With many years of experience in engineered nucleic acid production, BOC RNA has accumulated a wealth of phosphoramidite technology expertise in protection chemistry, modification, production scale-up, and innovative purification strategies. We provide high-quality phosphoramidites for RNA oligonucleotide synthesis. All standard (and customized) phosphoramidite production is strictly controlled by process and quality.
Our phosphoramidite products include RNA phosphoramidites, 2’-OMe-phosphoramidites, 2’-F-phosphoramidites, 2’-MOE-phosphoramidites, 3’-TBDMS-RNA phosphoramidites, 5-modified phosphoramidites, etc.
Phosphoramidites
Features
RNA phosphoramidites
Ideal for synthesis therapeutic (and research) high-fidelity oligonucleotides, such as gene synthesis, gene editing, CRISPR-cas9 gRNA, antisense (ASO), and siRNA.
2’-OMe-phosphoramidites
Used to help increase the stability of oligonucleotides and increase resistance to nuclease activity in the body.
Supporting a variety of nucleic acid-based applications such as antisense, siRNA, gene design and genome editing, including CRISPR-cas9 gRNA.
2’-F-phosphoramidites
2’-MOE-phosphoramidites
3’-TBDMS-RNA phosphoramidites
5-modified phosphoramidites
Quality control
The entire process is monitored from material procurement to final quality control and product release, providing repeatability and security between batches
Assess purity of each RNA phosphoramidite batch by HPLC and 31 P NMR
The tightly controlled manufacturing process ensures minimal levels of impurities
Custom services
Custom manufacturing services available to help develop or expand phosphoramidite compounds
* Only for research. Not suitable for any diagnostic or therapeutic use.
