Nanoparticle-Oligonucleotide Conjugation

BOC Sciences is committed to bringing new ideas to the pharmaceutical field through bioconjugation technology, relying on state-of-the-art manufacturing facilities and extensive experience in conjugation technology. We offer high-quality oligonucleotide and nanoparticle conjugation services and are fully confident that we can meet your needs for novel conjugates.

Overview of Nanoparticle-Oligonucleotide Conjugation

Nanoparticle-oligonucleotide conjugation is formed by attaching or binding oligonucleotides to nanoparticles. This covalent bonding or van der Waals force based bonding creates a hybrid structure that combines the unique properties of nanoparticles and oligonucleotides and has a wide range of applications in various fields such as nanomedicine, diagnostics and materials science.

Figure 1. Lipid-based nanoparticles loaded with RNAi.

• How to Prepare Nanoparticle-Oligonucleotide Conjugation

The preparation methods for nanoparticle-oligonucleotide conjugation would vary depending on the type of nanoparticle and oligonucleotide involved. The main conjugation methods include covalent bonding, electrostatic interactions and hybridisation-based methods.

1. Covalent bonding usually involves the use of crosslinkers or reactive functional groups on the nanoparticles and oligonucleotides.
2. Electrostatic interactions can be utilised when nanoparticles and oligonucleotides have opposite charges.
3. Hybridisation-based methods rely on specific base pairing between complementary sequences on nanoparticles and oligonucleotides.

• Application of Nanoparticle-Oligonucleotide Conjugation

Nanoparticles have specific dimensions and have some unique properties compared to macroscopic particles, such as increased specific surface area, enhanced stability and unique chemical properties, which allow nanoparticle-oligonucleotide conjugation to have a wide range of expanded biomedical applications.

• Drug Delivery
• Promoting Gene Silencing
• Biosensors
• Biomedical Imaging Agents

Introduction of Nanoparticle-Oligonucleotide Conjugation Services

• What Are Our Nanoparticle-Oligonucleotide Conjugation Services?

1. Design and synthesis of suitable oligonucleotide sequences to meet customer requirements.

2. Selection and preparation of suitable nanoparticles to meet customer needs. The following nanoparticles are commonly used for conjugating to oligonucleotides.

• Gold Nanoparticles
• Magnetic Nanoparticles
• Quantum Dots
• Silicon Dioxide Nanoparticles
• Lipid Nanoparticles
• Carbon-based Nanoparticles

3. Binding of chemically modified oligonucleotides to nanoparticles.

4. Purification and characterisation of nanoparticle-oligonucleotide conjugation.

5. Delivery of high quality nanoparticle-oligonucleotide conjugation and detailed analytical reports.

Figure 2. Service flow of nanoparticle-oligonucleotide conjugation.

• Why Choose Our Nanoparticle-Oligonucleotide Conjugation Services?

1.Top Quality

BOC Sciences' nanoparticle-oligonucleotide conjugation service uses top quality nanoparticles and oligonucleotides to ensure the high quality of the resulting product.

2.High Efficiency

BOC Sciences has expertise and equipment to ensure efficient reactions and high yields of products.

3.Flexibility

BOC Sciences' nanoparticle-oligonucleotide conjugation services can be customised to meet a wide range of research needs.

4.Competitive Pricing

BOC Sciences offers competitive pricing on the premise of ensuring high quality of nanoparticle-oligonucleotide conjugation.

5. Perfect One-Stop Solution

BOC Sciences provides professional technical support, consulting services and after-sales services throughout the entire process, assisting customers with a wide range of issues and problems.

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Nanoparticle-Oligonucleotide Conjugation

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