What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - RNA / BOC Sciences

Guanosine, dihydrate

Description: Guanosine dihydrate is a hydrated form of guanosine, a nucleoside composed of the nitrogenous base guanine attached to a ribose sugar molecule, with two water molecules associated. Guanosine is an essential building block of RNA and plays critical roles in cellular metabolism and signaling. In research and biochemical applications, guanosine dihydrate is used to study RNA synthesis, structure, and function. It is also valuable in exploring nucleotide interactions, enzyme activity related to nucleic acids, and cellular energy transfer processes. The dihydrate form ensures better solubility and stability in aqueous solutions, facilitating its use in various experimental and therapeutic contexts.

CAT: BRP-01523

CAS: 6010-14-6

Molecular Formula: C10H13N5O5.2H2O

Molecular Weight: 319.27

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: HNZAKYGFPANILR-LGVAUZIVSA-N

CanonicalSMILES: C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(NC2=O)N.O.O

IUPAC Name: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one;dihydrate

InChI: InChI=1S/C10H13N5O5.2H2O/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9;;/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19);2*1H2/t3-,5-,6-,9-;;/m1../s1

Synonyms: Guanosine, hydrate (1:2); Guanosine dihydrate; 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one dihydrate; 2-Amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one dihydrate; Guanine ribonucleoside dihydrate; Vernine dihydrate

Related CAS: 118-00-3 (anhydrous) ; 1143525-19-2 (monohydrate)

Cytidine, monohydrochloride

Description: Cytidine monohydrochloride is the hydrochloride salt form of cytidine, a nucleoside consisting of cytosine attached to a ribose sugar. Cytidine is a crucial component of RNA, playing a vital role in cellular processes such as protein synthesis and cell signaling. In its monohydrochloride form, cytidine is more soluble in water, which enhances its applicability in biochemical and pharmaceutical research. This compound is used to study RNA synthesis, metabolism, and the regulatory mechanisms of nucleic acids. Additionally, cytidine monohydrochloride is investigated for its potential therapeutic benefits, including neuroprotection, cognitive enhancement, and treatment of certain genetic disorders. The increased solubility and stability of the monohydrochloride form make it suitable for various experimental and clinical applications.

CAT: BRP-01524

CAS: 7244-51-1

Molecular Formula: C9H13N3O5.HCl

Molecular Weight: 279.68

Size	Price	Stock	Quantity
--	--	--

Inquiry

Melting Point: 205-206.5 °C

InChIKey: KCURWTAZOZXKSJ-IAIGYFSYSA-N

CanonicalSMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O.Cl

IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride

InChI: InChI=1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7-,8-;/m1./s1

Synonyms: Cytidine, hydrochloride (1:1); Cytosine, 1-β-D-ribofuranosyl-, monohydrochloride; Cytidine hydrochloride; 1-(β-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine hydrochloride; 1-β-D-Ribofuranosylcytosine hydrochloride; 4-Amino-1-β-D-ribofuranosyl-2(1H)-pyrimidinone hydrochloride; Cytosine riboside hydrochloride; β-D-Cytidine hydrochloride

Related CAS: 65-46-3 (free base)

3',5'-di-O-Benzoyl-2,2'-anhydro-L-uridine

Description: 3',5'-di-O-Benzoyl-2,2'-anhydro-L-uridine is a modified nucleoside derivative where uridine is chemically altered by the addition of benzoyl groups at the 3' and 5' positions and the formation of an anhydro bridge between the 2' positions of two ribose moieties. This modification impacts the nucleoside's structural and chemical properties, often used to study nucleoside behavior and interactions in biological systems. In research, this compound is utilized to investigate RNA synthesis, structure, and function, providing insights into nucleic acid chemistry and the effects of specific modifications on RNA activity. It is also valuable in developing nucleotide analogs for therapeutic and diagnostic purposes, exploring how such modifications can influence nucleic acid stability, binding affinity, and enzymatic processing. The benzoyl protection and anhydro linkage help enhance the molecule's stability and facilitate its use in various biochemical applications.

