Name: N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyladenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
Brand: BOC Sciences
Price: 199 USD
Availability: MadeToOrder

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N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyladenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyladenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyladenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a benzoyl group protecting the adenine base, a 5'-dimethoxytrityl (DMT) group for 5'-hydroxyl protection, a 2'-O-methyl group to enhance stability, and a cyanoethyl (CE) group on the 3'-phosphoramidite for protection during synthesis. These modifications facilitate the incorporation of modified adenosine into oligonucleotides, improving their stability and performance in various applications such as genetic research and therapeutic development.

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Ordering Information

Catalog Number	Size	Price	Stock	Quantity
BRP-02194	5 g	$199	In stock

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Catalog

BRP-02194

Synonyms

N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine 3'-CE phosphoramidite; Dmt-2'-O-me-ra(bz) amidite; 2'-O-Methyl-rA(N-Bz)phosphoramidite; DMT-2'O-Methyl-rA(bz) Phosphoramidite; 5'-O-DMT-2'-O-Me-A(bz) phosphoramidite; 2'-OMe-Bz-A-CE-Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-Adenosine-3'-CE-Phosphoramidite

CAS

110782-31-5

IUPAC Name

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]purin-6-yl]benzamide

Molecular Weight

887.96

Molecular Formula

C48H54N7O8P

Canonical SMILES

CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=NC3=C2N=CN=C3NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

InChI

InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1

InChIKey

AZCGOTUYEPXHMJ-PSVHYZMASA-N

Melting Point

93-95 °C

Purity

≥98% by HPLC

Solubility

Soluble in Acetonitrile (Sparingly), DMSO (Slightly), Methanol (Slightly)

Appearance

White to Off-white Solid

Storage

Store at -20 °C, under inert atmosphere