RNA Phosphoramidites

RNA Phosphoramidites

With many years of experience in engineered nucleic acid production, BOC RNA has accumulated a wealth of phosphoramidite technology expertise in protection chemistry, modification, production scale-up, and innovative purification strategies. We provide high-quality phosphoramidites for RNA oligonucleotide synthesis. All standard (and customized) phosphoramidite production is strictly controlled by process and quality.
Our phosphoramidite products include RNA phosphoramidites, 2’-OMe-phosphoramidites, 2’-F-phosphoramidites, 2’-MOE-phosphoramidites, 3’-TBDMS-RNA phosphoramidites, 5-modified phosphoramidites, etc.

RNA phosphoramidites
  • Ideal for synthesis therapeutic (and research) high-fidelity oligonucleotides, such as gene synthesis, gene editing, CRISPR-cas9 gRNA, antisense (ASO), and siRNA.
  • Used to help increase the stability of oligonucleotides and increase resistance to nuclease activity in the body.
  • Supporting a variety of nucleic acid-based applications such as antisense, siRNA, gene design and genome editing, including CRISPR-cas9 gRNA.
3’-TBDMS-RNA phosphoramidites
5-modified phosphoramidites

Quality control

  • The entire process is monitored from material procurement to final quality control and product release, providing repeatability and security between batches
  • Assess purity of each RNA phosphoramidite batch by HPLC and 31 P NMR
  • The tightly controlled manufacturing process ensures minimal levels of impurities

Custom services

Custom manufacturing services available to help develop or expand phosphoramidite compounds

Products for RNA synthesis

* Only for research. Not suitable for any diagnostic or therapeutic use.
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