CAT: BRP-01525

CAS: 31615-96-0

Molecular Formula: C23H18N2O7

Molecular Weight: 434.40

Purity: ≥95% by HPLC

Size	Price	Stock	Quantity
--	--	--

Inquiry

Density: 1.48±0.1 g/cm3

Boiling Point: 589.0±60.0 °C at 760 mmHg

InChIKey: WLLCZAIADALVGH-FFGOWVMKSA-N

CanonicalSMILES: C1=CC=C(C=C1)C(=O)OCC2C(C3C(O2)N4C=CC(=O)N=C4O3)OC(=O)C5=CC=CC=C5

IUPAC Name: [(2S,4S,5S,6R)-5-benzoyloxy-10-oxo-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-4-yl]methyl benzoate

InChI: InChI=1S/C23H18N2O7/c26-17-11-12-25-20-19(32-23(25)24-17)18(31-22(28)15-9-5-2-6-10-15)16(30-20)13-29-21(27)14-7-3-1-4-8-14/h1-12,16,18-20H,13H2/t16-,18-,19+,20-/m0/s1

Synonyms: 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one, 3-(benzoyloxy)-2-[(benzoyloxy)methyl]-2,3,3a,9a-tetrahydro-, (2S,3S,3aR,9aS)-; (2S,3S,3aR,9aS)-3-(Benzoyloxy)-2-[(benzoyloxy)methyl]-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one; 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one, 2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-, dibenzoate (ester), stereoisomer; 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one, 3-(benzoyloxy)-2-[(benzoyloxy)methyl]-2,3,3a,9a-tetrahydro-, [2S-(2α,3β,3aβ,9aβ)]-; 3',5'-Di-O-benzoyl-O2,2'-anhydro-L-uridine

4'-C-Azido-2'-deoxy-2'-fluorocytidine

Description: 4'-C-Azido-2'-deoxy-2'-fluorocytidine is a modified nucleoside analog that has been studied for its potential antiviral properties. It belongs to a class of compounds that are designed to interfere with viral replication by targeting viral enzymes or RNA synthesis. The azido group (-N3) and fluorine substitution (-F) are modifications aimed at enhancing its activity or specificity against certain viruses.

CAT: BRP-01531

CAS: 1145869-35-7

Molecular Formula: C9H11FN6O4

Molecular Weight: 286.22

Purity: ≥95%

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: KTOLOIKYVCHRJW-JVZYCSMKSA-N

CanonicalSMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)F

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C9H11FN6O4/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2,5-7,17-18H,3H2,(H2,11,13,19)/t5-,6+,7-,9-/m1/s1

Synonyms: Cytidine, 4'-C-azido-2'-deoxy-2'-fluoro-; 4'-C-azido-2'-deoxy-2'-fluoro-cytidine; 4-amino-1-((2R,3R,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

2'-Fluoro-N2-dimethylformamidine-2'-deoxyguanosine

Description: 2'-Fluoro-N2-dimethylformamidine-2'-deoxyguanosine is a nucleoside analog that is modified to potentially inhibit viral replication. This compound typically incorporates a dimethylformamidine group (-N(CH3)2) at the N2 position of the guanine base and a fluorine substitution at the 2' position of the deoxyribose sugar. These modifications are often designed to enhance binding affinity or specificity for viral polymerases or reverse transcriptases, thereby interfering with viral nucleic acid synthesis.

CAT: BRP-01532

Molecular Formula: C13H17FN6O4

Molecular Weight: 340.32

Purity: ≥98% by HPLC

Appearance: White powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C

InChIKey: KBFMHYOHKLKPFN-GRIPGOBMSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)F

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C13H17FN6O4/c1-19(2)4-16-13-17-10-8(11(23)18-13)15-5-20(10)12-7(14)9(22)6(3-21)24-12/h4-7,9,12,21-22H,3H2,1-2H3,(H,17,18,23)/t6-,7-,9-,12-/m1/s1

Synonyms: dmf-2'-F-dG; N2-Dimethylformamidine-2'-Fluoro-2'-Deoxyguanosine; N'-(9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide; N2-dmf-2'-F-dG; 2'-F-dG(DMF)

3'-O-TBDMS-2'-F-dC(Ac)

Description: 3'-O-TBDMS-2'-F-dC(Ac) is a modified nucleoside where an acetyl group is attached to the N4 position of the cytidine base, and the ribose sugar is protected with a t-butyl-dimethylsilyl group at the 3' hydroxyl. Additionally, fluorine is substituted at the 2' position of the ribose. These modifications are commonly utilized in scientific research and pharmaceutical development to alter the nucleoside's stability, specificity, or biological activity for various applications.

