With many years of experience in engineered nucleic acid production, BOC RNA has accumulated a wealth of phosphoramidite technology expertise in protection chemistry, modification, production scale-up, and innovative purification strategies. We provide high-quality phosphoramidites for RNA oligonucleotide synthesis. All standard (and customized) phosphoramidite production is strictly controlled by process and quality.
Our phosphoramidite products include RNA phosphoramidites, 2’-OMe-phosphoramidites, 2’-F-phosphoramidites, 2’-MOE-phosphoramidites, 3’-TBDMS-RNA phosphoramidites, 5-modified phosphoramidites, etc.
| Phosphoramidites | Features |
| RNA phosphoramidites | - Ideal for synthesis therapeutic (and research) high-fidelity oligonucleotides, such as gene synthesis, gene editing, CRISPR-cas9 gRNA, antisense (ASO), and siRNA.
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| 2’-OMe-phosphoramidites | - Used to help increase the stability of oligonucleotides and increase resistance to nuclease activity in the body.
- Supporting a variety of nucleic acid-based applications such as antisense, siRNA, gene design and genome editing, including CRISPR-cas9 gRNA.
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| 2’-F-phosphoramidites |
| 2’-MOE-phosphoramidites |
| 3’-TBDMS-RNA phosphoramidites |
| 5-modified phosphoramidites |
Quality control
- The entire process is monitored from material procurement to final quality control and product release, providing repeatability and security between batches
- Assess purity of each RNA phosphoramidite batch by HPLC and 31 P NMR
- The tightly controlled manufacturing process ensures minimal levels of impurities
Custom services
Custom manufacturing services available to help develop or expand phosphoramidite compounds
Products for RNA synthesis
