Virus-Like Particle-Oligonucleotide Conjugation

BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with virus-like particles(VLPs). We have the capability and confidence to meet your needs for novel conjugates.

What is VLP-Oligonucleotide Conjugation?

Virus-Like Particles (VLPs) are self-assembling structures that mimic viral shells but do not contain the genetic material required for replication, usually derived from viral proteins, and can be used as safe and effective vaccine platforms or drug delivery systems. The combination of oligonucleotides with VLPs can be used for a variety of purposes, including targeted drug delivery, immunotherapy or diagnostics. In addition, oligonucleotides can be designed to carry specific sequences that interact with cellular receptors, specific tissues or disease markers, allowing for precise targeting.

Figure 1. Virus-like particles (VLP) as scaffolds and vectors for vaccine development. (Milad, R; et al, 2023)

• Preparation of VLP-Oligonucleotide Conjugation

The splicing process usually involves oligonucleotides and VLPs that have been modified in advance to introduce functional groups that can form covalent or non-covalent bonds. Oligonucleotides can be chemically modified using a variety of reactive groups, while the VLP surface can be designed to display complementary reactive groups or specific binding motifs. When mixed together, the oligonucleotides and the reactive groups on the VLP can form a stable linkage leading to the conjugation of the oligonucleotide to the VLP.

• Advantages of VLP-Oligonucleotide Conjugation in Biomedical Applications

• Excellent Targeted Delivery Performance
• Enhanced Stability
• Improved Immunogenicity
• Structural Mimicry Promotes Cellular Uptake
• Versatility Enabling a Wide Range of Design Strategies

Introduction of VLP-Oligonucleotide Conjugation Services

• What Are Our VLP-Oligonucleotide Conjugation Services?

1. Oligonucleotide Synthesis & Modification: BOC Sciences' specialist synthesis team can synthesise oligonucleotides to meet the needs of our clients.

2. VLP Options: There are the following common options available at BOC Sciences.

• HPV VLPs
• HBV VLPs
• Bacteriophage VLPs

3. Optimisation of Coupling Methods: BOC Sciences takes the most optimised coupling methods to prepare VLP-oligonucleotide conjugations.

4. Purity, Stability, Storage Performance Testing: BOC Sciences offers detailed purification and representation experiments to ensure the high quality of VLP-oligonucleotide conjugation.

Figure 2. Service flow of VLP-oligonucleotide conjugation.

• Why Choose Our VLP-Oligonucleotide Conjugation Services?

• BOC Sciences has the most competitive prices in the market for oligonucleotide synthesis products, but at the same time ensures rigorous quality testing and quality control.
• BOC Sciences is committed to providing high purity and quality products to ensure the accuracy and reliability of our customers' experimental results.
• BOC Sciences can provide VLP-oligonucleotide conjugations in high volume production to ensure on-time or even early delivery.
• BOC Sciences' VLP-oligonucleotide conjugation service can be customised to meet the specific needs of our customers with different experimental requirements.

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Virus-Like Particle-Oligonucleotide Conjugation

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