CAT: BRP-01533

Molecular Formula: C17H28FN3O5Si

Molecular Weight: 401.51

Purity: ≥98% by HPLC

Appearance: White to light yellow powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C

InChIKey: VGWVGGIROFIQHX-NMFUWQPSSA-N

IUPAC Name: N-(1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C17H28FN3O5Si/c1-10(23)19-12-7-8-21(16(24)20-12)15-13(18)14(11(9-22)25-15)26-27(5,6)17(2,3)4/h7-8,11,13-15,22H,9H2,1-6H3,(H,19,20,23,24)/t11-,13-,14-,15-/m1/s1

Synonyms: N4-Acetyl-3'-O-(t-butyl-dimethylsilyl)-2'-fluoro-2'-deoxycytidine; N4-Ac-2'-F-3'-O-TBDMS-dC

3'-O-TBDMS-2'-F-dA(Bz)

Description: 3'-O-TBDMS-2'-F-dA(Bz) is a chemically modified nucleoside used in nucleic acid research and synthesis. This modification is employed to study nucleotide interactions, stability, and potential therapeutic applications by altering the chemical and biological properties of the nucleoside.

CAT: BRP-01534

CAS: 1244763-25-4

Molecular Formula: C23H30FN5O4Si

Molecular Weight: 487.61

Purity: ≥98% by HPLC

Appearance: White to light yellow powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C

Density: 1.32±0.1 g/cm3

InChIKey: VTZHRUXQJMHXQW-RPLGYBLPSA-N

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(CO)C(O[Si](C)(C)C(C)(C)C)C3F)C=4C=CC=CC4

IUPAC Name: N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C23H30FN5O4Si/c1-23(2,3)34(4,5)33-18-15(11-30)32-22(16(18)24)29-13-27-17-19(25-12-26-20(17)29)28-21(31)14-9-7-6-8-10-14/h6-10,12-13,15-16,18,22,30H,11H2,1-5H3,(H,25,26,28,31)/t15-,16-,18-,22-/m1/s1

Synonyms: Adenosine, N-benzoyl-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-; N-Benzoyl-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoroadenosine; N6-benzoyl-3'-O-(t-butyl-dimethylsilyl)-2'-fluorine-2'-deoxyadenosine; N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

3'-O-TBDMS-2'-F-dG(iBu)

Description: 3'-O-TBDMS-2'-F-dG(iBu) is a chemically modified nucleoside used in biochemical and pharmaceutical research. This compound is designed to alter the properties of guanosine for specific applications, such as enhancing stability, modifying base-pairing interactions, or studying enzymatic reactions involving guanine derivatives.

CAT: BRP-01535

CAS: 2382967-92-0

Molecular Formula: C20H32FN5O5Si

Molecular Weight: 469.59

Purity: ≥98% by HPLC

Appearance: White to off-white powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C

Density: 1.36±0.1 g/cm3

InChIKey: ACBLMVCONMEAIO-LZDVPDMXSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O[Si](C)(C)C(C)(C)C)F

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C20H32FN5O5Si/c1-10(2)16(28)24-19-23-15-13(17(29)25-19)22-9-26(15)18-12(21)14(11(8-27)30-18)31-32(6,7)20(3,4)5/h9-12,14,18,27H,8H2,1-7H3,(H2,23,24,25,28,29)/t11-,12-,14-,18-/m1/s1

Synonyms: 2'-F-3'-TBS-iBu-dG; N2-isobutyryl-3'-O-(t-butyl-dimethylsilyl)-2'-fluorine-2'-deoxyguanosine; Guanosine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-N-(2-methyl-1-oxopropyl)-; N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

5'-O-DMT-N4-Acetyl-2'-fluoro-5-methyl-2'-deoxycytidine

Description: 5'-O-DMT-N4-acetyl-2'-Fluoro-5-methyl-2'-deoxycytidine is a chemically modified nucleoside used in the synthesis of oligonucleotides to enhance their stability, specificity, and resistance to enzymatic degradation, making it valuable for developing therapeutic agents, such as antisense oligonucleotides and siRNAs, and for studying nucleic acid interactions and enzymatic processes in research.

