRDQDJTWQAV-ORXWAGORSA-N

CanonicalSMILES: CC(C)C(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]purin-6-yl]-2-methylpropanamide

InChI: InChI=1S/C15H21N5O5/c1-7(2)14(23)19-12-9-13(17-5-16-12)20(6-18-9)15-11(24-3)10(22)8(4-21)25-15/h5-8,10-11,15,21-22H,4H2,1-3H3,(H,16,17,19,23)/t8-,10-,11-,15-/m1/s1

Synonyms: N6-isobutyryl-2'-O-methyl-adenosine; N-(9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)isobutyramide; 2'-O-Methyl-N-(2-methyl-1-oxopropyl)adenosine

N4-Ac-2'-O-Me-5-Me-Cr

Description: N4-Ac-2'-O-Me-5-Me-Cr comprises an acetyl group (Ac) attached to the N4 position of cytosine, a methyl (Me) group at the 2' position of ribose, and a methyl group (Me) at the 5th position of cytosine. It is used in oligonucleotide synthesis and can alter the properties of the resulting oligonucleotide.

CAT: BRP-00994

CAS: 741725-58-6

Molecular Formula: C13H19N3O6

Molecular Weight: 313.31

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Density: 1.53±0.1 g/cm3

InChIKey: DGSGYQXEJYKLEH-DNRKLUKYSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C(C(C(O2)CO)O)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C13H19N3O6/c1-6-4-16(13(20)15-11(6)14-7(2)18)12-10(21-3)9(19)8(5-17)22-12/h4,8-10,12,17,19H,5H2,1-3H3,(H,14,15,18,20)/t8-,9-,10-,12-/m1/s1

Synonyms: N4-acetyl-2'-O-methyl-5-methyl-cytidine; N4-Acetyl-5-methyl-2'-O-methyl-cytidine; Cytidine, N-acetyl-5-methyl-2'-O-methyl-

N4-dmf-2'-O-Me-5-Me-Cr

Description: N4-dmf-2'-O-Me-5-Me-Cr contains a dibutylformamidine (dmf) group attached to the N4 position of cytosine, a methyl (Me) group at the 2' position of ribose, and a methyl group (Me) at the 5th position of cytosine. It is utilized in oligonucleotide synthesis and can introduce specific functionalities to the oligonucleotide.

CAT: BRP-00995

Molecular Formula: C14H22N4O5

Molecular Weight: 326.35

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InChIKey: DICOFXKPAKWPIN-PRULPYPASA-N

CanonicalSMILES: O=C1N=C(N=CN(C)C)C(=CN1C2OC(CO)C(O)C2OC)C

IUPAC Name: N'-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)-N,N-dimethylformimidamide

InChI: InChI=1S/C14H22N4O5/c1-8-5-18(14(21)16-12(8)15-7-17(2)3)13-11(22-4)10(20)9(6-19)23-13/h5,7,9-11,13,19-20H,6H2,1-4H3/t9-,10-,11-,13-/m1/s1

Synonyms: N4-dimethylformamidine-2'-O-methyl-5-methyl-cytidine

Related CAS: 2920179-30-0 (Z-isomer)

N3-BOM-3'-O-Bz-2'-O-Me-U

Description: N3-BOM-3'-O-Bz-2'-O-Me-U is a modified nucleoside used in oligonucleotide synthesis. This modification consists of a benzyl oxy methyl (BOM) group attached to the N3 position of uracil, a benzoyl (Bz) group at the 3' position of ribose, and a methyl (Me) group at the 2' position of ribose. It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence.

