Polymer Complexes

COVID-19 offers great scope for the development of mRNA vaccines, however, the key issue affecting the role of mRNA is delivery. Delivery vehicles protect the efficient transport of mRNA vaccines to the target site and their timely release. Here, BOC Sciences provides fully validated and optimised polymer complex mRNA delivery systems to assist customers in the development and production of mRNA vaccines for infectious disease and cancer control applications.

Introduction of Polymer Complexes

Polymer complexes are widely used in mRNA delivery for efficient gene transcription and protein expression. mRNA delivery is the delivery of exogenous mRNA into the cell to prompt the cell to produce the desired protein. Polymer complexes can achieve the advantages of mRNA stability, controlled release and targeted delivery by combining mRNA with a polymer to form a complex structure.

Figure 1. Polymers complexes loaded with mRNA.

• Polymeric complexes are used as carriers and controlled release systems for drugs. Drug molecules can interact with polymers either physically or chemically and are thus encapsulated or embedded in the polymer's structure. This encapsulation protects the drug molecule from external environmental damage and controls the rate and timing of drug release, enabling continuous drug delivery.
• Polymeric complexes can be adapted to achieve targeted drug delivery by adapting their chemical structure and functional groups. For example, specific ligands or antibodies can be introduced to the polymer, giving the complex the ability to bind selectively to the target molecule. In this way, the drug can be more precisely targeted to the target tissue or cell, improving therapeutic efficacy and reducing adverse effects on healthy tissue.
• Many polymers have good biocompatibility and biodegradability, making them ideal for use in drug delivery. These polymers can be metabolised or degraded to harmless metabolites in the body, reducing toxicity and side effects to the organism.
• Polymer complexes can further be used to build multifunctional drug delivery systems by introducing functional molecules or nanomaterials. These functional components can include targeting molecules, visualisation agents, photosensitisers or thermosensitisers to enable targeted drug treatment, visual monitoring or controlled drug release by external stimuli.

Polymer Complexes in mRNA Vaccines

Although clinical progress has not been as rapid as with LNP, polymers have similar advantages to lipids and are also effective in delivering mRNA. cationic polymers can form complexes of different sizes with mRNA. A variety of biodegradable polymeric materials are available for efficient delivery of mRNA. Similar to ionisable lipid molecules, pH-sensitive polymers have also been used to deliver mRNA, and these polymers are protonated at the acidic pH of the endosome, facilitating the release of RNA.

BOC Sciences' Polymer Complexes Carrier-based mRNA Vaccine Development Support Service

BOC Sciences' experts can provide mRNA-polymer coupling services on request. Polymeric materials (including PEGs, polyamines, dendrimers and copolymers) are functional materials capable of delivering mRNA vaccines, protecting RNA from RNase-mediated degradation and facilitating intracellular delivery. In addition, we support the polymerisation of various types of materials and various modifications (binding of lipid chains, hyperbranched groups, biodegradable subunits, etc.). You can contact us directly with any ideas you may have and let BOC Sciences support you.

• Design and synthesis of mRNA by IVT
• Production and purification of mRNA
• Characterization of polymer complexes

• mRNA-polymer coupling services
• In vitro&in vivo validation
• Optional polymer complexes construction

Contact us to tell us more about your needs. The expertise of our scientists, engineers and support team are at your disposal!