CAT: BRP-01541

Molecular Formula: C33H34FN3O7

Molecular Weight: 603.65

Purity: >98%

Appearance: White to light yellow powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

InChIKey: STUFCHVUNHNWMI-BUVRPPHQSA-N

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C33H34FN3O7/c1-20-18-37(32(40)36-30(20)35-21(2)38)31-28(34)29(39)27(44-31)19-43-33(22-8-6-5-7-9-22,23-10-14-25(41-3)15-11-23)24-12-16-26(42-4)17-13-24/h5-18,27-29,31,39H,19H2,1-4H3,(H,35,36,38,40)/t27-,28-,29-,31-/m1/s1

Synonyms: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide; 5'-O-DMT-N4-Acetyl-2'-Fluoro-5-methyl-2'-deoxycytidine; N4-Acetyl-5'-O-DMT-2'-fluoro-5-methyl-2'-deoxycytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-5-methylcytidine; 5'-O-DMT-2'-F-5-Me-dC(Ac); N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine

N4-Acetyl-5-Iodo-2'-fluoro-2'-deoxycytidine

Description: N4-Acetyl-5-Iodo-2'-fluoro-2'-deoxycytidine is a chemically modified nucleoside used in oligonucleotide synthesis to enhance stability and resistance to enzymatic degradation due to its 2'-fluoro modification. The 5-iodo group allows for labeling and detection in various assays, while the N4-acetyl group protects the nucleobase during synthesis. This modified nucleoside is valuable for developing stable and specific therapeutic oligonucleotides, such as antisense oligonucleotides and siRNAs, and is also useful in research to study nucleic acid interactions and enzymatic processes.

CAT: BRP-01547

CAS: 2940869-29-2

Molecular Formula: C11H13FIN3O5

Molecular Weight: 413.14

Purity: ≥95%

Size	Price	Stock	Quantity
--	--	--

Inquiry

Density: 2.19±0.1 g/cm3

InChIKey: KDMMJHWZVCPNLN-FDDDBJFASA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1I)C2C(C(C(O2)CO)O)F

IUPAC Name: N-[1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C11H13FIN3O5/c1-4(18)14-9-5(13)2-16(11(20)15-9)10-7(12)8(19)6(3-17)21-10/h2,6-8,10,17,19H,3H2,1H3,(H,14,15,18,20)/t6-,7-,8-,10-/m1/s1

Synonyms: N4-Ac-5-I-2'-F-dC; N4-Ac-5-iodo-2'-fluoro-2'-dC

5'-O-(4,4'-Dimethoxytrityl)-N2-dimethylformamidine-2'-fluoro-2'-deoxyguanosine

Description: 5'-O-(4,4'-Dimethoxytrityl)-N2-dimethylformamidine-2'-fluoro-2'-deoxyguanosine is a chemically modified nucleoside used in oligonucleotide synthesis. This nucleoside features a 5'-O-(4,4'-Dimethoxytrityl) protecting group on the 5' hydroxyl, a N2-dimethylformamidine group at the guanosine base, and a 2'-fluoro modification on the deoxyribose sugar. It is employed to enhance stability and specificity in oligonucleotide design, particularly useful for developing therapeutic oligonucleotides like antisense oligonucleotides and siRNAs, and for conducting research on nucleic acid interactions and structure-function relationships.

CAT: BRP-01548

CAS: 2377586-41-7

Molecular Formula: C34H35FN6O6

Molecular Weight: 642.68

Purity: ≥98% by HPLC

Appearance: White powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.35±0.1 g/cm3

Boiling Point: 839.5±75.0 °C at 760 mmHg

InChIKey: YYXHJLCVHPOJDK-UUEOAETPSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)F

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C34H35FN6O6/c1-40(2)19-37-33-38-30-28(31(43)39-33)36-20-41(30)32-27(35)29(42)26(47-32)18-46-34(21-8-6-5-7-9-21,22-10-14-24(44-3)15-11-22)23-12-16-25(45-4)17-13-23/h5-17,19-20,26-27,29,32,42H,18H2,1-4H3,(H,38,39,43)/t26-,27-,29-,32-/m1/s1

Synonyms: N2-dmf-DMT-2'-F-dG; 5'-O-DMT-N2-dimethylformamide-2'-fluoro-2'-deoxyguanosine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-[(dimethylamino)methylene]guanosine; N'-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

N1-Methylene pivalate-N2-dibutylformamidine-2'-fluoro-guanosine

Description: N1-Methylene pivalate-N2-dibutylformamidine-2'-fluoro-guanosine is a modified guanosine nucleoside designed with protective groups at the N1 and N2 positions, alongside a 2'-fluoro modification on the ribose, enhancing stability and resistance to enzymatic degradation. This compound is pivotal in synthesizing modified oligonucleotides for biomedical research, improving nucleic acid performance in applications like gene therapy and molecular diagnostics.

