What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - RNA / BOC Sciences

6-Methoxy-9-(2-C-methyl-beta-D-ribofuranosyl)purine

Description: 6-Methoxy-9-(2-C-methyl-beta-D-ribofuranosyl)purine is a potent antiviral compound used in the research of viral infections, particularly those caused by herpes viruses. It exhibits a high selectivity index and low toxicity towards host cells, making it an effective option for suppressing viral replication. This nucleoside analogue inhibits the viral DNA polymerase, thus preventing viral DNA research and development and subsequent viral replication.

CAT: BRP-01797

CAS: 565450-78-4

Molecular Formula: C12H16N4O5

Molecular Weight: 296.28

Purity: ≥95%

Appearance: White foam solid

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Storage: Store at 2-8 °C

Density: 1.70±0.1 g/cm3 (Predicted)

Boiling Point: 588.7±60.0°C (Predicted)

InChIKey: HFOYSXHOPVYGPB-YUTYNTIBSA-N

CanonicalSMILES: CC1(C(C(OC1N2C=NC3=C2N=CN=C3OC)CO)O)O

IUPAC Name: (2R,3R,4R,5R)-5-(hydroxymethyl)-2-(6-methoxypurin-9-yl)-3-methyloxolane-3,4-diol

InChI: InChI=1S/C12H16N4O5/c1-12(19)8(18)6(3-17)21-11(12)16-5-15-7-9(16)13-4-14-10(7)20-2/h4-6,8,11,17-19H,3H2,1-2H3/t6-,8-,11-,12-/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(hydroxymethyl)-2-(6-methoxy-9H-purin-9-yl)-3-methyltetrahydrofuran-3,4-diol; 2'-C-Methyl-6-O-methylinosine; Inosine, 2'-C-methyl-6-O-methyl-; 9H-Purine, 6-methoxy-9-(2-C-methyl-β-D-ribofuranosyl)-

N2-iBu-2',3'-bis-O-TBDMS guanosine

Description: N2-iBu-2',3'-bis-O-TBDMS guanosine is a highly esteemed compound within the biomedical sector, manifesting remarkable utility in studying diverse afflictions including viral infections, cancers and neurological disorders.

CAT: BRP-01798

CAS: 79974-70-2

Molecular Formula: C26H47N5O6Si2

Molecular Weight: 581.85

Purity: ≥95%

Appearance: White to off-white foam solid

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Storage: Store at 2-8 °C

Density: 1.20±0.1 g/cm3 (Predicted)

Melting Point: 149-150 °C

InChIKey: VZMILHMVPGBTBQ-DYVMYPEFSA-N

Solubility: Soluble in Methanol

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-(9-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C26H47N5O6Si2/c1-15(2)21(33)29-24-28-20-17(22(34)30-24)27-14-31(20)23-19(37-39(11,12)26(6,7)8)18(16(13-32)35-23)36-38(9,10)25(3,4)5/h14-16,18-19,23,32H,13H2,1-12H3,(H2,28,29,30,33,34)/t16-,18-,19-,23-/m1/s1

Synonyms: Guanosine, 2',3'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-; 2',3'-Bis-O-(tert-butyldimethylsilyl)-N2-isobutyroylguanosine

1-(b-D-Xylofuranosyl)cytosine

Description: 1-(b-D-Xylofuranosyl)cytosine, a nucleoside analog, exhibits remarkable potency as an antiviral agent, finding utility in combating viral infections induced by pathogens such as Herpes simplex virus, Varicella-zoster virus, and Epstein-Barr virus. By impeding viral DNA synthesis, this compound serves as a pivotal tool in thwarting viral replication.

CAT: BRP-01801

CAS: 3530-56-1

Molecular Formula: C9H13N3O5

Molecular Weight: 243.22

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at 2-8 °C

Density: 1.89±0.1 g/cm3

Melting Point: 237-238°C

Boiling Point: 545.7±60.0°C at 760 mmHg

InChIKey: UHDGCWIWMRVCDJ-PXBUCIJWSA-N

CanonicalSMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6+,7-,8-/m1/s1

Synonyms: Xylocytidine; Xylo-cytidine; 4-Amino-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 4-Amino-1-β-D-xylofuranosyl-2(1H)-pyrimidinone; Cytosine, 1-β-D-xylofuranosyl-; 1-(β-D-Xylofuranosyl)cytosine

6-Methyl-9-(beta-D-ribofuranosyl)-9H-purine

Description: It is a natural antibiotic, antifungal and antiviral agent.