CAT: BRP-00996

CAS: 2197181-75-0

Molecular Formula: C25H26N2O8

Molecular Weight: 482.49

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.39±0.1 g/cm3

Boiling Point: 632.2±65.0 °C at 760 mmHg

InChIKey: DJMBMKCDFWFZOO-JMJGKCIBSA-N

CanonicalSMILES: COC1C(C(OC1N2C=CC(=O)N(C2=O)COCC3=CC=CC=C3)CO)OC(=O)C4=CC=CC=C4

IUPAC Name: [(2R,3R,4R,5R)-5-[2,4-dioxo-3-(phenylmethoxymethyl)pyrimidin-1-yl]-2-(hydroxymethyl)-4-methoxyoxolan-3-yl] benzoate

InChI: InChI=1S/C25H26N2O8/c1-32-22-21(35-24(30)18-10-6-3-7-11-18)19(14-28)34-23(22)26-13-12-20(29)27(25(26)31)16-33-15-17-8-4-2-5-9-17/h2-13,19,21-23,28H,14-16H2,1H3/t19-,21-,22-,23-/m1/s1

Synonyms: N3-Benzyloxymethyl-3'-O-Benzoyl-2'-O-Methyl-uridine

N6-Bz-DMT-2'-O-4'-C-Locked-Ar

Description: N6-Bz-DMT-2'-O-4'-C-Locked-Ar is a modified nucleoside used in oligonucleotide synthesis. This modification consists of a benzoyl (Bz) group attached to the N6 position of adenine, a dimethoxytrityl (DMT) protecting group, a 2'-O modification, and a 4'-carbon locked adenine (Locked-Ar). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-00997

CAS: 206055-74-5

Molecular Formula: C39H35N5O7

Molecular Weight: 685.72

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.38±0.1 g/cm3

InChIKey: QKRIAIFSTHOZRG-WBZZMTOKSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC45COC(C4O)C(O5)N6C=NC7=C(N=CN=C76)NC(=O)C8=CC=CC=C8

IUPAC Name: N-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]purin-6-yl]benzamide

InChI: InChI=1S/C39H35N5O7/c1-47-29-17-13-27(14-18-29)39(26-11-7-4-8-12-26,28-15-19-30(48-2)20-16-28)50-22-38-21-49-32(33(38)45)37(51-38)44-24-42-31-34(40-23-41-35(31)44)43-36(46)25-9-5-3-6-10-25/h3-20,23-24,32-33,37,45H,21-22H2,1-2H3,(H,40,41,43,46)/t32-,33+,37-,38-/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-adenosine; N-(9-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-9H-purin-6-yl)benzamide; N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-α-L-lyxofuranosyl]-9H-purin-6-yl]benzamide; 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-O,4'-C-methyleneadenosine; 5'-DMTr-LNA-N6-Bz-A

N4-Ac-DMT-2'-O-4'-C-Locked-Cr

Description: N4-Ac-DMT-2'-O-4'-C-Locked-Cr is a modified nucleoside used in oligonucleotide synthesis. This modification consists of an acetyl (Ac) group attached to the N4 position of cytosine, a dimethoxytrityl (DMT) protecting group, a 2'-O modification, and a 4'-carbon locked cytosine (Locked-Cr). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-00998

CAS: 1092705-83-3

Molecular Formula: C33H33N3O8

Molecular Weight: 599.64

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Density: 1.34±0.1 g/cm3

InChIKey: MQRGVNKBORBIIG-FHRWSLRQSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC3(COC2C3O)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)NC(=O)C

IUPAC Name: N-(1-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C33H33N3O8/c1-21(37)34-27-17-18-36(31(39)35-27)30-28-29(38)32(44-30,19-42-28)20-43-33(22-7-5-4-6-8-22,23-9-13-25(40-2)14-10-23)24-11-15-26(41-3)16-12-24/h4-18,28-30,38H,19-20H2,1-3H3,(H,34,35,37,39)/t28-,29+,30-,32-/m1/s1

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O,4'-C-methylenecytidine

N2-dmf-DMT-2'-O-4'-C-Locked-Gr

Description: N2-dmf-DMT-2'-O-4'-C-Locked-Gr is a modified nucleoside used in oligonucleotide synthesis. This modification consists of a dibutylformamidine (dmf) group attached to the N2 position of guanine, a dimethoxytrityl (DMT) protecting group, a 2'-O modification, and a 4'-carbon locked guanine (Locked-Gr). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-00999