CAT: BRP-01563

Molecular Formula: C25H39FN6O6

Molecular Weight: 538.62

Purity: ≥95% by HPLC

Appearance: White powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: OSNSETGWWMLVPD-VALFRTSSSA-N

IUPAC Name: (2-(((dibutylamino)methylene)amino)-9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-1-yl)methyl pivalate

InChI: InChI=1S/C25H39FN6O6/c1-6-8-10-30(11-9-7-2)13-28-24-29-20-18(21(35)32(24)15-37-23(36)25(3,4)5)27-14-31(20)22-17(26)19(34)16(12-33)38-22/h13-14,16-17,19,22,33-34H,6-12,15H2,1-5H3/t16-,17-,19-,22-/m1/s1

Synonyms: N1-methylene pivalate-N2-dibutylformamidine-2'-F-Gr

N4-Dibutylformamidine-2'-fluoro-deoxycytidine

Description: N4-Dibutylformamidine-2'-fluoro-deoxycytidine is a modified deoxycytidine nucleoside featuring a dibutylformamidine group at the N4 position and a 2'-fluoro modification on the deoxyribose sugar, enhancing stability and enzymatic resistance in oligonucleotide synthesis, crucial for biomedical applications like gene therapy and molecular diagnostics.

CAT: BRP-01564

Molecular Formula: C18H29FN4O4

Molecular Weight: 384.45

Purity: ≥95% by HPLC

Appearance: White powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: LALGLRQWGPDIIJ-MWQQHZPXSA-N

IUPAC Name: N,N-dibutyl-N'-(1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)formimidamide

InChI: InChI=1S/C18H29FN4O4/c1-3-5-8-22(9-6-4-2)12-20-14-7-10-23(18(26)21-14)17-15(19)16(25)13(11-24)27-17/h7,10,12-13,15-17,24-25H,3-6,8-9,11H2,1-2H3/t13-,15-,16-,17-/m1/s1

Synonyms: N4-dibutylformamidine-2'-F-dC

N2-Dibutylformamidine-2'-fluoro-guanosine

Description: N2-Dibutylformamidine-2'-fluoro-guanosine is a modified guanosine nucleoside with a dibutylformamidine group attached to the N2 position and a 2'-fluoro modification on the ribose, enhancing stability and enzymatic resistance in oligonucleotide synthesis, crucial for biomedical applications like gene therapy and molecular diagnostics.

CAT: BRP-01565

Molecular Formula: C19H29FN6O4

Molecular Weight: 424.48

Purity: ≥95% by HPLC

Appearance: White powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: XMWCLGNFTGLYEX-HOPMXRPOSA-N

IUPAC Name: N,N-dibutyl-N'-(9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)formimidamide

InChI: InChI=1S/C19H29FN6O4/c1-3-5-7-25(8-6-4-2)10-22-19-23-16-14(17(29)24-19)21-11-26(16)18-13(20)15(28)12(9-27)30-18/h10-13,15,18,27-28H,3-9H2,1-2H3,(H,23,24,29)/t12-,13-,15-,18-/m1/s1

Synonyms: N2-dibutylformamidine-2'-F-Gr

N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyguanosine

Description: N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyguanosine is a modified deoxyguanosine nucleoside with an acetyl group at the N2 position and a 2'-fluoro modification on the deoxyribose sugar, protected by a 4,4'-dimethoxytrityl (DMTr) group at the 5'-hydroxyl. This modification enhances stability and enzymatic resistance in oligonucleotide synthesis, essential for biomedical applications such as gene therapy and molecular diagnostics.

CAT: BRP-01566

CAS: 514830-14-9

Molecular Formula: C33H32FN5O7

Molecular Weight: 629.63

Purity: ≥95% by HPLC

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: JKJYAEOBEUHFSL-IAHIMPAPSA-N

CanonicalSMILES: CC(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)F

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]acetamide

InChI: InChI=1S/C33H32FN5O7/c1-19(40)36-32-37-29-27(30(42)38-32)35-18-39(29)31-26(34)28(41)25(46-31)17-45-33(20-7-5-4-6-8-20,21-9-13-23(43-2)14-10-21)22-11-15-24(44-3)16-12-22/h4-16,18,25-26,28,31,41H,17H2,1-3H3,(H2,36,37,38,40,42)/t25-,26-,28-,31-/m1/s1

Synonyms: N2-Ac-DMT-2'-F-dG; N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide; Guanosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroguanosine

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyguanosine, triethylamine salt

Description: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyguanosine, triethylamine salt is a modified deoxyguanosine nucleoside. It features an isobutyryl group at the N2 position, a 4,4'-dimethoxytrityl (DMTr) group at the 5'-hydroxyl, a succinate ester at the 3'-hydroxyl, and a 2'-fluoro modification on the deoxyribose sugar. This compound, in its triethylamine salt form, enhances stability and enzymatic resistance in oligonucleotide synthesis, crucial for applications such as gene therapy and molecular diagnostics.