CAT: BRP-01805

CAS: 14675-48-0

Molecular Formula: C11H14N4O4

Molecular Weight: 266.25

Purity: ≥95%

Appearance: White solid

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Storage: Store at -20°C

Density: 1.81±0.1 g/cm3 (Predicted)

Melting Point: 209-210°C

Boiling Point: 590.4±60.0°C (Predicted)

InChIKey: FIGBCBGMUIGJBD-PNHWDRBUSA-N

CanonicalSMILES: CC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O

IUPAC Name: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-methylpurin-9-yl)oxolane-3,4-diol

InChI: InChI=1S/C11H14N4O4/c1-5-7-10(13-3-12-5)15(4-14-7)11-9(18)8(17)6(2-16)19-11/h3-4,6,8-9,11,16-18H,2H2,1H3/t6-,8-,9-,11-/m1/s1

Synonyms: 6-D-MPR; 9H-Purine, 6-methyl-9-b-D-ribofuranosyl-; (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3,4-diol; 6-Methylpurine-beta-D-ribonucleoside; 6-Methyl-9-β-D-ribofuranosylpurine; NSC 101619; 6-Methylpurine ribonucleoside

3'-O-TBDMS-N2-Isobutyryl-Guanosine

Description: 3'-O-TBDMS-N2-Isobutyryl-Guanosine is an impressive and versatile nucleotide analog with burgeoning potential. Frequently deployed as a biochemical tool in modified RNA synthesis, it also boasts functionality as a viral RNA-dependent RNA polymerase substrate. A captivatingly multifaceted compound, studies to date suggest its exceptional capacity to combat viral infections, including Hepatitis C and Zika virus.

CAT: BRP-01807

CAS: 1237684-87-5

Molecular Formula: C20H33N5O6Si

Molecular Weight: 467.60

Purity: ≥95% by HPLC

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Density: 1.37±0.1 g/cm3

InChIKey: MCKWRFWFUTWNLD-XWXWGSFUSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O[Si](C)(C)C(C)(C)C)O

IUPAC Name: N-(9-((2R,3R,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C20H33N5O6Si/c1-10(2)16(28)23-19-22-15-12(17(29)24-19)21-9-25(15)18-13(27)14(11(8-26)30-18)31-32(6,7)20(3,4)5/h9-11,13-14,18,26-27H,8H2,1-7H3,(H2,22,23,24,28,29)/t11-,13-,14-,18-/m1/s1

Synonyms: Guanosine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-; 3'-O-[Dimethyl(2-methyl-2-propanyl)silyl]-N-isobutyrylguanosine; 3'-O-[(1,1-Dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)guanosine

5'-DMT-2'-TBDMS-N6-Me-rA

Description: 5'-DMT-2'-TBDMS-N6-Me-rA is an extraordinary modified RNA nucleoside, allowing for unrivaled applications in the intricate domain of drug research and development, explicitly targeting RNA-based ailments encompassing malignant neoplasms, viral afflictions is as well as hereditary anomalies.

CAT: BRP-01808

CAS: 588698-75-3

Molecular Formula: C38H47N5O6Si

Molecular Weight: 697.91

Purity: ≥98% by HPLC

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Density: 1.21±0.1 g/cm3

Boiling Point: 797.8±70.0 °C at 760 mmHg

InChIKey: KEEBYCOQGORZDK-QGGAYTEESA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O

IUPAC Name: (2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-[6-(methylamino)purin-9-yl]oxolan-3-ol

InChI: InChI=1S/C38H47N5O6Si/c1-37(2,3)50(7,8)49-33-32(44)30(48-36(33)43-24-42-31-34(39-4)40-23-41-35(31)43)22-47-38(25-12-10-9-11-13-25,26-14-18-28(45-5)19-15-26)27-16-20-29(46-6)21-17-27/h9-21,23-24,30,32-33,36,44H,22H2,1-8H3,(H,39,40,41)/t30-,32-,33-,36-/m1/s1

Synonyms: 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N6-methyladenosine; N6-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-t-butyldimethylsilyladenosine; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-N-methyladenosine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-methyladenosine; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-dimethyl(tert-butyl)silyl-N6-methyladenosine

5'-O-DMT-2'-O-TBDMS-Inosine

Description: 5'-O-DMT-2'-O-TBDMS-Inosine is a modified nucleoside used in the synthesis of deoxyribonucleic acid or nucleic acid.

