COVID-19 offers great scope for the development of mRNA vaccines, however, the key issue affecting the role of mRNA is delivery. Delivery vehicles protect the efficient transport of mRNA vaccines to the target site and their timely release. Here, BOC Sciences provides fully validated and optimised polymer complex mRNA delivery systems to assist customers in the development and production of mRNA vaccines for infectious disease and cancer control applications.
Polymer complexes are widely used in mRNA delivery for efficient gene transcription and protein expression. mRNA delivery is the delivery of exogenous mRNA into the cell to prompt the cell to produce the desired protein. Polymer complexes can achieve the advantages of mRNA stability, controlled release and targeted delivery by combining mRNA with a polymer to form a complex structure.
Figure 1. Polymers complexes loaded with mRNA.
Although clinical progress has not been as rapid as with LNP, polymers have similar advantages to lipids and are also effective in delivering mRNA. cationic polymers can form complexes of different sizes with mRNA. A variety of biodegradable polymeric materials are available for efficient delivery of mRNA. Similar to ionisable lipid molecules, pH-sensitive polymers have also been used to deliver mRNA, and these polymers are protonated at the acidic pH of the endosome, facilitating the release of RNA.
BOC Sciences' experts can provide mRNA-polymer coupling services on request. Polymeric materials (including PEGs, polyamines, dendrimers and copolymers) are functional materials capable of delivering mRNA vaccines, protecting RNA from RNase-mediated degradation and facilitating intracellular delivery. In addition, we support the polymerisation of various types of materials and various modifications (binding of lipid chains, hyperbranched groups, biodegradable subunits, etc.). You can contact us directly with any ideas you may have and let BOC Sciences support you.
|Type of polymer complexes
|PLGA is a biodegradable polymer with good biocompatibility and delivery properties.
|PEI is a cationic polymer with high transfection efficiency. PEI can form complexes with mRNA and facilitate the interaction of the complex with the cell membrane through its cationic properties, resulting in efficient mRNA delivery.
|PLA offers biodegradability and delivery control properties.
|PEG-modified polymers can be used to improve the stability and biocompatibility of the complexes. These complexes can be used to improve circulation times through PEG chain lengthening and to reduce recognition and clearance by the immune system.
|Dendrimer is a polymer with a branching structure that allows Dendrimer to have multiple surface functional groups that can be used to interact with mRNA and facilitate the delivery of mRNA into the cell.
|Copolymers are formed from two or more different monomers through copolymerisation reactions, combining the properties of the different monomers to provide a variety of functions and benefits for enhanced mRNA delivery, such as PEI-PEG, PLA-PEG, PCL-PEG, etc.
|The complexes formed by binding nanocellulose to mRNA can be used for mRNA protection and delivery, while having good biodegradability.
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