CAT: BRP-01572

Molecular Formula: C45H55FN6O10

Molecular Weight: 858.95

Purity: ≥98% by HPLC

Appearance: White to off-white powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at RT

InChIKey: JAFGAGVWXBMKKQ-KYJIEUEGSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OC(=O)CCC(=O)O)C3F.N(CC)(CC)CC

IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C39H40FN5O10.C6H15N/c1-22(2)35(49)43-38-42-34-32(36(50)44-38)41-21-45(34)37-31(40)33(55-30(48)19-18-29(46)47)28(54-37)20-53-39(23-8-6-5-7-9-23,24-10-14-26(51-3)15-11-24)25-12-16-27(52-4)17-13-25;1-4-7(5-2)6-3/h5-17,21-22,28,31,33,37H,18-20H2,1-4H3,(H,46,47)(H2,42,43,44,49,50);4-6H2,1-3H3/t28-,31-,33-,37-;/m1./s1

Synonyms: N2-iBu-DMT-2'-F-dG-3'-succinate, TEA salt; 5'-DMT-2'-F-dG(iBu)-3'-succinate, TEA salt; 5'-DMT-NIBu-2'-F-dG-3'-succinate, TEA salt; 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-fluoro-deoxyguanosine-3'-O-succinate, triethylamine salt

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyadenosine, triethylamine salt

Description: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyadenosine, triethylamine salt is a modified deoxyadenosine nucleoside. It features a benzoyl group at the N6 position, a 4,4'-dimethoxytrityl (DMTr) group at the 5'-hydroxyl, a succinate ester at the 3'-hydroxyl, and a 2'-fluoro modification on the deoxyribose sugar. This compound, in its triethylamine salt form, enhances stability and enzymatic resistance in oligonucleotide synthesis, crucial for applications such as gene therapy and molecular diagnostics.

CAT: BRP-01573

Molecular Formula: C48H53FN6O9

Molecular Weight: 876.97

Purity: ≥98% by HPLC

Appearance: White to yellow powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C

InChIKey: RVRGUAZPBXTGSP-ARCYALSHSA-N

CanonicalSMILES: O=C(O)CCC(=O)OC1C(F)C(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=NC=6C(=NC=NC65)NC(=O)C=7C=CC=CC7.N(CC)(CC)CC

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C42H38FN5O9.C6H15N/c1-53-30-17-13-28(14-18-30)42(27-11-7-4-8-12-27,29-15-19-31(54-2)20-16-29)55-23-32-37(57-34(51)22-21-33(49)50)35(43)41(56-32)48-25-46-36-38(44-24-45-39(36)48)47-40(52)26-9-5-3-6-10-26;1-4-7(5-2)6-3/h3-20,24-25,32,35,37,41H,21-23H2,1-2H3,(H,49,50)(H,44,45,47,52);4-6H2,1-3H3/t32-,35-,37-,41-;/m1./s1

Synonyms: N6-Bz-DMT-2'-F-dA-3'-succinate, TEA salt; 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenoisne-3'-O-succinate, triethylamine salt; 5'-DMT-NBz-2'-dA-3'-succinate, TEA salt

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxycytidine, triethylamine salt

Description: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxycytidine, triethylamine salt is a modified deoxycytidine nucleoside. It features an acetyl group at the N4 position, a 4,4'-dimethoxytrityl (DMTr) group at the 5'-hydroxyl, a succinate ester at the 3'-hydroxyl, and a 2'-fluoro modification on the deoxyribose sugar. This compound, in its triethylamine salt form, enhances stability and enzymatic resistance in oligonucleotide synthesis, crucial for applications such as gene therapy and molecular diagnostics.