CAT: BRP-01809

CAS: 127212-34-4

Molecular Formula: C37H44N4O7Si

Molecular Weight: 684.85

Purity: ≥98% by HPLC

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Density: 1.24±0.1 g/cm3 (Predicted)

Boiling Point: 831.1±65.0°C (Predicted)

InChIKey: OPTOBSYBLQDPQN-QSYCCZFCSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O

IUPAC Name: 9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-ol

InChI: InChI=1S/C37H44N4O7Si/c1-36(2,3)49(6,7)48-32-31(42)29(47-35(32)41-23-40-30-33(41)38-22-39-34(30)43)21-46-37(24-11-9-8-10-12-24,25-13-17-27(44-4)18-14-25)26-15-19-28(45-5)20-16-26/h8-20,22-23,29,31-32,35,42H,21H2,1-7H3,(H,38,39,43)/t29-,31-,32-,35-/m1/s1

Synonyms: 5'-DMT-2'-tBDSilyl Inosine; 5'-DMT-2'-TBDMS-rI; Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one; 2'-O-(tert-Butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)inosine

N-Benzoyl-5'-O-tritylcytidine

Description: N-Benzoyl-5'-O-tritylcytidine, a nucleoside analogue, has garnered interest in the development of antiviral agents targeting RNA viruses like hepatitis C and HIV. Its potential in the treatment of solid tumors including lung and breast cancer has also been observed. Moreover, this compound's structural attributes make it a valuable asset in the synthesis of modified nucleosides for a slew of biomedical uses.

CAT: BRP-01810

CAS: 41092-41-5

Molecular Formula: C35H31N3O6

Molecular Weight: 589.65

Purity: ≥98% by HPLC

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Density: 1.30±0.1 g/cm3 (Predicted)

InChIKey: VPHGCMRVEOZXRC-CSEBVFCESA-N

CanonicalSMILES: C1=CC=C(C=C1)C(=O)NC2=NC(=O)N(C=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)O)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C35H31N3O6/c39-30-28(44-33(31(30)40)38-22-21-29(37-34(38)42)36-32(41)24-13-5-1-6-14-24)23-43-35(25-15-7-2-8-16-25,26-17-9-3-10-18-26)27-19-11-4-12-20-27/h1-22,28,30-31,33,39-40H,23H2,(H,36,37,41,42)/t28-,30-,31-,33-/m1/s1

Synonyms: 5'-Trt-N4-Bz-rC; N-Benzoyl-5'-O-(triphenylmethyl)-Cytidine; 5'-O-trityl-4-N-benzoylcytidine; 5'-O-Trt-N4-Bz-rC; Cytidine, N-benzoyl-5'-O-(triphenylmethyl)-; N6-Benzoyl-5'-O-tritylcytidine

N-Acetyl-5'-O-tritylcytidine

Description: N-Acetyl-5'-O-tritylcytidine, a nucleoside analog commonly utilized in antiviral research, boasts potential as an agent to tackle various viral diseases, such as hepatitis B and C. Its selective inhibition of viral DNA synthesis is sparking interest in possible future drug development, and serves as a subject of study to further investigate antiviral drug efficacy and mechanisms of action.

CAT: BRP-01811

CAS: 31085-52-6

Molecular Formula: C30H29N3O6

Molecular Weight: 527.58

Purity: ≥98% by HPLC

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Density: 1.32±0.1 g/cm3

InChIKey: VJLDBTRYQIPAQK-YULOIDQLSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)O)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C30H29N3O6/c1-20(34)31-25-17-18-33(29(37)32-25)28-27(36)26(35)24(39-28)19-38-30(21-11-5-2-6-12-21,22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-18,24,26-28,35-36H,19H2,1H3,(H,31,32,34,37)/t24-,26-,27-,28-/m1/s1

Synonyms: 5'-Trt-N4-Ac-rC; 5'-O-Trt-N4-Ac-rC; N-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide; N-Acetyl-5'-O-(triphenylmethyl)cytidine; Acetamide, N-[1,2-dihydro-2-oxo-1-(5-O-trityl-β-D-ribofuranosyl)-4-pyrimidinyl]-

5'-tert-Butyldimethylsilyloxy-N4-acetyl-5-iodo-cytidine

Description: 5'-tert-butyldimethylsilyloxy-N4-acetyl-5-iodo-cytidine, a pharmaceutical intermediate renowned for its antiviral properties, is widely employed in the production of antiviral drugs. Its efficacy has been empirically proven against herpes simplex virus, cytomegalovirus, and varicella-zoster virus. Additionally, this product serves as a potent weapon in the biomedical industry's battle against numerous other viral infections that threaten public health.

