Glycomimetic-Oligonucleotide Conjugation

BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with glycomimetics. We have the capability and confidence to meet your needs for novel conjugates.

What is Glycomimetic-Oligonucleotide Conjugation?

Glycomimetics are synthetic molecules that mimic the structure and function of carbohydrates. The combination of glycomimetics with oligonucleotides allows the combination of their respective properties, thus enabling the development of hybrid molecules with both the targeting ability of glycomimetics and the gene regulation or gene silencing properties of oligonucleotides.

Figure 1. Examples of glycomimetics.(Tamburrini, A; et al, 2019)

• Preparation of Glycomimetic-Oligonucleotide Conjugation

Achieving glycomimetic-oligonucleotide binding involves a series of chemical reactions and strategies to covalently link the glycomimetic molecule to the oligonucleotide. The specific methods used to prepare sugar mimics and oligonucleotides can vary depending on the desired application and the chemistry of the molecules involved. There are a number of binding strategies that can be employed, including reactive ester or acid-base reactions, click chemistry, peptide coupling, and solid-phase synthesis to obtain the desired sugar mimetic-oligonucleotide conjugates.

• Application of Glycomimetic-Oligonucleotide Conjugation

Glycomimetic-oligonucleotide conjugation has a wide range of applications in biotechnology and medicine, such as targeted gene modulation, drug delivery systems, vaccine development, immunotherapy, diagnostic tools, biomaterials and tissue engineering scaffolds. The development and optimization of specific coupling strategies and applications are currently a hot research area.

Introduction of Glycomimetic-Oligonucleotide Conjugation Services

• What Are Our Glycomimetic-Oligonucleotide Conjugation Services?

1. Oligonucleotide Synthesis: BOC Sciences offers custom oligonucleotide synthesis services while you only need to request the sequence.
2. Glycomimetic Preparation: After you have selected the right Glycomimetics for your project, BOC Sciences can be responsible for the design and carry out the pre-coupling modification steps.
3. Conjugation Method Selection: BOC Sciences will advise you on the appropriate conjugation strategy for your needs.
4. Conjugation Purification & Identification: BOC Sciences has optimized purification and evaluation methods to ensure the quality of the conjugations.
5. Detailed Analytical Reports: BOC Sciences will provide you with a detailed conjugate-based identification report at the end to ensure high quality delivery.

Figure 2. Service flow of glycomimetic-oligonucleotide conjugation.

• Why Choose Our Glycomimetic-Oligonucleotide Conjugation Services?

1. BOC Sciences guarantees the ultra-high purity of the products of our glycomimetic-oligonucleotide conjugation service by using top-quality glycomimetic and customizable oligonucleotides.
2. BOC Sciences' optimized and well-tested processes ensure fast turnaround times and improve overall efficiency.
3. BOC Sciences offers flexible and customizable options for glycomimetic-oligonucleotide conjugation services to fully meet the needs of different applications.
4. BOC Sciences offers competitive pricing on the premise of ensuring high quality of glycomimetic-oligonucleotide conjugates.

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Glycomimetic-Oligonucleotide Conjugation

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