Custom Small Activating RNA Synthesis

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BOC Sciences provides high-quality, cost-effective custom RNA Oligos synthesis services with flexible synthesis specifications to meet the diverse needs of a wide range of researchers.

What is Small Activating RNA?

RNA activation is a type of RNA regulation that activates the expression of target genes at the transcriptional level. Small molecule RNAs that can activate gene transcription are known as small activating RNAs (saRNAs). saRNAs are short, double-stranded oligonucleotides, usually consisting of 19 to 30 nucleotides, with a specific sequence and structure. Compared with traditional gene therapy, saRNAs have unparalleled advantages in tumor therapy, and have broad application prospects in both tumor pathogenesis and tumor research.

How do Small Activating RNAs Work?

Similar to other RNAs (antisense oligonucleotide/ASO, RNAi, siRNA, etc.), saRNAs work by binding to target nucleic acids, but unlike other RNAs, saRNAs ultimately activate gene expression.

The mechanism of saRNA action is that the double-stranded saRNA enters the cell by endocytosis and is then loaded onto the AGO2 protein. After the carrier chain is degraded, AGO2 and the active chain complex are transported into the nucleus and bind to the promoter region. Subsequently, it attracts RNA polymerase by binding to RNA deconjugating enzyme and RNA polymerase linker protein (CTR9) to activate the transcription of the corresponding genes, and ultimately promotes the expression of the corresponding proteins.

Proposed model of small activating RNA mechanism.Fig 1. Proposed model of small activating RNA mechanism. (Kwok et al., 2019)

BOC Sciences' Custom saRNA Synthesis Services

BOC Sciences has developed a powerful bioinformatics platform to design saRNAs for target gene activation. These saRNA sequences recognize elements upstream of the mRNA transcription start site and downstream of the polyA site.

Advantages of BOC Sciences' saRNA Synthesis Services

Reference

  1. Kwok A, et al. Developing small activating RNA as a therapeutic: current challenges and promises[J]. Therapeutic delivery, 2019, 10(3): 151-164.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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