CAT: BRP-01812

Molecular Formula: C17H28IN3O6Si

Molecular Weight: 525.42

Purity: ≥97% by HPLC

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InChIKey: FKZFVKBOIWTSKS-RGCMKSIDSA-N

IUPAC Name: N-(1-((2R,3R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-iodo-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C17H28IN3O6Si/c1-9(22)19-14-10(18)7-21(16(25)20-14)15-13(24)12(23)11(27-15)8-26-28(5,6)17(2,3)4/h7,11-13,15,23-24H,8H2,1-6H3,(H,19,20,22,25)/t11-,12-,13-,15-/m1/s1

Synonyms: 5'-O-TBDMS-N4-acetyl-5-iodo-cytidine

N-Benzoyl-5'-O-trityladenosine

Description: N-Benzoyl-5'-O-trityladenosine, a chemical compound frequently utilized as an intermediate in pharmaceutical synthesis, is well known for its antitumor, antiviral, and anti-inflammatory properties. Its rendering abilities facilitate the propagation of biorelevant molecules such as acyclovir and ganciclovir and construction of nucleoside analogs vital in the management of cancer and other viral illnesses.

CAT: BRP-01813

CAS: 18404-90-5

Molecular Formula: C36H31N5O5

Molecular Weight: 613.67

Purity: ≥98% by HPLC

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Density: 1.36±0.1 g/cm3

InChIKey: CLQLOYVVKMWBIY-JYYIKNSZSA-N

CanonicalSMILES: C1=CC=C(C=C1)C(=O)NC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)COC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)O)O

IUPAC Name: N-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C36H31N5O5/c42-30-28(21-45-36(25-15-7-2-8-16-25,26-17-9-3-10-18-26)27-19-11-4-12-20-27)46-35(31(30)43)41-23-39-29-32(37-22-38-33(29)41)40-34(44)24-13-5-1-6-14-24/h1-20,22-23,28,30-31,35,42-43H,21H2,(H,37,38,40,44)/t28-,30-,31-,35-/m1/s1

Synonyms: 5'-Trt-N6-Bz-rA; N-Benzoyl-5'-O-(triphenylmethyl)-Adenosine; 5'-O-Trt-N6-Bz-rA; Adenosine, N-benzoyl-5'-O-(triphenylmethyl)-; Benzamide, N-[9-(5-O-trityl-β-D-ribofuranosyl)-9H-purin-6-yl]-; N-Benzoyl-5'-O-(triphenylmethyl)adenosine; 5'-O-Trityl-N6-benzoyladenosine

5'-O-Trityl Uridine

Description: 5'-O-Trityl Uridine, a paramount compound extensively employed in the biomedical domain, demonstrates outstanding prowess in the orchestration of RNA molecule research and development. This remarkable entity assumes the vital responsibility of safeguarding uridine throughout chemical reactions, thus enabling the discriminatory alteration of alternative functional groups. Remarkably adaptable, this multifaceted compound showcases unbounded utility in advancing RNA-centric therapeutics and facilitating comprehensive investigations into the intricate intricacies of RNA's overarching structure and intrinsic functioning.

CAT: BRP-01814

CAS: 6554-10-5

Molecular Formula: C28H26N2O6

Molecular Weight: 486.52

Purity: ≥98% by HPLC

Appearance: White Solid

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Storage: Store at -20°C under inert atmosphere

Density: 1.355±0.06 g/cm3

Melting Point: 207-208 °C

InChIKey: YQHCGMPQZCIQPS-VNSJUHMKSA-N

Solubility: Soluble in Dichloromethane, Ethanol, Methanol

CanonicalSMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC4C(C(C(O4)N5C=CC(=O)NC5=O)O)O

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C28H26N2O6/c31-23-16-17-30(27(34)29-23)26-25(33)24(32)22(36-26)18-35-28(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-17,22,24-26,32-33H,18H2,(H,29,31,34)/t22-,24-,25-,26-/m1/s1

Synonyms: 5'-Trt-dU; 5'-O-Trityluridine; 5'-O-Triphenylmethyluridine; NSC 97038; 5'-O-Trityl-D-uridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

5'-Trt-N2-ibu-rG

Description: 5'-Trt-N2-ibu-rG, a nucleoside analog, exhibits strong potential as an effective anticancer agent, as it has been demonstrated to impede the growth and spread of certain cancer cell types, including leukemia and breast cancer. The mechanism behind its tumor suppression lies in its specific targeting of the RNA polymerase II enzyme, a key factor in the transcription of cancer-promoting genes, thus providing a promising avenue for chemotherapy.

CAT: BRP-01815

Molecular Formula: C33H32N5O6

Molecular Weight: 595.65

Purity: ≥98% by HPLC

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InChIKey: BBHYMFPOKIVUSI-YUGARCTCSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)O)O

IUPAC Name: N-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C33H33N5O6/c1-20(2)29(41)36-32-35-28-25(30(42)37-32)34-19-38(28)31-27(40)26(39)24(44-31)18-43-33(21-12-6-3-7-13-21,22-14-8-4-9-15-22)23-16-10-5-11-17-23/h3-17,19-20,24,26-27,31,39-40H,18H2,1-2H3,(H2,35,36,37,41,42)/t24-,26-,27-,31-/m1/s1

Synonyms: 5'-O-Trt-N2-ibu-rG; N-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

5'-O-Tritylinosine

Description: KIN59 is a purine riboside derivative that suppresses thymidine phosphorylase (TPase). TPase is an enzyme catalyzing the reversible phosphorolysis of pyrimidine deoxynucleosides to 2-deoxy-d-ribose-1-phosphate and their respective pyrimidine bases. KIN59 noncompetitively inhibits TPase-induced angiogenesis in the chorioallantoic membrane assay.

CAT: BRP-01816

CAS: 4152-77-6

Molecular Formula: C29H26N4O5

Molecular Weight: 510.55

Purity: ≥98% by HPLC

Appearance: Crystalline Solid

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Storage: Store at -20°C

Density: 1.40±0.1 g/cm3

Melting Point: 207-210 °C

Boiling Point: 813.6±65.0 °C at 760 mmHg

InChIKey: YEPZMZDCXFRHCL-ZYWWQZICSA-N

Solubility: Soluble in DMF, DMSO, Ethanol

CanonicalSMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC4C(C(C(O4)N5C=NC6=C5N=CNC6=O)O)O

IUPAC Name: 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]-1H-purin-6-one

InChI: InChI=1S/C29H26N4O5/c34-24-22(38-28(25(24)35)33-18-32-23-26(33)30-17-31-27(23)36)16-37-29(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17-18,22,24-25,28,34-35H,16H2,(H,30,31,36)/t22-,24-,25-,28-/m1/s1

Synonyms: 5'-Trt-rI; (2R,3R,4S,5R)-9-(3,4-Dihydroxy-5-trityloxymethyl-tetrahydrofuran-2-yl)-1,9-dihydropurin-6-one; KIN-59; Inosine, 5'-O-(triphenylmethyl)-; 5'-O-(triphenylmethyl)-inosine; 5'-O-(Triphenylmethyl)inosine; Inosine, 5'-O-trityl-; KIN59; KIN 59

2'-O-Methyl-5'-O-DMTr-5-iodouridine

Description: 5'-O-(Dimethoxytrityl)-5-iodo-2'-O-methyluridine is a reagent used in the synthesis of oligonucleotides (ODNs) containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridine which is resistant to nucleolytic hydrolysis.

CAT: BRP-01817

CAS: 588691-24-1

Molecular Formula: C31H31IN2O8

Molecular Weight: 686.49

Purity: ≥95%

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Density: 1.58±0.1 g/cm3

InChIKey: VYNNFLLSYDWMCJ-LTGLEFCMSA-N

CanonicalSMILES: COC1C(C(OC1N2C=C(C(=O)NC2=O)I)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione

InChI: InChI=1S/C31H31IN2O8/c1-38-22-13-9-20(10-14-22)31(19-7-5-4-6-8-19,21-11-15-23(39-2)16-12-21)41-18-25-26(35)27(40-3)29(42-25)34-17-24(32)28(36)33-30(34)37/h4-17,25-27,29,35H,18H2,1-3H3,(H,33,36,37)/t25-,26-,27-,29-/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-5-Iodo-2'-O-Methyluridine; 5'-O-(Dimethoxytrityl)-5-iodo-2'-O-methyluridine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-iodo-2'-O-methyl-uridine; 1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione; 5-Iodo-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-Uridine

5'-O-(4,4'-Dimethoxytrityl)-N4-Acetyl-5-Iodo-Cytidine

Description: 5'-O-(4,4'-Dimethoxytrityl)-N4-Acetyl-5-Iodo-Cytidine, a nucleoside analog utilized in the management of neoplastic diseases, has demonstrated its efficacy by obstructing DNA synthesis, thereby hindering tumor cell progression. With well-established usage in biomedical studies, this product is a valuable resource for comprehending DNA replication as well as repair mechanisms and developing innovative anticancer therapeutics.

CAT: BRP-01818

Molecular Formula: C32H32IN3O8

Molecular Weight: 713.52

Purity: ≥98% by HPLC

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InChIKey: WQTCLOQRQHSBBY-NODMTMHWSA-N

IUPAC Name: N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-iodo-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C32H32IN3O8/c1-19(37)34-29-25(33)17-36(31(40)35-29)30-28(39)27(38)26(44-30)18-43-32(20-7-5-4-6-8-20,21-9-13-23(41-2)14-10-21)22-11-15-24(42-3)16-12-22/h4-17,26-28,30,38-39H,18H2,1-3H3,(H,34,35,37,40)/t26-,27-,28-,30-/m1/s1

Synonyms: 5'-DMT-Ac-5-I-rC; 5'-O-DMT-5-I-rC(Ac); N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-iodocytidine

5'-O-DMT-5-iodouridine

Description: 5'-O-DMT-5-iodouridine, an extraordinary compound thriving in the biomedical realm, plays a pivotal role within the pharmaceutical sphere. Facilitating the evolution of nucleoside-based medicinal concoctions, this remarkable product revolutionizes the therapeutic landscape, championing the battle against afflictions such as viral infections and particular variants of malignancy. Its inherent molecular idiosyncrasies position it as an invaluable asset, empowering the arsenal of biomedicine by propelling precision healthcare and enabling targeted remedial interventions.

CAT: BRP-01819

CAS: 158728-68-8

Molecular Formula: C30H29IN2O8

Molecular Weight: 672.46

Purity: ≥95%

Appearance: White to Off-white Crystalline Powder

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Storage: Store at 2-8°C

Density: 1.64±0.1 g/cm3

InChIKey: GOLQPGCNIAQGQO-IYUNARRTSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=C(C(=O)NC5=O)I)O)O

IUPAC Name: 1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione

InChI: InChI=1S/C30H29IN2O8/c1-38-21-12-8-19(9-13-21)30(18-6-4-3-5-7-18,20-10-14-22(39-2)15-11-20)40-17-24-25(34)26(35)28(41-24)33-16-23(31)27(36)32-29(33)37/h3-16,24-26,28,34-35H,17H2,1-2H3,(H,32,36,37)/t24-,25-,26-,28-/m1/s1

Synonyms: 5'-O-(4,4'-Dimethyltrityl)-5-iodouridine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-iodouridine; 1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-5-iodo-1H-pyrimidine-2,4-dione; 5'-O-DMT-5-I-rU

5'-O-DMT-2'-O-methyl-N6-phenoxyacetyladenosine

Description: 5'-O-DMT-2'-O-methyl-N6-phenoxyacetyladenosine is an immensely powerful biomedical compound, used in the research of inflammatory disorders and autoimmune diseases. This exquisite molecule, through its adept nature, selectively engages receptors and signaling pathways, exuding anti-inflammatory prowess.

CAT: BRP-01820

CAS: 128219-81-8

Molecular Formula: C40H39N5O8

Molecular Weight: 717.77

Purity: ≥98% by HPLC

Appearance: White to pale yellow powder

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Storage: Store at 2-8°C

Density: 1.32±0.1 g/cm3

InChIKey: WXVUPMVJIZZBQJ-FCOKYAGUSA-N

CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]purin-6-yl]-2-phenoxyacetamide

InChI: InChI=1S/C40H39N5O8/c1-48-29-18-14-27(15-19-29)40(26-10-6-4-7-11-26,28-16-20-30(49-2)21-17-28)52-22-32-35(47)36(50-3)39(53-32)45-25-43-34-37(41-24-42-38(34)45)44-33(46)23-51-31-12-8-5-9-13-31/h4-21,24-25,32,35-36,39,47H,22-23H2,1-3H3,(H,41,42,44,46)/t32-,35-,36-,39-/m1/s1

Synonyms: 5'-DMT-2'-(O-Methyl) Adenosine (n-PAC); 5'-O-(4,4'-Dimethoxytrityl)-N6-Phenoxyacetyl-2'-O-methyl-Adenosine; 5'-O-DMT-N6-PAc-2'-OMe-rA; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-phenoxyacetyl)adenosine; 5'-O-DMT-2'-O-methyl-N6-phenoxyacetyladenosine; 5'-O-DMT-2'-O-methyl-N6-phenoxyacetyl-D-adenosine; 5'-O-DMT-2'-OMe-N6-Pac-rA

5'-O-DMT-3'-O-TBDMS-2'-O-methyl-Uridine

Description: 5'-O-DMT-3'-O-TBDMS-2'-O-methyl-Uridine is a pivotal compound in nucleotide biosynthesis, deemed indispensable in the production of oligonucleotides used for gene expression research and DNA sequencing. Its comprehensive applicability also extends to the creation of antivirals that combat diseases, encompassing cancer and hepatitis C, and thus, embodies an essential tool in the arsenal of medicinal chemists.

CAT: BRP-01821

CAS: 171268-85-2

Molecular Formula: C37H46N2O8Si

Molecular Weight: 674.87

Purity: ≥98% by HPLC

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Density: 1.21±0.1 g/cm3

InChIKey: ZWQRHEIYDFEUMS-DWNQJFHRSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C37H46N2O8Si/c1-36(2,3)48(7,8)47-32-30(46-34(33(32)44-6)39-23-22-31(40)38-35(39)41)24-45-37(25-12-10-9-11-13-25,26-14-18-28(42-4)19-15-26)27-16-20-29(43-5)21-17-27/h9-23,30,32-34H,24H2,1-8H3,(H,38,40,41)/t30-,32-,33-,34-/m1/s1

Synonyms: 5'-O-DMT-3'-O-TBDMS-2'-OMe-U; 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyl-

5'-O-DMT-2'-O-Propylphthalimido-5-Methy-Uridine

Description: 5'-O-DMT-2'-O-Propylphthalimido-5-Methy-Uridine is a highly specialized synthetic nucleoside compound that has garnered significant attention in the scientific community due to its antiviral activity against HIV-1 and HSV-2. Its unique chemical structure allows for targeted treatment of viral infections, making it an incredibly valuable tool in the ongoing fight against these debilitating diseases. Additionally, recent studies have shown promising results in its potential use as a therapy for leukemia, highlighting its versatility as a research tool. Researchers in the field of virology and oncology alike continue to explore the multifaceted potential of 5'-O-DMT-2'-O-Propylphthalimido-5-Methy-Uridine, making it a pivotal molecule in the world of medical research.

CAT: BRP-01822

Molecular Formula: C42H41N3O10

Molecular Weight: 747.80

Purity: ≥98% by HPLC

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Density: 1.3±0.1 g/cm3

Boiling Point: 892.5±75.0°C at 760 mmHg

InChIKey: CJZDRODFMDMJFQ-NFCWHMTKSA-N

CanonicalSMILES: Cc1cn(c(=O)nc1O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(c3ccccc3)(c4ccc(cc4)OC)c5ccc(cc5)OC)O)OCCCN6C(=O)c7ccccc7C6=O

IUPAC Name: 2-(3-(((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)propyl)isoindoline-1,3-dione

InChI: InChI=1S/C42H41N3O10/c1-26-24-45(41(50)43-37(26)47)40-36(53-23-9-22-44-38(48)32-12-7-8-13-33(32)39(44)49)35(46)34(55-40)25-54-42(27-10-5-4-6-11-27,28-14-18-30(51-2)19-15-28)29-16-20-31(52-3)21-17-29/h4-8,10-21,24,34-36,40,46H,9,22-23,25H2,1-3H3,(H,43,47,50)/t34-,35-,36-,40-/m1/s1

Synonyms: 5'-O-DMT-2'-O-Propylphthalimido-5-Me-U; 1-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2-O-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-β-D-ribofuranosyl}-4-hydroxy-5-methyl-2(1H)-pyrimidinone; 2(1H)-Pyrimidinone, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-β-D-ribofuranosyl]-4-hydroxy-5-methyl-