CAT: BRP-01574

Molecular Formula: C42H51FN4O10

Molecular Weight: 790.87

Purity: ≥98% by HPLC

Appearance: White to yellow powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C

InChIKey: GGLFHSJASYEZGI-PBJRKIRISA-N

CanonicalSMILES: CCN(CC)CC.CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OC(=O)CCC(=O)O)F

IUPAC Name: 4-[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluorooxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C36H36FN3O10.C6H15N/c1-22(41)38-29-19-20-40(35(45)39-29)34-32(37)33(50-31(44)18-17-30(42)43)28(49-34)21-48-36(23-7-5-4-6-8-23,24-9-13-26(46-2)14-10-24)25-11-15-27(47-3)16-12-25;1-4-7(5-2)6-3/h4-16,19-20,28,32-34H,17-18,21H2,1-3H3,(H,42,43)(H,38,39,41,45);4-6H2,1-3H3/t28-,32-,33-,34-;/m1./s1

Synonyms: N4-Ac-DMT-2'-F-dC-3'-succinate, TEA salt; 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-3'-O-succinate-2'-fluoro-deoxycytidine, triethylamine salt; 5'-DMT-N4-Ac-2'-F-dC-3'-succinate, TEA salt; Triethylamine 4-(((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)-4-oxobutanoate

Related CAS: 2746380-45-8 (free base)

5'-O-DMT-3'-O-succinate-2'-F-deoxyuridine, triethylamine salt

Description: 5'-O-DMT-3'-O-succinate-2'-F-deoxyuridine, triethylamine salt is a modified deoxyuridine nucleoside. It features a 5'-dimethoxytrityl (DMT) group at the 5'-hydroxyl, a succinate ester at the 3'-hydroxyl, and a fluorine atom (2'-F) modification on the deoxyribose sugar. This compound, in its triethylamine salt form, enhances stability and enzymatic resistance in oligonucleotide synthesis, making it valuable for applications such as gene therapy and molecular diagnostics.

CAT: BRP-01575

CAS: 2294880-79-6

Molecular Formula: C40H48FN3O10

Molecular Weight: 749.82

Purity: ≥98% by HPLC

Appearance: White to yellow powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Storage: Store at 2-8 °C

InChIKey: ZLUXDOSHTOAICW-GNGCXMSBSA-N

CanonicalSMILES: CCN(CC)CC.COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=CC(=O)NC5=O)F)OC(=O)CCC(=O)O

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C34H33FN2O10.C6H15N/c1-43-24-12-8-22(9-13-24)34(21-6-4-3-5-7-21,23-10-14-25(44-2)15-11-23)45-20-26-31(47-29(41)17-16-28(39)40)30(35)32(46-26)37-19-18-27(38)36-33(37)42;1-4-7(5-2)6-3/h3-15,18-19,26,30-32H,16-17,20H2,1-2H3,(H,39,40)(H,36,38,42);4-6H2,1-3H3/t26-,30-,31-,32-;/m1./s1

Synonyms: DMT-2'-F-dU-3'-succinate, TEA salt; 5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyuridine, triethylamine salt; Triethylamine 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)-4-oxobutanoate; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxyuridine 3'-O-succinate, triethylamine salt; 5'-DMT-2'-F-dU-3'-succinate, TEA salt

Related CAS: 2294880-67-2 (free base)

1-(2-Fluoro-2-deoxy-β-L-arabinofuranosyl)cytosine

Description: 1-(2-Fluoro-2-deoxy-β-L-arabinofuranosyl)cytosine is a modified nucleoside where cytosine is attached to a β-L-arabinofuranosyl sugar with a 2-fluoro-2-deoxy modification. This modification enhances the stability and alters the chemical properties of the nucleoside, making it useful in nucleic acid chemistry for applications such as nucleotide analog synthesis and structural studies.

CAT: BRP-01592

CAS: 163686-35-9

Molecular Formula: C9H12FN3O4

Molecular Weight: 245.21

Purity: ≥98%

Appearance: White to off-white powder

Size	Price	Stock	Quantity
--	--	--

Inquiry

Density: 1.82±0.1 g/cm3

Boiling Point: 500.1±60.0 °C at 760 mmHg

InChIKey: NVZFZMCNALTPBY-UCVXFZOQSA-N

CanonicalSMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)F

IUPAC Name: 4-amino-1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6+,7-,8-/m0/s1

Synonyms: 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-; L-2'-F-Ara-Cytidine; 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl) cytosine; 4-amino-1-((2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 4-Amino-1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-2(1H)-pyrimidinone