CAS: 709641-78-1

Molecular Formula: C35H36N6O7

Molecular Weight: 652.70

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.38±0.1 g/cm3

Boiling Point: 858.1±75.0 °C at 760 mmHg

InChIKey: GHGCTOJSLHYKAF-GGVMLGSCSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C4C(C(O3)(CO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N'-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C35H36N6O7/c1-40(2)20-37-33-38-30-27(31(43)39-33)36-21-41(30)32-28-29(42)34(48-32,18-46-28)19-47-35(22-8-6-5-7-9-22,23-10-14-25(44-3)15-11-23)24-12-16-26(45-4)17-13-24/h5-17,20-21,28-29,32,42H,18-19H2,1-4H3,(H,38,39,43)/t28-,29+,32-,34-/m1/s1

Synonyms: N2-dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-guanosine; N'-(9-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide; N'-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-α-L-lyxofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide; 5'-DMT-2'-O-4'-C-Locked-G(dmf)

N2-iBu-O6-CE-DMT-2'-OMe-Gr

Description: N2-iBu-O6-CE-DMT-2'-OMe-Gr is a modified nucleoside used in oligonucleotide synthesis. It consists of an isobutyl (iBu) group attached to the N2 position of guanine, a cyanoethyl (CE) group attached to the O6 position of guanine, a dimethoxytrityl (DMT) protecting group, a methyl (Me) group at the 2' position of ribose, and a modified guanine (Gr). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-01000

CAS: 2227139-81-1

Molecular Formula: C39H42N6O8

Molecular Weight: 722.79

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.31±0.1 g/cm3

InChIKey: UBLMNMAUYACHGY-GONXPTGJSA-N

CanonicalSMILES: N#CCCOC1=NC(=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(O)C3OC)NC(=O)C(C)C

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-6-(2-cyanoethoxy)-9H-purin-2-yl)isobutyramide

InChI: InChI=1S/C39H42N6O8/c1-24(2)35(47)43-38-42-34-31(36(44-38)51-21-9-20-40)41-23-45(34)37-33(50-5)32(46)30(53-37)22-52-39(25-10-7-6-8-11-25,26-12-16-28(48-3)17-13-26)27-14-18-29(49-4)19-15-27/h6-8,10-19,23-24,30,32-33,37,46H,9,21-22H2,1-5H3,(H,42,43,44,47)/t30-,32-,33-,37-/m1/s1

Synonyms: N2-isobutyryl-O6-cyanoethyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine

DMT-2'-O-Me-5-Me-Cr

Description: DMT-2'-O-Me-5-Me-Cr is a modified nucleoside used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) protecting group, a methyl (Me) group at the 2' position of ribose, and methyl groups (Me) at the 5th position of cytosine. It is utilized in oligonucleotide synthesis to confer specific properties or functionalities to the resulting oligonucleotide, which can be crucial for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01001

CAS: 2940862-09-7

Molecular Formula: C32H35N3O7

Molecular Weight: 573.64

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Density: 1.28±0.1 g/cm3

Boiling Point: 734.1±70.0 °C at 760 mmHg

InChIKey: QTKGHPBFWOEEHR-NODMTMHWSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1N)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OC

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-5-methylpyrimidin-2-one

InChI: InChI=1S/C32H35N3O7/c1-20-18-35(31(37)34-29(20)33)30-28(40-4)27(36)26(42-30)19-41-32(21-8-6-5-7-9-21,22-10-14-24(38-2)15-11-22)23-12-16-25(39-3)17-13-23/h5-18,26-28,30,36H,19H2,1-4H3,(H2,33,34,37)/t26-,27-,28-,30-/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyl-cytidine; 5-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine